DT-Web

DB00114 - Pyridoxal Phosphate


Identification
Name Pyridoxal Phosphate
Accession Number DB00114 (NUTR00045)
Type small molecule
Description This is the active form of vitamin B6 serving as a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. During transamination of amino acids, pyridoxal phosphate is transiently converted into pyridoxamine phosphate (pyridoxamine). [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 247.1419
Groups nutraceutical
Monoisotopic Weight 247.024573569
Pharmacology
Indication For nutritional supplementation and for treating dietary shortage or imbalance.
Mechanism of action Pyridoxal Phosphate is a coenzyme of many enzymatic reactions. It is the active form of vitamin B6 which comprises three natural organic compounds, pyridoxal, pyridoxamine and pyridoxine. Pyridoxal phosphate acts as a coenzyme in all transamination reactions, and in some decarboxylation and deamination reactions of amino acids. The aldehyde group of pyridoxal phosphate forms a Schiff-base linkage with the epsilon-amino group of a specific lysine group of the aminotransferase enzyme. The alpha-amino group of the amino acid substrate displaces the epsilon-amino group of the active-site lysine residue. The resulting aldimine becomes deprotonated to become a quinoid intermediate, which in turn accepts a proton at a different position to become a ketimine. The resulting ketimine is hydrolysed so that the amino group remains on the protein complex.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Alanine--glyoxylate aminotransferase 2, mitochondrial
Name Alanine--glyoxylate aminotransferase 2, mitochondrial
Gene Name AGXT2
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Lee IS, Muragaki Y, Ideguchi T, Hase T, Tsuji M, Ooshima A, Okuno E, Kido R: Molecular cloning and sequencing of a cDNA encoding alanine-glyoxylate aminotransferase 2 from rat kidney. J Biochem (Tokyo). 1995 Apr;117(4):856-62. - Pubmed
  • Takada Y, Mori T, Noguchi T: The effect of vitamin B6 deficiency on alanine: glyoxylate aminotransferase isoenzymes in rat liver. Arch Biochem Biophys. 1984 Feb 15;229(1):1-6. - Pubmed
DTHybrid score 0.9008
Glutamate decarboxylase 1
Name Glutamate decarboxylase 1
Gene Name GAD1
Pharmacological action unknown
Actions cofactor
References
  • Hwang IK, Yoo KY, Kim DS, Eum WS, Park JK, Park J, Kwon OS, Kang TC, Choi SY, Won MH: Changes of pyridoxal kinase expression and activity in the gerbil hippocampus following transient forebrain ischemia. Neuroscience. 2004;128(3):511-8. - Pubmed
  • Rust E, Martin DL, Chen CH: Cofactor and tryptophan accessibility and unfolding of brain glutamate decarboxylase. Arch Biochem Biophys. 2001 Aug 15;392(2):333-40. - Pubmed
  • Jin H, Sha D, Wei J, Davis KM, Wu H, Jin Y, Wu JY: Effect of apocalmodulin on recombinant human brain glutamic acid decarboxylase. J Neurochem. 2005 Feb;92(4):739-48. - Pubmed
  • Chen CH, Battaglioli G, Martin DL, Hobart SA, Colon W: Distinctive interactions in the holoenzyme formation for two isoforms of glutamate decarboxylase. Biochim Biophys Acta. 2003 Jan 31;1645(1):63-71. - Pubmed
  • Tong JC, Mackay IR, Chin J, Law RH, Fayad K, Rowley MJ: Enzymatic characterization of a recombinant isoform hybrid of glutamic acid decarboxylase (rGAD67/65) expressed in yeast. J Biotechnol. 2002 Aug 7;97(2):183-90. - Pubmed
DTHybrid score 0.7902
Cystathionine beta-synthase
Name Cystathionine beta-synthase
Gene Name CBS
Pharmacological action unknown
Actions cofactor
References
  • Taoka S, Banerjee R: Stopped-flow kinetic analysis of the reaction catalyzed by the full-length yeast cystathionine beta-synthase. J Biol Chem. 2002 Jun 21;277(25):22421-5. Epub 2002 Apr 10. - Pubmed
  • Taoka S, Lepore BW, Kabil O, Ojha S, Ringe D, Banerjee R: Human cystathionine beta-synthase is a heme sensor protein. Evidence that the redox sensor is heme and not the vicinal cysteines in the CXXC motif seen in the crystal structure of the truncated enzyme. Biochemistry. 2002 Aug 20;41(33):10454-61. - Pubmed
  • Mino K, Ishikawa K: Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1. J Bacteriol. 2003 Apr;185(7):2277-84. - Pubmed
  • Evande R, Ojha S, Banerjee R: Visualization of PLP-bound intermediates in hemeless variants of human cystathionine beta-synthase: evidence that lysine 119 is a general base. Arch Biochem Biophys. 2004 Jul 15;427(2):188-96. - Pubmed
  • Linnebank M, Janosik M, Kozich V, Pronicka E, Kubalska J, Sokolova J, Linnebank A, Schmidt E, Leyendecker C, Klockgether T, Kraus JP, Koch HG: The cystathionine beta-synthase (CBS) mutation c.1224-2A>C in Central Europe: Vitamin B6 nonresponsiveness and a common ancestral haplotype. Hum Mutat. 2004 Oct;24(4):352-3. - Pubmed
DTHybrid score 1.0944
Kynureninase
Name Kynureninase
Gene Name KYNU
Pharmacological action unknown
Actions cofactor
References
  • Momany C, Levdikov V, Blagova L, Lima S, Phillips RS: Three-dimensional structure of kynureninase from Pseudomonas fluorescens. Biochemistry. 2004 Feb 10;43(5):1193-203. - Pubmed
  • Rooseboom M, Vermeulen NP, Groot EJ, Commandeur JN: Tissue distribution of cytosolic beta-elimination reactions of selenocysteine Se-conjugates in rat and human. Chem Biol Interact. 2002 Aug 15;140(3):243-64. - Pubmed
  • Lima S, Khristoforov R, Momany C, Phillips RS: Crystal structure of Homo sapiens kynureninase. Biochemistry. 2007 Mar 13;46(10):2735-44. Epub 2007 Feb 15. - Pubmed
  • Walsh HA, Botting NP: Purification and biochemical characterization of some of the properties of recombinant human kynureninase. Eur J Biochem. 2002 Apr;269(8):2069-74. - Pubmed
DTHybrid score 1.3631
Serine hydroxymethyltransferase, cytosolic
Name Serine hydroxymethyltransferase, cytosolic
Gene Name SHMT1
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Trakatellis A, Dimitriadou A, Exindari M, Christodoulou D, Malissiovas N, Antoniadis A, Haitoglou K: Effect of combination of deoxypyridoxine with known anti-proliferative or immunosuppressive agents on lymphocyte serine hydroxymethyltransferase. Postgrad Med J. 1994;70 Suppl 1:S89-92. - Pubmed
  • Jagath JR, Sharma B, Rao NA, Savithri HS: The role of His-134, -147, and -150 residues in subunit assembly, cofactor binding, and catalysis of sheep liver cytosolic serine hydroxymethyltransferase. J Biol Chem. 1997 Sep 26;272(39):24355-62. - Pubmed
  • Bourguignon J, Neuburger M, Douce R: Resolution and characterization of the glycine-cleavage reaction in pea leaf mitochondria. Properties of the forward reaction catalysed by glycine decarboxylase and serine hydroxymethyltransferase. Biochem J. 1988 Oct 1;255(1):169-78. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.2548
Cysteine desulfurase, mitochondrial
Name Cysteine desulfurase, mitochondrial
Gene Name NFS1
Pharmacological action unknown
Actions cofactor
References
  • Ollagnier-De-Choudens S, Mulliez E, Hewitson KS, Fontecave M: Biotin synthase is a pyridoxal phosphate-dependent cysteine desulfurase. Biochemistry. 2002 Jul 23;41(29):9145-52. - Pubmed
  • You D, Wang L, Yao F, Zhou X, Deng Z: A novel DNA modification by sulfur: DndA is a NifS-like cysteine desulfurase capable of assembling DndC as an iron-sulfur cluster protein in Streptomyces lividans. Biochemistry. 2007 May 22;46(20):6126-33. Epub 2007 May 1. - Pubmed
  • Forlani F, Cereda A, Freuer A, Nimtz M, Leimkuhler S, Pagani S: The cysteine-desulfurase IscS promotes the production of the rhodanese RhdA in the persulfurated form. FEBS Lett. 2005 Dec 19;579(30):6786-90. Epub 2005 Nov 21. - Pubmed
  • Cupp-Vickery JR, Urbina H, Vickery LE: Crystal structure of IscS, a cysteine desulfurase from Escherichia coli. J Mol Biol. 2003 Jul 25;330(5):1049-59. - Pubmed
  • Frazzon J, Fick JR, Dean DR: Biosynthesis of iron-sulphur clusters is a complex and highly conserved process. Biochem Soc Trans. 2002 Aug;30(4):680-5. - Pubmed
DTHybrid score 0.9559
Aspartate aminotransferase, cytoplasmic
Name Aspartate aminotransferase, cytoplasmic
Gene Name GOT1
Pharmacological action unknown
Actions activator
References
  • Hansen CM, Shultz TD: Stability of vitamin B-6-dependent aminotransferase activity in frozen packed erythrocytes is dependent on storage temperature. J Nutr. 2001 May;131(5):1581-3. - Pubmed
  • Eliot AC, Kirsch JF: Modulation of the internal aldimine pK(a)'s of 1-aminocyclopropane-1-carboxylate synthase and aspartate aminotransferase by specific active site residues. Biochemistry. 2002 Mar 19;41(11):3836-42. - Pubmed
  • Cooper AJ, Bruschi SA, Anders MW: Toxic, halogenated cysteine S-conjugates and targeting of mitochondrial enzymes of energy metabolism. Biochem Pharmacol. 2002 Aug 15;64(4):553-64. - Pubmed
  • Waldmann A, Dorr B, Koschizke JW, Leitzmann C, Hahn A: Dietary intake of vitamin B6 and concentration of vitamin B6 in blood samples of German vegans. Public Health Nutr. 2006 Sep;9(6):779-84. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.8061
Ornithine aminotransferase, mitochondrial
Name Ornithine aminotransferase, mitochondrial
Gene Name OAT
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.2083
Ornithine decarboxylase
Name Ornithine decarboxylase
Gene Name ODC1
Pharmacological action unknown
Actions cofactor
References
  • Jackson LK, Goldsmith EJ, Phillips MA: X-ray structure determination of Trypanosoma brucei ornithine decarboxylase bound to D-ornithine and to G418: insights into substrate binding and ODC conformational flexibility. J Biol Chem. 2003 Jun 13;278(24):22037-43. Epub 2003 Apr 2. - Pubmed
  • Jackson LK, Brooks HB, Myers DP, Phillips MA: Ornithine decarboxylase promotes catalysis by binding the carboxylate in a buried pocket containing phenylalanine 397. Biochemistry. 2003 Mar 18;42(10):2933-40. - Pubmed
  • Jackson LK, Baldwin J, Akella R, Goldsmith EJ, Phillips MA: Multiple active site conformations revealed by distant site mutation in ornithine decarboxylase. Biochemistry. 2004 Oct 19;43(41):12990-9. - Pubmed
  • Khomutov AR: Inhibition of enzymes of polyamine biosynthesis by substrate-like O-substituted hydroxylamines. Biochemistry (Mosc). 2002 Oct;67(10):1159-67. - Pubmed
  • Myers DP, Jackson LK, Ipe VG, Murphy GE, Phillips MA: Long-range interactions in the dimer interface of ornithine decarboxylase are important for enzyme function. Biochemistry. 2001 Nov 6;40(44):13230-6. - Pubmed
DTHybrid score 1.3655
Kynurenine/alpha-aminoadipate aminotransferase mitochondrial
Name Kynurenine/alpha-aminoadipate aminotransferase mitochondrial
Gene Name AADAT
Pharmacological action unknown
Actions cofactor
References
  • Goh DL, Patel A, Thomas GH, Salomons GS, Schor DS, Jakobs C, Geraghty MT: Characterization of the human gene encoding alpha-aminoadipate aminotransferase (AADAT). Mol Genet Metab. 2002 Jul;76(3):172-80. - Pubmed
  • Cooper AJ: The role of glutamine transaminase K (GTK) in sulfur and alpha-keto acid metabolism in the brain, and in the possible bioactivation of neurotoxicants. Neurochem Int. 2004 Jun;44(8):557-77. - Pubmed
