DT-Web

DB00125 - L-Arginine


Identification
Name L-Arginine
Accession Number DB00125 (NUTR00014)
Type small molecule
Description An essential amino acid that is physiologically active in the L-form. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 174.201
Groups approved
Monoisotopic Weight 174.111675712
Pharmacology
Indication Used for nutritional supplementation, also for treating dietary shortage or imbalance.
Mechanism of action Many of supplemental L-arginine's activities, including its possible anti-atherogenic actions, may be accounted for by its role as the precursor to nitric oxide or NO. NO is produced by all tissues of the body and plays very important roles in the cardiovascular system, immune system and nervous system. NO is formed from L-arginine via the enzyme nitric oxide synthase or synthetase (NOS), and the effects of NO are mainly mediated by 3,'5' -cyclic guanylate or cyclic GMP. NO activates the enzyme guanylate cyclase, which catalyzes the synthesis of cyclic GMP from guanosine triphosphate or GTP. Cyclic GMP is converted to guanylic acid via the enzyme cyclic GMP phosphodiesterase. NOS is a heme-containing enzyme with some sequences similar to cytochrome P-450 reductase. Several isoforms of NOS exist, two of which are constitutive and one of which is inducible by immunological stimuli. The constitutive NOS found in the vascular endothelium is designated eNOS and that present in the brain, spinal cord and peripheral nervous system is designated nNOS. The form of NOS induced by immunological or inflammatory stimuli is known as iNOS. iNOS may be expressed constitutively in select tissues such as lung epithelium. All the nitric oxide synthases use NADPH (reduced nicotinamide adenine dinucleotide phosphate) and oxygen (O2) as cosubstrates, as well as the cofactors FAD (flavin adenine dinucleotide), FMN (flavin mononucleotide), tetrahydrobiopterin and heme. Interestingly, ascorbic acid appears to enhance NOS activity by increasing intracellular tetrahydrobiopterin. eNOS and nNOS synthesize NO in response to an increased concentration of calcium ions or in some cases in response to calcium-independent stimuli, such as shear stress. In vitro studies of NOS indicate that the Km of the enzyme for L-arginine is in the micromolar range. The concentration of L-arginine in endothelial cells, as well as in other cells, and in plasma is in the millimolar range. What this means is that, under physiological conditions, NOS is saturated with its L-arginine substrate. In other words, L-arginine would not be expected to be rate-limiting for the enzyme, and it would not appear that supraphysiological levels of L-arginine which could occur with oral supplementation of the amino acid^would make any difference with regard to NO production. The reaction would appear to have reached its maximum level. However, in vivo studies have demonstrated that, under certain conditions, e.g. hypercholesterolemia, supplemental L-arginine could enhance endothelial-dependent vasodilation and NO production.
Absorption Absorbed from the lumen of the small intestine into the enterocytes. Absorption is efficient and occurs by an active transport mechanism.
Protein binding Not Available
Biotransformation Some metabolism of L-arginine takes place in the enterocytes. L-arginine not metabolized in the enterocytes enters the portal circulation from whence it is transported to the liver, where again some portion of the amino acid is metabolized.
Route of elimination Not Available
Toxicity Oral supplementation with L-arginine at doses up to 15 grams daily are generally well tolerated. The most common adverse reactions of higher doses from 15 to 30 grams daily are nausea, abdominal cramps and diarrhea. Some may experience these symptoms at lower doses.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Nitric-oxide synthase, endothelial
Name Nitric-oxide synthase, endothelial
Gene Name NOS3
Pharmacological action unknown
Actions Not Available
References
  • Akamine EH, Kawamoto EM, Scavone C, Nigro D, Carvalho MH, de Cassia A Tostes R, Britto LR, Fortes ZB: Correction of endothelial dysfunction in diabetic female rats by tetrahydrobiopterin and chronic insulin. J Vasc Res. 2006;43(4):309-20. Epub 2006 May 8. - Pubmed
  • Gautier C, Mikula I, Nioche P, Martasek P, Raman CS, Slama-Schwok A: Dynamics of NO rebinding to the heme domain of NO synthase-like proteins from bacterial pathogens. Nitric Oxide. 2006 Dec;15(4):312-27. Epub 2006 Apr 5. - Pubmed
  • Yang J, Ji R, Cheng Y, Sun JZ, Jennings LK, Zhang C: L-arginine chlorination results in the formation of a nonselective nitric-oxide synthase inhibitor. J Pharmacol Exp Ther. 2006 Sep;318(3):1044-9. Epub 2006 May 22. - Pubmed
  • Ishikawa T, Harada T, Koi H, Kubota T, Azuma H, Aso T: Identification of arginase in human placental villi. Placenta. 2007 Feb-Mar;28(2-3):133-8. Epub 2006 May 23. - Pubmed
  • Haruna Y, Morita Y, Komai N, Yada T, Sakuta T, Tomita N, Fox DA, Kashihara N: Endothelial dysfunction in rat adjuvant-induced arthritis: vascular superoxide production by NAD(P)H oxidase and uncoupled endothelial nitric oxide synthase. Arthritis Rheum. 2006 Jun;54(6):1847-55. - Pubmed
DTHybrid score 1.4259
Cationic amino acid transporter 3
Name Cationic amino acid transporter 3
Gene Name SLC7A3
Pharmacological action unknown
Actions Not Available
References
  • Rotmann A, Simon A, Martine U, Habermeier A, Closs EI: Activation of classical protein kinase C decreases transport via systems y+ and y+L. Am J Physiol Cell Physiol. 2007 Jun;292(6):C2259-68. Epub 2007 Feb 28. - Pubmed
  • Huang Y, Kang BN, Tian J, Liu Y, Luo HR, Hester L, Snyder SH: The cationic amino acid transporters CAT1 and CAT3 mediate NMDA receptor activation-dependent changes in elaboration of neuronal processes via the mammalian target of rapamycin mTOR pathway. J Neurosci. 2007 Jan 17;27(3):449-58. - Pubmed
DTHybrid score 0.7201
Arginine decarboxylase
Name Arginine decarboxylase
Gene Name ADC
Pharmacological action unknown
Actions Not Available
References
  • Kotil K, Kuscuoglu U, Kirali M, Uzun H, Akcetin M, Bilge T: Investigation of the dose-dependent neuroprotective effects of agmatine in experimental spinal cord injury: a prospective randomized and placebo-control trial. J Neurosurg Spine. 2006 May;4(5):392-9. - Pubmed
  • Regunathan S: Agmatine: biological role and therapeutic potentials in morphine analgesia and dependence. AAPS J. 2006 Jul 21;8(3):E479-84. - Pubmed
  • Yang HQ, Gao HJ: [Physiological function of arginine and its metabolites in plants] Zhi Wu Sheng Li Yu Fen Zi Sheng Wu Xue Xue Bao. 2007 Feb;33(1):1-8. - Pubmed
  • Wu N, Su RB, Li J: Agmatine and Imidazoline Receptors: Their Role in Opioid Analgesia, Tolerance and Dependence. Cell Mol Neurobiol. 2007 Jul 25;. - Pubmed
DTHybrid score 0.318
Argininosuccinate lyase
Name Argininosuccinate lyase
Gene Name ASL
Pharmacological action unknown
Actions Not Available
References
