DT-Web

DB00135 - L-Tyrosine


Identification
Name L-Tyrosine
Accession Number DB00135 (NUTR00059)
Type small molecule
Description A non-essential amino acid. In animals it is synthesized from phenylalanine. It is also the precursor of epinephrine; thyroid hormones; and melanin. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 181.1885
Groups approved
Monoisotopic Weight 181.073893223
Pharmacology
Indication Tyrosine is claimed to act as an effective antidepressant, however results are mixed. Tyrosine has also been claimed to reduce stress and combat narcolepsy and chronic fatigue, however these claims have been refuted by some studies.
Mechanism of action Tyrosine is produced in cells by hydroxylating the essential amino acid phenylalanine. This relationship is much like that between cysteine and methionine. Half of the phenylalanine required goes into the production of tyrosine; if the diet is rich in tyrosine itself, the requirements for phenylalanine are reduced by about 50%. The mechanism of L-tyrosine's antidepressant activity can be accounted for by the precursor role of L-tyrosine in the synthesis of the neurotransmitters norepinephrine and dopamine. Elevated brain norepinephrine and dopamine levels are thought to be associated with antidepressant effects.
Absorption L-tyrosine is absorbed from the small intestine by a sodium-dependent active transport process.
Protein binding Not Available
Biotransformation In the liver, L-tyrosine is involved in a number of biochemical reactions, including protein synthesis and oxidative catabolic reactions. L-tyrosine that is not metabolized in the liver is distributed via the systemic circulation to the various tissues of the body.
Route of elimination Not Available
Toxicity L-Tyrosine has very low toxicity. There have been very few reports of toxicity. LD50 (oral, rat) > 5110 mg/kg.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Tyrosine 3-monooxygenase
Name Tyrosine 3-monooxygenase
Gene Name TH
Pharmacological action unknown
Actions binder
References
  • Olsovska J, Novotna J, Flieger M, Spizek J: Assay of tyrosine hydroxylase based on high-performance liquid chromatography separation and quantification of l-dopa and l-tyrosine. Biomed Chromatogr. 2007 Jun 29;. - Pubmed
  • Bodnar I, Hechtl D, Szekacs D, Olah M, Nagy GM: Effect of local (intracerebral and intracerebroventricular) administration of tyrosine hydroxylase inhibitor on the neuroendocrine dopaminergic neurons and prolactin release. Ideggyogy Sz. 2007 Mar 30;60(3-4):177-81. - Pubmed
  • Rostrup M, Fossbakk A, Hauge A, Kleppe R, Gnaiger E, Haavik J: Oxygen dependence of tyrosine hydroxylase. Amino Acids. 2007 May 23;. - Pubmed
  • Richards AB, Scheel TA, Wang K, Henkemeyer M, Kromer LF: EphB1 null mice exhibit neuronal loss in substantia nigra pars reticulata and spontaneous locomotor hyperactivity. Eur J Neurosci. 2007 May;25(9):2619-28. - Pubmed
  • Ugriumov MV: [Brain neurons partly expressing monoaminergic phenotype: distribution, development, and functional significance] Usp Fiziol Nauk. 2007 Apr-Jun;38(2):3-25. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.0875
Tyrosyl-tRNA synthetase, mitochondrial
Name Tyrosyl-tRNA synthetase, mitochondrial
Gene Name YARS2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Zhang Y, Wang L, Schultz PG, Wilson IA: Crystal structures of apo wild-type M. jannaschii tyrosyl-tRNA synthetase (TyrRS) and an engineered TyrRS specific for O-methyl-L-tyrosine. Protein Sci. 2005 May;14(5):1340-9. - Pubmed
  • Kiga D, Sakamoto K, Kodama K, Kigawa T, Matsuda T, Yabuki T, Shirouzu M, Harada Y, Nakayama H, Takio K, Hasegawa Y, Endo Y, Hirao I, Yokoyama S: An engineered Escherichia coli tyrosyl-tRNA synthetase for site-specific incorporation of an unnatural amino acid into proteins in eukaryotic translation and its application in a wheat germ cell-free system. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):9715-20. Epub 2002 Jul 3. - Pubmed
