DT-Web

DB00127 - Spermine


Identification
Name Spermine
Accession Number DB00127 (DB02564, EXPT02947, NUTR00055)
Type small molecule
Description A biogenic polyamine formed from spermidine. It is found in a wide variety of organisms and tissues and is an essential growth factor in some bacteria. It is found as a polycation at all pH values. Spermine is associated with nucleic acids, particularly in viruses, and is thought to stabilize the helical structure. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 202.3402
Groups approved
Monoisotopic Weight 202.215746852
Pharmacology
Indication For nutritional supplementation, also for treating dietary shortage or imbalance
Mechanism of action Spermine is derived from spermidine by spermine synthase. Spermine is a polyamine, a small organic cations that is absolutely required for eukaryotic cell growth. Spermine, is normally found in millimolar concentrations in the nucleus. Spermine functions directly as a free radical scavenger, and forms a variety of adducts that prevent oxidative damage to DNA. Oxidative damage to DNA by reactive oxygen species is a continual problem that cells must guard against to survive. Hence, spermine is a major natural intracellular compound capable of protecting DNA from free radical attack. Spermine is also implicated in the regulation of gene expression, the stabilization of chromatin, and the prevention of endonuclease-mediated DNA fragmentation.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Spermine synthase
Name Spermine synthase
Gene Name SMS
Pharmacological action yes
Actions ligand
References
  • Lopatin AN, Shantz LM, Mackintosh CA, Nichols CG, Pegg AE: Modulation of potassium channels in the hearts of transgenic and mutant mice with altered polyamine biosynthesis. J Mol Cell Cardiol. 2000 Nov;32(11):2007-24. - Pubmed
  • Korhonen VP, Niiranen K, Halmekyto M, Pietila M, Diegelman P, Parkkinen JJ, Eloranta T, Porter CW, Alhonen L, Janne J: Spermine deficiency resulting from targeted disruption of the spermine synthase gene in embryonic stem cells leads to enhanced sensitivity to antiproliferative drugs. Mol Pharmacol. 2001 Feb;59(2):231-8. - Pubmed
  • Cason AL, Ikeguchi Y, Skinner C, Wood TC, Holden KR, Lubs HA, Martinez F, Simensen RJ, Stevenson RE, Pegg AE, Schwartz CE: X-linked spermine synthase gene (SMS) defect: the first polyamine deficiency syndrome. Eur J Hum Genet. 2003 Dec;11(12):937-44. - Pubmed
  • Wang X, Ikeguchi Y, McCloskey DE, Nelson P, Pegg AE: Spermine synthesis is required for normal viability, growth, and fertility in the mouse. J Biol Chem. 2004 Dec 3;279(49):51370-5. Epub 2004 Sep 30. - Pubmed
  • Schwartz CE, Wang X, Stevenson RE, Pegg AE: Spermine synthase deficiency resulting in x-linked intellectual disability (snyder-robinson syndrome). Methods Mol Biol. 2011;720:437-45. - Pubmed
  • Wang X, Pegg AE: Use of (gyro) gy and spermine synthase transgenic mice to study functions of spermine. Methods Mol Biol. 2011;720:159-70. - Pubmed
  • Theiss C, Bohley P, Voigt J: Regulation by polyamines of ornithine decarboxylase activity and cell division in the unicellular green alga Chlamydomonas reinhardtii. Plant Physiol. 2002 Apr;128(4):1470-9. - Pubmed
  • Krauss M, Langnaese K, Richter K, Brunk I, Wieske M, Ahnert-Hilger G, Veh RW, Laube G: Spermidine synthase is prominently expressed in the striatal patch compartment and in putative interneurones of the matrix compartment. J Neurochem. 2006 Apr;97(1):174-89. Epub 2006 Mar 3. - Pubmed
  • Kobayashi M, Takao K, Shiota Y, Sugita Y, Takahashi M, Nakae D, Samejima K: Inhibition of putrescine aminopropyltransferase influences rat liver regeneration. Biol Pharm Bull. 2006 May;29(5):863-7. - Pubmed
DTHybrid score 0.8341
Spermine oxidase
Name Spermine oxidase
Gene Name SMOX
Pharmacological action yes
Actions ligand
References
  • Binda C, Angelini R, Federico R, Ascenzi P, Mattevi A: Structural bases for inhibitor binding and catalysis in polyamine oxidase. Biochemistry. 2001 Mar 6;40(9):2766-76. - Pubmed
  • Vujcic S, Diegelman P, Bacchi CJ, Kramer DL, Porter CW: Identification and characterization of a novel flavin-containing spermine oxidase of mammalian cell origin. Biochem J. 2002 Nov 1;367(Pt 3):665-75. - Pubmed
  • Vujcic S, Liang P, Diegelman P, Kramer DL, Porter CW: Genomic identification and biochemical characterization of the mammalian polyamine oxidase involved in polyamine back-conversion. Biochem J. 2003 Feb 15;370(Pt 1):19-28. - Pubmed
  • Wang Y, Murray-Stewart T, Devereux W, Hacker A, Frydman B, Woster PM, Casero RA Jr: Properties of purified recombinant human polyamine oxidase, PAOh1/SMO. Biochem Biophys Res Commun. 2003 May 16;304(4):605-11. - Pubmed
  • Bacchi CJ, Rattendi D, Faciane E, Yarlett N, Weiss LM, Frydman B, Woster P, Wei B, Marton LJ, Wittner M: Polyamine metabolism in a member of the phylum Microspora (Encephalitozoon cuniculi): effects of polyamine analogues. Microbiology. 2004 May;150(Pt 5):1215-24. - Pubmed
DTHybrid score 0.8339
DNA
Name DNA
Gene Name Not Available
Pharmacological action yes
Actions binder
References
  • Trubetskoy VS, Wolff JA, Budker VG: The role of a microscopic colloidally stabilized phase in solubilizing oligoamine-condensed DNA complexes. Biophys J. 2003 Feb;84(2 Pt 1):1124-30. - Pubmed
  • Cho SK, Kwon YJ: Polyamine/DNA polyplexes with acid-degradable polymeric shell as structurally and functionally virus-mimicking nonviral vectors. J Control Release. 2010 Dec 16. - Pubmed
  • Saminathan M, Thomas T, Shirahata A, Pillai CK, Thomas TJ: Polyamine structural effects on the induction and stabilization of liquid crystalline DNA: potential applications to DNA packaging, gene therapy and polyamine therapeutics. Nucleic Acids Res. 2002 Sep 1;30(17):3722-31. - Pubmed
