DT-Web: DB00917

Identification

Name

Dinoprostone

Accession Number

DB00917 (APRD00927)

Type

small molecule

Description

Dinoprostone is a naturally occurring prostaglandin E2 (PGE2). It has important effects in labour. It also stimulates osteoblasts to release factors which stimualtes bone resorption by osteoclasts. As a prescription drug it is used as a vaginal suppository, to prepare the cervix for labour and to induce labour.

Structure

MOL SDF PDB SMILES InChI

Categories ^(*)

Molecular Weight

352.4651

Groups

approved

Monoisotopic Weight

352.224974134

Pharmacology

Indication

For the termination of pregnancy during the second trimester (from the 12th through the 20th gestational week as calculated from the first day of the last normal menstrual period), as well as for evacuation of the uterine contents in the management of missed abortion or intrauterine fetal death up to 28 weeks of gestational age as calculated from the first day of the last normal menstrual period. Also used in the management of nonmetastatic gestational trophoblastic disease (benign hydatidiform mole). Other indications include improving the cervical inducibility (cervical "ripening") in pregnant women at or near term with a medical or obstetrical need for labor induction, and the management of postpartum hemorrhage.

Mechanism of action

Dinoprostone administered intravaginally stimulates the myometrium of the gravid uterus to contract in a manner that is similar to the contractions seen in the term uterus during labor, resulting in the evacuation of the products of conception from the uterus. It is believed that dinoprostone exerts its uterine effects via direct myometrial stimulation, but the exact mechanism of action is unkown. Other suggested mechanisms include the regulation of cellular membrane calcium transport and of intracellular concentrations of cyclic 3',5'-adenosine monophosphate. Dinoprostone also appears to produce local cervical effects including softening, effacement, and dilation. The exact mechanism of action for this effect is also unknown, but it has been suggested that this effect may be associated with collagen degradation caused by secretion of the enzyme collagenase as a partial response to locally administered dinoprostone.

Absorption

Absorbed at a rate of 0.3 mg per hour over 12 hours while the vaginal system is in place.

Protein binding

73%, to albumin

Biotransformation

Rapid metabolism of dinoprostone occurs primarily in the local tissues; any systemic absorption of the medication is cleared mainly in the maternal lungs and, secondarily, at sites such as the liver and kidneys.

Route of elimination

The major route of elimination of the products of PGE2 metabolism is the kidneys.

Toxicity

Oral, mouse: LD₅₀ = 750 mg/kg; Oral, rat: LD₅₀ = 500 mg/kg.

Affected organisms

Humans and other mammals

Interactions

Drug Interactions

Drug

Mechanism of interaction

Carbetocin

Dinoprostone may enhance the therapeutic effect of carbetocin. Avoid concomitant use of carbetocin with dinoprostone. The oxytocic activity of carbetocin (oxytocin analogue) may be augmented by agents used to promote cervical ripening (eg, dinoprostone, misoprostol). Dinoprostone (vaginal insert) prescribing information recommends waiting at least 30 minute following its removal before initiating treatment with oxytocic agents. A similar approach might be anticipated with misoprostol use.

Food Interactions

Not Available

Prostaglandin E2 receptor, EP2 subtype
Name	Prostaglandin E2 receptor, EP2 subtype
Gene Name	PTGER2
Pharmacological action	yes
Actions	agonist
References	Baryawno N, Sveinbjornsson B, Eksborg S, Orrego A, Segerstrom L, Oqvist CO, Holm S, Gustavsson B, Kagedal B, Kogner P, Johnsen JI: Tumor-growthpromoting cyclooxygenase-2 prostaglandin E2 pathway provides medulloblastoma therapeutic targets. Neuro Oncol. 2008 Aug 20. - Pubmed Tamiji J, Crawford DA: Prostaglandin E(2) and misoprostol induce neurite retraction in Neuro-2a cells. Biochem Biophys Res Commun. 2010 Jul 30;398(3):450-6. Epub 2010 Jun 27. - Pubmed Legler DF, Bruckner M, Uetz-von Allmen E, Krause P: Prostaglandin E2 at new glance: novel insights in functional diversity offer therapeutic chances. Int J Biochem Cell Biol. 2010 Feb;42(2):198-201. Epub 2009 Sep 27. - Pubmed Sugimoto Y, Narumiya S: Prostaglandin E receptors. J Biol Chem. 2007 Apr 20;282(16):11613-7. Epub 2007 Feb 28. - Pubmed Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score	0.935
Prostaglandin E2 receptor, EP1 subtype
Name	Prostaglandin E2 receptor, EP1 subtype
Gene Name	PTGER1
Pharmacological action	yes
Actions	agonist
References	Baryawno N, Sveinbjornsson B, Eksborg S, Orrego A, Segerstrom L, Oqvist CO, Holm S, Gustavsson B, Kagedal B, Kogner P, Johnsen JI: Tumor-growthpromoting cyclooxygenase-2 prostaglandin E2 pathway provides medulloblastoma therapeutic targets. Neuro Oncol. 2008 Aug 20. - Pubmed Tamiji J, Crawford DA: Prostaglandin E(2) and misoprostol induce neurite retraction in Neuro-2a cells. Biochem Biophys Res Commun. 2010 Jul 30;398(3):450-6. Epub 2010 Jun 27. - Pubmed Legler DF, Bruckner M, Uetz-von Allmen E, Krause P: Prostaglandin E2 at new glance: novel insights in functional diversity offer therapeutic chances. Int J Biochem Cell Biol. 2010 Feb;42(2):198-201. Epub 2009 Sep 27. - Pubmed Sugimoto Y, Narumiya S: Prostaglandin E receptors. J Biol Chem. 2007 Apr 20;282(16):11613-7. Epub 2007 Feb 28. - Pubmed
DTHybrid score	0.8029
Prostaglandin E2 receptor, EP3 subtype
Name	Prostaglandin E2 receptor, EP3 subtype
Gene Name	PTGER3
Pharmacological action	yes
Actions	agonist
References	Baryawno N, Sveinbjornsson B, Eksborg S, Orrego A, Segerstrom L, Oqvist CO, Holm S, Gustavsson B, Kagedal B, Kogner P, Johnsen JI: Tumor-growthpromoting cyclooxygenase-2 prostaglandin E2 pathway provides medulloblastoma therapeutic targets. Neuro Oncol. 2008 Aug 20. - Pubmed Tamiji J, Crawford DA: Prostaglandin E(2) and misoprostol induce neurite retraction in Neuro-2a cells. Biochem Biophys Res Commun. 2010 Jul 30;398(3):450-6. Epub 2010 Jun 27. - Pubmed Legler DF, Bruckner M, Uetz-von Allmen E, Krause P: Prostaglandin E2 at new glance: novel insights in functional diversity offer therapeutic chances. Int J Biochem Cell Biol. 2010 Feb;42(2):198-201. Epub 2009 Sep 27. - Pubmed Sugimoto Y, Narumiya S: Prostaglandin E receptors. J Biol Chem. 2007 Apr 20;282(16):11613-7. Epub 2007 Feb 28. - Pubmed
DTHybrid score	0.918
Prostaglandin E2 receptor EP4 subtype
Name	Prostaglandin E2 receptor EP4 subtype
Gene Name	PTGER4
Pharmacological action	yes
Actions	agonist
References	Wise H: Lack of interaction between prostaglandin E2 receptor subtypes in regulating adenylyl cyclase activity in cultured rat dorsal root ganglion cells. Eur J Pharmacol. 2006 Mar 27;535(1-3):69-77. Epub 2006 Mar 20. - Pubmed Baryawno N, Sveinbjornsson B, Eksborg S, Orrego A, Segerstrom L, Oqvist CO, Holm S, Gustavsson B, Kagedal B, Kogner P, Johnsen JI: Tumor-growthpromoting cyclooxygenase-2 prostaglandin E2 pathway provides medulloblastoma therapeutic targets. Neuro Oncol. 2008 Aug 20. - Pubmed Tamiji J, Crawford DA: Prostaglandin E(2) and misoprostol induce neurite retraction in Neuro-2a cells. Biochem Biophys Res Commun. 2010 Jul 30;398(3):450-6. Epub 2010 Jun 27. - Pubmed Legler DF, Bruckner M, Uetz-von Allmen E, Krause P: Prostaglandin E2 at new glance: novel insights in functional diversity offer therapeutic chances. Int J Biochem Cell Biol. 2010 Feb;42(2):198-201. Epub 2009 Sep 27. - Pubmed Sugimoto Y, Narumiya S: Prostaglandin E receptors. J Biol Chem. 2007 Apr 20;282(16):11613-7. Epub 2007 Feb 28. - Pubmed
DTHybrid score	0.8234

Cholesterol side-chain cleavage enzyme, mitochondrial
Name	Cholesterol side-chain cleavage enzyme, mitochondrial
Gene Name	CYP11A1
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.3243
Cytochrome P450 19A1
Name	Cytochrome P450 19A1
Gene Name	CYP19A1
Actions	inducer
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4526
Cytochrome P450 1A2
Name	Cytochrome P450 1A2
Gene Name	CYP1A2
Actions	substrate
References	Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score	0.4553