  • Moradi H, Kwok V, Vaziri ND: Effect of chronic renal failure on arginase and argininosuccinate synthetase expression. Am J Nephrol. 2006;26(3):310-8. Epub 2006 Jun 29. - Pubmed
  • Bizzoco E, Vannucchi MG, Faussone-Pellegrini MS: Transient ischemia increases neuronal nitric oxide synthase, argininosuccinate synthetase and argininosuccinate lyase co-expression in rat striatal neurons. Exp Neurol. 2007 Mar;204(1):252-9. Epub 2007 Jan 2. - Pubmed
  • Mages W, Heinrich O, Treuner G, Vlcek D, Daubnerova I, Slaninova M: Complementation of the Chlamydomonas reinhardtii arg7-8 (arg2) Point Mutation by Recombination with a Truncated Nonfunctional ARG7 Gene. Protist. 2007 Oct;158(4):435-46. Epub 2007 Jul 3. - Pubmed
  • Tischner R, Galli M, Heimer YM, Bielefeld S, Okamoto M, Mack A, Crawford NM: Interference with the citrulline-based nitric oxide synthase assay by argininosuccinate lyase activity in Arabidopsis extracts. FEBS J. 2007 Aug;274(16):4238-45. Epub 2007 Jul 25. - Pubmed
  • Mori M: Regulation of nitric oxide synthesis and apoptosis by arginase and arginine recycling. J Nutr. 2007 Jun;137(6 Suppl 2):1616S-1620S. - Pubmed
DTHybrid score 0.6055
Nitric oxide synthase, inducible
Name Nitric oxide synthase, inducible
Gene Name NOS2
Pharmacological action unknown
Actions Not Available
References
  • Cui YY, Tang CS, Geng B: [Restraint stress down-regulates L-Arg/NOS/NO pathway of platelet and aortic intima in rats] Beijing Da Xue Xue Bao. 2006 Jun 18;38(3):231-5. - Pubmed
  • Devan BD, Pistell PJ, Daffin LW Jr, Nelson CM, Duffy KB, Bowker JL, Bharati IS, Sierra-Mercado D, Spangler EL, Ingram DK: Sildenafil citrate attenuates a complex maze impairment induced by intracerebroventricular infusion of the NOS inhibitor Nomega-nitro-L-arginine methyl ester. Eur J Pharmacol. 2007 Jun 1;563(1-3):134-40. Epub 2007 Feb 17. - Pubmed
  • Rotoli BM, Dall'asta V, Barilli A, D'Ippolito R, Tipa A, Olivieri D, Gazzola GC, Bussolati O: Alveolar macrophages from normal subjects lack the NOS-related system y+ for arginine transport. Am J Respir Cell Mol Biol. 2007 Jul;37(1):105-12. Epub 2007 Mar 15. - Pubmed
  • Kagemann G, Sies H, Schnorr O: Limited availability of L: -arginine increases DNA-binding activity of NF-kappaB and contributes to regulation of iNOS expression. J Mol Med. 2007 Jul;85(7):723-32. Epub 2007 Mar 6. - Pubmed
  • Popovic PJ, Zeh HJ 3rd, Ochoa JB: Arginine and immunity. J Nutr. 2007 Jun;137(6 Suppl 2):1681S-1686S. - Pubmed
DTHybrid score 1.4619
High-affinity cationic amino acid transporter 1
Name High-affinity cationic amino acid transporter 1
Gene Name SLC7A1
Pharmacological action unknown
Actions Not Available
References
  • Yang Z, Venardos K, Jones E, Morris BJ, Chin-Dusting J, Kaye DM: Identification of a novel polymorphism in the 3'UTR of the L-arginine transporter gene SLC7A1: contribution to hypertension and endothelial dysfunction. Circulation. 2007 Mar 13;115(10):1269-74. Epub 2007 Feb 26. - Pubmed
  • Rotmann A, Simon A, Martine U, Habermeier A, Closs EI: Activation of classical protein kinase C decreases transport via systems y+ and y+L. Am J Physiol Cell Physiol. 2007 Jun;292(6):C2259-68. Epub 2007 Feb 28. - Pubmed
  • Vasquez R, Farias M, Vega JL, Martin RS, Vecchiola A, Casanello P, Sobrevia L: D-glucose stimulation of L-arginine transport and nitric oxide synthesis results from activation of mitogen-activated protein kinases p42/44 and Smad2 requiring functional type II TGF-beta receptors in human umbilical vein endothelium. J Cell Physiol. 2007 Sep;212(3):626-32. - Pubmed
  • Cerec V, Piquet-Pellorce C, Aly HA, Touzalin AM, Jegou B, Bauche F: Multiple pathways for cationic amino Acid transport in rat seminiferous tubule cells. Biol Reprod. 2007 Feb;76(2):241-9. Epub 2006 Oct 25. - Pubmed
  • Rotoli BM, Dall'asta V, Barilli A, D'Ippolito R, Tipa A, Olivieri D, Gazzola GC, Bussolati O: Alveolar macrophages from normal subjects lack the NOS-related system y+ for arginine transport. Am J Respir Cell Mol Biol. 2007 Jul;37(1):105-12. Epub 2007 Mar 15. - Pubmed
DTHybrid score 0.7202
Arginase-2, mitochondrial
Name Arginase-2, mitochondrial
Gene Name ARG2
Pharmacological action unknown
Actions Not Available
References
  • Topal G, Brunet A, Walch L, Boucher JL, David-Dufilho M: Mitochondrial arginase II modulates nitric-oxide synthesis through nonfreely exchangeable L-arginine pools in human endothelial cells. J Pharmacol Exp Ther. 2006 Sep;318(3):1368-74. Epub 2006 Jun 26. - Pubmed
  • Hood HM, Spevak CC, Sachs MS: Evolutionary changes in the fungal carbamoyl-phosphate synthetase small subunit gene and its associated upstream open reading frame. Fungal Genet Biol. 2007 Feb;44(2):93-104. Epub 2006 Sep 18. - Pubmed
DTHybrid score 0.7389
Cationic amino acid transporter 4
Name Cationic amino acid transporter 4
Gene Name SLC7A4
Pharmacological action unknown
Actions Not Available
References
  • Rotmann A, Simon A, Martine U, Habermeier A, Closs EI: Activation of classical protein kinase C decreases transport via systems y+ and y+L. Am J Physiol Cell Physiol. 2007 Jun;292(6):C2259-68. Epub 2007 Feb 28. - Pubmed
DTHybrid score 0.7154
Argininosuccinate synthase
Name Argininosuccinate synthase
Gene Name ASS1
Pharmacological action unknown
Actions Not Available
References
  • Feun L, Savaraj N: Pegylated arginine deiminase: a novel anticancer enzyme agent. Expert Opin Investig Drugs. 2006 Jul;15(7):815-22. - Pubmed
  • Moradi H, Kwok V, Vaziri ND: Effect of chronic renal failure on arginase and argininosuccinate synthetase expression. Am J Nephrol. 2006;26(3):310-8. Epub 2006 Jun 29. - Pubmed
  • Cheng PN, Lam TL, Lam WM, Tsui SM, Cheng AW, Lo WH, Leung YC: Pegylated recombinant human arginase (rhArg-peg5,000mw) inhibits the in vitro and in vivo proliferation of human hepatocellular carcinoma through arginine depletion. Cancer Res. 2007 Jan 1;67(1):309-17. - Pubmed
  • Szlosarek PW, Grimshaw MJ, Wilbanks GD, Hagemann T, Wilson JL, Burke F, Stamp G, Balkwill FR: Aberrant regulation of argininosuccinate synthetase by TNF-alpha in human epithelial ovarian cancer. Int J Cancer. 2007 Jul 1;121(1):6-11. - Pubmed
DTHybrid score 0.3305

Transporters


Organic cation/carnitine transporter 2
Name Organic cation/carnitine transporter 2
Gene Name SLC22A5
Actions inhibitor
References
  • Ohashi R, Tamai I, Yabuuchi H, Nezu JI, Oku A, Sai Y, Shimane M, Tsuji A: Na(+)-dependent carnitine transport by organic cation transporter (OCTN2): its pharmacological and toxicological relevance. J Pharmacol Exp Ther. 1999 Nov;291(2):778-84. - Pubmed
DTHybrid score 0.3726
Monocarboxylate transporter 10
Name Monocarboxylate transporter 10
Gene Name SLC16A10
Actions inhibitor
References
  • Kim DK, Kanai Y, Chairoungdua A, Matsuo H, Cha SH, Endou H: Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. J Biol Chem. 2001 May 18;276(20):17221-8. Epub 2001 Feb 20. - Pubmed
DTHybrid score 0.5928
Organic cation/carnitine transporter 1
Name Organic cation/carnitine transporter 1
Gene Name SLC22A4
Actions inhibitor
References
