DT-Web

DB00533 - Rofecoxib


Identification
Name Rofecoxib
Accession Number DB00533 (APRD00151)
Type small molecule
Description On September 30, 2004, Merck voluntarily withdrew rofecoxib from the market because of concerns about increased risk of heart attack and stroke associated with long-term, high-dosage use.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 314.356
Groups withdrawn
Monoisotopic Weight 314.061279626
Pharmacology
Indication For the treatment of osteoarthritis, rheumatoid arthritis, acute pain in adults, and primary dysmenorrhea, as well as acute treatment of migraine attacks with or without auras.
Mechanism of action The anti-inflammatory, analgesic, and antipyretic effects of NSAIDs appear to result from the inhibition of prostaglandin synthesis. Although the exact mechanism of action has not been determined, these effects appear to be mediated through the inhibition of the COX-2 isoenzyme at the sites of inflammation with subsequent reduction in the synthesis of certain prostaglandins from their arachidonic acid precursors. Rofecoxib selectively inhibits the cyclooxygenase-2 (COX-2) enzyme, which is important for the mediation of inflammation and pain. Unlike non-selective NSAIDs, rofecoxib does not inhibit platelet aggregation. It also has little to no affinity for COX-1.
Absorption The mean oral bioavailability of rofecoxib at therapeutically recommended doses of 12.5, 25, and 50 mg is approximately 93%.
Protein binding 87%
Biotransformation Hepatic. Metabolism of rofecoxib is primarily mediated through reduction by cytosolic enzymes. The principal metabolic products are the cis-dihydro and trans-dihydro derivatives of rofecoxib, which account for nearly 56% of recovered radioactivity in the urine. An additional 8.8% of the dose was recovered as the glucuronide of the hydroxy derivative, a product of oxidative metabolism. The biotransformation of rofecoxib and this metabolite is reversible in humans to a limited extent (< 5%). These metabolites are inactive as COX-1 or COX-2 inhibitors. Cytochrome P450 plays a minor role in metabolism of rofecoxib.
Route of elimination Not Available
Toxicity No overdoses of rofecoxib were reported during clinical trials. Administration of single doses of rofecoxib 1000 mg to 6 healthy volunteers and multiple doses of 250 mg/day for 14 days to 75 healthy volunteers did not result in serious toxicity.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Aminophylline Rofecoxib increases the effect and toxicity of theophylline
Lithium The COX-2 inhibitor increases serum levels of lithium
Methotrexate Rofecoxib increases the levels of methotrexate
Oxtriphylline Rofecoxib increases the effect and toxicity of theophylline
Theophylline Rofecoxib increases the effect and toxicity of theophylline
Food Interactions Not Available

Targets


Prostaglandin G/H synthase 2
Name Prostaglandin G/H synthase 2
Gene Name PTGS2
Pharmacological action yes
Actions inhibitor
References
  • Ehrich EW, Schnitzer TJ, McIlwain H, Levy R, Wolfe F, Weisman M, Zeng Q, Morrison B, Bolognese J, Seidenberg B, Gertz BJ: Effect of specific COX-2 inhibition in osteoarthritis of the knee: a 6 week double blind, placebo controlled pilot study of rofecoxib. Rofecoxib Osteoarthritis Pilot Study Group. J Rheumatol. 1999 Nov;26(11):2438-47. - Pubmed
  • Malmstrom K, Daniels S, Kotey P, Seidenberg BC, Desjardins PJ: Comparison of rofecoxib and celecoxib, two cyclooxygenase-2 inhibitors, in postoperative dental pain: a randomized, placebo- and active-comparator-controlled clinical trial. Clin Ther. 1999 Oct;21(10):1653-63. - Pubmed
  • Langman MJ, Jensen DM, Watson DJ, Harper SE, Zhao PL, Quan H, Bolognese JA, Simon TJ: Adverse upper gastrointestinal effects of rofecoxib compared with NSAIDs. JAMA. 1999 Nov 24;282(20):1929-33. - Pubmed
  • Pascucci RA: COX-2-specific inhibition: implications for clinical practice. J Am Osteopath Assoc. 1999 Nov;99(11 Suppl):S18-22. - Pubmed
  • Hawkey C, Laine L, Simon T, Beaulieu A, Maldonado-Cocco J, Acevedo E, Shahane A, Quan H, Bolognese J, Mortensen E: Comparison of the effect of rofecoxib (a cyclooxygenase 2 inhibitor), ibuprofen, and placebo on the gastroduodenal mucosa of patients with osteoarthritis: a randomized, double-blind, placebo-controlled trial. The Rofecoxib Osteoarthritis Endoscopy Multinational Study Group. Arthritis Rheum. 2000 Feb;43(2):370-7. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Ashok V, Dash C, Rohan TE, Sprafka JM, Terry PD: Selective cyclooxygenase-2 (COX-2) inhibitors and breast cancer risk. Breast. 2010 Aug 17. - Pubmed
  • Baron JA, Sandler RS, Bresalier RS, Lanas A, Morton DG, Riddell R, Iverson ER, Demets DL: Cardiovascular events associated with rofecoxib: final analysis of the APPROVe trial. Lancet. 2008 Nov 15;372(9651):1756-64. Epub 2008 Oct 14. - Pubmed
  • Chakraborti AK, Garg SK, Kumar R, Motiwala HF, Jadhavar PS: Progress in COX-2 inhibitors: a journey so far. Curr Med Chem. 2010;17(15):1563-93. - Pubmed
  • Matheson AJ, Figgitt DP: Rofecoxib: a review of its use in the management of osteoarthritis, acute pain and rheumatoid arthritis. Drugs. 2001;61(6):833-65. - Pubmed
DTHybrid score 0.6207
Elastin
Name Elastin
Gene Name ELN
Pharmacological action unknown
Actions other/unknown
References
  • Oitate M, Hirota T, Koyama K, Inoue S, Kawai K, Ikeda T: Covalent binding of radioactivity from [14C]rofecoxib, but not [14C]celecoxib or [14C]CS-706, to the arterial elastin of rats. Drug Metab Dispos. 2006 Aug;34(8):1417-22. Epub 2006 May 5. - Pubmed
  • Oitate M, Hirota T, Takahashi M, Murai T, Miura S, Senoo A, Hosokawa T, Oonishi T, Ikeda T: Mechanism for covalent binding of rofecoxib to elastin of rat aorta. J Pharmacol Exp Ther. 2007 Mar;320(3):1195-203. Epub 2006 Dec 12. - Pubmed
  • Oitate M, Hirota T, Murai T, Miura S, Ikeda T: Covalent binding of rofecoxib, but not other cyclooxygenase-2 inhibitors, to allysine aldehyde in elastin of human aorta. Drug Metab Dispos. 2007 Oct;35(10):1846-52. Epub 2007 Jul 9. - Pubmed
DTHybrid score 0.2717

Enzymes


Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate,inhibitor
References
  • Wang B, Zhou SF: Synthetic and natural compounds that interact with human cytochrome P450 1A2 and implications in drug development. Curr Med Chem. 2009;16(31):4066-218. - Pubmed
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4183
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inducer
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5441
Prostaglandin G/H synthase 1
Name Prostaglandin G/H synthase 1
Gene Name PTGS1
Actions substrate
References
  • Zhou SF, Zhou ZW, Yang LP, Cai JP: Substrates, inducers, inhibitors and structure-activity relationships of human Cytochrome P450 2C9 and implications in drug development. Curr Med Chem. 2009;16(27):3480-675. Epub 2009 Sep 1. - Pubmed
DTHybrid score 0.6932
Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3754
Cytochrome P450 2C9
Name Cytochrome P450 2C9
Gene Name CYP2C9
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5266

Transporters


Multidrug resistance-associated protein 4
Name Multidrug resistance-associated protein 4
Gene Name ABCC4
Actions inhibitor
References
  • Reid G, Wielinga P, Zelcer N, van der Heijden I, Kuil A, de Haas M, Wijnholds J, Borst P: The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9244-9. Epub 2003 Jun 30. - Pubmed
DTHybrid score 0.2365