Solute carrier family 22 member 2
Name	Solute carrier family 22 member 2
Gene Name	SLC22A2
Actions	inhibitor
References	Kimura H, Takeda M, Narikawa S, Enomoto A, Ichida K, Endou H: Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8. - Pubmed
DTHybrid score	0.3602
Solute carrier family 22 member 1
Name	Solute carrier family 22 member 1
Gene Name	SLC22A1
Actions	inhibitor
References	Kimura H, Takeda M, Narikawa S, Enomoto A, Ichida K, Endou H: Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8. - Pubmed
DTHybrid score	0.4393
Multidrug resistance-associated protein 5
Name	Multidrug resistance-associated protein 5
Gene Name	ABCC5
Actions	inhibitor
References	Reid G, Wielinga P, Zelcer N, van der Heijden I, Kuil A, de Haas M, Wijnholds J, Borst P: The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9244-9. Epub 2003 Jun 30. - Pubmed
DTHybrid score	0.361
Solute carrier family 22 member 6
Name	Solute carrier family 22 member 6
Gene Name	SLC22A6
Actions	substrate,inhibitor
References	Kimura H, Takeda M, Narikawa S, Enomoto A, Ichida K, Endou H: Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8. - Pubmed Lu R, Chan BS, Schuster VL: Cloning of the human kidney PAH transporter: narrow substrate specificity and regulation by protein kinase C. Am J Physiol. 1999 Feb;276(2 Pt 2):F295-303. - Pubmed Sekine T, Watanabe N, Hosoyamada M, Kanai Y, Endou H: Expression cloning and characterization of a novel multispecific organic anion transporter. J Biol Chem. 1997 Jul 25;272(30):18526-9. - Pubmed
DTHybrid score	0.6994
Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Actions	substrate,inhibitor
References	Kimura H, Takeda M, Narikawa S, Enomoto A, Ichida K, Endou H: Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8. - Pubmed Ohtsuki S, Kikkawa T, Mori S, Hori S, Takanaga H, Otagiri M, Terasaki T: Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier. J Pharmacol Exp Ther. 2004 Jun;309(3):1273-81. Epub 2004 Feb 4. - Pubmed Kobayashi Y, Ohshiro N, Tsuchiya A, Kohyama N, Ohbayashi M, Yamamoto T: Renal transport of organic compounds mediated by mouse organic anion transporter 3 (mOat3): further substrate specificity of mOat3. Drug Metab Dispos. 2004 May;32(5):479-83. - Pubmed
DTHybrid score	0.7339
Solute carrier family 22 member 11
Name	Solute carrier family 22 member 11
Gene Name	SLC22A11
Actions	inhibitor
References	Kimura H, Takeda M, Narikawa S, Enomoto A, Ichida K, Endou H: Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8. - Pubmed
DTHybrid score	0.5004
Solute carrier family 22 member 7
Name	Solute carrier family 22 member 7
Gene Name	SLC22A7
Actions	substrate,inhibitor
References	Kimura H, Takeda M, Narikawa S, Enomoto A, Ichida K, Endou H: Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8. - Pubmed Kobayashi Y, Ohshiro N, Shibusawa A, Sasaki T, Tokuyama S, Sekine T, Endou H, Yamamoto T: Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice. Mol Pharmacol. 2002 Jul;62(1):7-14. - Pubmed Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H: Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett. 1998 Jun 12;429(2):179-82. - Pubmed Morita N, Kusuhara H, Sekine T, Endou H, Sugiyama Y: Functional characterization of rat organic anion transporter 2 in LLC-PK1 cells. J Pharmacol Exp Ther. 2001 Sep;298(3):1179-84. - Pubmed
DTHybrid score	0.4208
Multidrug resistance-associated protein 4
Name	Multidrug resistance-associated protein 4
Gene Name	ABCC4
Actions	substrate
References	Reid G, Wielinga P, Zelcer N, van der Heijden I, Kuil A, de Haas M, Wijnholds J, Borst P: The human multidrug resistance protein MRP4 functions as a prostaglandin efflux transporter and is inhibited by nonsteroidal antiinflammatory drugs. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9244-9. Epub 2003 Jun 30. - Pubmed
DTHybrid score	0.4909
Solute carrier organic anion transporter family member 2B1
Name	Solute carrier organic anion transporter family member 2B1
Gene Name	SLCO2B1
Actions	substrate
References	Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, Tsuji A: Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60. - Pubmed Nishio T, Adachi H, Nakagomi R, Tokui T, Sato E, Tanemoto M, Fujiwara K, Okabe M, Onogawa T, Suzuki T, Nakai D, Shiiba K, Suzuki M, Ohtani H, Kondo Y, Unno M, Ito S, Iinuma K, Nunoki K, Matsuno S, Abe T: Molecular identification of a rat novel organic anion transporter moat1, which transports prostaglandin D(2), leukotriene C(4), and taurocholate. Biochem Biophys Res Commun. 2000 Sep 7;275(3):831-8. - Pubmed
DTHybrid score	0.5894
Solute carrier organic anion transporter family member 1A2
Name	Solute carrier organic anion transporter family member 1A2
Gene Name	SLCO1A2
Actions	substrate
References	Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed Cattori V, van Montfoort JE, Stieger B, Landmann L, Meijer DK, Winterhalter KH, Meier PJ, Hagenbuch B: Localization of organic anion transporting polypeptide 4 (Oatp4) in rat liver and comparison of its substrate specificity with Oatp1, Oatp2 and Oatp3. Pflugers Arch. 2001 Nov;443(2):188-95. - Pubmed Kanai N, Lu R, Bao Y, Wolkoff AW, Schuster VL: Transient expression of oatp organic anion transporter in mammalian cells: identification of candidate substrates. Am J Physiol. 1996 Feb;270(2 Pt 2):F319-25. - Pubmed
DTHybrid score	0.5336
Organic solute transporter subunit alpha
Name	Organic solute transporter subunit alpha
Gene Name	OSTA
Actions	substrate
References	Seward DJ, Koh AS, Boyer JL, Ballatori N: Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003 Jul 25;278(30):27473-82. Epub 2003 Apr 28. - Pubmed
DTHybrid score	0.3182
Organic solute transporter subunit beta
Name	Organic solute transporter subunit beta
Gene Name	OSTB
Actions	substrate
References	Seward DJ, Koh AS, Boyer JL, Ballatori N: Functional complementation between a novel mammalian polygenic transport complex and an evolutionarily ancient organic solute transporter, OSTalpha-OSTbeta. J Biol Chem. 2003 Jul 25;278(30):27473-82. Epub 2003 Apr 28. - Pubmed
DTHybrid score	0.3184
Solute carrier organic anion transporter family member 2A1
Name	Solute carrier organic anion transporter family member 2A1
Gene Name	SLCO2A1
Actions	substrate
References	Lu R, Kanai N, Bao Y, Schuster VL: Cloning, in vitro expression, and tissue distribution of a human prostaglandin transporter cDNA(hPGT). J Clin Invest. 1996 Sep 1;98(5):1142-9. - Pubmed Kanai N, Lu R, Satriano JA, Bao Y, Wolkoff AW, Schuster VL: Identification and characterization of a prostaglandin transporter. Science. 1995 May 12;268(5212):866-9. - Pubmed
DTHybrid score	0.4989
Solute carrier organic anion transporter family member 4A1
Name	Solute carrier organic anion transporter family member 4A1
Gene Name	SLCO4A1
Actions	substrate
References	Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, Tsuji A: Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60. - Pubmed
DTHybrid score	0.3892
Solute carrier organic anion transporter family member 1C1
Name	Solute carrier organic anion transporter family member 1C1
Gene Name	SLCO1C1
Actions	substrate
References	Pizzagalli F, Hagenbuch B, Stieger B, Klenk U, Folkers G, Meier PJ: Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol. 2002 Oct;16(10):2283-96. - Pubmed
DTHybrid score	0.3919
Solute carrier organic anion transporter family member 3A1
Name	Solute carrier organic anion transporter family member 3A1
Gene Name	SLCO3A1
Actions	substrate
References	Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, Tsuji A: Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60. - Pubmed Adachi H, Suzuki T, Abe M, Asano N, Mizutamari H, Tanemoto M, Nishio T, Onogawa T, Toyohara T, Kasai S, Satoh F, Suzuki M, Tokui T, Unno M, Shimosegawa T, Matsuno S, Ito S, Abe T: Molecular characterization of human and rat organic anion transporter OATP-D. Am J Physiol Renal Physiol. 2003 Dec;285(6):F1188-97. - Pubmed
DTHybrid score	0.5006
Solute carrier organic anion transporter family member 1B1
Name	Solute carrier organic anion transporter family member 1B1
Gene Name	SLCO1B1
Actions	substrate
References	Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M, Tsuji A: Molecular identification and characterization of novel members of the human organic anion transporter (OATP) family. Biochem Biophys Res Commun. 2000 Jun 24;273(1):251-60. - Pubmed Abe T, Kakyo M, Tokui T, Nakagomi R, Nishio T, Nakai D, Nomura H, Unno M, Suzuki M, Naitoh T, Matsuno S, Yawo H: Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J Biol Chem. 1999 Jun 11;274(24):17159-63. - Pubmed Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F, Fattinger K, Meier PJ, Hagenbuch B: Organic anion-transporting polypeptide B (OATP-B) and its functional comparison with three other OATPs of human liver. Gastroenterology. 2001 Feb;120(2):525-33. - Pubmed
DTHybrid score	0.5312

