DT-Web: DB04552

Identification
Name	Niflumic Acid
Accession Number	DB04552 (EXPT02331)
Type	small molecule
Description	An analgesic and anti-inflammatory agent used in the treatment of rheumatoid arthritis. [PubChem]
Structure	MOL SDF PDB SMILES InChI
Categories ^(*)	Cyclooxygenase Inhibitors
Molecular Weight	282.218
Groups	approved
Monoisotopic Weight	282.061612157
Pharmacology
Indication	Used in the treatment of rheumatoid arthritis.
Mechanism of action	Niflumic acid is able to inhibit both phospholipase A2 as well as COX-2, thereby acting as an antiinflamatory and pain reduction agent.
Absorption	Well absorbed following oral administration.
Protein binding	90% bound to plasma proteins.
Biotransformation	Hepatic.
Route of elimination	Not Available
Toxicity	Oral, mouse: LD₅₀ = 350 mg/kg; Oral, rat: LD₅₀ = 250 mg/kg
Affected organisms	Humans and other mammals
Interactions
Drug Interactions	Not Available
Food Interactions	Not Available

Phospholipase A2
Name	Phospholipase A2
Gene Name	PLA2G1B
Pharmacological action	yes
Actions	inhibitor
References	Jabeen T, Singh N, Singh RK, Sharma S, Somvanshi RK, Dey S, Singh TP: Non-steroidal anti-inflammatory drugs as potent inhibitors of phospholipase A2: structure of the complex of phospholipase A2 with niflumic acid at 2.5 Angstroms resolution. Acta Crystallogr D Biol Crystallogr. 2005 Dec;61(Pt 12):1579-86. Epub 2005 Nov 19. - Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	1.2943
Prostaglandin G/H synthase 2
Name	Prostaglandin G/H synthase 2
Gene Name	PTGS2
Pharmacological action	yes
Actions	inhibitor
References	Jabeen T, Singh N, Singh RK, Sharma S, Somvanshi RK, Dey S, Singh TP: Non-steroidal anti-inflammatory drugs as potent inhibitors of phospholipase A2: structure of the complex of phospholipase A2 with niflumic acid at 2.5 Angstroms resolution. Acta Crystallogr D Biol Crystallogr. 2005 Dec;61(Pt 12):1579-86. Epub 2005 Nov 19. - Pubmed Diao HL, Zhu H, Ma H, Tan HN, Cong J, Su RW, Yang ZM: Rat ovulation, implantation and decidualization are severely compromised by COX-2 inhibitors. Front Biosci. 2007 May 1;12:3333-42. - Pubmed Alpert E, Gruzman A, Tennenbaum T, Sasson S: Selective cyclooxygenase-2 inhibitors stimulate glucose transport in L6 myotubes in a protein kinase Cdelta-dependent manner. Biochem Pharmacol. 2007 Feb 1;73(3):368-77. Epub 2006 Oct 13. - Pubmed
DTHybrid score	0.635
Chloride channel protein ClC-Ka
Name	Chloride channel protein ClC-Ka
Gene Name	CLCNKA
Pharmacological action	unknown
Actions	inducer
References	Picollo A, Liantonio A, Babini E, Camerino DC, Pusch M: Mechanism of interaction of niflumic acid with heterologously expressed kidney CLC-K chloride channels. J Membr Biol. 2007 Apr;216(2-3):73-82. Epub 2007 Jul 21. - Pubmed
DTHybrid score	0.3651
Prostaglandin G/H synthase 1
Name	Prostaglandin G/H synthase 1
Gene Name	PTGS1
Pharmacological action	unknown
Actions	Not Available
References	Talbot S, Lin JC, Lahjouji K, Roy JP, Senecal J, Morin A, Couture R: Cigarette smoke-induced kinin B1 receptor promotes NADPH oxidase activity in cultured human alveolar epithelial cells. Peptides. 2011 Jul;32(7):1447-56. Epub 2011 May 11. - Pubmed
DTHybrid score	0.6862
Cytosolic phospholipase A2
Name	Cytosolic phospholipase A2
Gene Name	PLA2G4A
Pharmacological action	unknown
Actions	Not Available
References	Jabeen T, Singh N, Singh RK, Sharma S, Somvanshi RK, Dey S, Singh TP: Non-steroidal anti-inflammatory drugs as potent inhibitors of phospholipase A2: structure of the complex of phospholipase A2 with niflumic acid at 2.5 Angstroms resolution. Acta Crystallogr D Biol Crystallogr. 2005 Dec;61(Pt 12):1579-86. Epub 2005 Nov 19. - Pubmed
DTHybrid score	0.5243
UDP-glucuronosyltransferase 1-9
Name	UDP-glucuronosyltransferase 1-9
Gene Name	UGT1A9
Pharmacological action	unknown
Actions	Not Available
References	Mano Y, Usui T, Kamimura H: In vitro inhibitory effects of non-steroidal anti-inflammatory drugs on 4-methylumbelliferone glucuronidation in recombinant human UDP-glucuronosyltransferase 1A9--potent inhibition by niflumic acid. Biopharm Drug Dispos. 2006 Jan;27(1):1-6. - Pubmed
DTHybrid score	0.3622

Monocarboxylate transporter 2
Name	Monocarboxylate transporter 2
Gene Name	SLC16A7
Actions	inhibitor
References	Broer S, Broer A, Schneider HP, Stegen C, Halestrap AP, Deitmer JW: Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes. Biochem J. 1999 Aug 1;341 ( Pt 3):529-35. - Pubmed
DTHybrid score	0.5539
Monocarboxylate transporter 1
Name	Monocarboxylate transporter 1
Gene Name	SLC16A1
Actions	inhibitor
References	Broer S, Broer A, Schneider HP, Stegen C, Halestrap AP, Deitmer JW: Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes. Biochem J. 1999 Aug 1;341 ( Pt 3):529-35. - Pubmed
DTHybrid score	0.5211

Id	Partner name	Gene Name	Score
500	Monocarboxylate transporter 4	SLC16A3	0.2522
4757	Cytochrome P450 2C9	CYP2C9	0.152
1729	Solute carrier family 22 member 6	SLC22A6	0.1281
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.1255
4512	Cytochrome P450 3A4	CYP3A4	0.1112
2616	Ganglioside GM2 activator	GM2A	0.0885
587	Serum albumin	ALB	0.0856
2929	(S)-2-haloacid dehalogenase	dhlB	0.0787
2995	(S)-2-haloacid dehalogenase	Not Available	0.0787
1193	Proteinase-activated receptor 1	F2R	0.0777
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0742
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.0723
4924	Cytochrome P450 2C8	CYP2C8	0.0722
1757	Myeloperoxidase	MPO	0.0669
6016	Cytochrome P450 2C19	CYP2C19	0.0629
1588	Multidrug resistance protein 1	ABCB1	0.0621
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0605