DTHybrid score Not Available
Ornithine decarboxylase
Name Ornithine decarboxylase
Gene Name ODC1
Pharmacological action unknown
Actions product of
References
  • Nilsson J, Grahn B, Heby O: Antizyme inhibitor is rapidly induced in growth-stimulated mouse fibroblasts and releases ornithine decarboxylase from antizyme suppression. Biochem J. 2000 Mar 15;346 Pt 3:699-704. - Pubmed
  • Ray RM, Viar MJ, Yuan Q, Johnson LR: Polyamine depletion delays apoptosis of rat intestinal epithelial cells. Am J Physiol Cell Physiol. 2000 Mar;278(3):C480-9. - Pubmed
  • Korhonen VP, Niiranen K, Halmekyto M, Pietila M, Diegelman P, Parkkinen JJ, Eloranta T, Porter CW, Alhonen L, Janne J: Spermine deficiency resulting from targeted disruption of the spermine synthase gene in embryonic stem cells leads to enhanced sensitivity to antiproliferative drugs. Mol Pharmacol. 2001 Feb;59(2):231-8. - Pubmed
  • Rohn G, Els T, Hell K, Ernestus RI: Regional distribution of ornithine decarboxylase activity and polyamine levels in experimental cat brain tumors. Neurochem Int. 2001 Aug;39(2):135-40. - Pubmed
  • Ernestus RI, Rohn G, Schroder R, Els T, Klekner A, Paschen W, Klug N: Polyamine metabolism in brain tumours: diagnostic relevance of quantitative biochemistry. J Neurol Neurosurg Psychiatry. 2001 Jul;71(1):88-92. - Pubmed
  • Lee NK, Maclean HE: Polyamines, androgens and skeletal muscle hypertrophy. J Cell Physiol. 2010 Dec 7. - Pubmed
DTHybrid score 1.0548

Enzymes


Xanthine dehydrogenase/oxidase
Name Xanthine dehydrogenase/oxidase
Gene Name XDH
Actions inhibitor
References
  • Lovaas E, Carlin G: Spermine: an anti-oxidant and anti-inflammatory agent. Free Radic Biol Med. 1991;11(5):455-61. - Pubmed
DTHybrid score 0.6805
Diamine acetyltransferase 1
Name Diamine acetyltransferase 1
Gene Name SAT1
Actions substrate
References
  • Vujcic S, Halmekyto M, Diegelman P, Gan G, Kramer DL, Janne J, Porter CW: Effects of conditional overexpression of spermidine/spermine N1-acetyltransferase on polyamine pool dynamics, cell growth, and sensitivity to polyamine analogs. J Biol Chem. 2000 Dec 8;275(49):38319-28. - Pubmed
  • Hegardt C, Andersson G, Oredsson SM: Changes in polyamine metabolism during glucocorticoid-induced programmed cell death in mouse thymus. Cell Biol Int. 2000;24(12):871-80. - Pubmed
  • Marverti G, Bettuzzi S, Astancolle S, Pinna C, Monti MG, Moruzzi MS: Differential induction of spermidine/spermine N1-acetyltransferase activity in cisplatin-sensitive and -resistant ovarian cancer cells in response to N1,N12-bis(ethyl)spermine involves transcriptional and post-transcriptional regulation. Eur J Cancer. 2001 Jan;37(2):281-9. - Pubmed
  • Scorcioni F, Corti A, Davalli P, Astancolle S, Bettuzzi S: Manipulation of the expression of regulatory genes of polyamine metabolism results in specific alterations of the cell-cycle progression. Biochem J. 2001 Feb 15;354(Pt 1):217-23. - Pubmed
  • Min SH, Simmen RC, Alhonen L, Halmekyto M, Porter CW, Janne J, Simmen FA: Altered levels of growth-related and novel gene transcripts in reproductive and other tissues of female mice overexpressing spermidine/spermine N1-acetyltransferase (SSAT). J Biol Chem. 2002 Feb 1;277(5):3647-57. Epub 2001 Nov 14. - Pubmed
  • Limsuwun K, Jones PG: Spermidine acetyltransferase is required to prevent spermidine toxicity at low temperatures in Escherichia coli. J Bacteriol. 2000 Oct;182(19):5373-80. - Pubmed
DTHybrid score 1.5323
Diamine acetyltransferase 2
Name Diamine acetyltransferase 2
Gene Name SAT2
Actions substrate
References
  • Chen Y, Vujcic S, Liang P, Diegelman P, Kramer DL, Porter CW: Genomic identification and biochemical characterization of a second spermidine/spermine N1-acetyltransferase. Biochem J. 2003 Aug 1;373(Pt 3):661-7. - Pubmed
  • Coleman CS, Stanley BA, Jones AD, Pegg AE: Spermidine/spermine-N1-acetyltransferase-2 (SSAT2) acetylates thialysine and is not involved in polyamine metabolism. Biochem J. 2004 Nov 15;384(Pt 1):139-48. - Pubmed
  • Vogel NL, Boeke M, Ashburner BP: Spermidine/Spermine N1-Acetyltransferase 2 (SSAT2) functions as a coactivator for NF-kappaB and cooperates with CBP and P/CAF to enhance NF-kappaB-dependent transcription. Biochim Biophys Acta. 2006 Oct;1759(10):470-7. Epub 2006 Aug 30. - Pubmed
  • Limsuwun K, Jones PG: Spermidine acetyltransferase is required to prevent spermidine toxicity at low temperatures in Escherichia coli. J Bacteriol. 2000 Oct;182(19):5373-80. - Pubmed
DTHybrid score 0.8352

Transporters


Organic cation/carnitine transporter 1
Name Organic cation/carnitine transporter 1
Gene Name SLC22A4
Actions inhibitor
References
  • Yabuuchi H, Tamai I, Nezu J, Sakamoto K, Oku A, Shimane M, Sai Y, Tsuji A: Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. J Pharmacol Exp Ther. 1999 May;289(2):768-73. - Pubmed
DTHybrid score 0.4594
Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions substrate
References
  • Busch AE, Quester S, Ulzheimer JC, Waldegger S, Gorboulev V, Arndt P, Lang F, Koepsell H: Electrogenic properties and substrate specificity of the polyspecific rat cation transporter rOCT1. J Biol Chem. 1996 Dec 20;271(51):32599-604. - Pubmed
DTHybrid score 0.4415

Predictions


Id Partner name Gene Name Score
6144 Solute carrier family 22 member 2 SLC22A2 0.0949
118 Organic cation/carnitine transporter 2 SLC22A5 0.0939
2429 Putrescine-binding periplasmic protein potF 0.0938
4823 L-allo-threonine aldolase TM_1744 0.0823
2803 Pyridoxine 5'-phosphate synthase pdxJ 0.0793
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0739
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0663
3193 Serine hydroxymethyltransferase glyA 0.0645