DTHybrid score 0.782
4-aminobutyrate aminotransferase, mitochondrial
Name 4-aminobutyrate aminotransferase, mitochondrial
Gene Name ABAT
Pharmacological action unknown
Actions inhibitor
References
  • Storici P, De Biase D, Bossa F, Bruno S, Mozzarelli A, Peneff C, Silverman RB, Schirmer T: Structures of gamma-aminobutyric acid (GABA) aminotransferase, a pyridoxal 5'-phosphate, and [2Fe-2S] cluster-containing enzyme, complexed with gamma-ethynyl-GABA and with the antiepilepsy drug vigabatrin. J Biol Chem. 2004 Jan 2;279(1):363-73. Epub 2003 Oct 8. - Pubmed
  • Hwang IK, Yoo KY, Kim do H, Lee BH, Kwon YG, Won MH: Time course of changes in pyridoxal 5'-phosphate (vitamin B6 active form) and its neuroprotection in experimental ischemic damage. Exp Neurol. 2007 Jul;206(1):114-25. Epub 2007 Apr 24. - Pubmed
  • Sulaiman SA, Suliman FE, Barghouthi S: Kinetic studies on the inhibition of GABA-T by gamma-vinyl GABA and taurine. J Enzyme Inhib Med Chem. 2003 Aug;18(4):297-301. - Pubmed
  • Markova M, Peneff C, Hewlins MJ, Schirmer T, John RA: Determinants of substrate specificity in omega-aminotransferases. J Biol Chem. 2005 Oct 28;280(43):36409-16. Epub 2005 Aug 11. - Pubmed
  • Liu W, Peterson PE, Langston JA, Jin X, Zhou X, Fisher AJ, Toney MD: Kinetic and crystallographic analysis of active site mutants of Escherichia coli gamma-aminobutyrate aminotransferase. Biochemistry. 2005 Mar 1;44(8):2982-92. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.1621
Pyridoxine-5'-phosphate oxidase
Name Pyridoxine-5'-phosphate oxidase
Gene Name PNPO
Pharmacological action unknown
Actions cofactor
References
  • Gospe SM Jr: Pyridoxine-dependent seizures: new genetic and biochemical clues to help with diagnosis and treatment. Curr Opin Neurol. 2006 Apr;19(2):148-53. - Pubmed
  • Hwang IK, Kim DW, Jung JY, Yoo KY, Cho JH, Kwon OS, Kang TC, Choi SY, Kim YS, Won MH: Age-dependent changes of pyridoxal phosphate synthesizing enzymes immunoreactivities and activities in the gerbil hippocampal CA1 region. Mech Ageing Dev. 2005 Dec;126(12):1322-30. Epub 2005 Oct 3. - Pubmed
  • Pearl PL, Hartka TR, Taylor J: Diagnosis and Treatment of Neurotransmitter Disorders. Curr Treat Options Neurol. 2006 Nov;8(6):441-450. - Pubmed
  • Hoffmann GF, Schmitt B, Windfuhr M, Wagner N, Strehl H, Bagci S, Franz AR, Mills PB, Clayton PT, Baumgartner MR, Steinmann B, Bast T, Wolf NI, Zschocke J: Pyridoxal 5'-phosphate may be curative in early-onset epileptic encephalopathy. J Inherit Metab Dis. 2007 Feb;30(1):96-9. Epub 2006 Dec 23. - Pubmed
  • Mills PB, Surtees RA, Champion MP, Beesley CE, Dalton N, Scambler PJ, Heales SJ, Briddon A, Scheimberg I, Hoffmann GF, Zschocke J, Clayton PT: Neonatal epileptic encephalopathy caused by mutations in the PNPO gene encoding pyridox(am)ine 5'-phosphate oxidase. Hum Mol Genet. 2005 Apr 15;14(8):1077-86. Epub 2005 Mar 16. - Pubmed
DTHybrid score Not Available
Sphingosine-1-phosphate lyase 1
Name Sphingosine-1-phosphate lyase 1
Gene Name SGPL1
Pharmacological action unknown
Actions cofactor
References
  • Ikeda M, Kihara A, Igarashi Y: Sphingosine-1-phosphate lyase SPL is an endoplasmic reticulum-resident, integral membrane protein with the pyridoxal 5'-phosphate binding domain exposed to the cytosol. Biochem Biophys Res Commun. 2004 Dec 3;325(1):338-43. - Pubmed
  • Bobbin RP: PPADS, an ATP antagonist, attenuates the effects of a moderately intense sound on cochlear mechanics. Hear Res. 2001 Jun;156(1-2):10-6. - Pubmed
DTHybrid score 0.9377
Tyrosine aminotransferase
Name Tyrosine aminotransferase
Gene Name TAT
Pharmacological action unknown
Actions cofactor
References
  • Biagini MR, Tozzi A, Marcucci R, Paniccia R, Fedi S, Milani S, Galli A, Ceni E, Capanni M, Manta R, Abbate R, Surrenti C: Hyperhomocysteinemia and hypercoagulability in primary biliary cirrhosis. World J Gastroenterol. 2006 Mar 14;12(10):1607-12. - Pubmed
  • Clayton TA, Lindon JC, Everett JR, Charuel C, Hanton G, Le Net JL, Provost JP, Nicholson JK: Hepatotoxin-induced hypertyrosinemia and its toxicological significance. Arch Toxicol. 2007 Mar;81(3):201-10. Epub 2006 Aug 11. - Pubmed
  • Kim SY, An JJ, Kim DW, Choi SH, Lee SH, Hwang SI, Kwon OS, Kang TC, Won MH, Cho SW, Park J, Eum WS, Lee KS, Choi SY: Tat-mediated protein transduction of human brain pyridoxine-5-P oxidase into PC12 cells. J Biochem Mol Biol. 2006 Jan 31;39(1):76-83. - Pubmed
  • Shaffer WA, Luong TN, Rothman SC, Kirsch JF: Quantitative chimeric analysis of six specificity determinants that differentiate Escherichia coli aspartate from tyrosine aminotransferase. Protein Sci. 2002 Dec;11(12):2848-59. - Pubmed
  • Venhorst J, ter Laak AM, Meijer M, van de Wetering I, Commandeur JN, Rooseboom M, Vermeulen NP: Modeling and molecular dynamics of glutamine transaminase K/cysteine conjugate beta-lyase. J Mol Graph Model. 2003 Sep;22(1):55-70. - Pubmed
DTHybrid score 0.7635
Kynurenine--oxoglutarate transaminase 1
Name Kynurenine--oxoglutarate transaminase 1
Gene Name CCBL1
Pharmacological action unknown
Actions cofactor
References
  • Cooper AJ, Bruschi SA, Anders MW: Toxic, halogenated cysteine S-conjugates and targeting of mitochondrial enzymes of energy metabolism. Biochem Pharmacol. 2002 Aug 15;64(4):553-64. - Pubmed
  • Mosca M, Croci C, Mostardini M, Breton J, Malyszko J, Avanzi N, Toma S, Benatti L, Gatti S: Tissue expression and translational control of rat kynurenine aminotransferase/glutamine transaminase K mRNAs. Biochim Biophys Acta. 2003 Jul 9;1628(1):1-10. - Pubmed
  • Zhang L, Cooper AJ, Krasnikov BF, Xu H, Bubber P, Pinto JT, Gibson GE, Hanigan MH: Cisplatin-induced toxicity is associated with platinum deposition in mouse kidney mitochondria in vivo and with selective inactivation of the alpha-ketoglutarate dehydrogenase complex in LLC-PK1 cells. Biochemistry. 2006 Jul 25;45(29):8959-71. - Pubmed
  • Venhorst J, ter Laak AM, Meijer M, van de Wetering I, Commandeur JN, Rooseboom M, Vermeulen NP: Modeling and molecular dynamics of glutamine transaminase K/cysteine conjugate beta-lyase. J Mol Graph Model. 2003 Sep;22(1):55-70. - Pubmed
  • Cooper AJ, Pinto JT: Cysteine S-conjugate beta-lyases. Amino Acids. 2006 Feb;30(1):1-15. Epub 2006 Feb 6. - Pubmed
DTHybrid score 0.846
Threonine synthase-like 1
Name Threonine synthase-like 1
Gene Name THNSL1
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9044
Glycogen phosphorylase, liver form
Name Glycogen phosphorylase, liver form
Gene Name PYGL
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Beauchamp NJ, Taybert J, Champion MP, Layet V, Heinz-Erian P, Dalton A, Tanner MS, Pronicka E, Sharrard MJ: High frequency of missense mutations in glycogen storage disease type VI. J Inherit Metab Dis. 2007 Oct;30(5):722-34. Epub 2007 Aug 21. - Pubmed
DTHybrid score 1.6553
Serine palmitoyltransferase 2
Name Serine palmitoyltransferase 2
Gene Name SPTLC2
Pharmacological action unknown
Actions cofactor
References
  • Hanada K: Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism. Biochim Biophys Acta. 2003 Jun 10;1632(1-3):16-30. - Pubmed
  • Tamura K, Mitsuhashi N, Hara-Nishimura I, Imai H: Characterization of an Arabidopsis cDNA encoding a subunit of serine palmitoyltransferase, the initial enzyme in sphingolipid biosynthesis. Plant Cell Physiol. 2001 Nov;42(11):1274-81. - Pubmed
  • Gable K, Han G, Monaghan E, Bacikova D, Natarajan M, Williams R, Dunn TM: Mutations in the yeast LCB1 and LCB2 genes, including those corresponding to the hereditary sensory neuropathy type I mutations, dominantly inactivate serine palmitoyltransferase. J Biol Chem. 2002 Mar 22;277(12):10194-200. Epub 2002 Jan 7. - Pubmed
  • Ikushiro H, Hayashi H, Kagamiyama H: A water-soluble homodimeric serine palmitoyltransferase from Sphingomonas paucimobilis EY2395T strain. Purification, characterization, cloning, and overproduction. J Biol Chem. 2001 May 25;276(21):18249-56. Epub 2001 Mar 12. - Pubmed
  • Tamura K, Nishiura H, Mori J, Imai H: Cloning and characterization of a cDNA encoding serine palmitoyltransferase in Arabidopsis thaliana. Biochem Soc Trans. 2000 Dec;28(6):745-7. - Pubmed
DTHybrid score 1.1259
Cysteine sulfinic acid decarboxylase
Name Cysteine sulfinic acid decarboxylase
Gene Name CSAD
Pharmacological action unknown
Actions cofactor
References
  • Skoldberg F, Rorsman F, Perheentupa J, Landin-Olsson M, Husebye ES, Gustafsson J, Kampe O: Analysis of antibody reactivity against cysteine sulfinic acid decarboxylase, a pyridoxal phosphate-dependent enzyme, in endocrine autoimmune disease. J Clin Endocrinol Metab. 2004 Apr;89(4):1636-40. - Pubmed
DTHybrid score 0.852
Histidine decarboxylase
Name Histidine decarboxylase
Gene Name HDC
Pharmacological action unknown
Actions cofactor
References
  • Skoldberg F, Portela-Gomes GM, Grimelius L, Nilsson G, Perheentupa J, Betterle C, Husebye ES, Gustafsson J, Ronnblom A, Rorsman F, Kampe O: Histidine decarboxylase, a pyridoxal phosphate-dependent enzyme, is an autoantigen of gastric enterochromaffin-like cells. J Clin Endocrinol Metab. 2003 Apr;88(4):1445-52. - Pubmed
  • Moya-Garcia AA, Pino-Angeles A, Sanchez-Jimenez F: New structural insights to help in the search for selective inhibitors of mammalian pyridoxal 5'-phosphate-dependent histidine decarboxylase . 4. Synthesis, metabolism and release of histamine. Inflamm Res. 2006 Apr;55 Suppl 1:S55-6. - Pubmed
  • Landete JM, Pardo I, Ferrer S: Histamine, histidine, and growth-phase mediated regulation of the histidine decarboxylase gene in lactic acid bacteria isolated from wine. FEMS Microbiol Lett. 2006 Jul;260(1):84-90. - Pubmed
  • Skoldberg F, Rorsman F, Perheentupa J, Landin-Olsson M, Husebye ES, Gustafsson J, Kampe O: Analysis of antibody reactivity against cysteine sulfinic acid decarboxylase, a pyridoxal phosphate-dependent enzyme, in endocrine autoimmune disease. J Clin Endocrinol Metab. 2004 Apr;89(4):1636-40. - Pubmed
  • Graham DE, Xu H, White RH: Methanococcus jannaschii uses a pyruvoyl-dependent arginine decarboxylase in polyamine biosynthesis. J Biol Chem. 2002 Jun 28;277(26):23500-7. Epub 2002 Apr 29. - Pubmed
DTHybrid score 0.8849
Arginine decarboxylase
Name Arginine decarboxylase
Gene Name ADC
Pharmacological action unknown
Actions cofactor
References
  • Graham DE, Xu H, White RH: Methanococcus jannaschii uses a pyruvoyl-dependent arginine decarboxylase in polyamine biosynthesis. J Biol Chem. 2002 Jun 28;277(26):23500-7. Epub 2002 Apr 29. - Pubmed
  • Patel CN, Adcock RS, Sell KG, Oliveira MA: Crystallization, X-ray diffraction and oligomeric characterization of arginine decarboxylase from Yersinia pestis, a key polyamine biosynthetic enzyme. Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 2):2396-8. Epub 2004 Nov 26. - Pubmed
