DT-Web

DB04133 - Degraded Cephaloridine


Identification
Name Degraded Cephaloridine
Accession Number DB04133 (EXPT00884)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 340.418
Groups experimental
Monoisotopic Weight 340.05514839
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Beta-lactamase
Name Beta-lactamase
Gene Name blaZ
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.7163
Penicillin-binding proteins 1A/1B
Name Penicillin-binding proteins 1A/1B
Gene Name pbpA
Pharmacological action yes
Actions inhibitor
References
  • Powell JK, Young KD: Lysis of Escherichia coli by beta-lactams which bind penicillin-binding proteins 1a and 1b: inhibition by heat shock proteins. J Bacteriol. 1991 Jul;173(13):4021-6. - Pubmed
DTHybrid score 0.8137

Transporters


Organic cation/carnitine transporter 2
Name Organic cation/carnitine transporter 2
Gene Name SLC22A5
Actions Not Available
References
  • Ganapathy ME, Huang W, Rajan DP, Carter AL, Sugawara M, Iseki K, Leibach FH, Ganapathy V: beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. J Biol Chem. 2000 Jan 21;275(3):1699-707. - Pubmed
DTHybrid score 0.277
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions Not Available
References
  • Khamdang S, Takeda M, Babu E, Noshiro R, Onozato ML, Tojo A, Enomoto A, Huang XL, Narikawa S, Anzai N, Piyachaturawat P, Endou H: Interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics. Eur J Pharmacol. 2003 Mar 28;465(1-2):1-7. - Pubmed
DTHybrid score 0.4731
Solute carrier family 22 member 8
Name Solute carrier family 22 member 8
Gene Name SLC22A8
Actions Not Available
References
  • Khamdang S, Takeda M, Babu E, Noshiro R, Onozato ML, Tojo A, Enomoto A, Huang XL, Narikawa S, Anzai N, Piyachaturawat P, Endou H: Interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics. Eur J Pharmacol. 2003 Mar 28;465(1-2):1-7. - Pubmed
DTHybrid score 0.3675
Solute carrier family 22 member 11
Name Solute carrier family 22 member 11
Gene Name SLC22A11
Actions Not Available
References
  • Khamdang S, Takeda M, Babu E, Noshiro R, Onozato ML, Tojo A, Enomoto A, Huang XL, Narikawa S, Anzai N, Piyachaturawat P, Endou H: Interaction of human and rat organic anion transporter 2 with various cephalosporin antibiotics. Eur J Pharmacol. 2003 Mar 28;465(1-2):1-7. - Pubmed
DTHybrid score 0.2881

Predictions


Id Partner name Gene Name Score
2478 Beta-lactamase ampC 0.7163
2613 Beta-lactamase ampC 0.7163
2635 Beta-lactamase ampC 0.7163
2700 Beta-lactamase penP 0.7163
5445 Beta-lactamase blaB 0.7163
6019 Beta-lactamase SHV-7 0.7163
6701 Beta-lactamase cphA 0.7163
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.165
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.1649
6143 Solute carrier family 22 member 7 SLC22A7 0.1283
2858 Beta-lactamase TEM bla 0.099
6396 Beta-lactamase TEM bla 0.099
587 Serum albumin ALB 0.088
4512 Cytochrome P450 3A4 CYP3A4 0.0793
645 Penicillin-binding protein 1A mrcA 0.0775
5805 Penicillin-binding protein 1A ponA 0.0775
6185 Penicillin-binding protein 1A mrcA 0.0775
6799 Penicillin-binding protein 1A pbpA 0.0775
543 Penicillin-binding protein 1B mrcB 0.0717
6186 Penicillin-binding protein 1B ponB 0.0717
6822 Penicillin-binding protein 1b pbp1b 0.0717
6844 Penicillin-binding protein 1b pbp1b 0.0717
867 Penicillin-binding protein 3 pbpC 0.0705
6119 Penicillin-binding protein 3 pbp3 0.0705
7154 Penicillin-binding protein 3 pbp3 0.0705
7157 Penicillin-binding protein 3 LMHCC_2184 0.0705
7162 Penicillin-binding protein 3 pbpB 0.0705
7172 Penicillin-binding protein 3 pbp3 0.0705
833 Organic cation/carnitine transporter 1 SLC22A4 0.0649
6145 Solute carrier family 22 member 1 SLC22A1 0.0586
6144 Solute carrier family 22 member 2 SLC22A2 0.0581
4757 Cytochrome P450 2C9 CYP2C9 0.0557
290 Prostaglandin G/H synthase 2 PTGS2 0.0548
1588 Multidrug resistance protein 1 ABCB1 0.0546
1 Peptidoglycan synthetase ftsI ftsI 0.0541
4155 Peptidoglycan synthetase ftsI ftsI 0.0541
20 Prostaglandin G/H synthase 1 PTGS1 0.0528
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0523
2164 Multidrug resistance-associated protein 4 ABCC4 0.0493
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.044