  • Kobayashi T, Nureki O, Ishitani R, Yaremchuk A, Tukalo M, Cusack S, Sakamoto K, Yokoyama S: Structural basis for orthogonal tRNA specificities of tyrosyl-tRNA synthetases for genetic code expansion. Nat Struct Biol. 2003 Jun;10(6):425-32. - Pubmed
DTHybrid score 0.5897
Tyrosyl-tRNA synthetase, cytoplasmic
Name Tyrosyl-tRNA synthetase, cytoplasmic
Gene Name YARS
Pharmacological action unknown
Actions Not Available
References
  • Bonnefond L, Frugier M, Touze E, Lorber B, Florentz C, Giege R, Rudinger-Thirion J, Sauter C: Tyrosyl-tRNA synthetase: the first crystallization of a human mitochondrial aminoacyl-tRNA synthetase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Apr 1;63(Pt 4):338-41. Epub 2007 Mar 30. - Pubmed
DTHybrid score 1.3238
Tyrosine aminotransferase
Name Tyrosine aminotransferase
Gene Name TAT
Pharmacological action unknown
Actions Not Available
References
  • Dong S, Kang S, Gu TL, Kardar S, Fu H, Lonial S, Khoury HJ, Khuri F, Chen J: 14-3-3 Integrates prosurvival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1-transformed hematopoietic cells. Blood. 2007 Jul 1;110(1):360-9. Epub 2007 Mar 27. - Pubmed
DTHybrid score 0.47

Transporters


Monocarboxylate transporter 8
Name Monocarboxylate transporter 8
Gene Name SLC16A2
Actions inhibitor
References
  • Friesema EC, Ganguly S, Abdalla A, Manning Fox JE, Halestrap AP, Visser TJ: Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter. J Biol Chem. 2003 Oct 10;278(41):40128-35. Epub 2003 Jul 18. - Pubmed
DTHybrid score 0.4449
Monocarboxylate transporter 10
Name Monocarboxylate transporter 10
Gene Name SLC16A10
Actions inhibitor
References
  • Kim DK, Kanai Y, Matsuo H, Kim JY, Chairoungdua A, Kobayashi Y, Enomoto A, Cha SH, Goya T, Endou H: The human T-type amino acid transporter-1: characterization, gene organization, and chromosomal location. Genomics. 2002 Jan;79(1):95-103. - Pubmed
  • Kim DK, Kanai Y, Chairoungdua A, Matsuo H, Cha SH, Endou H: Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. J Biol Chem. 2001 May 18;276(20):17221-8. Epub 2001 Feb 20. - Pubmed
DTHybrid score 0.6131

Predictions


Id Partner name Gene Name Score
5493 Tyrosine aminotransferase Not Available 0.47
828 Phenylalanine-4-hydroxylase PAH 0.1484
3109 Phenylalanine-4-hydroxylase phhA 0.1484
6240 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 PIN1 0.1122
31 Phenylalanyl-tRNA synthetase, mitochondrial FARS2 0.111
42 Phenylalanyl-tRNA synthetase alpha chain FARSA 0.111
6602 Phenylalanyl-tRNA synthetase alpha chain pheS 0.111
618 Phenylalanyl-tRNA synthetase beta chain FARSB 0.1109
6603 Phenylalanyl-tRNA synthetase beta chain pheT 0.1109
3574 Tyrosyl-tRNA synthetase tyrS 0.0992
3703 Tyrosyl-tRNA synthetase tyrS 0.0992
6878 Tyrosyl-tRNA synthetase YARS 0.0992
687 Tyrosine-protein phosphatase non-receptor type 1 PTPN1 0.0856
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0849
3526 Pseudomonalisin pcp 0.0792
134 Tryptophan 5-hydroxylase 1 TPH1 0.0756
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0571
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.057
54 Prothrombin F2 0.0505
501 Leucine carboxyl methyltransferase 1 LCMT1 0.0467
675 Leucine carboxyl methyltransferase 2 LCMT2 0.0466
846 Leucyl-tRNA synthetase, cytoplasmic LARS 0.0466
227 Probable leucyl-tRNA synthetase, mitochondrial LARS2 0.0466
2675 Pteridine reductase 1 PTR1 0.0465
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0446
1566 Corticoliberin CRH 0.0413
2360 Dihydroneopterin aldolase folB 0.0391
4063 Tryptophanyl-tRNA synthetase, mitochondrial WARS2 0.0382
90 Tryptophan 5-hydroxylase 2 TPH2 0.0382
594 Thyroxine-binding globulin SERPINA7 0.0365
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0337
758 Thyroid hormone receptor alpha THRA 0.0327
7 Nitric oxide synthase, inducible NOS2 0.0326
291 Nitric-oxide synthase, endothelial NOS3 0.0321
765 Indoleamine 2,3-dioxygenase IDO1 0.0313
252 Tryptophanyl-tRNA synthetase, cytoplasmic WARS 0.0289
2532 Pantoate--beta-alanine ligase panC 0.0285
6012 Tryptophan 2,3-dioxygenase TDO2 0.0276
2452 Tryptophanyl-tRNA synthetase trpS 0.0269
346 Thyroid hormone receptor beta-1 THRB 0.0267
