DT-Web

DB03088 - Pyroglutamic Acid


Identification
Name Pyroglutamic Acid
Accession Number DB03088 (EXPT00247)
Type small molecule
Description A cyclized derivative of L-GLUTAMIC ACID. Elevated blood levels may be associated with problems of GLUTAMINE or GLUTATHIONE metabolism. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 129.114
Groups experimental
Monoisotopic Weight 129.042593095
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Vascular endothelial growth factor A
Name Vascular endothelial growth factor A
Gene Name VEGFA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.9358
Pancreatic alpha-amylase
Name Pancreatic alpha-amylase
Gene Name AMY2A
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 1.9474
Ig lambda-1 chain C regions
Name Ig lambda-1 chain C regions
Gene Name IGLC1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
RNASE4 protein
Name RNASE4 protein
Gene Name RNASE4
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.8368
Ig lambda chain V-II region MGC
Name Ig lambda chain V-II region MGC
Gene Name Not Available
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.9307
Trefoil factor 2
Name Trefoil factor 2
Gene Name TFF2
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
Cytochrome c2
Name Cytochrome c2
Gene Name cycA
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.0062
Disintegrin and metalloproteinase domain-containing protein 28
Name Disintegrin and metalloproteinase domain-containing protein 28
Gene Name ADAM28
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.9134
Glycoside hydrolase
Name Glycoside hydrolase
Gene Name Not Available
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.8984
Dissimilatory copper-containing nitrite reductase
Name Dissimilatory copper-containing nitrite reductase
Gene Name nir
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.8292
Glycoside hydrolase
Name Glycoside hydrolase
Gene Name Not Available
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.8984
Keratin-associated protein 5-2
Name Keratin-associated protein 5-2
Gene Name KRTAP5-2
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
Orexin
Name Orexin
Gene Name HCRT
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
Small inducible cytokine A8
Name Small inducible cytokine A8
Gene Name CCL8
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.9305
Cytochrome c'
Name Cytochrome c'
Gene Name Not Available
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score Not Available
Alpha-amylase 2B
Name Alpha-amylase 2B
Gene Name AMY2B
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
Angiogenin
Name Angiogenin
Gene Name ANG
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.8086
Chondroitinase B
Name Chondroitinase B
Gene Name cslB
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.3188
Salivary alpha-amylase
Name Salivary alpha-amylase
Gene Name AMY1A
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.3653

Enzymes


Pancreatic alpha-amylase
Name Pancreatic alpha-amylase
Gene Name AMY2A
Actions Not Available
References Not Available
DTHybrid score 1.9474

Predictions


Id Partner name Gene Name Score
2581 Chondroitinase AC cslA 0.1918
3603 Chlorocatechol 1,2-dioxygenase clcA 0.1363
3590 Alpha-lytic protease alpha-LP 0.1363
5377 Placenta growth factor PGF 0.1355
6607 Aggrecan core protein ACAN 0.1195
4830 Aldose 1-epimerase galM 0.1165
2485 Hyaluronate lyase SP_0314 0.0945
3172 Hyaluronate lyase hylB 0.0945
4622 Amylase Not Available 0.0921
2489 Lethal factor lef 0.0867
6703 Lethal factor lef 0.0867
2978 Maltogenic alpha-amylase amyM 0.0816
4669 Endo-1,4-beta-xylanase A xynA 0.0809
4715 Endo-1,4-beta-xylanase A xlnA 0.0809
5560 Endo-1,4-beta-xylanase A xynA 0.0809
5245 Endo-beta-1,4-xylanase Not Available 0.0795
5246 Xylanase Y BH2105 0.0795
5247 Endo-1,4-beta-xylanase Not Available 0.0792
5248 Endo-1,4-beta-xylanase xlnA 0.0792
5250 Endo-1,4-beta-xylanase xyl 0.0792
929 Maltase-glucoamylase, intestinal MGAM 0.0753
1016 Lysosomal alpha-glucosidase GAA 0.075
5696 Alginate lyase aly 0.0734
4819 Hydrolase Not Available 0.073