4200	Cytochrome P450 1A2	CYP1A2	0.0582
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0536
871	Glucocorticoid receptor	NR3C1	0.0525
275	Arachidonate 5-lipoxygenase	ALOX5	0.0522
3184	3-methyl-2-oxobutanoate hydroxymethyltransferase	panB	0.0512
3315	3-methyl-2-oxobutanoate hydroxymethyltransferase	panB	0.0512
3179	2-isopropylmalate synthase	leuA	0.0512
232	Corticosteroid-binding globulin	SERPINA6	0.0471
6142	Solute carrier family 22 member 8	SLC22A8	0.0466
5650	NimA-related protein	DR_0842	0.045
234	Plasminogen	PLG	0.0448
4118	Cytochrome P450 3A5	CYP3A5	0.0442
862	Multidrug resistance-associated protein 1	ABCC1	0.0428
2164	Multidrug resistance-associated protein 4	ABCC4	0.0421
3334	Deacetoxycephalosporin C synthetase	cefE	0.0408
4615	Chain A, Red Copper Protein Nitrosocyanin	NE0143	0.0389
4119	Cytochrome P450 2D6	CYP2D6	0.0379
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.0376
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.0361
1024	Solute carrier family 22 member 11	SLC22A11	0.0358
3254	Bifunctional protein putA [Includes: Proline dehydrogenase	putA	0.0356
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0347
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0344
2751	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0339
4755	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0339
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0338
6020	Aldehyde oxidase	AOX1	0.0336
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.033
6143	Solute carrier family 22 member 7	SLC22A7	0.0323
3823	Cytokine receptor common gamma chain	IL2RG	0.0314
6013	Cytochrome P450 2E1	CYP2E1	0.0307
795	Branched-chain-amino-acid aminotransferase, mitochondrial	BCAT2	0.0305
6116	Gastric triacylglycerol lipase	LIPF	0.0301
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0286
1758	GTPase HRas	HRAS	0.0282
6151	Monocarboxylate transporter 10	SLC16A10	0.0281
1295	Fatty acid synthase	FASN	0.028
724	Interleukin-2 receptor alpha chain	IL2RA	0.0274
717	Interleukin-2 receptor subunit beta	IL2RB	0.0274
754	Pancreatic triacylglycerol lipase	PNLIP	0.0268
6107	Cytochrome P450 3A7	CYP3A7	0.0264
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.0259
6139	Solute carrier organic anion transporter family member 1A2	SLCO1A2	0.0254
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0227
3810	Catechol O-methyltransferase	COMT	0.0223
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0221
5718	Cytochrome P450 2A6	CYP2A6	0.022
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0219
118	Organic cation/carnitine transporter 2	SLC22A5	0.0212
6102	Arylamine N-acetyltransferase 2	NAT2	0.0211
1770	Phospholipase C	PLCL1	0.0206
2841	Phospholipase C	plc	0.0206
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0206
1490	Solute carrier organic anion transporter family member 1B1	SLCO1B1	0.0203
6030	Cytochrome P450 2B6	CYP2B6	0.0202
6024	Cytochrome P450 1A1	CYP1A1	0.0201
3312	Fatty acid-binding protein, brain	FABP7	0.0199
4165	P2Y purinoceptor 2	P2RY2	0.0198
2300	Lysozyme	E	0.0194
3633	Lysozyme	R	0.0194
5597	Lysozyme	17	0.0194
4604	Liver carboxylesterase 1	CES1	0.0193
817	DNA topoisomerase 2-alpha	TOP2A	0.0192
1159	Interleukin-6	IL6	0.0185
3947	Xanthine dehydrogenase/oxidase	XDH	0.0185
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0184
6837	Serine/threonine-protein kinase 17B	STK17B	0.0183
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0183
3923	Cholinesterase	BCHE	0.0183
6144	Solute carrier family 22 member 2	SLC22A2	0.0181
430	Follicle-stimulating hormone receptor	FSHR	0.0179
397	Monocarboxylate transporter 3	SLC16A8	0.0178
195	Monocarboxylate transporter 7	SLC16A6	0.0177
429	Monocarboxylate transporter 6	SLC16A5	0.0177
218	Monocarboxylate transporter 5	SLC16A4	0.0177
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0177
6149	Solute carrier family 22 member 10	SLC22A10	0.0177
6106	Cytochrome P450 2C18	CYP2C18	0.0176
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0175
737	Mineralocorticoid receptor	NR3C2	0.0174
52	Pyruvate kinase isozymes R/L	PKLR	0.0164
3866	Serum amyloid A protein	SAA1	0.0163
1200	AMBP protein	AMBP	0.0163
1932	Apolipoprotein E	APOE	0.0163
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0162
2654	Complement control protein	C3L	0.0161
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.0161
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.0159
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0159
373	Transthyretin	TTR	0.0159
6141	Sodium/bile acid cotransporter	SLC10A1	0.0159
614	Progesterone receptor	PGR	0.0156
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0154
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.0153
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.015
771	Pyruvate carboxylase, mitochondrial	PC	0.0149
338	DNA polymerase	UL30	0.0149
379	DNA polymerase	UL54	0.0149
697	DNA polymerase	ORF28	0.0149
2482	DNA polymerase	43	0.0149
4104	DNA polymerase	BALF5	0.0149
98	Pyruvate kinase isozymes M1/M2	PKM2	0.0148
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0147
5455	Arylsulfatase A	ARSA	0.0146
814	Ryanodine receptor 1	RYR1	0.0146
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0144
4203	Histamine N-methyltransferase	HNMT	0.0143
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0141
2599	Tyrosine-protein kinase HCK	HCK	0.0139
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0139
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0139
54	Prothrombin	F2	0.0136
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0135
672	Prostaglandin F2-alpha receptor	PTGFR	0.0135
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0133
