DT-Web

DB02142 - Pyridoxamine-5'-Phosphate


Identification
Name Pyridoxamine-5'-Phosphate
Accession Number DB02142 (EXPT02621)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 248.173
Groups experimental
Monoisotopic Weight 248.056208048
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Alanine racemase
Name Alanine racemase
Gene Name alr
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.7374
Glutamate-1-semialdehyde 2,1-aminomutase
Name Glutamate-1-semialdehyde 2,1-aminomutase
Gene Name hemL
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.2356
Histidinol-phosphate aminotransferase
Name Histidinol-phosphate aminotransferase
Gene Name hisC
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.7349
D-alanine aminotransferase
Name D-alanine aminotransferase
Gene Name dat
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8588
Aspartate aminotransferase
Name Aspartate aminotransferase
Gene Name aspC
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.1953
4-aminobutyrate aminotransferase
Name 4-aminobutyrate aminotransferase
Gene Name gabT
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.2365
Kynurenine--oxoglutarate transaminase 1
Name Kynurenine--oxoglutarate transaminase 1
Gene Name CCBL1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7458
Histidinol-phosphate aminotransferase
Name Histidinol-phosphate aminotransferase
Gene Name hisC
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.7349
Branched-chain-amino-acid aminotransferase, mitochondrial
Name Branched-chain-amino-acid aminotransferase, mitochondrial
Gene Name BCAT2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7948
UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase
Name UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase
Gene Name arnB
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.1631

Predictions


Id Partner name Gene Name Score
894 Alanine racemase alr 1.7374
5358 Aminodeoxychorismate lyase pabC 0.4338
472 Ornithine aminotransferase, mitochondrial OAT 0.322
426 Aspartate aminotransferase, mitochondrial GOT2 0.2959
3688 Branched-chain-amino-acid aminotransferase ilvE 0.2681
2249 Aspartate aminotransferase aspC 0.1953
5490 Aspartate aminotransferase Not Available 0.1953
2823 Trypanothione reductase TPR 0.1482
2537 Aromatic-amino-acid aminotransferase tyrB 0.1212
586 Aspartate aminotransferase, cytoplasmic GOT1 0.1108
4802 L-cysteine/cystine lyase C-DES c-des 0.0937
6269 S-phase kinase-associated protein 1 SKP1 0.0873
6151 Monocarboxylate transporter 10 SLC16A10 0.0793
1566 Corticoliberin CRH 0.0759
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0691
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0562
3617 Non-heme chloroperoxidase cpo 0.0538
5426 Non-heme chloroperoxidase cpo 0.0538
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0511
4037 Hypothetical protein GPX1 0.0469
4297 Hypothetical protein SP_1951 0.0469
4521 Hypothetical protein BC_2969 0.0469
4540 Hypothetical protein TM_1070 0.0469
4555 Hypothetical protein MT1739 0.0469
4569 Hypothetical protein mshD 0.0469
4578 Hypothetical protein PA3270 0.0469
4747 Hypothetical protein PA3967 0.0469
5177 Hypothetical protein TM_0096 0.0469
5194 Hypothetical protein PA1204 0.0469
5240 Hypothetical protein Rv2991 0.0469
5370 Hypothetical protein TM_1158 0.0469
5710 Hypothetical protein Tb927.5.1360 0.0469
4532 Gephyrin GPHN 0.0468
3184 3-methyl-2-oxobutanoate hydroxymethyltransferase panB 0.0406
3315 3-methyl-2-oxobutanoate hydroxymethyltransferase panB 0.0406
3179 2-isopropylmalate synthase leuA 0.0406
701 Isoleucine-tRNA synthetase IARS 0.038
4080 Isoleucyl-tRNA synthetase, mitochondrial IARS2 0.0379
546 Isoleucyl-tRNA synthetase, cytoplasmic IARS 0.0379
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0364
5491 Methionine gamma-lyase mdeA 0.0337
5492 Cystathionine gamma-synthase metB 0.0337
501 Leucine carboxyl methyltransferase 1 LCMT1 0.033
3334 Deacetoxycephalosporin C synthetase cefE 0.0329
675 Leucine carboxyl methyltransferase 2 LCMT2 0.0329
846 Leucyl-tRNA synthetase, cytoplasmic LARS 0.0329
227 Probable leucyl-tRNA synthetase, mitochondrial LARS2 0.0329
2183 Fatty acid-binding protein, adipocyte FABP4 0.0322
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.032
4823 L-allo-threonine aldolase TM_1744 0.0271
2758 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase bioA 0.0265