5249 Hydrolase Not Available 0.073
5436 Hydrolase Not Available 0.073
4808 Endoxylanase xynC 0.0692
3365 Beta-amylase spoII 0.0689
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0636
4416 Chondroitinase Not Available 0.0589
6230 A disintegrin and metalloproteinase with thrombospondin motifs 5 ADAMTS5 0.0576
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0572
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0572
2970 Matrix metalloproteinase-16 MMP16 0.0536
6847 Lactase-phlorizin hydrolase LCT 0.0508
1334 Tissue factor pathway inhibitor TFPI 0.0471
3221 Cytochrome c4 cc4 0.0436
1719 Heparanase HPSE 0.0414
2154 Neutrophil collagenase MMP8 0.041
2203 Macrophage metalloelastase MMP12 0.0399
2383 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0394
2937 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0394
4620 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0394
6594 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0394
6609 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0394
6646 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 0.0394
2757 Inorganic pyrophosphatase ppa 0.0393
6238 Inorganic pyrophosphatase ppa 0.0393
6968 Inorganic pyrophosphatase PPA1 0.0393
2058 P-selectin SELP 0.0373
3583 6-phosphogluconolactonase pgl 0.037
1507 Cytochrome c CYCS 0.0367
4553 Bifunctional adenosylcobalamin biosynthesis protein cobU cobU 0.0343
2755 Hypoxanthine-guanine-xanthine phosphoribosyltransferase LACZ 0.0342
2647 RNA-directed RNA polymerase P2 0.0342
309 Antithrombin-III SERPINC1 0.0329
4923 Cytochrome c3 DvMF_2499 0.0322
4945 Cytochrome c3 Not Available 0.0322
4949 Cytochrome c3 DVU_3171 0.0322
4968 Cytochrome c3 cytc3 0.0322
4997 Cytochrome c3 SO_2727 0.0322
5219 Cytochrome c3 cyd 0.0322
4948 Cytochrome c-553 Not Available 0.0322
4902 Nine-heme cytochrome c Ddes_2038 0.0322
3189 High-molecular-weight cytochrome c hmcA 0.0321
3010 Regulatory protein blaR1 blaR1 0.0316
5221 Cytochrome c3, 13 kDa Not Available 0.0308
5220 Split-Soret cytochrome c Ddes_2150 0.0308
3152 Cytochrome c'' cycA 0.0308
3700 Cytochrome c-552 precursor nrfA 0.0308
2129 Sucrase-isomaltase, intestinal SI 0.0305
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0298
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0298
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0298
4600 Malonamidase E2 Not Available 0.0298
2885 Carboxyethyl-arginine beta-lactam-synthase bls 0.0298
4386 Hemoglobin-like protein HbN glbN 0.0297
2727 S-adenosylmethionine synthetase metK 0.0285
2717 Folylpolyglutamate synthase fgs 0.0285
2720 Copper-containing nitrite reductase nirK 0.0284
4992 Cytochrome c peroxidase Not Available 0.0283
5446 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase HI_1679 0.0272
3781 Thiol:disulfide interchange protein dsbC precursor dsbC 0.0272
5449 Hypothetical gliding protein mglB 0.0272
5443 UPF0189 protein ymdB ymdB 0.0272
5440 UPF0067 protein yebR yebR 0.0272
4705 Manganese catalase Not Available 0.0272
5439 33 kDa chaperonin hslO 0.0272
5448 Ribonuclease Z rnz 0.0272
5447 Lethal(3)malignant brain tumor-like protein L3MBTL1 0.0272
5454 Internalin-A inlA 0.0272
4757 Cytochrome P450 2C9 CYP2C9 0.0271
3127 Nitrite reductase nirS 0.0268
3284 Nitrite reductase nirS 0.0268
2428 Thiamine-phosphate pyrophosphorylase thiE 0.0267
587 Serum albumin ALB 0.0264
5591 Complement component C8 gamma chain C8G 0.0264
5582 Regulator of transcription; stringent starvation protein A sspA 0.0264
2838 Ribose-5-phosphate isomerase A rpiA 0.0264
2952 Ribose-5-phosphate isomerase A rpiA 0.0264
5595 Ribose-5-phosphate isomerase A rpiA 0.0264
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0264
5590 N utilization substance protein B homolog nusB 0.0264
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0264
2300 Lysozyme E 0.0264
3633 Lysozyme R 0.0264
5597 Lysozyme 17 0.0264
5587 Iron(III)-binding periplasmic protein fbpA 0.0264
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0264
4238 50S ribosomal protein L4 rplD 0.0264
5578 50S ribosomal protein L4 rplD 0.0264
6173 50S ribosomal protein L4 rplD 0.0264