  • Kidron H, Repo S, Johnson MS, Salminen TA: Functional classification of amino acid decarboxylases from the alanine racemase structural family by phylogenetic studies. Mol Biol Evol. 2007 Jan;24(1):79-89. Epub 2006 Sep 22. - Pubmed
  • Arena ME, Manca de Nadra MC: Biogenic amine production by Lactobacillus. J Appl Microbiol. 2001 Feb;90(2):158-62. - Pubmed
  • Shah R, Akella R, Goldsmith EJ, Phillips MA: X-ray structure of Paramecium bursaria Chlorella virus arginine decarboxylase: insight into the structural basis for substrate specificity. Biochemistry. 2007 Mar 13;46(10):2831-41. Epub 2007 Feb 17. - Pubmed
DTHybrid score 0.7606
L-serine dehydratase
Name L-serine dehydratase
Gene Name SDS
Pharmacological action unknown
Actions cofactor
References
  • Sun L, Bartlam M, Liu Y, Pang H, Rao Z: Crystal structure of the pyridoxal-5'-phosphate-dependent serine dehydratase from human liver. Protein Sci. 2005 Mar;14(3):791-8. Epub 2005 Feb 2. - Pubmed
  • Yamada T, Komoto J, Takata Y, Ogawa H, Pitot HC, Takusagawa F: Crystal structure of serine dehydratase from rat liver. Biochemistry. 2003 Nov 11;42(44):12854-65. - Pubmed
  • Sun L, Li X, Dong Y, Yang M, Liu Y, Han X, Zhang X, Pang H, Rao Z: Crystallization and preliminary crystallographic analysis of human serine dehydratase. Acta Crystallogr D Biol Crystallogr. 2003 Dec;59(Pt 12):2297-9. Epub 2003 Nov 27. - Pubmed
  • Ogawa H, Gomi T, Nishizawa M, Hayakawa Y, Endo S, Hayashi K, Ochiai H, Takusagawa F, Pitot HC, Mori H, Sakurai H, Koizumi K, Saiki I, Oda H, Fujishita T, Miwa T, Maruyama M, Kobayashi M: Enzymatic and biochemical properties of a novel human serine dehydratase isoform. Biochim Biophys Acta. 2006 May;1764(5):961-71. Epub 2006 Mar 20. - Pubmed
  • Cicchillo RM, Baker MA, Schnitzer EJ, Newman EB, Krebs C, Booker SJ: Escherichia coli L-serine deaminase requires a [4Fe-4S] cluster in catalysis. J Biol Chem. 2004 Jul 30;279(31):32418-25. Epub 2004 May 19. - Pubmed
DTHybrid score 1.1268
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
Name 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial
Gene Name GCAT
Pharmacological action unknown
Actions cofactor
References
  • Schmidt A, Sivaraman J, Li Y, Larocque R, Barbosa JA, Smith C, Matte A, Schrag JD, Cygler M: Three-dimensional structure of 2-amino-3-ketobutyrate CoA ligase from Escherichia coli complexed with a PLP-substrate intermediate: inferred reaction mechanism. Biochemistry. 2001 May 1;40(17):5151-60. - Pubmed
DTHybrid score 0.8478
Glycine dehydrogenase [decarboxylating], mitochondrial
Name Glycine dehydrogenase [decarboxylating], mitochondrial
Gene Name GLDC
Pharmacological action unknown
Actions cofactor
References
  • Nakai T, Nakagawa N, Maoka N, Masui R, Kuramitsu S, Kamiya N: Structure of P-protein of the glycine cleavage system: implications for nonketotic hyperglycinemia. EMBO J. 2005 Apr 20;24(8):1523-36. Epub 2005 Mar 24. - Pubmed
  • Igamberdiev AU, Ivlev AA, Bykova NV, Threlkeld CN, Lea PJ, Gardestrom P: Decarboxylation of glycine contributes to carbon isotope fractionation in photosynthetic organisms. Photosynth Res. 2001;67(3):177-84. - Pubmed
DTHybrid score 0.8473
Alanine aminotransferase 1
Name Alanine aminotransferase 1
Gene Name GPT
Pharmacological action unknown
Actions cofactor
References
  • Cheung PY, Fong CC, Ng KT, Lam WC, Leung YC, Tsang CW, Yang M, Wong MS: Interaction between pyridoxal kinase and pyridoxal-5-phosphate-dependent enzymes. J Biochem (Tokyo). 2003 Nov;134(5):731-8. - Pubmed
  • Halfon P, Imbert-Bismut F, Messous D, Antoniotti G, Benchetrit D, Cart-Lamy P, Delaporte G, Doutheau D, Klump T, Sala M, Thibaud D, Trepo E, Thabut D, Myers RP, Poynard T: A prospective assessment of the inter-laboratory variability of biochemical markers of fibrosis (FibroTest) and activity (ActiTest) in patients with chronic liver disease. Comp Hepatol. 2002 Dec 30;1(1):3. - Pubmed
  • Inubushi T, Takasawa T, Tuboi Y, Watanabe N, Aki K, Katunuma N: Changes of glucose metabolism and skin-collagen neogenesis in vitamin B6 deficiency. Biofactors. 2005;23(2):59-67. - Pubmed
  • Baines CJ, McKeown-Eyssen GE, Riley N, Cole DE, Marshall L, Loescher B, Jazmaji V: Case-control study of multiple chemical sensitivity, comparing haematology, biochemistry, vitamins and serum volatile organic compound measures. Occup Med (Lond). 2004 Sep;54(6):408-18. Epub 2004 Sep 3. - Pubmed
  • Beranek M, Drsata J, Palicka V: Inhibitory effect of glycation on catalytic activity of alanine aminotransferase. Mol Cell Biochem. 2001 Feb;218(1-2):35-9. - Pubmed
DTHybrid score 0.9241
Phosphoserine aminotransferase
Name Phosphoserine aminotransferase
Gene Name PSAT1
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Battchikova N, Himanen JP, Ahjolahti M, Korpela T: Phosphoserine aminotransferase from Bacillus circulans subsp. alkalophilus: purification, gene cloning and sequencing. Biochim Biophys Acta. 1996 Jul 18;1295(2):187-94. - Pubmed
  • Hester G, Stark W, Moser M, Kallen J, Markovic-Housley Z, Jansonius JN: Crystal structure of phosphoserine aminotransferase from Escherichia coli at 2.3 A resolution: comparison of the unligated enzyme and a complex with alpha-methyl-l-glutamate. J Mol Biol. 1999 Feb 26;286(3):829-50. - Pubmed
  • Kapetaniou EG, Thanassoulas A, Dubnovitsky AP, Nounesis G, Papageorgiou AC: Effect of pH on the structure and stability of Bacillus circulans ssp. alkalophilus phosphoserine aminotransferase: thermodynamic and crystallographic studies. Proteins. 2006 Jun 1;63(4):742-53. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.782
5-aminolevulinate synthase, nonspecific, mitochondrial
Name 5-aminolevulinate synthase, nonspecific, mitochondrial
Gene Name ALAS1
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Nakamura I, Isobe N, Nakamura N, Kamihara T, Fukui S: Mechanism of thiamine-induced respiratory deficiency in Saccharomyces carlsbergensis. J Bacteriol. 1981 Sep;147(3):954-61. - Pubmed
  • Harigae H, Furuyama K, Kudo K, Hayashi N, Yamamoto M, Sassa S, Sasaki T: A novel mutation of the erythroid-specific gamma-Aminolevulinate synthase gene in a patient with non-inherited pyridoxine-responsive sideroblastic anemia. Am J Hematol. 1999 Oct;62(2):112-4. - Pubmed
  • Shoolingin-Jordan PM, Al-Daihan S, Alexeev D, Baxter RL, Bottomley SS, Kahari ID, Roy I, Sarwar M, Sawyer L, Wang SF: 5-Aminolevulinic acid synthase: mechanism, mutations and medicine. Biochim Biophys Acta. 2003 Apr 11;1647(1-2):361-6. - Pubmed
DTHybrid score 0.8521
Serine--pyruvate aminotransferase
Name Serine--pyruvate aminotransferase
Gene Name AGXT
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Coulter-Mackie MB, Lian Q: Consequences of missense mutations for dimerization and turnover of alanine:glyoxylate aminotransferase: study of a spectrum of mutations. Mol Genet Metab. 2006 Dec;89(4):349-59. Epub 2006 Sep 12. - Pubmed
DTHybrid score 1.615
Pyridoxal phosphate phosphatase
Name Pyridoxal phosphate phosphatase
Gene Name PDXP
Pharmacological action unknown
Actions cofactor
References
  • Jang YM, Kim DW, Kang TC, Won MH, Baek NI, Moon BJ, Choi SY, Kwon OS: Human pyridoxal phosphatase. Molecular cloning, functional expression, and tissue distribution. J Biol Chem. 2003 Dec 12;278(50):50040-6. Epub 2003 Sep 30. - Pubmed
  • McCarty MF: Increased homocyst(e)ine associated with smoking, chronic inflammation, and aging may reflect acute-phase induction of pyridoxal phosphatase activity. Med Hypotheses. 2000 Oct;55(4):289-93. - Pubmed
  • Hwang IK, Yoo KY, Kim do H, Lee BH, Kwon YG, Won MH: Time course of changes in pyridoxal 5'-phosphate (vitamin B6 active form) and its neuroprotection in experimental ischemic damage. Exp Neurol. 2007 Jul;206(1):114-25. Epub 2007 Apr 24. - Pubmed
  • Kim DW, Eum WS, Choi HS, Kim SY, An JJ, Lee SH, Sohn EJ, Hwang SI, Kwon OS, Kang TC, Won MH, Cho SW, Lee KS, Park J, Choi SY: Human brain pyridoxal-5'-phosphate phosphatase: production and characterization of monoclonal antibodies. J Biochem Mol Biol. 2005 Nov 30;38(6):703-8. - Pubmed
  • Tirrell IM, Wall JL, Daley CJ, Denial SJ, Tennis FG, Galens KG, O'Handley SF: YZGD from Paenibacillus thiaminolyticus, a pyridoxal phosphatase of the HAD (haloacid dehalogenase) superfamily and a versatile member of the Nudix (nucleoside diphosphate x) hydrolase superfamily. Biochem J. 2006 Mar 15;394(Pt 3):665-74. - Pubmed
DTHybrid score 0.9382
Serine palmitoyltransferase 1
Name Serine palmitoyltransferase 1
Gene Name SPTLC1
Pharmacological action unknown
Actions cofactor
References
  • Hanada K: Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism. Biochim Biophys Acta. 2003 Jun 10;1632(1-3):16-30. - Pubmed
  • Gable K, Han G, Monaghan E, Bacikova D, Natarajan M, Williams R, Dunn TM: Mutations in the yeast LCB1 and LCB2 genes, including those corresponding to the hereditary sensory neuropathy type I mutations, dominantly inactivate serine palmitoyltransferase. J Biol Chem. 2002 Mar 22;277(12):10194-200. Epub 2002 Jan 7. - Pubmed
  • Ikushiro H, Hayashi H, Kagamiyama H: A water-soluble homodimeric serine palmitoyltransferase from Sphingomonas paucimobilis EY2395T strain. Purification, characterization, cloning, and overproduction. J Biol Chem. 2001 May 25;276(21):18249-56. Epub 2001 Mar 12. - Pubmed
DTHybrid score 1.126
Cystathionine gamma-lyase
Name Cystathionine gamma-lyase
Gene Name CTH
Pharmacological action unknown
Actions cofactor
References
  • Yamagata S, Akamatsu T, Iwama T: Immobilization of Saccharomyces cerevisiae cystathionine gamma-lyase and application of the product to cystathionine synthesis. Appl Environ Microbiol. 2004 Jun;70(6):3766-8. - Pubmed
  • Bertoldi M, Cellini B, Laurents DV, Borri Voltattorni C: Folding pathway of the pyridoxal 5'-phosphate C-S lyase MalY from Escherichia coli. Biochem J. 2005 Aug 1;389(Pt 3):885-98. - Pubmed
  • Lowicka E, Beltowski J: Hydrogen sulfide (H2S) - the third gas of interest for pharmacologists. Pharmacol Rep. 2007 Jan-Feb;59(1):4-24. - Pubmed
  • Lima CP, Davis SR, Mackey AD, Scheer JB, Williamson J, Gregory JF 3rd: Vitamin B-6 deficiency suppresses the hepatic transsulfuration pathway but increases glutathione concentration in rats fed AIN-76A or AIN-93G diets. J Nutr. 2006 Aug;136(8):2141-7. - Pubmed
  • Okuno T, Kubota T, Kuroda T, Ueno H, Nakamuro K: Contribution of enzymic alpha, gamma-elimination reaction in detoxification pathway of selenomethionine in mouse liver. Toxicol Appl Pharmacol. 2001 Oct 1;176(1):18-23. - Pubmed
DTHybrid score 1.4938
Branched-chain-amino-acid aminotransferase, cytosolic
Name Branched-chain-amino-acid aminotransferase, cytosolic
Gene Name BCAT1
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.963
Branched-chain-amino-acid aminotransferase, mitochondrial
Name Branched-chain-amino-acid aminotransferase, mitochondrial
Gene Name BCAT2
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9877
Proline synthetase co-transcribed bacterial homolog protein