Id	Partner name	Gene Name	Score
4512	Cytochrome P450 3A4	CYP3A4	0.4325
1588	Multidrug resistance protein 1	ABCB1	0.4118
6157	Solute carrier organic anion transporter family member 1B3	SLCO1B3	0.3045
4757	Cytochrome P450 2C9	CYP2C9	0.2873
587	Serum albumin	ALB	0.2579
6016	Cytochrome P450 2C19	CYP2C19	0.2522
1735	Canalicular multispecific organic anion transporter 1	ABCC2	0.2478
4924	Cytochrome P450 2C8	CYP2C8	0.2418
672	Prostaglandin F2-alpha receptor	PTGFR	0.2227
4119	Cytochrome P450 2D6	CYP2D6	0.2164
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.2114
862	Multidrug resistance-associated protein 1	ABCC1	0.1966
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.1909
6141	Sodium/bile acid cotransporter	SLC10A1	0.1725
776	Bile salt export pump	ABCB11	0.1721
1709	Canalicular multispecific organic anion transporter 2	ABCC3	0.1716
118	Organic cation/carnitine transporter 2	SLC22A5	0.1677
4118	Cytochrome P450 3A5	CYP3A5	0.1629
738	Monocarboxylate transporter 1	SLC16A1	0.1535
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.1468
6024	Cytochrome P450 1A1	CYP1A1	0.137
6107	Cytochrome P450 3A7	CYP3A7	0.1346
20	Prostaglandin G/H synthase 1	PTGS1	0.1333
6030	Cytochrome P450 2B6	CYP2B6	0.1257
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.1202
290	Prostaglandin G/H synthase 2	PTGS2	0.1176
833	Organic cation/carnitine transporter 1	SLC22A4	0.1149
6013	Cytochrome P450 2E1	CYP2E1	0.1107
6147	Solute carrier family 22 member 3	SLC22A3	0.1058
527	Prostacyclin receptor	PTGIR	0.1023
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.1016
136	Estrogen receptor	ESR1	0.0972
758	Thyroid hormone receptor alpha	THRA	0.0941
5718	Cytochrome P450 2A6	CYP2A6	0.0919
6148	Multidrug resistance-associated protein 7	ABCC10	0.0917
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0885
146	Androgen receptor	AR	0.0868
6149	Solute carrier family 22 member 10	SLC22A10	0.0851
6140	Ileal sodium/bile acid cotransporter	SLC10A2	0.0825
346	Thyroid hormone receptor beta-1	THRB	0.0796
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0783
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0777
3587	Gastrotropin	FABP6	0.0764
756	Sex hormone-binding globulin	SHBG	0.071
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0697
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.0659
594	Thyroxine-binding globulin	SERPINA7	0.0653
33	Cystine/glutamate transporter	SLC7A11	0.0652
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0636
1792	Tissue-type plasminogen activator	PLAT	0.0614
1898	Cytochrome P450 1B1	CYP1B1	0.06
563	Thyroid peroxidase	TPO	0.0536
52	Pyruvate kinase isozymes R/L	PKLR	0.0518
2922	Glycerol kinase	glpK	0.0504
373	Transthyretin	TTR	0.0503
6085	Fatty acid-binding protein, intestinal	FABP2	0.0501
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.0481
6020	Aldehyde oxidase	AOX1	0.0475
4109	cAMP-specific 3',5'-cyclic phosphodiesterase 4C	PDE4C	0.047
6106	Cytochrome P450 2C18	CYP2C18	0.0466
22	30S ribosomal protein S4	rpsD	0.0462
6714	30S ribosomal protein S4	rpsD	0.0462
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.0461
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.0461
3947	Xanthine dehydrogenase/oxidase	XDH	0.0449
5626	Nucleoside diphosphate kinase B	NME2	0.0436
140	30S ribosomal protein S9	rpsI	0.0435
6719	30S ribosomal protein S9	rpsI	0.0435
6725	30S ribosomal protein S9	rpsI	0.0435
6151	Monocarboxylate transporter 10	SLC16A10	0.0434
599	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.0425
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0425
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0425
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0425
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0424
489	Monocarboxylate transporter 2	SLC16A7	0.0423
3810	Catechol O-methyltransferase	COMT	0.042
1181	Alpha-1-acid glycoprotein 1	ORM1	0.0417
199	Monocarboxylate transporter 8	SLC16A2	0.0409
275	Arachidonate 5-lipoxygenase	ALOX5	0.0406
2597	Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]	glmS	0.0403
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.04
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0396
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.0392
6137	Multidrug resistance-associated protein 6	ABCC6	0.0386
2206	Glucose-6-phosphate isomerase	GPI	0.0381
3736	Glyceraldehyde-3-phosphate dehydrogenase A	gapA	0.0376
2358	cAMP-specific 3',5'-cyclic phosphodiesterase 4D	PDE4D	0.0376
4628	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase	gapN	0.0375
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.037
492	Histamine H1 receptor	HRH1	0.0362
338	DNA polymerase	UL30	0.0358
379	DNA polymerase	UL54	0.0358
697	DNA polymerase	ORF28	0.0358
2482	DNA polymerase	43	0.0358
4104	DNA polymerase	BALF5	0.0358
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0354
5294	Nucleoside diphosphate kinase A	NME1	0.0348
3941	Amine oxidase [flavin-containing] A	MAOA	0.0343
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0332
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0331
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0329
380	Cytochrome P450 17A1	CYP17A1	0.0328
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0328
260	Cytochrome P450 51	ERG11	0.0327
761	Cytochrome P450 51	ERG11	0.0327
3163	Cytochrome P450 51	cyp51	0.0327
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.0327
556	Alpha-1A adrenergic receptor	ADRA1A	0.0325
404	DNA gyrase subunit A	gyrA	0.032
6224	DNA gyrase subunit A	gyrA	0.032
3685	Catabolite gene activator	crp	0.0319
4655	Adenylate cyclase	cyaC	0.0318
4759	Adenylate cyclase	cyaB2	0.0318
24	Thymidylate synthase	TMP1	0.0318
359	Thymidylate synthase	TYMS	0.0318
2626	Thymidylate synthase	thyA	0.0318
2729	Thymidylate synthase	thyA	0.0318
5352	Thymidylate synthase	THYA	0.0318
5650	NimA-related protein	DR_0842	0.0316
3923	Cholinesterase	BCHE	0.0307
500	Monocarboxylate transporter 4	SLC16A3	0.0304
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0303
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0303
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0302
633	Penicillin-binding proteins 1A/1B	pbpA	0.0301
558	Solute carrier family 12 member 1	SLC12A1	0.0301
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0298
318	Alpha-2A adrenergic receptor	ADRA2A	0.0297
468	Cytochrome P450 4A11	CYP4A11	0.0296
645	Penicillin-binding protein 1A	mrcA	0.0295
5805	Penicillin-binding protein 1A	ponA	0.0295
6185	Penicillin-binding protein 1A	mrcA	0.0295
6799	Penicillin-binding protein 1A	pbpA	0.0295
869	Estrogen receptor beta	ESR2	0.0293
124	Histamine H2 receptor	HRH2	0.0292
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.029
766	Beta-2 adrenergic receptor	ADRB2	0.0283
6031	Cytochrome P450 3A43	CYP3A43	0.0283
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0282
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0282
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0279
543	Penicillin-binding protein 1B	mrcB	0.0274
6186	Penicillin-binding protein 1B	ponB	0.0274
6822	Penicillin-binding protein 1b	pbp1b	0.0274
6844	Penicillin-binding protein 1b	pbp1b	0.0274
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0274
831	D(2) dopamine receptor	DRD2	0.0274
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.0273
4760	Mll3241 protein	mll3241	0.0271
5353	Glutamate decarboxylase alpha	gadA	0.027
1405	Thiopurine S-methyltransferase	TPMT	0.0269
193	Beta-1 adrenergic receptor	ADRB1	0.0266
3957	Adenosine deaminase	ADA	0.0266
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0265
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0259
36	Insulin receptor	INSR	0.0258
3254	Bifunctional protein putA [Includes: Proline dehydrogenase	putA	0.0254
293	Gamma-glutamyl hydrolase	GGH	0.0251
438	Taste receptor type 1 member 2	TAS1R2	0.0248
4604	Liver carboxylesterase 1	CES1	0.0248
477	DNA topoisomerase 4 subunit A	parC	0.0247
886	DNA topoisomerase 4 subunit A	parC	0.0247
6226	DNA topoisomerase 4 subunit A	parC	0.0247
731	HIV-1 protease	HIV-1 protease	0.0247
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0243
629	Alpha-2B adrenergic receptor	ADRA2B	0.0243
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0239
6033	High affinity interleukin-8 receptor A	CXCR1	0.0237
6171	Solute carrier family 28 member 3	SLC28A3	0.0237
357	Carbonic anhydrase 2	CA2	0.0236
4217	Telomerase reverse transcriptase	TERT	0.0229
6218	Pannexin-1	PANX1	0.0229
23	D(1A) dopamine receptor	DRD1	0.0228
3939	Amine oxidase [flavin-containing] B	MAOB	0.0223
2320	Thymidine kinase, cytosolic	TK1	0.0222
