DT-Web: DB00119

Identification
Name	Pyruvic acid
Accession Number	DB00119 (NUTR00050)
Type	small molecule
Description	An intermediate compound in the metabolism of carbohydrates, proteins, and fats. In thiamine deficiency, its oxidation is retarded and it accumulates in the tissues, especially in nervous structures. (From Stedman, 26th ed)
Structure	MOL SDF PDB SMILES InChI
Categories ^(*)	Dietary supplement Micronutrient
Molecular Weight	88.0621
Groups	approved
Monoisotopic Weight	88.016043994
Pharmacology
Indication	For nutritional supplementation, also for treating dietary shortage or imbalance
Mechanism of action	Pyruvate serves as a biological fuel by being converted to acetyl coenzyme A, which enters the tricarboxylic acid or Krebs cycle where it is metabolized to produce ATP aerobically. Energy can also be obtained anaerobically from pyruvate via its conversion to lactate. Pyruvate injections or perfusions increase contractile function of hearts when metabolizing glucose or fatty acids. This inotropic effect is striking in hearts stunned by ischemia/reperfusion. The inotropic effect of pyruvate requires intracoronary infusion. Among possible mechanisms for this effect are increased generation of ATP and an increase in ATP phosphorylation potential. Another is activation of pyruvate dehydrogenase, promoting its own oxidation by inhibiting pyruvate dehydrogenase kinase. Pyruvate dehydrogenase is inactivated in ischemia myocardium. Yet another is reduction of cytosolic inorganic phosphate concentration. Pyruvate, as an antioxidant, is known to scavenge such reactive oxygen species as hydrogen peroxide and lipid peroxides. Indirectly, supraphysiological levels of pyruvate may increase cellular reduced glutathione.
Absorption	Pyruvate is absorbed from the gastrointestinal tract from whence it is transported to the liver via the portal circulation.
Protein binding	Not Available
Biotransformation	In the liver, pyruvate is metabolized via several pathways.
Route of elimination	Not Available
Toxicity	Those taking large doses of supplemental pyruvate—usually greater than 5 grams daily—have reported gastrointestinal symptoms, including abdominal discomfort and bloating, gas and diarrhea. One child receiving pyruvate intravenously for restrictive cardiomyopathy died.
Affected organisms	Humans and other mammals
Interactions
Drug Interactions	Not Available
Food Interactions	Not Available

Monocarboxylate transporter 4
Name	Monocarboxylate transporter 4
Gene Name	SLC16A3
Pharmacological action	unknown
Actions	Not Available
References	Shimada A, Nakagawa Y, Morishige H, Yamamoto A, Fujita T: Functional characteristics of H+ -dependent nicotinate transport in primary cultures of astrocytes from rat cerebral cortex. Neurosci Lett. 2006 Jan 16;392(3):207-12. Epub 2005 Oct 5. - Pubmed
DTHybrid score	0.8934
Monocarboxylate transporter 8
Name	Monocarboxylate transporter 8
Gene Name	SLC16A2
Pharmacological action	unknown
Actions	Not Available
References	Bonen A, Heynen M, Hatta H: Distribution of monocarboxylate transporters MCT1-MCT8 in rat tissues and human skeletal muscle. Appl Physiol Nutr Metab. 2006 Feb;31(1):31-9. - Pubmed
DTHybrid score	0.5114
Alanine--glyoxylate aminotransferase 2, mitochondrial
Name	Alanine--glyoxylate aminotransferase 2, mitochondrial
Gene Name	AGXT2
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Tamaki N, Fujimoto S, Mizota C, Kaneko M, Kikugawa M: Inhibitory effect of 6-azauracil on beta-alanine metabolism in rat. J Nutr Sci Vitaminol (Tokyo). 1989 Oct;35(5):451-61. - Pubmed
DTHybrid score	0.4725
Monocarboxylate transporter 6
Name	Monocarboxylate transporter 6
Gene Name	SLC16A5
Pharmacological action	unknown
Actions	Not Available
References	Bonen A, Heynen M, Hatta H: Distribution of monocarboxylate transporters MCT1-MCT8 in rat tissues and human skeletal muscle. Appl Physiol Nutr Metab. 2006 Feb;31(1):31-9. - Pubmed
DTHybrid score	0.6757
Pyruvate kinase isozymes R/L
Name	Pyruvate kinase isozymes R/L
Gene Name	PKLR
Pharmacological action	unknown
Actions	Not Available
References	Percy MJ, van Wijk R, Haggan S, Savage GA, Boyd K, Dempsey S, Hamilton J, Kettle P, Kyle A, Shepherd CW, van Solinge WW, Lappin TR, McMullin MF: Pyruvate kinase deficient hemolytic anemia in the Northern Irish population. Blood Cells Mol Dis. 2007 Sep-Oct;39(2):189-94. Epub 2007 Jun 15. - Pubmed Meza NW, Quintana-Bustamante O, Puyet A, Rio P, Navarro S, Diez A, Bueren JA, Bautista JM, Segovia JC: In vitro and in vivo expression of human erythrocyte pyruvate kinase in erythroid cells: a gene therapy approach. Hum Gene Ther. 2007 Jun;18(6):502-14. - Pubmed Rajaseger G, Lim CL, Lee KW, Arjunan P, Jia L, Moochhala S: Profiling of hepatocellular proteins by 1D PAGE-MALDI/MS/MS in a rat heat stress model. Front Biosci. 2006 Sep 1;11:2924-8. - Pubmed Xu J, Christian B, Jump DB: Regulation of rat hepatic L-pyruvate kinase promoter composition and activity by glucose, n-3 polyunsaturated fatty acids, and peroxisome proliferator-activated receptor-alpha agonist. J Biol Chem. 2006 Jul 7;281(27):18351-62. Epub 2006 Apr 27. - Pubmed Suzuki T, Kawamoto M, Murai A, Muramatsu T: Identification of the regulatory region of the L-type pyruvate kinase gene in mouse liver by hydrodynamics-based gene transfection. J Nutr. 2006 Jan;136(1):16-20. - Pubmed
DTHybrid score	0.7662
Monocarboxylate transporter 7
Name	Monocarboxylate transporter 7
Gene Name	SLC16A6
Pharmacological action	unknown
Actions	Not Available
References	Bonen A, Heynen M, Hatta H: Distribution of monocarboxylate transporters MCT1-MCT8 in rat tissues and human skeletal muscle. Appl Physiol Nutr Metab. 2006 Feb;31(1):31-9. - Pubmed
DTHybrid score	0.6757
Monocarboxylate transporter 2
Name	Monocarboxylate transporter 2
Gene Name	SLC16A7
Pharmacological action	unknown
Actions	Not Available
References	Bonen A, Heynen M, Hatta H: Distribution of monocarboxylate transporters MCT1-MCT8 in rat tissues and human skeletal muscle. Appl Physiol Nutr Metab. 2006 Feb;31(1):31-9. - Pubmed Hinoi E, Takarada T, Tsuchihashi Y, Fujimori S, Moriguchi N, Wang L, Uno K, Yoneda Y: A molecular mechanism of pyruvate protection against cytotoxicity of reactive oxygen species in osteoblasts. Mol Pharmacol. 2006 Sep;70(3):925-35. Epub 2006 Jun 9. - Pubmed Yoshida Y, Holloway GP, Ljubicic V, Hatta H, Spriet LL, Hood DA, Bonen A: Negligible direct lactate oxidation in subsarcolemmal and intermyofibrillar mitochondria obtained from red and white rat skeletal muscle. J Physiol. 2007 Aug 1;582(Pt 3):1317-35. Epub 2007 Jun 7. - Pubmed de Laplanche E, Gouget K, Cleris G, Dragounoff F, Demont J, Morales A, Bezin L, Godinot C, Perriere G, Mouchiroud D, Simonnet H: Physiological oxygenation status is required for fully differentiated phenotype in kidney cortex proximal tubules. Am J Physiol Renal Physiol. 2006 Oct;291(4):F750-60. Epub 2006 Apr 4. - Pubmed Pierre K, Pellerin L: Monocarboxylate transporters in the central nervous system: distribution, regulation and function. J Neurochem. 2005 Jul;94(1):1-14. - Pubmed
