DT-Web

DB01199 - Tubocurarine


Identification
Name Tubocurarine
Accession Number DB01199 (APRD00176)
Type small molecule
Description A neuromuscular blocker and active ingredient in curare; plant based alkaloid of Menispermaceae. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 609.7312
Groups approved
Monoisotopic Weight 609.296462054
Pharmacology
Indication Used as a diagnosis agent for myasthenia gravis, and also to facilitate the intubation after induction of anesthesia in surgical procedure
Mechanism of action Tubocurarine, the chief alkaloid in tobacco products, binds stereo-selectively to nicotinic-cholinergic receptors at the autonomic ganglia, in the adrenal medulla, at neuromuscular junctions, and in the brain. Two types of central nervous system effects are believed to be the basis of Tubocurarine's positively reinforcing properties. A stimulating effect is exerted mainly in the cortex via the locus ceruleus and a reward effect is exerted in the limbic system. At low doses the stimulant effects predominate while at high doses the reward effects predominate. Intermittent intravenous administration of Tubocurarine activates neurohormonal pathways, releasing acetylcholine, norepinephrine, dopamine, serotonin, vasopressin, beta-endorphin, growth hormone, and ACTH.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Amikacin The agent increases the effect of muscle relaxant
Aminophylline Theophylline decreases the effect of muscle relaxant
Azathioprine The agent decreases the effect of the muscle relaxant
Carbamazepine Decreases the effect of muscle relaxant
Clindamycin The agent increases the effect of muscle relaxant
Fosphenytoin Phenytoin decreases the effect of muscle relaxant
Gentamicin The agent increases the effect of muscle relaxant
Lincomycin The agent increases the effect of muscle relaxant
Mercaptopurine The agent dereases the effect of the muscle relaxant
Netilmicin The agent increases the effect of muscle relaxant
Oxtriphylline Theophylline decreases the effect of muscle relaxant
Phenytoin Phenytoin decreases the effect of the muscle relaxant
Piperacillin The agent increases the effect of the muscle relaxant
Theophylline Theophylline decreases the effect of the muscle relaxant
Tobramycin The agent increases the effect of the muscle relaxant
Food Interactions Not Available

Targets


Neuronal acetylcholine receptor subunit alpha-2
Name Neuronal acetylcholine receptor subunit alpha-2
Gene Name CHRNA2
Pharmacological action yes
Actions antagonist
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Wenningmann I, Dilger JP: The kinetics of inhibition of nicotinic acetylcholine receptors by (+)-tubocurarine and pancuronium. Mol Pharmacol. 2001 Oct;60(4):790-6. - Pubmed
  • Nishimura K, Kitamura Y, Taniguchi T, Agata K: Analysis of motor function modulated by cholinergic neurons in planarian Dugesia japonica. Neuroscience. 2010 Jun 16;168(1):18-30. Epub 2010 Mar 23. - Pubmed
  • Jonsson Fagerlund M, Dabrowski M, Eriksson LI: Pharmacological characteristics of the inhibition of nondepolarizing neuromuscular blocking agents at human adult muscle nicotinic acetylcholine receptor. Anesthesiology. 2009 Jun;110(6):1244-52. - Pubmed
  • Liu M, Dilger JP: Synergy between pairs of competitive antagonists at adult human muscle acetylcholine receptors. Anesth Analg. 2008 Aug;107(2):525-33. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.6357
5-hydroxytryptamine 3 receptor
Name 5-hydroxytryptamine 3 receptor
Gene Name HTR3A
Pharmacological action yes
Actions antagonist
References
  • Hefft S, Hulo S, Bertrand D, Muller D: Synaptic transmission at nicotinic acetylcholine receptors in rat hippocampal organotypic cultures and slices. J Physiol. 1999 Mar 15;515 ( Pt 3):769-76. - Pubmed
  • Yan D, White MM: Interaction of d-tubocurarine analogs with mutant 5-HT(3) receptors. Neuropharmacology. 2002 Sep;43(3):367-73. - Pubmed
  • Yan D, Meyer JK, White MM: Mapping residues in the ligand-binding domain of the 5-HT(3) receptor onto d-tubocurarine structure. Mol Pharmacol. 2006 Aug;70(2):571-8. Epub 2006 May 24. - Pubmed
  • Peters JA, Malone HM, Lambert JJ: Antagonism of 5-HT3 receptor mediated currents in murine N1E-115 neuroblastoma cells by (+)-tubocurarine. Neurosci Lett. 1990 Mar 2;110(1-2):107-12. - Pubmed
  • Emerit MB, Riad M, Fattaccini CM, Hamon M: Characteristics of [14C]guanidinium accumulation in NG 108-15 cells exposed to serotonin 5-HT3 receptor ligands and substance P. J Neurochem. 1993 Jun;60(6):2059-67. - Pubmed