3342 Serine hydroxymethyltransferase glyA 0.0645
4119 Cytochrome P450 2D6 CYP2D6 0.0585
4512 Cytochrome P450 3A4 CYP3A4 0.0552
6147 Solute carrier family 22 member 3 SLC22A3 0.0538
6142 Solute carrier family 22 member 8 SLC22A8 0.0494
1588 Multidrug resistance protein 1 ABCB1 0.0473
4200 Cytochrome P450 1A2 CYP1A2 0.0471
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0444
6020 Aldehyde oxidase AOX1 0.0337
1898 Cytochrome P450 1B1 CYP1B1 0.0314
5492 Cystathionine gamma-synthase metB 0.0273
5491 Methionine gamma-lyase mdeA 0.0273
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0254
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0242
1729 Solute carrier family 22 member 6 SLC22A6 0.0233
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0233
6143 Solute carrier family 22 member 7 SLC22A7 0.0231
4118 Cytochrome P450 3A5 CYP3A5 0.0226
2758 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase bioA 0.0215
4757 Cytochrome P450 2C9 CYP2C9 0.0212
3560 Gentamicin 3'-acetyltransferase aacC1 0.021
617 Muscarinic acetylcholine receptor M2 CHRM2 0.021
6013 Cytochrome P450 2E1 CYP2E1 0.0207
6024 Cytochrome P450 1A1 CYP1A1 0.0207
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0205
3923 Cholinesterase BCHE 0.0201
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0201
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.02
6016 Cytochrome P450 2C19 CYP2C19 0.0196
556 Alpha-1A adrenergic receptor ADRA1A 0.0189
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0188
6107 Cytochrome P450 3A7 CYP3A7 0.0183
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0181
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.018
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0178
862 Multidrug resistance-associated protein 1 ABCC1 0.0177
349 Serine--pyruvate aminotransferase AGXT 0.0176
896 Glutathione S-transferase Mu 1 GSTM1 0.0175
1405 Thiopurine S-methyltransferase TPMT 0.0172
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0171
492 Histamine H1 receptor HRH1 0.0168
831 D(2) dopamine receptor DRD2 0.0167
63 Malate dehydrogenase mdh 0.0165
2329 Malate dehydrogenase mdh 0.0165
3445 Malate dehydrogenase mdh 0.0165
4420 Malate dehydrogenase mdh 0.0165
4438 Malate dehydrogenase mdh 0.0165
2249 Aspartate aminotransferase aspC 0.0158
2671 Aspartate aminotransferase aspC 0.0158
5490 Aspartate aminotransferase Not Available 0.0158
327 Glutathione reductase gor 0.0156
5110 Glutathione reductase GR2 0.0156
776 Bile salt export pump ABCB11 0.0154
3823 Cytokine receptor common gamma chain IL2RG 0.0151
893 [Citrate [pro-3S]-lyase] ligase citC 0.0149
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0149
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0149
6030 Cytochrome P450 2B6 CYP2B6 0.0149
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0144
150 Cationic amino acid transporter 3 SLC7A3 0.0144
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.0144
58 Cationic amino acid transporter 4 SLC7A4 0.0144
817 DNA topoisomerase 2-alpha TOP2A 0.0139
1757 Myeloperoxidase MPO 0.0139
1152 Glycogen phosphorylase, muscle form PYGM 0.0139
587 Serum albumin ALB 0.0136
502 5-hydroxytryptamine 2A receptor HTR2A 0.0135
290 Prostaglandin G/H synthase 2 PTGS2 0.0132
6168 Solute carrier family 22 member 16 SLC22A16 0.0132
724 Interleukin-2 receptor alpha chain IL2RA 0.0131
717 Interleukin-2 receptor subunit beta IL2RB 0.0131
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.013
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0123
2472 Voltage-gated potassium channel kcsA 0.012
6366 Voltage-gated potassium channel kcsA 0.012
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0119
4924 Cytochrome P450 2C8 CYP2C8 0.0118
766 Beta-2 adrenergic receptor ADRB2 0.0118
6171 Solute carrier family 28 member 3 SLC28A3 0.0118
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0118
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0118
23 D(1A) dopamine receptor DRD1 0.0116
1024 Solute carrier family 22 member 11 SLC22A11 0.0114
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0113
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0113
221 Lysyl-tRNA synthetase KARS 0.0112
378 Alpha-2C adrenergic receptor ADRA2C 0.0111
1181 Alpha-1-acid glycoprotein 1 ORM1 0.011
1656 CYP2B protein CYP2B 0.0108
477 DNA topoisomerase 4 subunit A parC 0.0106
886 DNA topoisomerase 4 subunit A parC 0.0106
6226 DNA topoisomerase 4 subunit A parC 0.0106
6148 Multidrug resistance-associated protein 7 ABCC10 0.0105
404 DNA gyrase subunit A gyrA 0.0104
6224 DNA gyrase subunit A gyrA 0.0104
474 Acetylcholinesterase ACHE 0.0103
193 Beta-1 adrenergic receptor ADRB1 0.0102
3811 Cytochrome P450 19A1 CYP19A1 0.0101
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0101
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0101
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.01
3932 Glutathione S-transferase A2 GSTA2 0.01
551 Carnitine O-acetyltransferase CRAT 0.01
4031 Glutathione S-transferase A1 GSTA1 0.01
629 Alpha-2B adrenergic receptor ADRA2B 0.0099
6163 Copper-transporting ATPase 2 ATP7B 0.0099
6165 Copper-transporting ATPase 1 ATP7A 0.0099
619 Low-affinity cationic amino acid transporter 2 SLC7A2 0.0098
509 Thymidine kinase TK 0.0097
570 Thymidine kinase TK 0.0097
2559 Thymidine kinase TK 0.0097
3430 Thymidine kinase tdk 0.0097
3518 Thymidine kinase TK 0.0097
5301 Thymidine kinase tdk 0.0097
5771 Thymidine kinase ORF36 0.0097
7009 Thymidine kinase ORF36 0.0097
6136 Multidrug resistance-associated protein 5 ABCC5 0.0096
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0095
6146 High affinity copper uptake protein 1 SLC31A1 0.0094
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0094
2164 Multidrug resistance-associated protein 4 ABCC4 0.0093
