DT-Web

DB00438 - Ceftazidime


Identification
Name Ceftazidime
Accession Number DB00438 (APRD00857)
Type small molecule
Description Semisynthetic, broad-spectrum antibacterial derived from cephaloridine and used especially for Pseudomonas and other gram-negative infections in debilitated patients. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 546.576
Groups approved
Monoisotopic Weight 546.099138468
Pharmacology
Indication For the treatment of patients with infections caused by susceptible strains of organisms in the following diseases: lower respiratory tract infections,skin and skin structure infections, urinary tract infections, bacterial septicemia, bone and joint infections, gynecologic infections, intra abdominal infections (including peritonitis), and central nervous system infections (including meningitis).
Mechanism of action The bactericidal activity of ceftazidime results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins (PBPs).
Absorption The absorption of ceftazidime is directly proportional to the size of the dose.
Protein binding < 10%
Biotransformation Not Available
Route of elimination The elimination of ceftazidime by the kidneys resulted in high therapeutic concentrations in the urine.
Toxicity Ceftazidime overdosage has occurred in patients with renal failure. Reactions have included seizure activity, encephalopathy, asterixis, neuromuscular excitability, and coma.
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions
Drug Mechanism of interaction
Amikacin Increased risk of nephrotoxicity
Gentamicin Increased risk of nephrotoxicity
Kanamycin Increased risk of nephrotoxicity
Neomycin Increased risk of nephrotoxicity
Netilmicin Increased risk of nephrotoxicity
Streptomycin Increased risk of nephrotoxicity
Tobramycin Increased risk of nephrotoxicity
Food Interactions Not Available

Targets


Peptidoglycan synthetase ftsI
Name Peptidoglycan synthetase ftsI
Gene Name ftsI
Pharmacological action yes
Actions inhibitor
References
  • Hayes MV, Orr DC: Mode of action of ceftazidime: affinity for the penicillin-binding proteins of Escherichia coli K12, Pseudomonas aeruginosa and Staphylococcus aureus. J Antimicrob Chemother. 1983 Aug;12(2):119-26. - Pubmed
DTHybrid score 0.082
Penicillin-binding protein 3
Name Penicillin-binding protein 3
Gene Name pbp3
Pharmacological action yes
Actions inhibitor
References
  • Hayes MV, Orr DC: Mode of action of ceftazidime: affinity for the penicillin-binding proteins of Escherichia coli K12, Pseudomonas aeruginosa and Staphylococcus aureus. J Antimicrob Chemother. 1983 Aug;12(2):119-26. - Pubmed
DTHybrid score 0.1579
Penicillin-binding protein 1A
Name Penicillin-binding protein 1A
Gene Name mrcA
Pharmacological action yes
Actions inhibitor
References
  • Hayes MV, Orr DC: Mode of action of ceftazidime: affinity for the penicillin-binding proteins of Escherichia coli K12, Pseudomonas aeruginosa and Staphylococcus aureus. J Antimicrob Chemother. 1983 Aug;12(2):119-26. - Pubmed
DTHybrid score 0.8364
Penicillin-binding protein 1A
Name Penicillin-binding protein 1A
Gene Name pbpA
Pharmacological action yes
Actions inhibitor
References
  • Hayes MV, Orr DC: Mode of action of ceftazidime: affinity for the penicillin-binding proteins of Escherichia coli K12, Pseudomonas aeruginosa and Staphylococcus aureus. J Antimicrob Chemother. 1983 Aug;12(2):119-26. - Pubmed
DTHybrid score 0.8364
Penicillin-binding protein 1B
Name Penicillin-binding protein 1B
Gene Name mrcB
Pharmacological action yes
Actions inhibitor
References
  • Hayes MV, Orr DC: Mode of action of ceftazidime: affinity for the penicillin-binding proteins of Escherichia coli K12, Pseudomonas aeruginosa and Staphylococcus aureus. J Antimicrob Chemother. 1983 Aug;12(2):119-26. - Pubmed
DTHybrid score 0.8148
Penicillin-binding protein 1B
Name Penicillin-binding protein 1B
Gene Name ponB
Pharmacological action yes
Actions inhibitor
References
  • Hayes MV, Orr DC: Mode of action of ceftazidime: affinity for the penicillin-binding proteins of Escherichia coli K12, Pseudomonas aeruginosa and Staphylococcus aureus. J Antimicrob Chemother. 1983 Aug;12(2):119-26. - Pubmed
DTHybrid score 0.8148