Predictions


Id Partner name Gene Name Score
6016 Cytochrome P450 2C19 CYP2C19 0.2503
4119 Cytochrome P450 2D6 CYP2D6 0.2235
1588 Multidrug resistance protein 1 ABCB1 0.1816
4118 Cytochrome P450 3A5 CYP3A5 0.1509
587 Serum albumin ALB 0.1344
6013 Cytochrome P450 2E1 CYP2E1 0.1314
6030 Cytochrome P450 2B6 CYP2B6 0.1303
1729 Solute carrier family 22 member 6 SLC22A6 0.1202
6107 Cytochrome P450 3A7 CYP3A7 0.106
6024 Cytochrome P450 1A1 CYP1A1 0.1009
5718 Cytochrome P450 2A6 CYP2A6 0.0817
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0759
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0743
6142 Solute carrier family 22 member 8 SLC22A8 0.0708
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0673
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0598
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0596
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0554
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0538
275 Arachidonate 5-lipoxygenase ALOX5 0.0534
6106 Cytochrome P450 2C18 CYP2C18 0.0533
862 Multidrug resistance-associated protein 1 ABCC1 0.0505
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0485
1024 Solute carrier family 22 member 11 SLC22A11 0.0441
6136 Multidrug resistance-associated protein 5 ABCC5 0.0439
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0428
6143 Solute carrier family 22 member 7 SLC22A7 0.0419
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0413
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0408
3811 Cytochrome P450 19A1 CYP19A1 0.0392
492 Histamine H1 receptor HRH1 0.0389
1757 Myeloperoxidase MPO 0.0383
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0334
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0328
1898 Cytochrome P450 1B1 CYP1B1 0.0321
6145 Solute carrier family 22 member 1 SLC22A1 0.0295
824 Sodium-dependent serotonin transporter SLC6A4 0.0295
136 Estrogen receptor ESR1 0.0291
502 5-hydroxytryptamine 2A receptor HTR2A 0.0287
776 Bile salt export pump ABCB11 0.0277
871 Glucocorticoid receptor NR3C1 0.0269
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0269
6144 Solute carrier family 22 member 2 SLC22A2 0.0265
831 D(2) dopamine receptor DRD2 0.026
36 Insulin receptor INSR 0.0258
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0256
3923 Cholinesterase BCHE 0.0254
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0251
556 Alpha-1A adrenergic receptor ADRA1A 0.0238
318 Alpha-2A adrenergic receptor ADRA2A 0.0237
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0236
373 Transthyretin TTR 0.0231
777 Tumor necrosis factor TNF 0.0216
6141 Sodium/bile acid cotransporter SLC10A1 0.0216
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0216
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0215
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0214
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0211
118 Organic cation/carnitine transporter 2 SLC22A5 0.0207
6220 Aryl hydrocarbon receptor AHR 0.0205
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0202
6148 Multidrug resistance-associated protein 7 ABCC10 0.0202
146 Androgen receptor AR 0.02
3312 Fatty acid-binding protein, brain FABP7 0.0199
3941 Amine oxidase [flavin-containing] A MAOA 0.0194
590 5-hydroxytryptamine 2C receptor HTR2C 0.0191
847 Mu-type opioid receptor OPRM1 0.019
51 Muscarinic acetylcholine receptor M3 CHRM3 0.019
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0189
70 Type-1 angiotensin II receptor AGTR1 0.0189
341 5-hydroxytryptamine 3 receptor HTR3A 0.0188
23 D(1A) dopamine receptor DRD1 0.0188
1159 Interleukin-6 IL6 0.0185
738 Monocarboxylate transporter 1 SLC16A1 0.0185
731 HIV-1 protease HIV-1 protease 0.0184
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0183
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0183
817 DNA topoisomerase 2-alpha TOP2A 0.0182
320 5-hydroxytryptamine 1A receptor HTR1A 0.0181
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.018
6137 Multidrug resistance-associated protein 6 ABCC6 0.0177
467 Delta-type opioid receptor OPRD1 0.0177
3947 Xanthine dehydrogenase/oxidase XDH 0.0175
6102 Arylamine N-acetyltransferase 2 NAT2 0.0173
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0173
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0173
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0173
24 Thymidylate synthase TMP1 0.0171
359 Thymidylate synthase TYMS 0.0171
2626 Thymidylate synthase thyA 0.0171
2729 Thymidylate synthase thyA 0.0171
5352 Thymidylate synthase THYA 0.0171
260 Cytochrome P450 51 ERG11 0.0169
761 Cytochrome P450 51 ERG11 0.0169
3163 Cytochrome P450 51 cyp51 0.0169
696 Kappa-type opioid receptor OPRK1 0.0168
885 5-hydroxytryptamine 1B receptor HTR1B 0.0167
6147 Solute carrier family 22 member 3 SLC22A3 0.0166
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0165
891 Dihydropteroate synthase folP 0.0164
5359 Dihydropteroate synthase folP 0.0164
7175 Dihydropteroate synthase sulI 0.0164
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0163
632 Alpha-1B adrenergic receptor ADRA1B 0.0163
6085 Fatty acid-binding protein, intestinal FABP2 0.0161
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0161
4604 Liver carboxylesterase 1 CES1 0.0158
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0155
713 Sodium-dependent dopamine transporter SLC6A3 0.0155
122 P2Y purinoceptor 12 P2RY12 0.0152
5626 Nucleoside diphosphate kinase B NME2 0.0152
274 Muscarinic acetylcholine receptor M5 CHRM5 0.015
766 Beta-2 adrenergic receptor ADRB2 0.0149
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0149
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0148
811 Translocator protein TSPO 0.0148
725 5-hydroxytryptamine 1D receptor HTR1D 0.0147
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0146
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0146
477 DNA topoisomerase 4 subunit A parC 0.0146
886 DNA topoisomerase 4 subunit A parC 0.0146
6226 DNA topoisomerase 4 subunit A parC 0.0146
468 Cytochrome P450 4A11 CYP4A11 0.0144
404 DNA gyrase subunit A gyrA 0.0144
6224 DNA gyrase subunit A gyrA 0.0144
185 Vasopressin V1a receptor AVPR1A 0.0142
504 Mast/stem cell growth factor receptor KIT 0.0142
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0141
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0141
322 Vasopressin V2 receptor AVPR2 0.014
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0139
614 Progesterone receptor PGR 0.0139
3939 Amine oxidase [flavin-containing] B MAOB 0.0139
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0139
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0137
6043 Putative G-protein coupled receptor 44 GPR44 0.0137
672 Prostaglandin F2-alpha receptor PTGFR 0.0135
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0134
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0133
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0133
6031 Cytochrome P450 3A43 CYP3A43 0.0133
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0133
703 NADPH azoreductase azr 0.0132
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0132
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.013
6033 High affinity interleukin-8 receptor A CXCR1 0.013
789 Alpha-1D adrenergic receptor ADRA1D 0.0129
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0129
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0129
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0128
