DT-Web

DB04099 - Deamido-Nad+


Identification
Name Deamido-Nad+
Accession Number DB04099 (EXPT01234)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 665.4178
Groups experimental
Monoisotopic Weight 665.100962248
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


NH(3)-dependent NAD(+) synthetase
Name NH(3)-dependent NAD(+) synthetase
Gene Name nadE
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.0926
Nicotinamide mononucleotide adenylyltransferase 1
Name Nicotinamide mononucleotide adenylyltransferase 1
Gene Name NMNAT1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.0885
Nicotinate-nucleotide adenylyltransferase
Name Nicotinate-nucleotide adenylyltransferase
Gene Name nadD
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.017
Nicotinamide mononucleotide adenylyltransferase 3
Name Nicotinamide mononucleotide adenylyltransferase 3
Gene Name NMNAT3
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.123
NH(3)-dependent NAD(+) synthetase
Name NH(3)-dependent NAD(+) synthetase
Gene Name nadE
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.0926
NH(3)-dependent NAD(+) synthetase
Name NH(3)-dependent NAD(+) synthetase
Gene Name nadE
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.0926

Predictions


Id Partner name Gene Name Score
4469 Nicotinate-nucleotide adenylyltransferase nadD 1.017
4491 DNA ligase, NAD-dependent ligA 0.2334
2922 Glycerol kinase glpK 0.2255
2290 ADP-ribosyl cyclase 2 BST1 0.2236
4775 PROBABLE LIGNIN PEROXIDASE LIPJ lipJ 0.1249
2885 Carboxyethyl-arginine beta-lactam-synthase bls 0.1183
4774 NTPase P4 Not Available 0.1087
4776 CarA carA 0.1087
4655 Adenylate cyclase cyaC 0.1002
4759 Adenylate cyclase cyaB2 0.1002
2532 Pantoate--beta-alanine ligase panC 0.0947
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0847
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0847
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0847
2756 Geranyltranstransferase ispA 0.0752
2632 Adenylosuccinate synthetase purA 0.0752
3323 Adenylosuccinate synthetase purA 0.0752
3975 Adenylosuccinate synthetase ADSS 0.0752
4598 Adenylosuccinate synthetase Adss 0.0752
6817 Adenylosuccinate synthetase purA 0.0752
2586 Isopentenyl-diphosphate Delta-isomerase idi 0.0679
5187 Isopentenyl-diphosphate delta-isomerase fni 0.0679
5199 Isopentenyl-diphosphate delta-isomerase fni 0.0679
2251 Thymidylate kinase tmk 0.0615
2254 Thymidylate kinase DTYMK 0.0615
3522 Thymidylate kinase tmk 0.0615
2427 Ferrichrome-iron receptor fhuA 0.0525
2383 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0313
2937 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0313
4620 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0313
6594 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0313
6609 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0313
6646 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0313
2757 Inorganic pyrophosphatase ppa 0.0312
6238 Inorganic pyrophosphatase ppa 0.0312
6968 Inorganic pyrophosphatase PPA1 0.0312
4553 Bifunctional adenosylcobalamin biosynthesis protein cobU cobU 0.0272
2755 Hypoxanthine-guanine-xanthine phosphoribosyltransferase LACZ 0.0272
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0272
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0272
2647 RNA-directed RNA polymerase P2 0.0272
2149 Angiogenin ANG 0.0251
3010 Regulatory protein blaR1 blaR1 0.0251
4600 Malonamidase E2 Not Available 0.0236
2727 S-adenosylmethionine synthetase metK 0.0226
2717 Folylpolyglutamate synthase fgs 0.0226
2428 Thiamine-phosphate pyrophosphorylase thiE 0.0212
6395 Myosin-14 MYH14 0.0201
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.018
5294 Nucleoside diphosphate kinase A NME1 0.0171
4428 Redox-sensing transcriptional repressor rex rex 0.0169
4449 ADP-ribosyltransferase Not Available 0.0169
