DT-Web

DB03581 - Glucose-6-Phosphate


Identification
Name Glucose-6-Phosphate
Accession Number DB03581 (EXPT01538)
Type small molecule
Description An ester of glucose with phosphoric acid, made in the course of glucose metabolism by mammalian and other cells. It is a normal constituent of resting muscle and probably is in constant equilibrium with fructose-6-phosphate. (Stedman, 26th ed)
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 260.1358
Groups experimental
Monoisotopic Weight 260.029718526
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]
Name Glucosamine--fructose-6-phosphate aminotransferase [isomerizing]
Gene Name glmS
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.909
Glucose-6-phosphate isomerase
Name Glucose-6-phosphate isomerase
Gene Name GPI
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.1099

Transporters


Solute carrier organic anion transporter family member 2A1
Name Solute carrier organic anion transporter family member 2A1
Gene Name SLCO2A1
Actions inhibitor
References
  • Chan BS, Endo S, Kanai N, Schuster VL: Identification of lactate as a driving force for prostanoid transport by prostaglandin transporter PGT. Am J Physiol Renal Physiol. 2002 Jun;282(6):F1097-102. - Pubmed
DTHybrid score 0.3408

Predictions


Id Partner name Gene Name Score
3072 N-acetylglucosamine-6-phosphate deacetylase nagA 0.203
2677 Glucose-6-phosphate isomerase B pgiB 0.1405
3134 Phospho-2-dehydro-3-deoxyheptonate aldolase aroF 0.1151
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.1088
2949 Glucosamine-6-phosphate deaminase nagB 0.1086
2621 Thermoresistant gluconokinase gntK 0.0937
2310 2-dehydro-3-deoxyphosphooctonate aldolase kdsA 0.0872
2542 2-dehydro-3-deoxyphosphooctonate aldolase kdsA 0.0872
2538 6-phospho-beta-glucosidase bglT bglT 0.0705
2393 Maltose-6'-phosphate glucosidase glvA 0.0705
2439 Alpha,alpha-trehalose-phosphate synthase [UDP-forming] otsA 0.0613
1881 Hexokinase-1 HK1 0.0613
2503 Phosphomannomutase/phosphoglucomutase algC 0.0587
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0582
6433 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 PFKFB4 0.0562
3309 6-phosphofructokinase pfkA 0.0561
52 Pyruvate kinase isozymes R/L PKLR 0.0518
2922 Glycerol kinase glpK 0.0504
1750 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 PFKFB1 0.0468
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0466
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0425
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0425
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0425
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0425
4198 Fructose-1,6-bisphosphatase 1 FBP1 0.0404
822 Aldose reductase AKR1B1 0.0402
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0375
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0373
1152 Glycogen phosphorylase, muscle form PYGM 0.0367
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0307
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0288
527 Prostacyclin receptor PTGIR 0.0233
2853 14 kDa fatty acid-binding protein Not Available 0.0219
5650 NimA-related protein DR_0842 0.0218
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0218
3676 Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive aroG 0.0216
4384 Capsule biosynthesis protein synC 0.0199
489 Monocarboxylate transporter 2 SLC16A7 0.0194
500 Monocarboxylate transporter 4 SLC16A3 0.0193
1116 Phosphoenolpyruvate carboxykinase, cytosolic [GTP] PCK1 0.0188
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0175
1024 Solute carrier family 22 member 11 SLC22A11 0.0173
6085 Fatty acid-binding protein, intestinal FABP2 0.0156
738 Monocarboxylate transporter 1 SLC16A1 0.0155
6142 Solute carrier family 22 member 8 SLC22A8 0.0152
2183 Fatty acid-binding protein, adipocyte FABP4 0.015
6136 Multidrug resistance-associated protein 5 ABCC5 0.0147
6151 Monocarboxylate transporter 10 SLC16A10 0.0138
1729 Solute carrier family 22 member 6 SLC22A6 0.0137
587 Serum albumin ALB 0.0132
2164 Multidrug resistance-associated protein 4 ABCC4 0.0123
672 Prostaglandin F2-alpha receptor PTGFR 0.0123
1792 Tissue-type plasminogen activator PLAT 0.0116
5446 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase HI_1679 0.0113
3781 Thiol:disulfide interchange protein dsbC precursor dsbC 0.0113
5449 Hypothetical gliding protein mglB 0.0113
5443 UPF0189 protein ymdB ymdB 0.0113
5439 33 kDa chaperonin hslO 0.0113
4705 Manganese catalase Not Available 0.0113
332 Beta-lactamase blaZ 0.0113
2478 Beta-lactamase ampC 0.0113
2613 Beta-lactamase ampC 0.0113
2635 Beta-lactamase ampC 0.0113
2700 Beta-lactamase penP 0.0113
5445 Beta-lactamase blaB 0.0113
6019 Beta-lactamase SHV-7 0.0113
6701 Beta-lactamase cphA 0.0113
5448 Ribonuclease Z rnz 0.0113