  • Yabuuchi H, Tamai I, Nezu J, Sakamoto K, Oku A, Shimane M, Sai Y, Tsuji A: Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J Pharmacol Exp Ther. 1999 May;289(2):768-73. - Pubmed
DTHybrid score 0.435

Predictions


Id Partner name Gene Name Score
619 Low-affinity cationic amino acid transporter 2 SLC7A2 0.4244
865 Argininosuccinate synthase ASS1 0.3305
2680 Argininosuccinate synthase argG 0.3305
3194 Argininosuccinate synthase argG 0.3305
76 Nitric-oxide synthase, brain NOS1 0.3155
315 Arginase-1 ARG1 0.2986
221 Lysyl-tRNA synthetase KARS 0.2934
3980 Ornithine decarboxylase antizyme 2 OAZ2 0.1833
3981 Ornithine decarboxylase antizyme 3 OAZ3 0.1833
285 Mitochondrial ornithine transporter 2 SLC25A2 0.1833
410 Ornithine decarboxylase antizyme OAZ1 0.1832
224 Mitochondrial ornithine transporter 1 SLC25A15 0.1832
336 Ornithine carbamoyltransferase, mitochondrial OTC 0.1593
472 Ornithine aminotransferase, mitochondrial OAT 0.1215
383 Glycine amidinotransferase, mitochondrial GATM 0.1198
6145 Solute carrier family 22 member 1 SLC22A1 0.0713
6144 Solute carrier family 22 member 2 SLC22A2 0.0701
4119 Cytochrome P450 2D6 CYP2D6 0.0574
828 Phenylalanine-4-hydroxylase PAH 0.0547
3109 Phenylalanine-4-hydroxylase phhA 0.0547
6147 Solute carrier family 22 member 3 SLC22A3 0.0468
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0446
6142 Solute carrier family 22 member 8 SLC22A8 0.0435
843 NG,NG-dimethylarginine dimethylaminohydrolase 1 DDAH1 0.0429
670 NG,NG-dimethylarginine dimethylaminohydrolase 2 DDAH2 0.0429
4066 Protein-arginine deiminase type-1 PADI1 0.0428
4068 Protein-arginine deiminase type-2 PADI2 0.0428
4067 Protein-arginine deiminase type-3 PADI3 0.0428
4065 Protein-arginine deiminase type-6 PADI6 0.0428
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.042
1566 Corticoliberin CRH 0.0413
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0409
4512 Cytochrome P450 3A4 CYP3A4 0.038
1588 Multidrug resistance protein 1 ABCB1 0.038
1729 Solute carrier family 22 member 6 SLC22A6 0.0373
1814 Protein-arginine deiminase type-4 PADI4 0.0364
4200 Cytochrome P450 1A2 CYP1A2 0.0341
134 Tryptophan 5-hydroxylase 1 TPH1 0.0338
676 Tyrosine 3-monooxygenase TH 0.0335
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0332
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0326
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0305
2617 Nitric oxide synthase oxygenase nos 0.0285
2701 Nitric oxide synthase oxygenase nos 0.0285
2532 Pantoate--beta-alanine ligase panC 0.0285
477 DNA topoisomerase 4 subunit A parC 0.0283
886 DNA topoisomerase 4 subunit A parC 0.0283
6226 DNA topoisomerase 4 subunit A parC 0.0283
404 DNA gyrase subunit A gyrA 0.0279
6224 DNA gyrase subunit A gyrA 0.0279
3977 ASRGL1 protein ASRGL1 0.0271
449 Ornithine decarboxylase ODC1 0.0265
199 Monocarboxylate transporter 8 SLC16A2 0.0258
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0249
817 DNA topoisomerase 2-alpha TOP2A 0.0247
6645 D-amino-acid oxidase DAO 0.0245
763 Tyrosine aminotransferase TAT 0.024
5493 Tyrosine aminotransferase Not Available 0.024
3877 Growth-inhibiting protein 18 GIG18 0.024
534 Threonine synthase-like 1 THNSL1 0.0239
5925 Neuropeptide Y NPY 0.0231
314 System N amino acid transporter 1 SLC38A3 0.0229
426 Aspartate aminotransferase, mitochondrial GOT2 0.0224
298 Renin REN 0.0221
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0216
2632 Adenylosuccinate synthetase purA 0.0211
3323 Adenylosuccinate synthetase purA 0.0211
3975 Adenylosuccinate synthetase ADSS 0.0211
4598 Adenylosuccinate synthetase Adss 0.0211
6817 Adenylosuccinate synthetase purA 0.0211
209 Aspartoacylase ASPA 0.021
3979 Aspartoacylase-2 ACY3 0.021
533 Aminoacylase-1 ACY1 0.021
3969 Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole- succinocarboxamide synthase PAICS 0.021
3972 Adenylosuccinate synthetase isozyme 2 ADSS 0.021
3976 Aspartyl-tRNA synthetase, mitochondrial DARS2 0.021
799 Aspartyl-tRNA synthetase, cytoplasmic DARS 0.021
513 Calcium-binding mitochondrial carrier protein Aralar2 SLC25A13 0.021
305 Mitochondrial aspartate-glutamate carrier protein SLC25A13 0.021
262 Calcium-binding mitochondrial carrier protein Aralar1 SLC25A12 0.021
2429 Putrescine-binding periplasmic protein potF 0.0206
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0205
3 Histidine decarboxylase HDC 0.0204
1024 Solute carrier family 22 member 11 SLC22A11 0.0202
862 Multidrug resistance-associated protein 1 ABCC1 0.02
738 Monocarboxylate transporter 1 SLC16A1 0.0198
864 Gag-Pol polyprotein gag-pol 0.0197
2237 Gag-Pol polyprotein gag-pol 0.0197
2326 Gag-Pol polyprotein gag-pol 0.0197
2451 Gag-Pol polyprotein gag-pol 0.0197
2901 Gag-Pol polyprotein gag-pol 0.0197
3165 Gag-Pol polyprotein gag-pol 0.0197
3722 Gag-Pol polyprotein gag-pol 0.0197
6306 Gag-Pol polyprotein gag-pol 0.0197
6624 Gag-Pol polyprotein gag-pol 0.0197
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0197
4069 Threonyl-tRNA synthetase, mitochondrial TARS2 0.0197
261 Threonyl-tRNA synthetase, cytoplasmic TARS 0.0197
246 Valyl-tRNA synthetase VARS 0.0196
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0195
492 Histamine H1 receptor HRH1 0.0192
51 Muscarinic acetylcholine receptor M3 CHRM3 0.019
358 Cystathionine beta-synthase CBS 0.0189
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0186
3971 CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase CAD 0.0185
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0183
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0179
4757 Cytochrome P450 2C9 CYP2C9 0.0179
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0179
349 Serine--pyruvate aminotransferase AGXT 0.0178
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0178
5443 UPF0189 protein ymdB ymdB 0.0171
5446 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase HI_1679 0.0171
5440 UPF0067 protein yebR yebR 0.0171
2720 Copper-containing nitrite reductase nirK 0.0171
4705 Manganese catalase Not Available 0.0171
5449 Hypothetical gliding protein mglB 0.0171
5448 Ribonuclease Z rnz 0.0171
3781 Thiol:disulfide interchange protein dsbC precursor dsbC 0.0171
5439 33 kDa chaperonin hslO 0.0171
5454 Internalin-A inlA 0.0171
5447 Lethal(3)malignant brain tumor-like protein L3MBTL1 0.0171
1671 Excitatory amino acid transporter 3 SLC1A1 0.0169
5469 Head decoration protein shp 0.0168
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0168
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0168
6030 Cytochrome P450 2B6 CYP2B6 0.0168
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0166
6447 Guanine nucleotide-binding protein G(t) subunit alpha-1 GNAT1 0.0164
184 L-serine dehydratase SDS 0.0163
431 Serine racemase SRR 0.0163
491 Serine palmitoyltransferase 1 SPTLC1 0.0163
727 Serine palmitoyltransferase 2 SPTLC2 0.0163
4498 Ornithine cyclodeaminase PP3533 0.016
2457 Bacillolysin nprS 0.016
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0159
169 Cysteine desulfurase, mitochondrial NFS1 0.0159
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0158