Penicillin-binding protein 2
Name Penicillin-binding protein 2
Gene Name pbpA
Pharmacological action yes
Actions inhibitor
References
  • Hayes MV, Orr DC: Mode of action of ceftazidime: affinity for the penicillin-binding proteins of Escherichia coli K12, Pseudomonas aeruginosa and Staphylococcus aureus. J Antimicrob Chemother. 1983 Aug;12(2):119-26. - Pubmed
DTHybrid score 0.1082
Penicillin-binding protein 2
Name Penicillin-binding protein 2
Gene Name mrdA
Pharmacological action yes
Actions inhibitor
References
  • Hayes MV, Orr DC: Mode of action of ceftazidime: affinity for the penicillin-binding proteins of Escherichia coli K12, Pseudomonas aeruginosa and Staphylococcus aureus. J Antimicrob Chemother. 1983 Aug;12(2):119-26. - Pubmed
DTHybrid score 0.1082
D-alanyl-D-alanine endopeptidase
Name D-alanyl-D-alanine endopeptidase
Gene Name pbpG
Pharmacological action no
Actions inhibitor
References
  • Hayes MV, Orr DC: Mode of action of ceftazidime: affinity for the penicillin-binding proteins of Escherichia coli K12, Pseudomonas aeruginosa and Staphylococcus aureus. J Antimicrob Chemother. 1983 Aug;12(2):119-26. - Pubmed
DTHybrid score Not Available

Transporters


Organic cation/carnitine transporter 2
Name Organic cation/carnitine transporter 2
Gene Name SLC22A5
Actions inhibitor
References
  • Ganapathy ME, Huang W, Rajan DP, Carter AL, Sugawara M, Iseki K, Leibach FH, Ganapathy V: beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. J Biol Chem. 2000 Jan 21;275(3):1699-707. - Pubmed
DTHybrid score 0.41
Oligopeptide transporter, small intestine isoform
Name Oligopeptide transporter, small intestine isoform
Gene Name SLC15A1
Actions inhibitor
References
  • Ganapathy ME, Huang W, Rajan DP, Carter AL, Sugawara M, Iseki K, Leibach FH, Ganapathy V: beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. J Biol Chem. 2000 Jan 21;275(3):1699-707. - Pubmed
  • Luckner P, Brandsch M: Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. Eur J Pharm Biopharm. 2005 Jan;59(1):17-24. - Pubmed
DTHybrid score 0.8179
Oligopeptide transporter, kidney isoform
Name Oligopeptide transporter, kidney isoform
Gene Name SLC15A2
Actions inhibitor
References
  • Ganapathy ME, Huang W, Rajan DP, Carter AL, Sugawara M, Iseki K, Leibach FH, Ganapathy V: beta-lactam antibiotics as substrates for OCTN2, an organic cation/carnitine transporter. J Biol Chem. 2000 Jan 21;275(3):1699-707. - Pubmed
  • Luckner P, Brandsch M: Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1. Eur J Pharm Biopharm. 2005 Jan;59(1):17-24. - Pubmed
DTHybrid score 0.7778
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions inhibitor
References
  • Jariyawat S, Sekine T, Takeda M, Apiwattanakul N, Kanai Y, Sophasan S, Endou H: The interaction and transport of beta-lactam antibiotics with the cloned rat renal organic anion transporter 1. J Pharmacol Exp Ther. 1999 Aug;290(2):672-7. - Pubmed
DTHybrid score 0.4788

Predictions


Id Partner name Gene Name Score
5805 Penicillin-binding protein 1A ponA 0.8364
6185 Penicillin-binding protein 1A mrcA 0.8364
6822 Penicillin-binding protein 1b pbp1b 0.8148
6844 Penicillin-binding protein 1b pbp1b 0.8148
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.3143
819 Penicillin-binding protein 4 dacB 0.2878
633 Penicillin-binding proteins 1A/1B pbpA 0.2543
587 Serum albumin ALB 0.2194
6142 Solute carrier family 22 member 8 SLC22A8 0.2152
244 Angiotensin-converting enzyme ACE 0.1783
6067 Penicillin binding protein 2a mecA 0.1782
3760 Penicillin-binding protein 5 precursor dacA 0.1614
867 Penicillin-binding protein 3 pbpC 0.1579
6119 Penicillin-binding protein 3 pbp3 0.1579
7157 Penicillin-binding protein 3 LMHCC_2184 0.1579
7162 Penicillin-binding protein 3 pbpB 0.1579
7172 Penicillin-binding protein 3 pbp3 0.1579
1024 Solute carrier family 22 member 11 SLC22A11 0.1462
115 Penicillin-binding protein 2 mrdA 0.1082
6118 Penicillin-binding protein 2 penA 0.1082
6187 Penicillin-binding protein 2 pbpA 0.1082
6686 Penicillin-binding protein 2 pbp2 0.1082
6939 Penicillin-binding protein 2 mrdA 0.1082
6113 MecA PBP2' (penicillin binding protein 2') mecA 0.1071
6143 Solute carrier family 22 member 7 SLC22A7 0.0929