632 Alpha-1B adrenergic receptor ADRA1B 0.0092
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0092
6859 Protein S100-A4 S100A4 0.0091
5126 Arginase rocF 0.0091
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0091
672 Prostaglandin F2-alpha receptor PTGFR 0.009
908 Glutathione S-transferase theta-1 GSTT1 0.009
318 Alpha-2A adrenergic receptor ADRA2A 0.0088
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0087
6151 Monocarboxylate transporter 10 SLC16A10 0.0087
6137 Multidrug resistance-associated protein 6 ABCC6 0.0086
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0085
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0085
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0085
499 Arginine decarboxylase ADC 0.0084
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0084
341 5-hydroxytryptamine 3 receptor HTR3A 0.0083
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0083
320 5-hydroxytryptamine 1A receptor HTR1A 0.0082
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0082
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0082
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0082
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0082
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0078
6106 Cytochrome P450 2C18 CYP2C18 0.0075
723 Cytosolic phospholipase A2 PLA2G4A 0.0075
338 DNA polymerase UL30 0.0073
379 DNA polymerase UL54 0.0073
697 DNA polymerase ORF28 0.0073
2482 DNA polymerase 43 0.0073
4104 DNA polymerase BALF5 0.0073
624 Guanidinoacetate N-methyltransferase GAMT 0.0073
6010 Thiamine transporter 1 SLC19A2 0.0073
904 Glutathione S-transferase P GSTP1 0.0072
124 Histamine H2 receptor HRH2 0.0072
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0072
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.007
824 Sodium-dependent serotonin transporter SLC6A4 0.007
465 Calmodulin CALM1 0.007
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0067
175 Thiamin pyrophosphokinase 1 TPK1 0.0066
4604 Liver carboxylesterase 1 CES1 0.0066
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0066
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0065
976 Platelet glycoprotein IX GP9 0.0065
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0065
6014 Cytochrome P450 2A13 CYP2A13 0.0064
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0064
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0063
756 Sex hormone-binding globulin SHBG 0.0062
789 Alpha-1D adrenergic receptor ADRA1D 0.0062
4120 NADPH--cytochrome P450 reductase POR 0.0061
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0061
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0061
5718 Cytochrome P450 2A6 CYP2A6 0.006
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0059
6432 Transporter snf 0.0059
3939 Amine oxidase [flavin-containing] B MAOB 0.0058
3941 Amine oxidase [flavin-containing] A MAOA 0.0057
4773 Deoxycytidine kinase DCK 0.0057
738 Monocarboxylate transporter 1 SLC16A1 0.0056
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0054
577 Argininosuccinate lyase ASL 0.0054
834 Arginase-2, mitochondrial ARG2 0.0054
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0053
2300 Lysozyme E 0.0053
3633 Lysozyme R 0.0053
5597 Lysozyme 17 0.0053
5682 Ribonuclease pancreatic RNASE1 0.0052
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0052
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0052
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0052
769 High-affinity choline transporter 1 SLC5A7 0.0052
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0052
576 Choline O-acetyltransferase CHAT 0.0052
1686 Choline transporter-like protein 1 SLC44A1 0.0052
700 Choline dehydrogenase, mitochondrial CHDH 0.0052
3927 Choline transporter-like protein 3 SLC44A3 0.0052
3926 Choline transporter-like protein 2 SLC44A2 0.0052
861 Choline kinase alpha CHKA 0.0052
3922 Phospholipase D2 PLD2 0.0052
3925 Choline transporter-like protein 4 SLC44A4 0.0052
3924 Phospholipase D1 PLD1 0.0052
1074 Urokinase-type plasminogen activator PLAU 0.0052
6141 Sodium/bile acid cotransporter SLC10A1 0.0051
7 Nitric oxide synthase, inducible NOS2 0.0051
1374 Natriuretic peptides B NPPB 0.0051
1827 Gap junction alpha-1 protein GJA1 0.0051
1908 Vascular cell adhesion protein 1 VCAM1 0.0051
3876 Aromatic-L-amino-acid decarboxylase DDC 0.005
400 Coagulation factor IX F9 0.005
5461 Coagulation factor IX F9 0.005
291 Nitric-oxide synthase, endothelial NOS3 0.005
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0049
740 Argininosuccinate synthase ASS1 0.0048
865 Argininosuccinate synthase ASS1 0.0048
2680 Argininosuccinate synthase argG 0.0048
3194 Argininosuccinate synthase argG 0.0048
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0047
731 HIV-1 protease HIV-1 protease 0.0047
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0046
604 Vitamin K-dependent protein Z PROZ 0.0046
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0046
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0045
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.0043
751 Potassium channel subfamily K member 6 KCNK6 0.0042
422 Vitamin K-dependent protein C PROC 0.0042
1245 Vitamin K-dependent protein S PROS1 0.0042
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0041
6070 Nischarin NISCH 0.0041
1360 Sphingomyelin phosphodiesterase SMPD1 0.0041
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.004
20 Prostaglandin G/H synthase 1 PTGS1 0.004
450 Muscarinic acetylcholine receptor M4 CHRM4 0.004
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.004
4192 DNA topoisomerase 2-beta TOP2B 0.0039
694 Matrix protein 2 M 0.0039
183 Vascular endothelial growth factor A VEGFA 0.0039
172 Potassium channel subfamily K member 1 KCNK1 0.0039