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0432
4200 Cytochrome P450 1A2 CYP1A2 0.041
6016 Cytochrome P450 2C19 CYP2C19 0.0406
4119 Cytochrome P450 2D6 CYP2D6 0.0404
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0385
4924 Cytochrome P450 2C8 CYP2C8 0.0379
862 Multidrug resistance-associated protein 1 ABCC1 0.0372
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0365
22 30S ribosomal protein S4 rpsD 0.0357
6714 30S ribosomal protein S4 rpsD 0.0357
6147 Solute carrier family 22 member 3 SLC22A3 0.0351
738 Monocarboxylate transporter 1 SLC16A1 0.035
140 30S ribosomal protein S9 rpsI 0.0336
6719 30S ribosomal protein S9 rpsI 0.0336
6725 30S ribosomal protein S9 rpsI 0.0336
404 DNA gyrase subunit A gyrA 0.0314
6224 DNA gyrase subunit A gyrA 0.0314
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0295
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.026
1757 Myeloperoxidase MPO 0.0254
438 Taste receptor type 1 member 2 TAS1R2 0.0248
776 Bile salt export pump ABCB11 0.0247
477 DNA topoisomerase 4 subunit A parC 0.0242
886 DNA topoisomerase 4 subunit A parC 0.0242
6226 DNA topoisomerase 4 subunit A parC 0.0242
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0236
3686 Acyl-CoA thioesterase I precursor tesA 0.0222
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0221
338 DNA polymerase UL30 0.0216
379 DNA polymerase UL54 0.0216
697 DNA polymerase ORF28 0.0216
2482 DNA polymerase 43 0.0216
4104 DNA polymerase BALF5 0.0216
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0215
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0213
819 Penicillin-binding protein 4 dacB 0.0209
6141 Sodium/bile acid cotransporter SLC10A1 0.0208
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0208
4118 Cytochrome P450 3A5 CYP3A5 0.0205
6136 Multidrug resistance-associated protein 5 ABCC5 0.0202
6067 Penicillin binding protein 2a mecA 0.0201
887 DNA gyrase subunit B gyrB 0.0201
4150 DNA gyrase subunit B gyrB 0.0201
6225 DNA gyrase subunit B gyrB 0.0201
2016 Dipeptidase 1 DPEP1 0.0197
6024 Cytochrome P450 1A1 CYP1A1 0.0195
558 Solute carrier family 12 member 1 SLC12A1 0.0194
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.0192
357 Carbonic anhydrase 2 CA2 0.0189
5353 Glutamate decarboxylase alpha gadA 0.0183
6113 MecA PBP2' (penicillin binding protein 2') mecA 0.0182
817 DNA topoisomerase 2-alpha TOP2A 0.0174
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0171
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.017
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.017
6149 Solute carrier family 22 member 10 SLC22A10 0.0168
2385 Penicillin acylase Not Available 0.0166
592 Carbonic anhydrase 4 CA4 0.0159
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0154
159 Penicillin-binding protein 2B penA 0.0154
6121 Penicillin-binding protein 2B penA 0.0154
295 Carbonic anhydrase 1 CA1 0.015
2261 Major NAD(P)H-flavin oxidoreductase Not Available 0.0149
5718 Cytochrome P450 2A6 CYP2A6 0.0147
4252 Penicillin-binding protein 5 dacA 0.0145
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
6107 Cytochrome P450 3A7 CYP3A7 0.0142
124 Histamine H2 receptor HRH2 0.0141
1867 Major prion protein PRNP 0.0139
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0139
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0134
6013 Cytochrome P450 2E1 CYP2E1 0.0132
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0131
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0131
6106 Cytochrome P450 2C18 CYP2C18 0.0129
5626 Nucleoside diphosphate kinase B NME2 0.0127
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0124
130 Prostacyclin synthase PTGIS 0.0124
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0124
492 Histamine H1 receptor HRH1 0.0123
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0123
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
6137 Multidrug resistance-associated protein 6 ABCC6 0.0121
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0121
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0121
6207 30S ribosomal protein S14 rpsN 0.012
6209 30S ribosomal protein S19 rpsS 0.012
6712 30S ribosomal protein S19 rpsS 0.012
