DT-Web

DB00172 - L-Proline


Identification
Name L-Proline
Accession Number DB00172 (NUTR00047)
Type small molecule
Description A non-essential amino acid that is synthesized from glutamic acid. It is an essential component of collagen and is important for proper functioning of joints and tendons. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 115.1305
Groups approved
Monoisotopic Weight 115.063328537
Pharmacology
Indication L-Proline is extremely important for the proper functioning of joints and tendons and also helps maintain and strengthen heart muscles.
Mechanism of action Glycogenic, by L-Proline oxidase in the kidney, it is ring-opened and is oxidized to form L-Glutamic acid. L-Ornithine and L-Glutamic acid are converted to L-Proline via L-Glutamic acid-gamma-semialdehyde. It is contained abundantly in collagen, and is intimately involved in the function of arthrosis and chordae.
Absorption Not Available
Protein binding Not Available
Biotransformation Hepatic
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Prolyl 4-hydroxylase subunit alpha-2
Name Prolyl 4-hydroxylase subunit alpha-2
Gene Name P4HA2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8621
Proline oxidase, mitochondrial
Name Proline oxidase, mitochondrial
Gene Name PRODH
Pharmacological action unknown
Actions Not Available
References
  • Huang TC, Huang YW, Hung HJ, Ho CT, Wu ML: Delta1-pyrroline-5-carboxylic acid formed by proline dehydrogenase from the Bacillus subtilis ssp. natto expressed in Escherichia coli as a precursor for 2-acetyl-1-pyrroline. J Agric Food Chem. 2007 Jun 27;55(13):5097-102. Epub 2007 May 31. - Pubmed
  • White TA, Krishnan N, Becker DF, Tanner JJ: Structure and kinetics of monofunctional proline dehydrogenase from Thermus thermophilus. J Biol Chem. 2007 May 11;282(19):14316-27. Epub 2007 Mar 7. - Pubmed
  • White TA, Tanner JJ: Cloning, purification and crystallization of Thermus thermophilus proline dehydrogenase. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Aug 1;61(Pt 8):737-9. Epub 2005 Jul 8. - Pubmed
DTHybrid score 0.982
Peptidyl-prolyl cis-trans isomerase H
Name Peptidyl-prolyl cis-trans isomerase H
Gene Name PPIH
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9867
Proline synthetase co-transcribed bacterial homolog protein
Name Proline synthetase co-transcribed bacterial homolog protein
Gene Name PROSC
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7196
Prolyl 4-hydroxylase subunit alpha-1
Name Prolyl 4-hydroxylase subunit alpha-1
Gene Name P4HA1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8398
Peptidyl-prolyl cis-trans isomerase B
Name Peptidyl-prolyl cis-trans isomerase B
Gene Name PPIB
Pharmacological action unknown
Actions binder
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.7637
Peptidyl-prolyl cis-trans isomerase, mitochondrial
Name Peptidyl-prolyl cis-trans isomerase, mitochondrial
Gene Name PPIF
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8689
Peptidyl-prolyl cis-trans isomerase C
Name Peptidyl-prolyl cis-trans isomerase C
Gene Name PPIC
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9892
Peptidyl-prolyl cis-trans isomerase A
Name Peptidyl-prolyl cis-trans isomerase A
Gene Name PPIA
Pharmacological action unknown
Actions binder
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 1.564
Peptidyl-prolyl cis-trans isomerase G
Name Peptidyl-prolyl cis-trans isomerase G
Gene Name PPIG
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9828
Prolyl 3-hydroxylase 1
Name Prolyl 3-hydroxylase 1
Gene Name LEPRE1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7974
Pyrroline 5-carboxylate reductase isoform
Name Pyrroline 5-carboxylate reductase isoform
Gene Name P5CR2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9917
Probable prolyl-tRNA synthetase, mitochondrial
Name Probable prolyl-tRNA synthetase, mitochondrial
Gene Name PARS2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.982
Prolyl 3-hydroxylase 2
Name Prolyl 3-hydroxylase 2
Gene Name LEPREL1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7975
Prolyl 3-hydroxylase 3
Name Prolyl 3-hydroxylase 3
Gene Name LEPREL2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7971
Pyrroline-5-carboxylate reductase 3
Name Pyrroline-5-carboxylate reductase 3
Gene Name PYCRL
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
Chromosome 14 open reading frame 149
Name Chromosome 14 open reading frame 149
Gene Name C14orf149
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9822
Pyrroline-5-carboxylate reductase 1
Name Pyrroline-5-carboxylate reductase 1
Gene Name PYCR1
Pharmacological action unknown
Actions Not Available
References
  • Huang TC, Huang YW, Hung HJ, Ho CT, Wu ML: Delta1-pyrroline-5-carboxylic acid formed by proline dehydrogenase from the Bacillus subtilis ssp. natto expressed in Escherichia coli as a precursor for 2-acetyl-1-pyrroline. J Agric Food Chem. 2007 Jun 27;55(13):5097-102. Epub 2007 May 31. - Pubmed