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0037
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0037
1830 5'-nucleotidase NT5E 0.0035
798 Osteocalcin BGLAP 0.0035
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0035
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0035
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0035
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0035
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0034
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0034
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0034
136 Estrogen receptor ESR1 0.0034
125 DNA polymerase beta POLB 0.0034
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0034
131 Synaptic vesicular amine transporter SLC18A2 0.0034
3906 Serine dehydratase-like SDSL 0.0033
3908 P-selectin cytoplasmic tail-associated protein pcap 0.0033
3915 Cysteine sulfinic acid decarboxylase-related protein 1 CSAD 0.0033
3914 Alanine-glyoxylate aminotransferase homolog TLH6 0.0033
3883 Ornithine aminotransferase variant Not Available 0.0033
306 Pyridoxal phosphate phosphatase PDXP 0.0033
3911 Uncharacterized protein C20orf38 SPTLC3 0.0033
3910 O-phosphoseryl-tRNA(Sec) selenium transferase SEPSECS 0.0033
3891 Putative L-Dopa decarboxylase DDC 0.0033
3909 Hepatic peroxysomal alanine:glyoxylate aminotransferase Not Available 0.0033
3880 Serine hydroxymethyltransferase 1 Not Available 0.0033
3881 Selenocysteine lyase variant Not Available 0.0033
3878 GAD1 protein GAD1 0.0033
3887 Phosphorylase PYGB 0.0033
3893 DDC protein DDC 0.0033
855 Sphingosine-1-phosphate lyase 1 SGPL1 0.0033
3903 Aminolevulinate, delta-, synthase 2 ALAS2 0.0033
664 Glutamate decarboxylase 2 GAD2 0.0033
3890 Glutamate decarboxylase 2 GAD2 0.0033
3896 CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase GADL1 0.0033
3886 Migration-inducing protein 4 ALAS1 0.0033
3894 KIAA0251 protein PDXDC1 0.0033
3875 Glycogen phosphorylase, brain form PYGB 0.0033
3882 Brain glycogen phosphorylase variant Not Available 0.0033
3905 Molybdenum cofactor sulfurase MOCOS 0.0033
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0033
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0033
2251 Thymidylate kinase tmk 0.0033
2254 Thymidylate kinase DTYMK 0.0033
3522 Thymidylate kinase tmk 0.0033
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0032
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0032
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0032
369 Coagulation factor VII F7 0.0032
828 Phenylalanine-4-hydroxylase PAH 0.0032
3109 Phenylalanine-4-hydroxylase phhA 0.0032
2257 Uridine phosphorylase udp 0.0031
5132 Uridine phosphorylase udp 0.0031
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0031
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0031
869 Estrogen receptor beta ESR2 0.0031
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.003
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.003
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0029
3917 Methylenetetrahydrofolate reductase MTHFR 0.0029
713 Sodium-dependent dopamine transporter SLC6A3 0.0029
468 Cytochrome P450 4A11 CYP4A11 0.0028
1341 Histamine H3 receptor HRH3 0.0028
472 Ornithine aminotransferase, mitochondrial OAT 0.0027
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0027
435 Kynureninase KYNU 0.0027
4654 Kynureninase kynU 0.0027
3913 Glutamic acid decarboxylase GAD65 0.0027
6031 Cytochrome P450 3A43 CYP3A43 0.0027
3874 Proline synthetase co-transcribed bacterial homolog protein PROSC 0.0027
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0027
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0027
420 Glutamate decarboxylase 1 GAD1 0.0027
3900 Glutamate decarboxylase 1 GAD1 0.0027
665 Phosphoserine aminotransferase PSAT1 0.0027
4652 Phosphoserine aminotransferase serC 0.0027
3 Histidine decarboxylase HDC 0.0027
534 Threonine synthase-like 1 THNSL1 0.0027
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0027
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0027
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0027
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0027
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.0027
184 L-serine dehydratase SDS 0.0027
491 Serine palmitoyltransferase 1 SPTLC1 0.0027
727 Serine palmitoyltransferase 2 SPTLC2 0.0027
431 Serine racemase SRR 0.0027
89 Cysteine sulfinic acid decarboxylase CSAD 0.0027
6111 DNA polymerase epsilon subunit 4 POLE4 0.0027
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0027
868 Cystathionine gamma-lyase CTH 0.0027
6112 DNA polymerase epsilon subunit 3 POLE3 0.0027
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0026
6110 DNA polymerase epsilon subunit 2 POLE2 0.0026
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0026
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0026
164 Histamine H4 receptor HRH4 0.0026
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0026
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0026
76 Nitric-oxide synthase, brain NOS1 0.0026
426 Aspartate aminotransferase, mitochondrial GOT2 0.0025
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0025
3877 Growth-inhibiting protein 18 GIG18 0.0024
163 D(1B) dopamine receptor DRD5 0.0024
169 Cysteine desulfurase, mitochondrial NFS1 0.0024
3884 SHMT2 protein SHMT2 0.0024
3901 SHMT2 protein SHMT2 0.0024
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0024
3879 Serine hydroxymethyltransferase 2 Not Available 0.0024
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0024
239 Coagulation factor X F10 0.0024
358 Cystathionine beta-synthase CBS 0.0024
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0024
10 Glycogen phosphorylase, liver form PYGL 0.0023