DTHybrid score	0.884
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Name	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial
Gene Name	PDHB
Pharmacological action	unknown
Actions	Not Available
References	Kumar V, Rangaraj N, Shivaji S: Activity of pyruvate dehydrogenase A (PDHA) in hamster spermatozoa correlates positively with hyperactivation and is associated with sperm capacitation. Biol Reprod. 2006 Nov;75(5):767-77. Epub 2006 Jul 19. - Pubmed
DTHybrid score	0.5
Pyruvate kinase isozymes M1/M2
Name	Pyruvate kinase isozymes M1/M2
Gene Name	PKM2
Pharmacological action	unknown
Actions	Not Available
References	Li Y, Chang Y, Zhang L, Feng Q, Liu Z, Zhang Y, Zuo J, Meng Y, Fang F: High glucose upregulates pantothenate kinase 4 (PanK4) and thus affects M2-type pyruvate kinase (Pkm2). Mol Cell Biochem. 2005 Sep;277(1-2):117-25. - Pubmed Stetak A, Veress R, Ovadi J, Csermely P, Keri G, Ullrich A: Nuclear translocation of the tumor marker pyruvate kinase M2 induces programmed cell death. Cancer Res. 2007 Feb 15;67(4):1602-8. - Pubmed Vlaeminck-Guillem V, Safi R, Guillem P, Leteurtre E, Duterque-Coquillaud M, Laudet V: Thyroid hormone receptor expression in the obligatory paedomorphic salamander Necturus maculosus. Int J Dev Biol. 2006;50(6):553-60. - Pubmed Weinberger R, Appel B, Stein A, Metz Y, Neheman A, Barak M: The pyruvate kinase isoenzyme M2 (Tu M2-PK) as a tumour marker for renal cell carcinoma. Eur J Cancer Care (Engl). 2007 Jul;16(4):333-7. - Pubmed Staib P, Hoffmann M, Schinkothe T: Plasma levels of tumor M2-pyruvate kinase should not be used as a tumor marker for hematological malignancies and solid tumors. Clin Chem Lab Med. 2006;44(1):28-31. - Pubmed
DTHybrid score	1.6526
4-aminobutyrate aminotransferase, mitochondrial
Name	4-aminobutyrate aminotransferase, mitochondrial
Gene Name	ABAT
Pharmacological action	unknown
Actions	inhibitor
References	Andersen G, Andersen B, Dobritzsch D, Schnackerz KD, Piskur J: A gene duplication led to specialized gamma-aminobutyrate and beta-alanine aminotransferase in yeast. FEBS J. 2007 Apr;274(7):1804-17. Epub 2007 Mar 12. - Pubmed Schmidt C, Hofmann U, Kohlmuller D, Murdter T, Zanger UM, Schwab M, Hoffmann GF: Comprehensive analysis of pyrimidine metabolism in 450 children with unspecific neurological symptoms using high-pressure liquid chromatography-electrospray ionization tandem mass spectrometry. J Inherit Metab Dis. 2005;28(6):1109-22. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.7881
Monocarboxylate transporter 5
Name	Monocarboxylate transporter 5
Gene Name	SLC16A4
Pharmacological action	unknown
Actions	Not Available
References	Kay HH, Zhu S, Tsoi S: Hypoxia and lactate production in trophoblast cells. Placenta. 2007 Aug-Sep;28(8-9):854-60. Epub 2007 Feb 2. - Pubmed Han M, Trotta P, Coleman C, Linask KK: MCT-4, A511/Basigin and EF5 expression patterns during early chick cardiomyogenesis indicate cardiac cell differentiation occurs in a hypoxic environment. Dev Dyn. 2006 Jan;235(1):124-31. - Pubmed Bonen A, Heynen M, Hatta H: Distribution of monocarboxylate transporters MCT1-MCT8 in rat tissues and human skeletal muscle. Appl Physiol Nutr Metab. 2006 Feb;31(1):31-9. - Pubmed Pierre K, Pellerin L: Monocarboxylate transporters in the central nervous system: distribution, regulation and function. J Neurochem. 2005 Jul;94(1):1-14. - Pubmed Shimada A, Nakagawa Y, Morishige H, Yamamoto A, Fujita T: Functional characteristics of H+ -dependent nicotinate transport in primary cultures of astrocytes from rat cerebral cortex. Neurosci Lett. 2006 Jan 16;392(3):207-12. Epub 2005 Oct 5. - Pubmed
DTHybrid score	0.6755
Monocarboxylate transporter 3
Name	Monocarboxylate transporter 3
Gene Name	SLC16A8
Pharmacological action	unknown
Actions	Not Available
References	Jansen S, Esmaeilpour T, Pantaleon M, Kaye PL: Glucose affects monocarboxylate cotransporter (MCT) 1 expression during mouse preimplantation development. Reproduction. 2006 Mar;131(3):469-79. - Pubmed
DTHybrid score	0.6762
Monocarboxylate transporter 1
Name	Monocarboxylate transporter 1
Gene Name	SLC16A1
Pharmacological action	unknown
Actions	Not Available
References	Duerr JM, Tucker K: Pyruvate transport in isolated cardiac mitochondria from two species of amphibian exhibiting dissimilar aerobic scope: Bufo marinus and Rana catesbeiana. J Exp Zool Part A Ecol Genet Physiol. 2007 Aug 1;307(8):425-38. - Pubmed Han M, Trotta P, Coleman C, Linask KK: MCT-4, A511/Basigin and EF5 expression patterns during early chick cardiomyogenesis indicate cardiac cell differentiation occurs in a hypoxic environment. Dev Dyn. 2006 Jan;235(1):124-31. - Pubmed Shimoyama Y, Akihara Y, Kirat D, Iwano H, Hirayama K, Kagawa Y, Ohmachi T, Matsuda K, Okamoto M, Kadosawa T, Yokota H, Taniyama H: Expression of monocarboxylate transporter 1 in oral and ocular canine melanocytic tumors. Vet Pathol. 2007 Jul;44(4):449-57. - Pubmed Shimada A, Nakagawa Y, Morishige H, Yamamoto A, Fujita T: Functional characteristics of H+ -dependent nicotinate transport in primary cultures of astrocytes from rat cerebral cortex. Neurosci Lett. 2006 Jan 16;392(3):207-12. Epub 2005 Oct 5. - Pubmed Philp A, Macdonald AL, Watt PW: Lactate--a signal coordinating cell and systemic function. J Exp Biol. 2005 Dec;208(Pt 24):4561-75. - Pubmed
DTHybrid score	0.797
Pyruvate carboxylase, mitochondrial
Name	Pyruvate carboxylase, mitochondrial
Gene Name	PC
Pharmacological action	unknown
Actions	Not Available
References	Jitrapakdee S, Vidal-Puig A, Wallace JC: Anaplerotic roles of pyruvate carboxylase in mammalian tissues. Cell Mol Life Sci. 2006 Apr;63(7-8):843-54. - Pubmed Simpson NE, Khokhlova N, Oca-Cossio JA, Constantinidis I: Insights into the role of anaplerosis in insulin secretion: A 13C NMR study. Diabetologia. 2006 Jun;49(6):1338-48. Epub 2006 Mar 31. - Pubmed Jensen MV, Joseph JW, Ilkayeva O, Burgess S, Lu D, Ronnebaum SM, Odegaard M, Becker TC, Sherry AD, Newgard CB: Compensatory responses to pyruvate carboxylase suppression in islet beta-cells. Preservation of glucose-stimulated insulin secretion. J Biol Chem. 2006 Aug 4;281(31):22342-51. Epub 2006 Jun 1. - Pubmed Ikeda K, Yukihiro Hiraoka B, Iwai H, Matsumoto T, Mineki R, Taka H, Takamori K, Ogawa H, Yamakura F: Detection of 6-nitrotryptophan in proteins by Western blot analysis and its application for peroxynitrite-treated PC12 cells. Nitric Oxide. 2007 Feb;16(1):18-28. Epub 2006 May 4. - Pubmed Liu L, Li Y, Zhu Y, Du G, Chen J: Redistribution of carbon flux in Torulopsis glabrata by altering vitamin and calcium level. Metab Eng. 2007 Jan;9(1):21-9. Epub 2006 Aug 12. - Pubmed
DTHybrid score	0.6796

Monocarboxylate transporter 2
Name	Monocarboxylate transporter 2
Gene Name	SLC16A7
Actions	substrate,inhibitor
References	Broer S, Broer A, Schneider HP, Stegen C, Halestrap AP, Deitmer JW: Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes. Biochem J. 1999 Aug 1;341 ( Pt 3):529-35. - Pubmed Lin RY, Vera JC, Chaganti RS, Golde DW: Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter. J Biol Chem. 1998 Oct 30;273(44):28959-65. - Pubmed
