DT-Web

DB02079 - (Aminooxy)Acetic Acid


Identification
Name (Aminooxy)Acetic Acid
Accession Number DB02079 (EXPT00528)
Type small molecule
Description A compound that inhibits aminobutyrate aminotransferase activity in vivo, thereby raising the level of gamma-aminobutyric acid in tissues. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 91.066
Groups experimental
Monoisotopic Weight 91.026943031
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Serine--pyruvate aminotransferase
Name Serine--pyruvate aminotransferase
Gene Name AGXT
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.5463

Predictions


Id Partner name Gene Name Score
72 Seryl-tRNA synthetase, cytoplasmic SARS 0.0349
184 L-serine dehydratase SDS 0.0319
431 Serine racemase SRR 0.0319
491 Serine palmitoyltransferase 1 SPTLC1 0.0319
727 Serine palmitoyltransferase 2 SPTLC2 0.0319
6151 Monocarboxylate transporter 10 SLC16A10 0.0301
358 Cystathionine beta-synthase CBS 0.028
5492 Cystathionine gamma-synthase metB 0.027
5491 Methionine gamma-lyase mdeA 0.027
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0226
4823 L-allo-threonine aldolase TM_1744 0.0218
2758 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase bioA 0.0215
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0206
532 Neutral amino acid transporter A SLC1A4 0.0202
4070 Probable alanyl-tRNA synthetase, mitochondrial AARS2 0.0202
323 Alanyl-tRNA synthetase, cytoplasmic AARS 0.0202
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.0197
449 Ornithine decarboxylase ODC1 0.0191
435 Kynureninase KYNU 0.0189
4654 Kynureninase kynU 0.0189
593 Proton-coupled amino acid transporter 1 SLC36A1 0.0186
169 Cysteine desulfurase, mitochondrial NFS1 0.0184
735 Alanine aminotransferase 1 GPT 0.0164
3904 Alanine aminotransferase 2 GPT2 0.0164
2249 Aspartate aminotransferase aspC 0.0159
2671 Aspartate aminotransferase aspC 0.0159
5490 Aspartate aminotransferase Not Available 0.0159
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0143
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.014
1152 Glycogen phosphorylase, muscle form PYGM 0.0134
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0098
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0098
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0098
3884 SHMT2 protein SHMT2 0.0086
3901 SHMT2 protein SHMT2 0.0086
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0086
3879 Serine hydroxymethyltransferase 2 Not Available 0.0086
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0086
4059 Glycine N-acyltransferase-like protein 1 GLYATL1 0.008
4058 Glycine N-acyltransferase-like protein 2 GLYATL2 0.008
4057 Glycine N-acyltransferase GLYAT 0.008
4056 N-arachidonyl glycine receptor GPR18 0.008
4061 Peroxisomal sarcosine oxidase PIPOX 0.008
4055 Bile acid CoA:amino acid N-acyltransferase BAAT 0.008
4060 Vesicular inhibitory amino acid transporter SLC32A1 0.008
1088 5-aminolevulinate synthase, erythroid-specific, mitochondrial ALAS2 0.008
1236 Sodium- and chloride-dependent glycine transporter 1 SLC6A9 0.008
1466 Glycyl-tRNA synthetase GARS 0.008
4062 Sodium- and chloride-dependent glycine transporter 2 SLC6A5 0.008
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0077
4054 Glycine cleavage system H protein, mitochondrial GCSH 0.0066
62 Glycine receptor subunit beta GLRB 0.0061
383 Glycine amidinotransferase, mitochondrial GATM 0.0059
411 Glycine N-methyltransferase GNMT 0.0059
207 Glutathione synthetase GSS 0.0057
5269 Glutathione synthetase gshB 0.0057
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0053
820 Glycine receptor subunit alpha-2 GLRA2 0.005
461 Glycine receptor subunit alpha-3 GLRA3 0.005
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0049
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0045
482 Glycine receptor subunit alpha-1 GLRA1 0.0043
3909 Hepatic peroxysomal alanine:glyoxylate aminotransferase Not Available 0.0043
3914 Alanine-glyoxylate aminotransferase homolog TLH6 0.0037
3911 Uncharacterized protein C20orf38 SPTLC3 0.0035
3881 Selenocysteine lyase variant Not Available 0.0035
3887 Phosphorylase PYGB 0.0035
3908 P-selectin cytoplasmic tail-associated protein pcap 0.0035
3883 Ornithine aminotransferase variant Not Available 0.0035
306 Pyridoxal phosphate phosphatase PDXP 0.0035
3906 Serine dehydratase-like SDSL 0.0034
3896 CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase GADL1 0.0034
3891 Putative L-Dopa decarboxylase DDC 0.0034
3878 GAD1 protein GAD1 0.0034
3915 Cysteine sulfinic acid decarboxylase-related protein 1 CSAD 0.0034
3893 DDC protein DDC 0.0034
3880 Serine hydroxymethyltransferase 1 Not Available 0.0034
3910 O-phosphoseryl-tRNA(Sec) selenium transferase SEPSECS 0.0034
855 Sphingosine-1-phosphate lyase 1 SGPL1 0.0034
3903 Aminolevulinate, delta-, synthase 2 ALAS2 0.0034
664 Glutamate decarboxylase 2 GAD2 0.0034
3890 Glutamate decarboxylase 2 GAD2 0.0034
3886 Migration-inducing protein 4 ALAS1 0.0034
3894 KIAA0251 protein PDXDC1 0.0034
3875 Glycogen phosphorylase, brain form PYGB 0.0034
3882 Brain glycogen phosphorylase variant Not Available 0.0034
3905 Molybdenum cofactor sulfurase MOCOS 0.0034
89 Cysteine sulfinic acid decarboxylase CSAD 0.0032
534 Threonine synthase-like 1 THNSL1 0.0031
3874 Proline synthetase co-transcribed bacterial homolog protein PROSC 0.0031
665 Phosphoserine aminotransferase PSAT1 0.003
4652 Phosphoserine aminotransferase serC 0.003
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.003
420 Glutamate decarboxylase 1 GAD1 0.003
3900 Glutamate decarboxylase 1 GAD1 0.003
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.003
3 Histidine decarboxylase HDC 0.003
499 Arginine decarboxylase ADC 0.003
472 Ornithine aminotransferase, mitochondrial OAT 0.0029
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0029
3913 Glutamic acid decarboxylase GAD65 0.0029
868 Cystathionine gamma-lyase CTH 0.0028
3877 Growth-inhibiting protein 18 GIG18 0.0028
426 Aspartate aminotransferase, mitochondrial GOT2 0.0028
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0027
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0027
763 Tyrosine aminotransferase TAT 0.0026
5493 Tyrosine aminotransferase Not Available 0.0026
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0026
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0024
10 Glycogen phosphorylase, liver form PYGL 0.0023
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0022
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