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0264
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.026
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.026
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.025
6645 D-amino-acid oxidase DAO 0.0245
290 Prostaglandin G/H synthase 2 PTGS2 0.0238
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0235
5925 Neuropeptide Y NPY 0.0231
314 System N amino acid transporter 1 SLC38A3 0.0229
397 Monocarboxylate transporter 3 SLC16A8 0.0218
195 Monocarboxylate transporter 7 SLC16A6 0.0218
218 Monocarboxylate transporter 5 SLC16A4 0.0218
429 Monocarboxylate transporter 6 SLC16A5 0.0217
534 Threonine synthase-like 1 THNSL1 0.0201
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.02
4069 Threonyl-tRNA synthetase, mitochondrial TARS2 0.0197
261 Threonyl-tRNA synthetase, cytoplasmic TARS 0.0197
246 Valyl-tRNA synthetase VARS 0.0196
738 Monocarboxylate transporter 1 SLC16A1 0.0193
500 Monocarboxylate transporter 4 SLC16A3 0.0193
373 Transthyretin TTR 0.0192
489 Monocarboxylate transporter 2 SLC16A7 0.0192
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0187
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0177
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0176
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0172
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0171
5469 Head decoration protein shp 0.0168
3 Histidine decarboxylase HDC 0.0166
52 Pyruvate kinase isozymes R/L PKLR 0.0166
771 Pyruvate carboxylase, mitochondrial PC 0.0165
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0163
2457 Bacillolysin nprS 0.016
601 Propionyl-CoA carboxylase beta chain, mitochondrial PCCB 0.0157
349 Serine--pyruvate aminotransferase AGXT 0.0151
358 Cystathionine beta-synthase CBS 0.0149
587 Serum albumin ALB 0.0148
815 Histidyl-tRNA synthetase, cytoplasmic HARS 0.0147
96 Histidine ammonia-lyase HAL 0.0147
6257 Histidine ammonia-lyase Not Available 0.0147
6536 Histidine ammonia-lyase hutH 0.0147
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0147
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0147
98 Pyruvate kinase isozymes M1/M2 PKM2 0.0146
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0145
38 Cystinosin CTNS 0.0141
3998 B(0,+)-type amino acid transporter 1 SLC7A9 0.0141
1963 Neutral and basic amino acid transport protein rBAT SLC3A1 0.0141
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0138
150 Cationic amino acid transporter 3 SLC7A3 0.0137
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.0137
58 Cationic amino acid transporter 4 SLC7A4 0.0137
735 Alanine aminotransferase 1 GPT 0.0134
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0134
3904 Alanine aminotransferase 2 GPT2 0.0134
6141 Sodium/bile acid cotransporter SLC10A1 0.0133
33 Cystine/glutamate transporter SLC7A11 0.0133
169 Cysteine desulfurase, mitochondrial NFS1 0.0127
431 Serine racemase SRR 0.0125
184 L-serine dehydratase SDS 0.0125
491 Serine palmitoyltransferase 1 SPTLC1 0.0125
727 Serine palmitoyltransferase 2 SPTLC2 0.0125
1588 Multidrug resistance protein 1 ABCB1 0.0125
4924 Cytochrome P450 2C8 CYP2C8 0.0124
3877 Growth-inhibiting protein 18 GIG18 0.0123
3977 ASRGL1 protein ASRGL1 0.0121
263 Neutral amino acid transporter B(0) SLC1A5 0.0119
426 Aspartate aminotransferase, mitochondrial GOT2 0.0116
701 Isoleucine-tRNA synthetase IARS 0.011
546 Isoleucyl-tRNA synthetase, cytoplasmic IARS 0.011
4080 Isoleucyl-tRNA synthetase, mitochondrial IARS2 0.011
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.011
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.011
420 Glutamate decarboxylase 1 GAD1 0.011
3900 Glutamate decarboxylase 1 GAD1 0.011
665 Phosphoserine aminotransferase PSAT1 0.011
4652 Phosphoserine aminotransferase serC 0.011
221 Lysyl-tRNA synthetase KARS 0.0109
4092 Probable asparaginyl-tRNA synthetase, mitochondrial NARS2 0.0107
669 Asparaginyl-tRNA synthetase, cytoplasmic NARS 0.0107
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0105
5650 NimA-related protein DR_0842 0.0101