3686	Acyl-CoA thioesterase I precursor	tesA	0.0222
1650	Heme carrier protein 1	SLC46A1	0.022
2853	14 kDa fatty acid-binding protein	Not Available	0.0219
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0218
5818	Folate receptor alpha	FOLR1	0.0217
3676	Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive	aroG	0.0216
904	Glutathione S-transferase P	GSTP1	0.0216
3134	Phospho-2-dehydro-3-deoxyheptonate aldolase	aroF	0.0215
871	Glucocorticoid receptor	NR3C1	0.0212
244	Angiotensin-converting enzyme	ACE	0.0212
4773	Deoxycytidine kinase	DCK	0.0211
1867	Major prion protein	PRNP	0.0208
378	Alpha-2C adrenergic receptor	ADRA2C	0.0207
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0205
3639	Thymidine phosphorylase	deoA	0.0203
3936	Thymidine phosphorylase	TYMP	0.0203
887	DNA gyrase subunit B	gyrB	0.0201
4150	DNA gyrase subunit B	gyrB	0.0201
6225	DNA gyrase subunit B	gyrB	0.0201
4116	Dihydropteroate synthetase	Not Available	0.0199
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0199
4384	Capsule biosynthesis protein	synC	0.0199
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0197
2016	Dipeptidase 1	DPEP1	0.0197
632	Alpha-1B adrenergic receptor	ADRA1B	0.0196
115	Penicillin-binding protein 2	mrdA	0.0196
6069	Penicillin-binding protein 2	mrdA	0.0196
6118	Penicillin-binding protein 2	penA	0.0196
6187	Penicillin-binding protein 2	pbpA	0.0196
6686	Penicillin-binding protein 2	pbp2	0.0196
6939	Penicillin-binding protein 2	mrdA	0.0196
7163	Penicillin-binding protein 2	pbpA	0.0196
226	Gonadotropin-releasing hormone receptor	GNRHR	0.0193
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0193
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0192
1116	Phosphoenolpyruvate carboxykinase, cytosolic [GTP]	PCK1	0.0188
1757	Myeloperoxidase	MPO	0.0187
6044	Serum paraoxonase/lactonase 3	PON3	0.0185
474	Acetylcholinesterase	ACHE	0.0184
824	Sodium-dependent serotonin transporter	SLC6A4	0.0183
1	Peptidoglycan synthetase ftsI	ftsI	0.0183
4155	Peptidoglycan synthetase ftsI	ftsI	0.0183
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0182
634	Squalene monooxygenase	SQLE	0.0181
7196	Squalene monooxygenase	ERG1	0.0181
6207	30S ribosomal protein S14	rpsN	0.0179
6209	30S ribosomal protein S19	rpsS	0.0179
6712	30S ribosomal protein S19	rpsS	0.0179
6726	30S ribosomal protein S19	rpsS	0.0179
817	DNA topoisomerase 2-alpha	TOP2A	0.0179
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0179
6014	Cytochrome P450 2A13	CYP2A13	0.0178
1178	Adenosine A2a receptor	ADORA2A	0.0176
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0176
148	Lutropin-choriogonadotropic hormone receptor	LHCGR	0.0175
273	Apoptosis regulator Bcl-2	BCL2	0.0171
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.017
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.017
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0169
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.0169
2249	Aspartate aminotransferase	aspC	0.0167
2671	Aspartate aminotransferase	aspC	0.0167
5490	Aspartate aminotransferase	Not Available	0.0167
7	Nitric oxide synthase, inducible	NOS2	0.0166
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0164
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0163
2310	2-dehydro-3-deoxyphosphooctonate aldolase	kdsA	0.0163
2542	2-dehydro-3-deoxyphosphooctonate aldolase	kdsA	0.0163
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0161
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.0159
332	Beta-lactamase	blaZ	0.0159
2478	Beta-lactamase	ampC	0.0159
2613	Beta-lactamase	ampC	0.0159
2635	Beta-lactamase	ampC	0.0159
2700	Beta-lactamase	penP	0.0159
5445	Beta-lactamase	blaB	0.0159
6019	Beta-lactamase	SHV-7	0.0159
6701	Beta-lactamase	cphA	0.0159
6010	Thiamine transporter 1	SLC19A2	0.0159
592	Carbonic anhydrase 4	CA4	0.0159
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0157
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0157
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0156
53	Solute carrier family 12 member 5	SLC12A5	0.0156
663	Solute carrier family 12 member 4	SLC12A4	0.0156
6220	Aryl hydrocarbon receptor	AHR	0.0155
789	Alpha-1D adrenergic receptor	ADRA1D	0.0154
295	Carbonic anhydrase 1	CA1	0.0153
4122	Histone deacetylase 2	HDAC2	0.0153
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0152
2183	Fatty acid-binding protein, adipocyte	FABP4	0.015
2261	Major NAD(P)H-flavin oxidoreductase	Not Available	0.0149
1198	Serum paraoxonase/arylesterase 1	PON1	0.0149
6223	Penicillin-binding protein 1C	pbpC	0.0149
310	Solute carrier family 12 member 2	SLC12A2	0.0145
16	Adenosine A1 receptor	ADORA1	0.0145
6012	Tryptophan 2,3-dioxygenase	TDO2	0.0145
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0144
4226	Uridine phosphorylase 2	UPP2	0.0144
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0143
70	Type-1 angiotensin II receptor	AGTR1	0.0142
175	Thiamin pyrophosphokinase 1	TPK1	0.0142
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0141
867	Penicillin-binding protein 3	pbpC	0.014
6119	Penicillin-binding protein 3	pbp3	0.014
7154	Penicillin-binding protein 3	pbp3	0.014
7157	Penicillin-binding protein 3	LMHCC_2184	0.014
7162	Penicillin-binding protein 3	pbpB	0.014
7172	Penicillin-binding protein 3	pbp3	0.014
2981	Phospholipase A2, membrane associated	PLA2G2A	0.0138
1654	Interleukin-1 beta	IL1B	0.0137
281	5'-AMP-activated protein kinase subunit beta-1	PRKAB1	0.0137
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0134
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0131
2021	Thrombomodulin	THBD	0.0131
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.013
1141	Sialidase-1	NEU1	0.0129
64	Neuraminidase	NA	0.0129
641	Neuraminidase	NA	0.0129
2676	Neuraminidase	NA	0.0129
3026	Neuraminidase	NA	0.0129
3519	Neuraminidase	NA	0.0129
6007	Neuraminidase	NA	0.0129
713	Sodium-dependent dopamine transporter	SLC6A3	0.0129
4225	Uridine phosphorylase 1	UPP1	0.0128
26	Vascular endothelial growth factor receptor 3	FLT4	0.0128
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.0126
130	Prostacyclin synthase	PTGIS	0.0124
413	Amidophosphoribosyltransferase	PPAT	0.0123
2515	Amidophosphoribosyltransferase	purF	0.0123
3714	Amidophosphoribosyltransferase	purF	0.0123
308	30S ribosomal protein S12	rpsL	0.0122
6704	30S ribosomal protein S12	rpsL	0.0122
32	Vascular endothelial growth factor receptor 1	FLT1	0.0122
1010	Cytochrome P450 51A1	CYP51A1	0.0122
365	Dihydrofolate reductase	DHFR	0.0121
2381	Dihydrofolate reductase	DFR1	0.0121
2833	Dihydrofolate reductase	Not Available	0.0121
2931	Dihydrofolate reductase	folA	0.0121
3544	Dihydrofolate reductase	folA	0.0121
3682	Dihydrofolate reductase	folA	0.0121
6642	Dihydrofolate reductase	folA	0.0121
6756	Dihydrofolate reductase	dfrA	0.0121
908	Glutathione S-transferase theta-1	GSTT1	0.012
614	Progesterone receptor	PGR	0.0119
723	Cytosolic phospholipase A2	PLA2G4A	0.0119
4094	Gamma-aminobutyric acid type B receptor, subunit 2	GABBR2	0.0119
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0119
2472	Voltage-gated potassium channel	kcsA	0.0118
6366	Voltage-gated potassium channel	kcsA	0.0118
6043	Putative G-protein coupled receptor 44	GPR44	0.0117
465	Calmodulin	CALM1	0.0117
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0117
284	DNA-directed RNA polymerase beta chain	rpoB	0.0116
5773	DNA-directed RNA polymerase beta chain	rpoB	0.0116
4209	ATP-sensitive inward rectifier potassium channel 8	KCNJ8	0.0116
183	Vascular endothelial growth factor A	VEGFA	0.0115
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0115
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0115
5934	Cytochrome P450 26A1	CYP26A1	0.0113
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0113
6070	Nischarin	NISCH	0.0113
65	Matrix metalloproteinase-9	Not Available	0.0112
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0112
1244	Low-density lipoprotein receptor-related protein 2	LRP2	0.0111
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0111
494	Caspase-1	CASP1	0.0111
3809	Estrogen-related receptor gamma	ESRRG	0.011
1517	Beta-3 adrenergic receptor	ADRB3	0.011
4790	Glycosyltransferase GtfA	gtfA	0.011
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.011
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0108
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.0107
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0107
5880	Thrombopoietin receptor	MPL	0.0106
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0106
847	Mu-type opioid receptor	OPRM1	0.0106
1507	Cytochrome c	CYCS	0.0105