  • Hu CA, Donald SP, Yu J, Lin WW, Liu Z, Steel G, Obie C, Valle D, Phang JM: Overexpression of proline oxidase induces proline-dependent and mitochondria-mediated apoptosis. Mol Cell Biochem. 2007 Jan;295(1-2):85-92. Epub 2006 Jul 28. - Pubmed
  • Meng Z, Lou Z, Liu Z, Hui D, Bartlam M, Rao Z: Purification, characterization, and crystallization of human pyrroline-5-carboxylate reductase. Protein Expr Purif. 2006 Sep;49(1):83-7. Epub 2006 Mar 20. - Pubmed
DTHybrid score 0.733
Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase
Name Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase
Gene Name EPRS
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.5524
Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
Name Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)
Gene Name SLC6A14
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8676
Sodium-dependent proline transporter
Name Sodium-dependent proline transporter
Gene Name SLC6A7
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.982
Pyrroline-5-carboxylate reductase 2
Name Pyrroline-5-carboxylate reductase 2
Gene Name PYCR2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Murahama M, Yoshida T, Hayashi F, Ichino T, Sanada Y, Wada K: Purification and characterization of Delta(1)-pyrroline-5-carboxylate reductase isoenzymes, indicating differential distribution in spinach (Spinacia oleracea L.) leaves. Plant Cell Physiol. 2001 Jul;42(7):742-50. - Pubmed
DTHybrid score 0.7362

Enzymes


Proline oxidase, mitochondrial
Name Proline oxidase, mitochondrial
Gene Name PRODH
Actions substrate
References
  • -
  • Phang JM, Donald SP, Pandhare J, Liu Y: The metabolism of proline, a stress substrate, modulates carcinogenic pathways. Amino Acids. 2008 Nov;35(4):681-90. Epub 2008 Apr 10. - Pubmed
  • Phang JM, Liu W, Zabirnyk O: Proline metabolism and microenvironmental stress. Annu Rev Nutr. 2010 Aug 21;30:441-63. - Pubmed
DTHybrid score 0.982

Transporters


Monocarboxylate transporter 10
Name Monocarboxylate transporter 10
Gene Name SLC16A10
Actions inhibitor
References
  • Kim DK, Kanai Y, Chairoungdua A, Matsuo H, Cha SH, Endou H: Expression cloning of a Na+-independent aromatic amino acid transporter with structural similarity to H+/monocarboxylate transporters. J Biol Chem. 2001 May 18;276(20):17221-8. Epub 2001 Feb 20. - Pubmed
DTHybrid score 0.7336

Predictions


Id Partner name Gene Name Score
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 1.564
3938 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 PLOD3 0.1562
3940 Gamma-butyrobetaine dioxygenase BBOX1 0.1561
3964 Trimethyllysine dioxygenase, mitochondrial TMLHE 0.1561
97 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 0.1561
2921 Histone deacetylase 8 HDAC8 0.138
391 Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial SUCLG2 0.1071
1410 Oxidoreductase HSD17B6 0.1071
4725 Oxidoreductase Not Available 0.1071
5124 Oxidoreductase Not Available 0.1071
4009 Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial SUCLA2 0.1071
4010 Mitochondrial dicarboxylate carrier SLC25A10 0.1071
4007 Succinate receptor 1 SUCNR1 0.1071
4002 Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial SUCLG1 0.1071
498 Solute carrier family 13 member 2 SLC13A2 0.1071
4008 Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial OXCT2 0.1071
25 Solute carrier family 13 member 1 SLC13A1 0.107
673 Solute carrier family 13 member 3 SLC13A3 0.107
5469 Head decoration protein shp 0.1031
1483 Membrane copper amine oxidase AOC3 0.0982
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0955
4003 Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial OXCT1 0.0835
3839 Phytanoyl-CoA dioxygenase, peroxisomal PHYH 0.0803
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0784
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0783
3948 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 ALKBH2 0.0772
3962 Egl nine homolog 3 EGLN3 0.0771
3956 Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 ALKBH3 0.0771
3966 Putative HIF-prolyl hydroxylase PH-4 P4HTM 0.0771
3946 Hypothetical protein DKFZp686H15154 OGFOD2 0.0771
3954 Egl nine homolog 2 EGLN2 0.0771
3953 2-oxoglutarate and iron-dependent oxygenase domain containing 1 OGFOD1 0.0771
189 Solute carrier family 23 member 1 SLC23A1 0.0771
3935 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 PLOD2 0.0771
3958 Jumonji/ARID domain-containing protein 1D KDM5D 0.077
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0761
4006 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC 0.0725
4001 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 0.0725
3999 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SDHD 0.0666