332 Beta-lactamase blaZ 0.0841
2478 Beta-lactamase ampC 0.0841
2613 Beta-lactamase ampC 0.0841
2635 Beta-lactamase ampC 0.0841
2700 Beta-lactamase penP 0.0841
5445 Beta-lactamase blaB 0.0841
6019 Beta-lactamase SHV-7 0.0841
6701 Beta-lactamase cphA 0.0841
1 Peptidoglycan synthetase ftsI ftsI 0.082
4512 Cytochrome P450 3A4 CYP3A4 0.0743
1198 Serum paraoxonase/arylesterase 1 PON1 0.0613
6223 Penicillin-binding protein 1C pbpC 0.0613
1588 Multidrug resistance protein 1 ABCB1 0.0578
833 Organic cation/carnitine transporter 1 SLC22A4 0.0533
4119 Cytochrome P450 2D6 CYP2D6 0.0506
2164 Multidrug resistance-associated protein 4 ABCC4 0.0451
4757 Cytochrome P450 2C9 CYP2C9 0.039
6145 Solute carrier family 22 member 1 SLC22A1 0.0387
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0384
4200 Cytochrome P450 1A2 CYP1A2 0.0377
738 Monocarboxylate transporter 1 SLC16A1 0.0365
1405 Thiopurine S-methyltransferase TPMT 0.036
6016 Cytochrome P450 2C19 CYP2C19 0.0358
20 Prostaglandin G/H synthase 1 PTGS1 0.0358
3195 Beta-lactamase Toho-1 bla 0.0357
1385 Angiotensin-converting enzyme 2 ACE2 0.035
6144 Solute carrier family 22 member 2 SLC22A2 0.0339
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0334
1757 Myeloperoxidase MPO 0.0332
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0325
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0325
404 DNA gyrase subunit A gyrA 0.0314
6224 DNA gyrase subunit A gyrA 0.0314
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0267
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0263
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0252
290 Prostaglandin G/H synthase 2 PTGS2 0.025
6147 Solute carrier family 22 member 3 SLC22A3 0.0249
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0246
234 Plasminogen PLG 0.0246
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0242
477 DNA topoisomerase 4 subunit A parC 0.0242
886 DNA topoisomerase 4 subunit A parC 0.0242
6226 DNA topoisomerase 4 subunit A parC 0.0242
3923 Cholinesterase BCHE 0.0234
56 Delta-aminolevulinic acid dehydratase ALAD 0.023
2356 Delta-aminolevulinic acid dehydratase hemB 0.023
3613 Delta-aminolevulinic acid dehydratase hemB 0.023
3674 Delta-aminolevulinic acid dehydratase hemB 0.023
862 Multidrug resistance-associated protein 1 ABCC1 0.023
4924 Cytochrome P450 2C8 CYP2C8 0.0215
3917 Methylenetetrahydrofolate reductase MTHFR 0.021
338 DNA polymerase UL30 0.0203
379 DNA polymerase UL54 0.0203
697 DNA polymerase ORF28 0.0203
2482 DNA polymerase 43 0.0203
4104 DNA polymerase BALF5 0.0203
2544 Bacterial leucyl aminopeptidase Not Available 0.0198
4604 Liver carboxylesterase 1 CES1 0.0197
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0174
817 DNA topoisomerase 2-alpha TOP2A 0.0174
6106 Cytochrome P450 2C18 CYP2C18 0.0153
159 Penicillin-binding protein 2B penA 0.0151
6121 Penicillin-binding protein 2B penA 0.0151
4118 Cytochrome P450 3A5 CYP3A5 0.0149
3060 Leukotriene A-4 hydrolase LTA4H 0.0149
4252 Penicillin-binding protein 5 dacA 0.0146
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
592 Carbonic anhydrase 4 CA4 0.0141
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0139
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0135
357 Carbonic anhydrase 2 CA2 0.0135
295 Carbonic anhydrase 1 CA1 0.0133
6024 Cytochrome P450 1A1 CYP1A1 0.013
6107 Cytochrome P450 3A7 CYP3A7 0.0129
318 Alpha-2A adrenergic receptor ADRA2A 0.0129
509 Thymidine kinase TK 0.0126
570 Thymidine kinase TK 0.0126
2559 Thymidine kinase TK 0.0126
3430 Thymidine kinase tdk 0.0126
3518 Thymidine kinase TK 0.0126
5301 Thymidine kinase tdk 0.0126
5771 Thymidine kinase ORF36 0.0126
7009 Thymidine kinase ORF36 0.0126
492 Histamine H1 receptor HRH1 0.0123
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0118
5718 Cytochrome P450 2A6 CYP2A6 0.0118
776 Bile salt export pump ABCB11 0.0117
3810 Catechol O-methyltransferase COMT 0.0112
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0111
3426 Glutamine synthetase glnA 0.011
3987 Glutamine synthetase GLUL 0.011
4790 Glycosyltransferase GtfA gtfA 0.011
3639 Thymidine phosphorylase deoA 0.0103
3936 Thymidine phosphorylase TYMP 0.0103
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0098