72 Seryl-tRNA synthetase, cytoplasmic SARS 0.0099
6142 Solute carrier family 22 member 8 SLC22A8 0.0097
499 Arginine decarboxylase ADC 0.0097
619 Low-affinity cationic amino acid transporter 2 SLC7A2 0.0095
482 Glycine receptor subunit alpha-1 GLRA1 0.0093
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.0093
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0093
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0091
914 Formimidoyltransferase-cyclodeaminase FTCD 0.009
89 Cysteine sulfinic acid decarboxylase CSAD 0.009
3426 Glutamine synthetase glnA 0.0088
3987 Glutamine synthetase GLUL 0.0088
435 Kynureninase KYNU 0.0086
4654 Kynureninase kynU 0.0086
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0085
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0085
5 Glutaminase liver isoform, mitochondrial GLS2 0.0085
917 Glutaminase kidney isoform, mitochondrial GLS 0.0085
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0085
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0085
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0084
5261 Phosphoribosylformylglycinamidine synthase purL 0.0084
1671 Excitatory amino acid transporter 3 SLC1A1 0.0078
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0077
3874 Proline synthetase co-transcribed bacterial homolog protein PROSC 0.0076
833 Organic cation/carnitine transporter 1 SLC22A4 0.0075
868 Cystathionine gamma-lyase CTH 0.0075
4026 Aspartyl aminopeptidase DNPEP 0.007
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.007
1912 Excitatory amino acid transporter 1 SLC1A3 0.007
4019 Excitatory amino acid transporter 4 SLC1A6 0.007
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.007
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.007
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.007
664 Glutamate decarboxylase 2 GAD2 0.007
3890 Glutamate decarboxylase 2 GAD2 0.007
4016 Excitatory amino acid transporter 5 SLC1A7 0.007
1047 Excitatory amino acid transporter 2 SLC1A2 0.007
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.007
4018 Glutamate receptor delta-2 subunit GRID2 0.007
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.007
4027 Glutamate receptor delta-1 subunit GRID1 0.007
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.007
4017 5-oxoprolinase OPLAH 0.007
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.007
926 Metabotropic glutamate receptor 7 GRM7 0.007
922 Glutamate receptor 4 GRIA4 0.007
927 Metabotropic glutamate receptor 8 GRM8 0.007
925 Metabotropic glutamate receptor 4 GRM4 0.007
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.007
4020 Glutamyl aminopeptidase ENPEP 0.007
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0069
740 Argininosuccinate synthase ASS1 0.0067
865 Argininosuccinate synthase ASS1 0.0067
2680 Argininosuccinate synthase argG 0.0067
3194 Argininosuccinate synthase argG 0.0067
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0065
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0065
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0065
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0063
3884 SHMT2 protein SHMT2 0.0059
3901 SHMT2 protein SHMT2 0.0059
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0059
3879 Serine hydroxymethyltransferase 2 Not Available 0.0059
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0059
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0059
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0059
532 Neutral amino acid transporter A SLC1A4 0.0057
4070 Probable alanyl-tRNA synthetase, mitochondrial AARS2 0.0057
323 Alanyl-tRNA synthetase, cytoplasmic AARS 0.0057
3911 Uncharacterized protein C20orf38 SPTLC3 0.0057
3906 Serine dehydratase-like SDSL 0.0057
3881 Selenocysteine lyase variant Not Available 0.0057
3887 Phosphorylase PYGB 0.0057
3908 P-selectin cytoplasmic tail-associated protein pcap 0.0057
3915 Cysteine sulfinic acid decarboxylase-related protein 1 CSAD 0.0057
3883 Ornithine aminotransferase variant Not Available 0.0057
306 Pyridoxal phosphate phosphatase PDXP 0.0057