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0653
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.0628
6508 Putative uncharacterized protein srtB 0.0611
6543 Putative uncharacterized protein tcp14 0.0611
6615 Putative uncharacterized protein MT0785 0.0611
6623 Putative uncharacterized protein Not Available 0.0611
6806 Putative uncharacterized protein AGR_C_2535 0.0611
6813 Putative uncharacterized protein SAV4671 0.0611
6815 Putative uncharacterized protein AFE_1514 0.0611
6819 Putative uncharacterized protein RUMGNA_03254 0.0611
6825 Putative uncharacterized protein CV_3270 0.0611
2704 Outer-membrane lipoprotein lolB lolB 0.0611
6805 Outer-membrane lipoprotein lolB lolB 0.0611
6808 Transcriptional regulator, GntR family BCE_3424 0.0611
4579 Serine acetyltransferase cysE 0.0611
6807 Serine acetyltransferase cysE 0.0611
6809 ABC transporter, periplasmic substrate-binding protein SPO2066 0.061
6810 Transketolase tkt2 0.061
6142 Solute carrier family 22 member 8 SLC22A8 0.0582
3943 Peptidyl-glycine alpha-amidating monooxygenase PAM 0.057
3960 Egl nine homolog 1 EGLN1 0.057
482 Glycine receptor subunit alpha-1 GLRA1 0.0553
6804 Profilin-2 PFN2 0.0532
153 Dopamine beta-hydroxylase DBH 0.051
2485 Hyaluronate lyase SP_0314 0.0469
3172 Hyaluronate lyase hylB 0.0469
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0455
6847 Lactase-phlorizin hydrolase LCT 0.0448
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0446
2245 Xylose isomerase xylA 0.0444
2253 Xylose isomerase xylA 0.0444
2260 Xylose isomerase xylA 0.0444
2431 Xylose isomerase xylA 0.0444
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0427
1566 Corticoliberin CRH 0.0413
509 Thymidine kinase TK 0.0405
570 Thymidine kinase TK 0.0405
2559 Thymidine kinase TK 0.0405
3430 Thymidine kinase tdk 0.0405
3518 Thymidine kinase TK 0.0405
5301 Thymidine kinase tdk 0.0405
5771 Thymidine kinase ORF36 0.0405
7009 Thymidine kinase ORF36 0.0405
4512 Cytochrome P450 3A4 CYP3A4 0.0369
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0358
5669 50S ribosomal protein L27 rpmA 0.0354
5670 Organic hydroperoxide resistance protein ohr 0.0354
5675 Chaperone protein torD torD 0.0354
5672 Molybdenum cofactor biosynthesis protein A moaA 0.0353
5410 Unsaturated glucuronyl hydrolase ugl 0.0353
5676 Axin-1 AXIN1 0.0353
5673 C protein alpha-antigen bca 0.0353
338 DNA polymerase UL30 0.0345
379 DNA polymerase UL54 0.0345
697 DNA polymerase ORF28 0.0345
2482 DNA polymerase 43 0.0345
4104 DNA polymerase BALF5 0.0345
191 Peptide methionine sulfoxide reductase MSRA 0.0335
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0317
3125 Protease synthase and sporulation negative regulatory protein PAI 1 paiA 0.0308
6579 Calcium/calmodulin-dependent protein kinase type II alpha chain CAMK2A 0.0308
3317 Holo-[acyl-carrier-protein] synthase acpS 0.0308
4381 Holo-[acyl-carrier-protein] synthase acpS 0.0308
2636 Shikimate dehydrogenase aroE 0.0308
3515 Shikimate dehydrogenase aroE 0.0308
611 Retinal dehydrogenase 1 ALDH1A1 0.0301
3191 Histidinol dehydrogenase hisD 0.0285
2532 Pantoate--beta-alanine ligase panC 0.0285
2280 Listeriolysin regulatory protein prfA 0.0284
4811 Amylosucrase ams 0.0284
909 Maleylacetoacetate isomerase GSTZ1 0.0282
763 Tyrosine aminotransferase TAT 0.0274
5493 Tyrosine aminotransferase Not Available 0.0274
199 Monocarboxylate transporter 8 SLC16A2 0.0258
6645 D-amino-acid oxidase DAO 0.0245
534 Threonine synthase-like 1 THNSL1 0.0241
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.024
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.024
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.024
5925 Neuropeptide Y NPY 0.0231
314 System N amino acid transporter 1 SLC38A3 0.0229
1729 Solute carrier family 22 member 6 SLC22A6 0.0228
2314 Triosephosphate isomerase TPI 0.0221
3417 Triosephosphate isomerase tpiA 0.0221
3443 Triosephosphate isomerase tpiA 0.0221
6346 Triosephosphate isomerase TPI1 0.0221
301 Kynurenine--oxoglutarate transaminase 1 CCBL1 0.0216
3 Histidine decarboxylase HDC 0.0205
24 Thymidylate synthase TMP1 0.0199
359 Thymidylate synthase TYMS 0.0199
2626 Thymidylate synthase thyA 0.0199
2729 Thymidylate synthase thyA 0.0199
5352 Thymidylate synthase THYA 0.0199
4069 Threonyl-tRNA synthetase, mitochondrial TARS2 0.0197
261 Threonyl-tRNA synthetase, cytoplasmic TARS 0.0197
246 Valyl-tRNA synthetase VARS 0.0196
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0183
358 Cystathionine beta-synthase CBS 0.0182
349 Serine--pyruvate aminotransferase AGXT 0.018
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0179
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0167
184 L-serine dehydratase SDS 0.0164
431 Serine racemase SRR 0.0164
491 Serine palmitoyltransferase 1 SPTLC1 0.0164
727 Serine palmitoyltransferase 2 SPTLC2 0.0164