DTHybrid score	0.884
Monocarboxylate transporter 1
Name	Monocarboxylate transporter 1
Gene Name	SLC16A1
Actions	substrate,inhibitor
References	Broer S, Rahman B, Pellegri G, Pellerin L, Martin JL, Verleysdonk S, Hamprecht B, Magistretti PJ: Comparison of lactate transport in astroglial cells and monocarboxylate transporter 1 (MCT 1) expressing Xenopus laevis oocytes. Expression of two different monocarboxylate transporters in astroglial cells and neurons. J Biol Chem. 1997 Nov 28;272(48):30096-102. - Pubmed Broer S, Schneider HP, Broer A, Rahman B, Hamprecht B, Deitmer JW: Characterization of the monocarboxylate transporter 1 expressed in Xenopus laevis oocytes by changes in cytosolic pH. Biochem J. 1998 Jul 1;333 ( Pt 1):167-74. - Pubmed Lin RY, Vera JC, Chaganti RS, Golde DW: Human monocarboxylate transporter 2 (MCT2) is a high affinity pyruvate transporter. J Biol Chem. 1998 Oct 30;273(44):28959-65. - Pubmed
DTHybrid score	0.797
Monocarboxylate transporter 10
Name	Monocarboxylate transporter 10
Gene Name	SLC16A10
Actions	substrate,inhibitor
References	Kim DK, Kanai Y, Chairoungdua A, Matsuo H, Cha SH, Endou H: Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. J Biol Chem. 2001 May 18;276(20):17221-8. Epub 2001 Feb 20. - Pubmed Kim DK, Kanai Y, Matsuo H, Kim JY, Chairoungdua A, Kobayashi Y, Enomoto A, Cha SH, Goya T, Endou H: The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location. Genomics. 2002 Jan;79(1):95-103. - Pubmed
DTHybrid score	0.6813
Solute carrier organic anion transporter family member 2A1
Name	Solute carrier organic anion transporter family member 2A1
Gene Name	SLCO2A1
Actions	inhibitor
References	Chan BS, Endo S, Kanai N, Schuster VL: Identification of lactate as a driving force for prostanoid transport by prostaglandin transporter PGT. Am J Physiol Renal Physiol. 2002 Jun;282(6):F1097-102. - Pubmed
DTHybrid score	0.6616
Monocarboxylate transporter 4
Name	Monocarboxylate transporter 4
Gene Name	SLC16A3
Actions	substrate
References	Manning Fox JE, Meredith D, Halestrap AP: Characterisation of human monocarboxylate transporter 4 substantiates its role in lactic acid efflux from skeletal muscle. J Physiol. 2000 Dec 1;529 Pt 2:285-93. - Pubmed
DTHybrid score	0.8934

Id	Partner name	Gene Name	Score
2922	Glycerol kinase	glpK	0.2223
6468	Pyruvate carboxylase	pycA	0.1954
6467	Acyl-CoA carboxylase	yngHB	0.1952
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.121
5650	NimA-related protein	DR_0842	0.1058
3676	Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive	aroG	0.1015
795	Branched-chain-amino-acid aminotransferase, mitochondrial	BCAT2	0.094
2904	Phosphatase yniC	yniC	0.092
593	Proton-coupled amino acid transporter 1	SLC36A1	0.0907
3184	3-methyl-2-oxobutanoate hydroxymethyltransferase	panB	0.0843
3315	3-methyl-2-oxobutanoate hydroxymethyltransferase	panB	0.0843
3179	2-isopropylmalate synthase	leuA	0.0843
3254	Bifunctional protein putA [Includes: Proline dehydrogenase	putA	0.0836
3192	Glucosamine-6-phosphate deaminase 1	nagB	0.0796
3309	6-phosphofructokinase	pfkA	0.0791
3467	Methylglyoxal synthase	mgsA	0.0782
3334	Deacetoxycephalosporin C synthetase	cefE	0.067
399	Tyrosyl-tRNA synthetase, mitochondrial	YARS2	0.0654
2314	Triosephosphate isomerase	TPI	0.0645
3417	Triosephosphate isomerase	tpiA	0.0645
3443	Triosephosphate isomerase	tpiA	0.0645
6346	Triosephosphate isomerase	TPI1	0.0645
763	Tyrosine aminotransferase	TAT	0.0631
5493	Tyrosine aminotransferase	Not Available	0.0631
601	Propionyl-CoA carboxylase beta chain, mitochondrial	PCCB	0.0615
547	Propionyl-CoA carboxylase alpha chain, mitochondrial	PCCA	0.0595
495	Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial	MCCC1	0.0595
690	Acetyl-CoA carboxylase 1	ACACA	0.0594
81	Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial	MCCC2	0.0594
177	Biotin--protein ligase	HLCS	0.0594
574	Branched-chain-amino-acid aminotransferase, cytosolic	BCAT1	0.0579
735	Alanine aminotransferase 1	GPT	0.0575
3904	Alanine aminotransferase 2	GPT2	0.0574
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0571
2293	Cyclomaltodextrin glucanotransferase	Not Available	0.0568
2508	Cyclomaltodextrin glucanotransferase	cgt	0.0568
2523	Cyclomaltodextrin glucanotransferase	cgt	0.0568
3207	Cyclomaltodextrin glucanotransferase	amyA	0.0568
349	Serine--pyruvate aminotransferase	AGXT	0.0554
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.054
532	Neutral amino acid transporter A	SLC1A4	0.0533
4070	Probable alanyl-tRNA synthetase, mitochondrial	AARS2	0.0533
323	Alanyl-tRNA synthetase, cytoplasmic	AARS	0.0533
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0525
169	Cysteine desulfurase, mitochondrial	NFS1	0.0511
3899	Alanine--glyoxylate aminotransferase 2-like 2	AGXT2L2	0.0506
866	Large neutral amino acids transporter small subunit 2	SLC7A8	0.0503
676	Tyrosine 3-monooxygenase	TH	0.0488
105	Sodium-dependent multivitamin transporter	SLC5A6	0.0484
501	Leucine carboxyl methyltransferase 1	LCMT1	0.0467
675	Leucine carboxyl methyltransferase 2	LCMT2	0.0466
846	Leucyl-tRNA synthetase, cytoplasmic	LARS	0.0466
227	Probable leucyl-tRNA synthetase, mitochondrial	LARS2	0.0466
3205	Isocitrate lyase	icl	0.0466
3078	Regulator of ribonuclease activity A	Rv3853	0.0466
435	Kynureninase	KYNU	0.0461
4654	Kynureninase	kynU	0.0461
6142	Solute carrier family 22 member 8	SLC22A8	0.0461
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0454
4132	Chloride channel protein ClC-Ka	CLCNKA	0.044
256	Tyrosyl-tRNA synthetase, cytoplasmic	YARS	0.0425
587	Serum albumin	ALB	0.0424
1729	Solute carrier family 22 member 6	SLC22A6	0.0421
1566	Corticoliberin	CRH	0.0413
2597	Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	glmS	0.0403
118	Organic cation/carnitine transporter 2	SLC22A5	0.0385
4063	Tryptophanyl-tRNA synthetase, mitochondrial	WARS2	0.0382
90	Tryptophan 5-hydroxylase 2	TPH2	0.0382
2206	Glucose-6-phosphate isomerase	GPI	0.0381
3736	Glyceraldehyde-3-phosphate dehydrogenase A	gapA	0.0376
775	Acetyl-CoA carboxylase 2	ACACB	0.0375
4628	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase	gapN	0.0375
594	Thyroxine-binding globulin	SERPINA7	0.0365
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0362
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0351
2248	Malate synthase G	glcB	0.0335
3190	Malate synthase G	glcB	0.0335
6826	Bacilysin biosynthesis protein bacB	bacB	0.0328
6827	Probable chorismate mutase	pheA	0.0327
6508	Putative uncharacterized protein	srtB	0.0327
6543	Putative uncharacterized protein	tcp14	0.0327
6615	Putative uncharacterized protein	MT0785	0.0327
6623	Putative uncharacterized protein	Not Available	0.0327
6806	Putative uncharacterized protein	AGR_C_2535	0.0327
6813	Putative uncharacterized protein	SAV4671	0.0327
6815	Putative uncharacterized protein	AFE_1514	0.0327
6819	Putative uncharacterized protein	RUMGNA_03254	0.0327
6825	Putative uncharacterized protein	CV_3270	0.0327
758	Thyroid hormone receptor alpha	THRA	0.0327
4924	Cytochrome P450 2C8	CYP2C8	0.0324
1024	Solute carrier family 22 member 11	SLC22A11	0.0323
