DT-Web

DB00709 - Lamivudine


Identification
Name Lamivudine
Accession Number DB00709 (APRD00681)
Type small molecule
Description A reverse transcriptase inhibitor and zalcitabine analog in which a sulfur atom replaces the 3' carbon of the pentose ring. It is used to treat Human Immunodeficiency Virus Type 1 (HIV-1) and hepatitis B (HBV).
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 229.256
Groups approved
Monoisotopic Weight 229.052111923
Pharmacology
Indication For the treatment of HIV infection and chronic hepatitis B (HBV).
Mechanism of action Lamivudine is a synthetic nucleoside analogue and is phosphorylated intracellularly to its active 5'-triphosphate metabolite, lamivudine triphosphate (L-TP). This nucleoside analogue is incorporated into viral DNA by HIV reverse transcriptase and HBV polymerase, resulting in DNA chain termination.
Absorption Lamivudine was rapidly absorbed after oral administration in HIV-infected patients. Absolute bioavailability in 12 adult patients was 86% ? 16% (mean ? SD) for the 150-mg tablet and 87% ? 13% for the oral solution. The peak serum lamivudine concentration (Cmax) was 1.5 ? 0.5 mcg/mL when an oral dose of 2 mg/kg twice a day was given to HIV-1 patients. When given with food, absorption is slower, compared to the fasted state.
Protein binding <36% bound to plasma protein.
Biotransformation Metabolism of lamivudine is a minor route of elimination. In man, the only known metabolite of lamivudine is the trans-sulfoxide metabolite. This biotransformation is catalyzed by sulfotransferases.
Route of elimination The majority of lamivudine is eliminated unchanged in urine by active organic cationic secretion. 5.2% ? 1.4% (mean ? SD) of the dose was excreted as the trans-sulfoxide metabolite in the urine. Lamivudine is excreted in human breast milk and into the milk of lactating rats.
Toxicity The most common reported adverse reactions (incidence >=15%) in adults were headache, nausea, malaise and fatigue, nasal signs and symptoms, diarrhea, and cough.
Affected organisms
  • Hepatitis B virus
  • Human Immunodeficiency Virus
Interactions
Drug Interactions
Drug Mechanism of interaction
Tobramycin Increased risk of nephrotoxicity
Valganciclovir The adverse/toxic effects of reverse transcriptase inhibitors (nucleoside), such as Lamivudine, may be enhanced by Valganciclovir. There is a risk of hematologic toxicity. Diligent monitoring during concomitant therapy is recommended.
Zalcitabine Lamivudine may reduce the efficacy of zalcitabine. Combination therapy is not recommended.
Food Interactions
  • Take without regard to meals. Food does not decrease the extent of absorption, but it decreases the Cmax by slowing the rate of absorption.

Targets


Reverse transcriptase
Name Reverse transcriptase
Gene Name Not Available
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score Not Available
DNA
Name DNA
Gene Name Not Available
Pharmacological action yes
Actions adduct
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Pan XP, Li LJ, Du WB, Li MW, Cao HC, Sheng JF: Differences of YMDD mutational patterns, precore/core promoter mutations, serum HBV DNA levels in lamivudine-resistant hepatitis B genotypes B and C. J Viral Hepat. 2007 Nov;14(11):767-74. - Pubmed
  • Dai CY, Yu ML, Hsieh MY, Lee LP, Hou NJ, Huang JF, Chen SC, Lin ZY, Hsieh MY, Wang LY, Tsai JF, Chang WY, Chuang WL: Early response to lamivudine therapy in clinically non-cirrhotic chronic hepatitis B patients with decompensation. Liver Int. 2007 Sep 27;. - Pubmed
  • Ma H, Guo F, Wei L, Sun Y, Wang H: [The prospective study of the clinical features and outcome of HBeAg-negative and HBeAg-positive cirrhosis in patients with chronic type B hepatitis] Zhonghua Yi Xue Za Zhi. 2007 Jul 10;87(26):1832-5. - Pubmed
DTHybrid score Not Available
P protein [Includes: DNA-directed DNA polymerase
Name P protein [Includes: DNA-directed DNA polymerase
Gene Name P
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Stuyver LJ, Locarnini SA, Lok A, Richman DD, Carman WF, Dienstag JL, Schinazi RF: Nomenclature for antiviral-resistant human hepatitis B virus mutations in the polymerase region. Hepatology. 2001 Mar;33(3):751-7. - Pubmed
DTHybrid score 0.0902

Enzymes


Deoxycytidine kinase
Name Deoxycytidine kinase
Gene Name DCK
Actions substrate
References
  • Hunsucker SA, Mitchell BS, Spychala J: The 5'-nucleotidases as regulators of nucleotide and drug metabolism. Pharmacol Ther. 2005 Jul;107(1):1-30. - Pubmed
  • Cihlar T, Ray AS: Nucleoside and nucleotide HIV reverse transcriptase inhibitors: 25 years after zidovudine. Antiviral Res. 2010 Jan;85(1):39-58. doi: 10.1016/j.antiviral.2009.09.014. Epub 2009 Nov 1. - Pubmed
DTHybrid score 0.5924
UMP-CMP kinase
Name UMP-CMP kinase
Gene Name CMPK1
Actions substrate
References
  • Hunsucker SA, Mitchell BS, Spychala J: The 5'-nucleotidases as regulators of nucleotide and drug metabolism. Pharmacol Ther. 2005 Jul;107(1):1-30. - Pubmed
  • Cihlar T, Ray AS: Nucleoside and nucleotide HIV reverse transcriptase inhibitors: 25 years after zidovudine. Antiviral Res. 2010 Jan;85(1):39-58. doi: 10.1016/j.antiviral.2009.09.014. Epub 2009 Nov 1. - Pubmed
DTHybrid score 0.5335
Phosphoglycerate kinase 1
Name Phosphoglycerate kinase 1
Gene Name PGK1
Actions substrate
References
  • Hunsucker SA, Mitchell BS, Spychala J: The 5'-nucleotidases as regulators of nucleotide and drug metabolism. Pharmacol Ther. 2005 Jul;107(1):1-30. - Pubmed
  • Cihlar T, Ray AS: Nucleoside and nucleotide HIV reverse transcriptase inhibitors: 25 years after zidovudine. Antiviral Res. 2010 Jan;85(1):39-58. doi: 10.1016/j.antiviral.2009.09.014. Epub 2009 Nov 1. - Pubmed
DTHybrid score Not Available
Nucleoside diphosphate kinase A
Name Nucleoside diphosphate kinase A
Gene Name NME1
Actions substrate
References
  • Hunsucker SA, Mitchell BS, Spychala J: The 5'-nucleotidases as regulators of nucleotide and drug metabolism. Pharmacol Ther. 2005 Jul;107(1):1-30. - Pubmed
  • Cihlar T, Ray AS: Nucleoside and nucleotide HIV reverse transcriptase inhibitors: 25 years after zidovudine. Antiviral Res. 2010 Jan;85(1):39-58. doi: 10.1016/j.antiviral.2009.09.014. Epub 2009 Nov 1. - Pubmed
DTHybrid score 1.2665
Nucleoside diphosphate kinase B
Name Nucleoside diphosphate kinase B
Gene Name NME2
Actions substrate
References
  • Hunsucker SA, Mitchell BS, Spychala J: The 5'-nucleotidases as regulators of nucleotide and drug metabolism. Pharmacol Ther. 2005 Jul;107(1):1-30. - Pubmed
  • Cihlar T, Ray AS: Nucleoside and nucleotide HIV reverse transcriptase inhibitors: 25 years after zidovudine. Antiviral Res. 2010 Jan;85(1):39-58. doi: 10.1016/j.antiviral.2009.09.014. Epub 2009 Nov 1. - Pubmed
DTHybrid score 0.3163
Choline-phosphate cytidylyltransferase A
Name Choline-phosphate cytidylyltransferase A
Gene Name PCYT1A
Actions substrate
References
  • Zhou Z, Rodman JH, Flynn PM, Robbins BL, Wilcox CK, D'Argenio DZ: Model for intracellular Lamivudine metabolism in peripheral blood mononuclear cells ex vivo and in human immunodeficiency virus type 1-infected adolescents. Antimicrob Agents Chemother. 2006 Aug;50(8):2686-94. - Pubmed
  • KENNEDY EP, BORKENHAGEN LF, SMITH SW: Possible metabolic functions of deoxycytidine diphosphate choline and deoxycytidine diphosphate ethanolamine. J Biol Chem. 1959 Aug;234(8):1998-2000. - Pubmed
DTHybrid score 0.212
Ethanolamine-phosphate cytidylyltransferase
Name Ethanolamine-phosphate cytidylyltransferase
Gene Name Not Available
Actions substrate
References
  • Zhou Z, Rodman JH, Flynn PM, Robbins BL, Wilcox CK, D'Argenio DZ: Model for intracellular Lamivudine metabolism in peripheral blood mononuclear cells ex vivo and in human immunodeficiency virus type 1-infected adolescents. Antimicrob Agents Chemother. 2006 Aug;50(8):2686-94. - Pubmed
  • KENNEDY EP, BORKENHAGEN LF, SMITH SW: Possible metabolic functions of deoxycytidine diphosphate choline and deoxycytidine diphosphate ethanolamine. J Biol Chem. 1959 Aug;234(8):1998-2000. - Pubmed
DTHybrid score Not Available
5'(3')-deoxyribonucleotidase, cytosolic type
Name 5'(3')-deoxyribonucleotidase, cytosolic type
Gene Name Not Available
Actions substrate
References
  • Hunsucker SA, Mitchell BS, Spychala J: The 5'-nucleotidases as regulators of nucleotide and drug metabolism. Pharmacol Ther. 2005 Jul;107(1):1-30. - Pubmed