169 Cysteine desulfurase, mitochondrial NFS1 0.0161
2457 Bacillolysin nprS 0.016
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.016
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0159
601 Propionyl-CoA carboxylase beta chain, mitochondrial PCCB 0.0157
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0157
735 Alanine aminotransferase 1 GPT 0.0151
3904 Alanine aminotransferase 2 GPT2 0.0151
676 Tyrosine 3-monooxygenase TH 0.0149
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0148
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0148
815 Histidyl-tRNA synthetase, cytoplasmic HARS 0.0147
96 Histidine ammonia-lyase HAL 0.0147
6257 Histidine ammonia-lyase Not Available 0.0147
6536 Histidine ammonia-lyase hutH 0.0147
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0147
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0147
3877 Growth-inhibiting protein 18 GIG18 0.0145
38 Cystinosin CTNS 0.0141
3998 B(0,+)-type amino acid transporter 1 SLC7A9 0.0141
1963 Neutral and basic amino acid transport protein rBAT SLC3A1 0.0141
426 Aspartate aminotransferase, mitochondrial GOT2 0.014
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0139
150 Cationic amino acid transporter 3 SLC7A3 0.0137
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.0137
58 Cationic amino acid transporter 4 SLC7A4 0.0137
499 Arginine decarboxylase ADC 0.0137
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0134
665 Phosphoserine aminotransferase PSAT1 0.0134
4652 Phosphoserine aminotransferase serC 0.0134
420 Glutamate decarboxylase 1 GAD1 0.0134
3900 Glutamate decarboxylase 1 GAD1 0.0134
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0134
3899 Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 0.0133
6141 Sodium/bile acid cotransporter SLC10A1 0.0131
33 Cystine/glutamate transporter SLC7A11 0.013
89 Cysteine sulfinic acid decarboxylase CSAD 0.0128
399 Tyrosyl-tRNA synthetase, mitochondrial YARS2 0.0127
626 Cysteine dioxygenase type 1 CDO1 0.0125
3977 ASRGL1 protein ASRGL1 0.0121
435 Kynureninase KYNU 0.012
4654 Kynureninase kynU 0.012
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0119
263 Neutral amino acid transporter B(0) SLC1A5 0.0119
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0118
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0116
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0114
701 Isoleucine-tRNA synthetase IARS 0.011
546 Isoleucyl-tRNA synthetase, cytoplasmic IARS 0.011
4080 Isoleucyl-tRNA synthetase, mitochondrial IARS2 0.011
221 Lysyl-tRNA synthetase KARS 0.0109
3911 Uncharacterized protein C20orf38 SPTLC3 0.0108
3881 Selenocysteine lyase variant Not Available 0.0108
3887 Phosphorylase PYGB 0.0108
3915 Cysteine sulfinic acid decarboxylase-related protein 1 CSAD 0.0108
3914 Alanine-glyoxylate aminotransferase homolog TLH6 0.0108
3903 Aminolevulinate, delta-, synthase 2 ALAS2 0.0108
3883 Ornithine aminotransferase variant Not Available 0.0108
306 Pyridoxal phosphate phosphatase PDXP 0.0108
3906 Serine dehydratase-like SDSL 0.0108
3896 CDNA FLJ46802 fis, clone TRACH3032150, moderately similar to Cysteine sulfinic acid decarboxylase GADL1 0.0108
3891 Putative L-Dopa decarboxylase DDC 0.0108
3909 Hepatic peroxysomal alanine:glyoxylate aminotransferase Not Available 0.0108
3878 GAD1 protein GAD1 0.0108
3908 P-selectin cytoplasmic tail-associated protein pcap 0.0108
3893 DDC protein DDC 0.0108
3880 Serine hydroxymethyltransferase 1 Not Available 0.0108
3910 O-phosphoseryl-tRNA(Sec) selenium transferase SEPSECS 0.0108
855 Sphingosine-1-phosphate lyase 1 SGPL1 0.0108
3886 Migration-inducing protein 4 ALAS1 0.0108
3894 KIAA0251 protein PDXDC1 0.0108
3875 Glycogen phosphorylase, brain form PYGB 0.0108
3882 Brain glycogen phosphorylase variant Not Available 0.0108
3905 Molybdenum cofactor sulfurase MOCOS 0.0108
4092 Probable asparaginyl-tRNA synthetase, mitochondrial NARS2 0.0107
669 Asparaginyl-tRNA synthetase, cytoplasmic NARS 0.0107
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0105
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0105
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0105
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0105
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0105
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0105
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0105
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0105
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0105
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0105
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0105
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0105
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0105
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0105
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0105
