DT-Web

DB04216 - Quercetin


Identification
Name Quercetin
Accession Number DB04216 (EXPT02732)
Type small molecule
Description A flavonol widely distributed in plants. It is an antioxidant, like many other phenolic heterocyclic compounds. Glycosylated forms include RUTIN and quercetrin. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 302.2357
Groups experimental
Monoisotopic Weight 302.042652674
Pharmacology
Indication Not Available
Mechanism of action Quercetin is a specific quinone reductase 2 (QR2) inhibitor, an enzyme (along with the human QR1 homolog) which catalyzes metabolism of toxic quinolines. Inhibition of QR2 in plasmodium may potentially cause lethal oxidative stress. The inhibition of antioxidant activity in plasmodium may contribute to killing the malaria causing parasites.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Tyrosine-protein kinase HCK
Name Tyrosine-protein kinase HCK
Gene Name HCK
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.808
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Name Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Gene Name PIK3CG
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.4713
UDP-glucuronosyltransferase 3A1
Name UDP-glucuronosyltransferase 3A1
Gene Name UGT3A1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.3877
ATP synthase subunit alpha, mitochondrial
Name ATP synthase subunit alpha, mitochondrial
Gene Name ATP5A1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.7609
ATP synthase subunit beta, mitochondrial
Name ATP synthase subunit beta, mitochondrial
Gene Name ATP5B
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.7609
ATP synthase subunit gamma, mitochondrial
Name ATP synthase subunit gamma, mitochondrial
Gene Name ATP5C1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.761
Proto-oncogene serine/threonine-protein kinase Pim-1
Name Proto-oncogene serine/threonine-protein kinase Pim-1
Gene Name PIM1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.5667
HTH-type transcriptional regulator ttgR
Name HTH-type transcriptional regulator ttgR
Gene Name ttgR
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.1843
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
Name 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
Gene Name HIBCH
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.452
(3R)-hydroxymyristoyl-acyl carrier protein dehydratase
Name (3R)-hydroxymyristoyl-acyl carrier protein dehydratase
Gene Name fabZ
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.9437
Serine/threonine-protein kinase 17B
Name Serine/threonine-protein kinase 17B
Gene Name STK17B
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.4521

Enzymes


Cytochrome P450 2C8
Name Cytochrome P450 2C8
Gene Name CYP2C8
Actions inhibitor
References
DTHybrid score 0.3513

Transporters


Multidrug resistance-associated protein 1
Name Multidrug resistance-associated protein 1
Gene Name ABCC1
Actions inhibitor,inducer
References
  • Kauffmann HM, Pfannschmidt S, Zoller H, Benz A, Vorderstemann B, Webster JI, Schrenk D: Influence of redox-active compounds and PXR-activators on human MRP1 and MRP2 gene expression. Toxicology. 2002 Feb 28;171(2-3):137-46. - Pubmed
  • Leslie EM, Mao Q, Oleschuk CJ, Deeley RG, Cole SP: Modulation of multidrug resistance protein 1 (MRP1/ABCC1) transport and atpase activities by interaction with dietary flavonoids. Mol Pharmacol. 2001 May;59(5):1171-80. - Pubmed
  • Nguyen H, Zhang S, Morris ME: Effect of flavonoids on MRP1-mediated transport in Panc-1 cells. J Pharm Sci. 2003 Feb;92(2):250-7. - Pubmed
DTHybrid score 0.4645
Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions inducer
References
  • Bock KW, Eckle T, Ouzzine M, Fournel-Gigleux S: Coordinate induction by antioxidants of UDP-glucuronosyltransferase UGT1A6 and the apical conjugate export pump MRP2 (multidrug resistance protein 2) in Caco-2 cells. Biochem Pharmacol. 2000 Mar 1;59(5):467-70. - Pubmed
DTHybrid score 0.3789
Monocarboxylate transporter 2
Name Monocarboxylate transporter 2
Gene Name SLC16A7
Actions inhibitor
References
  • Broer S, Broer A, Schneider HP, Stegen C, Halestrap AP, Deitmer JW: Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes. Biochem J. 1999 Aug 1;341 ( Pt 3):529-35. - Pubmed
DTHybrid score 0.6347
Solute carrier organic anion transporter family member 2B1
Name Solute carrier organic anion transporter family member 2B1
Gene Name SLCO2B1
Actions inhibitor
References
  • Satoh H, Yamashita F, Tsujimoto M, Murakami H, Koyabu N, Ohtani H, Sawada Y: Citrus juices inhibit the function of human organic anion-transporting polypeptide OATP-B. Drug Metab Dispos. 2005 Apr;33(4):518-23. Epub 2005 Jan 7. - Pubmed
DTHybrid score 0.489
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Shapiro AB, Ling V: Effect of quercetin on Hoechst 33342 transport by purified and reconstituted P-glycoprotein. Biochem Pharmacol. 1997 Feb 21;53(4):587-96. - Pubmed
  • Eagling VA, Profit L, Back DJ: Inhibition of the CYP3A4-mediated metabolism and P-glycoprotein-mediated transport of the HIV-1 protease inhibitor saquinavir by grapefruit juice components. Br J Clin Pharmacol. 1999 Oct;48(4):543-52. - Pubmed
  • Choi CH, Kim JH, Kim SH: Reversal of P-glycoprotein-mediated MDR by 5,7,3',4',5'-pentamethoxyflavone and SAR. Biochem Biophys Res Commun. 2004 Jul 30;320(3):672-9. - Pubmed
  • Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. - Pubmed
  • Youdim KA, Qaiser MZ, Begley DJ, Rice-Evans CA, Abbott NJ: Flavonoid permeability across an in situ model of the blood-brain barrier. Free Radic Biol Med. 2004 Mar 1;36(5):592-604. - Pubmed
  • Borska S, Sopel M, Chmielewska M, Zabel M, Dziegiel P: Quercetin as a potential modulator of P-glycoprotein expression and function in cells of human pancreatic carcinoma line resistant to daunorubicin. Molecules. 2010 Feb 9;15(2):857-70. - Pubmed
DTHybrid score 0.5666
Monocarboxylate transporter 1
Name Monocarboxylate transporter 1
Gene Name SLC16A1
Actions inhibitor
References
  • Broer S, Broer A, Schneider HP, Stegen C, Halestrap AP, Deitmer JW: Characterization of the high-affinity monocarboxylate transporter MCT2 in Xenopus laevis oocytes. Biochem J. 1999 Aug 1;341 ( Pt 3):529-35. - Pubmed
DTHybrid score 0.6163
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions inhibitor
References
  • Zhang S, Yang X, Morris ME: Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport. Mol Pharmacol. 2004 May;65(5):1208-16. - Pubmed
DTHybrid score 0.4525

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.273
500 Monocarboxylate transporter 4 SLC16A3 0.2633
4757 Cytochrome P450 2C9 CYP2C9 0.2036
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.1919
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.1893
4118 Cytochrome P450 3A5 CYP3A5 0.1464
6016 Cytochrome P450 2C19 CYP2C19 0.1404
4119 Cytochrome P450 2D6 CYP2D6 0.1378
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.1258
504 Mast/stem cell growth factor receptor KIT 0.1203
4200 Cytochrome P450 1A2 CYP1A2 0.1196
4171 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta isoform PIK3CD 0.117
6229 Phosphatidylinositol 3-kinase catalytic subunit type 3 PIK3C3 0.1167
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.1124
6107 Cytochrome P450 3A7 CYP3A7 0.0959
587 Serum albumin ALB 0.0958
1729 Solute carrier family 22 member 6 SLC22A6 0.0922
6030 Cytochrome P450 2B6 CYP2B6 0.0887
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0851
776 Bile salt export pump ABCB11 0.0828
