DT-Web

DB02345 - Selenocysteine


Identification
Name Selenocysteine
Accession Number DB02345 (EXPT01033)
Type small molecule
Description A naturally occurring amino acid in both eukaryotic and prokaryotic organisms. It is found in tRNAs and in the catalytic site of some enzymes. The genes for glutathione peroxidase and formate dehydrogenase contain the TGA codon, which codes for this amino acid. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 168.05
Groups experimental
Monoisotopic Weight 168.964200301
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Cathelicidin antimicrobial peptide
Name Cathelicidin antimicrobial peptide
Gene Name CAMP
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
Nucleoside diphosphate kinase A
Name Nucleoside diphosphate kinase A
Gene Name NME1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.4599
Formate dehydrogenase H
Name Formate dehydrogenase H
Gene Name fdhF
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.911
Cysteine desulfurase
Name Cysteine desulfurase
Gene Name sufS
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.4456

Predictions


Id Partner name Gene Name Score
868 Cystathionine gamma-lyase CTH 0.1821
2633 Anaerobic ribonucleoside-triphosphate reductase NRDD 0.0662
3204 Thiosulfate sulfurtransferase glpE glpE 0.0625
3527 Thiosulfate sulfurtransferase rhdA 0.0625
4806 Thiosulfate sulfurtransferase TTHA1028 0.0625
6965 Thiosulfate sulfurtransferase TST 0.0625
4801 Diphtheria toxin repressor dtxR 0.0625
4803 3-mercaptopyruvate sulfurtransferase sseA 0.0624
4802 L-cysteine/cystine lyase C-DES c-des 0.0544
3274 Hydroxylamine reductase hcp 0.0544
4804 Hydroxylamine reductase hcp 0.0544
4134 Mercaptopyruvate sulfurtransferase MST 0.0543
5626 Nucleoside diphosphate kinase B NME2 0.0434
2164 Multidrug resistance-associated protein 4 ABCC4 0.0189
342 P protein [Includes: DNA-directed DNA polymerase P 0.0162
612 P protein [Includes: DNA-directed DNA polymerase P 0.0162
1729 Solute carrier family 22 member 6 SLC22A6 0.0154
6142 Solute carrier family 22 member 8 SLC22A8 0.0136
6147 Solute carrier family 22 member 3 SLC22A3 0.0118
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.01
2757 Inorganic pyrophosphatase ppa 0.0096
6238 Inorganic pyrophosphatase ppa 0.0096
6968 Inorganic pyrophosphatase PPA1 0.0096
2383 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0096
2937 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0096
4620 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0096
6594 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0096
6609 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0096
6646 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0096
6148 Multidrug resistance-associated protein 7 ABCC10 0.0091
6136 Multidrug resistance-associated protein 5 ABCC5 0.0091
4553 Bifunctional adenosylcobalamin biosynthesis protein cobU cobU 0.0084
2647 RNA-directed RNA polymerase P2 0.0084
2755 Hypoxanthine-guanine-xanthine phosphoribosyltransferase LACZ 0.0083
2727 S-adenosylmethionine synthetase metK 0.0083
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0083
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0083
702 UMP-CMP kinase CMPK1 0.008
3010 Regulatory protein blaR1 blaR1 0.0077
2149 Angiogenin ANG 0.0077
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0074
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0074
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0074
2885 Carboxyethyl-arginine beta-lactam-synthase bls 0.0073
6395 Myosin-14 MYH14 0.0073
4600 Malonamidase E2 Not Available 0.0072
2717 Folylpolyglutamate synthase fgs 0.007
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0068
2428 Thiamine-phosphate pyrophosphorylase thiE 0.0065
4773 Deoxycytidine kinase DCK 0.0062
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0055
1882 Ras-related C3 botulinum toxin substrate 1 RAC1 0.0053
3197 GDP-mannose mannosyl hydrolase nudD 0.0053
5628 Probable GTPase engC rsgA 0.0053