6016 Cytochrome P450 2C19 CYP2C19 0.0158
601 Propionyl-CoA carboxylase beta chain, mitochondrial PCCB 0.0157
3356 Diaminopimelate decarboxylase lysA 0.0154
159 Penicillin-binding protein 2B penA 0.0153
6121 Penicillin-binding protein 2B penA 0.0153
4771 Dissimilatory copper-containing nitrite reductase nir 0.0153
3274 Hydroxylamine reductase hcp 0.0153
4804 Hydroxylamine reductase hcp 0.0153
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0152
5450 Prolyl endopeptidase Pep pep 0.0151
2714 Chorismate mutase aroH 0.0151
4611 Chorismate mutase aroG 0.0151
5682 Ribonuclease pancreatic RNASE1 0.015
474 Acetylcholinesterase ACHE 0.0148
815 Histidyl-tRNA synthetase, cytoplasmic HARS 0.0147
96 Histidine ammonia-lyase HAL 0.0147
6257 Histidine ammonia-lyase Not Available 0.0147
6536 Histidine ammonia-lyase hutH 0.0147
776 Bile salt export pump ABCB11 0.0147
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0144
3923 Cholinesterase BCHE 0.0144
4924 Cytochrome P450 2C8 CYP2C8 0.0144
3560 Gentamicin 3'-acetyltransferase aacC1 0.0143
6024 Cytochrome P450 1A1 CYP1A1 0.0142
38 Cystinosin CTNS 0.0141
3998 B(0,+)-type amino acid transporter 1 SLC7A9 0.0141
1963 Neutral and basic amino acid transport protein rBAT SLC3A1 0.0141
3399 Limonene-1,2-epoxide hydrolase limA 0.0139
4608 Putative cytochrome P450 SCO1207 0.0138
4963 Putative cytochrome P450 SCO2884 0.0138
6254 Putative cytochrome P450 SCO6998 0.0138
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0138
4118 Cytochrome P450 3A5 CYP3A5 0.0138
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.0137
3462 Tyrosine-protein kinase transforming protein Abl ABL 0.0136
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0136
6013 Cytochrome P450 2E1 CYP2E1 0.0134
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0134
6107 Cytochrome P450 3A7 CYP3A7 0.0133
5180 L(+)-mandelate dehydrogenase mdlB 0.0132
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.0131
3500 Putative family 31 glucosidase yicI yicI 0.0129
597 Dihydropteridine reductase QDPR 0.0129
3978 Adenylosuccinate synthetase isozyme 1 ADSSL1 0.0129
2675 Pteridine reductase 1 PTR1 0.0128
2472 Voltage-gated potassium channel kcsA 0.0128
6366 Voltage-gated potassium channel kcsA 0.0128
624 Guanidinoacetate N-methyltransferase GAMT 0.0128
89 Cysteine sulfinic acid decarboxylase CSAD 0.0127
5718 Cytochrome P450 2A6 CYP2A6 0.0127
399 Tyrosyl-tRNA synthetase, mitochondrial YARS2 0.0127
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0126
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0125
3480 Mannan endo-1,4-beta-mannosidase manA 0.0125
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0124
3947 Xanthine dehydrogenase/oxidase XDH 0.0124
1615 Chymase CMA1 0.0123
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0123
340 Apoptotic protease-activating factor 1 APAF1 0.0122
2597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] glmS 0.012
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.012
629 Alpha-2B adrenergic receptor ADRA2B 0.0119
435 Kynureninase KYNU 0.0119
4654 Kynureninase kynU 0.0119
263 Neutral amino acid transporter B(0) SLC1A5 0.0119
500 Monocarboxylate transporter 4 SLC16A3 0.0119
735 Alanine aminotransferase 1 GPT 0.0118
3904 Alanine aminotransferase 2 GPT2 0.0118
587 Serum albumin ALB 0.0117
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0115
3874 Proline synthetase co-transcribed bacterial homolog protein PROSC 0.0115
365 Dihydrofolate reductase DHFR 0.0115
2381 Dihydrofolate reductase DFR1 0.0115
2833 Dihydrofolate reductase Not Available 0.0115
2931 Dihydrofolate reductase folA 0.0115
3544 Dihydrofolate reductase folA 0.0115
3682 Dihydrofolate reductase folA 0.0115
6642 Dihydrofolate reductase folA 0.0115
6756 Dihydrofolate reductase dfrA 0.0115
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0114
825 Arsenical pump-driving ATPase ASNA1 0.0114
3435 Arsenical pump-driving ATPase arsA 0.0114
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0114
733 Activin receptor type 1B ACVR1B 0.0114
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0114
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0114
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0114
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0114
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0114
154 AFG3-like protein 2 AFG3L2 0.0114
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0114
395 ALK tyrosine kinase receptor Not Available 0.0114
287 Beta-1,4-galactosyltransferase 1 B4GALT1 0.0113
6168 Solute carrier family 22 member 16 SLC22A16 0.011
701 Isoleucine-tRNA synthetase IARS 0.011
546 Isoleucyl-tRNA synthetase, cytoplasmic IARS 0.011
4080 Isoleucyl-tRNA synthetase, mitochondrial IARS2 0.011
6143 Solute carrier family 22 member 7 SLC22A7 0.0109
3911 Uncharacterized protein C20orf38 SPTLC3 0.0108
3881 Selenocysteine lyase variant Not Available 0.0108
3908 P-selectin cytoplasmic tail-associated protein pcap 0.0108
3914 Alanine-glyoxylate aminotransferase homolog TLH6 0.0108
3883 Ornithine aminotransferase variant Not Available 0.0108
306 Pyridoxal phosphate phosphatase PDXP 0.0108
3906 Serine dehydratase-like SDSL 0.0108
3896 CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase GADL1 0.0108
3891 Putative L-Dopa decarboxylase DDC 0.0108
3915 Cysteine sulfinic acid decarboxylase-related protein 1 CSAD 0.0108
3909 Hepatic peroxysomal alanine:glyoxylate aminotransferase Not Available 0.0108
3903 Aminolevulinate, delta-, synthase 2 ALAS2 0.0108
3878 GAD1 protein GAD1 0.0108
3887 Phosphorylase PYGB 0.0108
3893 DDC protein DDC 0.0108
3880 Serine hydroxymethyltransferase 1 Not Available 0.0108
3910 O-phosphoseryl-tRNA(Sec) selenium transferase SEPSECS 0.0108
3894 KIAA0251 protein PDXDC1 0.0108
3905 Molybdenum cofactor sulfurase MOCOS 0.0108
3886 Migration-inducing protein 4 ALAS1 0.0108
3875 Glycogen phosphorylase, brain form PYGB 0.0108
3882 Brain glycogen phosphorylase variant Not Available 0.0108
855 Sphingosine-1-phosphate lyase 1 SGPL1 0.0108
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0108
4092 Probable asparaginyl-tRNA synthetase, mitochondrial NARS2 0.0107
669 Asparaginyl-tRNA synthetase, cytoplasmic NARS 0.0107
2360 Dihydroneopterin aldolase folB 0.0107
318 Alpha-2A adrenergic receptor ADRA2A 0.0107
378 Alpha-2C adrenergic receptor ADRA2C 0.0105
633 Penicillin-binding proteins 1A/1B pbpA 0.0104
6106 Cytochrome P450 2C18 CYP2C18 0.0103
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0103
868 Cystathionine gamma-lyase CTH 0.0103
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0103
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0103
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0103
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0103
2939 Peptide methionine sulfoxide reductase msrA msrA 0.0102
2888 DNA-repair protein XRCC4 XRCC4 0.0102
2906 Coatomer subunit gamma COPG 0.0102
822 Aldose reductase AKR1B1 0.0102
5650 NimA-related protein DR_0842 0.0101
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0101