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0133
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0133
703	NADPH azoreductase	azr	0.0132
114	Alanine--glyoxylate aminotransferase 2, mitochondrial	AGXT2	0.013
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0126
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0125
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0125
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0124
467	Delta-type opioid receptor	OPRD1	0.0124
696	Kappa-type opioid receptor	OPRK1	0.0123
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.0123
850	Vasopressin V1b receptor	AVPR1B	0.0122
1439	Lactotransferrin	LTF	0.0122
6137	Multidrug resistance-associated protein 6	ABCC6	0.0121
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0121
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.012
847	Mu-type opioid receptor	OPRM1	0.0118
199	Monocarboxylate transporter 8	SLC16A2	0.0117
777	Tumor necrosis factor	TNF	0.0117
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0116
853	Farnesyl pyrophosphate synthetase	FDPS	0.0113
1507	Cytochrome c	CYCS	0.0111
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0111
185	Vasopressin V1a receptor	AVPR1A	0.0107
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0106
322	Vasopressin V2 receptor	AVPR2	0.0105
928	Nicotinic acid receptor 2	GPR109B	0.0105
860	Nicotinamide N-methyltransferase	NNMT	0.0105
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0105
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0105
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0105
699	Nicotinic acid receptor 1	GPR109A	0.0105
6103	Arylamine N-acetyltransferase 1	NAT1	0.0104
6218	Pannexin-1	PANX1	0.0101
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0098
6043	Putative G-protein coupled receptor 44	GPR44	0.0098
6145	Solute carrier family 22 member 1	SLC22A1	0.0097
6220	Aryl hydrocarbon receptor	AHR	0.0094
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0093
137	FolC bifunctional protein [Includes: Folylpolyglutamate synthase	folC	0.0091
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0091
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.009
459	Retinoic acid receptor RXR-alpha	RXRA	0.0089
3587	Gastrotropin	FABP6	0.0089
146	Androgen receptor	AR	0.0089
782	ADP/ATP translocase 2	SLC25A5	0.0086
688	ADP/ATP translocase 3	SLC25A6	0.0086
4164	Potassium voltage-gated channel subfamily KQT member 5	KCNQ5	0.0083
4163	Potassium voltage-gated channel subfamily KQT member 4	KCNQ4	0.0083
1648	Elastin	ELN	0.0082
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0081
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0081
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0081
61	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0079
2644	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0079
2710	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	folK	0.0079
776	Bile salt export pump	ABCB11	0.0079
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0078
4221	Vascular endothelial growth factor	VEGF	0.0075
5816	Cadherin-5	CDH5	0.0075
33	Cystine/glutamate transporter	SLC7A11	0.0074
1039	Histone deacetylase 9	HDAC9	0.0074
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0072
823	Fibroblast growth factor receptor 2	FGFR2	0.0071
6085	Fatty acid-binding protein, intestinal	FABP2	0.007
1650	Heme carrier protein 1	SLC46A1	0.0069
2391	Ferrochelatase	hemH	0.0069
6502	Ferrochelatase	DKFZp686P18130	0.0069
1591	Ferrochelatase, mitochondrial	FECH	0.0069
891	Dihydropteroate synthase	folP	0.0067
5359	Dihydropteroate synthase	folP	0.0067
7175	Dihydropteroate synthase	sulI	0.0067
543	Penicillin-binding protein 1B	mrcB	0.0067
6186	Penicillin-binding protein 1B	ponB	0.0067
6822	Penicillin-binding protein 1b	pbp1b	0.0067
6844	Penicillin-binding protein 1b	pbp1b	0.0067
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0066
130	Prostacyclin synthase	PTGIS	0.0065
645	Penicillin-binding protein 1A	mrcA	0.0065
5805	Penicillin-binding protein 1A	ponA	0.0065
6185	Penicillin-binding protein 1A	mrcA	0.0065
6799	Penicillin-binding protein 1A	pbpA	0.0065
3809	Estrogen-related receptor gamma	ESRRG	0.0065
661	ADP/ATP translocase 1	SLC25A4	0.0064
6136	Multidrug resistance-associated protein 5	ABCC5	0.0064
3014	Ribonuclease UK114	HRSP12	0.0064
5428	Replication protein	repA	0.0064
3617	Non-heme chloroperoxidase	cpo	0.0064
5426	Non-heme chloroperoxidase	cpo	0.0064
5427	Hydroxyquinol 1,2-dioxygenase	chqB	0.0064
3718	Hydrogen peroxide-inducible genes activator	oxyR	0.0064
3018	HTH-type transcriptional regulator malT	malT	0.0064
159	Penicillin-binding protein 2B	penA	0.0064
6121	Penicillin-binding protein 2B	penA	0.0064
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0064
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0064
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0064
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0062
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0062
2021	Thrombomodulin	THBD	0.0062
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.006
134	Tryptophan 5-hydroxylase 1	TPH1	0.006
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.006
6493	Cytochrome c oxidase subunit 6C	COX6C	0.006
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.006
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.006
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.006
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.006
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.006
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.006
6559	Cytochrome c oxidase subunit 2	ctaC	0.006
