DT-Web

DB02267 - Argininosuccinate


Identification
Name Argininosuccinate
Accession Number DB02267 (EXPT00565)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 290.2731
Groups experimental
Monoisotopic Weight 290.122634328
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Argininosuccinate lyase
Name Argininosuccinate lyase
Gene Name ASL
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.7177
Argininosuccinate synthase
Name Argininosuccinate synthase
Gene Name argG
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.0312

Predictions


Id Partner name Gene Name Score
834 Arginase-2, mitochondrial ARG2 0.0388
150 Cationic amino acid transporter 3 SLC7A3 0.0359
499 Arginine decarboxylase ADC 0.0359
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.0359
58 Cationic amino acid transporter 4 SLC7A4 0.0359
740 Argininosuccinate synthase ASS1 0.0312
865 Argininosuccinate synthase ASS1 0.0312
3194 Argininosuccinate synthase argG 0.0312
7 Nitric oxide synthase, inducible NOS2 0.0242
291 Nitric-oxide synthase, endothelial NOS3 0.0241
6151 Monocarboxylate transporter 10 SLC16A10 0.0215
3794 Osmolarity sensor protein envZ envZ 0.0213
5641 Rod shape-determining protein MreB TM_0588 0.0213
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0213
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0213
5644 Sensor protein phoQ phoQ 0.0213
5645 DNA topoisomerase 4 subunit B parE 0.0213
6227 DNA topoisomerase 4 subunit B parE 0.0213
5643 General secretion pathway protein E epsE 0.0213
5642 Chaperone clpB clpB 0.0213
4178 DNA repair protein RAD51 homolog 1 RAD51 0.0213
5649 Potassium-transporting ATPase B chain kdpB 0.0213
833 Organic cation/carnitine transporter 1 SLC22A4 0.0203
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0185
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0185
2867 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ispE 0.0185
2282 Protein recA recA 0.0185
2315 Protein recA recA 0.0185
2332 Protein recA recA 0.0185
5263 Protein recA recA 0.0185
4751 Mitogen-activated protein kinase 12 MAPK12 0.0185
5646 Galactokinase GALK1 0.0185
5265 FtsH ftsH 0.0185
6433 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 PFKFB4 0.0185
5302 TrwB trwB 0.0185
2397 Dihydroxyacetone kinase dhaK 0.0185
2852 DNA mismatch repair protein mutL mutL 0.0185
118 Organic cation/carnitine transporter 2 SLC22A5 0.0172
5443 UPF0189 protein ymdB ymdB 0.0171
5446 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase HI_1679 0.0171
5440 UPF0067 protein yebR yebR 0.0171
2720 Copper-containing nitrite reductase nirK 0.0171
4705 Manganese catalase Not Available 0.0171
5449 Hypothetical gliding protein mglB 0.0171
332 Beta-lactamase blaZ 0.0171
2478 Beta-lactamase ampC 0.0171
2613 Beta-lactamase ampC 0.0171
2635 Beta-lactamase ampC 0.0171
2700 Beta-lactamase penP 0.0171
5445 Beta-lactamase blaB 0.0171
6019 Beta-lactamase SHV-7 0.0171
6701 Beta-lactamase cphA 0.0171
5448 Ribonuclease Z rnz 0.0171
3781 Thiol:disulfide interchange protein dsbC precursor dsbC 0.0171
5439 33 kDa chaperonin hslO 0.0171
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0171
5454 Internalin-A inlA 0.0171
2299 UDP-N-acetylmuramate--L-alanine ligase murC 0.0171
5312 Kinesin-like protein KIF1A KIF1A 0.0171
5447 Lethal(3)malignant brain tumor-like protein L3MBTL1 0.0171
3231 Death-associated protein kinase 1 DAPK1 0.0171
2892 Acetylglutamate kinase argB 0.0161
3550 Acetylglutamate kinase argB 0.0161
2371 Pantothenate kinase coaA 0.0161
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0161
825 Arsenical pump-driving ATPase ASNA1 0.0161
3435 Arsenical pump-driving ATPase arsA 0.0161
1881 Hexokinase-1 HK1 0.0161
2615 Chemotaxis protein cheA cheA 0.0161
4498 Ornithine cyclodeaminase PP3533 0.016
3356 Diaminopimelate decarboxylase lysA 0.0154
2727 S-adenosylmethionine synthetase metK 0.0154
4771 Dissimilatory copper-containing nitrite reductase nir 0.0153
3274 Hydroxylamine reductase hcp 0.0153
4804 Hydroxylamine reductase hcp 0.0153
5450 Prolyl endopeptidase Pep pep 0.0151
2714 Chorismate mutase aroH 0.0151
4611 Chorismate mutase aroG 0.0151
887 DNA gyrase subunit B gyrB 0.0149
4150 DNA gyrase subunit B gyrB 0.0149
6225 DNA gyrase subunit B gyrB 0.0149
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0149
936 Ephrin type-A receptor 2 EPHA2 0.0148
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0147
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0144
3399 Limonene-1,2-epoxide hydrolase limA 0.0139
958 Insulin-like growth factor 1 receptor IGF1R 0.0137
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.0137
3462 Tyrosine-protein kinase transforming protein Abl ABL 0.0136
2251 Thymidylate kinase tmk 0.0132
2254 Thymidylate kinase DTYMK 0.0132
3522 Thymidylate kinase tmk 0.0132
5180 L(+)-mandelate dehydrogenase mdlB 0.0132
3500 Putative family 31 glucosidase yicI yicI 0.0129
597 Dihydropteridine reductase QDPR 0.0129
4608 Putative cytochrome P450 SCO1207 0.0128
4963 Putative cytochrome P450 SCO2884 0.0128
6254 Putative cytochrome P450 SCO6998 0.0128
3822 Actin, alpha skeletal muscle ACTA1 0.0125
3480 Mannan endo-1,4-beta-mannosidase manA 0.0125
1615 Chymase CMA1 0.0123
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0123
207 Glutathione synthetase GSS 0.0121
5269 Glutathione synthetase gshB 0.0121
1836 Mitogen-activated protein kinase 10 MAPK10 0.0121
2597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] glmS 0.012
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.012
4192 DNA topoisomerase 2-beta TOP2B 0.0117
365 Dihydrofolate reductase DHFR 0.0115
2381 Dihydrofolate reductase DFR1 0.0115
2833 Dihydrofolate reductase Not Available 0.0115
2931 Dihydrofolate reductase folA 0.0115
3544 Dihydrofolate reductase folA 0.0115
3682 Dihydrofolate reductase folA 0.0115
6642 Dihydrofolate reductase folA 0.0115
6756 Dihydrofolate reductase dfrA 0.0115
1721 Glycogen synthase kinase-3 beta GSK3B 0.0114
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0114
287 Beta-1,4-galactosyltransferase 1 B4GALT1 0.0113
2236 Casein kinase II subunit alpha CSNK2A1 0.0113
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0092
904 Glutathione S-transferase P GSTP1 0.0083
474 Acetylcholinesterase ACHE 0.0069
3923 Cholinesterase BCHE 0.0058
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