DT-Web

DB04263 - G418


Identification
Name G418
Accession Number DB04263 (EXPT01586)
Type small molecule
Description G418 (also known as Geneticin) is an aminoglycoside antibiotic similar in structure to gentamicin B1. It is produced by Micromonospora rhodorangea. G418 blocks polypeptide synthesis by inhibiting the elongation step in both prokaryotic and eukaryotic cells. Resistance to G418 is conferred by the neo gene from Tn5 encoding an aminoglycoside 3'-phosphotransferase, APH 3' II. G418 is commonly used in laboratory research to select genetically engineered cells.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 496.5524
Groups experimental
Monoisotopic Weight 496.27444352
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Ornithine decarboxylase
Name Ornithine decarboxylase
Gene Name ODC1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.6778

Predictions


Id Partner name Gene Name Score
4823 L-allo-threonine aldolase TM_1744 0.0823
2803 Pyridoxine 5'-phosphate synthase pdxJ 0.0793
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0739
2429 Putrescine-binding periplasmic protein potF 0.0732
3193 Serine hydroxymethyltransferase glyA 0.0645
3342 Serine hydroxymethyltransferase glyA 0.0645
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0511
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0444
833 Organic cation/carnitine transporter 1 SLC22A4 0.0418
123 Diamine acetyltransferase 1 SAT1 0.0278
5492 Cystathionine gamma-synthase metB 0.0273
5491 Methionine gamma-lyase mdeA 0.0273
303 Diamine acetyltransferase 2 SAT2 0.027
1317 Spermine synthase SMS 0.027
623 Spermine oxidase SMOX 0.027
2758 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase bioA 0.0215
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.02
349 Serine--pyruvate aminotransferase AGXT 0.0176
2249 Aspartate aminotransferase aspC 0.0158
2671 Aspartate aminotransferase aspC 0.0158
5490 Aspartate aminotransferase Not Available 0.0158
3947 Xanthine dehydrogenase/oxidase XDH 0.0147
1152 Glycogen phosphorylase, muscle form PYGM 0.0139
6145 Solute carrier family 22 member 1 SLC22A1 0.0113
3906 Serine dehydratase-like SDSL 0.0033
3908 P-selectin cytoplasmic tail-associated protein pcap 0.0033
3915 Cysteine sulfinic acid decarboxylase-related protein 1 CSAD 0.0033
3914 Alanine-glyoxylate aminotransferase homolog TLH6 0.0033
3883 Ornithine aminotransferase variant Not Available 0.0033
306 Pyridoxal phosphate phosphatase PDXP 0.0033
3911 Uncharacterized protein C20orf38 SPTLC3 0.0033
3910 O-phosphoseryl-tRNA(Sec) selenium transferase SEPSECS 0.0033
3891 Putative L-Dopa decarboxylase DDC 0.0033
3909 Hepatic peroxysomal alanine:glyoxylate aminotransferase Not Available 0.0033
3880 Serine hydroxymethyltransferase 1 Not Available 0.0033
3881 Selenocysteine lyase variant Not Available 0.0033
3878 GAD1 protein GAD1 0.0033
3887 Phosphorylase PYGB 0.0033
3893 DDC protein DDC 0.0033
855 Sphingosine-1-phosphate lyase 1 SGPL1 0.0033
3903 Aminolevulinate, delta-, synthase 2 ALAS2 0.0033
664 Glutamate decarboxylase 2 GAD2 0.0033
3890 Glutamate decarboxylase 2 GAD2 0.0033
3896 CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase GADL1 0.0033
3886 Migration-inducing protein 4 ALAS1 0.0033
3894 KIAA0251 protein PDXDC1 0.0033
3875 Glycogen phosphorylase, brain form PYGB 0.0033
3882 Brain glycogen phosphorylase variant Not Available 0.0033
3905 Molybdenum cofactor sulfurase MOCOS 0.0033
499 Arginine decarboxylase ADC 0.0028
472 Ornithine aminotransferase, mitochondrial OAT 0.0027
435 Kynureninase KYNU 0.0027
4654 Kynureninase kynU 0.0027
3913 Glutamic acid decarboxylase GAD65 0.0027
3874 Proline synthetase co-transcribed bacterial homolog protein PROSC 0.0027
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0027
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0027
420 Glutamate decarboxylase 1 GAD1 0.0027
3900 Glutamate decarboxylase 1 GAD1 0.0027
665 Phosphoserine aminotransferase PSAT1 0.0027
4652 Phosphoserine aminotransferase serC 0.0027
3 Histidine decarboxylase HDC 0.0027
534 Threonine synthase-like 1 THNSL1 0.0027
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0027
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0027
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0027
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.0027
184 L-serine dehydratase SDS 0.0027
491 Serine palmitoyltransferase 1 SPTLC1 0.0027
727 Serine palmitoyltransferase 2 SPTLC2 0.0027
431 Serine racemase SRR 0.0027
89 Cysteine sulfinic acid decarboxylase CSAD 0.0027
868 Cystathionine gamma-lyase CTH 0.0027
426 Aspartate aminotransferase, mitochondrial GOT2 0.0025
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0025
3877 Growth-inhibiting protein 18 GIG18 0.0024
169 Cysteine desulfurase, mitochondrial NFS1 0.0024
3884 SHMT2 protein SHMT2 0.0024
3901 SHMT2 protein SHMT2 0.0024
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0024
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0024
3879 Serine hydroxymethyltransferase 2 Not Available 0.0024
358 Cystathionine beta-synthase CBS 0.0024
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0024
10 Glycogen phosphorylase, liver form PYGL 0.0023
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0023
735 Alanine aminotransferase 1 GPT 0.0023
3904 Alanine aminotransferase 2 GPT2 0.0023
763 Tyrosine aminotransferase TAT 0.0023
5493 Tyrosine aminotransferase Not Available 0.0023
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0022
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0021
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.002
3876 Aromatic-L-amino-acid decarboxylase DDC 0.002
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