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0126
465 Calmodulin CALM1 0.0125
629 Alpha-2B adrenergic receptor ADRA2B 0.0124
193 Beta-1 adrenergic receptor ADRB1 0.0123
850 Vasopressin V1b receptor AVPR1B 0.0122
407 Vascular endothelial growth factor receptor 2 KDR 0.0122
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0122
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0122
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0121
5294 Nucleoside diphosphate kinase A NME1 0.0121
232 Corticosteroid-binding globulin SERPINA6 0.012
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0119
228 Beta platelet-derived growth factor receptor PDGFRB 0.0118
26 Vascular endothelial growth factor receptor 3 FLT4 0.0118
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0118
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0118
6020 Aldehyde oxidase AOX1 0.0118
1507 Cytochrome c CYCS 0.0117
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0116
6182 Cytochrome P450 2J2 CYP2J2 0.0115
638 D(3) dopamine receptor DRD3 0.0115
853 Farnesyl pyrophosphate synthetase FDPS 0.0113
32 Vascular endothelial growth factor receptor 1 FLT1 0.0113
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0111
833 Organic cation/carnitine transporter 1 SLC22A4 0.0111
723 Cytosolic phospholipase A2 PLA2G4A 0.0111
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0109
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0109
130 Prostacyclin synthase PTGIS 0.0109
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0109
33 Cystine/glutamate transporter SLC7A11 0.0108
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0108
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0108
6012 Tryptophan 2,3-dioxygenase TDO2 0.0106
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0104
6149 Solute carrier family 22 member 10 SLC22A10 0.0103
737 Mineralocorticoid receptor NR3C2 0.0102
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0102
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0102
16 Adenosine A1 receptor ADORA1 0.0101
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0101
958 Insulin-like growth factor 1 receptor IGF1R 0.0101
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0101
378 Alpha-2C adrenergic receptor ADRA2C 0.01
6014 Cytochrome P450 2A13 CYP2A13 0.0099
1650 Heme carrier protein 1 SLC46A1 0.0098
1439 Lactotransferrin LTF 0.0098
2183 Fatty acid-binding protein, adipocyte FABP4 0.0098
1656 CYP2B protein CYP2B 0.0098
273 Apoptosis regulator Bcl-2 BCL2 0.0098
4116 Dihydropteroate synthetase Not Available 0.0097
427 Substance-P receptor TACR1 0.0097
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0097
365 Dihydrofolate reductase DHFR 0.0096
2381 Dihydrofolate reductase DFR1 0.0096
2833 Dihydrofolate reductase Not Available 0.0096
2931 Dihydrofolate reductase folA 0.0096
3544 Dihydrofolate reductase folA 0.0096
3682 Dihydrofolate reductase folA 0.0096
6642 Dihydrofolate reductase folA 0.0096
6756 Dihydrofolate reductase dfrA 0.0096
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0095
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0092
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0092
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0092
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0092
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0091
436 5-hydroxytryptamine 2B receptor HTR2B 0.009
571 Melatonin receptor type 1A MTNR1A 0.009
4132 Chloride channel protein ClC-Ka CLCNKA 0.009
362 Melatonin receptor type 1B MTNR1B 0.009
558 Solute carrier family 12 member 1 SLC12A1 0.0089
818 50S ribosomal protein L10 rplJ 0.0089
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0088
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0088
869 Estrogen receptor beta ESR2 0.0088
1178 Adenosine A2a receptor ADORA2A 0.0088
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0087
782 ADP/ATP translocase 2 SLC25A5 0.0086
688 ADP/ATP translocase 3 SLC25A6 0.0086
823 Fibroblast growth factor receptor 2 FGFR2 0.0086
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0086
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0085
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0085
432 D(4) dopamine receptor DRD4 0.0084
3917 Methylenetetrahydrofolate reductase MTHFR 0.0084
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0083
2981 Phospholipase A2, membrane associated PLA2G2A 0.0083
459 Retinoic acid receptor RXR-alpha RXRA 0.0082
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0082
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0082
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0082
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0082
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0082
952 Dipeptidyl peptidase 4 DPP4 0.0082
489 Monocarboxylate transporter 2 SLC16A7 0.0082
29 Tubulin beta-1 chain TUBB1 0.0081
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0081
3957 Adenosine deaminase ADA 0.0081
844 Epidermal growth factor receptor EGFR 0.0081
1141 Sialidase-1 NEU1 0.008
64 Neuraminidase NA 0.008
641 Neuraminidase NA 0.008
2676 Neuraminidase NA 0.008
3026 Neuraminidase NA 0.008
3519 Neuraminidase NA 0.008
6007 Neuraminidase NA 0.008
165 FL cytokine receptor FLT3 0.008
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0079
3810 Catechol O-methyltransferase COMT 0.0079
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0079
94 5-hydroxytryptamine 4 receptor HTR4 0.0079
380 Cytochrome P450 17A1 CYP17A1 0.0078
1405 Thiopurine S-methyltransferase TPMT 0.0078
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0077
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0077
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0077
1275 Estrogen sulfotransferase SULT1E1 0.0077
1629 Transcription factor AP-1 JUN 0.0076
4221 Vascular endothelial growth factor VEGF 0.0075
5816 Cadherin-5 CDH5 0.0075
1541 Metalloproteinase mmp20 0.0074
1050 Bile salt sulfotransferase SULT2A1 0.0074
716 5-hydroxytryptamine 7 receptor HTR7 0.0073
3823 Cytokine receptor common gamma chain IL2RG 0.0073
756 Sex hormone-binding globulin SHBG 0.0072
342 P protein [Includes: DNA-directed DNA polymerase P 0.0072
612 P protein [Includes: DNA-directed DNA polymerase P 0.0072
295 Carbonic anhydrase 1 CA1 0.0071
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0071
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0071
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0071
4122 Histone deacetylase 2 HDAC2 0.0069
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0069
828 Phenylalanine-4-hydroxylase PAH 0.0069
3109 Phenylalanine-4-hydroxylase phhA 0.0069
49 Endothelin B receptor EDNRB 0.0069
3808 Dihydropteroate synthase 2 folP2 0.0069
3601 Dihydropteroate synthase 1 folP1 0.0069
3807 Dihydropteroate synthase 1 folP1 0.0069
68 Cannabinoid receptor 1 CNR1 0.0069
904 Glutathione S-transferase P GSTP1 0.0068
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0068
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0068
2021 Thrombomodulin THBD 0.0068
6500 Phospholipase A2 PLA2G1B 0.0068
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0067
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0067
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0067
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0067
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0067
592 Carbonic anhydrase 4 CA4 0.0067