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0319
20	Prostaglandin G/H synthase 1	PTGS1	0.0319
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0318
765	Indoleamine 2,3-dioxygenase	IDO1	0.0313
2424	L-lactate dehydrogenase	ldh	0.03
2641	L-lactate dehydrogenase	Not Available	0.03
4437	L-lactate dehydrogenase	ldh	0.03
4442	L-lactate dehydrogenase	ldh	0.03
126	D-lactate dehydrogenase	dld	0.03
3545	D-lactate dehydrogenase	Not Available	0.03
4510	D-lactate dehydrogenase	ldhA	0.03
6143	Solute carrier family 22 member 7	SLC22A7	0.0299
860	Nicotinamide N-methyltransferase	NNMT	0.0298
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0298
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0298
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0298
928	Nicotinic acid receptor 2	GPR109B	0.0297
699	Nicotinic acid receptor 1	GPR109A	0.0297
1588	Multidrug resistance protein 1	ABCB1	0.0296
252	Tryptophanyl-tRNA synthetase, cytoplasmic	WARS	0.0289
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0288
6645	D-amino-acid oxidase	DAO	0.0286
2532	Pantoate--beta-alanine ligase	panC	0.0285
5607	Indole-3-pyruvate decarboxylase	ipdC	0.0284
6657	Indole-3-pyruvate decarboxylase	ipdC	0.0284
6616	L-phenylalanine dehydrogenase	pdh	0.0284
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0283
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.028
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0276
77	L-lactate dehydrogenase B chain	LDHB	0.0272
6500	Phospholipase A2	PLA2G1B	0.027
134	Tryptophan 5-hydroxylase 1	TPH1	0.027
2452	Tryptophanyl-tRNA synthetase	trpS	0.0269
346	Thyroid hormone receptor beta-1	THRB	0.0267
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0265
473	L-lactate dehydrogenase A chain	LDHA	0.0261
3178	Formate acetyltransferase 1	pflB	0.026
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0259
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0251
1898	Cytochrome P450 1B1	CYP1B1	0.0245
527	Prostacyclin receptor	PTGIR	0.0233
5925	Neuropeptide Y	NPY	0.0231
314	System N amino acid transporter 1	SLC38A3	0.0229
723	Cytosolic phospholipase A2	PLA2G4A	0.0229
2164	Multidrug resistance-associated protein 4	ABCC4	0.0227
534	Threonine synthase-like 1	THNSL1	0.0224
2853	14 kDa fatty acid-binding protein	Not Available	0.0219
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0218
3134	Phospho-2-dehydro-3-deoxyheptonate aldolase	aroF	0.0215
6141	Sodium/bile acid cotransporter	SLC10A1	0.0215
301	Kynurenine--oxoglutarate transaminase 1	CCBL1	0.0206
6268	Hydroxyacid oxidase 1	HAO1	0.0206
6136	Multidrug resistance-associated protein 5	ABCC5	0.0203
4757	Cytochrome P450 2C9	CYP2C9	0.0202
4384	Capsule biosynthesis protein	synC	0.0199
4069	Threonyl-tRNA synthetase, mitochondrial	TARS2	0.0197
261	Threonyl-tRNA synthetase, cytoplasmic	TARS	0.0197
455	5-aminolevulinate synthase, nonspecific, mitochondrial	ALAS1	0.0196
575	2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial	GCAT	0.0196
681	Glycine dehydrogenase [decarboxylating], mitochondrial	GLDC	0.0196
246	Valyl-tRNA synthetase	VARS	0.0196
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0194
373	Transthyretin	TTR	0.0192
3	Histidine decarboxylase	HDC	0.0188
1116	Phosphoenolpyruvate carboxykinase, cytosolic [GTP]	PCK1	0.0188
3913	Glutamic acid decarboxylase	GAD65	0.0186
862	Multidrug resistance-associated protein 1	ABCC1	0.0186
4512	Cytochrome P450 3A4	CYP3A4	0.0184
6837	Serine/threonine-protein kinase 17B	STK17B	0.0183
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0183
290	Prostaglandin G/H synthase 2	PTGS2	0.018
3884	SHMT2 protein	SHMT2	0.0172
3901	SHMT2 protein	SHMT2	0.0172
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0172
3879	Serine hydroxymethyltransferase 2	Not Available	0.0172
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0172
358	Cystathionine beta-synthase	CBS	0.0172
5469	Head decoration protein	shp	0.0168
2310	2-dehydro-3-deoxyphosphooctonate aldolase	kdsA	0.0163
2542	2-dehydro-3-deoxyphosphooctonate aldolase	kdsA	0.0163
6144	Solute carrier family 22 member 2	SLC22A2	0.0162
2457	Bacillolysin	nprS	0.016
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0159
482	Glycine receptor subunit alpha-1	GLRA1	0.0159
586	Aspartate aminotransferase, cytoplasmic	GOT1	0.0156
6085	Fatty acid-binding protein, intestinal	FABP2	0.0156
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0153
33	Cystine/glutamate transporter	SLC7A11	0.0151
4061	Peroxisomal sarcosine oxidase	PIPOX	0.015
4058	Glycine N-acyltransferase-like protein 2	GLYATL2	0.015
4057	Glycine N-acyltransferase	GLYAT	0.015
4059	Glycine N-acyltransferase-like protein 1	GLYATL1	0.015
4056	N-arachidonyl glycine receptor	GPR18	0.015
1088	5-aminolevulinate synthase, erythroid-specific, mitochondrial	ALAS2	0.015
4055	Bile acid CoA:amino acid N-acyltransferase	BAAT	0.015
4060	Vesicular inhibitory amino acid transporter	SLC32A1	0.015
1236	Sodium- and chloride-dependent glycine transporter 1	SLC6A9	0.015
1466	Glycyl-tRNA synthetase	GARS	0.015
4062	Sodium- and chloride-dependent glycine transporter 2	SLC6A5	0.015
184	L-serine dehydratase	SDS	0.015
431	Serine racemase	SRR	0.015
491	Serine palmitoyltransferase 1	SPTLC1	0.015
727	Serine palmitoyltransferase 2	SPTLC2	0.015
2183	Fatty acid-binding protein, adipocyte	FABP4	0.015
338	DNA polymerase	UL30	0.0149
379	DNA polymerase	UL54	0.0149
697	DNA polymerase	ORF28	0.0149
2482	DNA polymerase	43	0.0149
4104	DNA polymerase	BALF5	0.0149
815	Histidyl-tRNA synthetase, cytoplasmic	HARS	0.0147
96	Histidine ammonia-lyase	HAL	0.0147
6257	Histidine ammonia-lyase	Not Available	0.0147
6536	Histidine ammonia-lyase	hutH	0.0147
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0147
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0147
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0147
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0142
38	Cystinosin	CTNS	0.0141
3998	B(0,+)-type amino acid transporter 1	SLC7A9	0.0141
1963	Neutral and basic amino acid transport protein rBAT	SLC3A1	0.0141
4119	Cytochrome P450 2D6	CYP2D6	0.014
2599	Tyrosine-protein kinase HCK	HCK	0.0139
4118	Cytochrome P450 3A5	CYP3A5	0.0138
150	Cationic amino acid transporter 3	SLC7A3	0.0137
235	High-affinity cationic amino acid transporter 1	SLC7A1	0.0137
58	Cationic amino acid transporter 4	SLC7A4	0.0137
207	Glutathione synthetase	GSS	0.0136
5269	Glutathione synthetase	gshB	0.0136
6149	Solute carrier family 22 member 10	SLC22A10	0.0135
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0135
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.0134
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0134
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0133
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0133
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0133
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0131
3877	Growth-inhibiting protein 18	GIG18	0.0131
6016	Cytochrome P450 2C19	CYP2C19	0.013
426	Aspartate aminotransferase, mitochondrial	GOT2	0.0125
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0125
