DT-Web

DB01632 - Alpha-Phosphoribosylpyrophosphoric Acid


Identification
Name Alpha-Phosphoribosylpyrophosphoric Acid
Accession Number DB01632 (EXPT02663)
Type small molecule
Description The key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 390.0696
Groups experimental
Monoisotopic Weight 389.95181466
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Hypoxanthine-guanine phosphoribosyltransferase, putative
Name Hypoxanthine-guanine phosphoribosyltransferase, putative
Gene Name HGPRTase
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.7917
Adenine phosphoribosyltransferase
Name Adenine phosphoribosyltransferase
Gene Name APRT
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.8118
Anthranilate phosphoribosyltransferase
Name Anthranilate phosphoribosyltransferase
Gene Name trpD
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.7504
Hypoxanthine-guanine phosphoribosyltransferase
Name Hypoxanthine-guanine phosphoribosyltransferase
Gene Name HPRT1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.0711
Orotate phosphoribosyltransferase
Name Orotate phosphoribosyltransferase
Gene Name pyrE
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7495
Uridine-cytidine kinase-like 1
Name Uridine-cytidine kinase-like 1
Gene Name UCKL1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available

Predictions


Id Partner name Gene Name Score
3683 Purine nucleoside phosphorylase deoD-type deoD 0.1573
3680 Dihydroorotate dehydrogenase A pyrDA 0.1399
2775 Dihydroorotate dehydrogenase pyrD 0.136
2646 Dihydroorotase pyrC 0.1179
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0812
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0809
3799 Hypoxanthine phosphoribosyltransferase hpt 0.0661
3719 Inosine-5'-monophosphate dehydrogenase guaB 0.0657
2164 Multidrug resistance-associated protein 4 ABCC4 0.0611
3978 Adenylosuccinate synthetase isozyme 1 ADSSL1 0.0419
2632 Adenylosuccinate synthetase purA 0.041
3323 Adenylosuccinate synthetase purA 0.041
3975 Adenylosuccinate synthetase ADSS 0.041
4598 Adenylosuccinate synthetase Adss 0.041
6817 Adenylosuccinate synthetase purA 0.041
1405 Thiopurine S-methyltransferase TPMT 0.0408
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0383
3947 Xanthine dehydrogenase/oxidase XDH 0.0323
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0299
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0299
4752 Peroxisomal trans-2-enoyl-CoA reductase PECR 0.0299
1152 Glycogen phosphorylase, muscle form PYGM 0.0293
6288 Low molecular weight phosphotyrosine protein phosphatase ACP1 0.0263
4031 Glutathione S-transferase A1 GSTA1 0.0257
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0255
4606 Purine trans deoxyribosylase ptd 0.0244
4692 A/G-specific adenine glycosylase mutY 0.0243
896 Glutathione S-transferase Mu 1 GSTM1 0.0233
1958 S-methyl-5-thioadenosine phosphorylase MTAP 0.0233
3679 MTA/SAH nucleosidase mtnN 0.0229
3932 Glutathione S-transferase A2 GSTA2 0.0226
851 5'-AMP-activated protein kinase subunit beta-2 PRKAB2 0.0212
388 AMP deaminase 1 AMPD1 0.0212
775 Acetyl-CoA carboxylase 2 ACACB 0.0209
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0179
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0179
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0179
297 Adenylate cyclase type 1 ADCY1 0.0179
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0175
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0175
6171 Solute carrier family 28 member 3 SLC28A3 0.0173
2684 Histidine triad nucleotide-binding protein 1 HINT1 0.017
2264 Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase cobT 0.0167
1291 cAMP response element-binding protein CREB1 0.0167
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0163
2149 Angiogenin ANG 0.0161
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0155
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0152
6021 Adenosine kinase ADK 0.0147
2383 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0146
2937 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0146
4620 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0146
6594 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0146
6609 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0146
6646 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0146
2757 Inorganic pyrophosphatase ppa 0.0146