449 Ornithine decarboxylase ODC1 0.0263
349 Serine--pyruvate aminotransferase AGXT 0.0251
489 Monocarboxylate transporter 2 SLC16A7 0.0246
500 Monocarboxylate transporter 4 SLC16A3 0.0246
738 Monocarboxylate transporter 1 SLC16A1 0.0217
199 Monocarboxylate transporter 8 SLC16A2 0.021
1152 Glycogen phosphorylase, muscle form PYGM 0.0187
4819 Hydrolase Not Available 0.017
5249 Hydrolase Not Available 0.017
5436 Hydrolase Not Available 0.017
3122 D-hydantoinase Not Available 0.017
3145 D-hydantoinase hyuA 0.017
3168 Beta-lactamase OXA-1 bla 0.017
3230 Non-ATP-dependent L-selective hydantoinase lhyD 0.017
3292 Alanine racemase, catabolic dadX 0.0148
3237 Beta-lactamase OXA-2 bla 0.0148
4264 Alpha-L-fucosidase, putative TM_0306 0.0148
3281 Isoaspartyl dipeptidase iadA 0.0148
2801 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase murE 0.0136
2983 Methylmalonyl-CoA carboxyltransferase 5S subunit Not Available 0.0136
4549 Endonuclease III HP_0602 0.0129
2646 Dihydroorotase pyrC 0.0129
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0125
917 Glutaminase kidney isoform, mitochondrial GLS 0.0125
5 Glutaminase liver isoform, mitochondrial GLS2 0.0125
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0125
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0125
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0125
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0125
5261 Phosphoribosylformylglycinamidine synthase purL 0.0125
2717 Folylpolyglutamate synthase fgs 0.0123
2340 Beta-lactamase PSE-2 bla 0.0116
2796 Parathion hydrolase opd 0.0115
6539 Parathion hydrolase opd 0.0115
1008 CTP synthase 1 CTPS 0.011
3985 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2 GFPT2 0.011
3990 Protein-glutamine gamma-glutamyltransferase 4 TGM4 0.011
3986 Protein-glutamine gamma-glutamyltransferase 6 TGM6 0.011
3992 Protein-glutamine gamma-glutamyltransferase Z TGM7 0.011
3983 Protein-glutamine gamma-glutamyltransferase 5 TGM5 0.011
3989 Glutaminyl-tRNA synthetase QARS 0.011
3988 Protein-glutamine gamma-glutamyltransferase K TGM1 0.011
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0109
1596 Protein-glutamine gamma-glutamyltransferase 2 TGM2 0.0107
6 Coagulation factor XIII A chain F13A1 0.0103
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.01
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0099
665 Phosphoserine aminotransferase PSAT1 0.0099
4652 Phosphoserine aminotransferase serC 0.0099
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0099
420 Glutamate decarboxylase 1 GAD1 0.0099
3900 Glutamate decarboxylase 1 GAD1 0.0099
2339 Protein-glutamine gamma-glutamyltransferase E TGM3 0.0095
3426 Glutamine synthetase glnA 0.0095
3987 Glutamine synthetase GLUL 0.0095
3971 CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase CAD 0.0094
263 Neutral amino acid transporter B(0) SLC1A5 0.0093
413 Amidophosphoribosyltransferase PPAT 0.0092
2515 Amidophosphoribosyltransferase purF 0.0092
3714 Amidophosphoribosyltransferase purF 0.0092
3877 Growth-inhibiting protein 18 GIG18 0.0089
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0087
314 System N amino acid transporter 1 SLC38A3 0.0086
763 Tyrosine aminotransferase TAT 0.0085
5493 Tyrosine aminotransferase Not Available 0.0085
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0084
3904 Alanine aminotransferase 2 GPT2 0.0083
735 Alanine aminotransferase 1 GPT 0.0083
3911 Uncharacterized protein C20orf38 SPTLC3 0.008
306 Pyridoxal phosphate phosphatase PDXP 0.008
3881 Selenocysteine lyase variant Not Available 0.008
3887 Phosphorylase PYGB 0.008
3908 P-selectin cytoplasmic tail-associated protein pcap 0.008
3915 Cysteine sulfinic acid decarboxylase-related protein 1 CSAD 0.008
3914 Alanine-glyoxylate aminotransferase homolog TLH6 0.008
3906 Serine dehydratase-like SDSL 0.008
3896 CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase GADL1 0.008
3891 Putative L-Dopa decarboxylase DDC 0.008
3909 Hepatic peroxysomal alanine:glyoxylate aminotransferase Not Available 0.008
3883 Ornithine aminotransferase variant Not Available 0.008
3878 GAD1 protein GAD1 0.008
3893 DDC protein DDC 0.008
3880 Serine hydroxymethyltransferase 1 Not Available 0.008
3910 O-phosphoseryl-tRNA(Sec) selenium transferase SEPSECS 0.008
855 Sphingosine-1-phosphate lyase 1 SGPL1 0.008
3903 Aminolevulinate, delta-, synthase 2 ALAS2 0.008
