DT-Web

DB04299 - Maleic Acid


Identification
Name Maleic Acid
Accession Number DB04299 (EXPT02106)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 116.0722
Groups experimental
Monoisotopic Weight 116.010958616
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Aspartate aminotransferase, cytoplasmic
Name Aspartate aminotransferase, cytoplasmic
Gene Name GOT1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.3134
Aspartate aminotransferase
Name Aspartate aminotransferase
Gene Name aspC
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.4714
Trypanothione reductase
Name Trypanothione reductase
Gene Name TPR
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.3722
Aspartate aminotransferase
Name Aspartate aminotransferase
Gene Name aspC
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.4714
Aromatic-amino-acid aminotransferase
Name Aromatic-amino-acid aminotransferase
Gene Name tyrB
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.7181

Predictions


Id Partner name Gene Name Score
5490 Aspartate aminotransferase Not Available 1.4714
4584 Aminotransferase Not Available 0.1309
894 Alanine racemase alr 0.1092
2453 Alanine racemase alr 0.1092
2744 D-alanine aminotransferase dat 0.0978
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0869
2749 UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase arnB 0.0852
2842 Glutamate-1-semialdehyde 2,1-aminomutase hemL 0.0852
2746 4-aminobutyrate aminotransferase gabT 0.0851
6285 Thermolysin npr 0.0789
2546 Histidinol-phosphate aminotransferase hisC 0.0786
2698 Histidinol-phosphate aminotransferase hisC 0.0786
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0764
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0596
4836 Ferredoxin-dependent glutamate synthase 2 gltS 0.059
4835 CarC carC 0.059
4802 L-cysteine/cystine lyase C-DES c-des 0.0586
3526 Pseudomonalisin pcp 0.0538
6280 T-cell receptor alpha chain C region TRAC 0.05
6281 T-cell receptor beta chain C region TRBC1 0.05
5948 HLA class I histocompatibility antigen, A-2 alpha chain HLA-A 0.05
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0453
6279 Beta-2-microglobulin B2M 0.0436
5353 Glutamate decarboxylase alpha gadA 0.0286
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0253
171 Cysteine dioxygenase CDO-1 0.0243
4064 Probable cysteinyl-tRNA synthetase, mitochondrial CARS2 0.0242
774 Cysteinyl-tRNA synthetase, cytoplasmic CARS 0.0242
1314 Thiamine transporter 2 SLC19A3 0.0242
89 Cysteine sulfinic acid decarboxylase CSAD 0.0238
3877 Growth-inhibiting protein 18 GIG18 0.0238
169 Cysteine desulfurase, mitochondrial NFS1 0.0224
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0218
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0217
358 Cystathionine beta-synthase CBS 0.021
6151 Monocarboxylate transporter 10 SLC16A10 0.0208
868 Cystathionine gamma-lyase CTH 0.02
1999 Methylated-DNA--protein-cysteine methyltransferase MGMT 0.0198
626 Cysteine dioxygenase type 1 CDO1 0.0187
5492 Cystathionine gamma-synthase metB 0.0185
5491 Methionine gamma-lyase mdeA 0.0185
426 Aspartate aminotransferase, mitochondrial GOT2 0.0184
207 Glutathione synthetase GSS 0.0167
5269 Glutathione synthetase gshB 0.0167
1671 Excitatory amino acid transporter 3 SLC1A1 0.0154
2632 Adenylosuccinate synthetase purA 0.015
3323 Adenylosuccinate synthetase purA 0.015
3975 Adenylosuccinate synthetase ADSS 0.015
4598 Adenylosuccinate synthetase Adss 0.015
6817 Adenylosuccinate synthetase purA 0.015
3972 Adenylosuccinate synthetase isozyme 2 ADSS 0.015
209 Aspartoacylase ASPA 0.015
3979 Aspartoacylase-2 ACY3 0.015
533 Aminoacylase-1 ACY1 0.015
3969 Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole- succinocarboxamide synthase PAICS 0.015
799 Aspartyl-tRNA synthetase, cytoplasmic DARS 0.015
3976 Aspartyl-tRNA synthetase, mitochondrial DARS2 0.0149
513 Calcium-binding mitochondrial carrier protein Aralar2 SLC25A13 0.0149
305 Mitochondrial aspartate-glutamate carrier protein SLC25A13 0.0149
262 Calcium-binding mitochondrial carrier protein Aralar1 SLC25A12 0.0149
4823 L-allo-threonine aldolase TM_1744 0.0148
2758 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase bioA 0.0147
449 Ornithine decarboxylase ODC1 0.0143
349 Serine--pyruvate aminotransferase AGXT 0.0138
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0135
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0128
3977 ASRGL1 protein ASRGL1 0.0126
3971 CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase CAD 0.0118
1152 Glycogen phosphorylase, muscle form PYGM 0.0104
740 Argininosuccinate synthase ASS1 0.0102
865 Argininosuccinate synthase ASS1 0.0102
2680 Argininosuccinate synthase argG 0.0102
3194 Argininosuccinate synthase argG 0.0102
1024 Solute carrier family 22 member 11 SLC22A11 0.01
6143 Solute carrier family 22 member 7 SLC22A7 0.0097
3978 Adenylosuccinate synthetase isozyme 1 ADSSL1 0.0094
6142 Solute carrier family 22 member 8 SLC22A8 0.0088
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0082
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0082
665 Phosphoserine aminotransferase PSAT1 0.0082
4652 Phosphoserine aminotransferase serC 0.0082