Name Proline synthetase co-transcribed bacterial homolog protein
Gene Name PROSC
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7324
Formimidoyltransferase-cyclodeaminase
Name Formimidoyltransferase-cyclodeaminase
Gene Name FTCD
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8407
Aspartate aminotransferase, mitochondrial
Name Aspartate aminotransferase, mitochondrial
Gene Name GOT2
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Mavrides C, Orr W: Multispecific aspartate and aromatic amino acid aminotransferases in Escherichia coli. J Biol Chem. 1975 Jun 10;250(11):4128-33. - Pubmed
DTHybrid score 0.8988
Glycogen phosphorylase, brain form
Name Glycogen phosphorylase, brain form
Gene Name PYGB
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9439
Glycogen phosphorylase, muscle form
Name Glycogen phosphorylase, muscle form
Gene Name PYGM
Pharmacological action unknown
Actions cofactor
References
  • Livanova NB, Chebotareva NA, Eronina TB, Kurganov BI: Pyridoxal 5'-phosphate as a catalytic and conformational cofactor of muscle glycogen phosphorylase B. Biochemistry (Mosc). 2002 Oct;67(10):1089-98. - Pubmed
  • Kurganov BI, Kornilaev BA, Chebotareva NA, Malikov VP, Orlov VN, Lyubarev AE, Livanova NB: Dissociative mechanism of thermal denaturation of rabbit skeletal muscle glycogen phosphorylase b. Biochemistry. 2000 Oct 31;39(43):13144-52. - Pubmed
  • Okada M, Shibuya M, Yamamoto E, Murakami Y: Effect of diabetes on vitamin B6 requirement in experimental animals. Diabetes Obes Metab. 1999 Jul;1(4):221-5. - Pubmed
  • Okada M, Goda H, Kondo Y, Murakami Y, Shibuya M: Effect of exercise on the metabolism of vitamin B6 and some PLP-dependent enzymes in young rats fed a restricted vitamin B6 diet. J Nutr Sci Vitaminol (Tokyo). 2001 Apr;47(2):116-21. - Pubmed
  • Geremia S, Campagnolo M, Schinzel R, Johnson LN: Enzymatic catalysis in crystals of Escherichia coli maltodextrin phosphorylase. J Mol Biol. 2002 Sep 13;322(2):413-23. - Pubmed
DTHybrid score 2.0248
Aromatic-L-amino-acid decarboxylase
Name Aromatic-L-amino-acid decarboxylase
Gene Name DDC
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Rahman MK, Nagatsu T, Sakurai T, Hori S, Abe M, Matsuda M: Effect of pyridoxal phosphate deficiency on aromatic L-amino acid decarboxylase activity with L-DOPA and L-5-hydroxytryptophan as substrates in rats. Jpn J Pharmacol. 1982 Oct;32(5):803-11. - Pubmed
  • Rorsman F, Husebye ES, Winqvist O, Bjork E, Karlsson FA, Kampe O: Aromatic-L-amino-acid decarboxylase, a pyridoxal phosphate-dependent enzyme, is a beta-cell autoantigen. Proc Natl Acad Sci U S A. 1995 Sep 12;92(19):8626-9. - Pubmed
  • Bertoldi M, Borri Voltattorni C: Reaction of dopa decarboxylase with L-aromatic amino acids under aerobic and anaerobic conditions. Biochem J. 2000 Dec 1;352 Pt 2:533-8. - Pubmed
  • Allen GF, Neergheen V, Oppenheim M, Fitzgerald JC, Footitt E, Hyland K, Clayton PT, Land JM, Heales SJ: Pyridoxal 5'-phosphate deficiency causes a loss of aromatic L-amino acid decarboxylase in patients and human neuroblastoma cells, implications for aromatic L-amino acid decarboxylase and vitamin B(6) deficiency states. J Neurochem. 2010 Jul;114(1):87-96. Epub 2010 Apr 9. - Pubmed
DTHybrid score 0.8226
Serine hydroxymethyltransferase, mitochondrial
Name Serine hydroxymethyltransferase, mitochondrial
Gene Name SHMT2
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Trakatellis A, Dimitriadou A, Exindari M, Christodoulou D, Malissiovas N, Antoniadis A, Haitoglou K: Effect of combination of deoxypyridoxine with known anti-proliferative or immunosuppressive agents on lymphocyte serine hydroxymethyltransferase. Postgrad Med J. 1994;70 Suppl 1:S89-92. - Pubmed
  • Jagath JR, Sharma B, Rao NA, Savithri HS: The role of His-134, -147, and -150 residues in subunit assembly, cofactor binding, and catalysis of sheep liver cytosolic serine hydroxymethyltransferase. J Biol Chem. 1997 Sep 26;272(39):24355-62. - Pubmed
  • Bourguignon J, Neuburger M, Douce R: Resolution and characterization of the glycine-cleavage reaction in pea leaf mitochondria. Properties of the forward reaction catalysed by glycine decarboxylase and serine hydroxymethyltransferase. Biochem J. 1988 Oct 1;255(1):169-78. - Pubmed
DTHybrid score 0.921
Growth-inhibiting protein 18
Name Growth-inhibiting protein 18
Gene Name GIG18
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7317
GAD1 protein
Name GAD1 protein
Gene Name GAD1
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Bennett CL, Huynh HM, Chance PF, Glass IA, Gospe SM Jr: Genetic heterogeneity for autosomal recessive pyridoxine-dependent seizures. Neurogenetics. 2005 Sep;6(3):143-9. Epub 2005 Aug 2. - Pubmed
  • Vassort C, Riviere M, Bruneau G, Gros F, Thibault J, Levan G, Szpirer J, Szpirer C: Assignment of the rat genes coding for dopa decarboxylase (DDC) and glutamic acid decarboxylases (GAD1 and GAD2). Mamm Genome. 1993;4(4):202-6. - Pubmed
  • Cormier-Daire V, Dagoneau N, Nabbout R, Burglen L, Penet C, Soufflet C, Desguerre I, Munnich A, Dulac O: A gene for pyridoxine-dependent epilepsy maps to chromosome 5q31. Am J Hum Genet. 2000 Oct;67(4):991-3. Epub 2000 Sep 7. - Pubmed
DTHybrid score 0.944
Serine hydroxymethyltransferase 2
Name Serine hydroxymethyltransferase 2
Gene Name Not Available
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Mehta R, Shangari N, O'brien PJ: Preventing cell death induced by carbonyl stress, oxidative stress or mitochondrial toxins with vitamin B anti-AGE agents. Mol Nutr Food Res. 2007 Oct 4;. - Pubmed
DTHybrid score 0.9209
Serine hydroxymethyltransferase 1
Name Serine hydroxymethyltransferase 1
Gene Name Not Available
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Bayes M, Rabasseda X, Prous JR: Gateways to clinical trials. Methods Find Exp Clin Pharmacol. 2007 Jun;29(5):359-73. - Pubmed
  • Bleie O, Semb AG, Grundt H, Nordrehaug JE, Vollset SE, Ueland PM, Nilsen DW, Bakken AM, Refsum H, Nygard OK: Homocysteine-lowering therapy does not affect inflammatory markers of atherosclerosis in patients with stable coronary artery disease. J Intern Med. 2007 Aug;262(2):244-53. - Pubmed
DTHybrid score 0.9407
Selenocysteine lyase variant
Name Selenocysteine lyase variant
Gene Name Not Available
Pharmacological action unknown
Actions cofactor
References
  • Heidenreich T, Wollers S, Mendel RR, Bittner F: Characterization of the NifS-like domain of ABA3 from Arabidopsis thaliana provides insight into the mechanism of molybdenum cofactor sulfuration. J Biol Chem. 2005 Feb 11;280(6):4213-8. Epub 2004 Nov 22. - Pubmed
DTHybrid score 0.9383
Brain glycogen phosphorylase variant
Name Brain glycogen phosphorylase variant
Gene Name Not Available
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9438
Ornithine aminotransferase variant
Name Ornithine aminotransferase variant
Gene Name Not Available
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9392
SHMT2 protein
Name SHMT2 protein
Gene Name SHMT2
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9158
Hypothetical protein DKFZp686P09201
Name Hypothetical protein DKFZp686P09201
Gene Name DKFZp686P09201
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9207
Migration-inducing protein 4
Name Migration-inducing protein 4
Gene Name ALAS1
Pharmacological action unknown
Actions cofactor
References
  • Ferreira GC, Zhang JS: Mechanism of 5-aminolevulinate synthase and the role of the protein environment in controlling the cofactor chemistry. Cell Mol Biol (Noisy-le-grand). 2002 Dec;48(8):827-33. - Pubmed
  • Choi HP, Hong JW, Rhee KH, Sung HC: Cloning, expression, and characterization of 5-aminolevulinic acid synthase from Rhodopseudomonas palustris KUGB306. FEMS Microbiol Lett. 2004 Jul 15;236(2):175-81. - Pubmed
  • Zhang J, Ferreira GC: Transient state kinetic investigation of 5-aminolevulinate synthase reaction mechanism. J Biol Chem. 2002 Nov 22;277(47):44660-9. Epub 2002 Aug 20. - Pubmed
  • Turbeville TD, Zhang J, Hunter GA, Ferreira GC: Histidine 282 in 5-aminolevulinate synthase affects substrate binding and catalysis. Biochemistry. 2007 May 22;46(20):5972-81. Epub 2007 May 1. - Pubmed
  • Zhang J, Cheltsov AV, Ferreira GC: Conversion of 5-aminolevulinate synthase into a more active enzyme by linking the two subunits: spectroscopic and kinetic properties. Protein Sci. 2005 May;14(5):1190-200. - Pubmed
DTHybrid score 0.9411
Phosphorylase
Name Phosphorylase
Gene Name PYGB
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9423
Glutamate decarboxylase 2
Name Glutamate decarboxylase 2
Gene Name GAD2
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Bennett CL, Huynh HM, Chance PF, Glass IA, Gospe SM Jr: Genetic heterogeneity for autosomal recessive pyridoxine-dependent seizures. Neurogenetics. 2005 Sep;6(3):143-9. Epub 2005 Aug 2. - Pubmed
  • Vassort C, Riviere M, Bruneau G, Gros F, Thibault J, Levan G, Szpirer J, Szpirer C: Assignment of the rat genes coding for dopa decarboxylase (DDC) and glutamic acid decarboxylases (GAD1 and GAD2). Mamm Genome. 1993;4(4):202-6. - Pubmed
  • Cormier-Daire V, Dagoneau N, Nabbout R, Burglen L, Penet C, Soufflet C, Desguerre I, Munnich A, Dulac O: A gene for pyridoxine-dependent epilepsy maps to chromosome 5q31. Am J Hum Genet. 2000 Oct;67(4):991-3. Epub 2000 Sep 7. - Pubmed
DTHybrid score 0.0976
Putative L-Dopa decarboxylase
Name Putative L-Dopa decarboxylase
Gene Name DDC
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9422
DDC protein
Name DDC protein
Gene Name DDC
Pharmacological action unknown
Actions cofactor
References
  • Tan EK, Cheah SY, Fook-Chong S, Yew K, Chandran VR, Lum SY, Yi Z: Functional COMT variant predicts response to high dose pyridoxine in Parkinson's disease. Am J Med Genet B Neuropsychiatr Genet. 2005 Aug 5;137(1):1-4. - Pubmed
  • Bertoldi M, Borri Voltattorni C: Reaction of dopa decarboxylase with L-aromatic amino acids under aerobic and anaerobic conditions. Biochem J. 2000 Dec 1;352 Pt 2:533-8. - Pubmed
  • Yee RE, Cheng DW, Huang SC, Namavari M, Satyamurthy N, Barrio JR: Blood-brain barrier and neuronal membrane transport of 6-[18F]fluoro-L-DOPA. Biochem Pharmacol. 2001 Nov 15;62(10):1409-15. - Pubmed
  • Skoldberg F, Portela-Gomes GM, Grimelius L, Nilsson G, Perheentupa J, Betterle C, Husebye ES, Gustafsson J, Ronnblom A, Rorsman F, Kampe O: Histidine decarboxylase, a pyridoxal phosphate-dependent enzyme, is an autoantigen of gastric enterochromaffin-like cells. J Clin Endocrinol Metab. 2003 Apr;88(4):1445-52. - Pubmed
  • Skoldberg F, Rorsman F, Perheentupa J, Landin-Olsson M, Husebye ES, Gustafsson J, Kampe O: Analysis of antibody reactivity against cysteine sulfinic acid decarboxylase, a pyridoxal phosphate-dependent enzyme, in endocrine autoimmune disease. J Clin Endocrinol Metab. 2004 Apr;89(4):1636-40. - Pubmed
DTHybrid score 0.942
KIAA0251 protein
Name KIAA0251 protein
Gene Name PDXDC1
