DT-Web

DB01819 - Phosphoenolpyruvate


Identification
Name Phosphoenolpyruvate
Accession Number DB01819 (EXPT02550)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 168.042
Groups experimental
Monoisotopic Weight 167.982374404
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive
Name Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive
Gene Name aroG
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.6449
2-dehydro-3-deoxyphosphooctonate aldolase
Name 2-dehydro-3-deoxyphosphooctonate aldolase
Gene Name kdsA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.8127
Beta-enolase
Name Beta-enolase
Gene Name ENO3
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
Capsule biosynthesis protein
Name Capsule biosynthesis protein
Gene Name synC
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 1.3054
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
Name Phosphoenolpyruvate carboxykinase, cytosolic [GTP]
Gene Name PCK1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.9742
2-dehydro-3-deoxyphosphooctonate aldolase
Name 2-dehydro-3-deoxyphosphooctonate aldolase
Gene Name kdsA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.8127
Phospho-2-dehydro-3-deoxyheptonate aldolase
Name Phospho-2-dehydro-3-deoxyheptonate aldolase
Gene Name aroF
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.9815

Transporters


Solute carrier organic anion transporter family member 2A1
Name Solute carrier organic anion transporter family member 2A1
Gene Name SLCO2A1
Actions inhibitor
References
  • Chan BS, Endo S, Kanai N, Schuster VL: Identification of lactate as a driving force for prostanoid transport by prostaglandin transporter PGT. Am J Physiol Renal Physiol. 2002 Jun;282(6):F1097-102. - Pubmed
DTHybrid score 0.504

Predictions


Id Partner name Gene Name Score
2206 Glucose-6-phosphate isomerase GPI 0.3242
2838 Ribose-5-phosphate isomerase A rpiA 0.2343
2952 Ribose-5-phosphate isomerase A rpiA 0.2343
5595 Ribose-5-phosphate isomerase A rpiA 0.2343
2314 Triosephosphate isomerase TPI 0.1374
3417 Triosephosphate isomerase tpiA 0.1374
3443 Triosephosphate isomerase tpiA 0.1374
6346 Triosephosphate isomerase TPI1 0.1374
2891 Circadian clock protein kaiB kaiB 0.1232
52 Pyruvate kinase isozymes R/L PKLR 0.1151
2248 Malate synthase G glcB 0.1135
3190 Malate synthase G glcB 0.1135
3486 Fumarate hydratase class II fumC 0.1072
2460 ADP-ribose pyrophosphatase nudF 0.0938
4349 ADP-ribose pyrophosphatase ndx4 0.0938
2262 2,3-bisphosphoglycerate-independent phosphoglycerate mutase gpmI 0.0936
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0922
2904 Phosphatase yniC yniC 0.089
3309 6-phosphofructokinase pfkA 0.0775
3192 Glucosamine-6-phosphate deaminase 1 nagB 0.0775
3467 Methylglyoxal synthase mgsA 0.0715
98 Pyruvate kinase isozymes M1/M2 PKM2 0.066
2922 Glycerol kinase glpK 0.0504
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0425
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0425
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0425
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0425
2597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] glmS 0.0403
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0376
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0375
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0373
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0307
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0288
527 Prostacyclin receptor PTGIR 0.0233
2853 14 kDa fatty acid-binding protein Not Available 0.0219
5650 NimA-related protein DR_0842 0.0218
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0218
489 Monocarboxylate transporter 2 SLC16A7 0.0194
500 Monocarboxylate transporter 4 SLC16A3 0.0193
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0175
1024 Solute carrier family 22 member 11 SLC22A11 0.0173
6085 Fatty acid-binding protein, intestinal FABP2 0.0156
738 Monocarboxylate transporter 1 SLC16A1 0.0155
6142 Solute carrier family 22 member 8 SLC22A8 0.0152
2183 Fatty acid-binding protein, adipocyte FABP4 0.015
6136 Multidrug resistance-associated protein 5 ABCC5 0.0147
6151 Monocarboxylate transporter 10 SLC16A10 0.0138
1729 Solute carrier family 22 member 6 SLC22A6 0.0137
587 Serum albumin ALB 0.0132
2164 Multidrug resistance-associated protein 4 ABCC4 0.0123
672 Prostaglandin F2-alpha receptor PTGFR 0.0123
1792 Tissue-type plasminogen activator PLAT 0.0116
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.0104
6143 Solute carrier family 22 member 7 SLC22A7 0.0103
6144 Solute carrier family 22 member 2 SLC22A2 0.0093
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0092
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.009
218 Monocarboxylate transporter 5 SLC16A4 0.0088
195 Monocarboxylate transporter 7 SLC16A6 0.0088
397 Monocarboxylate transporter 3 SLC16A8 0.0088
429 Monocarboxylate transporter 6 SLC16A5 0.0088
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0087
558 Solute carrier family 12 member 1 SLC12A1 0.0084
20 Prostaglandin G/H synthase 1 PTGS1 0.0083
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.008
4757 Cytochrome P450 2C9 CYP2C9 0.008
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0079
771 Pyruvate carboxylase, mitochondrial PC 0.0076
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0075
357 Carbonic anhydrase 2 CA2 0.0067
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0066
118 Organic cation/carnitine transporter 2 SLC22A5 0.0063
199 Monocarboxylate transporter 8 SLC16A2 0.006
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0059
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0053
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0049
6167 Organic solute transporter subunit beta OSTB 0.0047
6166 Organic solute transporter subunit alpha OSTA 0.0047
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0037
4200 Cytochrome P450 1A2 CYP1A2 0.0035
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0034
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0033
468 Cytochrome P450 4A11 CYP4A11 0.0028
3811 Cytochrome P450 19A1 CYP19A1 0.0028
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0027
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0026
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0026
921 Glutamate receptor 2 GRIA2 0.0025
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0025
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0025
6145 Solute carrier family 22 member 1 SLC22A1 0.0025
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0024
6106 Cytochrome P450 2C18 CYP2C18 0.0024
776 Bile salt export pump ABCB11 0.0023
1898 Cytochrome P450 1B1 CYP1B1 0.0023
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0022
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0022
862 Multidrug resistance-associated protein 1 ABCC1 0.0021
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0021
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0021
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0021
5718 Cytochrome P450 2A6 CYP2A6 0.002
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.002
6024 Cytochrome P450 1A1 CYP1A1 0.0019
6030 Cytochrome P450 2B6 CYP2B6 0.0018
6013 Cytochrome P450 2E1 CYP2E1 0.0018
6107 Cytochrome P450 3A7 CYP3A7 0.0017
4118 Cytochrome P450 3A5 CYP3A5 0.0017
4924 Cytochrome P450 2C8 CYP2C8 0.0016
6016 Cytochrome P450 2C19 CYP2C19 0.0016
1588 Multidrug resistance protein 1 ABCB1 0.0015
4512 Cytochrome P450 3A4 CYP3A4 0.0013
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