420 Glutamate decarboxylase 1 GAD1 0.0082
3900 Glutamate decarboxylase 1 GAD1 0.0082
1729 Solute carrier family 22 member 6 SLC22A6 0.008
5682 Ribonuclease pancreatic RNASE1 0.0071
763 Tyrosine aminotransferase TAT 0.007
5493 Tyrosine aminotransferase Not Available 0.007
5109 Outer membrane protein p64k or PM-6 m-6 0.007
3763 5,10-methylenetetrahydrofolate reductase metF 0.007
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.007
5094 5,10-methylenetetrahydrofolate reductase metF 0.007
5122 Mersacidin decarboxylase mrsD 0.007
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.007
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.007
5095 Putidaredoxin reductase camA 0.007
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.007
526 Thioredoxin reductase trxB 0.007
3767 Thioredoxin reductase trxB 0.007
5078 Amine oxidase, flavin-containing PSPTO1126 0.007
5115 FkbI fkbI 0.007
3133 UDP-galactopyranose mutase glf 0.007
5099 UDP-galactopyranose mutase glf 0.007
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.007
5083 Cryptochrome DASH cry 0.007
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.007
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.007
5081 L-aspartate oxidase nadB 0.007
5111 Phenylacetone monooxygenase pamO 0.007
1410 Oxidoreductase HSD17B6 0.007
4725 Oxidoreductase Not Available 0.007
5124 Oxidoreductase Not Available 0.007
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.007
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.007
735 Alanine aminotransferase 1 GPT 0.007
3904 Alanine aminotransferase 2 GPT2 0.007
914 Formimidoyltransferase-cyclodeaminase FTCD 0.007
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0063
4486 Phenol 2-hydroxylase component B pheA2 0.0061
4477 Dihydrolipoyl dehydrogenase lpdV 0.0061
5077 Dihydrolipoyl dehydrogenase Not Available 0.0061
5117 Dihydrolipoyl dehydrogenase lpd 0.0061
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0061
4439 Ferredoxin reductase bphA4 0.0061
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0061
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0061
2470 Pyruvate oxidase pox5 0.0061
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0061
3594 Deoxyribodipyrimidine photo-lyase phr 0.0061
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0061
5080 Deoxyribodipyrimidine photo-lyase phr 0.0061
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0061
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0061
5073 Ferredoxin--NADP reductase petH 0.0061
5076 Ferredoxin--NADP reductase fpr 0.0061
5119 Ferredoxin--NADP reductase petH 0.0061
5121 Ferredoxin--NADP reductase fpr 0.0061
2526 NADPH-ferredoxin reductase fprA fprA 0.0061
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0061
2268 Cholesterol oxidase choB 0.0061
2822 Cholesterol oxidase choA 0.0061
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0061
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0061
5072 N,N-dimethylglycine oxidase dmg 0.0061
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.006
4440 NADH peroxidase npr 0.0056
2893 Glycine oxidase thiO 0.0056
3102 Flavohemoprotein hmp 0.0056
4969 Flavohemoprotein hmp 0.0056
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0056
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0056
2567 Thymidylate synthase thyX thyX 0.0053
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0053
2769 P-hydroxybenzoate hydroxylase pobA 0.0051
2809 P-hydroxybenzoate hydroxylase pobA 0.0051
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.005
1047 Excitatory amino acid transporter 2 SLC1A2 0.005
4026 Aspartyl aminopeptidase DNPEP 0.005
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.005
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.005
1912 Excitatory amino acid transporter 1 SLC1A3 0.005
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.005
4016 Excitatory amino acid transporter 5 SLC1A7 0.005
4019 Excitatory amino acid transporter 4 SLC1A6 0.005
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.005
922 Glutamate receptor 4 GRIA4 0.005
664 Glutamate decarboxylase 2 GAD2 0.005
3890 Glutamate decarboxylase 2 GAD2 0.005
4018 Glutamate receptor delta-2 subunit GRID2 0.005
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.005
927 Metabotropic glutamate receptor 8 GRM8 0.005
925 Metabotropic glutamate receptor 4 GRM4 0.005
926 Metabotropic glutamate receptor 7 GRM7 0.005
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.005
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.005
4020 Glutamyl aminopeptidase ENPEP 0.005
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.005
4017 5-oxoprolinase OPLAH 0.005
4027 Glutamate receptor delta-1 subunit GRID1 0.005
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.005
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.005
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.005
327 Glutathione reductase gor 0.0049
5110 Glutathione reductase GR2 0.0049
2380 Monomeric sarcosine oxidase soxA 0.0049
126 D-lactate dehydrogenase dld 0.0049
3545 D-lactate dehydrogenase Not Available 0.0049
4510 D-lactate dehydrogenase ldhA 0.0049