6669	Cytochrome c oxidase subunit 2	ctaC	0.006
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.006
371	Cytochrome c oxidase subunit 1	MT-CO1	0.006
6558	Cytochrome c oxidase subunit 1	ctaD	0.006
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.006
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.006
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0059
1192	Sulfotransferase 1A1	SULT1A1	0.0059
3811	Cytochrome P450 19A1	CYP19A1	0.0058
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0056
759	Free fatty acid receptor 1	FFAR1	0.0056
1818	Long-chain-fatty-acid--CoA ligase 3	ACSL3	0.0056
1275	Estrogen sulfotransferase	SULT1E1	0.0056
6033	High affinity interleukin-8 receptor A	CXCR1	0.0056
6148	Multidrug resistance-associated protein 7	ABCC10	0.0056
2540	Choloylglycine hydrolase	cbh	0.0055
2958	Probable tautomerase ydcE	pptA	0.0055
2573	Cocaine esterase	cocE	0.0055
7263	Cocaine esterase	Not Available	0.0055
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0054
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0054
1050	Bile salt sulfotransferase	SULT2A1	0.0054
3603	Chlorocatechol 1,2-dioxygenase	clcA	0.0054
3115	Ras-related protein Rab-9	RAB9A	0.0054
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0054
676	Tyrosine 3-monooxygenase	TH	0.0054
1898	Cytochrome P450 1B1	CYP1B1	0.0054
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0053
558	Solute carrier family 12 member 1	SLC12A1	0.0053
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0052
6501	Fatty acid-binding protein, liver	FABP1	0.0052
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0052
4787	Envelope glycoprotein gp160	env	0.0052
4820	Envelope glycoprotein gp160	env	0.0052
5727	Envelope glycoprotein gp160	env	0.0052
1714	Mitogen-activated protein kinase 3	MAPK3	0.005
504	Mast/stem cell growth factor receptor	KIT	0.0049
26	Vascular endothelial growth factor receptor 3	FLT4	0.0049
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0049
1053	BC269730_2	FADS1	0.0049
1395	Sodium/calcium exchanger 1	SLC8A1	0.0049
828	Phenylalanine-4-hydroxylase	PAH	0.0049
3109	Phenylalanine-4-hydroxylase	phhA	0.0049
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0048
70	Type-1 angiotensin II receptor	AGTR1	0.0048
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0048
32	Vascular endothelial growth factor receptor 1	FLT1	0.0047
6042	Prostaglandin reductase 2	PTGR2	0.0047
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0047
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0046
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0046
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0045
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0045
1656	CYP2B protein	CYP2B	0.0045
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0045
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0044
3601	Dihydropteroate synthase 1	folP1	0.0044
3807	Dihydropteroate synthase 1	folP1	0.0044
3808	Dihydropteroate synthase 2	folP2	0.0044
3814	Complement C1r subcomponent	C1R	0.0044
1792	Tissue-type plasminogen activator	PLAT	0.0043
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0043
273	Apoptosis regulator Bcl-2	BCL2	0.0042
4878	Glycoprotein hormones alpha chain	CGA	0.0042
2236	Casein kinase II subunit alpha	CSNK2A1	0.0042
4877	Beta-mannanase	man	0.0042
4850	Beta-2-glycoprotein 1	APOH	0.0042
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.0042
4880	Membrane cofactor protein	CD46	0.0042
1072	Granzyme B	GZMB	0.0042
4889	Ig epsilon chain C region	IGHE	0.0042
4189	Alpha-galactosidase A	GLA	0.0042
4869	Major capsid protein	A430L	0.0042
4852	Reticulon-4 receptor	RTN4R	0.0042
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.0042
757	Fusion glycoprotein F0	F	0.0042
4875	Fusion glycoprotein F0	F	0.0042
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.0042
442	Envelope glycoprotein	gp41	0.0042
4859	Envelope glycoprotein	env	0.0042
4856	CD209 antigen	CD209	0.0042
4721	Beta-1,4-mannanase	manA	0.0042
4845	ADAM 33	ADAM33	0.0042
1354	Beta-glucuronidase	GUSB	0.0042
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.0042
3352	Structural polyprotein	Not Available	0.0042
3628	Structural polyprotein	Not Available	0.0042
4892	Structural polyprotein	Not Available	0.0042
2693	Heat-labile enterotoxin B chain	eltB	0.0042
6645	D-amino-acid oxidase	DAO	0.0041
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.004
811	Translocator protein	TSPO	0.004
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.004
291	Nitric-oxide synthase, endothelial	NOS3	0.004
7	Nitric oxide synthase, inducible	NOS2	0.004
1184	Interferon beta	IFNB1	0.0039
824	Sodium-dependent serotonin transporter	SLC6A4	0.0039
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0038
407	Vascular endothelial growth factor receptor 2	KDR	0.0038
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0038
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0038
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0038
2853	14 kDa fatty acid-binding protein	Not Available	0.0037
1789	Lymphotoxin-alpha	LTA	0.0037
1269	Tumor necrosis factor receptor superfamily member 1B	TNFRSF1B	0.0037
2207	Rhodopsin	RHO	0.0037
793	T-cell surface antigen CD2	CD2	0.0036
4861	Interleukin-6 receptor alpha chain	IL6R	0.0036
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0036
3837	Cytokine receptor common beta chain	CSF2RB	0.0036
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0036
1313	Lactoylglutathione lyase	GLO1	0.0036
517	Alcohol dehydrogenase 1C	ADH1C	0.0036
822	Aldose reductase	AKR1B1	0.0036
1379	Interleukin-12 subunit beta	IL12B	0.0036
4890	Hemagglutinin	HA	0.0036