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0095
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0092
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0092
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
6010 Thiamine transporter 1 SLC19A2 0.0089
6013 Cytochrome P450 2E1 CYP2E1 0.0087
558 Solute carrier family 12 member 1 SLC12A1 0.0086
632 Alpha-1B adrenergic receptor ADRA1B 0.0084
723 Cytosolic phospholipase A2 PLA2G4A 0.0083
6030 Cytochrome P450 2B6 CYP2B6 0.0082
2016 Dipeptidase 1 DPEP1 0.0082
6126 Carbonic anhydrase 7 CA7 0.0082
556 Alpha-1A adrenergic receptor ADRA1A 0.0081
175 Thiamin pyrophosphokinase 1 TPK1 0.008
624 Guanidinoacetate N-methyltransferase GAMT 0.0078
6137 Multidrug resistance-associated protein 6 ABCC6 0.0077
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0075
707 72 kDa type IV collagenase MMP2 0.0073
1636 Trace amine-associated receptor 1 TAAR1 0.0073
22 30S ribosomal protein S4 rpsD 0.0072
6714 30S ribosomal protein S4 rpsD 0.0072
65 Matrix metalloproteinase-9 Not Available 0.0072
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0071
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0071
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0069
140 30S ribosomal protein S9 rpsI 0.0068
6719 30S ribosomal protein S9 rpsI 0.0068
6725 30S ribosomal protein S9 rpsI 0.0068
1141 Sialidase-1 NEU1 0.0068
64 Neuraminidase NA 0.0068
641 Neuraminidase NA 0.0068
2676 Neuraminidase NA 0.0068
3026 Neuraminidase NA 0.0068
3519 Neuraminidase NA 0.0068
6007 Neuraminidase NA 0.0068
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0068
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0067
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0066
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0065
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0065
629 Alpha-2B adrenergic receptor ADRA2B 0.0065
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0064
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0064
192 Creatine kinase, ubiquitous mitochondrial CKMT1A 0.0063
456 Creatine kinase, sarcomeric mitochondrial CKMT2 0.0063
92 Creatine kinase B-type CKB 0.0063
414 Sodium- and chloride-dependent creatine transporter 1 SLC6A8 0.0063
474 Acetylcholinesterase ACHE 0.0063
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0062
6136 Multidrug resistance-associated protein 5 ABCC5 0.0061
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.006
5626 Nucleoside diphosphate kinase B NME2 0.006
2320 Thymidine kinase, cytosolic TK1 0.0059
380 Cytochrome P450 17A1 CYP17A1 0.0059
131 Synaptic vesicular amine transporter SLC18A2 0.0059
3941 Amine oxidase [flavin-containing] A MAOA 0.0059
713 Sodium-dependent dopamine transporter SLC6A3 0.0059
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0059
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0057
788 Creatine kinase M-type CKM 0.0057
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0056
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0056
466 Solute carrier family 12 member 3 SLC12A3 0.0055
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0054
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0054
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0053
5482 Sialidase-2 NEU2 0.0052
860 Nicotinamide N-methyltransferase NNMT 0.0051
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0051
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0051
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0051
699 Nicotinic acid receptor 1 GPR109A 0.0051
928 Nicotinic acid receptor 2 GPR109B 0.0051
438 Taste receptor type 1 member 2 TAS1R2 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
6141 Sodium/bile acid cotransporter SLC10A1 0.005
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.005
378 Alpha-2C adrenergic receptor ADRA2C 0.0049
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0049
277 Purine nucleoside phosphorylase PNP 0.0049
2870 Purine nucleoside phosphorylase punA 0.0049
2945 Purine nucleoside phosphorylase punA 0.0049
4659 Purine nucleoside phosphorylase TM_1596 0.0049
4825 Purine nucleoside phosphorylase TTHA1435 0.0049
