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DB01699 - (4e)-4-Aminohex-4-Enoic Acid


Identification
Name (4e)-4-Aminohex-4-Enoic Acid
Accession Number DB01699 (EXPT01579)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 129.157
Groups experimental
Monoisotopic Weight 129.078978601
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


4-aminobutyrate aminotransferase, mitochondrial
Name 4-aminobutyrate aminotransferase, mitochondrial
Gene Name ABAT
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.4401

Predictions


Id Partner name Gene Name Score
593 Proton-coupled amino acid transporter 1 SLC36A1 0.0588
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.054
735 Alanine aminotransferase 1 GPT 0.0266
3904 Alanine aminotransferase 2 GPT2 0.0266
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0229
532 Neutral amino acid transporter A SLC1A4 0.0156
323 Alanyl-tRNA synthetase, cytoplasmic AARS 0.0156
4070 Probable alanyl-tRNA synthetase, mitochondrial AARS2 0.0156
6151 Monocarboxylate transporter 10 SLC16A10 0.0154
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.0151
435 Kynureninase KYNU 0.0143
4654 Kynureninase kynU 0.0143
3913 Glutamic acid decarboxylase GAD65 0.0142
169 Cysteine desulfurase, mitochondrial NFS1 0.0142
218 Monocarboxylate transporter 5 SLC16A4 0.0126
738 Monocarboxylate transporter 1 SLC16A1 0.0126
397 Monocarboxylate transporter 3 SLC16A8 0.0126
429 Monocarboxylate transporter 6 SLC16A5 0.0126
195 Monocarboxylate transporter 7 SLC16A6 0.0126
349 Serine--pyruvate aminotransferase AGXT 0.0123
1483 Membrane copper amine oxidase AOC3 0.0112
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.011
52 Pyruvate kinase isozymes R/L PKLR 0.0104
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0102
771 Pyruvate carboxylase, mitochondrial PC 0.0101
98 Pyruvate kinase isozymes M1/M2 PKM2 0.0091
199 Monocarboxylate transporter 8 SLC16A2 0.0087
500 Monocarboxylate transporter 4 SLC16A3 0.0084
489 Monocarboxylate transporter 2 SLC16A7 0.0083
1039 Histone deacetylase 9 HDAC9 0.008
6031 Cytochrome P450 3A43 CYP3A43 0.008
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0074
4118 Cytochrome P450 3A5 CYP3A5 0.0073
4924 Cytochrome P450 2C8 CYP2C8 0.0072
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.007
6016 Cytochrome P450 2C19 CYP2C19 0.0069
3939 Amine oxidase [flavin-containing] B MAOB 0.0067
3941 Amine oxidase [flavin-containing] A MAOA 0.0066
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0064
4512 Cytochrome P450 3A4 CYP3A4 0.0058
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0056
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.005
6013 Cytochrome P450 2E1 CYP2E1 0.005
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.005
665 Phosphoserine aminotransferase PSAT1 0.005
4652 Phosphoserine aminotransferase serC 0.005
420 Glutamate decarboxylase 1 GAD1 0.005
3900 Glutamate decarboxylase 1 GAD1 0.005
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.005
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.005
6107 Cytochrome P450 3A7 CYP3A7 0.005
3877 Growth-inhibiting protein 18 GIG18 0.0046
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0045
426 Aspartate aminotransferase, mitochondrial GOT2 0.0044
763 Tyrosine aminotransferase TAT 0.0044
5493 Tyrosine aminotransferase Not Available 0.0044
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0043
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0042
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.004
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0039
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0039
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0038
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0037
6106 Cytochrome P450 2C18 CYP2C18 0.0037
6143 Solute carrier family 22 member 7 SLC22A7 0.0034
118 Organic cation/carnitine transporter 2 SLC22A5 0.0033
4026 Aspartyl aminopeptidase DNPEP 0.0031
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0031
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0031
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0031
4019 Excitatory amino acid transporter 4 SLC1A6 0.0031
1047 Excitatory amino acid transporter 2 SLC1A2 0.0031
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0031
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0031
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0031
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0031
1912 Excitatory amino acid transporter 1 SLC1A3 0.0031
4016 Excitatory amino acid transporter 5 SLC1A7 0.0031
664 Glutamate decarboxylase 2 GAD2 0.0031
3890 Glutamate decarboxylase 2 GAD2 0.0031
922 Glutamate receptor 4 GRIA4 0.0031
927 Metabotropic glutamate receptor 8 GRM8 0.0031
925 Metabotropic glutamate receptor 4 GRM4 0.0031
926 Metabotropic glutamate receptor 7 GRM7 0.0031
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0031
4020 Glutamyl aminopeptidase ENPEP 0.0031
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0031
