DT-Web

DB03314 - Fluorotryptophane


Identification
Name Fluorotryptophane
Accession Number DB03314 (EXPT01505)
Type small molecule
Description Fluorotryptophane can be used as substrate analogue to study enzyme mechanisms by NMR spectroscopy.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 222.2156
Groups experimental
Monoisotopic Weight 222.080455811
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Triosephosphate isomerase
Name Triosephosphate isomerase
Gene Name TPI1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.0561
Glutathione S-transferase Mu 1
Name Glutathione S-transferase Mu 1
Gene Name GSTM1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.6094

Predictions


Id Partner name Gene Name Score
2914 Triosephosphate isomerase, glycosomal Not Available 0.103
3705 L-fuculose phosphate aldolase fucA 0.1016
2165 Glutathione S-transferase Mu 2 GSTM2 0.0874
904 Glutathione S-transferase P GSTP1 0.0858
3069 Fructose-bisphosphate aldolase A ALDOA 0.059
2926 Bifunctional PGK/TIM [Includes: Phosphoglycerate kinase pgk/tpi 0.0587
2314 Triosephosphate isomerase TPI 0.0561
3417 Triosephosphate isomerase tpiA 0.0561
3443 Triosephosphate isomerase tpiA 0.0561
2262 2,3-bisphosphoglycerate-independent phosphoglycerate mutase gpmI 0.0508
3467 Methylglyoxal synthase mgsA 0.0483
4031 Glutathione S-transferase A1 GSTA1 0.0431
3419 Rhamnulose-1-phosphate aldolase rhaD 0.0389
3727 Tagatose-1,6-bisphosphate aldolase agaY kbaY 0.0389
3693 Fructose-bisphosphate aldolase class 2 fbaA 0.0389
3932 Glutathione S-transferase A2 GSTA2 0.0383
2392 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0326
3032 Biphenyl-2,3-diol 1,2-dioxygenase bphC 0.0326
4041 Microsomal glutathione S-transferase 2 MGST2 0.0274
2795 Methionine aminopeptidase 2 METAP2 0.0262
3947 Xanthine dehydrogenase/oxidase XDH 0.0253
5682 Ribonuclease pancreatic RNASE1 0.0233
908 Glutathione S-transferase theta-1 GSTT1 0.023
6163 Copper-transporting ATPase 2 ATP7B 0.0224
6165 Copper-transporting ATPase 1 ATP7A 0.0224
2904 Phosphatase yniC yniC 0.0212
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0211
6146 High affinity copper uptake protein 1 SLC31A1 0.021
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0193
465 Calmodulin CALM1 0.0187
3309 6-phosphofructokinase pfkA 0.0185
3676 Phospho-2-dehydro-3-deoxyheptonate aldolase, Phe-sensitive aroG 0.0185
3192 Glucosamine-6-phosphate deaminase 1 nagB 0.0185
1405 Thiopurine S-methyltransferase TPMT 0.0181
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.018
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0166
1757 Myeloperoxidase MPO 0.016
52 Pyruvate kinase isozymes R/L PKLR 0.0149
98 Pyruvate kinase isozymes M1/M2 PKM2 0.0139
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0134
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0119
909 Maleylacetoacetate isomerase GSTZ1 0.0111
5670 Organic hydroperoxide resistance protein ohr 0.0106
5669 50S ribosomal protein L27 rpmA 0.0106
5675 Chaperone protein torD torD 0.0106
5672 Molybdenum cofactor biosynthesis protein A moaA 0.0106
5410 Unsaturated glucuronyl hydrolase ugl 0.0106
5676 Axin-1 AXIN1 0.0106
5673 C protein alpha-antigen bca 0.0106
3317 Holo-[acyl-carrier-protein] synthase acpS 0.0092
4381 Holo-[acyl-carrier-protein] synthase acpS 0.0092
2636 Shikimate dehydrogenase aroE 0.0092
3515 Shikimate dehydrogenase aroE 0.0092
3125 Protease synthase and sporulation negative regulatory protein PAI 1 paiA 0.0092
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0092
2280 Listeriolysin regulatory protein prfA 0.0085