5294 Nucleoside diphosphate kinase A NME1 0.0048
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0048
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0048
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0046
2472 Voltage-gated potassium channel kcsA 0.0046
6366 Voltage-gated potassium channel kcsA 0.0046
373 Transthyretin TTR 0.0046
6149 Solute carrier family 22 member 10 SLC22A10 0.0046
3686 Acyl-CoA thioesterase I precursor tesA 0.0045
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0045
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0044
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0044
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
6148 Multidrug resistance-associated protein 7 ABCC10 0.0042
887 DNA gyrase subunit B gyrB 0.0041
4150 DNA gyrase subunit B gyrB 0.0041
6225 DNA gyrase subunit B gyrB 0.0041
408 Riboflavin kinase RFK 0.0041
24 Thymidylate synthase TMP1 0.0041
359 Thymidylate synthase TYMS 0.0041
2626 Thymidylate synthase thyA 0.0041
2729 Thymidylate synthase thyA 0.0041
5352 Thymidylate synthase THYA 0.0041
6151 Monocarboxylate transporter 10 SLC16A10 0.004
124 Histamine H2 receptor HRH2 0.004
275 Arachidonate 5-lipoxygenase ALOX5 0.004
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.004
828 Phenylalanine-4-hydroxylase PAH 0.0039
3109 Phenylalanine-4-hydroxylase phhA 0.0039
737 Mineralocorticoid receptor NR3C2 0.0039
163 D(1B) dopamine receptor DRD5 0.0038
3939 Amine oxidase [flavin-containing] B MAOB 0.0037
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0037
5353 Glutamate decarboxylase alpha gadA 0.0037
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0037
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0037
193 Beta-1 adrenergic receptor ADRB1 0.0036
5126 Arginase rocF 0.0036
432 D(4) dopamine receptor DRD4 0.0036
766 Beta-2 adrenergic receptor ADRB2 0.0035
6131 Carbonic anhydrase 14 CA14 0.0035
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0035
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0035
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0035
638 D(3) dopamine receptor DRD3 0.0034
1341 Histamine H3 receptor HRH3 0.0034
3932 Glutathione S-transferase A2 GSTA2 0.0034
6122 Carbonic anhydrase 3 CA3 0.0033
3007 Carbonic anhydrase 12 CA12 0.0033
499 Arginine decarboxylase ADC 0.0033
4205 Carbonic anhydrase 9 CA9 0.0033
164 Histamine H4 receptor HRH4 0.0032
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0032
109 Mitochondrial carnitine/acylcarnitine carrier protein CACL SLC25A29 0.0032
636 Mitochondrial carnitine/acylcarnitine carrier protein SLC25A20 0.0032
500 Monocarboxylate transporter 4 SLC16A3 0.0032
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0031
789 Alpha-1D adrenergic receptor ADRA1D 0.0031
23 D(1A) dopamine receptor DRD1 0.0031
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0031
342 P protein [Includes: DNA-directed DNA polymerase P 0.0031
612 P protein [Includes: DNA-directed DNA polymerase P 0.0031
577 Argininosuccinate lyase ASL 0.0031
834 Arginase-2, mitochondrial ARG2 0.0031
150 Cationic amino acid transporter 3 SLC7A3 0.003
235 High-affinity cationic amino acid transporter 1 SLC7A1 0.003
58 Cationic amino acid transporter 4 SLC7A4 0.003
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.003
824 Sodium-dependent serotonin transporter SLC6A4 0.003
6014 Cytochrome P450 2A13 CYP2A13 0.0029
654 Flavin reductase BLVRB 0.0029
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0029
831 D(2) dopamine receptor DRD2 0.0029
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0029
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0028
6043 Putative G-protein coupled receptor 44 GPR44 0.0028
1867 Major prion protein PRNP 0.0028
740 Argininosuccinate synthase ASS1 0.0028
865 Argininosuccinate synthase ASS1 0.0028
2680 Argininosuccinate synthase argG 0.0028
3194 Argininosuccinate synthase argG 0.0028
6168 Solute carrier family 22 member 16 SLC22A16 0.0028
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0028
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0027
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0027
1025 Aquaporin-1 AQP1 0.0027
412 Peroxisomal carnitine O-octanoyltransferase CROT 0.0027