4495 3-oxoacyl-(Acyl carrier protein) reductase TM_1169 0.0169
4423 Levodione reductase lvr 0.0169
4505 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase bphB 0.0169
4443 Quinate/shikimate dehydrogenase ydiB 0.0169
4472 Glucose 1-dehydrogenase Not Available 0.0169
4448 L-2-hydroxyisocaproate dehydrogenase Not Available 0.0169
4435 L-aspartate dehydrogenase nadX 0.0169
4418 AGR_L_3209p AGR_L_3209 0.0169
4500 L-lactate dehydrogenase 2 ldh2 0.0169
2350 3-isopropylmalate dehydrogenase leuB 0.0169
3092 3-isopropylmalate dehydrogenase leuB 0.0169
4456 Inorganic polyphosphate/ATP-NAD kinase ppnK 0.0169
4475 Hypothetical protein Rv0046c/MT0052 ino1 0.0169
4455 Glycerol dehydrogenase gldA 0.0169
4506 Myo-inositol-1-phosphate synthase-related protein TM_1419 0.0169
3735 NAD(P) transhydrogenase subunit alpha part 1 pntAA 0.0169
4414 Dehydrogenase TT_P0035 0.0169
4446 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase Not Available 0.0169
4466 Glutathione-independent formaldehyde dehydrogenase fdhA 0.0169
4471 CDP-D-glucose-4,6-dehydratase ascB 0.0169
4507 Alanine dehydrogenase ald 0.0169
4497 Benzyl alcohol dehydrogenase xylB 0.0169
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.0169
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.0169
3729 Citrate synthase gltA 0.0169
4575 Citrate synthase cit 0.0169
4580 Citrate synthase gltA 0.0169
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0169
3726 D-3-phosphoglycerate dehydrogenase serA 0.0169
4291 D-3-phosphoglycerate dehydrogenase serA 0.0169
4487 Transcriptional regulator nadR nadR 0.0169
4502 Formate dehydrogenase Not Available 0.0169
3381 Alcohol dehydrogenase Not Available 0.0169
4508 Alcohol dehydrogenase adhA 0.0169
4451 Vip2Ac vip2Ac 0.0169
4447 Hypothetical protein yhfP yhfP 0.0169
4467 Alpha-glucosidase, putative TM_0752 0.0168
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0156
4486 Phenol 2-hydroxylase component B pheA2 0.0147
3615 Dihydrodipicolinate reductase dapB 0.0147
3618 Dihydrodipicolinate reductase dapB 0.0147
4462 Dihydrodipicolinate reductase dapB 0.0147
6698 Dehydrogenase/reductase SDR family member 4-like 2 DHRS4L2 0.0147
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.0147
3059 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase fabG3 0.0147
4503 NADPH-flavin oxidoreductase frp 0.0147
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0147
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0147
4509 Acetoin(diacetyl) reductase budC 0.0147
2018 Deoxyhypusine synthase DHPS 0.0147
126 D-lactate dehydrogenase dld 0.0147
3545 D-lactate dehydrogenase Not Available 0.0147
4510 D-lactate dehydrogenase ldhA 0.0147
4427 TDP-glucose-4,6-dehydratase desIV 0.0147
4498 Ornithine cyclodeaminase PP3533 0.0147
2424 L-lactate dehydrogenase ldh 0.0147
2641 L-lactate dehydrogenase Not Available 0.0147
4437 L-lactate dehydrogenase ldh 0.0147
4442 L-lactate dehydrogenase ldh 0.0147
3177 dTDP-glucose 4,6-dehydratase rfbB 0.0147
4499 dTDP-glucose 4,6-dehydratase rmlB 0.0147
1199 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 ART1 0.0147
4496 C-terminal-binding protein 1 CTBP1 0.0147
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.0147
3081 3-dehydroquinate synthase aroB 0.0147
4439 Ferredoxin reductase bphA4 0.0147
2336 2,3-diketo-L-gulonate reductase dlgD 0.0147
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.0147
4477 Dihydrolipoyl dehydrogenase lpdV 0.0147
5077 Dihydrolipoyl dehydrogenase Not Available 0.0147
5117 Dihydrolipoyl dehydrogenase lpd 0.0147
4482 UDP-galactose 4-epimerase galE 0.0147
2881 Gamma-aminobutyraldehyde dehydrogenase prr 0.0147
4450 Iota toxin component Ia Not Available 0.0147
2538 6-phospho-beta-glucosidase bglT bglT 0.0147
2393 Maltose-6'-phosphate glucosidase glvA 0.0147
2967 CDP-paratose 2-epimerase rfbE 0.0147