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0023
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0023
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0023
432 D(4) dopamine receptor DRD4 0.0023
735 Alanine aminotransferase 1 GPT 0.0023
3904 Alanine aminotransferase 2 GPT2 0.0023
763 Tyrosine aminotransferase TAT 0.0023
5493 Tyrosine aminotransferase Not Available 0.0023
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0022
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0022
6167 Organic solute transporter subunit beta OSTB 0.0022
6166 Organic solute transporter subunit alpha OSTA 0.0022
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0022
638 D(3) dopamine receptor DRD3 0.0022
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0022
146 Androgen receptor AR 0.0022
4203 Histamine N-methyltransferase HNMT 0.0021
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0021
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0021
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0021
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0021
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.002
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.002
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.002
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.002
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.002
342 P protein [Includes: DNA-directed DNA polymerase P 0.002
612 P protein [Includes: DNA-directed DNA polymerase P 0.002
603 DNA polymerase alpha catalytic subunit POLA1 0.002
54 Prothrombin F2 0.002
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.002
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0019
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0019
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0019
467 Delta-type opioid receptor OPRD1 0.0019
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0019
696 Kappa-type opioid receptor OPRK1 0.0019
847 Mu-type opioid receptor OPRM1 0.0018
5626 Nucleoside diphosphate kinase B NME2 0.0017
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0017
702 UMP-CMP kinase CMPK1 0.0017
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0017
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0017
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0017
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0017
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0017
1864 RET proto-oncogene RET 0.0015
277 Purine nucleoside phosphorylase PNP 0.0015
2870 Purine nucleoside phosphorylase punA 0.0015
2945 Purine nucleoside phosphorylase punA 0.0015
4659 Purine nucleoside phosphorylase TM_1596 0.0015
4825 Purine nucleoside phosphorylase TTHA1435 0.0015
380 Cytochrome P450 17A1 CYP17A1 0.0015
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0015
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0015
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0015
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0015
1517 Beta-3 adrenergic receptor ADRB3 0.0015
153 Dopamine beta-hydroxylase DBH 0.0014
5294 Nucleoside diphosphate kinase A NME1 0.0014
6218 Pannexin-1 PANX1 0.0014
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0013
436 5-hydroxytryptamine 2B receptor HTR2B 0.0013
4486 Phenol 2-hydroxylase component B pheA2 0.0013
4439 Ferredoxin reductase bphA4 0.0013
4477 Dihydrolipoyl dehydrogenase lpdV 0.0013
5077 Dihydrolipoyl dehydrogenase Not Available 0.0013
5117 Dihydrolipoyl dehydrogenase lpd 0.0013
1618 High affinity nerve growth factor receptor NTRK1 0.0013
5078 Amine oxidase, flavin-containing PSPTO1126 0.0012
5122 Mersacidin decarboxylase mrsD 0.0012
526 Thioredoxin reductase trxB 0.0012
3767 Thioredoxin reductase trxB 0.0012
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0012
3763 5,10-methylenetetrahydrofolate reductase metF 0.0012
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0012
5094 5,10-methylenetetrahydrofolate reductase metF 0.0012
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0012
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0012
5115 FkbI fkbI 0.0012
3133 UDP-galactopyranose mutase glf 0.0012
5099 UDP-galactopyranose mutase glf 0.0012
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0012
5095 Putidaredoxin reductase camA 0.0012
5083 Cryptochrome DASH cry 0.0012
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0012
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0012
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0012
5081 L-aspartate oxidase nadB 0.0012
5111 Phenylacetone monooxygenase pamO 0.0012
1410 Oxidoreductase HSD17B6 0.0012
4725 Oxidoreductase Not Available 0.0012
5124 Oxidoreductase Not Available 0.0012
5109 Outer membrane protein p64k or PM-6 m-6 0.0012
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0012
725 5-hydroxytryptamine 1D receptor HTR1D 0.0012
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0012
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0012
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0012
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0012
885 5-hydroxytryptamine 1B receptor HTR1B 0.0012
3587 Gastrotropin FABP6 0.0012
3810 Catechol O-methyltransferase COMT 0.0011
590 5-hydroxytryptamine 2C receptor HTR2C 0.0011
228 Beta platelet-derived growth factor receptor PDGFRB 0.0011
714 Glutathione reductase, mitochondrial GSR 0.0011
6149 Solute carrier family 22 member 10 SLC22A10 0.0011
3102 Flavohemoprotein hmp 0.0011
4969 Flavohemoprotein hmp 0.0011
4440 NADH peroxidase npr 0.0011
5072 N,N-dimethylglycine oxidase dmg 0.0011
5073 Ferredoxin--NADP reductase petH 0.0011
5076 Ferredoxin--NADP reductase fpr 0.0011
5119 Ferredoxin--NADP reductase petH 0.0011
5121 Ferredoxin--NADP reductase fpr 0.0011