  • Cihlar T, Ray AS: Nucleoside and nucleotide HIV reverse transcriptase inhibitors: 25 years after zidovudine. Antiviral Res. 2010 Jan;85(1):39-58. doi: 10.1016/j.antiviral.2009.09.014. Epub 2009 Nov 1. - Pubmed
DTHybrid score Not Available

Transporters


Multidrug resistance-associated protein 1
Name Multidrug resistance-associated protein 1
Gene Name ABCC1
Actions inhibitor
References
  • Olson DP, Scadden DT, D'Aquila RT, De Pasquale MP: The protease inhibitor ritonavir inhibits the functional activity of the multidrug resistance related-protein 1 (MRP-1). AIDS. 2002 Sep 6;16(13):1743-7. - Pubmed
DTHybrid score 0.3494
Solute carrier family 22 member 6
Name Solute carrier family 22 member 6
Gene Name SLC22A6
Actions substrate
References
  • Wada S, Tsuda M, Sekine T, Cha SH, Kimura M, Kanai Y, Endou H: Rat multispecific organic anion transporter 1 (rOAT1) transports zidovudine, acyclovir, and other antiviral nucleoside analogs. J Pharmacol Exp Ther. 2000 Sep;294(3):844-9. - Pubmed
DTHybrid score 0.4448
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions substrate
References
  • Wang X, Furukawa T, Nitanda T, Okamoto M, Sugimoto Y, Akiyama S, Baba M: Breast cancer resistance protein (BCRP/ABCG2) induces cellular resistance to HIV-1 nucleoside reverse transcriptase inhibitors. Mol Pharmacol. 2003 Jan;63(1):65-72. - Pubmed
DTHybrid score 0.3955
Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions substrate
References
  • Minuesa G, Volk C, Molina-Arcas M, Gorboulev V, Erkizia I, Arndt P, Clotet B, Pastor-Anglada M, Koepsell H, Martinez-Picado J: Transport of lamivudine [(-)-beta-L-2',3'-dideoxy-3'-thiacytidine] and high-affinity interaction of nucleoside reverse transcriptase inhibitors with human organic cation transporters 1, 2, and 3. J Pharmacol Exp Ther. 2009 Apr;329(1):252-61. doi: 10.1124/jpet.108.146225. Epub 2009 Jan 13. - Pubmed
  • Errasti-Murugarren E, Pastor-Anglada M: Drug transporter pharmacogenetics in nucleoside-based therapies. Pharmacogenomics. 2010 Jun;11(6):809-41. doi: 10.2217/pgs.10.70. - Pubmed
DTHybrid score 0.4335
Solute carrier family 22 member 2
Name Solute carrier family 22 member 2
Gene Name SLC22A2
Actions substrate
References
  • Minuesa G, Volk C, Molina-Arcas M, Gorboulev V, Erkizia I, Arndt P, Clotet B, Pastor-Anglada M, Koepsell H, Martinez-Picado J: Transport of lamivudine [(-)-beta-L-2',3'-dideoxy-3'-thiacytidine] and high-affinity interaction of nucleoside reverse transcriptase inhibitors with human organic cation transporters 1, 2, and 3. J Pharmacol Exp Ther. 2009 Apr;329(1):252-61. doi: 10.1124/jpet.108.146225. Epub 2009 Jan 13. - Pubmed
  • Errasti-Murugarren E, Pastor-Anglada M: Drug transporter pharmacogenetics in nucleoside-based therapies. Pharmacogenomics. 2010 Jun;11(6):809-41. doi: 10.2217/pgs.10.70. - Pubmed
DTHybrid score 0.382
Solute carrier family 22 member 3
Name Solute carrier family 22 member 3
Gene Name SLC22A3
Actions substrate
References
  • Minuesa G, Volk C, Molina-Arcas M, Gorboulev V, Erkizia I, Arndt P, Clotet B, Pastor-Anglada M, Koepsell H, Martinez-Picado J: Transport of lamivudine [(-)-beta-L-2',3'-dideoxy-3'-thiacytidine] and high-affinity interaction of nucleoside reverse transcriptase inhibitors with human organic cation transporters 1, 2, and 3. J Pharmacol Exp Ther. 2009 Apr;329(1):252-61. doi: 10.1124/jpet.108.146225. Epub 2009 Jan 13. - Pubmed
  • Errasti-Murugarren E, Pastor-Anglada M: Drug transporter pharmacogenetics in nucleoside-based therapies. Pharmacogenomics. 2010 Jun;11(6):809-41. doi: 10.2217/pgs.10.70. - Pubmed
DTHybrid score 0.3369
Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions substrate
References
  • Errasti-Murugarren E, Pastor-Anglada M: Drug transporter pharmacogenetics in nucleoside-based therapies. Pharmacogenomics. 2010 Jun;11(6):809-41. doi: 10.2217/pgs.10.70. - Pubmed
DTHybrid score 0.5219
Multidrug resistance-associated protein 4
Name Multidrug resistance-associated protein 4
Gene Name ABCC4
Actions substrate
References
  • Errasti-Murugarren E, Pastor-Anglada M: Drug transporter pharmacogenetics in nucleoside-based therapies. Pharmacogenomics. 2010 Jun;11(6):809-41. doi: 10.2217/pgs.10.70. - Pubmed
DTHybrid score 0.3649
Canalicular multispecific organic anion transporter 2
Name Canalicular multispecific organic anion transporter 2
Gene Name ABCC3
Actions substrate
References
  • Errasti-Murugarren E, Pastor-Anglada M: Drug transporter pharmacogenetics in nucleoside-based therapies. Pharmacogenomics. 2010 Jun;11(6):809-41. doi: 10.2217/pgs.10.70. - Pubmed
DTHybrid score 0.2659
Canalicular multispecific organic anion transporter 1
Name Canalicular multispecific organic anion transporter 1
Gene Name ABCC2
Actions Not Available
References
  • Errasti-Murugarren E, Pastor-Anglada M: Drug transporter pharmacogenetics in nucleoside-based therapies. Pharmacogenomics. 2010 Jun;11(6):809-41. doi: 10.2217/pgs.10.70. - Pubmed
DTHybrid score 0.4193

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.2941
6142 Solute carrier family 22 member 8 SLC22A8 0.2196
4757 Cytochrome P450 2C9 CYP2C9 0.1909
4200 Cytochrome P450 1A2 CYP1A2 0.1793
4119 Cytochrome P450 2D6 CYP2D6 0.1711
4118 Cytochrome P450 3A5 CYP3A5 0.1648
4924 Cytochrome P450 2C8 CYP2C8 0.1516
6148 Multidrug resistance-associated protein 7 ABCC10 0.1506
118 Organic cation/carnitine transporter 2 SLC22A5 0.149
6016 Cytochrome P450 2C19 CYP2C19 0.1479
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.1377
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.1242
6107 Cytochrome P450 3A7 CYP3A7 0.1241
587 Serum albumin ALB 0.1224
603 DNA polymerase alpha catalytic subunit POLA1 0.118
6136 Multidrug resistance-associated protein 5 ABCC5 0.1156
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.1141
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.1135
776 Bile salt export pump ABCB11 0.1131
6143 Solute carrier family 22 member 7 SLC22A7 0.1031
833 Organic cation/carnitine transporter 1 SLC22A4 0.102
1024 Solute carrier family 22 member 11 SLC22A11 0.0973
3690 Class B acid phosphatase precursor aphA 0.0952
6030 Cytochrome P450 2B6 CYP2B6 0.0907
342 P protein [Includes: DNA-directed DNA polymerase P 0.0902
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0885
6024 Cytochrome P450 1A1 CYP1A1 0.0827
24 Thymidylate synthase TMP1 0.0825
359 Thymidylate synthase TYMS 0.0825
2626 Thymidylate synthase thyA 0.0825
2729 Thymidylate synthase thyA 0.0825
5352 Thymidylate synthase THYA 0.0825
6171 Solute carrier family 28 member 3 SLC28A3 0.0808
6013 Cytochrome P450 2E1 CYP2E1 0.0808
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0766
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0718
6137 Multidrug resistance-associated protein 6 ABCC6 0.0673
2633 Anaerobic ribonucleoside-triphosphate reductase NRDD 0.0662
20 Prostaglandin G/H synthase 1 PTGS1 0.0658
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0632
817 DNA topoisomerase 2-alpha TOP2A 0.0612
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.061
290 Prostaglandin G/H synthase 2 PTGS2 0.0608
3611 Cytidine deaminase cdd 0.0603
3707 Cytidine deaminase cdd 0.0603
4211 Cytidine deaminase CDA 0.0603
6141 Sodium/bile acid cotransporter SLC10A1 0.0602
1898 Cytochrome P450 1B1 CYP1B1 0.0576
2638 Formate dehydrogenase H fdhF 0.0571
5718 Cytochrome P450 2A6 CYP2A6 0.0554
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0547
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0514
6447 Guanine nucleotide-binding protein G(t) subunit alpha-1 GNAT1 0.051
3923 Cholinesterase BCHE 0.047
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0465
6083 Deoxyguanosine kinase, mitochondrial DGUOK 0.0461
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0457
2748 Cysteine desulfurase sufS 0.0433
861 Choline kinase alpha CHKA 0.0432
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0432
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0432
3927 Choline transporter-like protein 3 SLC44A3 0.0431
700 Choline dehydrogenase, mitochondrial CHDH 0.0431
1686 Choline transporter-like protein 1 SLC44A1 0.0431
3926 Choline transporter-like protein 2 SLC44A2 0.0431
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0431
3925 Choline transporter-like protein 4 SLC44A4 0.0431
576 Choline O-acetyltransferase CHAT 0.0431
769 High-affinity choline transporter 1 SLC5A7 0.0431
3922 Phospholipase D2 PLD2 0.0431
3924 Phospholipase D1 PLD1 0.0431