115 Penicillin-binding protein 2 mrdA 0.0099
6069 Penicillin-binding protein 2 mrdA 0.0099
6118 Penicillin-binding protein 2 penA 0.0099
6187 Penicillin-binding protein 2 pbpA 0.0099
6686 Penicillin-binding protein 2 pbp2 0.0099
6939 Penicillin-binding protein 2 mrdA 0.0099
7163 Penicillin-binding protein 2 pbpA 0.0099
72 Seryl-tRNA synthetase, cytoplasmic SARS 0.0099
33 Cystine/glutamate transporter SLC7A11 0.0098
5126 Arginase rocF 0.0098
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0098
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0098
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0098
297 Adenylate cyclase type 1 ADCY1 0.0098
489 Monocarboxylate transporter 2 SLC16A7 0.0097
501 Leucine carboxyl methyltransferase 1 LCMT1 0.0097
675 Leucine carboxyl methyltransferase 2 LCMT2 0.0097
846 Leucyl-tRNA synthetase, cytoplasmic LARS 0.0097
227 Probable leucyl-tRNA synthetase, mitochondrial LARS2 0.0097
303 Diamine acetyltransferase 2 SAT2 0.0096
1317 Spermine synthase SMS 0.0096
623 Spermine oxidase SMOX 0.0096
42 Phenylalanyl-tRNA synthetase alpha chain FARSA 0.0096
6602 Phenylalanyl-tRNA synthetase alpha chain pheS 0.0096
31 Phenylalanyl-tRNA synthetase, mitochondrial FARS2 0.0096
618 Phenylalanyl-tRNA synthetase beta chain FARSB 0.0096
6603 Phenylalanyl-tRNA synthetase beta chain pheT 0.0096
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0095
665 Phosphoserine aminotransferase PSAT1 0.0095
4652 Phosphoserine aminotransferase serC 0.0095
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0095
420 Glutamate decarboxylase 1 GAD1 0.0095
3900 Glutamate decarboxylase 1 GAD1 0.0095
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0095
482 Glycine receptor subunit alpha-1 GLRA1 0.0093
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0093
292 Activin receptor type-1 ACVR1 0.0093
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0093
20 Prostaglandin G/H synthase 1 PTGS1 0.0093
849 Activated CDC42 kinase 1 TNK2 0.0093
1757 Myeloperoxidase MPO 0.0092
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0092
6137 Multidrug resistance-associated protein 6 ABCC6 0.0092
3884 SHMT2 protein SHMT2 0.0091
3901 SHMT2 protein SHMT2 0.0091
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0091
3879 Serine hydroxymethyltransferase 2 Not Available 0.0091
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0091
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0091
2090 Toll-like receptor 2 TLR2 0.0091
6010 Thiamine transporter 1 SLC19A2 0.0089
256 Tyrosyl-tRNA synthetase, cytoplasmic YARS 0.0089
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0087
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0087
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0087
123 Diamine acetyltransferase 1 SAT1 0.0086
3913 Glutamic acid decarboxylase GAD65 0.0086
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0085
484 Tyrosine-protein kinase ABL2 ABL2 0.0084
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0083
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0083
904 Glutathione S-transferase P GSTP1 0.0083
1 Peptidoglycan synthetase ftsI ftsI 0.0083
4155 Peptidoglycan synthetase ftsI ftsI 0.0083
2433 Capsid protein P40 UL80 0.0082
3569 Capsid protein P40 BVRF2 0.0082
175 Thiamin pyrophosphokinase 1 TPK1 0.008
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0078
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0077
867 Penicillin-binding protein 3 pbpC 0.0077
6119 Penicillin-binding protein 3 pbp3 0.0077
7154 Penicillin-binding protein 3 pbp3 0.0077
7157 Penicillin-binding protein 3 LMHCC_2184 0.0077
7162 Penicillin-binding protein 3 pbpB 0.0077
7172 Penicillin-binding protein 3 pbp3 0.0077
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0077
6021 Adenosine kinase ADK 0.0075
556 Alpha-1A adrenergic receptor ADRA1A 0.0075
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0074
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0074
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0074
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0073
90 Tryptophan 5-hydroxylase 2 TPH2 0.0073
1636 Trace amine-associated receptor 1 TAAR1 0.0073
4063 Tryptophanyl-tRNA synthetase, mitochondrial WARS2 0.0073
551 Carnitine O-acetyltransferase CRAT 0.0073
193 Beta-1 adrenergic receptor ADRB1 0.0073
6141 Sodium/bile acid cotransporter SLC10A1 0.0073
645 Penicillin-binding protein 1A mrcA 0.0073
5805 Penicillin-binding protein 1A ponA 0.0073
6185 Penicillin-binding protein 1A mrcA 0.0073
6799 Penicillin-binding protein 1A pbpA 0.0073
661 ADP/ATP translocase 1 SLC25A4 0.0072
789 Alpha-1D adrenergic receptor ADRA1D 0.0071
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0071
766 Beta-2 adrenergic receptor ADRB2 0.0071
976 Platelet glycoprotein IX GP9 0.007
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0069
2297 Genome polyprotein Not Available 0.0069
2322 Genome polyprotein Not Available 0.0069
2694 Genome polyprotein Not Available 0.0069
2719 Genome polyprotein Not Available 0.0069
2860 Genome polyprotein Not Available 0.0069
2928 Genome polyprotein Not Available 0.0069
3160 Genome polyprotein Not Available 0.0069
3260 Genome polyprotein Not Available 0.0069
4783 Genome polyprotein Not Available 0.0069
5726 Genome polyprotein Not Available 0.0069
5779 Genome polyprotein Not Available 0.0069
5867 Genome polyprotein Not Available 0.0069
6253 Genome polyprotein Not Available 0.0069
6301 Genome polyprotein Not Available 0.0069
6380 Genome polyprotein Not Available 0.0069
6381 Genome polyprotein Not Available 0.0069
6437 Genome polyprotein Not Available 0.0069
6520 Genome polyprotein Not Available 0.0069
6521 Genome polyprotein Not Available 0.0069
6652 Genome polyprotein Not Available 0.0069
6734 Genome polyprotein Not Available 0.0069
6735 Genome polyprotein Not Available 0.0069
6736 Genome polyprotein Not Available 0.0069
6737 Genome polyprotein Not Available 0.0069
6738 Genome polyprotein Not Available 0.0069
6739 Genome polyprotein Not Available 0.0069
6744 Genome polyprotein Not Available 0.0069
6748 Genome polyprotein Not Available 0.0069
6894 Genome polyprotein Not Available 0.0069
6898 Genome polyprotein Not Available 0.0069
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0067
3941 Amine oxidase [flavin-containing] A MAOA 0.0066
594 Thyroxine-binding globulin SERPINA7 0.0066
824 Sodium-dependent serotonin transporter SLC6A4 0.0065
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0064
192 Creatine kinase, ubiquitous mitochondrial CKMT1A 0.0063
456 Creatine kinase, sarcomeric mitochondrial CKMT2 0.0063
92 Creatine kinase B-type CKB 0.0063
414 Sodium- and chloride-dependent creatine transporter 1 SLC6A8 0.0063
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0063
758 Thyroid hormone receptor alpha THRA 0.0061
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.006
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.006
380 Cytochrome P450 17A1 CYP17A1 0.006
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0059