590	5-hydroxytryptamine 2C receptor	HTR2C	0.0104
3426	Glutamine synthetase	glnA	0.0104
3987	Glutamine synthetase	GLUL	0.0104
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0103
6126	Carbonic anhydrase 7	CA7	0.0103
737	Mineralocorticoid receptor	NR3C2	0.0102
5482	Sialidase-2	NEU2	0.0101
896	Glutathione S-transferase Mu 1	GSTM1	0.0101
638	D(3) dopamine receptor	DRD3	0.01
952	Dipeptidyl peptidase 4	DPP4	0.01
3760	Penicillin-binding protein 5 precursor	dacA	0.01
469	Annexin A1	ANXA1	0.01
504	Mast/stem cell growth factor receptor	KIT	0.01
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0099
1313	Lactoylglutathione lyase	GLO1	0.0098
407	Vascular endothelial growth factor receptor 2	KDR	0.0098
6146	High affinity copper uptake protein 1	SLC31A1	0.0098
4238	50S ribosomal protein L4	rplD	0.0098
5578	50S ribosomal protein L4	rplD	0.0098
6173	50S ribosomal protein L4	rplD	0.0098
6219	50S ribosomal protein L4	rplD	0.0098
958	Insulin-like growth factor 1 receptor	IGF1R	0.0097
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0097
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0097
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.0096
6165	Copper-transporting ATPase 1	ATP7A	0.0095
6163	Copper-transporting ATPase 2	ATP7B	0.0095
6164	POU domain, class 5, transcription factor 1	POU5F1	0.0095
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0095
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.0094
571	Melatonin receptor type 1A	MTNR1A	0.0094
362	Melatonin receptor type 1B	MTNR1B	0.0094
1830	5'-nucleotidase	NT5E	0.0094
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0093
6042	Prostaglandin reductase 2	PTGR2	0.0093
2077	Caspase-3	CASP3	0.0093
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0092
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.0092
5126	Arginase	rocF	0.0092
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0092
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0092
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0092
432	D(4) dopamine receptor	DRD4	0.009
819	Penicillin-binding protein 4	dacB	0.009
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.009
4237	50S ribosomal protein L22	rplV	0.009
1648	Elastin	ELN	0.0089
218	Monocarboxylate transporter 5	SLC16A4	0.0088
195	Monocarboxylate transporter 7	SLC16A6	0.0088
397	Monocarboxylate transporter 3	SLC16A8	0.0088
429	Monocarboxylate transporter 6	SLC16A5	0.0088
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.0088
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0086
694	Matrix protein 2	M	0.0086
1656	CYP2B protein	CYP2B	0.0085
6078	Neuronal acetylcholine receptor subunit beta-4	CHRNB4	0.0085
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0085
606	Cytochrome P450 27, mitochondrial	CYP27A1	0.0084
581	Cytochrome P450 2R1	CYP2R1	0.0084
6079	Neuronal acetylcholine receptor subunit alpha-3	CHRNA3	0.0084
818	50S ribosomal protein L10	rplJ	0.0083
4203	Histamine N-methyltransferase	HNMT	0.0083
740	Argininosuccinate synthase	ASS1	0.0083
865	Argininosuccinate synthase	ASS1	0.0083
2680	Argininosuccinate synthase	argG	0.0083
3194	Argininosuccinate synthase	argG	0.0083
277	Purine nucleoside phosphorylase	PNP	0.0082
2870	Purine nucleoside phosphorylase	punA	0.0082
2945	Purine nucleoside phosphorylase	punA	0.0082
4659	Purine nucleoside phosphorylase	TM_1596	0.0082
4825	Purine nucleoside phosphorylase	TTHA1435	0.0082
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0081
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0081
213	Amiloride-sensitive sodium channel subunit alpha	SCNN1A	0.0081
550	Amiloride-sensitive sodium channel subunit delta	SCNN1D	0.0081
27	Amiloride-sensitive sodium channel subunit beta	SCNN1B	0.0081
552	Amiloride-sensitive sodium channel subunit gamma	SCNN1G	0.0081
163	D(1B) dopamine receptor	DRD5	0.0081
828	Phenylalanine-4-hydroxylase	PAH	0.008
3109	Phenylalanine-4-hydroxylase	phhA	0.008
596	3-oxo-5-alpha-steroid 4-dehydrogenase 1	SRD5A1	0.0078
860	Nicotinamide N-methyltransferase	NNMT	0.0078
583	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	QPRT	0.0078
2442	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0078
2459	Nicotinate-nucleotide pyrophosphorylase [carboxylating]	nadC	0.0078
699	Nicotinic acid receptor 1	GPR109A	0.0078
928	Nicotinic acid receptor 2	GPR109B	0.0078
1680	Solute carrier family 2, facilitated glucose transporter member 1	SLC2A1	0.0078
1992	Vitamin D-binding protein	GC	0.0078
751	Potassium channel subfamily K member 6	KCNK6	0.0078
29	Tubulin beta-1 chain	TUBB1	0.0077
976	Platelet glycoprotein IX	GP9	0.0077
3704	Spermidine/putrescine-binding periplasmic protein precursor	potD	0.0077
702	UMP-CMP kinase	CMPK1	0.0076
771	Pyruvate carboxylase, mitochondrial	PC	0.0076
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0075
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0075
6182	Cytochrome P450 2J2	CYP2J2	0.0075
84	Nuclear receptor 0B1	NR0B1	0.0075
125	DNA polymerase beta	POLB	0.0074
2391	Ferrochelatase	hemH	0.0074
6502	Ferrochelatase	DKFZp686P18130	0.0074
1591	Ferrochelatase, mitochondrial	FECH	0.0074
131	Synaptic vesicular amine transporter	SLC18A2	0.0074
98	Pyruvate kinase isozymes M1/M2	PKM2	0.0074
624	Guanidinoacetate N-methyltransferase	GAMT	0.0073
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0073
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0073
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0072
172	Potassium channel subfamily K member 1	KCNK1	0.0071
3806	cGMP-dependent 3',5'-cyclic phosphodiesterase	PDE2A	0.0071
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0071
718	Folate receptor gamma	FOLR3	0.0071
299	Folate receptor beta	FOLR2	0.0071
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0071
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.007
401	Glutamate [NMDA] receptor subunit zeta-1	GRIN1	0.0068
1064	DNA (cytosine-5)-methyltransferase 1	DNMT1	0.0068
3014	Ribonuclease UK114	HRSP12	0.0068
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0067
3718	Hydrogen peroxide-inducible genes activator	oxyR	0.0067
5428	Replication protein	repA	0.0067
3617	Non-heme chloroperoxidase	cpo	0.0067
5426	Non-heme chloroperoxidase	cpo	0.0067
5427	Hydroxyquinol 1,2-dioxygenase	chqB	0.0067
714	Glutathione reductase, mitochondrial	GSR	0.0067
3018	HTH-type transcriptional regulator malT	malT	0.0067
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0067
3560	Gentamicin 3'-acetyltransferase	aacC1	0.0067
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0067
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0067
467	Delta-type opioid receptor	OPRD1	0.0066
114	Alanine--glyoxylate aminotransferase 2, mitochondrial	AGXT2	0.0066
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0066
749	Amiloride-sensitive cation channel 1, neuronal	ACCN1	0.0066
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.0065
3611	Cytidine deaminase	cdd	0.0065
3707	Cytidine deaminase	cdd	0.0065
4211	Cytidine deaminase	CDA	0.0065
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0064
6495	Cytochrome c oxidase subunit 7C, mitochondrial	COX7C	0.0064
6496	Cytochrome c oxidase subunit 8A, mitochondrial	COX8A	0.0064
6497	Cytochrome c oxidase subunit 6A2, mitochondrial	COX6A2	0.0064
6493	Cytochrome c oxidase subunit 6C	COX6C	0.0064
6499	Cytochrome c oxidase polypeptide 7A1, mitochondrial	COX7A1	0.0064
6494	Cytochrome c oxidase subunit 7B, mitochondrial	COX7B	0.0064
6498	Cytochrome c oxidase subunit 6B1	COX6B1	0.0064
6491	Cytochrome c oxidase subunit 5A, mitochondrial	COX5A	0.0064
6489	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial	COX4I1	0.0064
6490	Cytochrome c oxidase subunit 3	MT-CO3	0.0064
5793	Cytochrome c oxidase subunit 2	MT-CO2	0.0064
6559	Cytochrome c oxidase subunit 2	ctaC	0.0064
6669	Cytochrome c oxidase subunit 2	ctaC	0.0064
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0064
371	Cytochrome c oxidase subunit 1	MT-CO1	0.0064
6558	Cytochrome c oxidase subunit 1	ctaD	0.0064
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.0064
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.0064
459	Retinoic acid receptor RXR-alpha	RXRA	0.0064
3830	Calreticulin	CALR	0.0064
6131	Carbonic anhydrase 14	CA14	0.0062
1649	Small inducible cytokine A2	CCL2	0.0062
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0062
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0061
164	Histamine H4 receptor	HRH4	0.0061
3932	Glutathione S-transferase A2	GSTA2	0.006
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.006
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.006