3894 KIAA0251 protein PDXDC1 0.008
3886 Migration-inducing protein 4 ALAS1 0.008
3875 Glycogen phosphorylase, brain form PYGB 0.008
3882 Brain glycogen phosphorylase variant Not Available 0.008
3905 Molybdenum cofactor sulfurase MOCOS 0.008
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0073
534 Threonine synthase-like 1 THNSL1 0.0067
3874 Proline synthetase co-transcribed bacterial homolog protein PROSC 0.0067
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.0067
184 L-serine dehydratase SDS 0.0067
727 Serine palmitoyltransferase 2 SPTLC2 0.0067
431 Serine racemase SRR 0.0067
491 Serine palmitoyltransferase 1 SPTLC1 0.0067
89 Cysteine sulfinic acid decarboxylase CSAD 0.0067
3 Histidine decarboxylase HDC 0.0066
499 Arginine decarboxylase ADC 0.0066
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0066
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0066
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0066
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0066
3913 Glutamic acid decarboxylase GAD65 0.0066
435 Kynureninase KYNU 0.0065
4654 Kynureninase kynU 0.0065
2240 Cell division protein kinase 2 CDK2 0.0064
868 Cystathionine gamma-lyase CTH 0.0062
169 Cysteine desulfurase, mitochondrial NFS1 0.0061
3884 SHMT2 protein SHMT2 0.0059
3901 SHMT2 protein SHMT2 0.0059
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0059
3879 Serine hydroxymethyltransferase 2 Not Available 0.0059
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0059
358 Cystathionine beta-synthase CBS 0.0058
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0056
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0055
10 Glycogen phosphorylase, liver form PYGL 0.0051
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0048
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0037
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0037
664 Glutamate decarboxylase 2 GAD2 0.0037
3890 Glutamate decarboxylase 2 GAD2 0.0037
4026 Aspartyl aminopeptidase DNPEP 0.0037
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0037
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0037
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0037
1912 Excitatory amino acid transporter 1 SLC1A3 0.0037
4016 Excitatory amino acid transporter 5 SLC1A7 0.0037
4019 Excitatory amino acid transporter 4 SLC1A6 0.0037
1047 Excitatory amino acid transporter 2 SLC1A2 0.0037
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0037
926 Metabotropic glutamate receptor 7 GRM7 0.0037
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0037
922 Glutamate receptor 4 GRIA4 0.0037
927 Metabotropic glutamate receptor 8 GRM8 0.0037
925 Metabotropic glutamate receptor 4 GRM4 0.0037
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0037
4020 Glutamyl aminopeptidase ENPEP 0.0037
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0037
4017 5-oxoprolinase OPLAH 0.0037
4027 Glutamate receptor delta-1 subunit GRID1 0.0037
4018 Glutamate receptor delta-2 subunit GRID2 0.0037
625 Glutamate carboxypeptidase 2 FOLH1 0.0032
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0032
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0032
916 Metabotropic glutamate receptor 1 GRM1 0.0029
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0029
923 Glutamate receptor 3 GRIA3 0.0028
1671 Excitatory amino acid transporter 3 SLC1A1 0.0028
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0028
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0028
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0028
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0028
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0027
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0027
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0025
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0025
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0025
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0024
33 Cystine/glutamate transporter SLC7A11 0.0024
705 Glutamate receptor 1 GRIA1 0.0023
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0022
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0022
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0018
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0018
921 Glutamate receptor 2 GRIA2 0.0017
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