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0424
3669 Ribokinase rbsK 0.041
2892 Acetylglutamate kinase argB 0.0406
3550 Acetylglutamate kinase argB 0.0406
738 Monocarboxylate transporter 1 SLC16A1 0.0401
6395 Myosin-14 MYH14 0.04
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.04
404 DNA gyrase subunit A gyrA 0.0397
6224 DNA gyrase subunit A gyrA 0.0397
556 Alpha-1A adrenergic receptor ADRA1A 0.0393
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0386
3779 Alpha-2,3/8-sialyltransferase cst-II 0.0381
766 Beta-2 adrenergic receptor ADRB2 0.0376
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0369
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0356
6106 Cytochrome P450 2C18 CYP2C18 0.0348
136 Estrogen receptor ESR1 0.0348
378 Alpha-2C adrenergic receptor ADRA2C 0.0347
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0344
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0335
193 Beta-1 adrenergic receptor ADRB1 0.033
3692 Coenzyme A biosynthesis bifunctional protein coaBC coaBC 0.0329
477 DNA topoisomerase 4 subunit A parC 0.0326
886 DNA topoisomerase 4 subunit A parC 0.0326
6226 DNA topoisomerase 4 subunit A parC 0.0326
3188 IspD/ispF bifunctional enzyme [Includes: 2-C-methyl-D-erythritol 4- phosphate cytidylyltransferase ispDF 0.0319
474 Acetylcholinesterase ACHE 0.0318
2697 Uridine-cytidine kinase 2 UCK2 0.031
161 Tubulin beta chain TUBB 0.031
312 Tubulin beta chain TUB2 0.031
731 HIV-1 protease HIV-1 protease 0.031
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.03
492 Histamine H1 receptor HRH1 0.0292
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0291
2909 Cytidylate kinase cmk 0.0289
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0287
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0286
908 Glutathione S-transferase theta-1 GSTT1 0.0286
629 Alpha-2B adrenergic receptor ADRA2B 0.0281
3523 Spore coat polysaccharide biosynthesis protein spsA spsA 0.0281
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.028
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0279
831 D(2) dopamine receptor DRD2 0.0278
3957 Adenosine deaminase ADA 0.0276
4604 Liver carboxylesterase 1 CES1 0.0275
824 Sodium-dependent serotonin transporter SLC6A4 0.0273
318 Alpha-2A adrenergic receptor ADRA2A 0.0271
2765 3-deoxy-manno-octulosonate cytidylyltransferase kpsU 0.027
3120 3-deoxy-manno-octulosonate cytidylyltransferase kdsB 0.027
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0265
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0264
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0264
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0264
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0262
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0262
3917 Methylenetetrahydrofolate reductase MTHFR 0.026
504 Mast/stem cell growth factor receptor KIT 0.0259
124 Histamine H2 receptor HRH2 0.0259
2383 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0258
2937 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0258
4620 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0258
6594 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0258
6609 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0258
6646 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0258
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0255
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0253
632 Alpha-1B adrenergic receptor ADRA1B 0.0253
4482 UDP-galactose 4-epimerase galE 0.0253
1353 DNA topoisomerase 1 TOP1 0.0248
3552 DNA topoisomerase 1 topA 0.0248
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0248
1650 Heme carrier protein 1 SLC46A1 0.0244
3524 DNA beta-glucosyltransferase bgt 0.0243
3408 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 B3GAT3 0.0242
2608 UDP-N-acetylglucosamine 2-epimerase wecB 0.0242
617 Muscarinic acetylcholine receptor M2 CHRM2 0.024
1830 5'-nucleotidase NT5E 0.024
2291 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 B3GAT1 0.0237
904 Glutathione S-transferase P GSTP1 0.0236
3947 Xanthine dehydrogenase/oxidase XDH 0.0236
6167 Organic solute transporter subunit beta OSTB 0.0235
6166 Organic solute transporter subunit alpha OSTA 0.0235
789 Alpha-1D adrenergic receptor ADRA1D 0.0235
70 Type-1 angiotensin II receptor AGTR1 0.0229
6085 Fatty acid-binding protein, intestinal FABP2 0.0227
125 DNA polymerase beta POLB 0.0227
33 Cystine/glutamate transporter SLC7A11 0.0226
2590 Galactose-1-phosphate uridylyltransferase galT 0.0225
293 Gamma-glutamyl hydrolase GGH 0.0225
502 5-hydroxytryptamine 2A receptor HTR2A 0.0225
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0225
3270 Elongation factor G fusA 0.0218
844 Epidermal growth factor receptor EGFR 0.0216
6149 Solute carrier family 22 member 10 SLC22A10 0.0214
131 Synaptic vesicular amine transporter SLC18A2 0.0213
713 Sodium-dependent dopamine transporter SLC6A3 0.0213
6599 HTH-type transcriptional regulator ttgR ttgR 0.0213
6111 DNA polymerase epsilon subunit 4 POLE4 0.0211
3811 Cytochrome P450 19A1 CYP19A1 0.0211
6112 DNA polymerase epsilon subunit 3 POLE3 0.0211
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0211
6110 DNA polymerase epsilon subunit 2 POLE2 0.0211
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0211
29 Tubulin beta-1 chain TUBB1 0.0209
2439 Alpha,alpha-trehalose-phosphate synthase [UDP-forming] otsA 0.0209
6031 Cytochrome P450 3A43 CYP3A43 0.0207
1043 Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase GART 0.0205
23 D(1A) dopamine receptor DRD1 0.0205
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0204
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0203
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0202
3941 Amine oxidase [flavin-containing] A MAOA 0.0198
6165 Copper-transporting ATPase 1 ATP7A 0.0197
6163 Copper-transporting ATPase 2 ATP7B 0.0197
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0197
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0196
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0196
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0195
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0194
228 Beta platelet-derived growth factor receptor PDGFRB 0.0194
2539 Tubulin alpha-1 chain TUBA4A 0.0193
365 Dihydrofolate reductase DHFR 0.0192
2381 Dihydrofolate reductase DFR1 0.0192
2833 Dihydrofolate reductase Not Available 0.0192
2931 Dihydrofolate reductase folA 0.0192
3544 Dihydrofolate reductase folA 0.0192
3682 Dihydrofolate reductase folA 0.0192
6642 Dihydrofolate reductase folA 0.0192
6756 Dihydrofolate reductase dfrA 0.0192
2555 Pol polyprotein pol 0.0191
3242 Pol polyprotein gag-pol 0.0191
3471 Pol polyprotein gag-pro-pol 0.0191
5256 Pol polyprotein pol 0.0191
6469 Pol polyprotein gag-pol 0.0191
6565 Pol polyprotein Not Available 0.0191
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.019
2762 UDP-glucose 4-epimerase GALE 0.019
3461 UDP-glucose 4-epimerase galE 0.019
896 Glutathione S-transferase Mu 1 GSTM1 0.0189
338 DNA polymerase UL30 0.0189
379 DNA polymerase UL54 0.0189
697 DNA polymerase ORF28 0.0189
2482 DNA polymerase 43 0.0189
4104 DNA polymerase BALF5 0.0189
723 Cytosolic phospholipase A2 PLA2G4A 0.0189
6146 High affinity copper uptake protein 1 SLC31A1 0.0188
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0188
1882 Ras-related C3 botulinum toxin substrate 1 RAC1 0.0187
2170 Transforming protein RhoA RHOA 0.0187
3197 GDP-mannose mannosyl hydrolase nudD 0.0187
5628 Probable GTPase engC rsgA 0.0187
5630 ADP-ribosylation factor-like protein 5A ARL5A 0.0187
5618 ADP-ribosylation factor 4 ARF4 0.0187
5624 GTPase rab6 0.0187
5627 GDP-mannose 4,6-dehydratase gca 0.0187
3366 GTP-binding protein engA der 0.0187
614 Progesterone receptor PGR 0.0186
468 Cytochrome P450 4A11 CYP4A11 0.0183
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0182
4120 NADPH--cytochrome P450 reductase POR 0.0182
117 Sterol O-acyltransferase 1 SOAT1 0.018
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.018
3939 Amine oxidase [flavin-containing] B MAOB 0.0179
320 5-hydroxytryptamine 1A receptor HTR1A 0.0175
1757 Myeloperoxidase MPO 0.0173
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0173
6070 Nischarin NISCH 0.0172
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0171
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.017
3639 Thymidine phosphorylase deoA 0.0168