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.006
117	Sterol O-acyltransferase 1	SOAT1	0.006
1341	Histamine H3 receptor	HRH3	0.006
509	Thymidine kinase	TK	0.006
570	Thymidine kinase	TK	0.006
2559	Thymidine kinase	TK	0.006
3430	Thymidine kinase	tdk	0.006
3518	Thymidine kinase	TK	0.006
5301	Thymidine kinase	tdk	0.006
5771	Thymidine kinase	ORF36	0.006
7009	Thymidine kinase	ORF36	0.006
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0059
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0059
387	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0059
7187	Amiloride-sensitive amine oxidase [copper-containing]	ABP1	0.0059
6034	Hydroxyindole O-methyltransferase	ASMT	0.0059
6035	Nuclear receptor ROR-beta	RORB	0.0059
6036	Eosinophil peroxidase	EPX	0.0059
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0059
2540	Choloylglycine hydrolase	cbh	0.0059
5682	Ribonuclease pancreatic	RNASE1	0.0059
2958	Probable tautomerase ydcE	pptA	0.0058
2573	Cocaine esterase	cocE	0.0058
7263	Cocaine esterase	Not Available	0.0058
6111	DNA polymerase epsilon subunit 4	POLE4	0.0058
827	Sodium/hydrogen exchanger 1	SLC9A1	0.0058
6112	DNA polymerase epsilon subunit 3	POLE3	0.0058
6122	Carbonic anhydrase 3	CA3	0.0058
6108	Ribonucleoside-diphosphate reductase subunit M2 B	RRM2B	0.0058
856	Vitamin D3 receptor	VDR	0.0058
6110	DNA polymerase epsilon subunit 2	POLE2	0.0058
6109	DNA polymerase epsilon catalytic subunit A	POLE	0.0058
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0058
3115	Ras-related protein Rab-9	RAB9A	0.0057
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0057
3603	Chlorocatechol 1,2-dioxygenase	clcA	0.0057
5924	Microtubule-associated protein 4	MAP4	0.0056
5923	Microtubule-associated protein tau	MAPT	0.0056
436	5-hydroxytryptamine 2B receptor	HTR2B	0.0056
6432	Transporter	snf	0.0056
6501	Fatty acid-binding protein, liver	FABP1	0.0055
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0055
3007	Carbonic anhydrase 12	CA12	0.0055
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0055
4205	Carbonic anhydrase 9	CA9	0.0055
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0055
1770	Phospholipase C	PLCL1	0.0055
2841	Phospholipase C	plc	0.0055
466	Solute carrier family 12 member 3	SLC12A3	0.0055
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0055
165	FL cytokine receptor	FLT3	0.0054
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0054
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0054
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0054
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.0054
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.0053
1852	Microtubule-associated protein 2	MAP2	0.0052
780	Retinoic acid receptor RXR-gamma	RXRG	0.0052
2300	Lysozyme	E	0.0052
3633	Lysozyme	R	0.0052
5597	Lysozyme	17	0.0052
229	Retinoic acid receptor beta	RARB	0.0052
730	Retinoic acid receptor alpha	RARA	0.0051
765	Indoleamine 2,3-dioxygenase	IDO1	0.0051
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0051
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0051
253	Sodium/potassium-transporting ATPase gamma chain	FXYD2	0.0051
1039	Histone deacetylase 9	HDAC9	0.005
696	Kappa-type opioid receptor	OPRK1	0.005
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.005
4218	Ribonucleoside-diphosphate reductase M2 subunit	RRM2	0.005
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0049
144	Hemoglobin subunit alpha	HBA1	0.0049
1630	Integrin beta-2	ITGB2	0.0049
88	Retinoic acid receptor RXR-beta	RXRB	0.0048
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0047
6168	Solute carrier family 22 member 16	SLC22A16	0.0047
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0047
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0047
162	Retinoic acid receptor gamma-1	RARG	0.0047
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0047
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0047
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0046
551	Carnitine O-acetyltransferase	CRAT	0.0046
6500	Phospholipase A2	PLA2G1B	0.0046
517	Alcohol dehydrogenase 1C	ADH1C	0.0046
303	Diamine acetyltransferase 2	SAT2	0.0045
623	Spermine oxidase	SMOX	0.0045
1317	Spermine synthase	SMS	0.0045
2693	Heat-labile enterotoxin B chain	eltB	0.0044
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0044
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0044
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0044
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0044
777	Tumor necrosis factor	TNF	0.0044
603	DNA polymerase alpha catalytic subunit	POLA1	0.0043
6645	D-amino-acid oxidase	DAO	0.0043
3755	Nucleoside-specific channel-forming protein tsx precursor	tsx	0.0043
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0043
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0043
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0043
5698	Riboflavin synthase alpha chain	ribE	0.0043
6837	Serine/threonine-protein kinase 17B	STK17B	0.0042
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0042
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0041
408	Riboflavin kinase	RFK	0.0041
844	Epidermal growth factor receptor	EGFR	0.0041
3478	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0041
4277	Glucose-1-phosphate thymidylyltransferase	rmlA	0.0041
267	Plasminogen activator inhibitor 1	SERPINE1	0.004
123	Diamine acetyltransferase 1	SAT1	0.004
921	Glutamate receptor 2	GRIA2	0.004
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.004
4034	Glutaredoxin-1	GLRX	0.004
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.004
4037	Hypothetical protein	GPX1	0.004
4297	Hypothetical protein	SP_1951	0.004
4521	Hypothetical protein	BC_2969	0.004
4540	Hypothetical protein	TM_1070	0.004
4555	Hypothetical protein	MT1739	0.004
4569	Hypothetical protein	mshD	0.004
4578	Hypothetical protein	PA3270	0.004
4747	Hypothetical protein	PA3967	0.004
5177	Hypothetical protein	TM_0096	0.004
5194	Hypothetical protein	PA1204	0.004
5240	Hypothetical protein	Rv2991	0.004
5370	Hypothetical protein	TM_1158	0.004
5710	Hypothetical protein	Tb927.5.1360	0.004
1928	Leukotriene C4 synthase	LTC4S	0.004
4029	Microsomal glutathione S-transferase 3	MGST3	0.004
4032	Microsomal glutathione S-transferase 1	MGST1	0.004
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.004
4035	Glutathione S-transferase Mu 5	GSTM5	0.004
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.004
4040	Glutathione peroxidase 7	GPX7	0.004
910	Epididymal secretory glutathione peroxidase	GPX5	0.004
4036	Glutathione peroxidase 6	GPX6	0.004
903	Glutathione S-transferase A5	GSTA5	0.004
911	Glutathione peroxidase 3	GPX3	0.004
906	Glutathione peroxidase 1	GPX1	0.004
900	Glutathione S-transferase A4	GSTA4	0.004
4038	Glutathione peroxidase 4	GPX4	0.004
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.004
4042	Glutathione transferase omega-2	GSTO2	0.004
907	Glutathione peroxidase 2	GPX2	0.004
4033	S-formylglutathione hydrolase	ESD	0.004
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.004
232	Corticosteroid-binding globulin	SERPINA6	0.004
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0039
1864	RET proto-oncogene	RET	0.0039
6124	Carbonic anhydrase 5B, mitochondrial	CA5B	0.0039
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0039
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0039
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0039
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0039
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0038
605	Fumarate reductase flavoprotein subunit	frdA	0.0038
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0038
3673	Fumarate reductase flavoprotein subunit	fccA	0.0038
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0038
6549	Fumarate reductase flavoprotein subunit	frdA	0.0038
1192	Sulfotransferase 1A1	SULT1A1	0.0038
6221	Steroid hormone receptor ERR1	ESRRA	0.0037
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0037
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0037
2782	Complement C1s subcomponent	C1S	0.0037
153	Dopamine beta-hydroxylase	DBH	0.0037
5878	Alpha-7 nicotinic cholinergic receptor subunit	CHRFAM7A	0.0037
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0037
572	Integrin alpha-L	ITGAL	0.0037
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0037
1629	Transcription factor AP-1	JUN	0.0036
3929	Phosphoethanolamine/phosphocholine phosphatase	PHOSPHO1	0.0036
3926	Choline transporter-like protein 2	SLC44A2	0.0036
3933	Choline/ethanolaminephosphotransferase	CEPT1	0.0036