6142 Solute carrier family 22 member 8 SLC22A8 0.081
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0797
2929 (S)-2-haloacid dehalogenase dhlB 0.0787
2995 (S)-2-haloacid dehalogenase Not Available 0.0787
2164 Multidrug resistance-associated protein 4 ABCC4 0.0774
4531 Putative ketoacyl reductase actIII 0.0723
20 Prostaglandin G/H synthase 1 PTGS1 0.0668
6024 Cytochrome P450 1A1 CYP1A1 0.0634
6013 Cytochrome P450 2E1 CYP2E1 0.0611
118 Organic cation/carnitine transporter 2 SLC22A5 0.0591
6145 Solute carrier family 22 member 1 SLC22A1 0.0589
6290 Death-associated protein kinase 3 DAPK3 0.0588
4141 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform PIK3CA 0.0584
6824 Tyrosine-protein kinase Lyn LYN 0.057
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0568
2508 Cyclomaltodextrin glucanotransferase cgt 0.0568
2523 Cyclomaltodextrin glucanotransferase cgt 0.0568
3207 Cyclomaltodextrin glucanotransferase amyA 0.0568
6143 Solute carrier family 22 member 7 SLC22A7 0.0565
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0558
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0556
5650 NimA-related protein DR_0842 0.0548
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0535
1024 Solute carrier family 22 member 11 SLC22A11 0.053
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0521
3184 3-methyl-2-oxobutanoate hydroxymethyltransferase panB 0.0512
3315 3-methyl-2-oxobutanoate hydroxymethyltransferase panB 0.0512
3179 2-isopropylmalate synthase leuA 0.0512
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0505
817 DNA topoisomerase 2-alpha TOP2A 0.0497
2236 Casein kinase II subunit alpha CSNK2A1 0.0494
1898 Cytochrome P450 1B1 CYP1B1 0.0494
6391 Protein kinase C iota type PRKCI 0.0488
6137 Multidrug resistance-associated protein 6 ABCC6 0.0476
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.047
6144 Solute carrier family 22 member 2 SLC22A2 0.0467
6148 Multidrug resistance-associated protein 7 ABCC10 0.0463
290 Prostaglandin G/H synthase 2 PTGS2 0.0455
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0454
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0451
6141 Sodium/bile acid cotransporter SLC10A1 0.0451
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0446
4132 Chloride channel protein ClC-Ka CLCNKA 0.044
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0435
5718 Cytochrome P450 2A6 CYP2A6 0.0432
6246 Serine/threonine-protein kinase PLK1 PLK1 0.0422
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0421
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0411
3334 Deacetoxycephalosporin C synthetase cefE 0.0408
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0385
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0385
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0364
2240 Cell division protein kinase 2 CDK2 0.0363
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0358
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0355
6136 Multidrug resistance-associated protein 5 ABCC5 0.0354
136 Estrogen receptor ESR1 0.0344
6151 Monocarboxylate transporter 10 SLC16A10 0.0337
6106 Cytochrome P450 2C18 CYP2C18 0.0333
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0318
2530 Protein kinase C theta type PRKCQ 0.0307
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.0305
2473 Tyrosine-protein kinase CSK CSK 0.0302
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.0302
723 Cytosolic phospholipase A2 PLA2G4A 0.0298
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0296
6500 Phospholipase A2 PLA2G1B 0.0288
731 HIV-1 protease HIV-1 protease 0.0286
6149 Solute carrier family 22 member 10 SLC22A10 0.0281
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0263
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0262
6147 Solute carrier family 22 member 3 SLC22A3 0.0259
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0257
70 Type-1 angiotensin II receptor AGTR1 0.0255
844 Epidermal growth factor receptor EGFR 0.0248
33 Cystine/glutamate transporter SLC7A11 0.0233
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0229
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0223
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0219
1353 DNA topoisomerase 1 TOP1 0.0217
3552 DNA topoisomerase 1 topA 0.0217
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0215
833 Organic cation/carnitine transporter 1 SLC22A4 0.0215
3811 Cytochrome P450 19A1 CYP19A1 0.0214
2408 Tyrosine-protein kinase SYK SYK 0.0211
477 DNA topoisomerase 4 subunit A parC 0.0206
886 DNA topoisomerase 4 subunit A parC 0.0206
6226 DNA topoisomerase 4 subunit A parC 0.0206
6167 Organic solute transporter subunit beta OSTB 0.0206
6166 Organic solute transporter subunit alpha OSTA 0.0205
404 DNA gyrase subunit A gyrA 0.0203
6224 DNA gyrase subunit A gyrA 0.0203
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.02
871 Glucocorticoid receptor NR3C1 0.0198
468 Cytochrome P450 4A11 CYP4A11 0.0195
29 Tubulin beta-1 chain TUBB1 0.0193
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0192
556 Alpha-1A adrenergic receptor ADRA1A 0.0189
860 Nicotinamide N-methyltransferase NNMT 0.0183
928 Nicotinic acid receptor 2 GPR109B 0.0183
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0183
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0183
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0183
699 Nicotinic acid receptor 1 GPR109A 0.0183
24 Thymidylate synthase TMP1 0.0182
359 Thymidylate synthase TYMS 0.0182
2626 Thymidylate synthase thyA 0.0182
2729 Thymidylate synthase thyA 0.0182
5352 Thymidylate synthase THYA 0.0182
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0181
1721 Glycogen synthase kinase-3 beta GSK3B 0.018
397 Monocarboxylate transporter 3 SLC16A8 0.0178
195 Monocarboxylate transporter 7 SLC16A6 0.0177
429 Monocarboxylate transporter 6 SLC16A5 0.0177
218 Monocarboxylate transporter 5 SLC16A4 0.0177
161 Tubulin beta chain TUBB 0.0174
312 Tubulin beta chain TUB2 0.0174
4604 Liver carboxylesterase 1 CES1 0.0172
672 Prostaglandin F2-alpha receptor PTGFR 0.0171
492 Histamine H1 receptor HRH1 0.017
220 Sodium channel protein type 5 subunit alpha SCN5A 0.017
4120 NADPH--cytochrome P450 reductase POR 0.017
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0168
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0167
614 Progesterone receptor PGR 0.0167
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0165
52 Pyruvate kinase isozymes R/L PKLR 0.0164
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0164
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0163
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0162
275 Arachidonate 5-lipoxygenase ALOX5 0.0161
824 Sodium-dependent serotonin transporter SLC6A4 0.016
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0158
13 Aminomethyltransferase, mitochondrial AMT 0.0154
869 Estrogen receptor beta ESR2 0.0153
273 Apoptosis regulator Bcl-2 BCL2 0.0153
6085 Fatty acid-binding protein, intestinal FABP2 0.0152
771 Pyruvate carboxylase, mitochondrial PC 0.0149
338 DNA polymerase UL30 0.0149
379 DNA polymerase UL54 0.0149
697 DNA polymerase ORF28 0.0149
2482 DNA polymerase 43 0.0149
4104 DNA polymerase BALF5 0.0149
98 Pyruvate kinase isozymes M1/M2 PKM2 0.0148
908 Glutathione S-transferase theta-1 GSTT1 0.0146
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0144
199 Monocarboxylate transporter 8 SLC16A2 0.0141
228 Beta platelet-derived growth factor receptor PDGFRB 0.0141
6218 Pannexin-1 PANX1 0.0141
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0138