3936 Thymidine phosphorylase TYMP 0.0168
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0165
869 Estrogen receptor beta ESR2 0.0165
7 Nitric oxide synthase, inducible NOS2 0.0165
341 5-hydroxytryptamine 3 receptor HTR3A 0.0165
718 Folate receptor gamma FOLR3 0.0163
299 Folate receptor beta FOLR2 0.0163
804 Mitochondrial folate transporter/carrier SLC25A32 0.0163
26 Vascular endothelial growth factor receptor 3 FLT4 0.0163
237 Histo-blood group ABO system transferase ABO 0.0163
3335 Probable GTP-binding protein engB engB 0.0162
3354 Ras-related protein Rap-2a RAP2A 0.0162
3107 Putative GTP pyrophosphokinase relA 0.0162
5619 GDP-mannose 4,6 dehydratase GMDS 0.0161
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0161
380 Cytochrome P450 17A1 CYP17A1 0.0161
277 Purine nucleoside phosphorylase PNP 0.016
2870 Purine nucleoside phosphorylase punA 0.016
2945 Purine nucleoside phosphorylase punA 0.016
4659 Purine nucleoside phosphorylase TM_1596 0.016
4825 Purine nucleoside phosphorylase TTHA1435 0.016
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0159
3587 Gastrotropin FABP6 0.0159
6010 Thiamine transporter 1 SLC19A2 0.0159
465 Calmodulin CALM1 0.0159
3170 Elongation factor Tu-B tufB 0.0157
2472 Voltage-gated potassium channel kcsA 0.0157
6366 Voltage-gated potassium channel kcsA 0.0157
3396 Elongation factor Tu tufA 0.0156
5621 Elongation factor Tu tuf 0.0156
32 Vascular endothelial growth factor receptor 1 FLT1 0.0156
3115 Ras-related protein Rab-9 RAB9A 0.0156
3261 Signal recognition particle protein ffh 0.0155
13 Aminomethyltransferase, mitochondrial AMT 0.0154
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0154
633 Penicillin-binding proteins 1A/1B pbpA 0.0149
871 Glucocorticoid receptor NR3C1 0.0149
4192 DNA topoisomerase 2-beta TOP2B 0.0148
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0147
756 Sex hormone-binding globulin SHBG 0.0146
672 Prostaglandin F2-alpha receptor PTGFR 0.0146
273 Apoptosis regulator Bcl-2 BCL2 0.0145
6750 ADP-ribosylation factor 6 ARF6 0.0145
2521 Cell division protein ftsZ ftsZ 0.0145
3301 Cell division protein ftsZ ftsZ 0.0145
6012 Tryptophan 2,3-dioxygenase TDO2 0.0145
275 Arachidonate 5-lipoxygenase ALOX5 0.0142
175 Thiamin pyrophosphokinase 1 TPK1 0.0142
5849 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A 0.0142
6556 Elongation factor Tu GTP-binding domain-containing protein 1 EFTUD1 0.0141
592 Carbonic anhydrase 4 CA4 0.0141
1596 Protein-glutamine gamma-glutamyltransferase 2 TGM2 0.0141
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0141
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.014
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.014
407 Vascular endothelial growth factor receptor 2 KDR 0.0139
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0137
295 Carbonic anhydrase 1 CA1 0.0136
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0136
4203 Histamine N-methyltransferase HNMT 0.0136
6790 Elongation factor 2 EEF2 0.0136
373 Transthyretin TTR 0.0134
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0134
3810 Catechol O-methyltransferase COMT 0.0134
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0134
165 FL cytokine receptor FLT3 0.0134
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0131
357 Carbonic anhydrase 2 CA2 0.013
3307 Acriflavine resistance protein B acrB 0.013
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0129
1758 GTPase HRas HRAS 0.0129
645 Penicillin-binding protein 1A mrcA 0.0128
5805 Penicillin-binding protein 1A ponA 0.0128
6185 Penicillin-binding protein 1A mrcA 0.0128
6799 Penicillin-binding protein 1A pbpA 0.0128
2339 Protein-glutamine gamma-glutamyltransferase E TGM3 0.0127
6138 Multidrug resistance protein 3 ABCB4 0.0126
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0125
5126 Arginase rocF 0.0125
6316 ADP-ribosylation factor 1 ARF1 0.0124
461 Glycine receptor subunit alpha-3 GLRA3 0.0124
1852 Microtubule-associated protein 2 MAP2 0.0124
6218 Pannexin-1 PANX1 0.0124
308 30S ribosomal protein S12 rpsL 0.0122
6704 30S ribosomal protein S12 rpsL 0.0122
1636 Trace amine-associated receptor 1 TAAR1 0.0122
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0122
2320 Thymidine kinase, cytosolic TK1 0.0121
489 Monocarboxylate transporter 2 SLC16A7 0.0121
3978 Adenylosuccinate synthetase isozyme 1 ADSSL1 0.012
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0119
2331 HTH-type transcriptional regulator qacR qacR 0.0118
6461 HTH-type transcriptional regulator qacR qacR 0.0118
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0117
2727 S-adenosylmethionine synthetase metK 0.0117
5923 Microtubule-associated protein tau MAPT 0.0117
5924 Microtubule-associated protein 4 MAP4 0.0117
1341 Histamine H3 receptor HRH3 0.0117
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0117
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0116
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0116
1760 Aminopeptidase N ANPEP 0.0115
6843 Aminopeptidase N pepN 0.0115
164 Histamine H4 receptor HRH4 0.0115
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0114
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0114
2632 Adenylosuccinate synthetase purA 0.0113
3323 Adenylosuccinate synthetase purA 0.0113
3975 Adenylosuccinate synthetase ADSS 0.0113
4598 Adenylosuccinate synthetase Adss 0.0113
6817 Adenylosuccinate synthetase purA 0.0113
737 Mineralocorticoid receptor NR3C2 0.0113
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0112
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0112
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0112
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0112
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.011
4790 Glycosyltransferase GtfA gtfA 0.011
992 Protein tyrosine kinase 2 beta PTK2B 0.0109
2443 Azurin azu 0.0108
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0108
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0107
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0107
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0107
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0107
6014 Cytochrome P450 2A13 CYP2A13 0.0105
543 Penicillin-binding protein 1B mrcB 0.0105
6186 Penicillin-binding protein 1B ponB 0.0105
6822 Penicillin-binding protein 1b pbp1b 0.0105
6844 Penicillin-binding protein 1b pbp1b 0.0105
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0105
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0104
1629 Transcription factor AP-1 JUN 0.0104
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0104
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0104
952 Dipeptidyl peptidase 4 DPP4 0.0103
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0101
5682 Ribonuclease pancreatic RNASE1 0.0101
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0101
638 D(3) dopamine receptor DRD3 0.01
244 Angiotensin-converting enzyme ACE 0.0099
694 Matrix protein 2 M 0.0098
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0098
2449 Tubulin alpha-3 chain TUBA1A 0.0097
624 Guanidinoacetate N-methyltransferase GAMT 0.0097
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0097
6043 Putative G-protein coupled receptor 44 GPR44 0.0097
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0097
885 5-hydroxytryptamine 1B receptor HTR1B 0.0097
828 Phenylalanine-4-hydroxylase PAH 0.0097
3109 Phenylalanine-4-hydroxylase phhA 0.0097
1313 Lactoylglutathione lyase GLO1 0.0096
1517 Beta-3 adrenergic receptor ADRB3 0.0096
185 Vasopressin V1a receptor AVPR1A 0.0096
146 Androgen receptor AR 0.0096
2757 Inorganic pyrophosphatase ppa 0.0096
6238 Inorganic pyrophosphatase ppa 0.0096
6968 Inorganic pyrophosphatase PPA1 0.0096
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0095
5818 Folate receptor alpha FOLR1 0.0095
5787 Angiopoietin-1 receptor TEK 0.0095
6058 Geranylgeranyl pyrophosphate synthetase GGPS1 0.0095
6210 Tubulin delta chain TUBD1 0.0095
6212 Tubulin gamma-1 chain TUBG1 0.0095
6211 Tubulin epsilon chain TUBE1 0.0095
4217 Telomerase reverse transcriptase TERT 0.0094
6020 Aldehyde oxidase AOX1 0.0094
322 Vasopressin V2 receptor AVPR2 0.0093
887 DNA gyrase subunit B gyrB 0.0093
4150 DNA gyrase subunit B gyrB 0.0093
6225 DNA gyrase subunit B gyrB 0.0093
6432 Transporter snf 0.0092
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0092
853 Farnesyl pyrophosphate synthetase FDPS 0.0092
1405 Thiopurine S-methyltransferase TPMT 0.0092