6726 30S ribosomal protein S19 rpsS 0.012
4094 Gamma-aminobutyric acid type B receptor, subunit 2 GABBR2 0.0119
6030 Cytochrome P450 2B6 CYP2B6 0.0118
2249 Aspartate aminotransferase aspC 0.0112
2671 Aspartate aminotransferase aspC 0.0112
5490 Aspartate aminotransferase Not Available 0.0112
6148 Multidrug resistance-associated protein 7 ABCC10 0.0111
6167 Organic solute transporter subunit beta OSTB 0.0111
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0111
6166 Organic solute transporter subunit alpha OSTA 0.0111
4790 Glycosyltransferase GtfA gtfA 0.011
275 Arachidonate 5-lipoxygenase ALOX5 0.0107
3426 Glutamine synthetase glnA 0.0104
3987 Glutamine synthetase GLUL 0.0104
6033 High affinity interleukin-8 receptor A CXCR1 0.0104
6126 Carbonic anhydrase 7 CA7 0.0103
3639 Thymidine phosphorylase deoA 0.0103
3936 Thymidine phosphorylase TYMP 0.0103
5294 Nucleoside diphosphate kinase A NME1 0.0103
1198 Serum paraoxonase/arylesterase 1 PON1 0.0102
6223 Penicillin-binding protein 1C pbpC 0.0102
527 Prostacyclin receptor PTGIR 0.0102
624 Guanidinoacetate N-methyltransferase GAMT 0.01
2320 Thymidine kinase, cytosolic TK1 0.01
115 Penicillin-binding protein 2 mrdA 0.0099
6069 Penicillin-binding protein 2 mrdA 0.0099
6118 Penicillin-binding protein 2 penA 0.0099
6187 Penicillin-binding protein 2 pbpA 0.0099
6686 Penicillin-binding protein 2 pbp2 0.0099
6939 Penicillin-binding protein 2 mrdA 0.0099
7163 Penicillin-binding protein 2 pbpA 0.0099
672 Prostaglandin F2-alpha receptor PTGFR 0.0099
3947 Xanthine dehydrogenase/oxidase XDH 0.0099
6020 Aldehyde oxidase AOX1 0.0099
1405 Thiopurine S-methyltransferase TPMT 0.0097
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0094
240 Gamma-aminobutyric acid type B receptor, subunit 1 GABBR1 0.0093
1654 Interleukin-1 beta IL1B 0.0092
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0091
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
4604 Liver carboxylesterase 1 CES1 0.0089
6010 Thiamine transporter 1 SLC19A2 0.0089
53 Solute carrier family 12 member 5 SLC12A5 0.0085
663 Solute carrier family 12 member 4 SLC12A4 0.0085
373 Transthyretin TTR 0.0084
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0084
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0084
723 Cytosolic phospholipase A2 PLA2G4A 0.0083
2472 Voltage-gated potassium channel kcsA 0.0083
6366 Voltage-gated potassium channel kcsA 0.0083
65 Matrix metalloproteinase-9 Not Available 0.0082
175 Thiamin pyrophosphokinase 1 TPK1 0.008
310 Solute carrier family 12 member 2 SLC12A2 0.008
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0077
494 Caspase-1 CASP1 0.0075
183 Vascular endothelial growth factor A VEGFA 0.0074
342 P protein [Includes: DNA-directed DNA polymerase P 0.0073
612 P protein [Includes: DNA-directed DNA polymerase P 0.0073
1636 Trace amine-associated receptor 1 TAAR1 0.0073
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0071
1507 Cytochrome c CYCS 0.0071
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0069
3760 Penicillin-binding protein 5 precursor dacA 0.0068
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0067
4217 Telomerase reverse transcriptase TERT 0.0067
3917 Methylenetetrahydrofolate reductase MTHFR 0.0066
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0066
3941 Amine oxidase [flavin-containing] A MAOA 0.0066
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0065
629 Alpha-2B adrenergic receptor ADRA2B 0.0065
3685 Catabolite gene activator crp 0.0065
4655 Adenylate cyclase cyaC 0.0064
4759 Adenylate cyclase cyaB2 0.0064
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0064
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0064
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0063
192 Creatine kinase, ubiquitous mitochondrial CKMT1A 0.0063
456 Creatine kinase, sarcomeric mitochondrial CKMT2 0.0063
92 Creatine kinase B-type CKB 0.0063
414 Sodium- and chloride-dependent creatine transporter 1 SLC6A8 0.0063
5126 Arginase rocF 0.0063
6218 Pannexin-1 PANX1 0.0063
2077 Caspase-3 CASP3 0.0063
474 Acetylcholinesterase ACHE 0.0063
6131 Carbonic anhydrase 14 CA14 0.0062
3811 Cytochrome P450 19A1 CYP19A1 0.0062
