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DB03223 - Diphthamide


Identification
Name Diphthamide
Accession Number DB03223 (EXPT01142)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 297.3534
Groups experimental
Monoisotopic Weight 297.180089627
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Elongation factor 2
Name Elongation factor 2
Gene Name EEF2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.6652

Predictions


Id Partner name Gene Name Score
6792 Poly [ADP-ribose] polymerase 15 PARP15 0.1123
6791 Hypothetical exotoxin A toxA 0.1123
3404 Exotoxin A eta 0.0978
6552 Poly [ADP-ribose] polymerase 3 PARP3 0.0901
4593 ADP compounds hydrolase nudE nudE 0.0562
2460 ADP-ribose pyrophosphatase nudF 0.0489
4349 ADP-ribose pyrophosphatase ndx4 0.0489
3725 Lactaldehyde reductase fucO 0.0489
3108 CDP-glucose 4,6-dehydratase rfbG 0.0489
4037 Hypothetical protein GPX1 0.0451
4297 Hypothetical protein SP_1951 0.0451
4521 Hypothetical protein BC_2969 0.0451
4540 Hypothetical protein TM_1070 0.0451
4555 Hypothetical protein MT1739 0.0451
4569 Hypothetical protein mshD 0.0451
4578 Hypothetical protein PA3270 0.0451
4747 Hypothetical protein PA3967 0.0451
5177 Hypothetical protein TM_0096 0.0451
5194 Hypothetical protein PA1204 0.0451
5240 Hypothetical protein Rv2991 0.0451
5370 Hypothetical protein TM_1158 0.0451
5710 Hypothetical protein Tb927.5.1360 0.0451
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0407
2769 P-hydroxybenzoate hydroxylase pobA 0.0407
2809 P-hydroxybenzoate hydroxylase pobA 0.0407
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0385
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0385
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0385
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0385
3197 GDP-mannose mannosyl hydrolase nudD 0.017
5630 ADP-ribosylation factor-like protein 5A ARL5A 0.017
5618 ADP-ribosylation factor 4 ARF4 0.017
5628 Probable GTPase engC rsgA 0.017
1882 Ras-related C3 botulinum toxin substrate 1 RAC1 0.017
2170 Transforming protein RhoA RHOA 0.017
3366 GTP-binding protein engA der 0.017
5627 GDP-mannose 4,6-dehydratase gca 0.017
5624 GTPase rab6 0.017
3396 Elongation factor Tu tufA 0.0148
5621 Elongation factor Tu tuf 0.0148
3170 Elongation factor Tu-B tufB 0.0148
3335 Probable GTP-binding protein engB engB 0.0148
3115 Ras-related protein Rab-9 RAB9A 0.0148
3270 Elongation factor G fusA 0.0148
3354 Ras-related protein Rap-2a RAP2A 0.0148
5619 GDP-mannose 4,6 dehydratase GMDS 0.0148
3261 Signal recognition particle protein ffh 0.0148
3107 Putative GTP pyrophosphokinase relA 0.0148
6556 Elongation factor Tu GTP-binding domain-containing protein 1 EFTUD1 0.0137
6750 ADP-ribosylation factor 6 ARF6 0.0137
6447 Guanine nucleotide-binding protein G(t) subunit alpha-1 GNAT1 0.0137
2521 Cell division protein ftsZ ftsZ 0.0137
3301 Cell division protein ftsZ ftsZ 0.0137
1758 GTPase HRas HRAS 0.0123
1596 Protein-glutamine gamma-glutamyltransferase 2 TGM2 0.012
6316 ADP-ribosylation factor 1 ARF1 0.0115
2339 Protein-glutamine gamma-glutamyltransferase E TGM3 0.0114
3978 Adenylosuccinate synthetase isozyme 1 ADSSL1 0.0109
2632 Adenylosuccinate synthetase purA 0.0107
3323 Adenylosuccinate synthetase purA 0.0107
3975 Adenylosuccinate synthetase ADSS 0.0107
4598 Adenylosuccinate synthetase Adss 0.0107
6817 Adenylosuccinate synthetase purA 0.0107
5626 Nucleoside diphosphate kinase B NME2 0.0096
5294 Nucleoside diphosphate kinase A NME1 0.0092
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