6238 Inorganic pyrophosphatase ppa 0.0146
6968 Inorganic pyrophosphatase PPA1 0.0146
6020 Aldehyde oxidase AOX1 0.0141
4198 Fructose-1,6-bisphosphatase 1 FBP1 0.014
4533 Glyoxalase family protein BC_1747 0.0138
6136 Multidrug resistance-associated protein 5 ABCC5 0.0134
2755 Hypoxanthine-guanine-xanthine phosphoribosyltransferase LACZ 0.013
4553 Bifunctional adenosylcobalamin biosynthesis protein cobU cobU 0.013
2647 RNA-directed RNA polymerase P2 0.0128
3583 6-phosphogluconolactonase pgl 0.0127
10 Glycogen phosphorylase, liver form PYGL 0.0127
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0126
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0119
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0119
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0119
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0117
3010 Regulatory protein blaR1 blaR1 0.0116
2727 S-adenosylmethionine synthetase metK 0.0112
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0112
2885 Carboxyethyl-arginine beta-lactam-synthase bls 0.011
4600 Malonamidase E2 Not Available 0.0109
2717 Folylpolyglutamate synthase fgs 0.0107
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0103
4545 Molybdopterin-converting factor subunit 2 moaE 0.0103
4037 Hypothetical protein GPX1 0.0103
4297 Hypothetical protein SP_1951 0.0103
4521 Hypothetical protein BC_2969 0.0103
4540 Hypothetical protein TM_1070 0.0103
4555 Hypothetical protein MT1739 0.0103
4569 Hypothetical protein mshD 0.0103
4578 Hypothetical protein PA3270 0.0103
4747 Hypothetical protein PA3967 0.0103
5177 Hypothetical protein TM_0096 0.0103
5194 Hypothetical protein PA1204 0.0103
5240 Hypothetical protein Rv2991 0.0103
5370 Hypothetical protein TM_1158 0.0103
5710 Hypothetical protein Tb927.5.1360 0.0103
4538 Hypothetical protein VC1899 VC_1899 0.0103
4536 Transcriptional regulator, IclR family TM_0065 0.0103
4524 Mannose-6-phosphate isomerase yvyI 0.0103
4522 Arginine N-succinyltransferase subunit alpha astA 0.0103
4547 Iron binding protein FbpA fbpA 0.0103
4106 Guanylate kinase GUK1 0.0103
4516 Guanylate kinase gmk 0.0103
4548 Gyrase B gyrB 0.0103
4546 Aminotransferase, putative TM_1131 0.0103
4527 Putative hydrolase ycdX ycdX 0.0103
658 Para-aminobenzoate synthase component 1 pabB 0.0103
2501 Protein ygbM ygbM 0.0103
4514 Citrate lyase beta subunit-like protein citE 0.0103
4781 Citrate lyase beta subunit-like protein DR_1240 0.0103
4526 Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein TM_1223 0.0103
4535 Glutaconyl-CoA decarboxylase subunit alpha gcdA 0.0103
4529 Oxalate decarboxylase oxdC oxdC 0.0103
4515 Peripheral plasma membrane protein CASK CASK 0.0103
2428 Thiamine-phosphate pyrophosphorylase thiE 0.0099
6142 Solute carrier family 22 member 8 SLC22A8 0.0098
6395 Myosin-14 MYH14 0.0096
4496 C-terminal-binding protein 1 CTBP1 0.0095
3261 Signal recognition particle protein ffh 0.0091
4517 Probable butyrate kinase 2 buk2 0.0091
4542 Glutaminase 1 glsA1 0.0091
4544 Glutaminase 1 glsA1 0.0091
4528 Phenazine biosynthesis protein PhzD phzD1 0.009
2929 (S)-2-haloacid dehalogenase dhlB 0.009
2995 (S)-2-haloacid dehalogenase Not Available 0.009
3759 Glutathione S-transferase gst 0.009
4541 Glutathione S-transferase GST 0.009
3237 Beta-lactamase OXA-2 bla 0.009
56 Delta-aminolevulinic acid dehydratase ALAD 0.009
2356 Delta-aminolevulinic acid dehydratase hemB 0.009
3613 Delta-aminolevulinic acid dehydratase hemB 0.009
3674 Delta-aminolevulinic acid dehydratase hemB 0.009
4532 Gephyrin GPHN 0.009
2230 Catalase CAT 0.0086
3249 Catalase katA 0.0086
3625 Catalase katA 0.0086
4539 Catalase katA 0.0086
4941 Catalase katB 0.0086
3467 Methylglyoxal synthase mgsA 0.0084
5682 Ribonuclease pancreatic RNASE1 0.0084
5294 Nucleoside diphosphate kinase A NME1 0.0083
4531 Putative ketoacyl reductase actIII 0.0083
2525 3-phosphoshikimate 1-carboxyvinyltransferase aroA 0.008
3201 3-phosphoshikimate 1-carboxyvinyltransferase aroA 0.008
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0077
4534 Cytohesin-2 CYTH2 0.0076
2688 Peptide deformylase def 0.0075
2708 Peptide deformylase def 0.0075
3004 Peptide deformylase def 0.0075
4337 Peptide deformylase def 0.0075
4338 Peptide deformylase def 0.0075
5368 Peptide deformylase def 0.0075
5371 Peptide deformylase def 0.0075
6375 Peptide deformylase def 0.0075
6378 Peptide deformylase def 0.0075