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0062
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0062
244 Angiotensin-converting enzyme ACE 0.0061
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.006
509 Thymidine kinase TK 0.006
570 Thymidine kinase TK 0.006
2559 Thymidine kinase TK 0.006
3430 Thymidine kinase tdk 0.006
3518 Thymidine kinase TK 0.006
5301 Thymidine kinase tdk 0.006
5771 Thymidine kinase ORF36 0.006
7009 Thymidine kinase ORF36 0.006
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0059
380 Cytochrome P450 17A1 CYP17A1 0.0059
24 Thymidylate synthase TMP1 0.0059
359 Thymidylate synthase TYMS 0.0059
2626 Thymidylate synthase thyA 0.0059
2729 Thymidylate synthase thyA 0.0059
5352 Thymidylate synthase THYA 0.0059
131 Synaptic vesicular amine transporter SLC18A2 0.0059
713 Sodium-dependent dopamine transporter SLC6A3 0.0059
6085 Fatty acid-binding protein, intestinal FABP2 0.0058
318 Alpha-2A adrenergic receptor ADRA2A 0.0058
6043 Putative G-protein coupled receptor 44 GPR44 0.0058
6122 Carbonic anhydrase 3 CA3 0.0058
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0058
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0057
788 Creatine kinase M-type CKM 0.0057
2981 Phospholipase A2, membrane associated PLA2G2A 0.0057
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0057
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0057
2021 Thrombomodulin THBD 0.0055
3007 Carbonic anhydrase 12 CA12 0.0055
4205 Carbonic anhydrase 9 CA9 0.0055
4760 Mll3241 protein mll3241 0.0055
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
756 Sex hormone-binding globulin SHBG 0.0054
293 Gamma-glutamyl hydrolase GGH 0.0054
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0053
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0053
860 Nicotinamide N-methyltransferase NNMT 0.0051
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0051
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0051
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0051
699 Nicotinic acid receptor 1 GPR109A 0.0051
928 Nicotinic acid receptor 2 GPR109B 0.0051
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.005
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.005
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0049
378 Alpha-2C adrenergic receptor ADRA2C 0.0049
6168 Solute carrier family 22 member 16 SLC22A16 0.0049
1141 Sialidase-1 NEU1 0.0049
64 Neuraminidase NA 0.0049
641 Neuraminidase NA 0.0049
2676 Neuraminidase NA 0.0049
3026 Neuraminidase NA 0.0049
3519 Neuraminidase NA 0.0049
6007 Neuraminidase NA 0.0049
277 Purine nucleoside phosphorylase PNP 0.0049
2870 Purine nucleoside phosphorylase punA 0.0049
2945 Purine nucleoside phosphorylase punA 0.0049
4659 Purine nucleoside phosphorylase TM_1596 0.0049
4825 Purine nucleoside phosphorylase TTHA1435 0.0049
146 Androgen receptor AR 0.0048
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0048
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0048
1650 Heme carrier protein 1 SLC46A1 0.0048
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0048
551 Carnitine O-acetyltransferase CRAT 0.0047
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0046
136 Estrogen receptor ESR1 0.0046
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0044
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0044
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0043
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0043
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0043
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0043
3810 Catechol O-methyltransferase COMT 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
408 Riboflavin kinase RFK 0.0041
5818 Folate receptor alpha FOLR1 0.0041
6042 Prostaglandin reductase 2 PTGR2 0.0041
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.004
489 Monocarboxylate transporter 2 SLC16A7 0.004
6151 Monocarboxylate transporter 10 SLC16A10 0.004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.004
6014 Cytochrome P450 2A13 CYP2A13 0.004
1039 Histone deacetylase 9 HDAC9 0.004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0039