DTHybrid score 0.231
Acetylcholinesterase
Name Acetylcholinesterase
Gene Name ACHE
Pharmacological action unknown
Actions inhibitor
References
  • Radic Z, Taylor P: The influence of peripheral site ligands on the reaction of symmetric and chiral organophosphates with wildtype and mutant acetylcholinesterases. Chem Biol Interact. 1999 May 14;119-120:111-7. - Pubmed
  • Golicnik M, Fournier D, Stojan J: Acceleration of Drosophila melanogaster acetylcholinesterase methanesulfonylation: peripheral ligand D-tubocurarine enhances the affinity for small methanesulfonylfluoride. Chem Biol Interact. 2002 Feb 20;139(2):145-57. - Pubmed
  • Radic Z, Taylor P: Peripheral site ligands accelerate inhibition of acetylcholinesterase by neutral organophosphates. J Appl Toxicol. 2001 Dec;21 Suppl 1:S13-4. - Pubmed
  • Gupta RC, Dettbarn WD: Potential of memantine, D-tubocurarine, and atropine in preventing acute toxic myopathy induced by organophosphate nerve agents: soman, sarin, tabun and VX. Neurotoxicology. 1992 Fall;13(3):649-61. - Pubmed
  • Bianchi DA, Hirschmann GS, Theoduloz C, Bracca AB, Kaufman TS: Synthesis of tricyclic analogs of stephaoxocanidine and their evaluation as acetylcholinesterase inhibitors. Bioorg Med Chem Lett. 2005 Jun 2;15(11):2711-5. - Pubmed
DTHybrid score 1.0521

Transporters


Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions substrate
References
  • Busch AE, Quester S, Ulzheimer JC, Waldegger S, Gorboulev V, Arndt P, Lang F, Koepsell H: Electrogenic properties and substrate specificity of the polyspecific rat cation transporter rOCT1. J Biol Chem. 1996 Dec 20;271(51):32599-604. - Pubmed
DTHybrid score 0.3187
Solute carrier family 22 member 2
Name Solute carrier family 22 member 2
Gene Name SLC22A2
Actions Not Available
References
  • Gorboulev V, Ulzheimer JC, Akhoundova A, Ulzheimer-Teuber I, Karbach U, Quester S, Baumann C, Lang F, Busch AE, Koepsell H: Cloning and characterization of two human polyspecific organic cation transporters. DNA Cell Biol. 1997 Jul;16(7):871-81. - Pubmed
DTHybrid score 0.2371

Predictions


Id Partner name Gene Name Score
3923 Cholinesterase BCHE 0.2085
617 Muscarinic acetylcholine receptor M2 CHRM2 0.1405
4119 Cytochrome P450 2D6 CYP2D6 0.1188
4512 Cytochrome P450 3A4 CYP3A4 0.101
1588 Multidrug resistance protein 1 ABCB1 0.0841
4200 Cytochrome P450 1A2 CYP1A2 0.0681
6147 Solute carrier family 22 member 3 SLC22A3 0.0635
118 Organic cation/carnitine transporter 2 SLC22A5 0.0608
4757 Cytochrome P450 2C9 CYP2C9 0.0599
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0494
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0482
6016 Cytochrome P450 2C19 CYP2C19 0.0467
4118 Cytochrome P450 3A5 CYP3A5 0.0464
833 Organic cation/carnitine transporter 1 SLC22A4 0.0458
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0371
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.036
502 5-hydroxytryptamine 2A receptor HTR2A 0.0352
713 Sodium-dependent dopamine transporter SLC6A3 0.0341
6107 Cytochrome P450 3A7 CYP3A7 0.0331
5259 Transcriptional regulator ntrC1 0.0327
6699 Transcriptional regulator Cgl2612 0.0327
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0325
6142 Solute carrier family 22 member 8 SLC22A8 0.031
556 Alpha-1A adrenergic receptor ADRA1A 0.029
6013 Cytochrome P450 2E1 CYP2E1 0.0278
4264 Alpha-L-fucosidase, putative TM_0306 0.0278
831 D(2) dopamine receptor DRD2 0.0268
6024 Cytochrome P450 1A1 CYP1A1 0.0266
378 Alpha-2C adrenergic receptor ADRA2C 0.0243
23 D(1A) dopamine receptor DRD1 0.0241
318 Alpha-2A adrenergic receptor ADRA2A 0.0239
492 Histamine H1 receptor HRH1 0.0239
6030 Cytochrome P450 2B6 CYP2B6 0.0237
766 Beta-2 adrenergic receptor ADRB2 0.0237
320 5-hydroxytryptamine 1A receptor HTR1A 0.023
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.023
4924 Cytochrome P450 2C8 CYP2C8 0.0224
629 Alpha-2B adrenergic receptor ADRA2B 0.0218
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0218
632 Alpha-1B adrenergic receptor ADRA1B 0.0215
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0214
1729 Solute carrier family 22 member 6 SLC22A6 0.0213
6794 Uncharacterized lipoprotein ybbD ybbD 0.0213
2662 Glutamate racemase murI 0.0213
6299 Glutamate racemase murI 0.0213
6641 Glutamate racemase murI 0.0213
6771 Glutamate racemase murI 0.0213
6892 Glutamate racemase murI 0.0213
6795 Phosphoenolpyruvate-protein phosphotransferase ptsP 0.0213
435 Kynureninase KYNU 0.0213
4654 Kynureninase kynU 0.0213
3454 Esterase estA 0.0212