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0136
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0136
320 5-hydroxytryptamine 1A receptor HTR1A 0.0135
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0135
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0133
380 Cytochrome P450 17A1 CYP17A1 0.0132
26 Vascular endothelial growth factor receptor 3 FLT4 0.0132
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0132
952 Dipeptidyl peptidase 4 DPP4 0.0131
1852 Microtubule-associated protein 2 MAP2 0.0131
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.013
3307 Acriflavine resistance protein B acrB 0.013
3923 Cholinesterase BCHE 0.0128
32 Vascular endothelial growth factor receptor 1 FLT1 0.0127
904 Glutathione S-transferase P GSTP1 0.0126
4192 DNA topoisomerase 2-beta TOP2B 0.0125
5923 Microtubule-associated protein tau MAPT 0.0124
5924 Microtubule-associated protein 4 MAP4 0.0124
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0124
461 Glycine receptor subunit alpha-3 GLRA3 0.0124
117 Sterol O-acyltransferase 1 SOAT1 0.0123
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0122
3587 Gastrotropin FABP6 0.0122
6182 Cytochrome P450 2J2 CYP2J2 0.0121
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0121
1650 Heme carrier protein 1 SLC46A1 0.0121
2539 Tubulin alpha-1 chain TUBA4A 0.0121
407 Vascular endothelial growth factor receptor 2 KDR 0.012
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0119
318 Alpha-2A adrenergic receptor ADRA2A 0.0119
831 D(2) dopamine receptor DRD2 0.0118
3947 Xanthine dehydrogenase/oxidase XDH 0.0118
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0118
2331 HTH-type transcriptional regulator qacR qacR 0.0118
6461 HTH-type transcriptional regulator qacR qacR 0.0118
4773 Deoxycytidine kinase DCK 0.0117
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0117
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0115
6031 Cytochrome P450 3A43 CYP3A43 0.0114
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0112
3014 Ribonuclease UK114 HRSP12 0.011
5428 Replication protein repA 0.011
3617 Non-heme chloroperoxidase cpo 0.011
5426 Non-heme chloroperoxidase cpo 0.011
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.011
3718 Hydrogen peroxide-inducible genes activator oxyR 0.011
3018 HTH-type transcriptional regulator malT malT 0.011
992 Protein tyrosine kinase 2 beta PTK2B 0.0109
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0109
2443 Azurin azu 0.0108
5787 Angiopoietin-1 receptor TEK 0.0107
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0107
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0106
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0104
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0103
502 5-hydroxytryptamine 2A receptor HTR2A 0.0101
467 Delta-type opioid receptor OPRD1 0.0101
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0101
847 Mu-type opioid receptor OPRM1 0.01
1792 Tissue-type plasminogen activator PLAT 0.01
696 Kappa-type opioid receptor OPRK1 0.01
193 Beta-1 adrenergic receptor ADRB1 0.0099
373 Transthyretin TTR 0.0098
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0098
3361 Serpin B5 SERPINB5 0.0097
5694 Transcription antiterminator licT licT 0.0097
6220 Aryl hydrocarbon receptor AHR 0.0097
5691 DTDP-4-DEHYDRORHAMNOSE 3,5-EPIMERASE RMLC rmlC 0.0097
165 FL cytokine receptor FLT3 0.0096
6146 High affinity copper uptake protein 1 SLC31A1 0.0096
185 Vasopressin V1a receptor AVPR1A 0.0096
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0095
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0095
10 Glycogen phosphorylase, liver form PYGL 0.0095
146 Androgen receptor AR 0.0095
737 Mineralocorticoid receptor NR3C2 0.0095
6058 Geranylgeranyl pyrophosphate synthetase GGPS1 0.0095
1629 Transcription factor AP-1 JUN 0.0095
2958 Probable tautomerase ydcE pptA 0.0095
2573 Cocaine esterase cocE 0.0094
7263 Cocaine esterase Not Available 0.0094
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0094
322 Vasopressin V2 receptor AVPR2 0.0093
3115 Ras-related protein Rab-9 RAB9A 0.0093
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0093
853 Farnesyl pyrophosphate synthetase FDPS 0.0092
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.0091
6163 Copper-transporting ATPase 2 ATP7B 0.0091
6165 Copper-transporting ATPase 1 ATP7A 0.0091
756 Sex hormone-binding globulin SHBG 0.0091
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.009
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.009
5626 Nucleoside diphosphate kinase B NME2 0.0089
3917 Methylenetetrahydrofolate reductase MTHFR 0.0089
1192 Sulfotransferase 1A1 SULT1A1 0.0088
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0088
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0088
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0087
766 Beta-2 adrenergic receptor ADRB2 0.0087
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0086
896 Glutathione S-transferase Mu 1 GSTM1 0.0086
3941 Amine oxidase [flavin-containing] A MAOA 0.0086
465 Calmodulin CALM1 0.0085
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0085
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0084
365 Dihydrofolate reductase DHFR 0.0084
2381 Dihydrofolate reductase DFR1 0.0084
2833 Dihydrofolate reductase Not Available 0.0084
2931 Dihydrofolate reductase folA 0.0084
3544 Dihydrofolate reductase folA 0.0084
3682 Dihydrofolate reductase folA 0.0084
6642 Dihydrofolate reductase folA 0.0084
6756 Dihydrofolate reductase dfrA 0.0084
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0084
293 Gamma-glutamyl hydrolase GGH 0.0084
2286 Isocitrate dehydrogenase [NADP] icd 0.0083
2302 Isocitrate dehydrogenase [NADP] icd 0.0083
2771 Isocitrate dehydrogenase [NADP] icd 0.0083
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0082
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0082
1757 Myeloperoxidase MPO 0.0082
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0082
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0082
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0082
632 Alpha-1B adrenergic receptor ADRA1B 0.0082
3602 Anti-sigma F factor antagonist spoIIAA 0.0082
2514 Phosphocarrier protein HPr ptsH 0.0082
5689 Phosphocarrier protein HPr ptsH 0.0082
5686 Potassium voltage-gated channel subfamily C member 4 KCNC4 0.0082
850 Vasopressin V1b receptor AVPR1B 0.0081
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0081
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.008
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0079
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0079
6138 Multidrug resistance protein 3 ABCB4 0.0079
56 Delta-aminolevulinic acid dehydratase ALAD 0.0078
2356 Delta-aminolevulinic acid dehydratase hemB 0.0078
3613 Delta-aminolevulinic acid dehydratase hemB 0.0078
3674 Delta-aminolevulinic acid dehydratase hemB 0.0078
260 Cytochrome P450 51 ERG11 0.0077
761 Cytochrome P450 51 ERG11 0.0077
3163 Cytochrome P450 51 cyp51 0.0077
2449 Tubulin alpha-3 chain TUBA1A 0.0075
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0075
603 DNA polymerase alpha catalytic subunit POLA1 0.0074
5294 Nucleoside diphosphate kinase A NME1 0.0073
2808 Chloramphenicol acetyltransferase 3 cat3 0.0073
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0073
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0073
3810 Catechol O-methyltransferase COMT 0.0073
1291 cAMP response element-binding protein CREB1 0.0072
2693 Heat-labile enterotoxin B chain eltB 0.0072