5440 UPF0067 protein yebR yebR 0.0113
2720 Copper-containing nitrite reductase nirK 0.0113
5447 Lethal(3)malignant brain tumor-like protein L3MBTL1 0.0113
5454 Internalin-A inlA 0.0113
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.0104
6143 Solute carrier family 22 member 7 SLC22A7 0.0103
2714 Chorismate mutase aroH 0.0098
4611 Chorismate mutase aroG 0.0098
4771 Dissimilatory copper-containing nitrite reductase nir 0.0098
3274 Hydroxylamine reductase hcp 0.0098
4804 Hydroxylamine reductase hcp 0.0098
4498 Ornithine cyclodeaminase PP3533 0.0098
3356 Diaminopimelate decarboxylase lysA 0.0098
5450 Prolyl endopeptidase Pep pep 0.0098
6144 Solute carrier family 22 member 2 SLC22A2 0.0093
3399 Limonene-1,2-epoxide hydrolase limA 0.0091
3462 Tyrosine-protein kinase transforming protein Abl ABL 0.0091
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.0091
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.009
218 Monocarboxylate transporter 5 SLC16A4 0.0088
195 Monocarboxylate transporter 7 SLC16A6 0.0088
397 Monocarboxylate transporter 3 SLC16A8 0.0088
429 Monocarboxylate transporter 6 SLC16A5 0.0088
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0087
5180 L(+)-mandelate dehydrogenase mdlB 0.0085
3500 Putative family 31 glucosidase yicI yicI 0.0085
558 Solute carrier family 12 member 1 SLC12A1 0.0084
20 Prostaglandin G/H synthase 1 PTGS1 0.0083
1615 Chymase CMA1 0.0082
4608 Putative cytochrome P450 SCO1207 0.0082
4963 Putative cytochrome P450 SCO2884 0.0082
6254 Putative cytochrome P450 SCO6998 0.0082
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.008
597 Dihydropteridine reductase QDPR 0.008
4757 Cytochrome P450 2C9 CYP2C9 0.008
577 Argininosuccinate lyase ASL 0.0079
3480 Mannan endo-1,4-beta-mannosidase manA 0.0079
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0079
365 Dihydrofolate reductase DHFR 0.0076
2381 Dihydrofolate reductase DFR1 0.0076
2833 Dihydrofolate reductase Not Available 0.0076
2931 Dihydrofolate reductase folA 0.0076
3544 Dihydrofolate reductase folA 0.0076
3682 Dihydrofolate reductase folA 0.0076
6642 Dihydrofolate reductase folA 0.0076
6756 Dihydrofolate reductase dfrA 0.0076
771 Pyruvate carboxylase, mitochondrial PC 0.0076
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0075
287 Beta-1,4-galactosyltransferase 1 B4GALT1 0.0074
98 Pyruvate kinase isozymes M1/M2 PKM2 0.0074
357 Carbonic anhydrase 2 CA2 0.0067
114 Alanine--glyoxylate aminotransferase 2, mitochondrial AGXT2 0.0066
118 Organic cation/carnitine transporter 2 SLC22A5 0.0063
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0061
199 Monocarboxylate transporter 8 SLC16A2 0.006
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0059
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0053
904 Glutathione S-transferase P GSTP1 0.0051
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0049
6167 Organic solute transporter subunit beta OSTB 0.0047
6166 Organic solute transporter subunit alpha OSTA 0.0047
474 Acetylcholinesterase ACHE 0.0044
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0037
3923 Cholinesterase BCHE 0.0035
4200 Cytochrome P450 1A2 CYP1A2 0.0035
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0034
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0033
468 Cytochrome P450 4A11 CYP4A11 0.0028
3811 Cytochrome P450 19A1 CYP19A1 0.0028
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0027
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0026
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0026
921 Glutamate receptor 2 GRIA2 0.0025
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0025
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0025
6145 Solute carrier family 22 member 1 SLC22A1 0.0025
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0024
6106 Cytochrome P450 2C18 CYP2C18 0.0024
776 Bile salt export pump ABCB11 0.0023
1898 Cytochrome P450 1B1 CYP1B1 0.0023
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0022
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0022
862 Multidrug resistance-associated protein 1 ABCC1 0.0021
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0021
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0021
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0021
5718 Cytochrome P450 2A6 CYP2A6 0.002
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.002
6024 Cytochrome P450 1A1 CYP1A1 0.0019
6030 Cytochrome P450 2B6 CYP2B6 0.0018
6013 Cytochrome P450 2E1 CYP2E1 0.0018
6107 Cytochrome P450 3A7 CYP3A7 0.0017
4118 Cytochrome P450 3A5 CYP3A5 0.0017
4924 Cytochrome P450 2C8 CYP2C8 0.0016
6016 Cytochrome P450 2C19 CYP2C19 0.0016
1588 Multidrug resistance protein 1 ABCB1 0.0015
4512 Cytochrome P450 3A4 CYP3A4 0.0013
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