5630 ADP-ribosylation factor-like protein 5A ARL5A 0.0053
5618 ADP-ribosylation factor 4 ARF4 0.0053
2170 Transforming protein RhoA RHOA 0.0053
5624 GTPase rab6 0.0053
3366 GTP-binding protein engA der 0.0053
5627 GDP-mannose 4,6-dehydratase gca 0.0053
4200 Cytochrome P450 1A2 CYP1A2 0.0052
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0047
3335 Probable GTP-binding protein engB engB 0.0046
3354 Ras-related protein Rap-2a RAP2A 0.0046
3107 Putative GTP pyrophosphokinase relA 0.0046
5619 GDP-mannose 4,6 dehydratase GMDS 0.0046
3396 Elongation factor Tu tufA 0.0046
5621 Elongation factor Tu tuf 0.0046
3170 Elongation factor Tu-B tufB 0.0046
3115 Ras-related protein Rab-9 RAB9A 0.0046
3270 Elongation factor G fusA 0.0046
3261 Signal recognition particle protein ffh 0.0046
6750 ADP-ribosylation factor 6 ARF6 0.0042
2521 Cell division protein ftsZ ftsZ 0.0042
3301 Cell division protein ftsZ ftsZ 0.0042
6447 Guanine nucleotide-binding protein G(t) subunit alpha-1 GNAT1 0.0042
6556 Elongation factor Tu GTP-binding domain-containing protein 1 EFTUD1 0.0042
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.004
6790 Elongation factor 2 EEF2 0.004
1596 Protein-glutamine gamma-glutamyltransferase 2 TGM2 0.0039
1758 GTPase HRas HRAS 0.0038
862 Multidrug resistance-associated protein 1 ABCC1 0.0036
2339 Protein-glutamine gamma-glutamyltransferase E TGM3 0.0036
6316 ADP-ribosylation factor 1 ARF1 0.0036
6144 Solute carrier family 22 member 2 SLC22A2 0.0034
3978 Adenylosuccinate synthetase isozyme 1 ADSSL1 0.0034
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0034
6145 Solute carrier family 22 member 1 SLC22A1 0.0034
2632 Adenylosuccinate synthetase purA 0.0033
3323 Adenylosuccinate synthetase purA 0.0033
3975 Adenylosuccinate synthetase ADSS 0.0033
4598 Adenylosuccinate synthetase Adss 0.0033
6817 Adenylosuccinate synthetase purA 0.0033
1588 Multidrug resistance protein 1 ABCB1 0.0026
5304 UPF0166 protein TM_0021 TM_0021 0.0018
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0018
3199 Phosphopantetheine adenylyltransferase coaD 0.0018
3543 Phosphopantetheine adenylyltransferase coaD 0.0018
3567 Phosphopantetheine adenylyltransferase coaD 0.0018
5289 Phosphopantetheine adenylyltransferase coaD 0.0018
5288 Shikimate kinase aroK 0.0018
5287 Signaling protein Not Available 0.0018
5259 Transcriptional regulator ntrC1 0.0018
6699 Transcriptional regulator Cgl2612 0.0018
5293 Shikimate kinase 2 aroL 0.0018
5292 Putative partitioning protein TT_C1605 0.0017
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0017
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0017
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0017
5266 Activator of hgdC 0.0017
5291 Glycogen synthase 1 glgA1 0.0017
2874 Nitrogenase iron protein 1 nifH1 0.0017
4346 Polynucleotide kinase pseT 0.0017
5264 DNA replication protein REP 0.0017
5283 D-alanine--D-alanine ligase B ddlB 0.0017
5281 Plasmid segregation protein parM parM 0.0017
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0017
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0017
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0017
5299 D-alanine--D-alanine ligase ddl 0.0017
6598 D-alanine--D-alanine ligase ddl 0.0017
5284 Large T antigen Not Available 0.0017
5276 Chromosomal replication initiator protein dnaA dnaA 0.0017
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0017
5277 Preprotein translocase subunit secA secA 0.0017
5308 Preprotein translocase secA 1 subunit secA1 0.0017
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0017
5285 Kinesin heavy chain KIF5B 0.0017
5315 Chaperone protein htpG htpG 0.0017
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0017
5261 Phosphoribosylformylglycinamidine synthase purL 0.0017
4106 Guanylate kinase GUK1 0.0015
4516 Guanylate kinase gmk 0.0015
413 Amidophosphoribosyltransferase PPAT 0.0015
2515 Amidophosphoribosyltransferase purF 0.0015