332 Beta-lactamase blaZ 0.0059
2478 Beta-lactamase ampC 0.0059
2613 Beta-lactamase ampC 0.0059
2635 Beta-lactamase ampC 0.0059
2700 Beta-lactamase penP 0.0059
5445 Beta-lactamase blaB 0.0059
6019 Beta-lactamase SHV-7 0.0059
6701 Beta-lactamase cphA 0.0059
252 Tryptophanyl-tRNA synthetase, cytoplasmic WARS 0.0059
765 Indoleamine 2,3-dioxygenase IDO1 0.0059
131 Synaptic vesicular amine transporter SLC18A2 0.0059
713 Sodium-dependent dopamine transporter SLC6A3 0.0059
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0058
6067 Penicillin binding protein 2a mecA 0.0058
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0058
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0058
532 Neutral amino acid transporter A SLC1A4 0.0057
4070 Probable alanyl-tRNA synthetase, mitochondrial AARS2 0.0057
323 Alanyl-tRNA synthetase, cytoplasmic AARS 0.0057
788 Creatine kinase M-type CKM 0.0057
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0057
2300 Lysozyme E 0.0056
3633 Lysozyme R 0.0056
5597 Lysozyme 17 0.0056
2452 Tryptophanyl-tRNA synthetase trpS 0.0056
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0056
290 Prostaglandin G/H synthase 2 PTGS2 0.0056
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0055
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0055
769 High-affinity choline transporter 1 SLC5A7 0.0055
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0055
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0055
576 Choline O-acetyltransferase CHAT 0.0055
700 Choline dehydrogenase, mitochondrial CHDH 0.0055
861 Choline kinase alpha CHKA 0.0055
3927 Choline transporter-like protein 3 SLC44A3 0.0055
1686 Choline transporter-like protein 1 SLC44A1 0.0055
3922 Phospholipase D2 PLD2 0.0055
3926 Choline transporter-like protein 2 SLC44A2 0.0055
3925 Choline transporter-like protein 4 SLC44A4 0.0055
6014 Cytochrome P450 2A13 CYP2A13 0.0055
3924 Phospholipase D1 PLD1 0.0055
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0055
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0055
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0055
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0055
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0055
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0054
346 Thyroid hormone receptor beta-1 THRB 0.0054
6012 Tryptophan 2,3-dioxygenase TDO2 0.0053
124 Histamine H2 receptor HRH2 0.0053
171 Cysteine dioxygenase CDO-1 0.0053
3426 Glutamine synthetase glnA 0.0052
3987 Glutamine synthetase GLUL 0.0052
774 Cysteinyl-tRNA synthetase, cytoplasmic CARS 0.0052
1314 Thiamine transporter 2 SLC19A3 0.0052
4064 Probable cysteinyl-tRNA synthetase, mitochondrial CARS2 0.0052
207 Glutathione synthetase GSS 0.0052
5269 Glutathione synthetase gshB 0.0052
1517 Beta-3 adrenergic receptor ADRB3 0.0052
6432 Transporter snf 0.0052
10 Glycogen phosphorylase, liver form PYGL 0.0052
860 Nicotinamide N-methyltransferase NNMT 0.0051
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0051
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0051
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0051
699 Nicotinic acid receptor 1 GPR109A 0.0051
928 Nicotinic acid receptor 2 GPR109B 0.0051
632 Alpha-1B adrenergic receptor ADRA1B 0.0051
593 Proton-coupled amino acid transporter 1 SLC36A1 0.0051
3939 Amine oxidase [flavin-containing] B MAOB 0.0051
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0051
4604 Liver carboxylesterase 1 CES1 0.0048
480 Methionine-R-sulfoxide reductase B2 MSRB2 0.0048
317 Methionine-R-sulfoxide reductase SEPX1 0.0048
3996 Betaine--homocysteine S-methyltransferase 2 BHMT2 0.0048
3921 Methionine adenosyltransferase 2 subunit beta MAT2B 0.0048
3995 Methionyl-tRNA synthetase, mitochondrial MARS2 0.0048
3811 Cytochrome P450 19A1 CYP19A1 0.0048
600 Methionyl-tRNA synthetase, cytoplasmic MARS 0.0048
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0048
1898 Cytochrome P450 1B1 CYP1B1 0.0047
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0047
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0047
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0046
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0046
163 D(1B) dopamine receptor DRD5 0.0045
751 Potassium channel subfamily K member 6 KCNK6 0.0045
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0043
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0043
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0043
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0043
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0043
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0043
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0043
1360 Sphingomyelin phosphodiesterase SMPD1 0.0043
432 D(4) dopamine receptor DRD4 0.0043
1999 Methylated-DNA--protein-cysteine methyltransferase MGMT 0.0043
6148 Multidrug resistance-associated protein 7 ABCC10 0.0042
638 D(3) dopamine receptor DRD3 0.0042
172 Potassium channel subfamily K member 1 KCNK1 0.0041
397 Monocarboxylate transporter 3 SLC16A8 0.0041
218 Monocarboxylate transporter 5 SLC16A4 0.0041
195 Monocarboxylate transporter 7 SLC16A6 0.0041
429 Monocarboxylate transporter 6 SLC16A5 0.0041
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0041
191 Peptide methionine sulfoxide reductase MSRA 0.0041
373 Transthyretin TTR 0.004
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.004
626 Cysteine dioxygenase type 1 CDO1 0.004
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0039
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0039
737 Mineralocorticoid receptor NR3C2 0.0039
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0038
1152 Glycogen phosphorylase, muscle form PYGM 0.0038
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0037
23 D(1A) dopamine receptor DRD1 0.0037
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0037
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0037
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0037
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0036
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0036
52 Pyruvate kinase isozymes R/L PKLR 0.0035
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0035
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0035
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0035
1074 Urokinase-type plasminogen activator PLAU 0.0035
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0035
831 D(2) dopamine receptor DRD2 0.0035
4085 Peptidyl-prolyl cis-trans isomerase C PPIC 0.0035
4088 Probable prolyl-tRNA synthetase, mitochondrial PARS2 0.0035
4083 Peptidyl-prolyl cis-trans isomerase H PPIH 0.0035
4087 Pyrroline 5-carboxylate reductase isoform P5CR2 0.0035
4090 Chromosome 14 open reading frame 149 C14orf149 0.0035
4082 Proline oxidase, mitochondrial PRODH 0.0035
797 Sodium-dependent proline transporter SLC6A7 0.0035
4086 Peptidyl-prolyl cis-trans isomerase G PPIG 0.0035
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0034
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0034