605 Fumarate reductase flavoprotein subunit frdA 0.0048
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0048
3673 Fumarate reductase flavoprotein subunit fccA 0.0048
4912 Fumarate reductase flavoprotein subunit ifcA 0.0048
6549 Fumarate reductase flavoprotein subunit frdA 0.0048
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0047
6645 D-amino-acid oxidase DAO 0.0046
3914 Alanine-glyoxylate aminotransferase homolog TLH6 0.0044
3909 Hepatic peroxysomal alanine:glyoxylate aminotransferase Not Available 0.0044
3881 Selenocysteine lyase variant Not Available 0.0044
3887 Phosphorylase PYGB 0.0044
3908 P-selectin cytoplasmic tail-associated protein pcap 0.0044
3915 Cysteine sulfinic acid decarboxylase-related protein 1 CSAD 0.0044
306 Pyridoxal phosphate phosphatase PDXP 0.0044
3911 Uncharacterized protein C20orf38 SPTLC3 0.0044
3906 Serine dehydratase-like SDSL 0.0044
3891 Putative L-Dopa decarboxylase DDC 0.0044
3880 Serine hydroxymethyltransferase 1 Not Available 0.0044
3893 DDC protein DDC 0.0044
3883 Ornithine aminotransferase variant Not Available 0.0044
3910 O-phosphoseryl-tRNA(Sec) selenium transferase SEPSECS 0.0044
3882 Brain glycogen phosphorylase variant Not Available 0.0044
855 Sphingosine-1-phosphate lyase 1 SGPL1 0.0044
3905 Molybdenum cofactor sulfurase MOCOS 0.0044
3903 Aminolevulinate, delta-, synthase 2 ALAS2 0.0044
3896 CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase GADL1 0.0044
3886 Migration-inducing protein 4 ALAS1 0.0044
3878 GAD1 protein GAD1 0.0044
3894 KIAA0251 protein PDXDC1 0.0044
3875 Glycogen phosphorylase, brain form PYGB 0.0044
5 Glutaminase liver isoform, mitochondrial GLS2 0.0043
917 Glutaminase kidney isoform, mitochondrial GLS 0.0043
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0042
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0042
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0042
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0042
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0042
5261 Phosphoribosylformylglycinamidine synthase purL 0.0042
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0042
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0041
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.0041
625 Glutamate carboxypeptidase 2 FOLH1 0.0041
184 L-serine dehydratase SDS 0.004
431 Serine racemase SRR 0.004
491 Serine palmitoyltransferase 1 SPTLC1 0.004
727 Serine palmitoyltransferase 2 SPTLC2 0.004
534 Threonine synthase-like 1 THNSL1 0.004
3874 Proline synthetase co-transcribed bacterial homolog protein PROSC 0.0039
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0039
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0039
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0039
3 Histidine decarboxylase HDC 0.0039
499 Arginine decarboxylase ADC 0.0039
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0039
435 Kynureninase KYNU 0.0038
4654 Kynureninase kynU 0.0038
916 Metabotropic glutamate receptor 1 GRM1 0.0037
714 Glutathione reductase, mitochondrial GSR 0.0037
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0037
3913 Glutamic acid decarboxylase GAD65 0.0036
472 Ornithine aminotransferase, mitochondrial OAT 0.0036
923 Glutamate receptor 3 GRIA3 0.0036
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0036
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0036
76 Nitric-oxide synthase, brain NOS1 0.0035
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0035
3879 Serine hydroxymethyltransferase 2 Not Available 0.0035
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0035
3884 SHMT2 protein SHMT2 0.0035
3901 SHMT2 protein SHMT2 0.0035
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0035
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0035
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0035
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0035
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0034
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0033
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0033
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0032
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0031
4120 NADPH--cytochrome P450 reductase POR 0.0031
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0031
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0031
705 Glutamate receptor 1 GRIA1 0.003
33 Cystine/glutamate transporter SLC7A11 0.003
3426 Glutamine synthetase glnA 0.003
3987 Glutamine synthetase GLUL 0.003
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0029
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0029
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0028
3939 Amine oxidase [flavin-containing] B MAOB 0.0027
10 Glycogen phosphorylase, liver form PYGL 0.0027
3947 Xanthine dehydrogenase/oxidase XDH 0.0026
738 Monocarboxylate transporter 1 SLC16A1 0.0024
3941 Amine oxidase [flavin-containing] A MAOA 0.0024
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0023
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0023
921 Glutamate receptor 2 GRIA2 0.0021
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