193 Beta-1 adrenergic receptor ADRB1 0.0203
723 Cytosolic phospholipase A2 PLA2G4A 0.0197
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0195
5718 Cytochrome P450 2A6 CYP2A6 0.0188
824 Sodium-dependent serotonin transporter SLC6A4 0.0185
590 5-hydroxytryptamine 2C receptor HTR2C 0.0182
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0177
885 5-hydroxytryptamine 1B receptor HTR1B 0.0177
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0167
587 Serum albumin ALB 0.0165
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0164
6010 Thiamine transporter 1 SLC19A2 0.0159
776 Bile salt export pump ABCB11 0.0156
2517 Subtilisin BPN' apr 0.0155
862 Multidrug resistance-associated protein 1 ABCC1 0.0154
124 Histamine H2 receptor HRH2 0.0152
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0144
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0144
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0144
6143 Solute carrier family 22 member 7 SLC22A7 0.0143
175 Thiamin pyrophosphokinase 1 TPK1 0.0142
432 D(4) dopamine receptor DRD4 0.014
131 Synaptic vesicular amine transporter SLC18A2 0.0138
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0137
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0137
638 D(3) dopamine receptor DRD3 0.0136
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0133
163 D(1B) dopamine receptor DRD5 0.0132
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.013
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0128
672 Prostaglandin F2-alpha receptor PTGFR 0.0125
94 5-hydroxytryptamine 4 receptor HTR4 0.0125
4773 Deoxycytidine kinase DCK 0.0124
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0124
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0123
789 Alpha-1D adrenergic receptor ADRA1D 0.0121
528 5-hydroxytryptamine 1E receptor HTR1E 0.0121
1024 Solute carrier family 22 member 11 SLC22A11 0.0121
696 Kappa-type opioid receptor OPRK1 0.0119
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0117
725 5-hydroxytryptamine 1D receptor HTR1D 0.0116
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0116
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0116
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0113
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0112
1256 5-hydroxytryptamine 6 receptor HTR6 0.0112
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0111
847 Mu-type opioid receptor OPRM1 0.0109
7 Nitric oxide synthase, inducible NOS2 0.0109
3939 Amine oxidase [flavin-containing] B MAOB 0.0101
716 5-hydroxytryptamine 7 receptor HTR7 0.0101
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.01
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0099
509 Thymidine kinase TK 0.0097
570 Thymidine kinase TK 0.0097
2559 Thymidine kinase TK 0.0097
3430 Thymidine kinase tdk 0.0097
3518 Thymidine kinase TK 0.0097
5301 Thymidine kinase tdk 0.0097
5771 Thymidine kinase ORF36 0.0097
7009 Thymidine kinase ORF36 0.0097
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0096
6148 Multidrug resistance-associated protein 7 ABCC10 0.0095
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0094
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0089
6070 Nischarin NISCH 0.0089
1898 Cytochrome P450 1B1 CYP1B1 0.0088
3176 Trypsin-1 PRSS1 0.0086
694 Matrix protein 2 M 0.0086
3941 Amine oxidase [flavin-containing] A MAOA 0.0085
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0085
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0085
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0084
4203 Histamine N-methyltransferase HNMT 0.0083
164 Histamine H4 receptor HRH4 0.0082
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0081
2472 Voltage-gated potassium channel kcsA 0.0081
6366 Voltage-gated potassium channel kcsA 0.0081
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0081
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0079
1830 5'-nucleotidase NT5E 0.0077
2164 Multidrug resistance-associated protein 4 ABCC4 0.0077
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0077
125 DNA polymerase beta POLB 0.0074
338 DNA polymerase UL30 0.0073
379 DNA polymerase UL54 0.0073
697 DNA polymerase ORF28 0.0073
2482 DNA polymerase 43 0.0073
4104 DNA polymerase BALF5 0.0073
6106 Cytochrome P450 2C18 CYP2C18 0.0073
3626 Probable polysaccharide deacetylase pdaA pdaA 0.0071
6171 Solute carrier family 28 member 3 SLC28A3 0.007
467 Delta-type opioid receptor OPRD1 0.0069
828 Phenylalanine-4-hydroxylase PAH 0.0068