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0039
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0039
828 Phenylalanine-4-hydroxylase PAH 0.0039
3109 Phenylalanine-4-hydroxylase phhA 0.0039
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0039
5482 Sialidase-2 NEU2 0.0039
737 Mineralocorticoid receptor NR3C2 0.0039
1792 Tissue-type plasminogen activator PLAT 0.0038
3939 Amine oxidase [flavin-containing] B MAOB 0.0037
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0037
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0037
2300 Lysozyme E 0.0037
3633 Lysozyme R 0.0037
5597 Lysozyme 17 0.0037
273 Apoptosis regulator Bcl-2 BCL2 0.0037
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0037
5682 Ribonuclease pancreatic RNASE1 0.0036
193 Beta-1 adrenergic receptor ADRB1 0.0036
766 Beta-2 adrenergic receptor ADRB2 0.0035
997 Protein kinase C beta type PRKCB 0.0035
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0035
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0035
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0034
1341 Histamine H3 receptor HRH3 0.0034
594 Thyroxine-binding globulin SERPINA7 0.0034
3932 Glutathione S-transferase A2 GSTA2 0.0034
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0033
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0033
634 Squalene monooxygenase SQLE 0.0033
7196 Squalene monooxygenase ERG1 0.0033
1970 Protein kinase C alpha type PRKCA 0.0033
499 Arginine decarboxylase ADC 0.0033
1898 Cytochrome P450 1B1 CYP1B1 0.0033
164 Histamine H4 receptor HRH4 0.0032
2408 Tyrosine-protein kinase SYK SYK 0.0032
500 Monocarboxylate transporter 4 SLC16A3 0.0032
556 Alpha-1A adrenergic receptor ADRA1A 0.0032
3923 Cholinesterase BCHE 0.0031
758 Thyroid hormone receptor alpha THRA 0.0031
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0031
789 Alpha-1D adrenergic receptor ADRA1D 0.0031
1313 Lactoylglutathione lyase GLO1 0.0031
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0031
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0031
577 Argininosuccinate lyase ASL 0.0031
834 Arginase-2, mitochondrial ARG2 0.0031
150 Cationic amino acid transporter 3 SLC7A3 0.003
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.003
58 Cationic amino acid transporter 4 SLC7A4 0.003
824 Sodium-dependent serotonin transporter SLC6A4 0.003
654 Flavin reductase BLVRB 0.0029
751 Potassium channel subfamily K member 6 KCNK6 0.0029
952 Dipeptidyl peptidase 4 DPP4 0.0029
3587 Gastrotropin FABP6 0.0028
632 Alpha-1B adrenergic receptor ADRA1B 0.0028
740 Argininosuccinate synthase ASS1 0.0028
865 Argininosuccinate synthase ASS1 0.0028
2680 Argininosuccinate synthase argG 0.0028
3194 Argininosuccinate synthase argG 0.0028
346 Thyroid hormone receptor beta-1 THRB 0.0028
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0028
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0028
1025 Aquaporin-1 AQP1 0.0027
172 Potassium channel subfamily K member 1 KCNK1 0.0027
6171 Solute carrier family 28 member 3 SLC28A3 0.0026
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0026
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0026
4203 Histamine N-methyltransferase HNMT 0.0026
4773 Deoxycytidine kinase DCK 0.0026
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0026
976 Platelet glycoprotein IX GP9 0.0025
707 72 kDa type IV collagenase MMP2 0.0025
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0024
2236 Casein kinase II subunit alpha CSNK2A1 0.0024
6031 Cytochrome P450 3A43 CYP3A43 0.0024
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0022
365 Dihydrofolate reductase DHFR 0.0022
2381 Dihydrofolate reductase DFR1 0.0022
2833 Dihydrofolate reductase Not Available 0.0022
2931 Dihydrofolate reductase folA 0.0022
3544 Dihydrofolate reductase folA 0.0022
3682 Dihydrofolate reductase folA 0.0022
6642 Dihydrofolate reductase folA 0.0022
6756 Dihydrofolate reductase dfrA 0.0022
3014 Ribonuclease UK114 HRSP12 0.0022
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0022
3617 Non-heme chloroperoxidase cpo 0.0022
5426 Non-heme chloroperoxidase cpo 0.0022
5428 Replication protein repA 0.0022
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0022