1686	Choline transporter-like protein 1	SLC44A1	0.0036
3927	Choline transporter-like protein 3	SLC44A3	0.0036
861	Choline kinase alpha	CHKA	0.0036
549	Choline-phosphate cytidylyltransferase B	PCYT1B	0.0036
3925	Choline transporter-like protein 4	SLC44A4	0.0036
264	Choline/ethanolamine kinase [Includes: Choline kinase beta	CHKB	0.0036
769	High-affinity choline transporter 1	SLC5A7	0.0036
700	Choline dehydrogenase, mitochondrial	CHDH	0.0036
576	Choline O-acetyltransferase	CHAT	0.0036
3922	Phospholipase D2	PLD2	0.0036
3924	Phospholipase D1	PLD1	0.0036
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0036
268	Adenosine A2b receptor	ADORA2B	0.0036
2449	Tubulin alpha-3 chain	TUBA1A	0.0036
1074	Urokinase-type plasminogen activator	PLAU	0.0036
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0036
897	Glutathione S-transferase kappa 1	GSTK1	0.0035
898	Glutathione S-transferase A3	GSTA3	0.0035
2539	Tubulin alpha-1 chain	TUBA4A	0.0035
997	Protein kinase C beta type	PRKCB	0.0035
1618	High affinity nerve growth factor receptor	NTRK1	0.0035
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0035
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0035
909	Maleylacetoacetate isomerase	GSTZ1	0.0035
5998	Toll-like receptor 8	TLR8	0.0035
3815	Complement C1q subcomponent subunit A	C1QA	0.0034
3816	Complement C1q subcomponent subunit B	C1QB	0.0034
3817	Complement C1q subcomponent subunit C	C1QC	0.0034
899	Glutathione S-transferase Mu 3	GSTM3	0.0034
905	Glutathione transferase omega-1	GSTO1	0.0034
565	Extracellular calcium-sensing receptor	CASR	0.0034
4041	Microsomal glutathione S-transferase 2	MGST2	0.0034
3818	Low affinity immunoglobulin gamma Fc region receptor III-A	FCGR3A	0.0034
712	Tubulin alpha chain	TUB1	0.0034
3819	Low affinity immunoglobulin gamma Fc region receptor II-a	FCGR2A	0.0034
1102	Low affinity immunoglobulin gamma Fc region receptor III-B	FCGR3B	0.0034
3821	Low affinity immunoglobulin gamma Fc region receptor II-c	FCGR2C	0.0034
3814	Complement C1r subcomponent	C1R	0.0034
3820	Low affinity immunoglobulin gamma Fc region receptor II-b	FCGR2B	0.0034
6123	Carbonic anhydrase 5A, mitochondrial	CA5A	0.0033
1525	Heparin-binding growth factor 2	FGF2	0.0033
1970	Protein kinase C alpha type	PRKCA	0.0033
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0033
2236	Casein kinase II subunit alpha	CSNK2A1	0.0033
613	Atrial natriuretic peptide receptor A	NPR1	0.0033
2251	Thymidylate kinase	tmk	0.0033
2254	Thymidylate kinase	DTYMK	0.0033
3522	Thymidylate kinase	tmk	0.0033
3856	Fibroblast growth factor receptor 3	FGFR3	0.0032
1291	cAMP response element-binding protein	CREB1	0.0032
784	High affinity immunoglobulin gamma Fc receptor I	FCGR1A	0.0032
837	Glutamate [NMDA] receptor subunit epsilon-1	GRIN2A	0.0032
2408	Tyrosine-protein kinase SYK	SYK	0.0032
2599	Tyrosine-protein kinase HCK	HCK	0.0032
1760	Aminopeptidase N	ANPEP	0.0032
6843	Aminopeptidase N	pepN	0.0032
4210	Toll-like receptor 4	TLR4	0.0032
2257	Uridine phosphorylase	udp	0.0031
5132	Uridine phosphorylase	udp	0.0031
449	Ornithine decarboxylase	ODC1	0.0031
2165	Glutathione S-transferase Mu 2	GSTM2	0.0031
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0031
6212	Tubulin gamma-1 chain	TUBG1	0.0031
6210	Tubulin delta chain	TUBD1	0.0031
6211	Tubulin epsilon chain	TUBE1	0.0031
207	Glutathione synthetase	GSS	0.0031
5269	Glutathione synthetase	gshB	0.0031
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.003
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.003
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.003
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.003
173	Toll-like receptor 7	TLR7	0.003
1714	Mitogen-activated protein kinase 3	MAPK3	0.003
654	Flavin reductase	BLVRB	0.0029
4192	DNA topoisomerase 2-beta	TOP2B	0.0029
768	FK506-binding protein 1A	FKBP1A	0.0029
901	Glutathione S-transferase Mu 4	GSTM4	0.0029
6080	Neuronal acetylcholine receptor subunit alpha-5	CHRNA5	0.0029
948	Neuronal acetylcholine receptor subunit beta-2	CHRNB2	0.0029
6082	Neuronal acetylcholine receptor subunit beta-3	CHRNB3	0.0029
992	Protein tyrosine kinase 2 beta	PTK2B	0.0028
4252	Penicillin-binding protein 5	dacA	0.0028
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0028
787	Vitamin K epoxide reductase complex subunit 1	VKORC1	0.0028
159	Penicillin-binding protein 2B	penA	0.0028
6121	Penicillin-binding protein 2B	penA	0.0028
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0028
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0027
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0027
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0027
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0027
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0027
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0027
1025	Aquaporin-1	AQP1	0.0027
822	Aldose reductase	AKR1B1	0.0027
3849	Insulin-like growth factor-binding protein 7	IGFBP7	0.0027
2009	Protein NOV homolog	NOV	0.0027
3847	Neuroendocrine convertase 2	PCSK2	0.0027
1949	Carboxypeptidase E	CPE	0.0027
3850	Synaptotagmin-like protein 4	SYTL4	0.0027
3848	Neuroendocrine convertase 1	PCSK1	0.0027
3846	Retinoblastoma-associated protein	RB1	0.0027
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0027
6081	Neuronal acetylcholine receptor subunit alpha-6	CHRNA6	0.0026
6032	PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE)	fas	0.0026
4031	Glutathione S-transferase A1	GSTA1	0.0026
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0026
790	DNA polymerase subunit alpha B	POLA2	0.0026
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0026
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0026
215	Sodium channel protein type 11 subunit alpha	SCN11A	0.0026
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0025
94	5-hydroxytryptamine 4 receptor	HTR4	0.0025
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0025
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0025
707	72 kDa type IV collagenase	MMP2	0.0025
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0024
6102	Arylamine N-acetyltransferase 2	NAT2	0.0023
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0023
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0023
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0023
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0023
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0023
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0023
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0022
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0022
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0022
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0022
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0022
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.0022
760	Fibroblast growth factor 1	FGF1	0.0022
6068	Guanylate cyclase soluble subunit alpha-2	GUCY1A2	0.0022
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0022
2155	Insulin-degrading enzyme	IDE	0.0022
6263	cAMP-dependent protein kinase catalytic subunit alpha	PRKACA	0.0022
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0021
1196	Complement decay-accelerating factor	CD55	0.0021
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.0021
161	Tubulin beta chain	TUBB	0.0021
312	Tubulin beta chain	TUB2	0.0021
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0021
4120	NADPH--cytochrome P450 reductase	POR	0.0021
1820	Beta-nerve growth factor	NGF	0.002
4228	Keratin, type II cytoskeletal 7	KRT7	0.002
716	5-hydroxytryptamine 7 receptor	HTR7	0.0019
2808	Chloramphenicol acetyltransferase 3	cat3	0.0019
512	DNA-directed RNA polymerase alpha chain	rpoA	0.0019
5772	DNA-directed RNA polymerase alpha chain	rpoA	0.0019
122	P2Y purinoceptor 12	P2RY12	0.0018
6766	O-GlcNAcase BT_4395	BT_4395	0.0018
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.0018
1353	DNA topoisomerase 1	TOP1	0.0018
3552	DNA topoisomerase 1	topA	0.0018
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0018
2417	Chloramphenicol acetyltransferase	cat	0.0017
3278	Chloramphenicol acetyltransferase	cat	0.0017
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0017
2810	Dr hemagglutinin structural subunit	draA	0.0017
2718	Chloramphenicol 3-O phosphotransferase	Not Available	0.0017
390	Adenosine A3 receptor	ADORA3	0.0016
1243	Cathepsin D	CTSD	0.0016
427	Substance-P receptor	TACR1	0.0016
1275	Estrogen sulfotransferase	SULT1E1	0.0015
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0015
2499	Tubulin beta-2C chain	TUBB2C	0.0015