3109 Phenylalanine-4-hydroxylase phhA 0.0068
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0068
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0068
3560 Gentamicin 3'-acetyltransferase aacC1 0.0067
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0067
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0066
6137 Multidrug resistance-associated protein 6 ABCC6 0.0065
3611 Cytidine deaminase cdd 0.0065
3707 Cytidine deaminase cdd 0.0065
4211 Cytidine deaminase CDA 0.0065
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0065
5126 Arginase rocF 0.0064
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0064
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0063
6136 Multidrug resistance-associated protein 5 ABCC5 0.0061
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.006
1341 Histamine H3 receptor HRH3 0.006
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.006
319 Opioid receptor, sigma 1 OPRS1 0.006
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0059
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0059
4787 Envelope glycoprotein gp160 env 0.0059
4820 Envelope glycoprotein gp160 env 0.0059
5727 Envelope glycoprotein gp160 env 0.0059
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0058
6014 Cytochrome P450 2A13 CYP2A13 0.0058
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0058
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0058
6111 DNA polymerase epsilon subunit 4 POLE4 0.0058
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0058
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0058
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0058
6112 DNA polymerase epsilon subunit 3 POLE3 0.0058
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0058
6110 DNA polymerase epsilon subunit 2 POLE2 0.0058
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0058
740 Argininosuccinate synthase ASS1 0.0058
865 Argininosuccinate synthase ASS1 0.0058
2680 Argininosuccinate synthase argG 0.0058
3194 Argininosuccinate synthase argG 0.0058
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0057
3926 Choline transporter-like protein 2 SLC44A2 0.0057
861 Choline kinase alpha CHKA 0.0057
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0057
1686 Choline transporter-like protein 1 SLC44A1 0.0057
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0057
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0057
700 Choline dehydrogenase, mitochondrial CHDH 0.0057
3927 Choline transporter-like protein 3 SLC44A3 0.0057
3925 Choline transporter-like protein 4 SLC44A4 0.0057
769 High-affinity choline transporter 1 SLC5A7 0.0057
576 Choline O-acetyltransferase CHAT 0.0057
3922 Phospholipase D2 PLD2 0.0057
3924 Phospholipase D1 PLD1 0.0057
1373 Glucosylceramidase GBA 0.0056
4666 Fucose-binding lectin PA-IIL lecB 0.0056
477 DNA topoisomerase 4 subunit A parC 0.0056
886 DNA topoisomerase 4 subunit A parC 0.0056
6226 DNA topoisomerase 4 subunit A parC 0.0056
404 DNA gyrase subunit A gyrA 0.0055
6224 DNA gyrase subunit A gyrA 0.0055
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0055
436 5-hydroxytryptamine 2B receptor HTR2B 0.0055
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0055
1770 Phospholipase C PLCL1 0.0055
2841 Phospholipase C plc 0.0055
6141 Sodium/bile acid cotransporter SLC10A1 0.0055
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0054
3140 Hemagglutinin-neuraminidase HN 0.0054
3609 Hemagglutinin-neuraminidase HN 0.0054
3811 Cytochrome P450 19A1 CYP19A1 0.0053
756 Sex hormone-binding globulin SHBG 0.0053
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0052
738 Monocarboxylate transporter 1 SLC16A1 0.0052
1517 Beta-3 adrenergic receptor ADRB3 0.0051
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0051
144 Hemoglobin subunit alpha HBA1 0.0051
624 Guanidinoacetate N-methyltransferase GAMT 0.005
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.005
136 Estrogen receptor ESR1 0.005
3947 Xanthine dehydrogenase/oxidase XDH 0.0049
6165 Copper-transporting ATPase 1 ATP7A 0.0049
6163 Copper-transporting ATPase 2 ATP7B 0.0049
174 Sigma 1-type opioid receptor SIGMAR1 0.0048
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0048
731 HIV-1 protease HIV-1 protease 0.0047
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0047
6146 High affinity copper uptake protein 1 SLC31A1 0.0047
976 Platelet glycoprotein IX GP9 0.0046
303 Diamine acetyltransferase 2 SAT2 0.0045
623 Spermine oxidase SMOX 0.0045
1317 Spermine synthase SMS 0.0045