6167 Organic solute transporter subunit beta OSTB 0.0066
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0066
6166 Organic solute transporter subunit alpha OSTA 0.0066
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0066
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0066
88 Retinoic acid receptor RXR-beta RXRB 0.0066
908 Glutathione S-transferase theta-1 GSTT1 0.0066
6103 Arylamine N-acetyltransferase 1 NAT1 0.0065
578 Endothelin-1 receptor EDNRA 0.0065
1714 Mitogen-activated protein kinase 3 MAPK3 0.0065
1010 Cytochrome P450 51A1 CYP51A1 0.0065
661 ADP/ATP translocase 1 SLC25A4 0.0064
1192 Sulfotransferase 1A1 SULT1A1 0.0064
921 Glutamate receptor 2 GRIA2 0.0064
724 Interleukin-2 receptor alpha chain IL2RA 0.0063
717 Interleukin-2 receptor subunit beta IL2RB 0.0063
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
133 Dihydropterate synthase sulI 0.0063
5482 Sialidase-2 NEU2 0.0062
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0062
3685 Catabolite gene activator crp 0.0061
511 5-hydroxytryptamine 1F receptor HTR1F 0.0061
4655 Adenylate cyclase cyaC 0.0061
4759 Adenylate cyclase cyaB2 0.0061
6146 High affinity copper uptake protein 1 SLC31A1 0.0061
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0061
293 Gamma-glutamyl hydrolase GGH 0.0061
474 Acetylcholinesterase ACHE 0.0061
634 Squalene monooxygenase SQLE 0.006
7196 Squalene monooxygenase ERG1 0.006
134 Tryptophan 5-hydroxylase 1 TPH1 0.006
4120 NADPH--cytochrome P450 reductase POR 0.006
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0059
4148 Serine/threonine-protein kinase mTOR MTOR 0.0059
5880 Thrombopoietin receptor MPL 0.0058
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0058
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0057
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0057
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0057
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0057
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0057
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0057
759 Free fatty acid receptor 1 FFAR1 0.0056
1818 Long-chain-fatty-acid--CoA ligase 3 ACSL3 0.0056
7 Nitric oxide synthase, inducible NOS2 0.0056
284 DNA-directed RNA polymerase beta chain rpoB 0.0056
5773 DNA-directed RNA polymerase beta chain rpoB 0.0056
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0056
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0056
814 Ryanodine receptor 1 RYR1 0.0056
4226 Uridine phosphorylase 2 UPP2 0.0056
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0055
163 D(1B) dopamine receptor DRD5 0.0055
2236 Casein kinase II subunit alpha CSNK2A1 0.0055
676 Tyrosine 3-monooxygenase TH 0.0054
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0054
124 Histamine H2 receptor HRH2 0.0053
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0053
3639 Thymidine phosphorylase deoA 0.0053
3936 Thymidine phosphorylase TYMP 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
2853 14 kDa fatty acid-binding protein Not Available 0.0053
4217 Telomerase reverse transcriptase TERT 0.0052
4760 Mll3241 protein mll3241 0.0052
565 Extracellular calcium-sensing receptor CASR 0.0052
712 Tubulin alpha chain TUB1 0.0052
161 Tubulin beta chain TUBB 0.0052
312 Tubulin beta chain TUB2 0.0052
518 Peroxidase/catalase T katG 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0051
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0051
4203 Histamine N-methyltransferase HNMT 0.0051
183 Vascular endothelial growth factor A VEGFA 0.0051
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0051
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.005
4225 Uridine phosphorylase 1 UPP1 0.005
714 Glutathione reductase, mitochondrial GSR 0.005
613 Atrial natriuretic peptide receptor A NPR1 0.005
357 Carbonic anhydrase 2 CA2 0.005
718 Folate receptor gamma FOLR3 0.005
299 Folate receptor beta FOLR2 0.005
804 Mitochondrial folate transporter/carrier SLC25A32 0.005
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0049
291 Nitric-oxide synthase, endothelial NOS3 0.0049
1053 BC269730_2 FADS1 0.0049
1395 Sodium/calcium exchanger 1 SLC8A1 0.0049
780 Retinoic acid receptor RXR-gamma RXRG 0.0049
856 Vitamin D3 receptor VDR 0.0049
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0048
4192 DNA topoisomerase 2-beta TOP2B 0.0048
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0048
413 Amidophosphoribosyltransferase PPAT 0.0048
2515 Amidophosphoribosyltransferase purF 0.0048
3714 Amidophosphoribosyltransferase purF 0.0048
482 Glycine receptor subunit alpha-1 GLRA1 0.0048
528 5-hydroxytryptamine 1E receptor HTR1E 0.0047
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0047
1792 Tissue-type plasminogen activator PLAT 0.0047
1198 Serum paraoxonase/arylesterase 1 PON1 0.0047
6223 Penicillin-binding protein 1C pbpC 0.0047
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0046
173 Toll-like receptor 7 TLR7 0.0046
4237 50S ribosomal protein L22 rplV 0.0046
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0045
1618 High affinity nerve growth factor receptor NTRK1 0.0045
992 Protein tyrosine kinase 2 beta PTK2B 0.0045
527 Prostacyclin receptor PTGIR 0.0045
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0045
6044 Serum paraoxonase/lactonase 3 PON3 0.0045
6042 Prostaglandin reductase 2 PTGR2 0.0045
208 DNA-directed RNA polymerase beta' chain rpoC 0.0044
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0044
4103 Proteasome subunit beta type 2 PSMB2 0.0044
4102 Proteasome subunit beta type 5 PSMB5 0.0044
4101 Proteasome subunit beta type 1 PSMB1 0.0044
6171 Solute carrier family 28 member 3 SLC28A3 0.0044
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0043
3809 Estrogen-related receptor gamma ESRRG 0.0043
1313 Lactoylglutathione lyase GLO1 0.0043
822 Aldose reductase AKR1B1 0.0043
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0043
1256 5-hydroxytryptamine 6 receptor HTR6 0.0041
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0041
106 Cannabinoid receptor 2 CNR2 0.0041
162 Retinoic acid receptor gamma-1 RARG 0.0041
3932 Glutathione S-transferase A2 GSTA2 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.004
2320 Thymidine kinase, cytosolic TK1 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.004
4773 Deoxycytidine kinase DCK 0.004
54 Prothrombin F2 0.004
6138 Multidrug resistance protein 3 ABCB4 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
6126 Carbonic anhydrase 7 CA7 0.0038
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0038
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0038
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0037
1789 Lymphotoxin-alpha LTA 0.0037
239 Coagulation factor X F10 0.0037
1269 Tumor necrosis factor receptor superfamily member 1B TNFRSF1B 0.0037
705 Glutamate receptor 1 GRIA1 0.0037
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0036
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0036
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0036
6218 Pannexin-1 PANX1 0.0035
2449 Tubulin alpha-3 chain TUBA1A 0.0035
117 Sterol O-acyltransferase 1 SOAT1 0.0035
2539 Tubulin alpha-1 chain TUBA4A 0.0035
939 50S ribosomal protein L3 rplC 0.0035
645 Penicillin-binding protein 1A mrcA 0.0035
5805 Penicillin-binding protein 1A ponA 0.0035
6185 Penicillin-binding protein 1A mrcA 0.0035
6799 Penicillin-binding protein 1A pbpA 0.0035
4311 tRNA TRDMT1 0.0034