4226 Uridine phosphorylase 2 UPP2 0.0092
2981 Phospholipase A2, membrane associated PLA2G2A 0.0091
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.0091
408 Riboflavin kinase RFK 0.0091
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.009
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0088
6220 Aryl hydrocarbon receptor AHR 0.0088
3685 Catabolite gene activator crp 0.0088
4655 Adenylate cyclase cyaC 0.0088
4759 Adenylate cyclase cyaB2 0.0088
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0087
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0087
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0086
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0086
1192 Sulfotransferase 1A1 SULT1A1 0.0086
4553 Bifunctional adenosylcobalamin biosynthesis protein cobU cobU 0.0084
2647 RNA-directed RNA polymerase P2 0.0084
4225 Uridine phosphorylase 1 UPP1 0.0084
2755 Hypoxanthine-guanine-xanthine phosphoribosyltransferase LACZ 0.0083
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0083
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0083
6042 Prostaglandin reductase 2 PTGR2 0.0083
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0083
432 D(4) dopamine receptor DRD4 0.0082
725 5-hydroxytryptamine 1D receptor HTR1D 0.0082
2016 Dipeptidase 1 DPEP1 0.0082
163 D(1B) dopamine receptor DRD5 0.0082
6126 Carbonic anhydrase 7 CA7 0.0082
850 Vasopressin V1b receptor AVPR1B 0.0081
2300 Lysozyme E 0.0081
3633 Lysozyme R 0.0081
5597 Lysozyme 17 0.0081
1141 Sialidase-1 NEU1 0.008
64 Neuraminidase NA 0.008
641 Neuraminidase NA 0.008
2676 Neuraminidase NA 0.008
3026 Neuraminidase NA 0.008
3519 Neuraminidase NA 0.008
6007 Neuraminidase NA 0.008
260 Cytochrome P450 51 ERG11 0.008
761 Cytochrome P450 51 ERG11 0.008
3163 Cytochrome P450 51 cyp51 0.008
183 Vascular endothelial growth factor A VEGFA 0.008
558 Solute carrier family 12 member 1 SLC12A1 0.0079
2808 Chloramphenicol acetyltransferase 3 cat3 0.0079
413 Amidophosphoribosyltransferase PPAT 0.0079
2515 Amidophosphoribosyltransferase purF 0.0079
3714 Amidophosphoribosyltransferase purF 0.0079
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0077
3010 Regulatory protein blaR1 blaR1 0.0077
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0077
2149 Angiogenin ANG 0.0077
207 Glutathione synthetase GSS 0.0075
5269 Glutathione synthetase gshB 0.0075
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0075
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0075
847 Mu-type opioid receptor OPRM1 0.0075
4760 Mll3241 protein mll3241 0.0075
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0074
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0074
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0074
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0074
6182 Cytochrome P450 2J2 CYP2J2 0.0074
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0074
3932 Glutathione S-transferase A2 GSTA2 0.0074
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0073
2885 Carboxyethyl-arginine beta-lactam-synthase bls 0.0073
22 30S ribosomal protein S4 rpsD 0.0072
6714 30S ribosomal protein S4 rpsD 0.0072
4600 Malonamidase E2 Not Available 0.0072
5304 UPF0166 protein TM_0021 TM_0021 0.0072
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0072
5287 Signaling protein Not Available 0.0072
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0072
3199 Phosphopantetheine adenylyltransferase coaD 0.0072
3543 Phosphopantetheine adenylyltransferase coaD 0.0072
3567 Phosphopantetheine adenylyltransferase coaD 0.0072
5289 Phosphopantetheine adenylyltransferase coaD 0.0072
5288 Shikimate kinase aroK 0.0072
5292 Putative partitioning protein TT_C1605 0.0072
5293 Shikimate kinase 2 aroL 0.0072
2874 Nitrogenase iron protein 1 nifH1 0.0072
5259 Transcriptional regulator ntrC1 0.0072
6699 Transcriptional regulator Cgl2612 0.0072
5281 Plasmid segregation protein parM parM 0.0072
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0072
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0072
5283 D-alanine--D-alanine ligase B ddlB 0.0072
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0072
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0072
4346 Polynucleotide kinase pseT 0.0072
5276 Chromosomal replication initiator protein dnaA dnaA 0.0072
5266 Activator of hgdC 0.0072
5291 Glycogen synthase 1 glgA1 0.0072
5284 Large T antigen Not Available 0.0072
5315 Chaperone protein htpG htpG 0.0072
5299 D-alanine--D-alanine ligase ddl 0.0072
6598 D-alanine--D-alanine ligase ddl 0.0072
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0072
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0072
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0072
5264 DNA replication protein REP 0.0072
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0072
5308 Preprotein translocase secA 1 subunit secA1 0.0072
5277 Preprotein translocase subunit secA secA 0.0072
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0072
5261 Phosphoribosylformylglycinamidine synthase purL 0.0072
5285 Kinesin heavy chain KIF5B 0.0072
467 Delta-type opioid receptor OPRD1 0.0072
1648 Elastin ELN 0.0072
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0072
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0072
115 Penicillin-binding protein 2 mrdA 0.0072
6069 Penicillin-binding protein 2 mrdA 0.0072
6118 Penicillin-binding protein 2 penA 0.0072
6187 Penicillin-binding protein 2 pbpA 0.0072
6686 Penicillin-binding protein 2 pbp2 0.0072
6939 Penicillin-binding protein 2 mrdA 0.0072
7163 Penicillin-binding protein 2 pbpA 0.0072
3809 Estrogen-related receptor gamma ESRRG 0.0071
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0071
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0071
340 Apoptotic protease-activating factor 1 APAF1 0.0071
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.007
6837 Serine/threonine-protein kinase 17B STK17B 0.007
6033 High affinity interleukin-8 receptor A CXCR1 0.007
2717 Folylpolyglutamate synthase fgs 0.007
2391 Ferrochelatase hemH 0.007
6502 Ferrochelatase DKFZp686P18130 0.007
1591 Ferrochelatase, mitochondrial FECH 0.007
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.007
1770 Phospholipase C PLCL1 0.007
2841 Phospholipase C plc 0.007
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0069
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0068
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0068
436 5-hydroxytryptamine 2B receptor HTR2B 0.0068
140 30S ribosomal protein S9 rpsI 0.0068
6719 30S ribosomal protein S9 rpsI 0.0068
6725 30S ribosomal protein S9 rpsI 0.0068
696 Kappa-type opioid receptor OPRK1 0.0068
5300 Antigen peptide transporter 1 TAP1 0.0068
1198 Serum paraoxonase/arylesterase 1 PON1 0.0068
6223 Penicillin-binding protein 1C pbpC 0.0068
2298 Cytochrome P450-cam camC 0.0068
3560 Gentamicin 3'-acetyltransferase aacC1 0.0067
4238 50S ribosomal protein L4 rplD 0.0067
5578 50S ribosomal protein L4 rplD 0.0067
6173 50S ribosomal protein L4 rplD 0.0067
6219 50S ribosomal protein L4 rplD 0.0067
1 Peptidoglycan synthetase ftsI ftsI 0.0066
4155 Peptidoglycan synthetase ftsI ftsI 0.0066
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0066
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0066
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0066
2428 Thiamine-phosphate pyrophosphorylase thiE 0.0065
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0065
2599 Tyrosine-protein kinase HCK HCK 0.0064
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0063
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0063
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0063
2021 Thrombomodulin THBD 0.0063
6168 Solute carrier family 22 member 16 SLC22A16 0.0063
5482 Sialidase-2 NEU2 0.0062
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0062
4237 50S ribosomal protein L22 rplV 0.0062
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0061
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0061
153 Dopamine beta-hydroxylase DBH 0.0061
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0061
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0061
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0061
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0061
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0061
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0061