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0072
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0071
1130 Lithostathine 1 alpha REG1A 0.0071
4542 Glutaminase 1 glsA1 0.0071
4544 Glutaminase 1 glsA1 0.0071
4534 Cytohesin-2 CYTH2 0.0071
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0071
5818 Folate receptor alpha FOLR1 0.007
6645 D-amino-acid oxidase DAO 0.007
777 Tumor necrosis factor TNF 0.007
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.007
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.007
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0069
789 Alpha-1D adrenergic receptor ADRA1D 0.0069
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0069
3668 Maltose-binding periplasmic protein precursor malE 0.0068
1050 Bile salt sulfotransferase SULT2A1 0.0068
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0068
469 Annexin A1 ANXA1 0.0067
725 5-hydroxytryptamine 1D receptor HTR1D 0.0067
885 5-hydroxytryptamine 1B receptor HTR1B 0.0067
702 UMP-CMP kinase CMPK1 0.0067
4238 50S ribosomal protein L4 rplD 0.0067
5578 50S ribosomal protein L4 rplD 0.0067
6173 50S ribosomal protein L4 rplD 0.0067
6219 50S ribosomal protein L4 rplD 0.0067
543 Penicillin-binding protein 1B mrcB 0.0067
6186 Penicillin-binding protein 1B ponB 0.0067
6822 Penicillin-binding protein 1b pbp1b 0.0067
6844 Penicillin-binding protein 1b pbp1b 0.0067
2183 Fatty acid-binding protein, adipocyte FABP4 0.0066
4318 Siroheme synthase cysG 0.0066
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0065
3119 Fimbrial protein pilE1 0.0065
645 Penicillin-binding protein 1A mrcA 0.0065
5805 Penicillin-binding protein 1A ponA 0.0065
6185 Penicillin-binding protein 1A mrcA 0.0065
6799 Penicillin-binding protein 1A pbpA 0.0065
183 Vascular endothelial growth factor A VEGFA 0.0065
342 P protein [Includes: DNA-directed DNA polymerase P 0.0065
612 P protein [Includes: DNA-directed DNA polymerase P 0.0065
159 Penicillin-binding protein 2B penA 0.0064
6121 Penicillin-binding protein 2B penA 0.0064
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0064
2021 Thrombomodulin THBD 0.0064
6210 Tubulin delta chain TUBD1 0.0064
6212 Tubulin gamma-1 chain TUBG1 0.0064
6211 Tubulin epsilon chain TUBE1 0.0064
3856 Fibroblast growth factor receptor 3 FGFR3 0.0064
23 D(1A) dopamine receptor DRD1 0.0064
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0063
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
244 Angiotensin-converting enzyme ACE 0.0063
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
936 Ephrin type-A receptor 2 EPHA2 0.0063
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0063
3270 Elongation factor G fusA 0.0062
3453 Alkaline phosphatase phoA 0.0062
4237 50S ribosomal protein L22 rplV 0.0062
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0061
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0061
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0061
297 Adenylate cyclase type 1 ADCY1 0.0061
2592 Beta-galactosidase lacZ 0.0061
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
3868 Calcineurin subunit B isoform 2 PPP3R2 0.006
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.006
122 P2Y purinoceptor 12 P2RY12 0.006
2503 Phosphomannomutase/phosphoglucomutase algC 0.0059
2684 Histidine triad nucleotide-binding protein 1 HINT1 0.0059
5150 Endo-1,4-beta-xylanase Y xynY 0.0059
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0059
3809 Estrogen-related receptor gamma ESRRG 0.0058
2207 Rhodopsin RHO 0.0058
851 5'-AMP-activated protein kinase subunit beta-2 PRKAB2 0.0058
388 AMP deaminase 1 AMPD1 0.0058
1760 Aminopeptidase N ANPEP 0.0058
6843 Aminopeptidase N pepN 0.0058
315 Arginase-1 ARG1 0.0057
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0057
128 Adenine phosphoribosyltransferase APRT 0.0057
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0057
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0057
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0056
6021 Adenosine kinase ADK 0.0056
6020 Aldehyde oxidase AOX1 0.0056
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0055
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0055
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0054
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0054
4198 Fructose-1,6-bisphosphatase 1 FBP1 0.0054
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0053
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0053
527 Prostacyclin receptor PTGIR 0.0052
713 Sodium-dependent dopamine transporter SLC6A3 0.0052
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0052
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0051
284 DNA-directed RNA polymerase beta chain rpoB 0.0051
5773 DNA-directed RNA polymerase beta chain rpoB 0.0051
1152 Glycogen phosphorylase, muscle form PYGM 0.005
436 5-hydroxytryptamine 2B receptor HTR2B 0.005
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.005
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.005
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0049
590 5-hydroxytryptamine 2C receptor HTR2C 0.0049
3939 Amine oxidase [flavin-containing] B MAOB 0.0049
124 Histamine H2 receptor HRH2 0.0048
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0048
6228 Nuclear receptor coactivator 1 NCOA1 0.0047
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0047
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0047
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0047
6241 Nuclear receptor coactivator 2 NCOA2 0.0047
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0047
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0047
7 Nitric oxide synthase, inducible NOS2 0.0045
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0045
239 Coagulation factor X F10 0.0044
811 Translocator protein TSPO 0.0044
6102 Arylamine N-acetyltransferase 2 NAT2 0.0043
823 Fibroblast growth factor receptor 2 FGFR2 0.0042
638 D(3) dopamine receptor DRD3 0.0042
1039 Histone deacetylase 9 HDAC9 0.0042
1618 High affinity nerve growth factor receptor NTRK1 0.0042
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0042
558 Solute carrier family 12 member 1 SLC12A1 0.0042
131 Synaptic vesicular amine transporter SLC18A2 0.0041
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0041
1123 Eosinophil cationic protein RNASE3 0.0041
511 5-hydroxytryptamine 1F receptor HTR1F 0.004
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.004
5300 Antigen peptide transporter 1 TAP1 0.004
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.004
198 Sodium channel protein type 10 subunit alpha SCN10A 0.004
474 Acetylcholinesterase ACHE 0.004
2981 Phospholipase A2, membrane associated PLA2G2A 0.0039
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0039
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0039
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0039
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0038
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0038
6168 Solute carrier family 22 member 16 SLC22A16 0.0038
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0038
84 Nuclear receptor 0B1 NR0B1 0.0038
2232 Interleukin-5 IL5 0.0037
1593 Mucin-2 MUC2 0.0037
106 Cannabinoid receptor 2 CNR2 0.0037
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0037
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0037
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0037
1630 Integrin beta-2 ITGB2 0.0036
921 Glutamate receptor 2 GRIA2 0.0036
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0036