4018 Glutamate receptor delta-2 subunit GRID2 0.0031
4027 Glutamate receptor delta-1 subunit GRID1 0.0031
4017 5-oxoprolinase OPLAH 0.0031
6142 Solute carrier family 22 member 8 SLC22A8 0.0031
5718 Cytochrome P450 2A6 CYP2A6 0.003
20 Prostaglandin G/H synthase 1 PTGS1 0.003
1729 Solute carrier family 22 member 6 SLC22A6 0.0028
6030 Cytochrome P450 2B6 CYP2B6 0.0027
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0027
3883 Ornithine aminotransferase variant Not Available 0.0026
3896 CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase GADL1 0.0026
3911 Uncharacterized protein C20orf38 SPTLC3 0.0026
3881 Selenocysteine lyase variant Not Available 0.0026
3887 Phosphorylase PYGB 0.0026
3915 Cysteine sulfinic acid decarboxylase-related protein 1 CSAD 0.0026
3914 Alanine-glyoxylate aminotransferase homolog TLH6 0.0026
3878 GAD1 protein GAD1 0.0026
306 Pyridoxal phosphate phosphatase PDXP 0.0026
3906 Serine dehydratase-like SDSL 0.0026
3891 Putative L-Dopa decarboxylase DDC 0.0026
3903 Aminolevulinate, delta-, synthase 2 ALAS2 0.0026
3880 Serine hydroxymethyltransferase 1 Not Available 0.0026
3908 P-selectin cytoplasmic tail-associated protein pcap 0.0026
3893 DDC protein DDC 0.0026
3910 O-phosphoseryl-tRNA(Sec) selenium transferase SEPSECS 0.0026
855 Sphingosine-1-phosphate lyase 1 SGPL1 0.0026
3886 Migration-inducing protein 4 ALAS1 0.0026
3909 Hepatic peroxysomal alanine:glyoxylate aminotransferase Not Available 0.0026
3894 KIAA0251 protein PDXDC1 0.0026
3875 Glycogen phosphorylase, brain form PYGB 0.0026
3882 Brain glycogen phosphorylase variant Not Available 0.0026
3905 Molybdenum cofactor sulfurase MOCOS 0.0026
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0026
5 Glutaminase liver isoform, mitochondrial GLS2 0.0026
917 Glutaminase kidney isoform, mitochondrial GLS 0.0026
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0026
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0026
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0026
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0026
5261 Phosphoribosylformylglycinamidine synthase purL 0.0026
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0026
625 Glutamate carboxypeptidase 2 FOLH1 0.0025
727 Serine palmitoyltransferase 2 SPTLC2 0.0024
491 Serine palmitoyltransferase 1 SPTLC1 0.0024
89 Cysteine sulfinic acid decarboxylase CSAD 0.0024
184 L-serine dehydratase SDS 0.0024
431 Serine racemase SRR 0.0024
3874 Proline synthetase co-transcribed bacterial homolog protein PROSC 0.0024
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0024
534 Threonine synthase-like 1 THNSL1 0.0024
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0024
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0024
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0024
4200 Cytochrome P450 1A2 CYP1A2 0.0024
3 Histidine decarboxylase HDC 0.0024
1671 Excitatory amino acid transporter 3 SLC1A1 0.0024
916 Metabotropic glutamate receptor 1 GRM1 0.0024
499 Arginine decarboxylase ADC 0.0024
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0023
4757 Cytochrome P450 2C9 CYP2C9 0.0023
923 Glutamate receptor 3 GRIA3 0.0023
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0022
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0022
472 Ornithine aminotransferase, mitochondrial OAT 0.0022
358 Cystathionine beta-synthase CBS 0.0022
3884 SHMT2 protein SHMT2 0.0022
3901 SHMT2 protein SHMT2 0.0022
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0022
3879 Serine hydroxymethyltransferase 2 Not Available 0.0022
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0022
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0022
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0022
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0021
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0021
868 Cystathionine gamma-lyase CTH 0.0021
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0021
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0021
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0021
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.002
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.002
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0019
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0019
449 Ornithine decarboxylase ODC1 0.0019
705 Glutamate receptor 1 GRIA1 0.0019
33 Cystine/glutamate transporter SLC7A11 0.0019
3426 Glutamine synthetase glnA 0.0019
3987 Glutamine synthetase GLUL 0.0019
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0018
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0018
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0018
10 Glycogen phosphorylase, liver form PYGL 0.0017
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0014
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0014
921 Glutamate receptor 2 GRIA2 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
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