6566	Hemagglutinin	Not Available	0.0036
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0036
6858	Inactive carboxylesterase 4	CES1P1	0.0036
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0035
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0035
908	Glutathione S-transferase theta-1	GSTT1	0.0034
1618	High affinity nerve growth factor receptor	NTRK1	0.0034
4785	Ig gamma-1 chain C region	IGHG1	0.0034
4666	Fucose-binding lectin PA-IIL	lecB	0.0034
831	D(2) dopamine receptor	DRD2	0.0034
2372	Bifunctional tail protein	9	0.0033
5798	Mitogen-activated protein kinase 11	MAPK11	0.0033
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0033
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0033
1859	Prostatic acid phosphatase	ACPP	0.0033
3444	Cyanovirin-N	Not Available	0.0033
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0033
3140	Hemagglutinin-neuraminidase	HN	0.0033
3609	Hemagglutinin-neuraminidase	HN	0.0033
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0032
4784	Beta-mannosidase	manB	0.0032
6695	Beta-mannosidase	BT_0458	0.0032
1353	DNA topoisomerase 1	TOP1	0.0032
3552	DNA topoisomerase 1	topA	0.0032
833	Organic cation/carnitine transporter 1	SLC22A4	0.0031
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.003
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.003
267	Plasminogen activator inhibitor 1	SERPINE1	0.003
5818	Folate receptor alpha	FOLR1	0.003
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.003
554	Low-density lipoprotein receptor	LDLR	0.003
852	Heparin cofactor 2	SERPIND1	0.0029
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0029
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0029
6221	Steroid hormone receptor ERR1	ESRRA	0.0029
64	Neuraminidase	NA	0.0028
641	Neuraminidase	NA	0.0028
2676	Neuraminidase	NA	0.0028
3026	Neuraminidase	NA	0.0028
3519	Neuraminidase	NA	0.0028
6007	Neuraminidase	NA	0.0028
2430	Chondroitinase B	cslB	0.0028
904	Glutathione S-transferase P	GSTP1	0.0028
595	Fibrinogen alpha chain	FGA	0.0027
1243	Cathepsin D	CTSD	0.0027
6167	Organic solute transporter subunit beta	OSTB	0.0027
6166	Organic solute transporter subunit alpha	OSTA	0.0027
958	Insulin-like growth factor 1 receptor	IGF1R	0.0026
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0026
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0026
293	Gamma-glutamyl hydrolase	GGH	0.0026
3937	Fatty-acid amide hydrolase	FAAH	0.0026
2183	Fatty acid-binding protein, adipocyte	FABP4	0.0026
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0026
663	Solute carrier family 12 member 4	SLC12A4	0.0026
53	Solute carrier family 12 member 5	SLC12A5	0.0026
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0026
6146	High affinity copper uptake protein 1	SLC31A1	0.0026
427	Substance-P receptor	TACR1	0.0025
6307	Ig gamma-2 chain C region	IGHG2	0.0025
2581	Chondroitinase AC	cslA	0.0025
936	Ephrin type-A receptor 2	EPHA2	0.0025
5787	Angiopoietin-1 receptor	TEK	0.0025
4192	DNA topoisomerase 2-beta	TOP2B	0.0025
165	FL cytokine receptor	FLT3	0.0025
6847	Lactase-phlorizin hydrolase	LCT	0.0024
310	Solute carrier family 12 member 2	SLC12A2	0.0024
638	D(3) dopamine receptor	DRD3	0.0024
106	Cannabinoid receptor 2	CNR2	0.0024
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0024
2297	Genome polyprotein	Not Available	0.0024
2322	Genome polyprotein	Not Available	0.0024
2694	Genome polyprotein	Not Available	0.0024
2719	Genome polyprotein	Not Available	0.0024
2860	Genome polyprotein	Not Available	0.0024
2928	Genome polyprotein	Not Available	0.0024
3160	Genome polyprotein	Not Available	0.0024
3260	Genome polyprotein	Not Available	0.0024
4783	Genome polyprotein	Not Available	0.0024
5726	Genome polyprotein	Not Available	0.0024
5779	Genome polyprotein	Not Available	0.0024
5867	Genome polyprotein	Not Available	0.0024
6253	Genome polyprotein	Not Available	0.0024
6301	Genome polyprotein	Not Available	0.0024
6380	Genome polyprotein	Not Available	0.0024
6381	Genome polyprotein	Not Available	0.0024
6437	Genome polyprotein	Not Available	0.0024
6520	Genome polyprotein	Not Available	0.0024
6521	Genome polyprotein	Not Available	0.0024
6652	Genome polyprotein	Not Available	0.0024
6734	Genome polyprotein	Not Available	0.0024
6735	Genome polyprotein	Not Available	0.0024
6736	Genome polyprotein	Not Available	0.0024
6737	Genome polyprotein	Not Available	0.0024
6738	Genome polyprotein	Not Available	0.0024
6739	Genome polyprotein	Not Available	0.0024
6744	Genome polyprotein	Not Available	0.0024
6748	Genome polyprotein	Not Available	0.0024
6894	Genome polyprotein	Not Available	0.0024
6898	Genome polyprotein	Not Available	0.0024
1629	Transcription factor AP-1	JUN	0.0024
76	Nitric-oxide synthase, brain	NOS1	0.0024
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0023
68	Cannabinoid receptor 1	CNR1	0.0023
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0023
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0023
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0023
309	Antithrombin-III	SERPINC1	0.0022
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0022
2782	Complement C1s subcomponent	C1S	0.0022
6147	Solute carrier family 22 member 3	SLC22A3	0.0022
634	Squalene monooxygenase	SQLE	0.0022
7196	Squalene monooxygenase	ERG1	0.0022
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.0022
23	D(1A) dopamine receptor	DRD1	0.0022
3437	Eosinophil lysophospholipase	CLC	0.0021
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0021
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0021
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0021
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0021