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0036
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0036
68 Cannabinoid receptor 1 CNR1 0.0036
1569 G1/S-specific cyclin-D1 CCND1 0.0036
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0036
1313 Lactoylglutathione lyase GLO1 0.0035
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0035
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0035
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0035
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0035
1541 Metalloproteinase mmp20 0.0035
88 Retinoic acid receptor RXR-beta RXRB 0.0034
319 Opioid receptor, sigma 1 OPRS1 0.0034
594 Thyroxine-binding globulin SERPINA7 0.0034
162 Retinoic acid receptor gamma-1 RARG 0.0034
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0033
1010 Cytochrome P450 51A1 CYP51A1 0.0033
4103 Proteasome subunit beta type 2 PSMB2 0.0033
4102 Proteasome subunit beta type 5 PSMB5 0.0033
4101 Proteasome subunit beta type 1 PSMB1 0.0033
3932 Glutathione S-transferase A2 GSTA2 0.0033
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0033
2216 Fibroblast growth factor receptor 4 FGFR4 0.0033
5880 Thrombopoietin receptor MPL 0.0033
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0033
4217 Telomerase reverse transcriptase TERT 0.0033
2852 DNA mismatch repair protein mutL mutL 0.0033
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0032
3794 Osmolarity sensor protein envZ envZ 0.0032
5641 Rod shape-determining protein MreB TM_0588 0.0032
4178 DNA repair protein RAD51 homolog 1 RAD51 0.0032
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0032
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0032
5645 DNA topoisomerase 4 subunit B parE 0.0032
6227 DNA topoisomerase 4 subunit B parE 0.0032
5643 General secretion pathway protein E epsE 0.0032
5644 Sensor protein phoQ phoQ 0.0032
5642 Chaperone clpB clpB 0.0032
5649 Potassium-transporting ATPase B chain kdpB 0.0032
4122 Histone deacetylase 2 HDAC2 0.0032
229 Retinoic acid receptor beta RARB 0.0032
207 Glutathione synthetase GSS 0.0031
5269 Glutathione synthetase gshB 0.0031
2499 Tubulin beta-2C chain TUBB2C 0.0031
730 Retinoic acid receptor alpha RARA 0.0031
758 Thyroid hormone receptor alpha THRA 0.0031
629 Alpha-2B adrenergic receptor ADRA2B 0.0031
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0031
891 Dihydropteroate synthase folP 0.003
5359 Dihydropteroate synthase folP 0.003
7175 Dihydropteroate synthase sulI 0.003
484 Tyrosine-protein kinase ABL2 ABL2 0.003
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.003
6042 Prostaglandin reductase 2 PTGR2 0.003
4203 Histamine N-methyltransferase HNMT 0.003
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.003
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0029
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0029
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0029
6044 Serum paraoxonase/lactonase 3 PON3 0.0029
1714 Mitogen-activated protein kinase 3 MAPK3 0.0029
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0029
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
683 Potassium transporter GK0582 0.0029
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0029
2391 Ferrochelatase hemH 0.0029
6502 Ferrochelatase DKFZp686P18130 0.0029
1591 Ferrochelatase, mitochondrial FECH 0.0029
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0028
2282 Protein recA recA 0.0028
2315 Protein recA recA 0.0028
2332 Protein recA recA 0.0028
5263 Protein recA recA 0.0028
5646 Galactokinase GALK1 0.0028
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0028
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0028
5302 TrwB trwB 0.0028
5265 FtsH ftsH 0.0028
2112 Toll-like receptor 9 TLR9 0.0028
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0028
2867 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ispE 0.0028
6433 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 PFKFB4 0.0028
1178 Adenosine A2a receptor ADORA2A 0.0028
4751 Mitogen-activated protein kinase 12 MAPK12 0.0028
2397 Dihydroxyacetone kinase dhaK 0.0028
346 Thyroid hormone receptor beta-1 THRB 0.0028
6043 Putative G-protein coupled receptor 44 GPR44 0.0028
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
572 Integrin alpha-L ITGAL 0.0027
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0027
76 Nitric-oxide synthase, brain NOS1 0.0027
818 50S ribosomal protein L10 rplJ 0.0026
5798 Mitogen-activated protein kinase 11 MAPK11 0.0026
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0026
427 Substance-P receptor TACR1 0.0026
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0026
4226 Uridine phosphorylase 2 UPP2 0.0026
5312 Kinesin-like protein KIF1A KIF1A 0.0026
291 Nitric-oxide synthase, endothelial NOS3 0.0026
2320 Thymidine kinase, cytosolic TK1 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
2299 UDP-N-acetylmuramate--L-alanine ligase murC 0.0026
804 Mitochondrial folate transporter/carrier SLC25A32 0.0026
718 Folate receptor gamma FOLR3 0.0026
299 Folate receptor beta FOLR2 0.0026
3231 Death-associated protein kinase 1 DAPK1 0.0026
3959 Cell division protein kinase 4 CDK4 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0025
6174 50S ribosomal protein L32 rpmF 0.0025
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
4116 Dihydropteroate synthetase Not Available 0.0025
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0025
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0025
6493 Cytochrome c oxidase subunit 6C COX6C 0.0025
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0025
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0025
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0025
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0025
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0025
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0025
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0025
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0025
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0025
6559 Cytochrome c oxidase subunit 2 ctaC 0.0025
6669 Cytochrome c oxidase subunit 2 ctaC 0.0025
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0025
6558 Cytochrome c oxidase subunit 1 ctaD 0.0025
2615 Chemotaxis protein cheA cheA 0.0024
4225 Uridine phosphorylase 1 UPP1 0.0024
1881 Hexokinase-1 HK1 0.0024
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0024
2371 Pantothenate kinase coaA 0.0024
2892 Acetylglutamate kinase argB 0.0024
3550 Acetylglutamate kinase argB 0.0024
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0024
716 5-hydroxytryptamine 7 receptor HTR7 0.0024
4148 Serine/threonine-protein kinase mTOR MTOR 0.0024
760 Fibroblast growth factor 1 FGF1 0.0024
341 5-hydroxytryptamine 3 receptor HTR3A 0.0024
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0024
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0024
1176 Mitogen-activated protein kinase 1 MAPK1 0.0024
6171 Solute carrier family 28 member 3 SLC28A3 0.0024
3955 Cell division protein kinase 6 CDK6 0.0023
1063 Signal transducer and activator of transcription 5B STAT5B 0.0023
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
2727 S-adenosylmethionine synthetase metK 0.0023
5816 Cadherin-5 CDH5 0.0023
378 Alpha-2C adrenergic receptor ADRA2C 0.0023
751 Potassium channel subfamily K member 6 KCNK6 0.0023
887 DNA gyrase subunit B gyrB 0.0023
4150 DNA gyrase subunit B gyrB 0.0023
6225 DNA gyrase subunit B gyrB 0.0023
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0023