4325 tRNA trmD 0.0034
4328 tRNA trmD 0.0034
1483 Membrane copper amine oxidase AOC3 0.0034
2499 Tubulin beta-2C chain TUBB2C 0.0034
153 Dopamine beta-hydroxylase DBH 0.0034
5300 Antigen peptide transporter 1 TAP1 0.0034
1374 Natriuretic peptides B NPPB 0.0034
1827 Gap junction alpha-1 protein GJA1 0.0034
1908 Vascular cell adhesion protein 1 VCAM1 0.0034
1517 Beta-3 adrenergic receptor ADRB3 0.0034
581 Cytochrome P450 2R1 CYP2R1 0.0034
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0033
3856 Fibroblast growth factor receptor 3 FGFR3 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
896 Glutathione S-transferase Mu 1 GSTM1 0.0033
229 Retinoic acid receptor beta RARB 0.0033
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0033
3587 Gastrotropin FABP6 0.0033
730 Retinoic acid receptor alpha RARA 0.0032
4784 Beta-mannosidase manB 0.0032
6695 Beta-mannosidase BT_0458 0.0032
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0032
6174 50S ribosomal protein L32 rpmF 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
1196 Complement decay-accelerating factor CD55 0.0031
3086 Plasmepsin-2 Not Available 0.0031
1227 Cytochrome b MT-CYB 0.0031
6386 Cytochrome b petB 0.0031
6937 Cytochrome b MT-CYB 0.0031
674 Dihydroorotate dehydrogenase homolog, mitochondrial PFF0160c 0.0031
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
115 Penicillin-binding protein 2 mrdA 0.003
6069 Penicillin-binding protein 2 mrdA 0.003
6118 Penicillin-binding protein 2 penA 0.003
6187 Penicillin-binding protein 2 pbpA 0.003
6686 Penicillin-binding protein 2 pbp2 0.003
6939 Penicillin-binding protein 2 mrdA 0.003
7163 Penicillin-binding protein 2 pbpA 0.003
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.003
4228 Keratin, type II cytoskeletal 7 KRT7 0.003
159 Penicillin-binding protein 2B penA 0.0029
6121 Penicillin-binding protein 2B penA 0.0029
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0029
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0029
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0029
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0029
2207 Rhodopsin RHO 0.0029
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0029
1039 Histone deacetylase 9 HDAC9 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
976 Platelet glycoprotein IX GP9 0.0028
543 Penicillin-binding protein 1B mrcB 0.0028
6186 Penicillin-binding protein 1B ponB 0.0028
6822 Penicillin-binding protein 1b pbp1b 0.0028
6844 Penicillin-binding protein 1b pbp1b 0.0028
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0028
1 Peptidoglycan synthetase ftsI ftsI 0.0028
4155 Peptidoglycan synthetase ftsI ftsI 0.0028
1200 AMBP protein AMBP 0.0028
3866 Serum amyloid A protein SAA1 0.0028
1932 Apolipoprotein E APOE 0.0028
1852 Microtubule-associated protein 2 MAP2 0.0028
6131 Carbonic anhydrase 14 CA14 0.0027
2808 Chloramphenicol acetyltransferase 3 cat3 0.0027
1144 Hepatocyte growth factor receptor MET 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
84 Nuclear receptor 0B1 NR0B1 0.0027
5787 Angiopoietin-1 receptor TEK 0.0027
2159 Quinone oxidoreductase CRYZ 0.0027
563 Thyroid peroxidase TPO 0.0027
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0027
702 UMP-CMP kinase CMPK1 0.0027
469 Annexin A1 ANXA1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0027
790 DNA polymerase subunit alpha B POLA2 0.0026
663 Solute carrier family 12 member 4 SLC12A4 0.0026
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0026
53 Solute carrier family 12 member 5 SLC12A5 0.0026
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0026
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0025
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0025
1864 RET proto-oncogene RET 0.0025
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0025
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0025
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0025
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0025
4787 Envelope glycoprotein gp160 env 0.0025
4820 Envelope glycoprotein gp160 env 0.0025
5727 Envelope glycoprotein gp160 env 0.0025
164 Histamine H4 receptor HRH4 0.0025
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
2417 Chloramphenicol acetyltransferase cat 0.0025
3278 Chloramphenicol acetyltransferase cat 0.0025
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
2810 Dr hemagglutinin structural subunit draA 0.0025
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0025
537 ATP synthase delta chain, mitochondrial ATP5D 0.0025
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0024
310 Solute carrier family 12 member 2 SLC12A2 0.0024
3814 Complement C1r subcomponent C1R 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0024
2297 Genome polyprotein Not Available 0.0024
2322 Genome polyprotein Not Available 0.0024
2694 Genome polyprotein Not Available 0.0024
2719 Genome polyprotein Not Available 0.0024
2860 Genome polyprotein Not Available 0.0024
2928 Genome polyprotein Not Available 0.0024
3160 Genome polyprotein Not Available 0.0024
3260 Genome polyprotein Not Available 0.0024
4783 Genome polyprotein Not Available 0.0024
5726 Genome polyprotein Not Available 0.0024
5779 Genome polyprotein Not Available 0.0024
5867 Genome polyprotein Not Available 0.0024
6253 Genome polyprotein Not Available 0.0024
6301 Genome polyprotein Not Available 0.0024
6380 Genome polyprotein Not Available 0.0024
6381 Genome polyprotein Not Available 0.0024
6437 Genome polyprotein Not Available 0.0024
6520 Genome polyprotein Not Available 0.0024
6521 Genome polyprotein Not Available 0.0024
6652 Genome polyprotein Not Available 0.0024
6734 Genome polyprotein Not Available 0.0024
6735 Genome polyprotein Not Available 0.0024
6736 Genome polyprotein Not Available 0.0024
6737 Genome polyprotein Not Available 0.0024
6738 Genome polyprotein Not Available 0.0024
6739 Genome polyprotein Not Available 0.0024
6744 Genome polyprotein Not Available 0.0024
6748 Genome polyprotein Not Available 0.0024
6894 Genome polyprotein Not Available 0.0024
6898 Genome polyprotein Not Available 0.0024
2112 Toll-like receptor 9 TLR9 0.0024
6070 Nischarin NISCH 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
268 Adenosine A2b receptor ADORA2B 0.0024
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0023
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0023
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0023
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0023
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0023
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0023
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0023
517 Alcohol dehydrogenase 1C ADH1C 0.0023
6432 Transporter snf 0.0022
2782 Complement C1s subcomponent C1S 0.0022
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0022
1992 Vitamin D-binding protein GC 0.0022
3480 Mannan endo-1,4-beta-mannosidase manA 0.0022
319 Opioid receptor, sigma 1 OPRS1 0.0022
6163 Copper-transporting ATPase 2 ATP7B 0.0022
6165 Copper-transporting ATPase 1 ATP7A 0.0022
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0022
936 Ephrin type-A receptor 2 EPHA2 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
2232 Interleukin-5 IL5 0.0022
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0021
298 Renin REN 0.0021
1593 Mucin-2 MUC2 0.0021
6506 Stathmin-4 STMN4 0.0021
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0021