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.006
6493 Cytochrome c oxidase subunit 6C COX6C 0.006
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.006
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.006
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.006
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.006
6559 Cytochrome c oxidase subunit 2 ctaC 0.006
6669 Cytochrome c oxidase subunit 2 ctaC 0.006
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.006
371 Cytochrome c oxidase subunit 1 MT-CO1 0.006
6558 Cytochrome c oxidase subunit 1 ctaD 0.006
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.006
4106 Guanylate kinase GUK1 0.006
4516 Guanylate kinase gmk 0.006
6277 Heat shock cognate 71 kDa protein HSPA8 0.0059
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0059
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0059
1360 Sphingomyelin phosphodiesterase SMPD1 0.0059
4837 Cag-alfa cag-alfa 0.0059
5646 Galactokinase GALK1 0.0059
4774 NTPase P4 Not Available 0.0059
5302 TrwB trwB 0.0059
5265 FtsH ftsH 0.0059
4838 PMS1 protein homolog 2 PMS2 0.0059
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0059
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0059
4839 DNA polymerase III subunit tau dnaX 0.0059
1618 High affinity nerve growth factor receptor NTRK1 0.0059
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0059
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0059
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0059
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0059
2270 Dephospho-CoA kinase coaE 0.0059
2284 Adenylate kinase adk 0.0058
2296 Adenylate kinase adk 0.0058
2311 Adenylate kinase adk 0.0058
2312 Adenylate kinase Not Available 0.0058
5189 Trimethylamine dehydrogenase tmd 0.0058
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0058
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0058
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0058
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0058
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0058
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0058
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0058
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0058
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0058
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0058
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0058
3470 Hypothetical protein MG245 homolog MPN_348 0.0058
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0058
3175 Glutamate--cysteine ligase gshA 0.0057
3426 Glutamine synthetase glnA 0.0057
3987 Glutamine synthetase GLUL 0.0057
527 Prostacyclin receptor PTGIR 0.0057
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0057
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0056
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0056
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0056
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0056
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0056
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0056
777 Tumor necrosis factor TNF 0.0056
1050 Bile salt sulfotransferase SULT2A1 0.0055
2540 Choloylglycine hydrolase cbh 0.0055
590 5-hydroxytryptamine 2C receptor HTR2C 0.0055
466 Solute carrier family 12 member 3 SLC12A3 0.0055
2683 Mono-ADP-ribosyltransferase C3 C3 0.0055
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0054
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0054
2390 Nonsecretory ribonuclease RNASE2 0.0054
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0054
5312 Kinesin-like protein KIF1A KIF1A 0.0053
2922 Glycerol kinase glpK 0.0053
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0052
976 Platelet glycoprotein IX GP9 0.0052
6501 Fatty acid-binding protein, liver FABP1 0.0052
5271 Focal adhesion kinase 1 PTK2 0.0052
2282 Protein recA recA 0.0051
2315 Protein recA recA 0.0051
2332 Protein recA recA 0.0051
5263 Protein recA recA 0.0051
438 Taste receptor type 1 member 2 TAS1R2 0.0051
1864 RET proto-oncogene RET 0.0051
469 Annexin A1 ANXA1 0.0051
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0051
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0051
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0051
253 Sodium/potassium-transporting ATPase gamma chain FXYD2 0.0051
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.005
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.005
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.005
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.005
2615 Chemotaxis protein cheA cheA 0.005
1881 Hexokinase-1 HK1 0.0049
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0049
2371 Pantothenate kinase coaA 0.0049
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0049
1714 Mitogen-activated protein kinase 3 MAPK3 0.0049
284 DNA-directed RNA polymerase beta chain rpoB 0.0049
5773 DNA-directed RNA polymerase beta chain rpoB 0.0049
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0048
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0048
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0048
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0048
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0048
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0048
6228 Nuclear receptor coactivator 1 NCOA1 0.0047
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0047
6241 Nuclear receptor coactivator 2 NCOA2 0.0047
2616 Ganglioside GM2 activator GM2A 0.0047
4034 Glutaredoxin-1 GLRX 0.0046
1928 Leukotriene C4 synthase LTC4S 0.0046
4043 Glutaredoxin-2, mitochondrial GLRX2 0.0046
4037 Hypothetical protein GPX1 0.0046
4297 Hypothetical protein SP_1951 0.0046
4521 Hypothetical protein BC_2969 0.0046
4540 Hypothetical protein TM_1070 0.0046
4555 Hypothetical protein MT1739 0.0046
4569 Hypothetical protein mshD 0.0046
4578 Hypothetical protein PA3270 0.0046
4747 Hypothetical protein PA3967 0.0046
5177 Hypothetical protein TM_0096 0.0046
5194 Hypothetical protein PA1204 0.0046
5240 Hypothetical protein Rv2991 0.0046
5370 Hypothetical protein TM_1158 0.0046
5710 Hypothetical protein Tb927.5.1360 0.0046
4029 Microsomal glutathione S-transferase 3 MGST3 0.0046
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.0046
907 Glutathione peroxidase 2 GPX2 0.0046
4032 Microsomal glutathione S-transferase 1 MGST1 0.0046
910 Epididymal secretory glutathione peroxidase GPX5 0.0046
4036 Glutathione peroxidase 6 GPX6 0.0046
903 Glutathione S-transferase A5 GSTA5 0.0046
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.0046
4040 Glutathione peroxidase 7 GPX7 0.0046
911 Glutathione peroxidase 3 GPX3 0.0046
906 Glutathione peroxidase 1 GPX1 0.0046
900 Glutathione S-transferase A4 GSTA4 0.0046
4035 Glutathione S-transferase Mu 5 GSTM5 0.0046
4033 S-formylglutathione hydrolase ESD 0.0046
4042 Glutathione transferase omega-2 GSTO2 0.0046
4038 Glutathione peroxidase 4 GPX4 0.0046
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.0046
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.0046
751 Potassium channel subfamily K member 6 KCNK6 0.0046
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0046
3856 Fibroblast growth factor receptor 3 FGFR3 0.0046
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0046
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0046
3686 Acyl-CoA thioesterase I precursor tesA 0.0045
303 Diamine acetyltransferase 2 SAT2 0.0045
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0045
788 Creatine kinase M-type CKM 0.0045
623 Spermine oxidase SMOX 0.0045
1317 Spermine synthase SMS 0.0045
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0044
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0044
6500 Phospholipase A2 PLA2G1B 0.0044
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0044
2334 Dethiobiotin synthetase bioD 0.0043
6555 Dethiobiotin synthetase bioD 0.0043
1792 Tissue-type plasminogen activator PLAT 0.0043
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0043
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0043
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0043
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0043
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.0043
65 Matrix metalloproteinase-9 Not Available 0.0043
5698 Riboflavin synthase alpha chain ribE 0.0043
172 Potassium channel subfamily K member 1 KCNK1 0.0042