6219 50S ribosomal protein L4 rplD 0.0264
4695 UPF0124 protein yfiH yfiH 0.0264
5581 Beta-fructosidase bfrA 0.0264
5060 Intron-associated endonuclease 1 ITEVIR 0.0264
5588 Cell division protein FtsY TM_0570 0.0264
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0263
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0263
5575 Short tail fiber protein 12 0.0263
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.0263
5593 Transferase Not Available 0.0263
4375 Glutamine synthetase 1 glnA1 0.0263
5600 Pyruvate decarboxylase pdc 0.0263
5580 Hexon protein PII 0.0263
5574 Invasin YPTB1668 0.0263
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0257
6395 Myosin-14 MYH14 0.0253
4608 Putative cytochrome P450 SCO1207 0.0242
4963 Putative cytochrome P450 SCO2884 0.0242
6254 Putative cytochrome P450 SCO6998 0.0242
2714 Chorismate mutase aroH 0.0237
4611 Chorismate mutase aroG 0.0237
4498 Ornithine cyclodeaminase PP3533 0.0237
3274 Hydroxylamine reductase hcp 0.0237
4804 Hydroxylamine reductase hcp 0.0237
3356 Diaminopimelate decarboxylase lysA 0.0237
5450 Prolyl endopeptidase Pep pep 0.0236
3405 Quinohaemoprotein ethanol dehydrogenase type-1 qheDH 0.0233
4533 Glyoxalase family protein BC_1747 0.023
3132 Tryptophan synthase alpha chain trpA 0.023
6568 Tryptophan synthase alpha chain trpA 0.023
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.023
3729 Citrate synthase gltA 0.023
4575 Citrate synthase cit 0.023
4580 Citrate synthase gltA 0.023
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.023
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.023
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0229
5328 Prostaglandin F synthase Tb11.02.2310 0.0229
2555 Pol polyprotein pol 0.0229
3242 Pol polyprotein gag-pol 0.0229
3471 Pol polyprotein gag-pro-pol 0.0229
5256 Pol polyprotein pol 0.0229
6469 Pol polyprotein gag-pol 0.0229
6565 Pol polyprotein Not Available 0.0229
3480 Mannan endo-1,4-beta-mannosidase manA 0.0221
3399 Limonene-1,2-epoxide hydrolase limA 0.0218
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.0218
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0218
3462 Tyrosine-protein kinase transforming protein Abl ABL 0.0218
2603 Beta-lactamase II blm 0.0212
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.0212
2521 Cell division protein ftsZ ftsZ 0.0211
3301 Cell division protein ftsZ ftsZ 0.0211
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0211
5294 Nucleoside diphosphate kinase A NME1 0.0209
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0208
5180 L(+)-mandelate dehydrogenase mdlB 0.0206
3500 Putative family 31 glucosidase yicI yicI 0.0206
2286 Isocitrate dehydrogenase [NADP] icd 0.02
2302 Isocitrate dehydrogenase [NADP] icd 0.02
2771 Isocitrate dehydrogenase [NADP] icd 0.02
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.02
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.02
3486 Fumarate hydratase class II fumC 0.02
2942 Sialidase nanH 0.02
3546 Sialidase nedA 0.02
4411 DNA protection during starvation protein dps 0.0197
5423 UPF0010 protein HI1317 HI_1317 0.0197
3780 Lipoprotein nlpI precursor nlpI 0.0197
5424 Endonuclease VIII-like 1 NEIL1 0.0197
1615 Chymase CMA1 0.0197
577 Argininosuccinate lyase ASL 0.0195
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0192
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.0191
2597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] glmS 0.019
597 Dihydropteridine reductase QDPR 0.0188
2723 Cholera enterotoxin subunit B ctxB 0.0185
332 Beta-lactamase blaZ 0.0185
2478 Beta-lactamase ampC 0.0185
2613 Beta-lactamase ampC 0.0185
2635 Beta-lactamase ampC 0.0185
2700 Beta-lactamase penP 0.0185
5445 Beta-lactamase blaB 0.0185
6019 Beta-lactamase SHV-7 0.0185
6701 Beta-lactamase cphA 0.0185
365 Dihydrofolate reductase DHFR 0.0184
2381 Dihydrofolate reductase DFR1 0.0184
2833 Dihydrofolate reductase Not Available 0.0184
2931 Dihydrofolate reductase folA 0.0184
3544 Dihydrofolate reductase folA 0.0184
3682 Dihydrofolate reductase folA 0.0184
6642 Dihydrofolate reductase folA 0.0184