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
3437 Eosinophil lysophospholipase CLC 0.0021
2091 Endoplasmin HSP90B1 0.0021
3937 Fatty-acid amide hydrolase FAAH 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
3817 Complement C1q subcomponent subunit C C1QC 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
3815 Complement C1q subcomponent subunit A C1QA 0.0021
3816 Complement C1q subcomponent subunit B C1QB 0.0021
1630 Integrin beta-2 ITGB2 0.0021
4041 Microsomal glutathione S-transferase 2 MGST2 0.0021
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0021
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0021
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0021
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0021
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0021
594 Thyroxine-binding globulin SERPINA7 0.002
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.002
3611 Cytidine deaminase cdd 0.002
3707 Cytidine deaminase cdd 0.002
4211 Cytidine deaminase CDA 0.002
4152 Superoxide dismutase [Cu-Zn] SOD1 0.002
5818 Folate receptor alpha FOLR1 0.002
1820 Beta-nerve growth factor NGF 0.002
6164 POU domain, class 5, transcription factor 1 POU5F1 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.002
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.002
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.002
1243 Cathepsin D CTSD 0.0019
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0019
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
5923 Microtubule-associated protein tau MAPT 0.0019
5924 Microtubule-associated protein 4 MAP4 0.0019
1291 cAMP response element-binding protein CREB1 0.0019
233 Potassium channel subfamily K member 2 KCNK2 0.0019
5934 Cytochrome P450 26A1 CYP26A1 0.0019
758 Thyroid hormone receptor alpha THRA 0.0019
751 Potassium channel subfamily K member 6 KCNK6 0.0018
174 Sigma 1-type opioid receptor SIGMAR1 0.0018
4210 Toll-like receptor 4 TLR4 0.0018
1262 Corticotropin-lipotropin POMC 0.0018
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0018
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
6048 Troponin C, skeletal muscle TNNC2 0.0018
683 Potassium transporter GK0582 0.0018
2391 Ferrochelatase hemH 0.0018
6502 Ferrochelatase DKFZp686P18130 0.0018
1591 Ferrochelatase, mitochondrial FECH 0.0018
1123 Eosinophil cationic protein RNASE3 0.0018
199 Monocarboxylate transporter 8 SLC16A2 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
719 Retinoic acid receptor responder protein 1 RARRES1 0.0017
770 Retinoic acid-induced protein 3 GPRC5A 0.0017
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0017
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0017
172 Potassium channel subfamily K member 1 KCNK1 0.0017
6824 Tyrosine-protein kinase Lyn LYN 0.0017
251 Alcohol dehydrogenase 1A ADH1A 0.0017
346 Thyroid hormone receptor beta-1 THRB 0.0017
4031 Glutathione S-transferase A1 GSTA1 0.0016
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0016
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0016
4948 Cytochrome c-553 Not Available 0.0016
4923 Cytochrome c3 DvMF_2499 0.0016
4945 Cytochrome c3 Not Available 0.0016
4949 Cytochrome c3 DVU_3171 0.0016
4968 Cytochrome c3 cytc3 0.0016
4997 Cytochrome c3 SO_2727 0.0016
5219 Cytochrome c3 cyd 0.0016
3189 High-molecular-weight cytochrome c hmcA 0.0016
4902 Nine-heme cytochrome c Ddes_2038 0.0016
3830 Calreticulin CALR 0.0016
572 Integrin alpha-L ITGAL 0.0016
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0016
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0016
5798 Mitogen-activated protein kinase 11 MAPK11 0.0016
820 Glycine receptor subunit alpha-2 GLRA2 0.0016
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0016
3913 Glutamic acid decarboxylase GAD65 0.0016
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0016
3233 Bile acid receptor NR1H4 0.0015
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0015
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0015
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0015
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0015
6493 Cytochrome c oxidase subunit 6C COX6C 0.0015
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0015
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0015
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0015
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0015
6559 Cytochrome c oxidase subunit 2 ctaC 0.0015
6669 Cytochrome c oxidase subunit 2 ctaC 0.0015
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0015
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0015
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0015
6558 Cytochrome c oxidase subunit 1 ctaD 0.0015
569 Retinal dehydrogenase 2 ALDH1A2 0.0015
267 Plasminogen activator inhibitor 1 SERPINE1 0.0015
4785 Ig gamma-1 chain C region IGHG1 0.0015
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0015
6034 Hydroxyindole O-methyltransferase ASMT 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
6035 Nuclear receptor ROR-beta RORB 0.0015
6036 Eosinophil peroxidase EPX 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
444 Alcohol dehydrogenase 1B ADH1B 0.0015
760 Fibroblast growth factor 1 FGF1 0.0015
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0015
1341 Histamine H3 receptor HRH3 0.0014
611 Retinal dehydrogenase 1 ALDH1A1 0.0014
2540 Choloylglycine hydrolase cbh 0.0014
2599 Tyrosine-protein kinase HCK HCK 0.0014
6221 Steroid hormone receptor ERR1 ESRRA 0.0014
6859 Protein S100-A4 S100A4 0.0014
4386 Hemoglobin-like protein HbN glbN 0.0014
4943 Cytochrome c6 petJ 0.0013
4954 Soluble cytochrome b558 Not Available 0.0013
4934 Cytochrome c-551 nirM 0.0013
5218 Cytochrome c-551 nirM 0.0013
4905 Cytochrome c2 Not Available 0.0013
4939 Cytochrome c2 cycA 0.0013
4964 Cytochrome c2 cycA 0.0013
4979 Cytochrome c2 cycA 0.0013
6673 Cytochrome c2 cycA 0.0013
4925 Cytochrome c-type protein SHP shp 0.0013
4947 Bacterial hemoglobin vhb 0.0013
4916 Cyanoglobin glbN 0.0013
4984 Neuroglobin NGB 0.0013
4994 Hemoglobin-like protein HbO glbO 0.0013
4915 Cytochrome c-550 psbV 0.0013
4959 Cytochrome c-550 psbV 0.0013
5216 Cytochrome c-550 psbV 0.0013
4998 Hemoglobin-like protein yjbI yjbI 0.0013
4936 Cytochrome c2 iso-2 Not Available 0.0013
4942 Diheme cytochrome c napB napB 0.0013
4975 Cytochrome c-556 RPA3973 0.0013
4961 Hemophore HasA hasA 0.0013
4910 Cytoglobin CYGB 0.0013
4904 Cytochrome c family protein GSU1996 0.0013
5000 HemO hemO 0.0013
644 Heme oxygenase 2 HMOX2 0.0013
4982 Heme oxygenase 2 pbsA2 0.0013
4981 Iron-starvation protein PigA pigA 0.0013
4909 CooA protein cooA 0.0013
3116 Bacterioferritin bfr 0.0013
4906 Bacterioferritin bfr 0.0013
4965 Bacterioferritin bfr 0.0013
4907 Cytochrome c-L moxG 0.0013
6865 Cytochrome c-L moxG 0.0013
4976 Apocytochrome f petA 0.0013
6407 Apocytochrome f petA 0.0013
4971 Nonaheme cytochrome c hmcA 0.0013
4764 Cytochrome P450 165C4 CYP165C4 0.0013
4989 Cytochrome c551 peroxidase ccp 0.0013
5222 Cytochrome c551 peroxidase ccpA 0.0013
4935 Cytochrome c-554 cycA1 0.0013
4937 Cytochrome oxidase subunit II rcoxA 0.0013
4999 Cytochrome P450 165B3 CYP165B3 0.0013
4926 Heme-based aerotactic transducer hemAT hemAT 0.0013
4960 Putative cytochrome P450-family protein SCO7417 0.0013
4931 Cytochrome P450 167A1 CYP167A1 0.0013
4972 P450cin cinA 0.0013
4993 Hydroxylamine oxidoreductase hao1 0.0013
4922 Cytochrome c, putative SO_4144 0.0013