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0021
3817	Complement C1q subcomponent subunit C	C1QC	0.0021
3815	Complement C1q subcomponent subunit A	C1QA	0.0021
3816	Complement C1q subcomponent subunit B	C1QB	0.0021
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0021
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0021
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0021
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0021
1102	Low affinity immunoglobulin gamma Fc region receptor III-B	FCGR3B	0.0021
3818	Low affinity immunoglobulin gamma Fc region receptor III-A	FCGR3A	0.0021
3819	Low affinity immunoglobulin gamma Fc region receptor II-a	FCGR2A	0.0021
3821	Low affinity immunoglobulin gamma Fc region receptor II-c	FCGR2C	0.0021
3820	Low affinity immunoglobulin gamma Fc region receptor II-b	FCGR2B	0.002
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.002
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.002
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.002
6014	Cytochrome P450 2A13	CYP2A13	0.002
784	High affinity immunoglobulin gamma Fc receptor I	FCGR1A	0.0019
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0019
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0019
260	Cytochrome P450 51	ERG11	0.0019
761	Cytochrome P450 51	ERG11	0.0019
3163	Cytochrome P450 51	cyp51	0.0019
6131	Carbonic anhydrase 14	CA14	0.0019
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0019
6031	Cytochrome P450 3A43	CYP3A43	0.0018
952	Dipeptidyl peptidase 4	DPP4	0.0018
24	Thymidylate synthase	TMP1	0.0018
359	Thymidylate synthase	TYMS	0.0018
2626	Thymidylate synthase	thyA	0.0018
2729	Thymidylate synthase	thyA	0.0018
5352	Thymidylate synthase	THYA	0.0018
365	Dihydrofolate reductase	DHFR	0.0018
2381	Dihydrofolate reductase	DFR1	0.0018
2833	Dihydrofolate reductase	Not Available	0.0018
2931	Dihydrofolate reductase	folA	0.0018
3544	Dihydrofolate reductase	folA	0.0018
3682	Dihydrofolate reductase	folA	0.0018
6642	Dihydrofolate reductase	folA	0.0018
6756	Dihydrofolate reductase	dfrA	0.0018
492	Histamine H1 receptor	HRH1	0.0016
4103	Proteasome subunit beta type 2	PSMB2	0.0016
4102	Proteasome subunit beta type 5	PSMB5	0.0016
4101	Proteasome subunit beta type 1	PSMB1	0.0016
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0016
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0016
1374	Natriuretic peptides B	NPPB	0.0015
1827	Gap junction alpha-1 protein	GJA1	0.0015
1908	Vascular cell adhesion protein 1	VCAM1	0.0015
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0015
921	Glutamate receptor 2	GRIA2	0.0015
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0015
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0014
4024	Mitochondrial glutamate carrier 2	SLC25A18	0.0013
4025	Mitochondrial glutamate carrier 1	SLC25A22	0.0013
1912	Excitatory amino acid transporter 1	SLC1A3	0.0013
4019	Excitatory amino acid transporter 4	SLC1A6	0.0013
922	Glutamate receptor 4	GRIA4	0.0013
4021	Probable glutamyl-tRNA synthetase, mitochondrial	EARS2	0.0013
4026	Aspartyl aminopeptidase	DNPEP	0.0013
4022	Glutamate--ammonia ligase domain-containing protein 1	LGSN	0.0013
4023	N-acetylglutamate synthase, mitochondrial	NAGS	0.0013
4016	Excitatory amino acid transporter 5	SLC1A7	0.0013
1047	Excitatory amino acid transporter 2	SLC1A2	0.0013
927	Metabotropic glutamate receptor 8	GRM8	0.0013
664	Glutamate decarboxylase 2	GAD2	0.0013
3890	Glutamate decarboxylase 2	GAD2	0.0013
4020	Glutamyl aminopeptidase	ENPEP	0.0013
4018	Glutamate receptor delta-2 subunit	GRID2	0.0013
915	Delta 1-pyrroline-5-carboxylate synthetase	ALDH18A1	0.0013
925	Metabotropic glutamate receptor 4	GRM4	0.0013
926	Metabotropic glutamate receptor 7	GRM7	0.0013
924	Glutamate receptor, ionotropic kainate 3	GRIK3	0.0013
919	Glutamate receptor, ionotropic kainate 4	GRIK4	0.0013
4027	Glutamate receptor delta-1 subunit	GRID1	0.0013
920	Glutamate receptor, ionotropic kainate 5	GRIK5	0.0013
4017	5-oxoprolinase	OPLAH	0.0013
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0013
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0013
625	Glutamate carboxypeptidase 2	FOLH1	0.0012
716	5-hydroxytryptamine 7 receptor	HTR7	0.0012
183	Vascular endothelial growth factor A	VEGFA	0.0012
6163	Copper-transporting ATPase 2	ATP7B	0.0012
6165	Copper-transporting ATPase 1	ATP7A	0.0012
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0012
556	Alpha-1A adrenergic receptor	ADRA1A	0.0012
668	Glutamate--cysteine ligase regulatory subunit	GCLM	0.0012
3991	Glutamine-dependent NAD(+) synthetase	NADSYN1	0.0011
3984	Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial	PET112L	0.0011
5	Glutaminase liver isoform, mitochondrial	GLS2	0.0011
917	Glutaminase kidney isoform, mitochondrial	GLS	0.0011
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0011
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0011
3982	Phosphoribosylformylglycinamidine synthase	PFAS	0.0011
5261	Phosphoribosylformylglycinamidine synthase	purL	0.0011
1864	RET proto-oncogene	RET	0.0011
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0011
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0011
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0011
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0011
916	Metabotropic glutamate receptor 1	GRM1	0.0011
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0011
665	Phosphoserine aminotransferase	PSAT1	0.0011
4652	Phosphoserine aminotransferase	serC	0.0011
801	Kynurenine/alpha-aminoadipate aminotransferase mitochondrial	AADAT	0.0011
3895	Kynurenine--oxoglutarate transaminase 3	CCBL2	0.0011
420	Glutamate decarboxylase 1	GAD1	0.0011