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0023
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0023
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0023
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0023
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0023
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0023
6014 Cytochrome P450 2A13 CYP2A13 0.0023
2540 Choloylglycine hydrolase cbh 0.0023
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0022
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0022
413 Amidophosphoribosyltransferase PPAT 0.0022
2515 Amidophosphoribosyltransferase purF 0.0022
3714 Amidophosphoribosyltransferase purF 0.0022
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0022
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0022
6111 DNA polymerase epsilon subunit 4 POLE4 0.0022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0022
6110 DNA polymerase epsilon subunit 2 POLE2 0.0022
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0022
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0022
94 5-hydroxytryptamine 4 receptor HTR4 0.0022
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0022
3086 Plasmepsin-2 Not Available 0.0022
1648 Elastin ELN 0.0022
4210 Toll-like receptor 4 TLR4 0.0022
1262 Corticotropin-lipotropin POMC 0.0021
6501 Fatty acid-binding protein, liver FABP1 0.0021
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0021
172 Potassium channel subfamily K member 1 KCNK1 0.0021
208 DNA-directed RNA polymerase beta' chain rpoC 0.0021
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0021
958 Insulin-like growth factor 1 receptor IGF1R 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
6459 Glycodelin PAEP 0.002
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
5433 UPF0230 protein TM_1468 TM_1468 0.002
3616 Fatty acid-binding protein, epidermal FABP5 0.002
5431 Lipid binding protein Not Available 0.002
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.002
2251 Thymidylate kinase tmk 0.002
2254 Thymidylate kinase DTYMK 0.002
3522 Thymidylate kinase tmk 0.002
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.002
4311 tRNA TRDMT1 0.002
4325 tRNA trmD 0.002
4328 tRNA trmD 0.002
1656 CYP2B protein CYP2B 0.002
1058 Cell division protein kinase 5 CDK5 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0019
735 Alanine aminotransferase 1 GPT 0.0019
3904 Alanine aminotransferase 2 GPT2 0.0019
3822 Actin, alpha skeletal muscle ACTA1 0.0019
16 Adenosine A1 receptor ADORA1 0.0019
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0019
3639 Thymidine phosphorylase deoA 0.0019
3936 Thymidine phosphorylase TYMP 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0018
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
3763 5,10-methylenetetrahydrofolate reductase metF 0.0018
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0018
5094 5,10-methylenetetrahydrofolate reductase metF 0.0018
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
1836 Mitogen-activated protein kinase 10 MAPK10 0.0018
1864 RET proto-oncogene RET 0.0018
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0018
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0018
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0018
6103 Arylamine N-acetyltransferase 1 NAT1 0.0018
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0017
283 SEC14-like protein 2 SEC14L2 0.0017
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0017
1928 Leukotriene C4 synthase LTC4S 0.0017
4034 Glutaredoxin-1 GLRX 0.0017
910 Epididymal secretory glutathione peroxidase GPX5 0.0017
4037 Hypothetical protein GPX1 0.0017
4297 Hypothetical protein SP_1951 0.0017
4521 Hypothetical protein BC_2969 0.0017
4540 Hypothetical protein TM_1070 0.0017
4555 Hypothetical protein MT1739 0.0017
4569 Hypothetical protein mshD 0.0017
4578 Hypothetical protein PA3270 0.0017
4747 Hypothetical protein PA3967 0.0017
5177 Hypothetical protein TM_0096 0.0017
5194 Hypothetical protein PA1204 0.0017
5240 Hypothetical protein Rv2991 0.0017
5370 Hypothetical protein TM_1158 0.0017
5710 Hypothetical protein Tb927.5.1360 0.0017
4029 Microsomal glutathione S-transferase 3 MGST3 0.0017
4036 Glutathione peroxidase 6 GPX6 0.0017
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0017
4032 Microsomal glutathione S-transferase 1 MGST1 0.0017
903 Glutathione S-transferase A5 GSTA5 0.0017
4040 Glutathione peroxidase 7 GPX7 0.0017
907 Glutathione peroxidase 2 GPX2 0.0017
900 Glutathione S-transferase A4 GSTA4 0.0017
911 Glutathione peroxidase 3 GPX3 0.0017
906 Glutathione peroxidase 1 GPX1 0.0017
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0017
4035 Glutathione S-transferase Mu 5 GSTM5 0.0017
4042 Glutathione transferase omega-2 GSTO2 0.0017
4038 Glutathione peroxidase 4 GPX4 0.0017
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0017
4033 S-formylglutathione hydrolase ESD 0.0017
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0017
768 FK506-binding protein 1A FKBP1A 0.0017
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0017
518 Peroxidase/catalase T katG 0.0016
976 Platelet glycoprotein IX GP9 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0016
605 Fumarate reductase flavoprotein subunit frdA 0.0016
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0016
3673 Fumarate reductase flavoprotein subunit fccA 0.0016
4912 Fumarate reductase flavoprotein subunit ifcA 0.0016
6549 Fumarate reductase flavoprotein subunit frdA 0.0016
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0016
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0016
2211 Fatty acid-binding protein, heart FABP3 0.0016
528 5-hydroxytryptamine 1E receptor HTR1E 0.0016
517 Alcohol dehydrogenase 1C ADH1C 0.0016
3319 Hydroxyacylglutathione hydrolase HAGH 0.0016
898 Glutathione S-transferase A3 GSTA3 0.0016
897 Glutathione S-transferase kappa 1 GSTK1 0.0015
814 Ryanodine receptor 1 RYR1 0.0015
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0015
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0015
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0015
6755 Poliovirus receptor PVR 0.0015
909 Maleylacetoacetate isomerase GSTZ1 0.0015
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0015
1517 Beta-3 adrenergic receptor ADRB3 0.0015
6677 Myelin P2 protein PMP2 0.0015
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0015
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0015
899 Glutathione S-transferase Mu 3 GSTM3 0.0015
905 Glutathione transferase omega-1 GSTO1 0.0015
3957 Adenosine deaminase ADA 0.0015
340 Apoptotic protease-activating factor 1 APAF1 0.0015
1196 Complement decay-accelerating factor CD55 0.0015
6033 High affinity interleukin-8 receptor A CXCR1 0.0015
1770 Phospholipase C PLCL1 0.0015
2841 Phospholipase C plc 0.0015
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0015
4041 Microsomal glutathione S-transferase 2 MGST2 0.0015
174 Sigma 1-type opioid receptor SIGMAR1 0.0014
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0014
357 Carbonic anhydrase 2 CA2 0.0014
4992 Cytochrome c peroxidase Not Available 0.0014
6048 Troponin C, skeletal muscle TNNC2 0.0014
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
432 D(4) dopamine receptor DRD4 0.0014
780 Retinoic acid receptor RXR-gamma RXRG 0.0014
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0014
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0014
2165 Glutathione S-transferase Mu 2 GSTM2 0.0014
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0014