6379 Peptide deformylase def 0.0075
6776 Peptide deformylase def 0.0075
6900 Peptide deformylase def 0.0075
2548 Subtilisin Carlsberg apr 0.0072
760 Fibroblast growth factor 1 FGF1 0.0062
810 Heme oxygenase 1 HMOX1 0.0062
3391 Heme oxygenase 1 pbsA1 0.0062
3027 Streptavidin Not Available 0.006
500 Monocarboxylate transporter 4 SLC16A3 0.0058
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0056
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0056
4992 Cytochrome c peroxidase Not Available 0.0056
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0055
2300 Lysozyme E 0.0055
3633 Lysozyme R 0.0055
5597 Lysozyme 17 0.0055
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0055
4695 UPF0124 protein yfiH yfiH 0.0055
5590 N utilization substance protein B homolog nusB 0.0055
5588 Cell division protein FtsY TM_0570 0.0055
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0055
5587 Iron(III)-binding periplasmic protein fbpA 0.0055
5591 Complement component C8 gamma chain C8G 0.0055
5582 Regulator of transcription; stringent starvation protein A sspA 0.0055
2838 Ribose-5-phosphate isomerase A rpiA 0.0055
2952 Ribose-5-phosphate isomerase A rpiA 0.0055
5595 Ribose-5-phosphate isomerase A rpiA 0.0055
5593 Transferase Not Available 0.0055
4238 50S ribosomal protein L4 rplD 0.0055
5578 50S ribosomal protein L4 rplD 0.0055
6173 50S ribosomal protein L4 rplD 0.0055
6219 50S ribosomal protein L4 rplD 0.0055
5581 Beta-fructosidase bfrA 0.0055
5060 Intron-associated endonuclease 1 ITEVIR 0.0055
4375 Glutamine synthetase 1 glnA1 0.0055
5600 Pyruvate decarboxylase pdc 0.0055
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0055
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0055
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.0055
5575 Short tail fiber protein 12 0.0055
5580 Hexon protein PII 0.0055
5574 Invasin YPTB1668 0.0055
76 Nitric-oxide synthase, brain NOS1 0.0053
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0051
3729 Citrate synthase gltA 0.0051
4575 Citrate synthase cit 0.0051
4580 Citrate synthase gltA 0.0051
5328 Prostaglandin F synthase Tb11.02.2310 0.0051
3132 Tryptophan synthase alpha chain trpA 0.005
6568 Tryptophan synthase alpha chain trpA 0.005
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.0049
5006 RNASE4 protein RNASE4 0.0048
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0048
2555 Pol polyprotein pol 0.0048
3242 Pol polyprotein gag-pol 0.0048
3471 Pol polyprotein gag-pro-pol 0.0048
5256 Pol polyprotein pol 0.0048
6469 Pol polyprotein gag-pol 0.0048
6565 Pol polyprotein Not Available 0.0048
2521 Cell division protein ftsZ ftsZ 0.0048
3301 Cell division protein ftsZ ftsZ 0.0048
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0047
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0047
857 Malate dehydrogenase, mitochondrial MDH2 0.0046
2603 Beta-lactamase II blm 0.0045
1123 Eosinophil cationic protein RNASE3 0.0044
2697 Uridine-cytidine kinase 2 UCK2 0.0044
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.0043
2942 Sialidase nanH 0.0043
3546 Sialidase nedA 0.0043
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.0042
3486 Fumarate hydratase class II fumC 0.0042
2452 Tryptophanyl-tRNA synthetase trpS 0.0042
2286 Isocitrate dehydrogenase [NADP] icd 0.0042
2302 Isocitrate dehydrogenase [NADP] icd 0.0042
2771 Isocitrate dehydrogenase [NADP] icd 0.0042
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0042
332 Beta-lactamase blaZ 0.0041
2478 Beta-lactamase ampC 0.0041
2613 Beta-lactamase ampC 0.0041
2635 Beta-lactamase ampC 0.0041
2700 Beta-lactamase penP 0.0041
5445 Beta-lactamase blaB 0.0041
6019 Beta-lactamase SHV-7 0.0041
6701 Beta-lactamase cphA 0.0041
411 Glycine N-methyltransferase GNMT 0.0041
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.004
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.004
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0039
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0039
357 Carbonic anhydrase 2 CA2 0.0039
5579 Carboxypeptidase B CPB1 0.0037
3384 Macrophage migration inhibitory factor MIF 0.0036
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0032
822 Aldose reductase AKR1B1 0.0029
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0027
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0024
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