3900	Glutamate decarboxylase 1	GAD1	0.0011
382	Glutamate receptor, ionotropic kainate 1	GRIK1	0.0011
923	Glutamate receptor 3	GRIA3	0.0011
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0011
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0011
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.001
1671	Excitatory amino acid transporter 3	SLC1A1	0.001
725	5-hydroxytryptamine 1D receptor	HTR1D	0.001
210	Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase	EPRS	0.001
885	5-hydroxytryptamine 1B receptor	HTR1B	0.001
186	Glutamate--cysteine ligase catalytic subunit	GCLC	0.001
3877	Growth-inhibiting protein 18	GIG18	0.001
426	Aspartate aminotransferase, mitochondrial	GOT2	0.001
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.001
468	Cytochrome P450 4A11	CYP4A11	0.001
896	Glutathione S-transferase Mu 1	GSTM1	0.001
763	Tyrosine aminotransferase	TAT	0.001
5493	Tyrosine aminotransferase	Not Available	0.001
735	Alanine aminotransferase 1	GPT	0.001
3904	Alanine aminotransferase 2	GPT2	0.001
586	Aspartate aminotransferase, cytoplasmic	GOT1	0.001
505	Glutamate [NMDA] receptor subunit epsilon-3	GRIN2C	0.001
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.001
439	Glutamate [NMDA] receptor subunit epsilon-4	GRIN2D	0.0009
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0009
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0009
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0009
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0009
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0009
574	Branched-chain-amino-acid aminotransferase, cytosolic	BCAT1	0.0009
591	Glutamate [NMDA] receptor subunit 3B	GRIN3B	0.0009
705	Glutamate receptor 1	GRIA1	0.0009
3426	Glutamine synthetase	glnA	0.0009
3987	Glutamine synthetase	GLUL	0.0009
4943	Cytochrome c6	petJ	0.0009
4905	Cytochrome c2	Not Available	0.0009
4939	Cytochrome c2	cycA	0.0009
4964	Cytochrome c2	cycA	0.0009
4979	Cytochrome c2	cycA	0.0009
6673	Cytochrome c2	cycA	0.0009
4954	Soluble cytochrome b558	Not Available	0.0009
4984	Neuroglobin	NGB	0.0009
4934	Cytochrome c-551	nirM	0.0009
5218	Cytochrome c-551	nirM	0.0009
4994	Hemoglobin-like protein HbO	glbO	0.0009
4925	Cytochrome c-type protein SHP	shp	0.0009
4947	Bacterial hemoglobin	vhb	0.0009
4942	Diheme cytochrome c napB	napB	0.0009
4998	Hemoglobin-like protein yjbI	yjbI	0.0009
4916	Cyanoglobin	glbN	0.0009
4915	Cytochrome c-550	psbV	0.0009
4959	Cytochrome c-550	psbV	0.0009
5216	Cytochrome c-550	psbV	0.0009
4961	Hemophore HasA	hasA	0.0009
4975	Cytochrome c-556	RPA3973	0.0009
4936	Cytochrome c2 iso-2	Not Available	0.0009
4910	Cytoglobin	CYGB	0.0008
644	Heme oxygenase 2	HMOX2	0.0008
4982	Heme oxygenase 2	pbsA2	0.0008
4904	Cytochrome c family protein	GSU1996	0.0008
4981	Iron-starvation protein PigA	pigA	0.0008
4976	Apocytochrome f	petA	0.0008
6407	Apocytochrome f	petA	0.0008
3116	Bacterioferritin	bfr	0.0008
4906	Bacterioferritin	bfr	0.0008
4965	Bacterioferritin	bfr	0.0008
5000	HemO	hemO	0.0008
4907	Cytochrome c-L	moxG	0.0008
6865	Cytochrome c-L	moxG	0.0008
4909	CooA protein	cooA	0.0008
4764	Cytochrome P450 165C4	CYP165C4	0.0008
4971	Nonaheme cytochrome c	hmcA	0.0008
4989	Cytochrome c551 peroxidase	ccp	0.0008
5222	Cytochrome c551 peroxidase	ccpA	0.0008
4926	Heme-based aerotactic transducer hemAT	hemAT	0.0008
4937	Cytochrome oxidase subunit II	rcoxA	0.0008
4999	Cytochrome P450 165B3	CYP165B3	0.0008
4972	P450cin	cinA	0.0008
4960	Putative cytochrome P450-family protein	SCO7417	0.0008
4935	Cytochrome c-554	cycA1	0.0008
4931	Cytochrome P450 167A1	CYP167A1	0.0008
4993	Hydroxylamine oxidoreductase	hao1	0.0008
4952	Catalase/peroxidase	katA	0.0008
4970	Cytochrome c nitrite reductase catalytic subunit	nrfA	0.0008
4922	Cytochrome c, putative	SO_4144	0.0008
4903	Methyl-accepting chemotaxis protein	Tar4	0.0008
3093	Catalase HPII	katE	0.0008
4908	Heme-regulated cyclic AMP phosphodiesterase	dosP	0.0008
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0008
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0008
193	Beta-1 adrenergic receptor	ADRB1	0.0008
766	Beta-2 adrenergic receptor	ADRB2	0.0007
789	Alpha-1D adrenergic receptor	ADRA1D	0.0007
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0006
4920	Peroxidase/catalase	katG	0.0006
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0006
4956	Quinohemoprotein alcohol dehydrogenase ADH IIB	qbdA	0.0006
4037	Hypothetical protein	GPX1	0.0006
4297	Hypothetical protein	SP_1951	0.0006
4521	Hypothetical protein	BC_2969	0.0006
4540	Hypothetical protein	TM_1070	0.0006
4555	Hypothetical protein	MT1739	0.0006
4569	Hypothetical protein	mshD	0.0006
4578	Hypothetical protein	PA3270	0.0006
4747	Hypothetical protein	PA3967	0.0006
5177	Hypothetical protein	TM_0096	0.0006
5194	Hypothetical protein	PA1204	0.0006
5240	Hypothetical protein	Rv2991	0.0006
5370	Hypothetical protein	TM_1158	0.0006
5710	Hypothetical protein	Tb927.5.1360	0.0006
4923	Cytochrome c3	DvMF_2499	0.0006
4945	Cytochrome c3	Not Available	0.0006
4949	Cytochrome c3	DVU_3171	0.0006
4968	Cytochrome c3	cytc3	0.0006
4997	Cytochrome c3	SO_2727	0.0006
5219	Cytochrome c3	cyd	0.0006
4948	Cytochrome c-553	Not Available	0.0006
2119	Cytochrome b5	CYB5A	0.0006
3189	High-molecular-weight cytochrome c	hmcA	0.0006
4902	Nine-heme cytochrome c	Ddes_2038	0.0006
4289	Cytochrome P450	TT_P0059	0.0006
6262	Cytochrome P450	staP	0.0006
4990	PpcA	ppcA	0.0006
4992	Cytochrome c peroxidase	Not Available	0.0006
3570	Cytochrome P450 152A1	cypC	0.0006
4988	Sulfite oxidase, mitochondrial	SUOX	0.0006
2915	Sensor protein fixL	fixL	0.0006
4944	Sensor protein fixL	fixL	0.0006