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0014
277 Purine nucleoside phosphorylase PNP 0.0014
2870 Purine nucleoside phosphorylase punA 0.0014
2945 Purine nucleoside phosphorylase punA 0.0014
4659 Purine nucleoside phosphorylase TM_1596 0.0014
4825 Purine nucleoside phosphorylase TTHA1435 0.0014
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0013
634 Squalene monooxygenase SQLE 0.0013
7196 Squalene monooxygenase ERG1 0.0013
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0013
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0013
1912 Excitatory amino acid transporter 1 SLC1A3 0.0013
4019 Excitatory amino acid transporter 4 SLC1A6 0.0013
922 Glutamate receptor 4 GRIA4 0.0013
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0013
4026 Aspartyl aminopeptidase DNPEP 0.0013
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0013
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0013
4016 Excitatory amino acid transporter 5 SLC1A7 0.0013
1047 Excitatory amino acid transporter 2 SLC1A2 0.0013
927 Metabotropic glutamate receptor 8 GRM8 0.0013
664 Glutamate decarboxylase 2 GAD2 0.0013
3890 Glutamate decarboxylase 2 GAD2 0.0013
4020 Glutamyl aminopeptidase ENPEP 0.0013
4018 Glutamate receptor delta-2 subunit GRID2 0.0013
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0013
925 Metabotropic glutamate receptor 4 GRM4 0.0013
926 Metabotropic glutamate receptor 7 GRM7 0.0013
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0013
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0013
4027 Glutamate receptor delta-1 subunit GRID1 0.0013
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0013
4017 5-oxoprolinase OPLAH 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
825 Arsenical pump-driving ATPase ASNA1 0.0013
3435 Arsenical pump-driving ATPase arsA 0.0013
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0013
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0013
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0013
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0013
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0013
733 Activin receptor type 1B ACVR1B 0.0013
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0013
154 AFG3-like protein 2 AFG3L2 0.0013
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0013
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0013
395 ALK tyrosine kinase receptor Not Available 0.0013
901 Glutathione S-transferase Mu 4 GSTM4 0.0013
6432 Transporter snf 0.0013
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0013
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0013
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0012
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0012
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0012
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
5590 N utilization substance protein B homolog nusB 0.0012
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0012
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.0012
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0012
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0012
2838 Ribose-5-phosphate isomerase A rpiA 0.0012
2952 Ribose-5-phosphate isomerase A rpiA 0.0012
5595 Ribose-5-phosphate isomerase A rpiA 0.0012
4695 UPF0124 protein yfiH yfiH 0.0012
5060 Intron-associated endonuclease 1 ITEVIR 0.0012
5593 Transferase Not Available 0.0012
5588 Cell division protein FtsY TM_0570 0.0012
5591 Complement component C8 gamma chain C8G 0.0012
5587 Iron(III)-binding periplasmic protein fbpA 0.0012
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0012
5582 Regulator of transcription; stringent starvation protein A sspA 0.0012
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0012
5581 Beta-fructosidase bfrA 0.0012
5600 Pyruvate decarboxylase pdc 0.0012
4375 Glutamine synthetase 1 glnA1 0.0012
5575 Short tail fiber protein 12 0.0012
5580 Hexon protein PII 0.0012
5574 Invasin YPTB1668 0.0012
694 Matrix protein 2 M 0.0012
625 Glutamate carboxypeptidase 2 FOLH1 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
292 Activin receptor type-1 ACVR1 0.0012
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0012
849 Activated CDC42 kinase 1 TNK2 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0012
3808 Dihydropteroate synthase 2 folP2 0.0012
3601 Dihydropteroate synthase 1 folP1 0.0012
3807 Dihydropteroate synthase 1 folP1 0.0012
2417 Chloramphenicol acetyltransferase cat 0.0012
3278 Chloramphenicol acetyltransferase cat 0.0012
6859 Protein S100-A4 S100A4 0.0012
2810 Dr hemagglutinin structural subunit draA 0.0012
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0012
4031 Glutathione S-transferase A1 GSTA1 0.0012
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0012
1275 Estrogen sulfotransferase SULT1E1 0.0012
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0011
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0011
5 Glutaminase liver isoform, mitochondrial GLS2 0.0011
917 Glutaminase kidney isoform, mitochondrial GLS 0.0011
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0011
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0011
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0011
5261 Phosphoribosylformylglycinamidine synthase purL 0.0011
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0011
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
714 Glutathione reductase, mitochondrial GSR 0.0011
916 Metabotropic glutamate receptor 1 GRM1 0.0011
665 Phosphoserine aminotransferase PSAT1 0.0011
4652 Phosphoserine aminotransferase serC 0.0011
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0011
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0011
581 Cytochrome P450 2R1 CYP2R1 0.0011
420 Glutamate decarboxylase 1 GAD1 0.0011
3900 Glutamate decarboxylase 1 GAD1 0.0011
3913 Glutamic acid decarboxylase GAD65 0.0011
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.0011
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0011
2300 Lysozyme E 0.0011
3633 Lysozyme R 0.0011
5597 Lysozyme 17 0.0011
3132 Tryptophan synthase alpha chain trpA 0.0011
6568 Tryptophan synthase alpha chain trpA 0.0011
923 Glutamate receptor 3 GRIA3 0.0011
5934 Cytochrome P450 26A1 CYP26A1 0.0011
5006 RNASE4 protein RNASE4 0.0011
2555 Pol polyprotein pol 0.0011
3242 Pol polyprotein gag-pol 0.0011
3471 Pol polyprotein gag-pro-pol 0.0011
5256 Pol polyprotein pol 0.0011
6469 Pol polyprotein gag-pol 0.0011
6565 Pol polyprotein Not Available 0.0011
232 Corticosteroid-binding globulin SERPINA6 0.0011
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0011
5328 Prostaglandin F synthase Tb11.02.2310 0.0011
4533 Glyoxalase family protein BC_1747 0.0011
3729 Citrate synthase gltA 0.0011
4575 Citrate synthase cit 0.0011
4580 Citrate synthase gltA 0.0011
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0011
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0011
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0011
448 Vitamin K-dependent gamma-carboxylase GGCX 0.001
1671 Excitatory amino acid transporter 3 SLC1A1 0.001
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.001
1992 Vitamin D-binding protein GC 0.001
144 Hemoglobin subunit alpha HBA1 0.001
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.001
3877 Growth-inhibiting protein 18 GIG18 0.001
426 Aspartate aminotransferase, mitochondrial GOT2 0.001
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.001
1483 Membrane copper amine oxidase AOC3 0.001