6218 Pannexin-1 PANX1 0.0027
3685 Catabolite gene activator crp 0.0027
1039 Histone deacetylase 9 HDAC9 0.0027
551 Carnitine O-acetyltransferase CRAT 0.0027
4655 Adenylate cyclase cyaC 0.0027
4759 Adenylate cyclase cyaB2 0.0027
4203 Histamine N-methyltransferase HNMT 0.0026
293 Gamma-glutamyl hydrolase GGH 0.0026
4773 Deoxycytidine kinase DCK 0.0026
976 Platelet glycoprotein IX GP9 0.0025
130 Prostacyclin synthase PTGIS 0.0025
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0025
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0025
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0025
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0024
6207 30S ribosomal protein S14 rpsN 0.0024
6209 30S ribosomal protein S19 rpsS 0.0024
6712 30S ribosomal protein S19 rpsS 0.0024
6726 30S ribosomal protein S19 rpsS 0.0024
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0023
2249 Aspartate aminotransferase aspC 0.0023
2671 Aspartate aminotransferase aspC 0.0023
5490 Aspartate aminotransferase Not Available 0.0023
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0023
1650 Heme carrier protein 1 SLC46A1 0.0023
6167 Organic solute transporter subunit beta OSTB 0.0023
4760 Mll3241 protein mll3241 0.0023
6166 Organic solute transporter subunit alpha OSTA 0.0023
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0021
1196 Complement decay-accelerating factor CD55 0.0021
6033 High affinity interleukin-8 receptor A CXCR1 0.0021
718 Folate receptor gamma FOLR3 0.0021
299 Folate receptor beta FOLR2 0.0021
804 Mitochondrial folate transporter/carrier SLC25A32 0.0021
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0021
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0021
527 Prostacyclin receptor PTGIR 0.0021
2300 Lysozyme E 0.0021
3633 Lysozyme R 0.0021
5597 Lysozyme 17 0.0021
672 Prostaglandin F2-alpha receptor PTGFR 0.002
146 Androgen receptor AR 0.002
5682 Ribonuclease pancreatic RNASE1 0.002
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.002
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.002
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.002
769 High-affinity choline transporter 1 SLC5A7 0.002
3933 Choline/ethanolaminephosphotransferase CEPT1 0.002
861 Choline kinase alpha CHKA 0.002
844 Epidermal growth factor receptor EGFR 0.002
700 Choline dehydrogenase, mitochondrial CHDH 0.002
3927 Choline transporter-like protein 3 SLC44A3 0.002
1686 Choline transporter-like protein 1 SLC44A1 0.002
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.002
3926 Choline transporter-like protein 2 SLC44A2 0.002
3925 Choline transporter-like protein 4 SLC44A4 0.002
576 Choline O-acetyltransferase CHAT 0.002
3922 Phospholipase D2 PLD2 0.002
3924 Phospholipase D1 PLD1 0.002
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.002
1714 Mitogen-activated protein kinase 3 MAPK3 0.0019
7 Nitric oxide synthase, inducible NOS2 0.0019
1654 Interleukin-1 beta IL1B 0.0019
291 Nitric-oxide synthase, endothelial NOS3 0.0019
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0019
2808 Chloramphenicol acetyltransferase 3 cat3 0.0019
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0018
1517 Beta-3 adrenergic receptor ADRB3 0.0018
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0018
153 Dopamine beta-hydroxylase DBH 0.0018
53 Solute carrier family 12 member 5 SLC12A5 0.0018
663 Solute carrier family 12 member 4 SLC12A4 0.0018
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0017
3947 Xanthine dehydrogenase/oxidase XDH 0.0017
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0017
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
2810 Dr hemagglutinin structural subunit draA 0.0017
489 Monocarboxylate transporter 2 SLC16A7 0.0017
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0017
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0017
751 Potassium channel subfamily K member 6 KCNK6 0.0017
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0017
310 Solute carrier family 12 member 2 SLC12A2 0.0017
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0016
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0016
459 Retinoic acid receptor RXR-alpha RXRA 0.0016