3880 Serine hydroxymethyltransferase 1 Not Available 0.0057
3896 CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase GADL1 0.0057
3891 Putative L-Dopa decarboxylase DDC 0.0057
3914 Alanine-glyoxylate aminotransferase homolog TLH6 0.0057
3878 GAD1 protein GAD1 0.0057
3909 Hepatic peroxysomal alanine:glyoxylate aminotransferase Not Available 0.0057
3893 DDC protein DDC 0.0057
3910 O-phosphoseryl-tRNA(Sec) selenium transferase SEPSECS 0.0057
855 Sphingosine-1-phosphate lyase 1 SGPL1 0.0057
3903 Aminolevulinate, delta-, synthase 2 ALAS2 0.0057
3886 Migration-inducing protein 4 ALAS1 0.0057
3894 KIAA0251 protein PDXDC1 0.0057
3875 Glycogen phosphorylase, brain form PYGB 0.0057
3882 Brain glycogen phosphorylase variant Not Available 0.0057
3905 Molybdenum cofactor sulfurase MOCOS 0.0057
625 Glutamate carboxypeptidase 2 FOLH1 0.0056
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0054
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0054
171 Cysteine dioxygenase CDO-1 0.0053
774 Cysteinyl-tRNA synthetase, cytoplasmic CARS 0.0052
1314 Thiamine transporter 2 SLC19A3 0.0052
4064 Probable cysteinyl-tRNA synthetase, mitochondrial CARS2 0.0052
207 Glutathione synthetase GSS 0.0052
5269 Glutathione synthetase gshB 0.0052
916 Metabotropic glutamate receptor 1 GRM1 0.0052
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0051
834 Arginase-2, mitochondrial ARG2 0.0051
593 Proton-coupled amino acid transporter 1 SLC36A1 0.0051
3913 Glutamic acid decarboxylase GAD65 0.005
923 Glutamate receptor 3 GRIA3 0.005
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.005
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0049
577 Argininosuccinate lyase ASL 0.0049
3971 CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase CAD 0.0049
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0048
480 Methionine-R-sulfoxide reductase B2 MSRB2 0.0048
317 Methionine-R-sulfoxide reductase SEPX1 0.0048
3996 Betaine--homocysteine S-methyltransferase 2 BHMT2 0.0048
3921 Methionine adenosyltransferase 2 subunit beta MAT2B 0.0048
3995 Methionyl-tRNA synthetase, mitochondrial MARS2 0.0048
600 Methionyl-tRNA synthetase, cytoplasmic MARS 0.0048
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0048
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0047
4512 Cytochrome P450 3A4 CYP3A4 0.0046
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0043
1999 Methylated-DNA--protein-cysteine methyltransferase MGMT 0.0043
705 Glutamate receptor 1 GRIA1 0.0042
472 Ornithine aminotransferase, mitochondrial OAT 0.0042
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0041
191 Peptide methionine sulfoxide reductase MSRA 0.0041
626 Cysteine dioxygenase type 1 CDO1 0.004
203 Pyridoxine-5'-phosphate oxidase PNPO 0.004
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0039
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0038
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0036
4085 Peptidyl-prolyl cis-trans isomerase C PPIC 0.0035
4088 Probable prolyl-tRNA synthetase, mitochondrial PARS2 0.0035
4083 Peptidyl-prolyl cis-trans isomerase H PPIH 0.0035
4087 Pyrroline 5-carboxylate reductase isoform P5CR2 0.0035
4090 Chromosome 14 open reading frame 149 C14orf149 0.0035
4082 Proline oxidase, mitochondrial PRODH 0.0035
797 Sodium-dependent proline transporter SLC6A7 0.0035
4086 Peptidyl-prolyl cis-trans isomerase G PPIG 0.0035
449 Ornithine decarboxylase ODC1 0.0034
1517 Beta-3 adrenergic receptor ADRB3 0.0034
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0034
840 Methionine synthase reductase, mitochondrial MTRR 0.0033
163 D(1B) dopamine receptor DRD5 0.0032
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0032
2632 Adenylosuccinate synthetase purA 0.0031
3323 Adenylosuccinate synthetase purA 0.0031
3975 Adenylosuccinate synthetase ADSS 0.0031
4598 Adenylosuccinate synthetase Adss 0.0031
6817 Adenylosuccinate synthetase purA 0.0031
3972 Adenylosuccinate synthetase isozyme 2 ADSS 0.0031
533 Aminoacylase-1 ACY1 0.0031
3969 Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole- succinocarboxamide synthase PAICS 0.0031