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0105
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0105
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0105
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0105
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0105
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0105
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0105
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0105
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0105
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0105
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0105
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0105
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0105
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0105
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0105
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0105
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0105
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0105
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0105
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0105
644 Heme oxygenase 2 HMOX2 0.0105
4982 Heme oxygenase 2 pbsA2 0.0105
729 GDP-L-fucose synthetase TSTA3 0.0105
3463 GDP-L-fucose synthetase fcl 0.0105
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0105
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0105
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0105
206 3-keto-steroid reductase HSD17B7 0.0105
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0105
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0105
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0105
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0105
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0105
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0105
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0105
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0105
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0105
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0105
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0105
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0105
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0105
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0105
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0105
711 UDP-glucose 6-dehydrogenase UGDH 0.0105
3672 UDP-glucose 6-dehydrogenase hasB 0.0105
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0105
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0105
107 C-4 methylsterol oxidase SC4MOL 0.0105
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0105
3726 D-3-phosphoglycerate dehydrogenase serA 0.0105
4291 D-3-phosphoglycerate dehydrogenase serA 0.0105
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0105
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0105
643 Peroxisomal bifunctional enzyme EHHADH 0.0105
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0105
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0105
167 L-lactate dehydrogenase C chain LDHC 0.0105
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0105
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0105
34 7-dehydrocholesterol reductase DHCR7 0.0105
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0105
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0105
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0105
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0105
575 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT 0.0104
455 5-aminolevulinate synthase, nonspecific, mitochondrial ALAS1 0.0104
681 Glycine dehydrogenase [decarboxylating], mitochondrial GLDC 0.0104
868 Cystathionine gamma-lyase CTH 0.0104
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0103
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0103
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0103
816 Biliverdin reductase A BLVRA 0.0103
738 Monocarboxylate transporter 1 SLC16A1 0.0102
5650 NimA-related protein DR_0842 0.0101
72 Seryl-tRNA synthetase, cytoplasmic SARS 0.0099
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0098
501 Leucine carboxyl methyltransferase 1 LCMT1 0.0097
675 Leucine carboxyl methyltransferase 2 LCMT2 0.0097
846 Leucyl-tRNA synthetase, cytoplasmic LARS 0.0097
227 Probable leucyl-tRNA synthetase, mitochondrial LARS2 0.0097
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0096
42 Phenylalanyl-tRNA synthetase alpha chain FARSA 0.0096
6602 Phenylalanyl-tRNA synthetase alpha chain pheS 0.0096
31 Phenylalanyl-tRNA synthetase, mitochondrial FARS2 0.0096
618 Phenylalanyl-tRNA synthetase beta chain FARSB 0.0096
6603 Phenylalanyl-tRNA synthetase beta chain pheT 0.0096