672	Prostaglandin F2-alpha receptor	PTGFR	0.0123
3977	ASRGL1 protein	ASRGL1	0.0121
499	Arginine decarboxylase	ADC	0.0119
263	Neutral amino acid transporter B(0)	SLC1A5	0.0119
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0117
665	Phosphoserine aminotransferase	PSAT1	0.0116
4652	Phosphoserine aminotransferase	serC	0.0116
1039	Histone deacetylase 9	HDAC9	0.0116
801	Kynurenine/alpha-aminoadipate aminotransferase mitochondrial	AADAT	0.0116
3895	Kynurenine--oxoglutarate transaminase 3	CCBL2	0.0116
420	Glutamate decarboxylase 1	GAD1	0.0116
3900	Glutamate decarboxylase 1	GAD1	0.0116
1792	Tissue-type plasminogen activator	PLAT	0.0116
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0116
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0115
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0114
89	Cysteine sulfinic acid decarboxylase	CSAD	0.0114
62	Glycine receptor subunit beta	GLRB	0.0114
1483	Membrane copper amine oxidase	AOC3	0.0112
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0111
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0111
701	Isoleucine-tRNA synthetase	IARS	0.011
546	Isoleucyl-tRNA synthetase, cytoplasmic	IARS	0.011
4080	Isoleucyl-tRNA synthetase, mitochondrial	IARS2	0.011
221	Lysyl-tRNA synthetase	KARS	0.0109
4054	Glycine cleavage system H protein, mitochondrial	GCSH	0.0108
4092	Probable asparaginyl-tRNA synthetase, mitochondrial	NARS2	0.0107
669	Asparaginyl-tRNA synthetase, cytoplasmic	NARS	0.0107
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0107
6145	Solute carrier family 22 member 1	SLC22A1	0.0106
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0106
833	Organic cation/carnitine transporter 1	SLC22A4	0.0106
4109	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	0.0104
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0103
6218	Pannexin-1	PANX1	0.0101
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0099
3874	Proline synthetase co-transcribed bacterial homolog protein	PROSC	0.0099
72	Seryl-tRNA synthetase, cytoplasmic	SARS	0.0099
411	Glycine N-methyltransferase	GNMT	0.0099
383	Glycine amidinotransferase, mitochondrial	GATM	0.0099
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0098
868	Cystathionine gamma-lyase	CTH	0.0096
42	Phenylalanyl-tRNA synthetase alpha chain	FARSA	0.0096
6602	Phenylalanyl-tRNA synthetase alpha chain	pheS	0.0096
31	Phenylalanyl-tRNA synthetase, mitochondrial	FARS2	0.0096
618	Phenylalanyl-tRNA synthetase beta chain	FARSB	0.0096
6603	Phenylalanyl-tRNA synthetase beta chain	pheT	0.0096
619	Low-affinity cationic amino acid transporter 2	SLC7A2	0.0095
828	Phenylalanine-4-hydroxylase	PAH	0.0092
3109	Phenylalanine-4-hydroxylase	phhA	0.0092
668	Glutamate--cysteine ligase regulatory subunit	GCLM	0.0092
820	Glycine receptor subunit alpha-2	GLRA2	0.0092
461	Glycine receptor subunit alpha-3	GLRA3	0.0092
2358	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	0.009
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0089
6107	Cytochrome P450 3A7	CYP3A7	0.0088
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0087
558	Solute carrier family 12 member 1	SLC12A1	0.0084
357	Carbonic anhydrase 2	CA2	0.0084
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0082
626	Cysteine dioxygenase type 1	CDO1	0.0081
3887	Phosphorylase	PYGB	0.008
3883	Ornithine aminotransferase variant	Not Available	0.008
3906	Serine dehydratase-like	SDSL	0.008
306	Pyridoxal phosphate phosphatase	PDXP	0.008
3914	Alanine-glyoxylate aminotransferase homolog	TLH6	0.008
3911	Uncharacterized protein C20orf38	SPTLC3	0.008
3896	CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase	GADL1	0.008
3908	P-selectin cytoplasmic tail-associated protein	pcap	0.008
3881	Selenocysteine lyase variant	Not Available	0.008
3891	Putative L-Dopa decarboxylase	DDC	0.008
3878	GAD1 protein	GAD1	0.008
3903	Aminolevulinate, delta-, synthase 2	ALAS2	0.008
3915	Cysteine sulfinic acid decarboxylase-related protein 1	CSAD	0.008
855	Sphingosine-1-phosphate lyase 1	SGPL1	0.008
3880	Serine hydroxymethyltransferase 1	Not Available	0.008
3875	Glycogen phosphorylase, brain form	PYGB	0.008
3893	DDC protein	DDC	0.008
3882	Brain glycogen phosphorylase variant	Not Available	0.008
3910	O-phosphoseryl-tRNA(Sec) selenium transferase	SEPSECS	0.008
3909	Hepatic peroxysomal alanine:glyoxylate aminotransferase	Not Available	0.008
3886	Migration-inducing protein 4	ALAS1	0.008
3894	KIAA0251 protein	PDXDC1	0.008
3905	Molybdenum cofactor sulfurase	MOCOS	0.008
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.008
6031	Cytochrome P450 3A43	CYP3A43	0.008
186	Glutamate--cysteine ligase catalytic subunit	GCLC	0.008
3426	Glutamine synthetase	glnA	0.008
3987	Glutamine synthetase	GLUL	0.008
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0079
6106	Cytochrome P450 2C18	CYP2C18	0.0078
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0077
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0075
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0074
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0074
6167	Organic solute transporter subunit beta	OSTB	0.0073
6166	Organic solute transporter subunit alpha	OSTA	0.0073
3991	Glutamine-dependent NAD(+) synthetase	NADSYN1	0.0072
3984	Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial	PET112L	0.0072
5	Glutaminase liver isoform, mitochondrial	GLS2	0.0072
917	Glutaminase kidney isoform, mitochondrial	GLS	0.0072
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0072
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0072
3982	Phosphoribosylformylglycinamidine synthase	PFAS	0.0072
5261	Phosphoribosylformylglycinamidine synthase	purL	0.0072
4200	Cytochrome P450 1A2	CYP1A2	0.007
6013	Cytochrome P450 2E1	CYP2E1	0.0068
248	Pyrroline-5-carboxylate reductase 1	PYCR1	0.0068
802	Pyrroline-5-carboxylate reductase 2	PYCR2	0.0068
3939	Amine oxidase [flavin-containing] B	MAOB	0.0067
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0067
1671	Excitatory amino acid transporter 3	SLC1A1	0.0067
543	Penicillin-binding protein 1B	mrcB	0.0067
6186	Penicillin-binding protein 1B	ponB	0.0067
6822	Penicillin-binding protein 1b	pbp1b	0.0067
6844	Penicillin-binding protein 1b	pbp1b	0.0067
740	Argininosuccinate synthase	ASS1	0.0067
865	Argininosuccinate synthase	ASS1	0.0067
2680	Argininosuccinate synthase	argG	0.0067
3194	Argininosuccinate synthase	argG	0.0067
3941	Amine oxidase [flavin-containing] A	MAOA	0.0066
645	Penicillin-binding protein 1A	mrcA	0.0065
5805	Penicillin-binding protein 1A	ponA	0.0065
6185	Penicillin-binding protein 1A	mrcA	0.0065
6799	Penicillin-binding protein 1A	pbpA	0.0065
5718	Cytochrome P450 2A6	CYP2A6	0.0065
3014	Ribonuclease UK114	HRSP12	0.0064
5428	Replication protein	repA	0.0064
3617	Non-heme chloroperoxidase	cpo	0.0064
5426	Non-heme chloroperoxidase	cpo	0.0064
5427	Hydroxyquinol 1,2-dioxygenase	chqB	0.0064
3718	Hydrogen peroxide-inducible genes activator	oxyR	0.0064
3018	HTH-type transcriptional regulator malT	malT	0.0064
159	Penicillin-binding protein 2B	penA	0.0064
6121	Penicillin-binding protein 2B	penA	0.0064
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0064