5 Glutaminase liver isoform, mitochondrial GLS2 0.0034
917 Glutaminase kidney isoform, mitochondrial GLS 0.0034
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0034
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0034
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0034
5261 Phosphoribosylformylglycinamidine synthase purL 0.0034
1341 Histamine H3 receptor HRH3 0.0034
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0034
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0034
771 Pyruvate carboxylase, mitochondrial PC 0.0034
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0034
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0034
840 Methionine synthase reductase, mitochondrial MTRR 0.0033
164 Histamine H4 receptor HRH4 0.0032
6031 Cytochrome P450 3A43 CYP3A43 0.0032
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0032
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0032
98 Pyruvate kinase isozymes M1/M2 PKM2 0.0032
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0031
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0031
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0031
809 Methionine synthase MTR 0.0031
2935 Methionine synthase metH 0.0031
502 5-hydroxytryptamine 2A receptor HTR2A 0.003
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.003
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.003
4084 Peptidyl-prolyl cis-trans isomerase B PPIB 0.003
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0029
1008 CTP synthase 1 CTPS 0.0029
4120 NADPH--cytochrome P450 reductase POR 0.0029
3988 Protein-glutamine gamma-glutamyltransferase K TGM1 0.0029
3985 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2 GFPT2 0.0029
3990 Protein-glutamine gamma-glutamyltransferase 4 TGM4 0.0029
3986 Protein-glutamine gamma-glutamyltransferase 6 TGM6 0.0029
3992 Protein-glutamine gamma-glutamyltransferase Z TGM7 0.0029
3983 Protein-glutamine gamma-glutamyltransferase 5 TGM5 0.0029
3989 Glutaminyl-tRNA synthetase QARS 0.0029
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0029
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0028
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0028
543 Penicillin-binding protein 1B mrcB 0.0028
6186 Penicillin-binding protein 1B ponB 0.0028
6822 Penicillin-binding protein 1b pbp1b 0.0028
6844 Penicillin-binding protein 1b pbp1b 0.0028
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0027
558 Solute carrier family 12 member 1 SLC12A1 0.0027
260 Cytochrome P450 51 ERG11 0.0027
761 Cytochrome P450 51 ERG11 0.0027
3163 Cytochrome P450 51 cyp51 0.0027
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0027
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0027
2554 Peptidyl-prolyl cis-trans isomerase, mitochondrial PPIF 0.0027
2795 Methionine aminopeptidase 2 METAP2 0.0026
4203 Histamine N-methyltransferase HNMT 0.0026
3917 Methylenetetrahydrofolate reductase MTHFR 0.0026
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.0025
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.0025
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.0025
1596 Protein-glutamine gamma-glutamyltransferase 2 TGM2 0.0024
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0024
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0024
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0024
6 Coagulation factor XIII A chain F13A1 0.0024
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0023
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0023
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0023
2164 Multidrug resistance-associated protein 4 ABCC4 0.0023
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0023
413 Amidophosphoribosyltransferase PPAT 0.0023
2515 Amidophosphoribosyltransferase purF 0.0023
3714 Amidophosphoribosyltransferase purF 0.0023
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0023
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0023
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0023
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0022
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0022
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0022
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0022
4058 Glycine N-acyltransferase-like protein 2 GLYATL2 0.0022
4057 Glycine N-acyltransferase GLYAT 0.0022
4059 Glycine N-acyltransferase-like protein 1 GLYATL1 0.0022
4056 N-arachidonyl glycine receptor GPR18 0.0022
4061 Peroxisomal sarcosine oxidase PIPOX 0.0022
4055 Bile acid CoA:amino acid N-acyltransferase BAAT 0.0022
1236 Sodium- and chloride-dependent glycine transporter 1 SLC6A9 0.0022
4062 Sodium- and chloride-dependent glycine transporter 2 SLC6A5 0.0022
4060 Vesicular inhibitory amino acid transporter SLC32A1 0.0022
1088 5-aminolevulinate synthase, erythroid-specific, mitochondrial ALAS2 0.0022
1466 Glycyl-tRNA synthetase GARS 0.0022
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0022
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0022
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0021
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0021
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0021
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.002
844 Epidermal growth factor receptor EGFR 0.002
2339 Protein-glutamine gamma-glutamyltransferase E TGM3 0.002
357 Carbonic anhydrase 2 CA2 0.0019
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0019
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0019
84 Nuclear receptor 0B1 NR0B1 0.0019
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0019
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0018
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0018
756 Sex hormone-binding globulin SHBG 0.0018
153 Dopamine beta-hydroxylase DBH 0.0018
4054 Glycine cleavage system H protein, mitochondrial GCSH 0.0017
469 Annexin A1 ANXA1 0.0017
6218 Pannexin-1 PANX1 0.0017
1039 Histone deacetylase 9 HDAC9 0.0017
62 Glycine receptor subunit beta GLRB 0.0017
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0016
411 Glycine N-methyltransferase GNMT 0.0016
4998 Hemoglobin-like protein yjbI yjbI 0.0015
4934 Cytochrome c-551 nirM 0.0015
5218 Cytochrome c-551 nirM 0.0015
4905 Cytochrome c2 Not Available 0.0015
4939 Cytochrome c2 cycA 0.0015
4964 Cytochrome c2 cycA 0.0015
4979 Cytochrome c2 cycA 0.0015
6673 Cytochrome c2 cycA 0.0015
4943 Cytochrome c6 petJ 0.0015
4954 Soluble cytochrome b558 Not Available 0.0015
4936 Cytochrome c2 iso-2 Not Available 0.0015
4916 Cyanoglobin glbN 0.0015
4994 Hemoglobin-like protein HbO glbO 0.0015
4915 Cytochrome c-550 psbV 0.0015
4959 Cytochrome c-550 psbV 0.0015
5216 Cytochrome c-550 psbV 0.0015
4925 Cytochrome c-type protein SHP shp 0.0015
4947 Bacterial hemoglobin vhb 0.0015
4942 Diheme cytochrome c napB napB 0.0015
4984 Neuroglobin NGB 0.0015
4981 Iron-starvation protein PigA pigA 0.0015
3116 Bacterioferritin bfr 0.0015
4906 Bacterioferritin bfr 0.0015
4965 Bacterioferritin bfr 0.0015
4909 CooA protein cooA 0.0015