1360 Sphingomyelin phosphodiesterase SMPD1 0.0016
6031 Cytochrome P450 3A43 CYP3A43 0.0016
494 Caspase-1 CASP1 0.0015
172 Potassium channel subfamily K member 1 KCNK1 0.0015
183 Vascular endothelial growth factor A VEGFA 0.0015
1507 Cytochrome c CYCS 0.0015
4217 Telomerase reverse transcriptase TERT 0.0014
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0014
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0014
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0014
822 Aldose reductase AKR1B1 0.0014
2077 Caspase-3 CASP3 0.0013
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0013
702 UMP-CMP kinase CMPK1 0.0012
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0012
2981 Phospholipase A2, membrane associated PLA2G2A 0.0012
2021 Thrombomodulin THBD 0.0011
6432 Transporter snf 0.0011
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0011
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0011
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0011
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0011
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.001
1192 Sulfotransferase 1A1 SULT1A1 0.001
70 Type-1 angiotensin II receptor AGTR1 0.001
997 Protein kinase C beta type PRKCB 0.001
1275 Estrogen sulfotransferase SULT1E1 0.001
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.001
634 Squalene monooxygenase SQLE 0.001
7196 Squalene monooxygenase ERG1 0.001
1970 Protein kinase C alpha type PRKCA 0.001
1050 Bile salt sulfotransferase SULT2A1 0.001
6102 Arylamine N-acetyltransferase 2 NAT2 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0009
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0009
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0009
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0009
5818 Folate receptor alpha FOLR1 0.0008
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0008
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0008
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0008
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0008
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0008
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0008
6042 Prostaglandin reductase 2 PTGR2 0.0008
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0008
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0008
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0008
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0008
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0008
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0008
3587 Gastrotropin FABP6 0.0008
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0008
1792 Tissue-type plasminogen activator PLAT 0.0008
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0008
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0008
273 Apoptosis regulator Bcl-2 BCL2 0.0008
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0007
6085 Fatty acid-binding protein, intestinal FABP2 0.0007
2236 Casein kinase II subunit alpha CSNK2A1 0.0007
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0007
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0007
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0007
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0007
502 5-hydroxytryptamine 2A receptor HTR2A 0.0007
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0007
33 Cystine/glutamate transporter SLC7A11 0.0007
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0006
1313 Lactoylglutathione lyase GLO1 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0006
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0006
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0005
3811 Cytochrome P450 19A1 CYP19A1 0.0005
6020 Aldehyde oxidase AOX1 0.0005
136 Estrogen receptor ESR1 0.0005
365 Dihydrofolate reductase DHFR 0.0004
2381 Dihydrofolate reductase DFR1 0.0004
2833 Dihydrofolate reductase Not Available 0.0004
2931 Dihydrofolate reductase folA 0.0004
3544 Dihydrofolate reductase folA 0.0004
3682 Dihydrofolate reductase folA 0.0004
6642 Dihydrofolate reductase folA 0.0004
6756 Dihydrofolate reductase dfrA 0.0004
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