619 Low-affinity cationic amino acid transporter 2 SLC7A2 0.0095
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0094
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0093
828 Phenylalanine-4-hydroxylase PAH 0.0092
3109 Phenylalanine-4-hydroxylase phhA 0.0092
3884 SHMT2 protein SHMT2 0.0092
3901 SHMT2 protein SHMT2 0.0092
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0092
3879 Serine hydroxymethyltransferase 2 Not Available 0.0092
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0092
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0089
256 Tyrosyl-tRNA synthetase, cytoplasmic YARS 0.0089
646 Malate dehydrogenase, cytoplasmic MDH1 0.0089
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0088
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0088
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0087
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0087
500 Monocarboxylate transporter 4 SLC16A3 0.0087
666 NADP-dependent malic enzyme ME1 0.0087
396 Alcohol dehydrogenase 4 ADH4 0.0086
489 Monocarboxylate transporter 2 SLC16A7 0.0086
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0086
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0085
328 Sorbitol dehydrogenase SORD 0.0085
597 Dihydropteridine reductase QDPR 0.0085
3913 Glutamic acid decarboxylase GAD65 0.0085
6026 Alcohol dehydrogenase 6 ADH6 0.0084
3426 Glutamine synthetase glnA 0.0083
3987 Glutamine synthetase GLUL 0.0083
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0083
857 Malate dehydrogenase, mitochondrial MDH2 0.0082
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0082
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0081
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0081
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0081
627 11-cis retinol dehydrogenase RDH5 0.0081
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0081
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.008
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0079
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0078
6148 Multidrug resistance-associated protein 7 ABCC10 0.0078
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0077
12 Alcohol dehydrogenase class 3 ADH5 0.0077
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0077
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0077
77 L-lactate dehydrogenase B chain LDHB 0.0077
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0076
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0076
569 Retinal dehydrogenase 2 ALDH1A2 0.0076
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0075
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0075
917 Glutaminase kidney isoform, mitochondrial GLS 0.0075
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0075
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0075
5 Glutaminase liver isoform, mitochondrial GLS2 0.0075
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0075
5261 Phosphoribosylformylglycinamidine synthase purL 0.0075
833 Organic cation/carnitine transporter 1 SLC22A4 0.0075
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0074
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0074
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0074
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0074
472 Ornithine aminotransferase, mitochondrial OAT 0.0074
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0074
13 Aminomethyltransferase, mitochondrial AMT 0.0073
90 Tryptophan 5-hydroxylase 2 TPH2 0.0073
4063 Tryptophanyl-tRNA synthetase, mitochondrial WARS2 0.0073
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0072
473 L-lactate dehydrogenase A chain LDHA 0.0072
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0072
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0071
203 Pyridoxine-5'-phosphate oxidase PNPO 0.0071
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.007
1588 Multidrug resistance protein 1 ABCB1 0.007
1671 Excitatory amino acid transporter 3 SLC1A1 0.0069
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0069
776 Bile salt export pump ABCB11 0.0068
279 Tyrosinase TYR 0.0068
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0067
740 Argininosuccinate synthase ASS1 0.0067
865 Argininosuccinate synthase ASS1 0.0067
2680 Argininosuccinate synthase argG 0.0067
3194 Argininosuccinate synthase argG 0.0067
594 Thyroxine-binding globulin SERPINA7 0.0066
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0065
251 Alcohol dehydrogenase 1A ADH1A 0.0065
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0064
862 Multidrug resistance-associated protein 1 ABCC1 0.0063
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0063
449 Ornithine decarboxylase ODC1 0.0062
4119 Cytochrome P450 2D6 CYP2D6 0.0062
4924 Cytochrome P450 2C8 CYP2C8 0.0062