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9375
Kynurenine--oxoglutarate transaminase 3
Name Kynurenine--oxoglutarate transaminase 3
Gene Name CCBL2
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7819
CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase
Name CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase
Gene Name GADL1
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9395
Selenocysteine lyase
Name Selenocysteine lyase
Gene Name SCLY
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
Immunoglobulin superfamily member 10
Name Immunoglobulin superfamily member 10
Gene Name IGSF10
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
Alanine--glyoxylate aminotransferase 2-like 2
Name Alanine--glyoxylate aminotransferase 2-like 2
Gene Name AGXT2L2
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9337
Glutamate decarboxylase 1
Name Glutamate decarboxylase 1
Gene Name GAD1
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Bennett CL, Huynh HM, Chance PF, Glass IA, Gospe SM Jr: Genetic heterogeneity for autosomal recessive pyridoxine-dependent seizures. Neurogenetics. 2005 Sep;6(3):143-9. Epub 2005 Aug 2. - Pubmed
  • Vassort C, Riviere M, Bruneau G, Gros F, Thibault J, Levan G, Szpirer J, Szpirer C: Assignment of the rat genes coding for dopa decarboxylase (DDC) and glutamic acid decarboxylases (GAD1 and GAD2). Mamm Genome. 1993;4(4):202-6. - Pubmed
  • Cormier-Daire V, Dagoneau N, Nabbout R, Burglen L, Penet C, Soufflet C, Desguerre I, Munnich A, Dulac O: A gene for pyridoxine-dependent epilepsy maps to chromosome 5q31. Am J Hum Genet. 2000 Oct;67(4):991-3. Epub 2000 Sep 7. - Pubmed
DTHybrid score 0.7902
SHMT2 protein
Name SHMT2 protein
Gene Name SHMT2
Pharmacological action unknown
Actions cofactor
References
  • Bhavani S, Trivedi V, Jala VR, Subramanya HS, Kaul P, Prakash V, Appaji Rao N, Savithri HS: Role of Lys-226 in the catalytic mechanism of Bacillus stearothermophilus serine hydroxymethyltransferase--crystal structure and kinetic studies. Biochemistry. 2005 May 10;44(18):6929-37. - Pubmed
  • Trivedi V, Gupta A, Jala VR, Saravanan P, Rao GS, Rao NA, Savithri HS, Subramanya HS: Crystal structure of binary and ternary complexes of serine hydroxymethyltransferase from Bacillus stearothermophilus: insights into the catalytic mechanism. J Biol Chem. 2002 May 10;277(19):17161-9. Epub 2002 Feb 27. - Pubmed
  • Perry C, Yu S, Chen J, Matharu KS, Stover PJ: Effect of vitamin B6 availability on serine hydroxymethyltransferase in MCF-7 cells. Arch Biochem Biophys. 2007 Jun 1;462(1):21-7. Epub 2007 Apr 20. - Pubmed
  • Rajaram V, Bhavani BS, Kaul P, Prakash V, Appaji Rao N, Savithri HS, Murthy MR: Structure determination and biochemical studies on Bacillus stearothermophilus E53Q serine hydroxymethyltransferase and its complexes provide insights on function and enzyme memory. FEBS J. 2007 Aug;274(16):4148-60. Epub 2007 Jul 25. - Pubmed
  • Mukherjee M, Sievers SA, Brown MT, Johnson PJ: Identification and biochemical characterization of serine hydroxymethyl transferase in the hydrogenosome of Trichomonas vaginalis. Eukaryot Cell. 2006 Dec;5(12):2072-8. Epub 2006 Sep 15. - Pubmed
DTHybrid score 0.9158
Aminolevulinate, delta-, synthase 2
Name Aminolevulinate, delta-, synthase 2
Gene Name ALAS2
Pharmacological action unknown
Actions cofactor
References
  • Shoolingin-Jordan PM, Al-Daihan S, Alexeev D, Baxter RL, Bottomley SS, Kahari ID, Roy I, Sarwar M, Sawyer L, Wang SF: 5-Aminolevulinic acid synthase: mechanism, mutations and medicine. Biochim Biophys Acta. 2003 Apr 11;1647(1-2):361-6. - Pubmed
  • Choi HP, Hong JW, Rhee KH, Sung HC: Cloning, expression, and characterization of 5-aminolevulinic acid synthase from Rhodopseudomonas palustris KUGB306. FEMS Microbiol Lett. 2004 Jul 15;236(2):175-81. - Pubmed
  • Heller T, Hochstetter V, Basler M, Borck V: [Vitamin B6-sensitive hereditary sideroblastic anemia] Dtsch Med Wochenschr. 2004 Jan 23;129(4):141-4. - Pubmed
  • Clayton PT: B6-responsive disorders: a model of vitamin dependency. J Inherit Metab Dis. 2006 Apr-Jun;29(2-3):317-26. - Pubmed
  • Astner I, Schulze JO, van den Heuvel J, Jahn D, Schubert WD, Heinz DW: Crystal structure of 5-aminolevulinate synthase, the first enzyme of heme biosynthesis, and its link to XLSA in humans. EMBO J. 2005 Sep 21;24(18):3166-77. Epub 2005 Aug 25. - Pubmed
DTHybrid score 0.9394
Alanine aminotransferase 2
Name Alanine aminotransferase 2
Gene Name GPT2
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Welch S: Comparative studies on the human glutamate-pyruvate transaminase phenotypes--GPT 1, GPT 2-1, GPT 2. Humangenetik. 1975 Sep 20;30(3):237-49. - Pubmed
DTHybrid score 0.9241
Molybdenum cofactor sulfurase
Name Molybdenum cofactor sulfurase
Gene Name MOCOS
Pharmacological action unknown
Actions cofactor
References
  • Heidenreich T, Wollers S, Mendel RR, Bittner F: Characterization of the NifS-like domain of ABA3 from Arabidopsis thaliana provides insight into the mechanism of molybdenum cofactor sulfuration. J Biol Chem. 2005 Feb 11;280(6):4213-8. Epub 2004 Nov 22. - Pubmed
  • Mendel RR, Bittner F: Cell biology of molybdenum. Biochim Biophys Acta. 2006 Jul;1763(7):621-35. Epub 2006 May 12. - Pubmed
  • Anantharaman V, Aravind L: MOSC domains: ancient, predicted sulfur-carrier domains, present in diverse metal-sulfur cluster biosynthesis proteins including Molybdenum cofactor sulfurases. FEMS Microbiol Lett. 2002 Jan 22;207(1):55-61. - Pubmed
  • Bittner F, Oreb M, Mendel RR: ABA3 is a molybdenum cofactor sulfurase required for activation of aldehyde oxidase and xanthine dehydrogenase in Arabidopsis thaliana. J Biol Chem. 2001 Nov 2;276(44):40381-4. Epub 2001 Sep 11. - Pubmed
DTHybrid score 0.9374
Serine dehydratase-like
Name Serine dehydratase-like
Gene Name SDSL
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9383
P-selectin cytoplasmic tail-associated protein
Name P-selectin cytoplasmic tail-associated protein
Gene Name pcap
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9411
Hepatic peroxysomal alanine:glyoxylate aminotransferase
Name Hepatic peroxysomal alanine:glyoxylate aminotransferase
Gene Name Not Available
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9401
Serine racemase
Name Serine racemase
Gene Name SRR
Pharmacological action unknown
Actions cofactor
References
  • Hashimoto A, Yoshikawa M: Effect of aminooxyacetic acid on extracellular level of D-serine in rat striatum: an in vivo microdialysis study. Eur J Pharmacol. 2005 Nov 21;525(1-3):91-3. Epub 2005 Nov 14. - Pubmed
  • Strisovsky K, Jiraskova J, Mikulova A, Rulisek L, Konvalinka J: Dual substrate and reaction specificity in mouse serine racemase: identification of high-affinity dicarboxylate substrate and inhibitors and analysis of the beta-eliminase activity. Biochemistry. 2005 Oct 4;44(39):13091-100. - Pubmed
  • Schell MJ: The N-methyl D-aspartate receptor glycine site and D-serine metabolism: an evolutionary perspective. Philos Trans R Soc Lond B Biol Sci. 2004 Jun 29;359(1446):943-64. - Pubmed
  • Strisovsky K, Jiraskova J, Barinka C, Majer P, Rojas C, Slusher BS, Konvalinka J: Mouse brain serine racemase catalyzes specific elimination of L-serine to pyruvate. FEBS Lett. 2003 Jan 30;535(1-3):44-8. - Pubmed
  • Uo T, Yoshimura T, Nishiyama T, Esaki N: Gene cloning, purification, and characterization of 2,3-diaminopropionate ammonia-lyase from Escherichia coli. Biosci Biotechnol Biochem. 2002 Dec;66(12):2639-44. - Pubmed
DTHybrid score 1.1264
O-phosphoseryl-tRNA(Sec) selenium transferase
Name O-phosphoseryl-tRNA(Sec) selenium transferase
Gene Name SEPSECS
Pharmacological action unknown
Actions cofactor
References
  • Xu XM, Carlson BA, Mix H, Zhang Y, Saira K, Glass RS, Berry MJ, Gladyshev VN, Hatfield DL: Biosynthesis of selenocysteine on its tRNA in eukaryotes. PLoS Biol. 2007 Jan;5(1):e4. - Pubmed
  • Kernebeck T, Lohse AW, Grotzinger J: A bioinformatical approach suggests the function of the autoimmune hepatitis target antigen soluble liver antigen/liver pancreas. Hepatology. 2001 Aug;34(2):230-3. - Pubmed
DTHybrid score 0.9378
Uncharacterized protein C20orf38
Name Uncharacterized protein C20orf38
Gene Name SPTLC3
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9386
Glutamic acid decarboxylase
Name Glutamic acid decarboxylase
Gene Name GAD65
Pharmacological action unknown
Actions cofactor
References
  • Tong JC, Myers MA, Mackay IR, Zimmet PZ, Rowley MJ: The PEVKEK region of the pyridoxal phosphate binding domain of GAD65 expresses a dominant B cell epitope for type 1 diabetes sera. Ann N Y Acad Sci. 2002 Apr;958:182-9. - Pubmed
  • Burd L, Stenehjem A, Franceschini LA, Kerbeshian J: A 15-year follow-up of a boy with pyridoxine (vitamin B6)-dependent seizures with autism, breath holding, and severe mental retardation. J Child Neurol. 2000 Nov;15(11):763-5. - Pubmed
  • Myers MA, Davies JM, Tong JC, Whisstock J, Scealy M, Mackay IR, Rowley MJ: Conformational epitopes on the diabetes autoantigen GAD65 identified by peptide phage display and molecular modeling. J Immunol. 2000 Oct 1;165(7):3830-8. - Pubmed
  • Gospe SM Jr: Pyridoxine-dependent seizures: new genetic and biochemical clues to help with diagnosis and treatment. Curr Opin Neurol. 2006 Apr;19(2):148-53. - Pubmed
  • Hwang IK, Yoo KY, Kim do H, Lee BH, Kwon YG, Won MH: Time course of changes in pyridoxal 5'-phosphate (vitamin B6 active form) and its neuroprotection in experimental ischemic damage. Exp Neurol. 2007 Jul;206(1):114-25. Epub 2007 Apr 24. - Pubmed
DTHybrid score 0.8404
Alanine-glyoxylate aminotransferase homolog
Name Alanine-glyoxylate aminotransferase homolog
Gene Name TLH6
Pharmacological action unknown
Actions cofactor
References
  • Nishijima S, Sugaya K, Morozumi M, Hatano T, Ogawa Y: Hepatic alanine-glyoxylate aminotransferase activity and oxalate metabolism in vitamin B6 deficient rats. J Urol. 2003 Feb;169(2):683-6. - Pubmed
  • Gable K, Han G, Monaghan E, Bacikova D, Natarajan M, Williams R, Dunn TM: Mutations in the yeast LCB1 and LCB2 genes, including those corresponding to the hereditary sensory neuropathy type I mutations, dominantly inactivate serine palmitoyltransferase. J Biol Chem. 2002 Mar 22;277(12):10194-200. Epub 2002 Jan 7. - Pubmed
  • Nishijima S, Sugaya K, Morozumi M, Hatano T, Ogawa Y: Capillary electrophoresis assay of alanine:glyoxylate aminotransferase activity in rat liver. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Nov 15;780(1):13-9. - Pubmed
  • Nishijima S, Sugaya K, Hokama S, Oshiro Y, Uchida A, Morozumi M, Ogawa Y: Effect of vitamin B6 deficiency on glyoxylate metabolism in rats with or without glyoxylate overload. Biomed Res. 2006 Jun;27(3):93-8. - Pubmed
  • Danpure CJ, Lumb MJ, Birdsey GM, Zhang X: Alanine:glyoxylate aminotransferase peroxisome-to-mitochondrion mistargeting in human hereditary kidney stone disease. Biochim Biophys Acta. 2003 Apr 11;1647(1-2):70-5. - Pubmed