2591 Urocanate hydratase hutU 0.0147
2507 Diphtheria toxin Not Available 0.0147
711 UDP-glucose 6-dehydrogenase UGDH 0.0135
3672 UDP-glucose 6-dehydrogenase hasB 0.0135
2683 Mono-ADP-ribosyltransferase C3 C3 0.0135
4440 NADH peroxidase npr 0.0135
4343 Alpha-glucosidase aglA 0.0135
4504 WbpP Not Available 0.0135
3367 GDP-mannose 6-dehydrogenase algD 0.0135
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0135
4318 Siroheme synthase cysG 0.0135
2799 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Not Available 0.0135
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0135
816 Biliverdin reductase A BLVRA 0.0135
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0135
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0135
597 Dihydropteridine reductase QDPR 0.0128
328 Sorbitol dehydrogenase SORD 0.0128
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0128
646 Malate dehydrogenase, cytoplasmic MDH1 0.0128
396 Alcohol dehydrogenase 4 ADH4 0.0128
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0128
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0128
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0128
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0128
2617 Nitric oxide synthase oxygenase nos 0.0128
2701 Nitric oxide synthase oxygenase nos 0.0128
3191 Histidinol dehydrogenase hisD 0.0128
2826 Glucose--fructose oxidoreductase gfo 0.0128
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0128
3070 Adenosylhomocysteinase AHCY 0.0128
4424 Adenosylhomocysteinase PFE1050w 0.0128
6278 Adenosylhomocysteinase ahcY 0.0128
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0128
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0128
63 Malate dehydrogenase mdh 0.0126
2329 Malate dehydrogenase mdh 0.0126
3445 Malate dehydrogenase mdh 0.0126
4420 Malate dehydrogenase mdh 0.0126
4438 Malate dehydrogenase mdh 0.0126
4476 Mannitol dehydrogenase mtlD 0.0125
12 Alcohol dehydrogenase class 3 ADH5 0.0123
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0122
77 L-lactate dehydrogenase B chain LDHB 0.0122
327 Glutathione reductase gor 0.0122
5110 Glutathione reductase GR2 0.0122
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0122
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0122
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0122
473 L-lactate dehydrogenase A chain LDHA 0.0118
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0118
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0118
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0118
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0118
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0118
2286 Isocitrate dehydrogenase [NADP] icd 0.0118
2302 Isocitrate dehydrogenase [NADP] icd 0.0118
2771 Isocitrate dehydrogenase [NADP] icd 0.0118
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0115
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0115
2762 UDP-glucose 4-epimerase GALE 0.0114
3461 UDP-glucose 4-epimerase galE 0.0114
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0111
611 Retinal dehydrogenase 1 ALDH1A1 0.0104
569 Retinal dehydrogenase 2 ALDH1A2 0.0104
251 Alcohol dehydrogenase 1A ADH1A 0.0103
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0103
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0101
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.01
444 Alcohol dehydrogenase 1B ADH1B 0.0098
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0096
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0096
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0096
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0096
714 Glutathione reductase, mitochondrial GSR 0.0093
517 Alcohol dehydrogenase 1C ADH1C 0.0089
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0089
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