472	Ornithine aminotransferase, mitochondrial	OAT	0.0063
210	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase	EPRS	0.0063
776	Bile salt export pump	ABCB11	0.0063
203	Pyridoxine-5'-phosphate oxidase	PNPO	0.0059
6137	Multidrug resistance-associated protein 6	ABCC6	0.0059
6030	Cytochrome P450 2B6	CYP2B6	0.0058
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0058
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0056
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0056
810	Heme oxygenase 1	HMOX1	0.0055
3391	Heme oxygenase 1	pbsA1	0.0055
2958	Probable tautomerase ydcE	pptA	0.0055
4024	Mitochondrial glutamate carrier 2	SLC25A18	0.0055
4025	Mitochondrial glutamate carrier 1	SLC25A22	0.0055
4026	Aspartyl aminopeptidase	DNPEP	0.0055
4019	Excitatory amino acid transporter 4	SLC1A6	0.0055
1047	Excitatory amino acid transporter 2	SLC1A2	0.0055
4021	Probable glutamyl-tRNA synthetase, mitochondrial	EARS2	0.0055
4023	N-acetylglutamate synthase, mitochondrial	NAGS	0.0055
1912	Excitatory amino acid transporter 1	SLC1A3	0.0055
915	Delta 1-pyrroline-5-carboxylate synthetase	ALDH18A1	0.0055
4022	Glutamate--ammonia ligase domain-containing protein 1	LGSN	0.0055
664	Glutamate decarboxylase 2	GAD2	0.0055
3890	Glutamate decarboxylase 2	GAD2	0.0055
4016	Excitatory amino acid transporter 5	SLC1A7	0.0055
919	Glutamate receptor, ionotropic kainate 4	GRIK4	0.0055
922	Glutamate receptor 4	GRIA4	0.0055
927	Metabotropic glutamate receptor 8	GRM8	0.0055
4018	Glutamate receptor delta-2 subunit	GRID2	0.0055
926	Metabotropic glutamate receptor 7	GRM7	0.0055
4020	Glutamyl aminopeptidase	ENPEP	0.0055
920	Glutamate receptor, ionotropic kainate 5	GRIK5	0.0055
925	Metabotropic glutamate receptor 4	GRM4	0.0055
924	Glutamate receptor, ionotropic kainate 3	GRIK3	0.0055
4027	Glutamate receptor delta-1 subunit	GRID1	0.0055
4017	5-oxoprolinase	OPLAH	0.0055
2573	Cocaine esterase	cocE	0.0055
7263	Cocaine esterase	Not Available	0.0055
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0055
468	Cytochrome P450 4A11	CYP4A11	0.0054
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0054
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0054
3603	Chlorocatechol 1,2-dioxygenase	clcA	0.0054
3115	Ras-related protein Rab-9	RAB9A	0.0054
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0053
313	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	NDUFB3	0.0053
607	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	NDUFA2	0.0053
374	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NDUFB1	0.0053
475	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial	NDUFB2	0.0053
30	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	NDUFV3	0.0053
555	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	NDUFS4	0.0053
247	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	NDUFA1	0.0053
236	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	NDUFA6	0.0053
343	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	NDUFC1	0.0053
568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	NDUFB7	0.0053
598	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	0.0053
190	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	NDUFA4	0.0053
755	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NDUFA3	0.0053
353	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	0.0053
152	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	0.0053
405	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUFA8	0.0053
272	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	NDUFB10	0.0053
300	NADH-ubiquinone oxidoreductase chain 4L	MT-ND4L	0.0053
99	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	NDUFS5	0.0053
446	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	NDUFA7	0.0053
525	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	NDUFA5	0.0053
219	NADH-ubiquinone oxidoreductase chain 3	MT-ND3	0.0053
41	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	0.0053
104	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	NDUFS6	0.0053
417	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	NDUFB6	0.0053
324	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	NDUFB4	0.0053
671	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial	PDHA2	0.0053
582	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	0.0053
829	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFA12	0.0053
609	15-hydroxyprostaglandin dehydrogenase [NAD+]	HPGD	0.0053
602	Acyl carrier protein, mitochondrial	NDUFAB1	0.0053
384	NADH-ubiquinone oxidoreductase chain 6	MT-ND6	0.0053
372	Estradiol 17-beta-dehydrogenase 3	HSD17B3	0.0053
644	Heme oxygenase 2	HMOX2	0.0053
4982	Heme oxygenase 2	pbsA2	0.0053
711	UDP-glucose 6-dehydrogenase	UGDH	0.0053
3672	UDP-glucose 6-dehydrogenase	hasB	0.0053
656	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFB9	0.0053
729	GDP-L-fucose synthetase	TSTA3	0.0053
3463	GDP-L-fucose synthetase	fcl	0.0053
487	Aldo-keto reductase family 1 member C4	AKR1C4	0.0053
746	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	NDUFB8	0.0053
167	L-lactate dehydrogenase C chain	LDHC	0.0053
270	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	NDUFB5	0.0053
141	3-hydroxyisobutyrate dehydrogenase, mitochondrial	HIBADH	0.0053
196	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	0.0053
721	NADH-ubiquinone oxidoreductase chain 2	MT-ND2	0.0053
231	Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic	GPD1	0.0053
91	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	NDUFA10	0.0053
14	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	0.0053
335	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA9	0.0053
616	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	0.0053
9	Estradiol 17-beta-dehydrogenase 2	HSD17B2	0.0053
628	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial	PDHA1	0.0053
848	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	0.0053
149	Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	0.0053
608	NADH-ubiquinone oxidoreductase chain 4	MT-ND4	0.0053
496	Aldehyde dehydrogenase 3B1	ALDH3B1	0.0053
112	L-lactate dehydrogenase A-like 6B	LDHAL6B	0.0053
662	Fatty aldehyde dehydrogenase	ALDH3A2	0.0053
531	Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	0.0053
107	C-4 methylsterol oxidase	SC4MOL	0.0053
180	D-3-phosphoglycerate dehydrogenase	PHGDH	0.0053
3726	D-3-phosphoglycerate dehydrogenase	serA	0.0053
4291	D-3-phosphoglycerate dehydrogenase	serA	0.0053
258	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	0.0053
271	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ALDH4A1	0.0053
326	L-lactate dehydrogenase A-like 6A	LDHAL6A	0.0053
637	NADH-ubiquinone oxidoreductase chain 5	MT-ND5	0.0053
206	3-keto-steroid reductase	HSD17B7	0.0053
50	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	NSDHL	0.0053
216	Aldehyde dehydrogenase 3B2	ALDH3B2	0.0053
145	Corticosteroid 11-beta-dehydrogenase isozyme 2	HSD11B2	0.0053
643	Peroxisomal bifunctional enzyme	EHHADH	0.0053
548	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	0.0053
288	Trifunctional enzyme subunit alpha, mitochondrial	HADHA	0.0053