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.001
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.001
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.001
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.001
215 Sodium channel protein type 11 subunit alpha SCN11A 0.001
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.001
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.001
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.001
2603 Beta-lactamase II blm 0.001
763 Tyrosine aminotransferase TAT 0.001
5493 Tyrosine aminotransferase Not Available 0.001
2521 Cell division protein ftsZ ftsZ 0.001
3301 Cell division protein ftsZ ftsZ 0.001
2149 Angiogenin ANG 0.001
740 Argininosuccinate synthase ASS1 0.001
865 Argininosuccinate synthase ASS1 0.001
2680 Argininosuccinate synthase argG 0.001
3194 Argininosuccinate synthase argG 0.001
586 Aspartate aminotransferase, cytoplasmic GOT1 0.001
3583 6-phosphogluconolactonase pgl 0.001
857 Malate dehydrogenase, mitochondrial MDH2 0.001
65 Matrix metalloproteinase-9 Not Available 0.001
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.001
1256 5-hydroxytryptamine 6 receptor HTR6 0.001
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.001
661 ADP/ATP translocase 1 SLC25A4 0.0009
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0009
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0009
2942 Sialidase nanH 0.0009
3546 Sialidase nedA 0.0009
3486 Fumarate hydratase class II fumC 0.0009
3611 Cytidine deaminase cdd 0.0009
3707 Cytidine deaminase cdd 0.0009
4211 Cytidine deaminase CDA 0.0009
332 Beta-lactamase blaZ 0.0009
2478 Beta-lactamase ampC 0.0009
2613 Beta-lactamase ampC 0.0009
2635 Beta-lactamase ampC 0.0009
2700 Beta-lactamase penP 0.0009
5445 Beta-lactamase blaB 0.0009
6019 Beta-lactamase SHV-7 0.0009
6701 Beta-lactamase cphA 0.0009
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
2452 Tryptophanyl-tRNA synthetase trpS 0.0009
2697 Uridine-cytidine kinase 2 UCK2 0.0009
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.0009
1525 Heparin-binding growth factor 2 FGF2 0.0009
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0009
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.0009
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0009
705 Glutamate receptor 1 GRIA1 0.0009
3426 Glutamine synthetase glnA 0.0009
3987 Glutamine synthetase GLUL 0.0009
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0009
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0009
411 Glycine N-methyltransferase GNMT 0.0009
54 Prothrombin F2 0.0009
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0008
5579 Carboxypeptidase B CPB1 0.0008
719 Retinoic acid receptor responder protein 1 RARRES1 0.0008
770 Retinoic acid-induced protein 3 GPRC5A 0.0008
268 Adenosine A2b receptor ADORA2B 0.0008
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0008
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0008
3384 Macrophage migration inhibitory factor MIF 0.0008
856 Vitamin D3 receptor VDR 0.0008
295 Carbonic anhydrase 1 CA1 0.0008
459 Retinoic acid receptor RXR-alpha RXRA 0.0007
267 Plasminogen activator inhibitor 1 SERPINE1 0.0007
569 Retinal dehydrogenase 2 ALDH1A2 0.0007
163 D(1B) dopamine receptor DRD5 0.0007
611 Retinal dehydrogenase 1 ALDH1A1 0.0007
6221 Steroid hormone receptor ERR1 ESRRA 0.0007
1374 Natriuretic peptides B NPPB 0.0006
1827 Gap junction alpha-1 protein GJA1 0.0006
1908 Vascular cell adhesion protein 1 VCAM1 0.0006
164 Histamine H4 receptor HRH4 0.0006
5682 Ribonuclease pancreatic RNASE1 0.0006
822 Aldose reductase AKR1B1 0.0006
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0006
3937 Fatty-acid amide hydrolase FAAH 0.0006
3221 Cytochrome c4 cc4 0.0006
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0005
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0005
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0005
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0005
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0005
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0004
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0004
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0004
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0004
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0004
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
1360 Sphingomyelin phosphodiesterase SMPD1 0.0004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0004
2802 Endoglucanase G celCCG 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
444 Alcohol dehydrogenase 1B ADH1B 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0003
4954 Soluble cytochrome b558 Not Available 0.0002
4947 Bacterial hemoglobin vhb 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0002
4916 Cyanoglobin glbN 0.0002
4915 Cytochrome c-550 psbV 0.0002
4959 Cytochrome c-550 psbV 0.0002
5216 Cytochrome c-550 psbV 0.0002
4925 Cytochrome c-type protein SHP shp 0.0002
4975 Cytochrome c-556 RPA3973 0.0002
4943 Cytochrome c6 petJ 0.0002
4934 Cytochrome c-551 nirM 0.0002
5218 Cytochrome c-551 nirM 0.0002
4961 Hemophore HasA hasA 0.0002
4905 Cytochrome c2 Not Available 0.0002
4939 Cytochrome c2 cycA 0.0002
4964 Cytochrome c2 cycA 0.0002
4979 Cytochrome c2 cycA 0.0002
6673 Cytochrome c2 cycA 0.0002
4904 Cytochrome c family protein GSU1996 0.0002
4909 CooA protein cooA 0.0002
4994 Hemoglobin-like protein HbO glbO 0.0002
5000 HemO hemO 0.0002
4998 Hemoglobin-like protein yjbI yjbI 0.0002
644 Heme oxygenase 2 HMOX2 0.0002
4982 Heme oxygenase 2 pbsA2 0.0002
4942 Diheme cytochrome c napB napB 0.0002
4984 Neuroglobin NGB 0.0002
4935 Cytochrome c-554 cycA1 0.0002
4999 Cytochrome P450 165B3 CYP165B3 0.0002
4937 Cytochrome oxidase subunit II rcoxA 0.0002
4971 Nonaheme cytochrome c hmcA 0.0002
4989 Cytochrome c551 peroxidase ccp 0.0002
5222 Cytochrome c551 peroxidase ccpA 0.0002
4910 Cytoglobin CYGB 0.0002
4976 Apocytochrome f petA 0.0002
6407 Apocytochrome f petA 0.0002
4907 Cytochrome c-L moxG 0.0002
6865 Cytochrome c-L moxG 0.0002
4981 Iron-starvation protein PigA pigA 0.0002
4764 Cytochrome P450 165C4 CYP165C4 0.0002
4960 Putative cytochrome P450-family protein SCO7417 0.0002
4931 Cytochrome P450 167A1 CYP167A1 0.0002
4922 Cytochrome c, putative SO_4144 0.0002
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0002
4926 Heme-based aerotactic transducer hemAT hemAT 0.0002
4993 Hydroxylamine oxidoreductase hao1 0.0002
4903 Methyl-accepting chemotaxis protein Tar4 0.0002
4972 P450cin cinA 0.0002
3093 Catalase HPII katE 0.0002
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0002
4952 Catalase/peroxidase katA 0.0002
4920 Peroxidase/catalase katG 0.0002
2119 Cytochrome b5 CYB5A 0.0002
4948 Cytochrome c-553 Not Available 0.0002
4923 Cytochrome c3 DvMF_2499 0.0002
4945 Cytochrome c3 Not Available 0.0002
4949 Cytochrome c3 DVU_3171 0.0002
4968 Cytochrome c3 cytc3 0.0002
4997 Cytochrome c3 SO_2727 0.0002
5219 Cytochrome c3 cyd 0.0002
4902 Nine-heme cytochrome c Ddes_2038 0.0002
3189 High-molecular-weight cytochrome c hmcA 0.0002
4990 PpcA ppcA 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
2230 Catalase CAT 0.0002
3249 Catalase katA 0.0002
3625 Catalase katA 0.0002
4539 Catalase katA 0.0002
4941 Catalase katB 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0.0001
1507 Cytochrome c CYCS 0.0001
693 Hemoglobin subunit beta HBB 0.0001
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
2298 Cytochrome P450-cam camC 0.0001
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