5000 HemO hemO 0.0015
4961 Hemophore HasA hasA 0.0015
4910 Cytoglobin CYGB 0.0015
4975 Cytochrome c-556 RPA3973 0.0015
4907 Cytochrome c-L moxG 0.0015
6865 Cytochrome c-L moxG 0.0015
4935 Cytochrome c-554 cycA1 0.0015
644 Heme oxygenase 2 HMOX2 0.0015
4982 Heme oxygenase 2 pbsA2 0.0015
4764 Cytochrome P450 165C4 CYP165C4 0.0015
4972 P450cin cinA 0.0015
4937 Cytochrome oxidase subunit II rcoxA 0.0015
4971 Nonaheme cytochrome c hmcA 0.0015
4960 Putative cytochrome P450-family protein SCO7417 0.0015
4989 Cytochrome c551 peroxidase ccp 0.0015
5222 Cytochrome c551 peroxidase ccpA 0.0015
4976 Apocytochrome f petA 0.0015
6407 Apocytochrome f petA 0.0015
4904 Cytochrome c family protein GSU1996 0.0015
4922 Cytochrome c, putative SO_4144 0.0015
4931 Cytochrome P450 167A1 CYP167A1 0.0015
4952 Catalase/peroxidase katA 0.0015
4999 Cytochrome P450 165B3 CYP165B3 0.0015
4926 Heme-based aerotactic transducer hemAT hemAT 0.0015
4993 Hydroxylamine oxidoreductase hao1 0.0015
3093 Catalase HPII katE 0.0015
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0015
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0015
4903 Methyl-accepting chemotaxis protein Tar4 0.0015
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0015
146 Androgen receptor AR 0.0015
3810 Catechol O-methyltransferase COMT 0.0014
468 Cytochrome P450 4A11 CYP4A11 0.0014
6149 Solute carrier family 22 member 10 SLC22A10 0.0014
820 Glycine receptor subunit alpha-2 GLRA2 0.0014
461 Glycine receptor subunit alpha-3 GLRA3 0.0014
4037 Hypothetical protein GPX1 0.0013
4297 Hypothetical protein SP_1951 0.0013
4521 Hypothetical protein BC_2969 0.0013
4540 Hypothetical protein TM_1070 0.0013
4555 Hypothetical protein MT1739 0.0013
4569 Hypothetical protein mshD 0.0013
4578 Hypothetical protein PA3270 0.0013
4747 Hypothetical protein PA3967 0.0013
5177 Hypothetical protein TM_0096 0.0013
5194 Hypothetical protein PA1204 0.0013
5240 Hypothetical protein Rv2991 0.0013
5370 Hypothetical protein TM_1158 0.0013
5710 Hypothetical protein Tb927.5.1360 0.0013
4990 PpcA ppcA 0.0013
4385 Cytochrome c' Not Available 0.0013
4967 Cytochrome c' cycA 0.0013
5038 Cytochrome c' Not Available 0.0013
5223 Cytochrome c' cycP 0.0013
3570 Cytochrome P450 152A1 cypC 0.0013
4289 Cytochrome P450 TT_P0059 0.0013
6262 Cytochrome P450 staP 0.0013
4920 Peroxidase/catalase katG 0.0013
4948 Cytochrome c-553 Not Available 0.0013
4992 Cytochrome c peroxidase Not Available 0.0013
4923 Cytochrome c3 DvMF_2499 0.0013
4945 Cytochrome c3 Not Available 0.0013
4949 Cytochrome c3 DVU_3171 0.0013
4968 Cytochrome c3 cytc3 0.0013
4997 Cytochrome c3 SO_2727 0.0013
5219 Cytochrome c3 cyd 0.0013
4902 Nine-heme cytochrome c Ddes_2038 0.0013
2119 Cytochrome b5 CYB5A 0.0013
4813 Heme oxygenase hmuO 0.0013
5769 Heme oxygenase Not Available 0.0013
4988 Sulfite oxidase, mitochondrial SUOX 0.0013
3189 High-molecular-weight cytochrome c hmcA 0.0013
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0013
3375 Acidic cytochrome c3 Not Available 0.0013
2915 Sensor protein fixL fixL 0.0013
4944 Sensor protein fixL fixL 0.0013
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0013
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0012
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0012
4386 Hemoglobin-like protein HbN glbN 0.0012
3670 Soluble cytochrome b562 precursor cybC 0.0012
3291 Cytochrome c-552 cycA 0.0012
4927 Cytochrome c-552 nrfA 0.0012
4938 Cytochrome c-552 cycA 0.0012
4953 Cytochrome c-552 nrfA 0.0012
5217 Cytochrome c-552 cycM 0.0012
3102 Flavohemoprotein hmp 0.0012
4969 Flavohemoprotein hmp 0.0012
3411 Cytochrome P450 121 cyp121 0.0012
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0011
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0011
3127 Nitrite reductase nirS 0.0011
3284 Nitrite reductase nirS 0.0011
3221 Cytochrome c4 cc4 0.0011
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0011
2230 Catalase CAT 0.0011
3249 Catalase katA 0.0011
3625 Catalase katA 0.0011
4539 Catalase katA 0.0011
4941 Catalase katB 0.0011
871 Glucocorticoid receptor NR3C1 0.0011
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0011
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0011
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0011
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0011
664 Glutamate decarboxylase 2 GAD2 0.0011
3890 Glutamate decarboxylase 2 GAD2 0.0011
4026 Aspartyl aminopeptidase DNPEP 0.0011
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0011
1912 Excitatory amino acid transporter 1 SLC1A3 0.0011
4016 Excitatory amino acid transporter 5 SLC1A7 0.0011
4019 Excitatory amino acid transporter 4 SLC1A6 0.0011
4017 5-oxoprolinase OPLAH 0.0011
1047 Excitatory amino acid transporter 2 SLC1A2 0.0011
926 Metabotropic glutamate receptor 7 GRM7 0.0011
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0011
4018 Glutamate receptor delta-2 subunit GRID2 0.0011
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0011
922 Glutamate receptor 4 GRIA4 0.0011
927 Metabotropic glutamate receptor 8 GRM8 0.0011
925 Metabotropic glutamate receptor 4 GRM4 0.0011
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0011
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0011
4020 Glutamyl aminopeptidase ENPEP 0.0011
4027 Glutamate receptor delta-1 subunit GRID1 0.0011
605 Fumarate reductase flavoprotein subunit frdA 0.001
2709 Fumarate reductase flavoprotein subunit SO_0970 0.001
3673 Fumarate reductase flavoprotein subunit fccA 0.001
4912 Fumarate reductase flavoprotein subunit ifcA 0.001
6549 Fumarate reductase flavoprotein subunit frdA 0.001
2972 6-deoxyerythronolide B hydroxylase eryF 0.001
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0009
6136 Multidrug resistance-associated protein 5 ABCC5 0.0009
1507 Cytochrome c CYCS 0.0009
518 Peroxidase/catalase T katG 0.0009
693 Hemoglobin subunit beta HBB 0.0009
6268 Hydroxyacid oxidase 1 HAO1 0.0009
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0009
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0009
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0009
625 Glutamate carboxypeptidase 2 FOLH1 0.0009
810 Heme oxygenase 1 HMOX1 0.0009
3391 Heme oxygenase 1 pbsA1 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
916 Metabotropic glutamate receptor 1 GRM1 0.0008
2298 Cytochrome P450-cam camC 0.0008
923 Glutamate receptor 3 GRIA3 0.0008
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0008
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0008
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0008
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0007
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0007
705 Glutamate receptor 1 GRIA1 0.0006
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0006
275 Arachidonate 5-lipoxygenase ALOX5 0.0006
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0005
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0005
921 Glutamate receptor 2 GRIA2 0.0005
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