6579 Calcium/calmodulin-dependent protein kinase type II alpha chain CAMK2A 0.0085
4811 Amylosucrase ams 0.0085
3191 Histidinol dehydrogenase hisD 0.008
4512 Cytochrome P450 3A4 CYP3A4 0.0077
191 Peptide methionine sulfoxide reductase MSRA 0.0076
4084 Peptidyl-prolyl cis-trans isomerase B PPIB 0.0075
6144 Solute carrier family 22 member 2 SLC22A2 0.0069
6136 Multidrug resistance-associated protein 5 ABCC5 0.006
611 Retinal dehydrogenase 1 ALDH1A1 0.0058
24 Thymidylate synthase TMP1 0.0057
359 Thymidylate synthase TYMS 0.0057
2626 Thymidylate synthase thyA 0.0057
2729 Thymidylate synthase thyA 0.0057
5352 Thymidylate synthase THYA 0.0057
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0054
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0049
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0049
4035 Glutathione S-transferase Mu 5 GSTM5 0.0046
6147 Solute carrier family 22 member 3 SLC22A3 0.0045
1898 Cytochrome P450 1B1 CYP1B1 0.0044
468 Cytochrome P450 4A11 CYP4A11 0.0042
6137 Multidrug resistance-associated protein 6 ABCC6 0.0042
900 Glutathione S-transferase A4 GSTA4 0.0039
1928 Leukotriene C4 synthase LTC4S 0.0039
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0039
903 Glutathione S-transferase A5 GSTA5 0.0039
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0039
4034 Glutaredoxin-1 GLRX 0.0039
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0039
4036 Glutathione peroxidase 6 GPX6 0.0039
4040 Glutathione peroxidase 7 GPX7 0.0039
4037 Hypothetical protein GPX1 0.0039
4297 Hypothetical protein SP_1951 0.0039
4521 Hypothetical protein BC_2969 0.0039
4540 Hypothetical protein TM_1070 0.0039
4555 Hypothetical protein MT1739 0.0039
4569 Hypothetical protein mshD 0.0039
4578 Hypothetical protein PA3270 0.0039
4747 Hypothetical protein PA3967 0.0039
5177 Hypothetical protein TM_0096 0.0039
5194 Hypothetical protein PA1204 0.0039
5240 Hypothetical protein Rv2991 0.0039
5370 Hypothetical protein TM_1158 0.0039
5710 Hypothetical protein Tb927.5.1360 0.0039
4029 Microsomal glutathione S-transferase 3 MGST3 0.0039
4032 Microsomal glutathione S-transferase 1 MGST1 0.0039
4033 S-formylglutathione hydrolase ESD 0.0039
907 Glutathione peroxidase 2 GPX2 0.0039
4038 Glutathione peroxidase 4 GPX4 0.0039
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0039
906 Glutathione peroxidase 1 GPX1 0.0039
910 Epididymal secretory glutathione peroxidase GPX5 0.0039
911 Glutathione peroxidase 3 GPX3 0.0039
4042 Glutathione transferase omega-2 GSTO2 0.0039
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0039
6145 Solute carrier family 22 member 1 SLC22A1 0.0038
897 Glutathione S-transferase kappa 1 GSTK1 0.0036
898 Glutathione S-transferase A3 GSTA3 0.0036
3319 Hydroxyacylglutathione hydrolase HAGH 0.0036
6024 Cytochrome P450 1A1 CYP1A1 0.0036
901 Glutathione S-transferase Mu 4 GSTM4 0.0035
899 Glutathione S-transferase Mu 3 GSTM3 0.0035
6013 Cytochrome P450 2E1 CYP2E1 0.0034
905 Glutathione transferase omega-1 GSTO1 0.0032
3923 Cholinesterase BCHE 0.0032
290 Prostaglandin G/H synthase 2 PTGS2 0.0031
4200 Cytochrome P450 1A2 CYP1A2 0.003
207 Glutathione synthetase GSS 0.0029
5269 Glutathione synthetase gshB 0.0029
1313 Lactoylglutathione lyase GLO1 0.0028
6030 Cytochrome P450 2B6 CYP2B6 0.0027
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0027
714 Glutathione reductase, mitochondrial GSR 0.0025
1588 Multidrug resistance protein 1 ABCB1 0.0023
4757 Cytochrome P450 2C9 CYP2C9 0.0023
2164 Multidrug resistance-associated protein 4 ABCC4 0.0017
862 Multidrug resistance-associated protein 1 ABCC1 0.0016
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