DTHybrid score 0.9398
Cysteine sulfinic acid decarboxylase-related protein 1
Name Cysteine sulfinic acid decarboxylase-related protein 1
Gene Name CSAD
Pharmacological action unknown
Actions cofactor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Skoldberg F, Rorsman F, Perheentupa J, Landin-Olsson M, Husebye ES, Gustafsson J, Kampe O: Analysis of antibody reactivity against cysteine sulfinic acid decarboxylase, a pyridoxal phosphate-dependent enzyme, in endocrine autoimmune disease. J Clin Endocrinol Metab. 2004 Apr;89(4):1636-40. - Pubmed
DTHybrid score 0.94

Predictions


Id Partner name Gene Name Score
4654 Kynureninase kynU 1.3631
6151 Monocarboxylate transporter 10 SLC16A10 0.9889
4652 Phosphoserine aminotransferase serC 0.782
5493 Tyrosine aminotransferase Not Available 0.7635
72 Seryl-tRNA synthetase, cytoplasmic SARS 0.4719
593 Proton-coupled amino acid transporter 1 SLC36A1 0.3133
2842 Glutamate-1-semialdehyde 2,1-aminomutase hemL 0.2651
532 Neutral amino acid transporter A SLC1A4 0.2638
323 Alanyl-tRNA synthetase, cytoplasmic AARS 0.2637
4070 Probable alanyl-tRNA synthetase, mitochondrial AARS2 0.2637
2746 4-aminobutyrate aminotransferase gabT 0.2472
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.2409
207 Glutathione synthetase GSS 0.2236
5269 Glutathione synthetase gshB 0.2236
2803 Pyridoxine 5'-phosphate synthase pdxJ 0.2207
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.217
4823 L-allo-threonine aldolase TM_1744 0.1961
4069 Threonyl-tRNA synthetase, mitochondrial TARS2 0.1941
261 Threonyl-tRNA synthetase, cytoplasmic TARS 0.1941
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.1893
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.178
3763 5,10-methylenetetrahydrofolate reductase metF 0.1779
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.1779
5094 5,10-methylenetetrahydrofolate reductase metF 0.1779
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.1778
59 AMT protein AMT 0.1778
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.1777
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.1748
1088 5-aminolevulinate synthase, erythroid-specific, mitochondrial ALAS2 0.1702
4059 Glycine N-acyltransferase-like protein 1 GLYATL1 0.169
4057 Glycine N-acyltransferase GLYAT 0.169
4058 Glycine N-acyltransferase-like protein 2 GLYATL2 0.169
4061 Peroxisomal sarcosine oxidase PIPOX 0.169
4056 N-arachidonyl glycine receptor GPR18 0.169
4055 Bile acid CoA:amino acid N-acyltransferase BAAT 0.169
4062 Sodium- and chloride-dependent glycine transporter 2 SLC6A5 0.169
1466 Glycyl-tRNA synthetase GARS 0.1689
4060 Vesicular inhibitory amino acid transporter SLC32A1 0.1689
1236 Sodium- and chloride-dependent glycine transporter 1 SLC6A9 0.1689
171 Cysteine dioxygenase CDO-1 0.1645
1314 Thiamine transporter 2 SLC19A3 0.1641
4064 Probable cysteinyl-tRNA synthetase, mitochondrial CARS2 0.1641
774 Cysteinyl-tRNA synthetase, cytoplasmic CARS 0.164
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.1636
815 Histidyl-tRNA synthetase, cytoplasmic HARS 0.1621
96 Histidine ammonia-lyase HAL 0.1621
6257 Histidine ammonia-lyase Not Available 0.1621
6536 Histidine ammonia-lyase hutH 0.1621
2748 Cysteine desulfurase sufS 0.1593
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.15
411 Glycine N-methyltransferase GNMT 0.1478
3470 Hypothetical protein MG245 homolog MPN_348 0.1428
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.14
13 Aminomethyltransferase, mitochondrial AMT 0.1339
383 Glycine amidinotransferase, mitochondrial GATM 0.1328
62 Glycine receptor subunit beta GLRB 0.1302
1999 Methylated-DNA--protein-cysteine methyltransferase MGMT 0.1302
199 Monocarboxylate transporter 8 SLC16A2 0.1301
626 Cysteine dioxygenase type 1 CDO1 0.127
4054 Glycine cleavage system H protein, mitochondrial GCSH 0.1223
314 System N amino acid transporter 1 SLC38A3 0.121
809 Methionine synthase MTR 0.1168
2935 Methionine synthase metH 0.1168
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.1149
1671 Excitatory amino acid transporter 3 SLC1A1 0.1143
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.1077
820 Glycine receptor subunit alpha-2 GLRA2 0.1062
461 Glycine receptor subunit alpha-3 GLRA3 0.1062
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.1038
3917 Methylenetetrahydrofolate reductase MTHFR 0.0996
2249 Aspartate aminotransferase aspC 0.0982
2671 Aspartate aminotransferase aspC 0.0982
5490 Aspartate aminotransferase Not Available 0.0982
664 Glutamate decarboxylase 2 GAD2 0.0976
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0969
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0969
4026 Aspartyl aminopeptidase DNPEP 0.0969
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0969
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0969
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0969
4019 Excitatory amino acid transporter 4 SLC1A6 0.0969
1912 Excitatory amino acid transporter 1 SLC1A3 0.0969
4016 Excitatory amino acid transporter 5 SLC1A7 0.0969
1047 Excitatory amino acid transporter 2 SLC1A2 0.0969
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0968
922 Glutamate receptor 4 GRIA4 0.0968
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0968
925 Metabotropic glutamate receptor 4 GRM4 0.0968
926 Metabotropic glutamate receptor 7 GRM7 0.0968
4018 Glutamate receptor delta-2 subunit GRID2 0.0968
927 Metabotropic glutamate receptor 8 GRM8 0.0968
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0968
4027 Glutamate receptor delta-1 subunit GRID1 0.0968
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0968
4020 Glutamyl aminopeptidase ENPEP 0.0968
4017 5-oxoprolinase OPLAH 0.0968
5492 Cystathionine gamma-synthase metB 0.0948
5491 Methionine gamma-lyase mdeA 0.0948
1483 Membrane copper amine oxidase AOC3 0.0936
3193 Serine hydroxymethyltransferase glyA 0.0922
3342 Serine hydroxymethyltransferase glyA 0.0922
482 Glycine receptor subunit alpha-1 GLRA1 0.0897
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0896
5 Glutaminase liver isoform, mitochondrial GLS2 0.0896
917 Glutaminase kidney isoform, mitochondrial GLS 0.0896
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0896
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0896
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0896
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0896
5261 Phosphoribosylformylglycinamidine synthase purL 0.0896
738 Monocarboxylate transporter 1 SLC16A1 0.088
6269 S-phase kinase-associated protein 1 SKP1 0.0873
676 Tyrosine 3-monooxygenase TH 0.0862
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0832
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0831
740 Argininosuccinate synthase ASS1 0.0806
865 Argininosuccinate synthase ASS1 0.0806
2680 Argininosuccinate synthase argG 0.0806
3194 Argininosuccinate synthase argG 0.0806
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0797
701 Isoleucine-tRNA synthetase IARS 0.0785
4080 Isoleucyl-tRNA synthetase, mitochondrial IARS2 0.0785
546 Isoleucyl-tRNA synthetase, cytoplasmic IARS 0.0784
399 Tyrosyl-tRNA synthetase, mitochondrial YARS2 0.0782
3082 Aminomethyltransferase gcvT 0.0762
1566 Corticoliberin CRH 0.0759
625 Glutamate carboxypeptidase 2 FOLH1 0.0757
3257 Bifunctional polymyxin resistance protein arnA arnA 0.075
2758 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase bioA 0.0748
5072 N,N-dimethylglycine oxidase dmg 0.0747
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0743
2429 Putrescine-binding periplasmic protein potF 0.0732
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0728
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.0723
150 Cationic amino acid transporter 3 SLC7A3 0.0723
58 Cationic amino acid transporter 4 SLC7A4 0.0723
834 Arginase-2, mitochondrial ARG2 0.0723
246 Valyl-tRNA synthetase VARS 0.0711
916 Metabotropic glutamate receptor 1 GRM1 0.0702
807 D-alanine--D-alanine ligase A ddlA 0.0692
894 Alanine racemase alr 0.0691
2453 Alanine racemase alr 0.0691
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0691
1649 Small inducible cytokine A2 CCL2 0.069
833 Organic cation/carnitine transporter 1 SLC22A4 0.0688
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0687
3939 Amine oxidase [flavin-containing] B MAOB 0.0685
501 Leucine carboxyl methyltransferase 1 LCMT1 0.0676
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0676
675 Leucine carboxyl methyltransferase 2 LCMT2 0.0676
227 Probable leucyl-tRNA synthetase, mitochondrial LARS2 0.0675
846 Leucyl-tRNA synthetase, cytoplasmic LARS 0.0675
923 Glutamate receptor 3 GRIA3 0.0674
6031 Cytochrome P450 3A43 CYP3A43 0.0672
2744 D-alanine aminotransferase dat 0.0664
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.066
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0647
3766 Pyridoxamine 5'-phosphate oxidase pdxH 0.0639
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0638
3426 Glutamine synthetase glnA 0.0632
3987 Glutamine synthetase GLUL 0.0632
5226 Protein ninB ninB 0.0631
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0626
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0622
279 Tyrosinase TYR 0.0592
31 Phenylalanyl-tRNA synthetase, mitochondrial FARS2 0.0588
42 Phenylalanyl-tRNA synthetase alpha chain FARSA 0.0588
6602 Phenylalanyl-tRNA synthetase alpha chain pheS 0.0588
618 Phenylalanyl-tRNA synthetase beta chain FARSB 0.0588
6603 Phenylalanyl-tRNA synthetase beta chain pheT 0.0588
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0586
6013 Cytochrome P450 2E1 CYP2E1 0.0575
601 Propionyl-CoA carboxylase beta chain, mitochondrial PCCB 0.0573
2749 UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase arnB 0.0573
705 Glutamate receptor 1 GRIA1 0.0573
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0564
3941 Amine oxidase [flavin-containing] A MAOA 0.0564
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0562
3972 Adenylosuccinate synthetase isozyme 2 ADSS 0.0555
33 Cystine/glutamate transporter SLC7A11 0.0555
209 Aspartoacylase ASPA 0.0555
533 Aminoacylase-1 ACY1 0.0555
3969 Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole- succinocarboxamide synthase PAICS 0.0555
3979 Aspartoacylase-2 ACY3 0.0555
799 Aspartyl-tRNA synthetase, cytoplasmic DARS 0.0555
513 Calcium-binding mitochondrial carrier protein Aralar2 SLC25A13 0.0555
305 Mitochondrial aspartate-glutamate carrier protein SLC25A13 0.0555
262 Calcium-binding mitochondrial carrier protein Aralar1 SLC25A12 0.0555
3976 Aspartyl-tRNA synthetase, mitochondrial DARS2 0.0555
1277 Alpha-1-antitrypsin SERPINA1 0.0549
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.054
2546 Histidinol-phosphate aminotransferase hisC 0.053
2698 Histidinol-phosphate aminotransferase hisC 0.053
3971 CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase CAD 0.0524
2826 Glucose--fructose oxidoreductase gfo 0.0518