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0045
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0045
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0045
908 Glutathione S-transferase theta-1 GSTT1 0.0044
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0044
465 Calmodulin CALM1 0.0044
342 P protein [Includes: DNA-directed DNA polymerase P 0.0044
612 P protein [Includes: DNA-directed DNA polymerase P 0.0044
20 Prostaglandin G/H synthase 1 PTGS1 0.0043
603 DNA polymerase alpha catalytic subunit POLA1 0.0043
904 Glutathione S-transferase P GSTP1 0.0043
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.0043
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0041
6432 Transporter snf 0.0041
1178 Adenosine A2a receptor ADORA2A 0.004
123 Diamine acetyltransferase 1 SAT1 0.004
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.004
817 DNA topoisomerase 2-alpha TOP2A 0.004
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0039
896 Glutathione S-transferase Mu 1 GSTM1 0.0039
869 Estrogen receptor beta ESR2 0.0039
5626 Nucleoside diphosphate kinase B NME2 0.0038
4785 Ig gamma-1 chain C region IGHG1 0.0038
702 UMP-CMP kinase CMPK1 0.0037
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0037
527 Prostacyclin receptor PTGIR 0.0036
2300 Lysozyme E 0.0036
3633 Lysozyme R 0.0036
5597 Lysozyme 17 0.0036
6167 Organic solute transporter subunit beta OSTB 0.0036
6166 Organic solute transporter subunit alpha OSTA 0.0036
5682 Ribonuclease pancreatic RNASE1 0.0036
1757 Myeloperoxidase MPO 0.0036
1074 Urokinase-type plasminogen activator PLAU 0.0036
1864 RET proto-oncogene RET 0.0034
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0033
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0033
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0033
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0033
277 Purine nucleoside phosphorylase PNP 0.0033
2870 Purine nucleoside phosphorylase punA 0.0033
2945 Purine nucleoside phosphorylase punA 0.0033
4659 Purine nucleoside phosphorylase TM_1596 0.0033
4825 Purine nucleoside phosphorylase TTHA1435 0.0033
2251 Thymidylate kinase tmk 0.0033
2254 Thymidylate kinase DTYMK 0.0033
3522 Thymidylate kinase tmk 0.0033
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
244 Angiotensin-converting enzyme ACE 0.0032
153 Dopamine beta-hydroxylase DBH 0.0031
2257 Uridine phosphorylase udp 0.0031
5132 Uridine phosphorylase udp 0.0031
449 Ornithine decarboxylase ODC1 0.0031
6212 Tubulin gamma-1 chain TUBG1 0.0031
6210 Tubulin delta chain TUBD1 0.0031
6211 Tubulin epsilon chain TUBE1 0.0031
5294 Nucleoside diphosphate kinase A NME1 0.003
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.003
6218 Pannexin-1 PANX1 0.003
751 Potassium channel subfamily K member 6 KCNK6 0.003
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0028
1360 Sphingomyelin phosphodiesterase SMPD1 0.0028
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0027
1618 High affinity nerve growth factor receptor NTRK1 0.0027
172 Potassium channel subfamily K member 1 KCNK1 0.0027
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0027
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0026
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0026
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0026
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0026
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0026
3810 Catechol O-methyltransferase COMT 0.0025
228 Beta platelet-derived growth factor receptor PDGFRB 0.0025
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0025
4217 Telomerase reverse transcriptase TERT 0.0024
6149 Solute carrier family 22 member 10 SLC22A10 0.0024
380 Cytochrome P450 17A1 CYP17A1 0.0024
1629 Transcription factor AP-1 JUN 0.0024
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0023
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0023
504 Mast/stem cell growth factor receptor KIT 0.0023
737 Mineralocorticoid receptor NR3C2 0.0022
2449 Tubulin alpha-3 chain TUBA1A 0.0022
161 Tubulin beta chain TUBB 0.0021
312 Tubulin beta chain TUB2 0.0021
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.002
614 Progesterone receptor PGR 0.002
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0019
6085 Fatty acid-binding protein, intestinal FABP2 0.0019
489 Monocarboxylate transporter 2 SLC16A7 0.0019
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0019
4192 DNA topoisomerase 2-beta TOP2B 0.0019
2320 Thymidine kinase, cytosolic TK1 0.0018
5449 Hypothetical gliding protein mglB 0.0018