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0013
4952 Catalase/peroxidase katA 0.0013
4903 Methyl-accepting chemotaxis protein Tar4 0.0013
3093 Catalase HPII katE 0.0013
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0013
6501 Fatty acid-binding protein, liver FABP1 0.0013
2216 Fibroblast growth factor receptor 4 FGFR4 0.0013
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0013
1353 DNA topoisomerase 1 TOP1 0.0013
3552 DNA topoisomerase 1 topA 0.0013
735 Alanine aminotransferase 1 GPT 0.0013
3904 Alanine aminotransferase 2 GPT2 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
765 Indoleamine 2,3-dioxygenase IDO1 0.0013
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0013
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0013
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0013
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0013
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0013
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0013
4034 Glutaredoxin-1 GLRX 0.0013
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0013
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0013
910 Epididymal secretory glutathione peroxidase GPX5 0.0013
4036 Glutathione peroxidase 6 GPX6 0.0013
903 Glutathione S-transferase A5 GSTA5 0.0013
911 Glutathione peroxidase 3 GPX3 0.0013
4037 Hypothetical protein GPX1 0.0013
4297 Hypothetical protein SP_1951 0.0013
4521 Hypothetical protein BC_2969 0.0013
4540 Hypothetical protein TM_1070 0.0013
4555 Hypothetical protein MT1739 0.0013
4569 Hypothetical protein mshD 0.0013
4578 Hypothetical protein PA3270 0.0013
4747 Hypothetical protein PA3967 0.0013
5177 Hypothetical protein TM_0096 0.0013
5194 Hypothetical protein PA1204 0.0013
5240 Hypothetical protein Rv2991 0.0013
5370 Hypothetical protein TM_1158 0.0013
5710 Hypothetical protein Tb927.5.1360 0.0013
1928 Leukotriene C4 synthase LTC4S 0.0013
4029 Microsomal glutathione S-transferase 3 MGST3 0.0013
4032 Microsomal glutathione S-transferase 1 MGST1 0.0013
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0013
4040 Glutathione peroxidase 7 GPX7 0.0013
907 Glutathione peroxidase 2 GPX2 0.0013
906 Glutathione peroxidase 1 GPX1 0.0013
4035 Glutathione S-transferase Mu 5 GSTM5 0.0013
900 Glutathione S-transferase A4 GSTA4 0.0013
4042 Glutathione transferase omega-2 GSTO2 0.0013
4033 S-formylglutathione hydrolase ESD 0.0013
4038 Glutathione peroxidase 4 GPX4 0.0013
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0013
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3221 Cytochrome c4 cc4 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
85 Growth hormone receptor GHR 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0012
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
2298 Cytochrome P450-cam camC 0.0012
5433 UPF0230 protein TM_1468 TM_1468 0.0012
5431 Lipid binding protein Not Available 0.0012
3616 Fatty acid-binding protein, epidermal FABP5 0.0012
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0012
3319 Hydroxyacylglutathione hydrolase HAGH 0.0011
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0011
1063 Signal transducer and activator of transcription 5B STAT5B 0.0011
897 Glutathione S-transferase kappa 1 GSTK1 0.0011
898 Glutathione S-transferase A3 GSTA3 0.0011
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
909 Maleylacetoacetate isomerase GSTZ1 0.0011
899 Glutathione S-transferase Mu 3 GSTM3 0.0011
905 Glutathione transferase omega-1 GSTO1 0.0011
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.001
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
4920 Peroxidase/catalase katG 0.001
283 SEC14-like protein 2 SEC14L2 0.001
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.001
2165 Glutathione S-transferase Mu 2 GSTM2 0.001
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.001
2119 Cytochrome b5 CYB5A 0.001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.001
4990 PpcA ppcA 0.001
4988 Sulfite oxidase, mitochondrial SUOX 0.001
3570 Cytochrome P450 152A1 cypC 0.001
4289 Cytochrome P450 TT_P0059 0.001
6262 Cytochrome P450 staP 0.001
4992 Cytochrome c peroxidase Not Available 0.001
2915 Sensor protein fixL fixL 0.001
4944 Sensor protein fixL fixL 0.001
3375 Acidic cytochrome c3 Not Available 0.001
207 Glutathione synthetase GSS 0.001
5269 Glutathione synthetase gshB 0.001
4385 Cytochrome c' Not Available 0.001
4967 Cytochrome c' cycA 0.001
5038 Cytochrome c' Not Available 0.001
5223 Cytochrome c' cycP 0.001
4813 Heme oxygenase hmuO 0.001
5769 Heme oxygenase Not Available 0.001
6837 Serine/threonine-protein kinase 17B STK17B 0.001
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.001
2230 Catalase CAT 0.001
3249 Catalase katA 0.001
3625 Catalase katA 0.001
4539 Catalase katA 0.001
4941 Catalase katB 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0009
2211 Fatty acid-binding protein, heart FABP3 0.0009
6459 Glycodelin PAEP 0.0009
901 Glutathione S-transferase Mu 4 GSTM4 0.0009
484 Tyrosine-protein kinase ABL2 ABL2 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0009
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0009
1048 Protein S100-A13 S100A13 0.0009
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0009
2226 Protein S100-A12 S100A12 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
76 Nitric-oxide synthase, brain NOS1 0.0009
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0009
6677 Myelin P2 protein PMP2 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
3670 Soluble cytochrome b562 precursor cybC 0.0009
3411 Cytochrome P450 121 cyp121 0.0009
2617 Nitric oxide synthase oxygenase nos 0.0009
2701 Nitric oxide synthase oxygenase nos 0.0009
3291 Cytochrome c-552 cycA 0.0009
4927 Cytochrome c-552 nrfA 0.0009
4938 Cytochrome c-552 cycA 0.0009
4953 Cytochrome c-552 nrfA 0.0009
5217 Cytochrome c-552 cycM 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
3102 Flavohemoprotein hmp 0.0009
4969 Flavohemoprotein hmp 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0008
3404 Exotoxin A eta 0.0008
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0008
1184 Interferon beta IFNB1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
1867 Major prion protein PRNP 0.0008
6599 HTH-type transcriptional regulator ttgR ttgR 0.0008
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
2972 6-deoxyerythronolide B hydroxylase eryF 0.0008
1025 Aquaporin-1 AQP1 0.0008
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0008
1268 Neuropeptide S receptor NPSR1 0.0008
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0008
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0008
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
473 L-lactate dehydrogenase A chain LDHA 0.0007
4608 Putative cytochrome P450 SCO1207 0.0007
4963 Putative cytochrome P450 SCO2884 0.0007
6254 Putative cytochrome P450 SCO6998 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
1360 Sphingomyelin phosphodiesterase SMPD1 0.0007
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0007
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0007
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
358 Cystathionine beta-synthase CBS 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
6073 Potassium channel subfamily K member 9 KCNK9 0.0007
6072 Potassium channel subfamily K member 3 KCNK3 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
4666 Fucose-binding lectin PA-IIL lecB 0.0007