758 Thyroid hormone receptor alpha THRA 0.0061
654 Flavin reductase BLVRB 0.006
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0059
252 Tryptophanyl-tRNA synthetase, cytoplasmic WARS 0.0059
765 Indoleamine 2,3-dioxygenase IDO1 0.0059
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0059
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0059
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0058
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0058
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0058
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0058
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0058
4016 Excitatory amino acid transporter 5 SLC1A7 0.0058
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0058
4026 Aspartyl aminopeptidase DNPEP 0.0058
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0058
664 Glutamate decarboxylase 2 GAD2 0.0058
3890 Glutamate decarboxylase 2 GAD2 0.0058
4027 Glutamate receptor delta-1 subunit GRID1 0.0058
1912 Excitatory amino acid transporter 1 SLC1A3 0.0058
4019 Excitatory amino acid transporter 4 SLC1A6 0.0058
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0058
1047 Excitatory amino acid transporter 2 SLC1A2 0.0058
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0058
4020 Glutamyl aminopeptidase ENPEP 0.0058
922 Glutamate receptor 4 GRIA4 0.0058
926 Metabotropic glutamate receptor 7 GRM7 0.0058
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0058
4018 Glutamate receptor delta-2 subunit GRID2 0.0058
927 Metabotropic glutamate receptor 8 GRM8 0.0058
925 Metabotropic glutamate receptor 4 GRM4 0.0058
4017 5-oxoprolinase OPLAH 0.0058
532 Neutral amino acid transporter A SLC1A4 0.0057
4070 Probable alanyl-tRNA synthetase, mitochondrial AARS2 0.0057
323 Alanyl-tRNA synthetase, cytoplasmic AARS 0.0057
2452 Tryptophanyl-tRNA synthetase trpS 0.0056
810 Heme oxygenase 1 HMOX1 0.0056
3391 Heme oxygenase 1 pbsA1 0.0056
444 Alcohol dehydrogenase 1B ADH1B 0.0056
380 Cytochrome P450 17A1 CYP17A1 0.0055
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0055
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0055
134 Tryptophan 5-hydroxylase 1 TPH1 0.0055
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0054
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0054
346 Thyroid hormone receptor beta-1 THRB 0.0054
6012 Tryptophan 2,3-dioxygenase TDO2 0.0053
714 Glutathione reductase, mitochondrial GSR 0.0053
171 Cysteine dioxygenase CDO-1 0.0053
774 Cysteinyl-tRNA synthetase, cytoplasmic CARS 0.0052
1314 Thiamine transporter 2 SLC19A3 0.0052
4064 Probable cysteinyl-tRNA synthetase, mitochondrial CARS2 0.0052
625 Glutamate carboxypeptidase 2 FOLH1 0.0052
468 Cytochrome P450 4A11 CYP4A11 0.0052
207 Glutathione synthetase GSS 0.0052
5269 Glutathione synthetase gshB 0.0052
10 Glycogen phosphorylase, liver form PYGL 0.0052
6107 Cytochrome P450 3A7 CYP3A7 0.0051
834 Arginase-2, mitochondrial ARG2 0.0051
593 Proton-coupled amino acid transporter 1 SLC36A1 0.0051
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0051
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0051
6020 Aldehyde oxidase AOX1 0.005
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.005
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.005
577 Argininosuccinate lyase ASL 0.0049
4118 Cytochrome P450 3A5 CYP3A5 0.0049
3971 CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase CAD 0.0049
480 Methionine-R-sulfoxide reductase B2 MSRB2 0.0048
317 Methionine-R-sulfoxide reductase SEPX1 0.0048
3996 Betaine--homocysteine S-methyltransferase 2 BHMT2 0.0048
3921 Methionine adenosyltransferase 2 subunit beta MAT2B 0.0048
3995 Methionyl-tRNA synthetase, mitochondrial MARS2 0.0048
600 Methionyl-tRNA synthetase, cytoplasmic MARS 0.0048
916 Metabotropic glutamate receptor 1 GRM1 0.0047
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0047
517 Alcohol dehydrogenase 1C ADH1C 0.0047
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0047
6016 Cytochrome P450 2C19 CYP2C19 0.0046
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0046
923 Glutamate receptor 3 GRIA3 0.0046
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0045
3947 Xanthine dehydrogenase/oxidase XDH 0.0045
4757 Cytochrome P450 2C9 CYP2C9 0.0044
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0044
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0043
1999 Methylated-DNA--protein-cysteine methyltransferase MGMT 0.0043
822 Aldose reductase AKR1B1 0.0042
365 Dihydrofolate reductase DHFR 0.0042
2381 Dihydrofolate reductase DFR1 0.0042
2833 Dihydrofolate reductase Not Available 0.0042
2931 Dihydrofolate reductase folA 0.0042
3544 Dihydrofolate reductase folA 0.0042
3682 Dihydrofolate reductase folA 0.0042
6642 Dihydrofolate reductase folA 0.0042
6756 Dihydrofolate reductase dfrA 0.0042