5443 UPF0189 protein ymdB ymdB 0.0018
5440 UPF0067 protein yebR yebR 0.0018
5439 33 kDa chaperonin hslO 0.0018
3781 Thiol:disulfide interchange protein dsbC precursor dsbC 0.0018
2720 Copper-containing nitrite reductase nirK 0.0018
4705 Manganese catalase Not Available 0.0018
332 Beta-lactamase blaZ 0.0018
2478 Beta-lactamase ampC 0.0018
2613 Beta-lactamase ampC 0.0018
2635 Beta-lactamase ampC 0.0018
2700 Beta-lactamase penP 0.0018
5445 Beta-lactamase blaB 0.0018
6019 Beta-lactamase SHV-7 0.0018
6701 Beta-lactamase cphA 0.0018
5448 Ribonuclease Z rnz 0.0018
5446 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase HI_1679 0.0018
5447 Lethal(3)malignant brain tumor-like protein L3MBTL1 0.0018
5454 Internalin-A inlA 0.0018
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0017
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0017
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0017
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0017
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0017
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0017
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0017
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0017
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0017
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0017
4498 Ornithine cyclodeaminase PP3533 0.0017
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0017
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0016
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0016
4120 NADPH--cytochrome P450 reductase POR 0.0016
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0016
5450 Prolyl endopeptidase Pep pep 0.0016
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0016
3356 Diaminopimelate decarboxylase lysA 0.0015
4771 Dissimilatory copper-containing nitrite reductase nir 0.0015
2714 Chorismate mutase aroH 0.0015
4611 Chorismate mutase aroG 0.0015
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0015
3274 Hydroxylamine reductase hcp 0.0015
4804 Hydroxylamine reductase hcp 0.0015
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0015
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0015
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0015
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0015
3462 Tyrosine-protein kinase transforming protein Abl ABL 0.0014
3399 Limonene-1,2-epoxide hydrolase limA 0.0014
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.0014
597 Dihydropteridine reductase QDPR 0.0014
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0014
5180 L(+)-mandelate dehydrogenase mdlB 0.0014
3500 Putative family 31 glucosidase yicI yicI 0.0014
4608 Putative cytochrome P450 SCO1207 0.0013
4963 Putative cytochrome P450 SCO2884 0.0013
6254 Putative cytochrome P450 SCO6998 0.0013
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0013
3480 Mannan endo-1,4-beta-mannosidase manA 0.0013
1615 Chymase CMA1 0.0013
577 Argininosuccinate lyase ASL 0.0013
2597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] glmS 0.0012
365 Dihydrofolate reductase DHFR 0.0012
2381 Dihydrofolate reductase DFR1 0.0012
2833 Dihydrofolate reductase Not Available 0.0012
2931 Dihydrofolate reductase folA 0.0012
3544 Dihydrofolate reductase folA 0.0012
3682 Dihydrofolate reductase folA 0.0012
6642 Dihydrofolate reductase folA 0.0012
6756 Dihydrofolate reductase dfrA 0.0012
3587 Gastrotropin FABP6 0.0012
468 Cytochrome P450 4A11 CYP4A11 0.0012
287 Beta-1,4-galactosyltransferase 1 B4GALT1 0.0012
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.001
33 Cystine/glutamate transporter SLC7A11 0.001
6031 Cytochrome P450 3A43 CYP3A43 0.0009
290 Prostaglandin G/H synthase 2 PTGS2 0.0008
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0007
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0007
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0007
146 Androgen receptor AR 0.0007
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0007
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0007
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0007
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0006
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0006
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0006
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0006
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0006
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0005
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