3375	Acidic cytochrome c3	Not Available	0.0006
4385	Cytochrome c'	Not Available	0.0006
4967	Cytochrome c'	cycA	0.0006
5038	Cytochrome c'	Not Available	0.0006
5223	Cytochrome c'	cycP	0.0006
4813	Heme oxygenase	hmuO	0.0006
5769	Heme oxygenase	Not Available	0.0006
2230	Catalase	CAT	0.0006
3249	Catalase	katA	0.0006
3625	Catalase	katA	0.0006
4539	Catalase	katA	0.0006
4941	Catalase	katB	0.0006
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0006
3670	Soluble cytochrome b562 precursor	cybC	0.0006
3411	Cytochrome P450 121	cyp121	0.0006
2617	Nitric oxide synthase oxygenase	nos	0.0006
2701	Nitric oxide synthase oxygenase	nos	0.0006
3291	Cytochrome c-552	cycA	0.0005
4927	Cytochrome c-552	nrfA	0.0005
4938	Cytochrome c-552	cycA	0.0005
4953	Cytochrome c-552	nrfA	0.0005
5217	Cytochrome c-552	cycM	0.0005
4386	Hemoglobin-like protein HbN	glbN	0.0005
3102	Flavohemoprotein	hmp	0.0005
4969	Flavohemoprotein	hmp	0.0005
518	Peroxidase/catalase T	katG	0.0005
3127	Nitrite reductase	nirS	0.0005
3284	Nitrite reductase	nirS	0.0005
2845	Bifunctional P-450:NADPH-P450 reductase	CYP102A1	0.0005
3221	Cytochrome c4	cc4	0.0005
605	Fumarate reductase flavoprotein subunit	frdA	0.0005
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0005
3673	Fumarate reductase flavoprotein subunit	fccA	0.0005
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0005
6549	Fumarate reductase flavoprotein subunit	frdA	0.0005
2972	6-deoxyerythronolide B hydroxylase	eryF	0.0005
4608	Putative cytochrome P450	SCO1207	0.0005
4963	Putative cytochrome P450	SCO2884	0.0005
6254	Putative cytochrome P450	SCO6998	0.0005
358	Cystathionine beta-synthase	CBS	0.0004
693	Hemoglobin subunit beta	HBB	0.0004
6268	Hydroxyacid oxidase 1	HAO1	0.0004
810	Heme oxygenase 1	HMOX1	0.0004
3391	Heme oxygenase 1	pbsA1	0.0004
4509	Acetoin(diacetyl) reductase	budC	0.0004
3689	Endoglucanase A	celA	0.0004
3009	Beta-glucanase	Not Available	0.0004
5411	Slt-IIvB	stxB2e	0.0004
5565	Inorganic polyphosphate/ATP-glucomannokinase	ppgmk	0.0004
5563	Galectin-2	LGALS2	0.0004
1875	Pulmonary surfactant-associated protein D	SFTPD	0.0004
5569	Endo-1,4-beta glucanase EngF	engF	0.0004
5046	Ecotin	eco	0.0004
3793	Aspartate ammonia-lyase	aspA	0.0004
5554	D-galactose-binding periplasmic protein	mglB	0.0004
3741	D-galactose-binding periplasmic protein precursor	mglB	0.0004
5568	Endoglucanase C307	celC307	0.0004
5553	Endoglucanase E1	Acel_0614	0.0004
5562	Hexokinase	Not Available	0.0004
3744	Endoglucanase SS precursor	celS	0.0004
5570	Endoglucanase E-4	celD	0.0004
5559	Neopullulanase	nplT	0.0004
4670	Cellulase B	celB	0.0004
4668	Laminarinase	TM_0024	0.0004
4667	BH0236 protein	BH0236	0.0004
4671	Endoglucanase C	cenC	0.0004
2298	Cytochrome P450-cam	camC	0.0003
5176	YtnJ	moxC	0.0003
5416	Coat protein VP1	Not Available	0.0003
2705	Dimethyl sulfoxide reductase	dmsA	0.0003
5247	Endo-1,4-beta-xylanase	Not Available	0.0003
5248	Endo-1,4-beta-xylanase	xlnA	0.0003
5250	Endo-1,4-beta-xylanase	xyl	0.0003
4669	Endo-1,4-beta-xylanase A	xynA	0.0003
4715	Endo-1,4-beta-xylanase A	xlnA	0.0003
5560	Endo-1,4-beta-xylanase A	xynA	0.0003
1503	Galectin-7	LGALS7	0.0003
5498	Maltoporin	lamB	0.0003
5561	Maltoporin	lamB	0.0003
5056	Maltooligosyltrehalose trehalohydrolase, putative	treZ	0.0003
3525	ADP-ribose pyrophosphatase, mitochondrial	NUDT9	0.0003
4622	Amylase	Not Available	0.0003
2728	Glucan 1,4-alpha-maltotetraohydrolase	amyP	0.0003
2826	Glucose--fructose oxidoreductase	gfo	0.0003
1881	Hexokinase-1	HK1	0.0003
2324	Botulinum neurotoxin type B	botB	0.0003
3153	Quinoprotein glucose dehydrogenase-B	gdhB	0.0003
3747	Cellulase B precursor	celB	0.0003
3547	Enterotoxin type B	entB	0.0003
2856	Glucosamine-6-phosphate isomerase	GNPDA1	0.0003
2564	Glucan 1,4-alpha-maltohexaosidase	Not Available	0.0003
4819	Hydrolase	Not Available	0.0003
5249	Hydrolase	Not Available	0.0003
5436	Hydrolase	Not Available	0.0003
2531	Alpha-amylase	amyE	0.0003
2948	Alpha-amylase	amy	0.0003
3169	Alpha-amylase	Not Available	0.0003
2541	Neopullulanase 1	tvaI	0.0003
4811	Amylosucrase	ams	0.0003
3091	Maltodextrin phosphorylase	malP	0.0003
2606	Neopullulanase 2	tvaII	0.0003
4692	A/G-specific adenine glycosylase	mutY	0.0003
3225	Shiga toxin B-chain	stxB	0.0003
3365	Beta-amylase	spoII	0.0003
4830	Aldose 1-epimerase	galM	0.0003
6614	Lactase-like protein	LCTL	0.0003
1675	Glucokinase	GCK	0.0003
4662	Glucokinase	glk	0.0003
3030	Salivary alpha-amylase	AMY1A	0.0003
2293	Cyclomaltodextrin glucanotransferase	Not Available	0.0003
2508	Cyclomaltodextrin glucanotransferase	cgt	0.0003
2523	Cyclomaltodextrin glucanotransferase	cgt	0.0003
3207	Cyclomaltodextrin glucanotransferase	amyA	0.0003
4272	POSSIBLE CELLULASE CELA1	celA1	0.0003
2570	Tetanus toxin	tetX	0.0002
2448	Exoglucanase/xylanase [Includes: Exoglucanase	cex	0.0002
3668	Maltose-binding periplasmic protein precursor	malE	0.0002
2802	Endoglucanase G	celCCG	0.0002
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0002
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0002
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0002
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0002
2440	Endoglucanase F	celCCF	0.0002
2245	Xylose isomerase	xylA	0.0002
2253	Xylose isomerase	xylA	0.0002
2260	Xylose isomerase	xylA	0.0002
2431	Xylose isomerase	xylA	0.0002
2252	Endoglucanase 5A	cel5A	0.0002
10	Glycogen phosphorylase, liver form	PYGL	0.0002
2723	Cholera enterotoxin subunit B	ctxB	0.0002
4513	Pancreatic alpha-amylase	AMY2A	0.0002
2427	Ferrichrome-iron receptor	fhuA	0.0002
1152	Glycogen phosphorylase, muscle form	PYGM	0.0002

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB04552 - Niflumic Acid

Targets

Transporters

Predictions