393	GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase	H6PD	0.0053
539	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	0.0053
34	7-dehydrocholesterol reductase	DHCR7	0.0053
449	Ornithine decarboxylase	ODC1	0.0053
171	Cysteine dioxygenase	CDO-1	0.0053
774	Cysteinyl-tRNA synthetase, cytoplasmic	CARS	0.0052
1314	Thiamine transporter 2	SLC19A3	0.0052
4064	Probable cysteinyl-tRNA synthetase, mitochondrial	CARS2	0.0052
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0052
816	Biliverdin reductase A	BLVRA	0.0052
579	Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	0.0052
792	Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	0.0052
316	4-trimethylaminobutyraldehyde dehydrogenase	ALDH9A1	0.0052
834	Arginase-2, mitochondrial	ARG2	0.0051
921	Glutamate receptor 2	GRIA2	0.005
577	Argininosuccinate lyase	ASL	0.0049
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0049
3971	CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase	CAD	0.0049
480	Methionine-R-sulfoxide reductase B2	MSRB2	0.0048
317	Methionine-R-sulfoxide reductase	SEPX1	0.0048
3996	Betaine--homocysteine S-methyltransferase 2	BHMT2	0.0048
3921	Methionine adenosyltransferase 2 subunit beta	MAT2B	0.0048
3995	Methionyl-tRNA synthetase, mitochondrial	MARS2	0.0048
600	Methionyl-tRNA synthetase, cytoplasmic	MARS	0.0048
4037	Hypothetical protein	GPX1	0.0047
4297	Hypothetical protein	SP_1951	0.0047
4521	Hypothetical protein	BC_2969	0.0047
4540	Hypothetical protein	TM_1070	0.0047
4555	Hypothetical protein	MT1739	0.0047
4569	Hypothetical protein	mshD	0.0047
4578	Hypothetical protein	PA3270	0.0047
4747	Hypothetical protein	PA3967	0.0047
5177	Hypothetical protein	TM_0096	0.0047
5194	Hypothetical protein	PA1204	0.0047
5240	Hypothetical protein	Rv2991	0.0047
5370	Hypothetical protein	TM_1158	0.0047
5710	Hypothetical protein	Tb927.5.1360	0.0047
4545	Molybdopterin-converting factor subunit 2	moaE	0.0047
4527	Putative hydrolase ycdX	ycdX	0.0047
4106	Guanylate kinase	GUK1	0.0047
4516	Guanylate kinase	gmk	0.0047
4538	Hypothetical protein VC1899	VC_1899	0.0047
4536	Transcriptional regulator, IclR family	TM_0065	0.0047
2501	Protein ygbM	ygbM	0.0047
4514	Citrate lyase beta subunit-like protein	citE	0.0047
4781	Citrate lyase beta subunit-like protein	DR_1240	0.0047
4524	Mannose-6-phosphate isomerase	yvyI	0.0047
4522	Arginine N-succinyltransferase subunit alpha	astA	0.0047
4547	Iron binding protein FbpA	fbpA	0.0047
4529	Oxalate decarboxylase oxdC	oxdC	0.0047
4546	Aminotransferase, putative	TM_1131	0.0047
658	Para-aminobenzoate synthase component 1	pabB	0.0047
4526	Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein	TM_1223	0.0047
4535	Glutaconyl-CoA decarboxylase subunit alpha	gcdA	0.0047
4548	Gyrase B	gyrB	0.0047
4515	Peripheral plasma membrane protein CASK	CASK	0.0047
625	Glutamate carboxypeptidase 2	FOLH1	0.0046
10	Glycogen phosphorylase, liver form	PYGL	0.0046
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0046
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0045
350	3-hydroxyacyl-CoA dehydrogenase type-2	HSD17B10	0.0045
646	Malate dehydrogenase, cytoplasmic	MDH1	0.0044
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.0044
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.0044
454	Peroxisomal multifunctional enzyme type 2	HSD17B4	0.0044
635	Estradiol 17-beta-dehydrogenase 8	HSD17B8	0.0044
666	NADP-dependent malic enzyme	ME1	0.0044
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0043
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0043
363	NADP-dependent malic enzyme, mitochondrial	ME3	0.0043
916	Metabotropic glutamate receptor 1	GRM1	0.0043
1999	Methylated-DNA--protein-cysteine methyltransferase	MGMT	0.0043
4496	C-terminal-binding protein 1	CTBP1	0.0043
6020	Aldehyde oxidase	AOX1	0.0042
328	Sorbitol dehydrogenase	SORD	0.0042
597	Dihydropteridine reductase	QDPR	0.0042
396	Alcohol dehydrogenase 4	ADH4	0.0042
6026	Alcohol dehydrogenase 6	ADH6	0.0042
2693	Heat-labile enterotoxin B chain	eltB	0.0042
4532	Gephyrin	GPHN	0.0041
923	Glutamate receptor 3	GRIA3	0.0041
56	Delta-aminolevulinic acid dehydratase	ALAD	0.0041
2356	Delta-aminolevulinic acid dehydratase	hemB	0.0041
3613	Delta-aminolevulinic acid dehydratase	hemB	0.0041
3674	Delta-aminolevulinic acid dehydratase	hemB	0.0041
4533	Glyoxalase family protein	BC_1747	0.0041
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0041
3237	Beta-lactamase OXA-2	bla	0.0041
4542	Glutaminase 1	glsA1	0.0041
4544	Glutaminase 1	glsA1	0.0041
857	Malate dehydrogenase, mitochondrial	MDH2	0.0041
191	Peptide methionine sulfoxide reductase	MSRA	0.0041
2929	(S)-2-haloacid dehalogenase	dhlB	0.0041
2995	(S)-2-haloacid dehalogenase	Not Available	0.0041
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0041
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0041
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0041
4528	Phenazine biosynthesis protein PhzD	phzD1	0.0041
3759	Glutathione S-transferase	gst	0.004
4541	Glutathione S-transferase	GST	0.004
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.004
3261	Signal recognition particle protein	ffh	0.004
4517	Probable butyrate kinase 2	buk2	0.004
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.004
627	11-cis retinol dehydrogenase	RDH5	0.004
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.004
419	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	0.004
11	NAD(P) transhydrogenase, mitochondrial	NNT	0.0039
941	Betaine--homocysteine S-methyltransferase 1	BHMT	0.0039
2230	Catalase	CAT	0.0039
3249	Catalase	katA	0.0039
3625	Catalase	katA	0.0039
4539	Catalase	katA	0.0039
4941	Catalase	katB	0.0039
5682	Ribonuclease pancreatic	RNASE1	0.0039
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0039
365	Dihydrofolate reductase	DHFR	0.0039
2381	Dihydrofolate reductase	DFR1	0.0039
2833	Dihydrofolate reductase	Not Available	0.0039
2931	Dihydrofolate reductase	folA	0.0039
3544	Dihydrofolate reductase	folA	0.0039
3682	Dihydrofolate reductase	folA	0.0039
6642	Dihydrofolate reductase	folA	0.0039
6756	Dihydrofolate reductase	dfrA	0.0039
334	S-adenosylmethionine synthetase isoform type-2	MAT2A	0.0038
12	Alcohol dehydrogenase class 3	ADH5	0.0038
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0038
569	Retinal dehydrogenase 2	ALDH1A2	0.0038
3583	6-phosphogluconolactonase	pgl	0.0037
2775	Dihydroorotate dehydrogenase	pyrD	0.0037
4531	Putative ketoacyl reductase	actIII	0.0037
599	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.0037
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0037
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0037
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0037
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0037
453	S-adenosylmethionine synthetase isoform type-1	MAT1A	0.0036
6148	Multidrug resistance-associated protein 7	ABCC10	0.0036
13	Aminomethyltransferase, mitochondrial	AMT	0.0036
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0036
74	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	0.0036
794	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	GAPDHS	0.0035