3018 HTH-type transcriptional regulator malT malT 0.0022
3830 Calreticulin CALR 0.0022
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0022
1196 Complement decay-accelerating factor CD55 0.0021
718 Folate receptor gamma FOLR3 0.0021
299 Folate receptor beta FOLR2 0.0021
804 Mitochondrial folate transporter/carrier SLC25A32 0.0021
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0021
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.002
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.002
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.002
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.002
769 High-affinity choline transporter 1 SLC5A7 0.002
3933 Choline/ethanolaminephosphotransferase CEPT1 0.002
861 Choline kinase alpha CHKA 0.002
844 Epidermal growth factor receptor EGFR 0.002
700 Choline dehydrogenase, mitochondrial CHDH 0.002
3927 Choline transporter-like protein 3 SLC44A3 0.002
1686 Choline transporter-like protein 1 SLC44A1 0.002
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.002
3926 Choline transporter-like protein 2 SLC44A2 0.002
3925 Choline transporter-like protein 4 SLC44A4 0.002
576 Choline O-acetyltransferase CHAT 0.002
3922 Phospholipase D2 PLD2 0.002
3924 Phospholipase D1 PLD1 0.002
6034 Hydroxyindole O-methyltransferase ASMT 0.002
6035 Nuclear receptor ROR-beta RORB 0.002
6036 Eosinophil peroxidase EPX 0.002
1714 Mitogen-activated protein kinase 3 MAPK3 0.0019
7 Nitric oxide synthase, inducible NOS2 0.0019
291 Nitric-oxide synthase, endothelial NOS3 0.0019
2958 Probable tautomerase ydcE pptA 0.0019
2573 Cocaine esterase cocE 0.0019
7263 Cocaine esterase Not Available 0.0019
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0019
2808 Chloramphenicol acetyltransferase 3 cat3 0.0019
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0019
3115 Ras-related protein Rab-9 RAB9A 0.0019
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0018
1517 Beta-3 adrenergic receptor ADRB3 0.0018
153 Dopamine beta-hydroxylase DBH 0.0018
869 Estrogen receptor beta ESR2 0.0017
765 Indoleamine 2,3-dioxygenase IDO1 0.0017
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
2810 Dr hemagglutinin structural subunit draA 0.0017
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0017
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0017
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0016
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0016
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0016
571 Melatonin receptor type 1A MTNR1A 0.0016
362 Melatonin receptor type 1B MTNR1B 0.0016
459 Retinoic acid receptor RXR-alpha RXRA 0.0016
33 Cystine/glutamate transporter SLC7A11 0.0016
1360 Sphingomyelin phosphodiesterase SMPD1 0.0016
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0015
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0015
2693 Heat-labile enterotoxin B chain eltB 0.0014
199 Monocarboxylate transporter 8 SLC16A2 0.0014
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0014
6645 D-amino-acid oxidase DAO 0.0014
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0014
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0014
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0014
822 Aldose reductase AKR1B1 0.0014
163 D(1B) dopamine receptor DRD5 0.0013
4010 Mitochondrial dicarboxylate carrier SLC25A10 0.0013
1410 Oxidoreductase HSD17B6 0.0013
4725 Oxidoreductase Not Available 0.0013
5124 Oxidoreductase Not Available 0.0013
4007 Succinate receptor 1 SUCNR1 0.0013
4008 Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial OXCT2 0.0013
4002 Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial SUCLG1 0.0013
673 Solute carrier family 13 member 3 SLC13A3 0.0013
432 D(4) dopamine receptor DRD4 0.0013
391 Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial SUCLG2 0.0013
4009 Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial SUCLA2 0.0013
498 Solute carrier family 13 member 2 SLC13A2 0.0013
25 Solute carrier family 13 member 1 SLC13A1 0.0013
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0013
638 D(3) dopamine receptor DRD3 0.0012
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0012