397 Monocarboxylate transporter 3 SLC16A8 0.0041
218 Monocarboxylate transporter 5 SLC16A4 0.0041
195 Monocarboxylate transporter 7 SLC16A6 0.0041
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0041
429 Monocarboxylate transporter 6 SLC16A5 0.0041
373 Transthyretin TTR 0.004
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.004
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0039
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0039
1152 Glycogen phosphorylase, muscle form PYGM 0.0039
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0038
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0036
705 Glutamate receptor 1 GRIA1 0.0036
52 Pyruvate kinase isozymes R/L PKLR 0.0035
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0035
771 Pyruvate carboxylase, mitochondrial PC 0.0034
1517 Beta-3 adrenergic receptor ADRB3 0.0034
840 Methionine synthase reductase, mitochondrial MTRR 0.0033
163 D(1B) dopamine receptor DRD5 0.0032
98 Pyruvate kinase isozymes M1/M2 PKM2 0.0032
2632 Adenylosuccinate synthetase purA 0.0031
3323 Adenylosuccinate synthetase purA 0.0031
3975 Adenylosuccinate synthetase ADSS 0.0031
4598 Adenylosuccinate synthetase Adss 0.0031
6817 Adenylosuccinate synthetase purA 0.0031
3972 Adenylosuccinate synthetase isozyme 2 ADSS 0.0031
533 Aminoacylase-1 ACY1 0.0031
3969 Multifunctional protein ADE2 [Includes: Phosphoribosylaminoimidazole- succinocarboxamide synthase PAICS 0.0031
799 Aspartyl-tRNA synthetase, cytoplasmic DARS 0.0031
209 Aspartoacylase ASPA 0.0031
3979 Aspartoacylase-2 ACY3 0.0031
3976 Aspartyl-tRNA synthetase, mitochondrial DARS2 0.0031
513 Calcium-binding mitochondrial carrier protein Aralar2 SLC25A13 0.0031
305 Mitochondrial aspartate-glutamate carrier protein SLC25A13 0.0031
262 Calcium-binding mitochondrial carrier protein Aralar1 SLC25A12 0.0031
809 Methionine synthase MTR 0.0031
2935 Methionine synthase metH 0.0031
432 D(4) dopamine receptor DRD4 0.003
587 Serum albumin ALB 0.003
638 D(3) dopamine receptor DRD3 0.0029
7 Nitric oxide synthase, inducible NOS2 0.0029
1008 CTP synthase 1 CTPS 0.0029
3988 Protein-glutamine gamma-glutamyltransferase K TGM1 0.0029
3985 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] 2 GFPT2 0.0029
3990 Protein-glutamine gamma-glutamyltransferase 4 TGM4 0.0029
3986 Protein-glutamine gamma-glutamyltransferase 6 TGM6 0.0029
3992 Protein-glutamine gamma-glutamyltransferase Z TGM7 0.0029
3983 Protein-glutamine gamma-glutamyltransferase 5 TGM5 0.0029
3989 Glutaminyl-tRNA synthetase QARS 0.0029
291 Nitric-oxide synthase, endothelial NOS3 0.0029
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0028
921 Glutamate receptor 2 GRIA2 0.0028
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0028
2795 Methionine aminopeptidase 2 METAP2 0.0026
23 D(1A) dopamine receptor DRD1 0.0026
3917 Methylenetetrahydrofolate reductase MTHFR 0.0026
789 Alpha-1D adrenergic receptor ADRA1D 0.0026
378 Alpha-2C adrenergic receptor ADRA2C 0.0025
831 D(2) dopamine receptor DRD2 0.0024
1596 Protein-glutamine gamma-glutamyltransferase 2 TGM2 0.0024
629 Alpha-2B adrenergic receptor ADRA2B 0.0024
118 Organic cation/carnitine transporter 2 SLC22A5 0.0024
193 Beta-1 adrenergic receptor ADRB1 0.0024
6 Coagulation factor XIII A chain F13A1 0.0024
766 Beta-2 adrenergic receptor ADRB2 0.0023
632 Alpha-1B adrenergic receptor ADRA1B 0.0023
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0023
413 Amidophosphoribosyltransferase PPAT 0.0023
2515 Amidophosphoribosyltransferase purF 0.0023
3714 Amidophosphoribosyltransferase purF 0.0023
4058 Glycine N-acyltransferase-like protein 2 GLYATL2 0.0022
4057 Glycine N-acyltransferase GLYAT 0.0022
4059 Glycine N-acyltransferase-like protein 1 GLYATL1 0.0022
4056 N-arachidonyl glycine receptor GPR18 0.0022
4061 Peroxisomal sarcosine oxidase PIPOX 0.0022
4055 Bile acid CoA:amino acid N-acyltransferase BAAT 0.0022
1236 Sodium- and chloride-dependent glycine transporter 1 SLC6A9 0.0022
4062 Sodium- and chloride-dependent glycine transporter 2 SLC6A5 0.0022
4060 Vesicular inhibitory amino acid transporter SLC32A1 0.0022
1088 5-aminolevulinate synthase, erythroid-specific, mitochondrial ALAS2 0.0022
1466 Glycyl-tRNA synthetase GARS 0.0022
318 Alpha-2A adrenergic receptor ADRA2A 0.0022
3978 Adenylosuccinate synthetase isozyme 1 ADSSL1 0.0021
556 Alpha-1A adrenergic receptor ADRA1A 0.002
2339 Protein-glutamine gamma-glutamyltransferase E TGM3 0.002
4054 Glycine cleavage system H protein, mitochondrial GCSH 0.0017
62 Glycine receptor subunit beta GLRB 0.0017
383 Glycine amidinotransferase, mitochondrial GATM 0.0016
411 Glycine N-methyltransferase GNMT 0.0016
5682 Ribonuclease pancreatic RNASE1 0.0016
820 Glycine receptor subunit alpha-2 GLRA2 0.0014
461 Glycine receptor subunit alpha-3 GLRA3 0.0014
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