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0011
3594 Deoxyribodipyrimidine photo-lyase phr 0.0011
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0011
5080 Deoxyribodipyrimidine photo-lyase phr 0.0011
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0011
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0011
2526 NADPH-ferredoxin reductase fprA fprA 0.0011
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0011
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0011
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0011
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0011
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0011
2470 Pyruvate oxidase pox5 0.0011
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0011
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.001
504 Mast/stem cell growth factor receptor KIT 0.001
2268 Cholesterol oxidase choB 0.001
2822 Cholesterol oxidase choA 0.001
737 Mineralocorticoid receptor NR3C2 0.001
126 D-lactate dehydrogenase dld 0.001
3545 D-lactate dehydrogenase Not Available 0.001
4510 D-lactate dehydrogenase ldhA 0.001
605 Fumarate reductase flavoprotein subunit frdA 0.001
2709 Fumarate reductase flavoprotein subunit SO_0970 0.001
3673 Fumarate reductase flavoprotein subunit fccA 0.001
4912 Fumarate reductase flavoprotein subunit ifcA 0.001
6549 Fumarate reductase flavoprotein subunit frdA 0.001
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.001
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.001
2893 Glycine oxidase thiO 0.001
33 Cystine/glutamate transporter SLC7A11 0.001
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0009
614 Progesterone receptor PGR 0.0009
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0009
2567 Thymidylate synthase thyX thyX 0.0009
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0009
2823 Trypanothione reductase TPR 0.0009
2769 P-hydroxybenzoate hydroxylase pobA 0.0009
2809 P-hydroxybenzoate hydroxylase pobA 0.0009
489 Monocarboxylate transporter 2 SLC16A7 0.0009
6085 Fatty acid-binding protein, intestinal FABP2 0.0009
2380 Monomeric sarcosine oxidase soxA 0.0008
6645 D-amino-acid oxidase DAO 0.0008
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0008
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0008
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0008
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0007
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0007
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0007
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0007
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0007
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0007
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0007
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0007
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0007
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0007
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0007
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0007
816 Biliverdin reductase A BLVRA 0.0007
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0007
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0007
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0007
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0007
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0007
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0006
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0006
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0006
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0006
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0006
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0006
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0006
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0006
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0006
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0006
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0006
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0006
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0006
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0006
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0006
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0006
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0006
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0006
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0006
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0006
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0006
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0006
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0006
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0006
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0006
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0006
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0006
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0006
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0006
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0006
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0006
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0006
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0006
644 Heme oxygenase 2 HMOX2 0.0006
4982 Heme oxygenase 2 pbsA2 0.0006
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0006
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0006
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0006
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0006
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0006
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0006