2823 Trypanothione reductase TPR 0.0494
500 Monocarboxylate transporter 4 SLC16A3 0.0484
256 Tyrosyl-tRNA synthetase, cytoplasmic YARS 0.0483
4549 Endonuclease III HP_0602 0.0482
489 Monocarboxylate transporter 2 SLC16A7 0.0479
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0474
3977 ASRGL1 protein ASRGL1 0.0464
330 Spermidine synthase SRM 0.0463
3038 Spermidine synthase speE 0.0463
577 Argininosuccinate lyase ASL 0.0458
2537 Aromatic-amino-acid aminotransferase tyrB 0.0434
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0427
4924 Cytochrome P450 2C8 CYP2C8 0.0423
828 Phenylalanine-4-hydroxylase PAH 0.0418
3109 Phenylalanine-4-hydroxylase phhA 0.0418
4118 Cytochrome P450 3A5 CYP3A5 0.0417
6107 Cytochrome P450 3A7 CYP3A7 0.0414
3184 3-methyl-2-oxobutanoate hydroxymethyltransferase panB 0.0406
3315 3-methyl-2-oxobutanoate hydroxymethyltransferase panB 0.0406
3179 2-isopropylmalate synthase leuA 0.0406
6016 Cytochrome P450 2C19 CYP2C19 0.0403
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0402
3978 Adenylosuccinate synthetase isozyme 1 ADSSL1 0.0397
921 Glutamate receptor 2 GRIA2 0.0391
218 Monocarboxylate transporter 5 SLC16A4 0.0388
397 Monocarboxylate transporter 3 SLC16A8 0.0388
429 Monocarboxylate transporter 6 SLC16A5 0.0388
195 Monocarboxylate transporter 7 SLC16A6 0.0388
1313 Lactoylglutathione lyase GLO1 0.0387
4085 Peptidyl-prolyl cis-trans isomerase C PPIC 0.0354
4083 Peptidyl-prolyl cis-trans isomerase H PPIH 0.0354
4090 Chromosome 14 open reading frame 149 C14orf149 0.0353
4088 Probable prolyl-tRNA synthetase, mitochondrial PARS2 0.0353
797 Sodium-dependent proline transporter SLC6A7 0.0353
4082 Proline oxidase, mitochondrial PRODH 0.0353
4087 Pyrroline 5-carboxylate reductase isoform P5CR2 0.0353
4086 Peptidyl-prolyl cis-trans isomerase G PPIG 0.0353
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0348
4512 Cytochrome P450 3A4 CYP3A4 0.0339
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0339
3334 Deacetoxycephalosporin C synthetase cefE 0.0329
831 D(2) dopamine receptor DRD2 0.0325
2300 Lysozyme E 0.032
3633 Lysozyme R 0.032
5597 Lysozyme 17 0.032
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0318
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0308
3981 Ornithine decarboxylase antizyme 3 OAZ3 0.0307
3980 Ornithine decarboxylase antizyme 2 OAZ2 0.0307
410 Ornithine decarboxylase antizyme OAZ1 0.0307
224 Mitochondrial ornithine transporter 1 SLC25A15 0.0307
285 Mitochondrial ornithine transporter 2 SLC25A2 0.0307
16 Adenosine A1 receptor ADORA1 0.0297
52 Pyruvate kinase isozymes R/L PKLR 0.0296
771 Pyruvate carboxylase, mitochondrial PC 0.0286
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0281
2503 Phosphomannomutase/phosphoglucomutase algC 0.028
123 Diamine acetyltransferase 1 SAT1 0.0278
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0274
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0271
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0271
303 Diamine acetyltransferase 2 SAT2 0.027
7 Nitric oxide synthase, inducible NOS2 0.027
1317 Spermine synthase SMS 0.027
623 Spermine oxidase SMOX 0.027
4084 Peptidyl-prolyl cis-trans isomerase B PPIB 0.0268
291 Nitric-oxide synthase, endothelial NOS3 0.0267
118 Organic cation/carnitine transporter 2 SLC22A5 0.0265
619 Low-affinity cationic amino acid transporter 2 SLC7A2 0.0261
5682 Ribonuclease pancreatic RNASE1 0.0255
98 Pyruvate kinase isozymes M1/M2 PKM2 0.0252
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.0243
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.0243
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.0243
2554 Peptidyl-prolyl cis-trans isomerase, mitochondrial PPIF 0.0239
336 Ornithine carbamoyltransferase, mitochondrial OTC 0.0239
4063 Tryptophanyl-tRNA synthetase, mitochondrial WARS2 0.0238
90 Tryptophan 5-hydroxylase 2 TPH2 0.0238
3810 Catechol O-methyltransferase COMT 0.0236
23 D(1A) dopamine receptor DRD1 0.0228
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0227
694 Matrix protein 2 M 0.0226
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0224
6145 Solute carrier family 22 member 1 SLC22A1 0.0224
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0212
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0212
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0208
6614 Lactase-like protein LCTL 0.0203
315 Arginase-1 ARG1 0.0202
765 Indoleamine 2,3-dioxygenase IDO1 0.0198
556 Alpha-1A adrenergic receptor ADRA1A 0.0195
252 Tryptophanyl-tRNA synthetase, cytoplasmic WARS 0.0186
1588 Multidrug resistance protein 1 ABCB1 0.0179
134 Tryptophan 5-hydroxylase 1 TPH1 0.0175
6012 Tryptophan 2,3-dioxygenase TDO2 0.0173
2452 Tryptophanyl-tRNA synthetase trpS 0.0173
2514 Phosphocarrier protein HPr ptsH 0.0157
5689 Phosphocarrier protein HPr ptsH 0.0157
3602 Anti-sigma F factor antagonist spoIIAA 0.0157
5686 Potassium voltage-gated channel subfamily C member 4 KCNC4 0.0157
6847 Lactase-phlorizin hydrolase LCT 0.015
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0149
3101 Glucose-1-phosphatase agp 0.0148
3947 Xanthine dehydrogenase/oxidase XDH 0.0147
3091 Maltodextrin phosphorylase malP 0.0147
1130 Lithostathine 1 alpha REG1A 0.0136
4542 Glutaminase 1 glsA1 0.0136
4544 Glutaminase 1 glsA1 0.0136
502 5-hydroxytryptamine 2A receptor HTR2A 0.013
4318 Siroheme synthase cysG 0.0128
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0126
2530 Protein kinase C theta type PRKCQ 0.0125
3119 Fimbrial protein pilE1 0.0125
3453 Alkaline phosphatase phoA 0.0118
6144 Solute carrier family 22 member 2 SLC22A2 0.0115
5150 Endo-1,4-beta-xylanase Y xynY 0.0113
5176 YtnJ moxC 0.0113
1517 Beta-3 adrenergic receptor ADRB3 0.0111
1008 CTP synthase 1 CTPS 0.011
3985 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2 GFPT2 0.011
3990 Protein-glutamine gamma-glutamyltransferase 4 TGM4 0.011
3986 Protein-glutamine gamma-glutamyltransferase 6 TGM6 0.011
3992 Protein-glutamine gamma-glutamyltransferase Z TGM7 0.011
3983 Protein-glutamine gamma-glutamyltransferase 5 TGM5 0.011
3989 Glutaminyl-tRNA synthetase QARS 0.011
3988 Protein-glutamine gamma-glutamyltransferase K TGM1 0.011
163 D(1B) dopamine receptor DRD5 0.0109
1596 Protein-glutamine gamma-glutamyltransferase 2 TGM2 0.0107
6 Coagulation factor XIII A chain F13A1 0.0103
432 D(4) dopamine receptor DRD4 0.0102
638 D(3) dopamine receptor DRD3 0.0099
5178 Protein nrdI nrdI 0.0097
5181 Hypothetical protein yhdA azr 0.0097
5179 Probable aromatic acid decarboxylase pad1 0.0096
5202 Nitroreductase family protein BC_1844 0.0096
5201 FMN-binding protein DvMF_2023 0.0096
3293 Flavodoxin Not Available 0.0096
4614 Flavodoxin DVU_2680 0.0096
5172 Flavodoxin isiB 0.0096
5173 Flavodoxin isiB 0.0096
5182 Flavodoxin fldA 0.0096
5198 Flavodoxin-1 fldA 0.0096
5170 Epidermin decarboxylase epiD 0.0096
2586 Isopentenyl-diphosphate Delta-isomerase idi 0.0096
5187 Isopentenyl-diphosphate delta-isomerase fni 0.0096
5199 Isopentenyl-diphosphate delta-isomerase fni 0.0096
5175 Hypothetical protein SMU.260 SMU_260 0.0096
5197 Trp repressor binding protein WrbA, putative DR_A0214 0.0096
5200 NADH dehydrogenase nox 0.0096
5191 Morphinone reductase morB 0.0096
5131 PhzG phzG 0.0096
5193 Phenazine biosynthesis protein phzG phzG 0.0096
4405 Nitric oxide reductase fprA 0.0096
5190 Rubredoxin-oxygen oxidoreductase roo 0.0096
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0095
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0095
2339 Protein-glutamine gamma-glutamyltransferase E TGM3 0.0095
263 Neutral amino acid transporter B(0) SLC1A5 0.0093
3799 Hypoxanthine phosphoribosyltransferase hpt 0.0092
3719 Inosine-5'-monophosphate dehydrogenase guaB 0.0092
413 Amidophosphoribosyltransferase PPAT 0.0092
2515 Amidophosphoribosyltransferase purF 0.0092
3714 Amidophosphoribosyltransferase purF 0.0092
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0091
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0091
1881 Hexokinase-1 HK1 0.0088
4503 NADPH-flavin oxidoreductase frp 0.0088
5189 Trimethylamine dehydrogenase tmd 0.0088
4836 Ferredoxin-dependent glutamate synthase 2 gltS 0.0088
2207 Rhodopsin RHO 0.0088
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0086
851 5'-AMP-activated protein kinase subunit beta-2 PRKAB2 0.0086
388 AMP deaminase 1 AMPD1 0.0086
789 Alpha-1D adrenergic receptor ADRA1D 0.0086
2684 Histidine triad nucleotide-binding protein 1 HINT1 0.0084
3680 Dihydroorotate dehydrogenase A pyrDA 0.0084
4407 FMN-dependent NADH-azoreductase azoR 0.0084
5169 FMN-dependent NADH-azoreductase azoR 0.0084
5206 Phosphopantothenoylcysteine decarboxylase PPCDC 0.0083
3507 Chorismate synthase aroC 0.0083
5171 Chorismate synthase aroC 0.0083
378 Alpha-2C adrenergic receptor ADRA2C 0.0083
629 Alpha-2B adrenergic receptor ADRA2B 0.0082
1039 Histone deacetylase 9 HDAC9 0.008
6268 Hydroxyacid oxidase 1 HAO1 0.008
193 Beta-1 adrenergic receptor ADRB1 0.0079
6608 Serine/threonine-protein kinase Sgk1 SGK1 0.0077
766 Beta-2 adrenergic receptor ADRB2 0.0077
2775 Dihydroorotate dehydrogenase pyrD 0.0077
632 Alpha-1B adrenergic receptor ADRA1B 0.0077
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0076
4198 Fructose-1,6-bisphosphatase 1 FBP1 0.0076
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0075
408 Riboflavin kinase RFK 0.0074
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0074
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0074
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0074
297 Adenylate cyclase type 1 ADCY1 0.0074
318 Alpha-2A adrenergic receptor ADRA2A 0.0073
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0073
5180 L(+)-mandelate dehydrogenase mdlB 0.0073
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0073
1291 cAMP response element-binding protein CREB1 0.0073
2538 6-phospho-beta-glucosidase bglT bglT 0.0072
2393 Maltose-6'-phosphate glucosidase glvA 0.0072
128 Adenine phosphoribosyltransferase APRT 0.0071
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0071
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0071
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.007
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.007
6021 Adenosine kinase ADK 0.0068
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0067
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0067
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0067
4284 Pentaerythritol tetranitrate reductase onr 0.0065
76 Nitric-oxide synthase, brain NOS1 0.0065
4269 Hypoxanthine-guanine phosphoribosyltransferase, putative HGPRTase 0.0064
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0064
2439 Alpha,alpha-trehalose-phosphate synthase [UDP-forming] otsA 0.0062
3950 Cell division protein kinase 9 CDK9 0.0062
3968 Cell division protein kinase 8 CDK8 0.0062
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0061
4119 Cytochrome P450 2D6 CYP2D6 0.0061