799 Aspartyl-tRNA synthetase, cytoplasmic DARS 0.0031
209 Aspartoacylase ASPA 0.0031
3979 Aspartoacylase-2 ACY3 0.0031
3976 Aspartyl-tRNA synthetase, mitochondrial DARS2 0.0031
513 Calcium-binding mitochondrial carrier protein Aralar2 SLC25A13 0.0031
305 Mitochondrial aspartate-glutamate carrier protein SLC25A13 0.0031
262 Calcium-binding mitochondrial carrier protein Aralar1 SLC25A12 0.0031
809 Methionine synthase MTR 0.0031
2935 Methionine synthase metH 0.0031
432 D(4) dopamine receptor DRD4 0.003
10 Glycogen phosphorylase, liver form PYGL 0.003
4084 Peptidyl-prolyl cis-trans isomerase B PPIB 0.003
638 D(3) dopamine receptor DRD3 0.0029
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0029
921 Glutamate receptor 2 GRIA2 0.0029
1008 CTP synthase 1 CTPS 0.0029
3988 Protein-glutamine gamma-glutamyltransferase K TGM1 0.0029
3985 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2 GFPT2 0.0029
3990 Protein-glutamine gamma-glutamyltransferase 4 TGM4 0.0029
3986 Protein-glutamine gamma-glutamyltransferase 6 TGM6 0.0029
3992 Protein-glutamine gamma-glutamyltransferase Z TGM7 0.0029
3983 Protein-glutamine gamma-glutamyltransferase 5 TGM5 0.0029
3989 Glutaminyl-tRNA synthetase QARS 0.0029
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0027
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0027
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0027
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0027
2554 Peptidyl-prolyl cis-trans isomerase, mitochondrial PPIF 0.0027
2795 Methionine aminopeptidase 2 METAP2 0.0026
23 D(1A) dopamine receptor DRD1 0.0026
3917 Methylenetetrahydrofolate reductase MTHFR 0.0026
789 Alpha-1D adrenergic receptor ADRA1D 0.0026
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.0025
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.0025
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.0025
378 Alpha-2C adrenergic receptor ADRA2C 0.0025
831 D(2) dopamine receptor DRD2 0.0024
1596 Protein-glutamine gamma-glutamyltransferase 2 TGM2 0.0024
629 Alpha-2B adrenergic receptor ADRA2B 0.0024
118 Organic cation/carnitine transporter 2 SLC22A5 0.0024
193 Beta-1 adrenergic receptor ADRB1 0.0024
6 Coagulation factor XIII A chain F13A1 0.0024
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0023
766 Beta-2 adrenergic receptor ADRB2 0.0023
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0023
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0023
632 Alpha-1B adrenergic receptor ADRA1B 0.0023
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0023
413 Amidophosphoribosyltransferase PPAT 0.0023
2515 Amidophosphoribosyltransferase purF 0.0023
3714 Amidophosphoribosyltransferase purF 0.0023
1152 Glycogen phosphorylase, muscle form PYGM 0.0022
4058 Glycine N-acyltransferase-like protein 2 GLYATL2 0.0022
4057 Glycine N-acyltransferase GLYAT 0.0022
4059 Glycine N-acyltransferase-like protein 1 GLYATL1 0.0022
4056 N-arachidonyl glycine receptor GPR18 0.0022
4061 Peroxisomal sarcosine oxidase PIPOX 0.0022
4055 Bile acid CoA:amino acid N-acyltransferase BAAT 0.0022
1236 Sodium- and chloride-dependent glycine transporter 1 SLC6A9 0.0022
4062 Sodium- and chloride-dependent glycine transporter 2 SLC6A5 0.0022
4060 Vesicular inhibitory amino acid transporter SLC32A1 0.0022
1088 5-aminolevulinate synthase, erythroid-specific, mitochondrial ALAS2 0.0022
1466 Glycyl-tRNA synthetase GARS 0.0022
318 Alpha-2A adrenergic receptor ADRA2A 0.0022
3978 Adenylosuccinate synthetase isozyme 1 ADSSL1 0.0021
556 Alpha-1A adrenergic receptor ADRA1A 0.002
2339 Protein-glutamine gamma-glutamyltransferase E TGM3 0.002
4119 Cytochrome P450 2D6 CYP2D6 0.0018
4054 Glycine cleavage system H protein, mitochondrial GCSH 0.0017
62 Glycine receptor subunit beta GLRB 0.0017
383 Glycine amidinotransferase, mitochondrial GATM 0.0016
411 Glycine N-methyltransferase GNMT 0.0016
5682 Ribonuclease pancreatic RNASE1 0.0016
820 Glycine receptor subunit alpha-2 GLRA2 0.0014
461 Glycine receptor subunit alpha-3 GLRA3 0.0014
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