3714 Amidophosphoribosyltransferase purF 0.0015
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0015
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0015
4774 NTPase P4 Not Available 0.0015
5646 Galactokinase GALK1 0.0015
6277 Heat shock cognate 71 kDa protein HSPA8 0.0015
4837 Cag-alfa cag-alfa 0.0015
5265 FtsH ftsH 0.0015
4838 PMS1 protein homolog 2 PMS2 0.0015
5302 TrwB trwB 0.0015
4839 DNA polymerase III subunit tau dnaX 0.0015
2270 Dephospho-CoA kinase coaE 0.0015
5189 Trimethylamine dehydrogenase tmd 0.0015
2284 Adenylate kinase adk 0.0015
2296 Adenylate kinase adk 0.0015
2311 Adenylate kinase adk 0.0015
2312 Adenylate kinase Not Available 0.0015
3470 Hypothetical protein MG245 homolog MPN_348 0.0015
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0015
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0015
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0015
3426 Glutamine synthetase glnA 0.0015
3987 Glutamine synthetase GLUL 0.0015
3175 Glutamate--cysteine ligase gshA 0.0015
340 Apoptotic protease-activating factor 1 APAF1 0.0014
2683 Mono-ADP-ribosyltransferase C3 C3 0.0014
2390 Nonsecretory ribonuclease RNASE2 0.0014
5312 Kinesin-like protein KIF1A KIF1A 0.0014
2922 Glycerol kinase glpK 0.0013
5271 Focal adhesion kinase 1 PTK2 0.0013
2282 Protein recA recA 0.0013
2315 Protein recA recA 0.0013
2332 Protein recA recA 0.0013
5263 Protein recA recA 0.0013
2615 Chemotaxis protein cheA cheA 0.0013
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0013
2371 Pantothenate kinase coaA 0.0013
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0013
1881 Hexokinase-1 HK1 0.0013
3669 Ribokinase rbsK 0.0013
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0013
2892 Acetylglutamate kinase argB 0.0013
3550 Acetylglutamate kinase argB 0.0013
825 Arsenical pump-driving ATPase ASNA1 0.0013
3435 Arsenical pump-driving ATPase arsA 0.0013
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0013
5300 Antigen peptide transporter 1 TAP1 0.0012
408 Riboflavin kinase RFK 0.0012
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0012
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0012
2697 Uridine-cytidine kinase 2 UCK2 0.0012
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0012
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0012
788 Creatine kinase M-type CKM 0.0012
2334 Dethiobiotin synthetase bioD 0.0011
6555 Dethiobiotin synthetase bioD 0.0011
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0011
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0011
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0011
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0011
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0011
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0011
2251 Thymidylate kinase tmk 0.001
2254 Thymidylate kinase DTYMK 0.001
3522 Thymidylate kinase tmk 0.001
48 Pyridoxal kinase PDXK 0.001
2091 Endoplasmin HSP90B1 0.001
1422 Serine/threonine-protein kinase 6 AURKA 0.001
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.001
3379 Kinesin-like protein KIF11 KIF11 0.001
3456 Heat shock protein HSP 90-beta HSP90AB1 0.001
207 Glutathione synthetase GSS 0.001
5269 Glutathione synthetase gshB 0.001
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.001
3822 Actin, alpha skeletal muscle ACTA1 0.001
509 Thymidine kinase TK 0.0009
570 Thymidine kinase TK 0.0009
2559 Thymidine kinase TK 0.0009
3430 Thymidine kinase tdk 0.0009
3518 Thymidine kinase TK 0.0009
5301 Thymidine kinase tdk 0.0009
5771 Thymidine kinase ORF36 0.0009
7009 Thymidine kinase ORF36 0.0009
504 Mast/stem cell growth factor receptor KIT 0.0009
1721 Glycogen synthase kinase-3 beta GSK3B 0.0009
5682 Ribonuclease pancreatic RNASE1 0.0008
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0008
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0008
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0008
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