654 Flavin reductase BLVRB 0.006
2632 Adenylosuccinate synthetase purA 0.0058
3323 Adenylosuccinate synthetase purA 0.0058
3975 Adenylosuccinate synthetase ADSS 0.0058
4598 Adenylosuccinate synthetase Adss 0.0058
6817 Adenylosuccinate synthetase purA 0.0058
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0058
2597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] glmS 0.0057
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0056
2206 Glucose-6-phosphate isomerase GPI 0.0054
3482 Cell division protein kinase 7 CDK7 0.0054
3959 Cell division protein kinase 4 CDK4 0.0054
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0053
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0052
6106 Cytochrome P450 2C18 CYP2C18 0.0051
20 Prostaglandin G/H synthase 1 PTGS1 0.0051
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.005
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.005
3955 Cell division protein kinase 6 CDK6 0.0049
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0049
4120 NADPH--cytochrome P450 reductase POR 0.0046
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0045
1742 D-HSCDK2 CDK2deltaT 0.0043
1771 Cell division control protein 2 homolog CDK1 0.0043
3321 Cell division control protein 2 homolog CRK2 0.0043
1058 Cell division protein kinase 5 CDK5 0.0042
4943 Cytochrome c6 petJ 0.0041
4934 Cytochrome c-551 nirM 0.0041
5218 Cytochrome c-551 nirM 0.0041
4936 Cytochrome c2 iso-2 Not Available 0.0041
4981 Iron-starvation protein PigA pigA 0.0041
4994 Hemoglobin-like protein HbO glbO 0.0041
4915 Cytochrome c-550 psbV 0.0041
4959 Cytochrome c-550 psbV 0.0041
5216 Cytochrome c-550 psbV 0.0041
4925 Cytochrome c-type protein SHP shp 0.0041
4998 Hemoglobin-like protein yjbI yjbI 0.0041
4905 Cytochrome c2 Not Available 0.0041
4939 Cytochrome c2 cycA 0.0041
4964 Cytochrome c2 cycA 0.0041
4979 Cytochrome c2 cycA 0.0041
6673 Cytochrome c2 cycA 0.0041
4909 CooA protein cooA 0.0041
4947 Bacterial hemoglobin vhb 0.0041
4975 Cytochrome c-556 RPA3973 0.0041
4984 Neuroglobin NGB 0.0041
3116 Bacterioferritin bfr 0.0041
4906 Bacterioferritin bfr 0.0041
4965 Bacterioferritin bfr 0.0041
4954 Soluble cytochrome b558 Not Available 0.0041
4961 Hemophore HasA hasA 0.0041
4910 Cytoglobin CYGB 0.0041
4976 Apocytochrome f petA 0.0041
6407 Apocytochrome f petA 0.0041
4916 Cyanoglobin glbN 0.0041
5000 HemO hemO 0.0041
4935 Cytochrome c-554 cycA1 0.0041
644 Heme oxygenase 2 HMOX2 0.0041
4982 Heme oxygenase 2 pbsA2 0.0041
4942 Diheme cytochrome c napB napB 0.0041
4931 Cytochrome P450 167A1 CYP167A1 0.0041
4922 Cytochrome c, putative SO_4144 0.0041
4971 Nonaheme cytochrome c hmcA 0.0041
4989 Cytochrome c551 peroxidase ccp 0.0041
5222 Cytochrome c551 peroxidase ccpA 0.0041
4904 Cytochrome c family protein GSU1996 0.0041
4907 Cytochrome c-L moxG 0.0041
6865 Cytochrome c-L moxG 0.0041
4999 Cytochrome P450 165B3 CYP165B3 0.0041
4972 P450cin cinA 0.0041
4764 Cytochrome P450 165C4 CYP165C4 0.0041
4960 Putative cytochrome P450-family protein SCO7417 0.0041
4926 Heme-based aerotactic transducer hemAT hemAT 0.0041
4952 Catalase/peroxidase katA 0.0041
3093 Catalase HPII katE 0.0041
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0041
4937 Cytochrome oxidase subunit II rcoxA 0.0041
4993 Hydroxylamine oxidoreductase hao1 0.0041
4903 Methyl-accepting chemotaxis protein Tar4 0.0041
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0041
822 Aldose reductase AKR1B1 0.0041
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0039
6030 Cytochrome P450 2B6 CYP2B6 0.0038
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0038
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0037
6143 Solute carrier family 22 member 7 SLC22A7 0.0034
3689 Endoglucanase A celA 0.0034
5563 Galectin-2 LGALS2 0.0034
5411 Slt-IIvB stxB2e 0.0034
5046 Ecotin eco 0.0034
5554 D-galactose-binding periplasmic protein mglB 0.0034
3741 D-galactose-binding periplasmic protein precursor mglB 0.0034
3009 Beta-glucanase Not Available 0.0034
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0034
5562 Hexokinase Not Available 0.0034
5568 Endoglucanase C307 celC307 0.0034
3744 Endoglucanase SS precursor celS 0.0034
3793 Aspartate ammonia-lyase aspA 0.0034
1875 Pulmonary surfactant-associated protein D SFTPD 0.0034
4668 Laminarinase TM_0024 0.0034
5569 Endo-1,4-beta glucanase EngF engF 0.0034
5553 Endoglucanase E1 Acel_0614 0.0034
5559 Neopullulanase nplT 0.0034
4670 Cellulase B celB 0.0034
5570 Endoglucanase E-4 celD 0.0034
4671 Endoglucanase C cenC 0.0034
4667 BH0236 protein BH0236 0.0034
844 Epidermal growth factor receptor EGFR 0.0033
4757 Cytochrome P450 2C9 CYP2C9 0.0032
4037 Hypothetical protein GPX1 0.0032
4297 Hypothetical protein SP_1951 0.0032
4521 Hypothetical protein BC_2969 0.0032
4540 Hypothetical protein TM_1070 0.0032
4555 Hypothetical protein MT1739 0.0032
4569 Hypothetical protein mshD 0.0032
4578 Hypothetical protein PA3270 0.0032
4747 Hypothetical protein PA3967 0.0032
5177 Hypothetical protein TM_0096 0.0032
5194 Hypothetical protein PA1204 0.0032
5240 Hypothetical protein Rv2991 0.0032
5370 Hypothetical protein TM_1158 0.0032
5710 Hypothetical protein Tb927.5.1360 0.0032
4289 Cytochrome P450 TT_P0059 0.0031
6262 Cytochrome P450 staP 0.0031
4992 Cytochrome c peroxidase Not Available 0.0031
6142 Solute carrier family 22 member 8 SLC22A8 0.0031
4920 Peroxidase/catalase katG 0.0031
3570 Cytochrome P450 152A1 cypC 0.003
4990 PpcA ppcA 0.003
4923 Cytochrome c3 DvMF_2499 0.003
4945 Cytochrome c3 Not Available 0.003
4949 Cytochrome c3 DVU_3171 0.003
4968 Cytochrome c3 cytc3 0.003
4997 Cytochrome c3 SO_2727 0.003
5219 Cytochrome c3 cyd 0.003
4948 Cytochrome c-553 Not Available 0.003
4902 Nine-heme cytochrome c Ddes_2038 0.003
5718 Cytochrome P450 2A6 CYP2A6 0.003
3189 High-molecular-weight cytochrome c hmcA 0.003
1184 Interferon beta IFNB1 0.003
4509 Acetoin(diacetyl) reductase budC 0.003
4813 Heme oxygenase hmuO 0.003
5769 Heme oxygenase Not Available 0.003
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.003
2230 Catalase CAT 0.003
3249 Catalase katA 0.003
3625 Catalase katA 0.003
4539 Catalase katA 0.003
4941 Catalase katB 0.003
4988 Sulfite oxidase, mitochondrial SUOX 0.003
2119 Cytochrome b5 CYB5A 0.003
2915 Sensor protein fixL fixL 0.003
4944 Sensor protein fixL fixL 0.003
3375 Acidic cytochrome c3 Not Available 0.003
4385 Cytochrome c' Not Available 0.003
4967 Cytochrome c' cycA 0.003
5038 Cytochrome c' Not Available 0.003
5223 Cytochrome c' cycP 0.003
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.003
5498 Maltoporin lamB 0.0029
5561 Maltoporin lamB 0.0029
1503 Galectin-7 LGALS7 0.0029
5247 Endo-1,4-beta-xylanase Not Available 0.0029
5248 Endo-1,4-beta-xylanase xlnA 0.0029
5250 Endo-1,4-beta-xylanase xyl 0.0029
4669 Endo-1,4-beta-xylanase A xynA 0.0029
4715 Endo-1,4-beta-xylanase A xlnA 0.0029
5560 Endo-1,4-beta-xylanase A xynA 0.0029
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0029
5416 Coat protein VP1 Not Available 0.0029
4622 Amylase Not Available 0.0029
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0029
2705 Dimethyl sulfoxide reductase dmsA 0.0029
1729 Solute carrier family 22 member 6 SLC22A6 0.0028
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0027
2531 Alpha-amylase amyE 0.0027
2948 Alpha-amylase amy 0.0027
3169 Alpha-amylase Not Available 0.0027
4819 Hydrolase Not Available 0.0027
5249 Hydrolase Not Available 0.0027
5436 Hydrolase Not Available 0.0027
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0027
2541 Neopullulanase 1 tvaI 0.0027
3547 Enterotoxin type B entB 0.0027
2324 Botulinum neurotoxin type B botB 0.0027
3747 Cellulase B precursor celB 0.0027
2606 Neopullulanase 2 tvaII 0.0027
4811 Amylosucrase ams 0.0027
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0027
2617 Nitric oxide synthase oxygenase nos 0.0027
2701 Nitric oxide synthase oxygenase nos 0.0027
518 Peroxidase/catalase T katG 0.0026
3670 Soluble cytochrome b562 precursor cybC 0.0026
3291 Cytochrome c-552 cycA 0.0026
4927 Cytochrome c-552 nrfA 0.0026
4938 Cytochrome c-552 cycA 0.0026
4953 Cytochrome c-552 nrfA 0.0026
5217 Cytochrome c-552 cycM 0.0026
3102 Flavohemoprotein hmp 0.0026
4969 Flavohemoprotein hmp 0.0026
4386 Hemoglobin-like protein HbN glbN 0.0026
4666 Fucose-binding lectin PA-IIL lecB 0.0026
3411 Cytochrome P450 121 cyp121 0.0026
2372 Bifunctional tail protein 9 0.0026
4830 Aldose 1-epimerase galM 0.0026
3365 Beta-amylase spoII 0.0026
3225 Shiga toxin B-chain stxB 0.0026
1675 Glucokinase GCK 0.0024
4662 Glucokinase glk 0.0024
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0024
2508 Cyclomaltodextrin glucanotransferase cgt 0.0024
2523 Cyclomaltodextrin glucanotransferase cgt 0.0024
3207 Cyclomaltodextrin glucanotransferase amyA 0.0024
3030 Salivary alpha-amylase AMY1A 0.0024
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0024
605 Fumarate reductase flavoprotein subunit frdA 0.0024
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0024
3673 Fumarate reductase flavoprotein subunit fccA 0.0024
4912 Fumarate reductase flavoprotein subunit ifcA 0.0024
6549 Fumarate reductase flavoprotein subunit frdA 0.0024
4692 A/G-specific adenine glycosylase mutY 0.0024
3221 Cytochrome c4 cc4 0.0024
4200 Cytochrome P450 1A2 CYP1A2 0.0024
3127 Nitrite reductase nirS 0.0024
3284 Nitrite reductase nirS 0.0024
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0024
2972 6-deoxyerythronolide B hydroxylase eryF 0.0024
2802 Endoglucanase G celCCG 0.0024
2570 Tetanus toxin tetX 0.0024
3668 Maltose-binding periplasmic protein precursor malE 0.0024
2240 Cell division protein kinase 2 CDK2 0.0023
4272 POSSIBLE CELLULASE CELA1 celA1 0.0023
4608 Putative cytochrome P450 SCO1207 0.0022
4963 Putative cytochrome P450 SCO2884 0.0022
6254 Putative cytochrome P450 SCO6998 0.0022
2440 Endoglucanase F celCCF 0.0022
2430 Chondroitinase B cslB 0.0022
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0021
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0021
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0021
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0021
1507 Cytochrome c CYCS 0.0021
260 Cytochrome P450 51 ERG11 0.002
761 Cytochrome P450 51 ERG11 0.002
3163 Cytochrome P450 51 cyp51 0.002
2245 Xylose isomerase xylA 0.002
2253 Xylose isomerase xylA 0.002
2260 Xylose isomerase xylA 0.002
2431 Xylose isomerase xylA 0.002
2252 Endoglucanase 5A cel5A 0.002
2723 Cholera enterotoxin subunit B ctxB 0.002
693 Hemoglobin subunit beta HBB 0.002
2427 Ferrichrome-iron receptor fhuA 0.0019
810 Heme oxygenase 1 HMOX1 0.0019
3391 Heme oxygenase 1 pbsA1 0.0019
4513 Pancreatic alpha-amylase AMY2A 0.0019
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0018
275 Arachidonate 5-lipoxygenase ALOX5 0.0017
2298 Cytochrome P450-cam camC 0.0016
290 Prostaglandin G/H synthase 2 PTGS2 0.0012
587 Serum albumin ALB 0.0011
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