3319 Hydroxyacylglutathione hydrolase HAGH 0.0042
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0042
898 Glutathione S-transferase A3 GSTA3 0.0042
76 Nitric-oxide synthase, brain NOS1 0.0042
897 Glutathione S-transferase kappa 1 GSTK1 0.0042
48 Pyridoxal kinase PDXK 0.0042
909 Maleylacetoacetate isomerase GSTZ1 0.0041
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0041
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0041
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0041
905 Glutathione transferase omega-1 GSTO1 0.004
899 Glutathione S-transferase Mu 3 GSTM3 0.004
511 5-hydroxytryptamine 1F receptor HTR1F 0.004
123 Diamine acetyltransferase 1 SAT1 0.004
2091 Endoplasmin HSP90B1 0.004
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.004
4041 Microsomal glutathione S-transferase 2 MGST2 0.004
1558 Transient receptor potential cation channel subfamily V member 1 TRPV1 0.004
291 Nitric-oxide synthase, endothelial NOS3 0.0039
1721 Glycogen synthase kinase-3 beta GSK3B 0.0039
517 Alcohol dehydrogenase 1C ADH1C 0.0039
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0039
1422 Serine/threonine-protein kinase 6 AURKA 0.0038
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0038
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0038
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0038
2232 Interleukin-5 IL5 0.0037
1593 Mucin-2 MUC2 0.0037
5353 Glutamate decarboxylase alpha gadA 0.0037
106 Cannabinoid receptor 2 CNR2 0.0037
2165 Glutathione S-transferase Mu 2 GSTM2 0.0037
3379 Kinesin-like protein KIF11 KIF11 0.0037
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0037
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0037
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0037
3822 Actin, alpha skeletal muscle ACTA1 0.0036
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0036
122 P2Y purinoceptor 12 P2RY12 0.0036
707 72 kDa type IV collagenase MMP2 0.0036
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0036
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0036
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0036
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0036
68 Cannabinoid receptor 1 CNR1 0.0036
1569 G1/S-specific cyclin-D1 CCND1 0.0036
1074 Urokinase-type plasminogen activator PLAU 0.0036
239 Coagulation factor X F10 0.0035
6131 Carbonic anhydrase 14 CA14 0.0035
936 Ephrin type-A receptor 2 EPHA2 0.0035
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0035
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0035
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0035
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0035
901 Glutathione S-transferase Mu 4 GSTM4 0.0035
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0034
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0034
6122 Carbonic anhydrase 3 CA3 0.0033
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0033
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0033
332 Beta-lactamase blaZ 0.0033
2478 Beta-lactamase ampC 0.0033
2613 Beta-lactamase ampC 0.0033
2635 Beta-lactamase ampC 0.0033
2700 Beta-lactamase penP 0.0033
5445 Beta-lactamase blaB 0.0033
6019 Beta-lactamase SHV-7 0.0033
6701 Beta-lactamase cphA 0.0033
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0033
3007 Carbonic anhydrase 12 CA12 0.0033
2251 Thymidylate kinase tmk 0.0033
2254 Thymidylate kinase DTYMK 0.0033
3522 Thymidylate kinase tmk 0.0033
4205 Carbonic anhydrase 9 CA9 0.0033
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0032
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0032
2257 Uridine phosphorylase udp 0.0031
5132 Uridine phosphorylase udp 0.0031
449 Ornithine decarboxylase ODC1 0.0031
2499 Tubulin beta-2C chain TUBB2C 0.0031
4031 Glutathione S-transferase A1 GSTA1 0.0031
1123 Eosinophil cationic protein RNASE3 0.0031
823 Fibroblast growth factor receptor 2 FGFR2 0.003
484 Tyrosine-protein kinase ABL2 ABL2 0.003
714 Glutathione reductase, mitochondrial GSR 0.003
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.003
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.003
6824 Tyrosine-protein kinase Lyn LYN 0.003
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0029
654 Flavin reductase BLVRB 0.0029
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0029
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0029
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0029
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0029
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0029
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0029
683 Potassium transporter GK0582 0.0029
3688 Branched-chain-amino-acid aminotransferase ilvE 0.0028
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0028
4252 Penicillin-binding protein 5 dacA 0.0028
159 Penicillin-binding protein 2B penA 0.0028
6121 Penicillin-binding protein 2B penA 0.0028
1867 Major prion protein PRNP 0.0028
921 Glutamate receptor 2 GRIA2 0.0027
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0027
1025 Aquaporin-1 AQP1 0.0027
818 50S ribosomal protein L10 rplJ 0.0026
1630 Integrin beta-2 ITGB2 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0026
130 Prostacyclin synthase PTGIS 0.0025
3959 Cell division protein kinase 4 CDK4 0.0025
509 Thymidine kinase TK 0.0025
570 Thymidine kinase TK 0.0025
2559 Thymidine kinase TK 0.0025
3430 Thymidine kinase tdk 0.0025
3518 Thymidine kinase TK 0.0025
5301 Thymidine kinase tdk 0.0025
5771 Thymidine kinase ORF36 0.0025
7009 Thymidine kinase ORF36 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
84 Nuclear receptor 0B1 NR0B1 0.0025
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0024
6207 30S ribosomal protein S14 rpsN 0.0024
6209 30S ribosomal protein S19 rpsS 0.0024
6712 30S ribosomal protein S19 rpsS 0.0024
6726 30S ribosomal protein S19 rpsS 0.0024
319 Opioid receptor, sigma 1 OPRS1 0.0024
4148 Serine/threonine-protein kinase mTOR MTOR 0.0024
471 Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+) SLC6A14 0.0024
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0024
1176 Mitogen-activated protein kinase 1 MAPK1 0.0024
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0024
2216 Fibroblast growth factor receptor 4 FGFR4 0.0024
4103 Proteasome subunit beta type 2 PSMB2 0.0023
4102 Proteasome subunit beta type 5 PSMB5 0.0023
4101 Proteasome subunit beta type 1 PSMB1 0.0023
3955 Cell division protein kinase 6 CDK6 0.0023
1063 Signal transducer and activator of transcription 5B STAT5B 0.0023
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
459 Retinoic acid receptor RXR-alpha RXRA 0.0023
2249 Aspartate aminotransferase aspC 0.0023
2671 Aspartate aminotransferase aspC 0.0023
5490 Aspartate aminotransferase Not Available 0.0023
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0023
716 5-hydroxytryptamine 7 receptor HTR7 0.0021
6044 Serum paraoxonase/lactonase 3 PON3 0.0021
1196 Complement decay-accelerating factor CD55 0.0021
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0021
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.002
1656 CYP2B protein CYP2B 0.002
2240 Cell division protein kinase 2 CDK2 0.002
572 Integrin alpha-L ITGAL 0.002
1058 Cell division protein kinase 5 CDK5 0.002
2107 Microtubule-associated protein 1A MAP1A 0.002
867 Penicillin-binding protein 3 pbpC 0.0019
6119 Penicillin-binding protein 3 pbp3 0.0019
7154 Penicillin-binding protein 3 pbp3 0.0019
7157 Penicillin-binding protein 3 LMHCC_2184 0.0019
7162 Penicillin-binding protein 3 pbpB 0.0019
7172 Penicillin-binding protein 3 pbp3 0.0019
5798 Mitogen-activated protein kinase 11 MAPK11 0.0019
1654 Interleukin-1 beta IL1B 0.0019
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0019
4122 Histone deacetylase 2 HDAC2 0.0018
3920 Methylenetetrahydrofolate reductase intermediate form MTHFR 0.0018
3763 5,10-methylenetetrahydrofolate reductase metF 0.0018
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0018
5094 5,10-methylenetetrahydrofolate reductase metF 0.0018
59 AMT protein AMT 0.0018
3919 Methionyl-tRNA formyltransferase, mitochondrial MTFMT 0.0018
1202 10-formyltetrahydrofolate dehydrogenase ALDH1L1 0.0018
53 Solute carrier family 12 member 5 SLC12A5 0.0018
663 Solute carrier family 12 member 4 SLC12A4 0.0018
760 Fibroblast growth factor 1 FGF1 0.0017
2417 Chloramphenicol acetyltransferase cat 0.0017
3278 Chloramphenicol acetyltransferase cat 0.0017