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0035
2525	3-phosphoshikimate 1-carboxyvinyltransferase	aroA	0.0035
3201	3-phosphoshikimate 1-carboxyvinyltransferase	aroA	0.0035
4085	Peptidyl-prolyl cis-trans isomerase C	PPIC	0.0035
4088	Probable prolyl-tRNA synthetase, mitochondrial	PARS2	0.0035
4083	Peptidyl-prolyl cis-trans isomerase H	PPIH	0.0035
4087	Pyrroline 5-carboxylate reductase isoform	P5CR2	0.0035
1152	Glycogen phosphorylase, muscle form	PYGM	0.0035
4090	Chromosome 14 open reading frame 149	C14orf149	0.0035
4082	Proline oxidase, mitochondrial	PRODH	0.0035
797	Sodium-dependent proline transporter	SLC6A7	0.0035
4086	Peptidyl-prolyl cis-trans isomerase G	PPIG	0.0035
611	Retinal dehydrogenase 1	ALDH1A1	0.0034
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0034
705	Glutamate receptor 1	GRIA1	0.0034
1517	Beta-3 adrenergic receptor	ADRB3	0.0034
166	NAD-dependent malic enzyme, mitochondrial	ME2	0.0034
3587	Gastrotropin	FABP6	0.0034
2688	Peptide deformylase	def	0.0033
2708	Peptide deformylase	def	0.0033
3004	Peptide deformylase	def	0.0033
4337	Peptide deformylase	def	0.0033
4338	Peptide deformylase	def	0.0033
5368	Peptide deformylase	def	0.0033
5371	Peptide deformylase	def	0.0033
6375	Peptide deformylase	def	0.0033
6378	Peptide deformylase	def	0.0033
6379	Peptide deformylase	def	0.0033
6776	Peptide deformylase	def	0.0033
6900	Peptide deformylase	def	0.0033
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0033
4534	Cytohesin-2	CYTH2	0.0033
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0033
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0033
279	Tyrosinase	TYR	0.0033
840	Methionine synthase reductase, mitochondrial	MTRR	0.0033
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.0032
2548	Subtilisin Carlsberg	apr	0.0032
251	Alcohol dehydrogenase 1A	ADH1A	0.0032
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0032
163	D(1B) dopamine receptor	DRD5	0.0032
4269	Hypoxanthine-guanine phosphoribosyltransferase, putative	HGPRTase	0.0032
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0031
2632	Adenylosuccinate synthetase	purA	0.0031
3323	Adenylosuccinate synthetase	purA	0.0031
3975	Adenylosuccinate synthetase	ADSS	0.0031
4598	Adenylosuccinate synthetase	Adss	0.0031
6817	Adenylosuccinate synthetase	purA	0.0031
3972	Adenylosuccinate synthetase isozyme 2	ADSS	0.0031
533	Aminoacylase-1	ACY1	0.0031
3969	Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole- succinocarboxamide synthase	PAICS	0.0031
799	Aspartyl-tRNA synthetase, cytoplasmic	DARS	0.0031
209	Aspartoacylase	ASPA	0.0031
3979	Aspartoacylase-2	ACY3	0.0031
3976	Aspartyl-tRNA synthetase, mitochondrial	DARS2	0.0031
513	Calcium-binding mitochondrial carrier protein Aralar2	SLC25A13	0.0031
305	Mitochondrial aspartate-glutamate carrier protein	SLC25A13	0.0031
262	Calcium-binding mitochondrial carrier protein Aralar1	SLC25A12	0.0031
809	Methionine synthase	MTR	0.0031
2935	Methionine synthase	metH	0.0031
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0031
432	D(4) dopamine receptor	DRD4	0.003
5818	Folate receptor alpha	FOLR1	0.003
654	Flavin reductase	BLVRB	0.003
4084	Peptidyl-prolyl cis-trans isomerase B	PPIB	0.003
638	D(3) dopamine receptor	DRD3	0.0029
4000	Prolyl 4-hydroxylase subunit alpha-2	P4HA2	0.0029
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0029
7	Nitric oxide synthase, inducible	NOS2	0.0029
1008	CTP synthase 1	CTPS	0.0029
3988	Protein-glutamine gamma-glutamyltransferase K	TGM1	0.0029
3985	Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2	GFPT2	0.0029
3990	Protein-glutamine gamma-glutamyltransferase 4	TGM4	0.0029
3986	Protein-glutamine gamma-glutamyltransferase 6	TGM6	0.0029
3992	Protein-glutamine gamma-glutamyltransferase Z	TGM7	0.0029
3983	Protein-glutamine gamma-glutamyltransferase 5	TGM5	0.0029
3989	Glutaminyl-tRNA synthetase	QARS	0.0029
291	Nitric-oxide synthase, endothelial	NOS3	0.0029
3811	Cytochrome P450 19A1	CYP19A1	0.0028
444	Alcohol dehydrogenase 1B	ADH1B	0.0028
380	Cytochrome P450 17A1	CYP17A1	0.0028
760	Fibroblast growth factor 1	FGF1	0.0027
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0027
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0027
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0027
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0027
3027	Streptavidin	Not Available	0.0027
585	Aspartyl/asparaginyl beta-hydroxylase	ASPH	0.0027
2554	Peptidyl-prolyl cis-trans isomerase, mitochondrial	PPIF	0.0027
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0026
293	Gamma-glutamyl hydrolase	GGH	0.0026
2795	Methionine aminopeptidase 2	METAP2	0.0026
23	D(1A) dopamine receptor	DRD1	0.0026
714	Glutathione reductase, mitochondrial	GSR	0.0026
789	Alpha-1D adrenergic receptor	ADRA1D	0.0026
3949	Prolyl 3-hydroxylase 2	LEPREL1	0.0025
3945	Prolyl 3-hydroxylase 1	LEPRE1	0.0025
3951	Prolyl 3-hydroxylase 3	LEPREL2	0.0025
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0025
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0025
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0025
378	Alpha-2C adrenergic receptor	ADRA2C	0.0025
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0025
831	D(2) dopamine receptor	DRD2	0.0024
1596	Protein-glutamine gamma-glutamyltransferase 2	TGM2	0.0024
629	Alpha-2B adrenergic receptor	ADRA2B	0.0024
1650	Heme carrier protein 1	SLC46A1	0.0024
193	Beta-1 adrenergic receptor	ADRB1	0.0024
6	Coagulation factor XIII A chain	F13A1	0.0024
76	Nitric-oxide synthase, brain	NOS1	0.0024
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.0023
766	Beta-2 adrenergic receptor	ADRB2	0.0023
517	Alcohol dehydrogenase 1C	ADH1C	0.0023
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0023
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0023
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0023
632	Alpha-1B adrenergic receptor	ADRA1B	0.0023
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0023
413	Amidophosphoribosyltransferase	PPAT	0.0023
2515	Amidophosphoribosyltransferase	purF	0.0023
3714	Amidophosphoribosyltransferase	purF	0.0023
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0022
3947	Xanthine dehydrogenase/oxidase	XDH	0.0022
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0022
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0022
318	Alpha-2A adrenergic receptor	ADRA2A	0.0022
822	Aldose reductase	AKR1B1	0.0021
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0021
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0021
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0021
3978	Adenylosuccinate synthetase isozyme 1	ADSSL1	0.0021
556	Alpha-1A adrenergic receptor	ADRA1A	0.002
2339	Protein-glutamine gamma-glutamyltransferase E	TGM3	0.002
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.002
6024	Cytochrome P450 1A1	CYP1A1	0.0019
24	Thymidylate synthase	TMP1	0.0018
359	Thymidylate synthase	TYMS	0.0018
2626	Thymidylate synthase	thyA	0.0018
2729	Thymidylate synthase	thyA	0.0018
5352	Thymidylate synthase	THYA	0.0018

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00119 - Pyruvic acid

Targets

Transporters

Predictions