2372 Bifunctional tail protein 9 0.0007
125 DNA polymerase beta POLB 0.0007
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0007
131 Synaptic vesicular amine transporter SLC18A2 0.0007
693 Hemoglobin subunit beta HBB 0.0007
4878 Glycoprotein hormones alpha chain CGA 0.0006
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0006
1072 Granzyme B GZMB 0.0006
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0006
4880 Membrane cofactor protein CD46 0.0006
4889 Ig epsilon chain C region IGHE 0.0006
4877 Beta-mannanase man 0.0006
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0006
4850 Beta-2-glycoprotein 1 APOH 0.0006
4856 CD209 antigen CD209 0.0006
4189 Alpha-galactosidase A GLA 0.0006
4869 Major capsid protein A430L 0.0006
757 Fusion glycoprotein F0 F 0.0006
4875 Fusion glycoprotein F0 F 0.0006
4852 Reticulon-4 receptor RTN4R 0.0006
4845 ADAM 33 ADAM33 0.0006
1354 Beta-glucuronidase GUSB 0.0006
442 Envelope glycoprotein gp41 0.0006
4859 Envelope glycoprotein env 0.0006
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0006
4721 Beta-1,4-mannanase manA 0.0006
3352 Structural polyprotein Not Available 0.0006
3628 Structural polyprotein Not Available 0.0006
4892 Structural polyprotein Not Available 0.0006
144 Hemoglobin subunit alpha HBA1 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
6268 Hydroxyacid oxidase 1 HAO1 0.0006
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0006
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0006
810 Heme oxygenase 1 HMOX1 0.0006
3391 Heme oxygenase 1 pbsA1 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0006
793 T-cell surface antigen CD2 CD2 0.0006
4861 Interleukin-6 receptor alpha chain IL6R 0.0006
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0006
3837 Cytokine receptor common beta chain CSF2RB 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
5221 Cytochrome c3, 13 kDa Not Available 0.0006
3152 Cytochrome c'' cycA 0.0006
5220 Split-Soret cytochrome c Ddes_2150 0.0006
3700 Cytochrome c-552 precursor nrfA 0.0006
2430 Chondroitinase B cslB 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0005
244 Angiotensin-converting enzyme ACE 0.0005
798 Osteocalcin BGLAP 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
6151 Monocarboxylate transporter 10 SLC16A10 0.0005
1379 Interleukin-12 subunit beta IL12B 0.0005
4890 Hemagglutinin HA 0.0005
6566 Hemagglutinin Not Available 0.0005
3127 Nitrite reductase nirS 0.0005
3284 Nitrite reductase nirS 0.0005
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0005
6858 Inactive carboxylesterase 4 CES1P1 0.0005
369 Coagulation factor VII F7 0.0005
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0005
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0004
554 Low-density lipoprotein receptor LDLR 0.0004
852 Heparin cofactor 2 SERPIND1 0.0004
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0004
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0004
1859 Prostatic acid phosphatase ACPP 0.0004
595 Fibrinogen alpha chain FGA 0.0004
3140 Hemagglutinin-neuraminidase HN 0.0004
3609 Hemagglutinin-neuraminidase HN 0.0004
3444 Cyanovirin-N Not Available 0.0004
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0004
4509 Acetoin(diacetyl) reductase budC 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
3689 Endoglucanase A celA 0.0004
3009 Beta-glucanase Not Available 0.0004
5411 Slt-IIvB stxB2e 0.0004
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0004
5563 Galectin-2 LGALS2 0.0004
1875 Pulmonary surfactant-associated protein D SFTPD 0.0004
5569 Endo-1,4-beta glucanase EngF engF 0.0004
5046 Ecotin eco 0.0004
3793 Aspartate ammonia-lyase aspA 0.0004
5554 D-galactose-binding periplasmic protein mglB 0.0004
3741 D-galactose-binding periplasmic protein precursor mglB 0.0004
5568 Endoglucanase C307 celC307 0.0004
5553 Endoglucanase E1 Acel_0614 0.0004
5562 Hexokinase Not Available 0.0004
3744 Endoglucanase SS precursor celS 0.0004
5570 Endoglucanase E-4 celD 0.0004
5559 Neopullulanase nplT 0.0004
4670 Cellulase B celB 0.0004
4668 Laminarinase TM_0024 0.0004
4667 BH0236 protein BH0236 0.0004
4671 Endoglucanase C cenC 0.0004
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0004
309 Antithrombin-III SERPINC1 0.0003
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
5176 YtnJ moxC 0.0003
5416 Coat protein VP1 Not Available 0.0003
2705 Dimethyl sulfoxide reductase dmsA 0.0003
5247 Endo-1,4-beta-xylanase Not Available 0.0003
5248 Endo-1,4-beta-xylanase xlnA 0.0003
5250 Endo-1,4-beta-xylanase xyl 0.0003
4669 Endo-1,4-beta-xylanase A xynA 0.0003
4715 Endo-1,4-beta-xylanase A xlnA 0.0003
5560 Endo-1,4-beta-xylanase A xynA 0.0003
1503 Galectin-7 LGALS7 0.0003
5498 Maltoporin lamB 0.0003
5561 Maltoporin lamB 0.0003
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0003
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.0003
4622 Amylase Not Available 0.0003
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0003
6307 Ig gamma-2 chain C region IGHG2 0.0003
2826 Glucose--fructose oxidoreductase gfo 0.0003
1881 Hexokinase-1 HK1 0.0003
2581 Chondroitinase AC cslA 0.0003
6847 Lactase-phlorizin hydrolase LCT 0.0003
2324 Botulinum neurotoxin type B botB 0.0003
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0003
3747 Cellulase B precursor celB 0.0003
3547 Enterotoxin type B entB 0.0003
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0003
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0003
4819 Hydrolase Not Available 0.0003
5249 Hydrolase Not Available 0.0003
5436 Hydrolase Not Available 0.0003
2531 Alpha-amylase amyE 0.0003
2948 Alpha-amylase amy 0.0003
3169 Alpha-amylase Not Available 0.0003
2541 Neopullulanase 1 tvaI 0.0003
4811 Amylosucrase ams 0.0003
3091 Maltodextrin phosphorylase malP 0.0003
2606 Neopullulanase 2 tvaII 0.0003
4692 A/G-specific adenine glycosylase mutY 0.0003
3225 Shiga toxin B-chain stxB 0.0003
3365 Beta-amylase spoII 0.0003
4830 Aldose 1-epimerase galM 0.0003
6614 Lactase-like protein LCTL 0.0003
1675 Glucokinase GCK 0.0003
4662 Glucokinase glk 0.0003
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0003
3030 Salivary alpha-amylase AMY1A 0.0003
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0003
2508 Cyclomaltodextrin glucanotransferase cgt 0.0003
2523 Cyclomaltodextrin glucanotransferase cgt 0.0003
3207 Cyclomaltodextrin glucanotransferase amyA 0.0003
4272 POSSIBLE CELLULASE CELA1 celA1 0.0003
2570 Tetanus toxin tetX 0.0002
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0002
3668 Maltose-binding periplasmic protein precursor malE 0.0002
2802 Endoglucanase G celCCG 0.0002
2440 Endoglucanase F celCCF 0.0002
2245 Xylose isomerase xylA 0.0002
2253 Xylose isomerase xylA 0.0002
2260 Xylose isomerase xylA 0.0002
2431 Xylose isomerase xylA 0.0002
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0002
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0002
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0002
6168 Solute carrier family 22 member 16 SLC22A16 0.0002
2252 Endoglucanase 5A cel5A 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0002
10 Glycogen phosphorylase, liver form PYGL 0.0002
2723 Cholera enterotoxin subunit B ctxB 0.0002
4513 Pancreatic alpha-amylase AMY2A 0.0002
2427 Ferrichrome-iron receptor fhuA 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
1152 Glycogen phosphorylase, muscle form PYGM 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
↑