594 Thyroxine-binding globulin SERPINA7 0.0017
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0017
2810 Dr hemagglutinin structural subunit draA 0.0017
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0017
768 FK506-binding protein 1A FKBP1A 0.0017
310 Solute carrier family 12 member 2 SLC12A2 0.0017
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0016
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0016
6766 O-GlcNAcase BT_4395 BT_4395 0.0016
2408 Tyrosine-protein kinase SYK SYK 0.0016
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0016
758 Thyroid hormone receptor alpha THRA 0.0016
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0015
494 Caspase-1 CASP1 0.0015
6755 Poliovirus receptor PVR 0.0015
605 Fumarate reductase flavoprotein subunit frdA 0.0015
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0015
3673 Fumarate reductase flavoprotein subunit fccA 0.0015
4912 Fumarate reductase flavoprotein subunit ifcA 0.0015
6549 Fumarate reductase flavoprotein subunit frdA 0.0015
1275 Estrogen sulfotransferase SULT1E1 0.0015
1507 Cytochrome c CYCS 0.0015
1178 Adenosine A2a receptor ADORA2A 0.0014
3884 SHMT2 protein SHMT2 0.0014
3901 SHMT2 protein SHMT2 0.0014
3885 Hypothetical protein DKFZp686P09201 DKFZp686P09201 0.0014
3879 Serine hydroxymethyltransferase 2 Not Available 0.0014
321 Serine hydroxymethyltransferase, mitochondrial SHMT2 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
346 Thyroid hormone receptor beta-1 THRB 0.0014
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0014
3760 Penicillin-binding protein 5 precursor dacA 0.0014
6102 Arylamine N-acetyltransferase 2 NAT2 0.0014
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0014
822 Aldose reductase AKR1B1 0.0014
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0013
809 Methionine synthase MTR 0.0013
2935 Methionine synthase metH 0.0013
825 Arsenical pump-driving ATPase ASNA1 0.0013
3435 Arsenical pump-driving ATPase arsA 0.0013
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0013
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0013
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0013
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0013
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0013
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0013
733 Activin receptor type 1B ACVR1B 0.0013
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0013
154 AFG3-like protein 2 AFG3L2 0.0013
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0013
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0013
395 ALK tyrosine kinase receptor Not Available 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
2077 Caspase-3 CASP3 0.0013
1010 Cytochrome P450 51A1 CYP51A1 0.0013
528 5-hydroxytryptamine 1E receptor HTR1E 0.0013
819 Penicillin-binding protein 4 dacB 0.0012
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0012
367 Serine hydroxymethyltransferase, cytosolic SHMT1 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
2297 Genome polyprotein Not Available 0.0012
2322 Genome polyprotein Not Available 0.0012
2694 Genome polyprotein Not Available 0.0012
2719 Genome polyprotein Not Available 0.0012
2860 Genome polyprotein Not Available 0.0012
2928 Genome polyprotein Not Available 0.0012
3160 Genome polyprotein Not Available 0.0012
3260 Genome polyprotein Not Available 0.0012
4783 Genome polyprotein Not Available 0.0012
5726 Genome polyprotein Not Available 0.0012
5779 Genome polyprotein Not Available 0.0012
5867 Genome polyprotein Not Available 0.0012
6253 Genome polyprotein Not Available 0.0012
6301 Genome polyprotein Not Available 0.0012
6380 Genome polyprotein Not Available 0.0012
6381 Genome polyprotein Not Available 0.0012
6437 Genome polyprotein Not Available 0.0012
6520 Genome polyprotein Not Available 0.0012
6521 Genome polyprotein Not Available 0.0012
6652 Genome polyprotein Not Available 0.0012
6734 Genome polyprotein Not Available 0.0012
6735 Genome polyprotein Not Available 0.0012
6736 Genome polyprotein Not Available 0.0012
6737 Genome polyprotein Not Available 0.0012
6738 Genome polyprotein Not Available 0.0012
6739 Genome polyprotein Not Available 0.0012
6744 Genome polyprotein Not Available 0.0012
6748 Genome polyprotein Not Available 0.0012
6894 Genome polyprotein Not Available 0.0012
6898 Genome polyprotein Not Available 0.0012
292 Activin receptor type-1 ACVR1 0.0012
849 Activated CDC42 kinase 1 TNK2 0.0012
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
6859 Protein S100-A4 S100A4 0.0012
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0011
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0011
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0011
297 Adenylate cyclase type 1 ADCY1 0.0011
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0011
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0011
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.0011
5756 D-alanyl-D-alanine carboxypeptidase dac 0.0011
2112 Toll-like receptor 9 TLR9 0.0011
6459 Glycodelin PAEP 0.0011
232 Corticosteroid-binding globulin SERPINA6 0.0011
427 Substance-P receptor TACR1 0.0011
144 Hemoglobin subunit alpha HBA1 0.001
997 Protein kinase C beta type PRKCB 0.001
6174 50S ribosomal protein L32 rpmF 0.001
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.001
811 Translocator protein TSPO 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
740 Argininosuccinate synthase ASS1 0.001
865 Argininosuccinate synthase ASS1 0.001
2680 Argininosuccinate synthase argG 0.001
3194 Argininosuccinate synthase argG 0.001
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.001
199 Monocarboxylate transporter 8 SLC16A2 0.001
634 Squalene monooxygenase SQLE 0.001
7196 Squalene monooxygenase ERG1 0.001
1970 Protein kinase C alpha type PRKCA 0.001
661 ADP/ATP translocase 1 SLC25A4 0.0009
1039 Histone deacetylase 9 HDAC9 0.0009
6021 Adenosine kinase ADK 0.0009
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0009
1291 cAMP response element-binding protein CREB1 0.0009
1525 Heparin-binding growth factor 2 FGF2 0.0009
4210 Toll-like receptor 4 TLR4 0.0009
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0009
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0009
54 Prothrombin F2 0.0009
1262 Corticotropin-lipotropin POMC 0.0009
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0008
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
229 Retinoic acid receptor beta RARB 0.0008
780 Retinoic acid receptor RXR-gamma RXRG 0.0008
730 Retinoic acid receptor alpha RARA 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
88 Retinoic acid receptor RXR-beta RXRB 0.0007
162 Retinoic acid receptor gamma-1 RARG 0.0007
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0007
2236 Casein kinase II subunit alpha CSNK2A1 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
6151 Monocarboxylate transporter 10 SLC16A10 0.0007
1256 5-hydroxytryptamine 6 receptor HTR6 0.0007
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
1374 Natriuretic peptides B NPPB 0.0006
1827 Gap junction alpha-1 protein GJA1 0.0006
1908 Vascular cell adhesion protein 1 VCAM1 0.0006
814 Ryanodine receptor 1 RYR1 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0006
6677 Myelin P2 protein PMP2 0.0006
174 Sigma 1-type opioid receptor SIGMAR1 0.0006
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0006
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0005
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0005
2207 Rhodopsin RHO 0.0005
2183 Fatty acid-binding protein, adipocyte FABP4 0.0005
16 Adenosine A1 receptor ADORA1 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
3221 Cytochrome c4 cc4 0.0005
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0004
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0004
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0004
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0004
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0004
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0004
5934 Cytochrome P450 26A1 CYP26A1 0.0004
4311 tRNA TRDMT1 0.0004
4325 tRNA trmD 0.0004
4328 tRNA trmD 0.0004
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0004
2802 Endoglucanase G celCCG 0.0004
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0004
444 Alcohol dehydrogenase 1B ADH1B 0.0003
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