702 UMP-CMP kinase CMPK1 0.0012
4003 Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial OXCT1 0.0012
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0012
6432 Transporter snf 0.0011
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.0011
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0011
23 D(1A) dopamine receptor DRD1 0.0011
2391 Ferrochelatase hemH 0.0011
6502 Ferrochelatase DKFZp686P18130 0.0011
1591 Ferrochelatase, mitochondrial FECH 0.0011
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0011
3940 Gamma-butyrobetaine dioxygenase BBOX1 0.0011
97 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 0.0011
3938 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 PLOD3 0.0011
3964 Trimethyllysine dioxygenase, mitochondrial TMLHE 0.0011
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0011
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0011
4006 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC 0.0011
4001 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 0.0011
465 Calmodulin CALM1 0.0011
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0011
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.001
1192 Sulfotransferase 1A1 SULT1A1 0.001
70 Type-1 angiotensin II receptor AGTR1 0.001
831 D(2) dopamine receptor DRD2 0.001
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.001
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.001
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.001
3999 Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial SDHD 0.001
1275 Estrogen sulfotransferase SULT1E1 0.001
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.001
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.001
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.001
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.001
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.001
6493 Cytochrome c oxidase subunit 6C COX6C 0.001
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.001
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.001
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.001
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.001
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.001
6559 Cytochrome c oxidase subunit 2 ctaC 0.001
6669 Cytochrome c oxidase subunit 2 ctaC 0.001
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.001
371 Cytochrome c oxidase subunit 1 MT-CO1 0.001
6558 Cytochrome c oxidase subunit 1 ctaD 0.001
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.001
1050 Bile salt sulfotransferase SULT2A1 0.001
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0009
6102 Arylamine N-acetyltransferase 2 NAT2 0.0009
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0009
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0009
2540 Choloylglycine hydrolase cbh 0.0009
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0009
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0009
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0008
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0008
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0008
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0008
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0008
6501 Fatty acid-binding protein, liver FABP1 0.0008
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0008
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0008
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0008
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0008
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0008
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0008
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0008
3809 Estrogen-related receptor gamma ESRRG 0.0007
6500 Phospholipase A2 PLA2G1B 0.0007
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0007
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0007
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0007
502 5-hydroxytryptamine 2A receptor HTR2A 0.0007
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0007
517 Alcohol dehydrogenase 1C ADH1C 0.0006
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