DT-Web

DB07780 - FARNESYL DIPHOSPHATE


Identification
Name FARNESYL DIPHOSPHATE
Accession Number DB07780
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 382.3261
Groups experimental
Monoisotopic Weight 382.131026274
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit
Name Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit
Gene Name FNTA
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 2.1202
Protein farnesyltransferase subunit beta
Name Protein farnesyltransferase subunit beta
Gene Name FNTB
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 2.0761
GTPase KRas
Name GTPase KRas
Gene Name KRAS
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.1415
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Name 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Gene Name ispF
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.1411
Farnesyl pyrophosphate synthetase
Name Farnesyl pyrophosphate synthetase
Gene Name FDPS
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.2956
Undecaprenyl pyrophosphate synthetase
Name Undecaprenyl pyrophosphate synthetase
Gene Name uppS
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.7722
Lantibiotic nisin-Z
Name Lantibiotic nisin-Z
Gene Name nisZ
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.7129
Geranylgeranyl pyrophosphate synthetase
Name Geranylgeranyl pyrophosphate synthetase
Gene Name GGPS1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.9852
Short-chain Z-isoprenyl diphosphate synthetase
Name Short-chain Z-isoprenyl diphosphate synthetase
Gene Name Rv1086
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.8068
Geranylgeranyl transferase type-2 subunit alpha
Name Geranylgeranyl transferase type-2 subunit alpha
Gene Name RABGGTA
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.9895
Geranylgeranyl transferase type-2 subunit beta
Name Geranylgeranyl transferase type-2 subunit beta
Gene Name RABGGTB
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.9899

Predictions


Id Partner name Gene Name Score
1994 Geranylgeranyl transferase type-1 subunit beta PGGT1B 0.4778
6571 Guanine nucleotide-binding protein G(T) subunit gamma-T1 GNGT1 0.2617
6573 Phosducin PDC 0.2613
6572 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 GNB1 0.2612
6577 Rab proteins geranylgeranyltransferase component A 1 CHM 0.2611
6548 4-hydroxy-3-methylbut-2-enyl diphosphate reductase ispH 0.1989
3188 IspD/ispF bifunctional enzyme [Includes: 2-C-methyl-D-erythritol 4- phosphate cytidylyltransferase ispDF 0.1758
6540 Prenyltransferase Not Available 0.1528
6597 Mevalonate kinase MVK 0.1463
2383 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.1411
2937 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.1411
4620 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.1411
6609 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.1411
6646 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.1411
6368 Dehydrosqualene synthase crtM 0.1174
6547 Isopentenyl-diphosphate Delta-isomerase 1 IDI1 0.0696
6647 Geranyltranstransferase (Farnesyldiphosphate synthase) ispA 0.0522
862 Multidrug resistance-associated protein 1 ABCC1 0.0474
2756 Geranyltranstransferase ispA 0.042
6056 Receptor-type tyrosine-protein phosphatase epsilon PTPRE 0.0369
1376 Tyrosine-protein phosphatase non-receptor type 4 PTPN4 0.0369
290 Prostaglandin G/H synthase 2 PTGS2 0.0349
4284 Pentaerythritol tetranitrate reductase onr 0.0348
6055 Receptor-type tyrosine-protein phosphatase S PTPRS 0.0322
6057 V-type proton ATPase catalytic subunit A ATP6V1A 0.0301
6589 Delta-hemolysin hld 0.0275
6424 Light-harvesting protein B-800/820 beta chain Not Available 0.0275
6586 Protein S100-G S100G 0.0275
6423 Light-harvesting protein B-800/820 alpha chain Not Available 0.0275
6587 Rubredoxin rub 0.0275
6591 ATP synthase C chain atpH 0.0275
6585 HLA class I histocompatibility antigen, B-27 alpha chain HLA-B 0.0274
4718 Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial CLPP 0.0274
6588 Methionyl-tRNA formyltransferase fmt 0.0274
6592 Probable L-ascorbate-6-phosphate lactonase ulaG ulaG 0.0274
6593 Immunoglobulin G-binding protein G spg 0.0274
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0239
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0239
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0239
6493 Cytochrome c oxidase subunit 6C COX6C 0.0239
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0239
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0239
6279 Beta-2-microglobulin B2M 0.0239
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0239
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0239
6319 Respiratory nitrate reductase 1 gamma chain narI 0.0239
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0239
6559 Cytochrome c oxidase subunit 2 ctaC 0.0239
6669 Cytochrome c oxidase subunit 2 ctaC 0.0239
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0239
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0239
3175 Glutamate--cysteine ligase gshA 0.0239
6318 Respiratory nitrate reductase 1 beta chain narH 0.0239
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0239
6558 Cytochrome c oxidase subunit 1 ctaD 0.0239
6317 Respiratory nitrate reductase 1 alpha chain narG 0.0238
6427 Light-harvesting protein B-800/850 alpha chain Not Available 0.0221
6533 Light-harvesting protein B-800/850 alpha chain A1 0.0221
6428 Light-harvesting protein B-800/850 beta chain Not Available 0.022
2132 Protein S100-B S100B 0.0184
6351 Photosynthetic reaction center cytochrome c subunit pufC 0.0181
6353 Reaction center protein L chain pufL 0.0181
6454 Reaction center protein L chain pufL 0.0181
6683 Reaction center protein L chain pufL 0.0181
6354 Reaction center protein M chain pufM 0.0181
6455 Reaction center protein M chain pufM 0.0181
6684 Reaction center protein M chain pufM 0.0181
6352 Reaction center protein H chain puhA 0.0181
6456 Reaction center protein H chain puhA 0.0181
6682 Reaction center protein H chain puhA 0.0181
3027 Streptavidin Not Available 0.016
309 Antithrombin-III SERPINC1 0.0145
5682 Ribonuclease pancreatic RNASE1 0.0137
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0116
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