3844	HLA class II histocompatibility antigen, DQ(6) alpha chain	HLA-DQA2	0.0015
1050	Bile salt sulfotransferase	SULT2A1	0.0015
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0014
620	Bifunctional dihydrofolate reductase-thymidylate synthase	Not Available	0.0014
2091	Endoplasmin	HSP90B1	0.0014
6859	Protein S100-A4	S100A4	0.0014
291	Nitric-oxide synthase, endothelial	NOS3	0.0013
4010	Mitochondrial dicarboxylate carrier	SLC25A10	0.0013
1410	Oxidoreductase	HSD17B6	0.0013
4725	Oxidoreductase	Not Available	0.0013
5124	Oxidoreductase	Not Available	0.0013
4007	Succinate receptor 1	SUCNR1	0.0013
4008	Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial	OXCT2	0.0013
4002	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial	SUCLG1	0.0013
673	Solute carrier family 13 member 3	SLC13A3	0.0013
391	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial	SUCLG2	0.0013
4009	Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial	SUCLA2	0.0013
498	Solute carrier family 13 member 2	SLC13A2	0.0013
25	Solute carrier family 13 member 1	SLC13A1	0.0013
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0013
3087	Nicotinate-nucleotide adenylyltransferase	nadD	0.0013
4469	Nicotinate-nucleotide adenylyltransferase	nadD	0.0013
4992	Cytochrome c peroxidase	Not Available	0.0013
424	Dihydroorotate dehydrogenase, mitochondrial	DHODH	0.0013
5590	N utilization substance protein B homolog	nusB	0.0012
5598	Glycerol uptake operon antiterminator-related protein	TM_1436	0.0012
5586	Pleckstrin homology domain-containing family A member 1	PLEKHA1	0.0012
5577	N5-carboxyaminoimidazole ribonucleotide mutase	purE	0.0012
3792	KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase	eda	0.0012
2838	Ribose-5-phosphate isomerase A	rpiA	0.0012
2952	Ribose-5-phosphate isomerase A	rpiA	0.0012
5595	Ribose-5-phosphate isomerase A	rpiA	0.0012
4695	UPF0124 protein yfiH	yfiH	0.0012
5060	Intron-associated endonuclease 1	ITEVIR	0.0012
5593	Transferase	Not Available	0.0012
5588	Cell division protein FtsY	TM_0570	0.0012
5591	Complement component C8 gamma chain	C8G	0.0012
5587	Iron(III)-binding periplasmic protein	fbpA	0.0012
5583	RNA 3'-terminal phosphate cyclase	rtcA	0.0012
5582	Regulator of transcription; stringent starvation protein A	sspA	0.0012
5592	Ribonucleoside-diphosphate reductase subunit beta	nrdF	0.0012
5581	Beta-fructosidase	bfrA	0.0012
5600	Pyruvate decarboxylase	pdc	0.0012
4375	Glutamine synthetase 1	glnA1	0.0012
5575	Short tail fiber protein	12	0.0012
5580	Hexon protein	PII	0.0012
5574	Invasin	YPTB1668	0.0012
4311	tRNA	TRDMT1	0.0012
4325	tRNA	trmD	0.0012
4328	tRNA	trmD	0.0012
4003	Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial	OXCT1	0.0012
518	Peroxidase/catalase T	katG	0.0012
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0012
482	Glycine receptor subunit alpha-1	GLRA1	0.0011
4000	Prolyl 4-hydroxylase subunit alpha-2	P4HA2	0.0011
585	Aspartyl/asparaginyl beta-hydroxylase	ASPH	0.0011
1467	Tumor necrosis factor ligand superfamily member 13B	TNFSF13B	0.0011
3940	Gamma-butyrobetaine dioxygenase	BBOX1	0.0011
97	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	0.0011
3938	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	0.0011
3964	Trimethyllysine dioxygenase, mitochondrial	TMLHE	0.0011
3132	Tryptophan synthase alpha chain	trpA	0.0011
6568	Tryptophan synthase alpha chain	trpA	0.0011
5006	RNASE4 protein	RNASE4	0.0011
4006	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	SDHC	0.0011
4001	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	SDHB	0.0011
2555	Pol polyprotein	pol	0.0011
3242	Pol polyprotein	gag-pol	0.0011
3471	Pol polyprotein	gag-pro-pol	0.0011
5256	Pol polyprotein	pol	0.0011
6469	Pol polyprotein	gag-pol	0.0011
6565	Pol polyprotein	Not Available	0.0011
3085	Molybdopterin-guanine dinucleotide biosynthesis protein A	mobA	0.0011
5328	Prostaglandin F synthase	Tb11.02.2310	0.0011
4533	Glyoxalase family protein	BC_1747	0.0011
3729	Citrate synthase	gltA	0.0011
4575	Citrate synthase	cit	0.0011
4580	Citrate synthase	gltA	0.0011
5599	3-carboxy-cis,cis-muconate cycloisomerase	pcaB	0.0011
355	GMP synthase [glutamine-hydrolyzing]	GMPS	0.0011
4353	GMP synthase [glutamine-hydrolyzing]	guaA	0.0011
239	Coagulation factor X	F10	0.001
4366	Riboflavin kinase/FMN adenylyltransferase	TM_0857	0.001
3949	Prolyl 3-hydroxylase 2	LEPREL1	0.001
3945	Prolyl 3-hydroxylase 1	LEPRE1	0.001
3951	Prolyl 3-hydroxylase 3	LEPREL2	0.001
3999	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	SDHD	0.001
4373	Medium-chain-fatty-acid--CoA ligase	Not Available	0.001
197	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	SDHA	0.001
2603	Beta-lactamase II	blm	0.001
2521	Cell division protein ftsZ	ftsZ	0.001
3301	Cell division protein ftsZ	ftsZ	0.001
2149	Angiogenin	ANG	0.001
3583	6-phosphogluconolactonase	pgl	0.001
857	Malate dehydrogenase, mitochondrial	MDH2	0.001
859	Cellular retinoic acid-binding protein 2	CRABP2	0.001
522	26S proteasome non-ATPase regulatory subunit 2	PSMD2	0.001
515	26S proteasome non-ATPase regulatory subunit 1	PSMD1	0.001
823	Fibroblast growth factor receptor 2	FGFR2	0.001
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.001
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.001
1939	Heat shock protein HSP 90-alpha	HSP90AA1	0.001
941	Betaine--homocysteine S-methyltransferase 1	BHMT	0.0009
2942	Sialidase	nanH	0.0009
3546	Sialidase	nedA	0.0009
3486	Fumarate hydratase class II	fumC	0.0009
1123	Eosinophil cationic protein	RNASE3	0.0009
2869	1-deoxy-D-xylulose 5-phosphate reductoisomerase	dxr	0.0009
2286	Isocitrate dehydrogenase [NADP]	icd	0.0009
2302	Isocitrate dehydrogenase [NADP]	icd	0.0009
2771	Isocitrate dehydrogenase [NADP]	icd	0.0009
2452	Tryptophanyl-tRNA synthetase	trpS	0.0009
2697	Uridine-cytidine kinase 2	UCK2	0.0009
2805	Heparan sulfate glucosamine 3-O-sulfotransferase 3A1	HS3ST3A1	0.0009
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0009
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0009
411	Glycine N-methyltransferase	GNMT	0.0009
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0008
5579	Carboxypeptidase B	CPB1	0.0008
3384	Macrophage migration inhibitory factor	MIF	0.0008
128	Adenine phosphoribosyltransferase	APRT	0.0008
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0008
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0008
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0008
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0008
811	Translocator protein	TSPO	0.0008
1374	Natriuretic peptides B	NPPB	0.0008
1827	Gap junction alpha-1 protein	GJA1	0.0008
1908	Vascular cell adhesion protein 1	VCAM1	0.0008
400	Coagulation factor IX	F9	0.0008
5461	Coagulation factor IX	F9	0.0008
4103	Proteasome subunit beta type 2	PSMB2	0.0007
4102	Proteasome subunit beta type 5	PSMB5	0.0007
4101	Proteasome subunit beta type 1	PSMB1	0.0007
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0007
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0007
814	Ryanodine receptor 1	RYR1	0.0007
4081	Vitamin K epoxide reductase complex subunit 1-like protein 1	VKORC1L1	0.0007
604	Vitamin K-dependent protein Z	PROZ	0.0007
6228	Nuclear receptor coactivator 1	NCOA1	0.0007
6241	Nuclear receptor coactivator 2	NCOA2	0.0007
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0007
251	Alcohol dehydrogenase 1A	ADH1A	0.0007
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0007
705	Glutamate receptor 1	GRIA1	0.0007
241	Calcium-transporting ATPase type 2C member 1	ATP2C1	0.0007
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0006
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0006
820	Glycine receptor subunit alpha-2	GLRA2	0.0006
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0006
1245	Vitamin K-dependent protein S	PROS1	0.0006
422	Vitamin K-dependent protein C	PROC	0.0006
537	ATP synthase delta chain, mitochondrial	ATP5D	0.0006
936	Ephrin type-A receptor 2	EPHA2	0.0006
484	Tyrosine-protein kinase ABL2	ABL2	0.0006
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.0006
444	Alcohol dehydrogenase 1B	ADH1B	0.0006
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0006
448	Vitamin K-dependent gamma-carboxylase	GGCX	0.0006
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0005
798	Osteocalcin	BGLAP	0.0005
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0005
369	Coagulation factor VII	F7	0.0005
3937	Fatty-acid amide hydrolase	FAAH	0.0005
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0004
54	Prothrombin	F2	0.0003

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB00917 - Dinoprostone

Targets

Enzymes

Transporters

Predictions