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0006
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0006
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0006
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0006
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0006
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0006
729 GDP-L-fucose synthetase TSTA3 0.0006
3463 GDP-L-fucose synthetase fcl 0.0006
167 L-lactate dehydrogenase C chain LDHC 0.0006
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0006
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0006
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0006
3726 D-3-phosphoglycerate dehydrogenase serA 0.0006
4291 D-3-phosphoglycerate dehydrogenase serA 0.0006
206 3-keto-steroid reductase HSD17B7 0.0006
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0006
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0006
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0006
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0006
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0006
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0006
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0006
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0006
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0006
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0006
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0006
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0006
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0006
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0006
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0006
34 7-dehydrocholesterol reductase DHCR7 0.0006
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0006
711 UDP-glucose 6-dehydrogenase UGDH 0.0006
3672 UDP-glucose 6-dehydrogenase hasB 0.0006
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0006
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0006
107 C-4 methylsterol oxidase SC4MOL 0.0006
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0006
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0006
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0006
643 Peroxisomal bifunctional enzyme EHHADH 0.0006
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0006
646 Malate dehydrogenase, cytoplasmic MDH1 0.0006
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0006
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0006
328 Sorbitol dehydrogenase SORD 0.0006
396 Alcohol dehydrogenase 4 ADH4 0.0006
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0006
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0006
597 Dihydropteridine reductase QDPR 0.0006
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0006
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0006
666 NADP-dependent malic enzyme ME1 0.0006
857 Malate dehydrogenase, mitochondrial MDH2 0.0005
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0005
77 L-lactate dehydrogenase B chain LDHB 0.0005
12 Alcohol dehydrogenase class 3 ADH5 0.0005
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0005
6026 Alcohol dehydrogenase 6 ADH6 0.0005
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0005
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0005
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0005
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0005
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0005
626 Cysteine dioxygenase type 1 CDO1 0.0005
627 11-cis retinol dehydrogenase RDH5 0.0005
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0005
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0005
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0005
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0005
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0005
473 L-lactate dehydrogenase A chain LDHA 0.0005
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0005
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0005
569 Retinal dehydrogenase 2 ALDH1A2 0.0005
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0005
13 Aminomethyltransferase, mitochondrial AMT 0.0005
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0005
611 Retinal dehydrogenase 1 ALDH1A1 0.0005
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0005
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0005
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0005
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0005
251 Alcohol dehydrogenase 1A ADH1A 0.0005
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0005
279 Tyrosinase TYR 0.0005
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0004
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0004
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0004
654 Flavin reductase BLVRB 0.0004
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0004
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0004
810 Heme oxygenase 1 HMOX1 0.0004
3391 Heme oxygenase 1 pbsA1 0.0004
444 Alcohol dehydrogenase 1B ADH1B 0.0004
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0004
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0004
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0004
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0004
517 Alcohol dehydrogenase 1C ADH1C 0.0004
822 Aldose reductase AKR1B1 0.0003
365 Dihydrofolate reductase DHFR 0.0003
2381 Dihydrofolate reductase DFR1 0.0003
2833 Dihydrofolate reductase Not Available 0.0003
2931 Dihydrofolate reductase folA 0.0003
3544 Dihydrofolate reductase folA 0.0003
3682 Dihydrofolate reductase folA 0.0003
6642 Dihydrofolate reductase folA 0.0003
6756 Dihydrofolate reductase dfrA 0.0003
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