6756 Dihydrofolate reductase dfrA 0.0184
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0184
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0184
2697 Uridine-cytidine kinase 2 UCK2 0.0184
857 Malate dehydrogenase, mitochondrial MDH2 0.0183
1123 Eosinophil cationic protein RNASE3 0.0183
2452 Tryptophanyl-tRNA synthetase trpS 0.0183
5787 Angiopoietin-1 receptor TEK 0.0182
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0179
287 Beta-1,4-galactosyltransferase 1 B4GALT1 0.0177
5579 Carboxypeptidase B CPB1 0.0174
3164 Biotin synthase bioB 0.0173
3186 Soluble calcium-activated nucleotidase 1 CANT1 0.0172
3384 Macrophage migration inhibitory factor MIF 0.017
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0169
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0169
411 Glycine N-methyltransferase GNMT 0.0167
3814 Complement C1r subcomponent C1R 0.0161
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0157
3259 Autolysin lytA 0.0151
6016 Cytochrome P450 2C19 CYP2C19 0.0146
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0146
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0145
128 Adenine phosphoribosyltransferase APRT 0.0145
1654 Interleukin-1 beta IL1B 0.0145
844 Epidermal growth factor receptor EGFR 0.0145
1184 Interferon beta IFNB1 0.0139
3817 Complement C1q subcomponent subunit C C1QC 0.0138
3816 Complement C1q subcomponent subunit B C1QB 0.0138
3815 Complement C1q subcomponent subunit A C1QA 0.0138
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0137
494 Caspase-1 CASP1 0.0136
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0136
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0136
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0136
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0136
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.0135
5682 Ribonuclease pancreatic RNASE1 0.0132
822 Aldose reductase AKR1B1 0.0131
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.013
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0128
275 Arachidonate 5-lipoxygenase ALOX5 0.0127
904 Glutathione S-transferase P GSTP1 0.0124
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0122
1374 Natriuretic peptides B NPPB 0.0122
1827 Gap junction alpha-1 protein GJA1 0.0121
1908 Vascular cell adhesion protein 1 VCAM1 0.0121
4666 Fucose-binding lectin PA-IIL lecB 0.0121
2372 Bifunctional tail protein 9 0.0121
22 30S ribosomal protein S4 rpsD 0.0117
6714 30S ribosomal protein S4 rpsD 0.0117
2077 Caspase-3 CASP3 0.0116
3689 Endoglucanase A celA 0.0115
5411 Slt-IIvB stxB2e 0.0115
5563 Galectin-2 LGALS2 0.0115
5046 Ecotin eco 0.0115
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0115
3009 Beta-glucanase Not Available 0.0115
5569 Endo-1,4-beta glucanase EngF engF 0.0115
1875 Pulmonary surfactant-associated protein D SFTPD 0.0115
5554 D-galactose-binding periplasmic protein mglB 0.0115
3741 D-galactose-binding periplasmic protein precursor mglB 0.0115
5553 Endoglucanase E1 Acel_0614 0.0115
3793 Aspartate ammonia-lyase aspA 0.0115
5562 Hexokinase Not Available 0.0115
4668 Laminarinase TM_0024 0.0115
3744 Endoglucanase SS precursor celS 0.0115
5568 Endoglucanase C307 celC307 0.0115
5559 Neopullulanase nplT 0.0115
4670 Cellulase B celB 0.0115
5570 Endoglucanase E-4 celD 0.0115
4667 BH0236 protein BH0236 0.0115
4671 Endoglucanase C cenC 0.0115
20 Prostaglandin G/H synthase 1 PTGS1 0.0114
65 Matrix metalloproteinase-9 Not Available 0.0112
140 30S ribosomal protein S9 rpsI 0.011
6719 30S ribosomal protein S9 rpsI 0.011
6725 30S ribosomal protein S9 rpsI 0.011
4512 Cytochrome P450 3A4 CYP3A4 0.0109
474 Acetylcholinesterase ACHE 0.0105
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0103
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0103
4509 Acetoin(diacetyl) reductase budC 0.01
1503 Galectin-7 LGALS7 0.01
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.01
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.01
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.01
5498 Maltoporin lamB 0.01
5561 Maltoporin lamB 0.01
5416 Coat protein VP1 Not Available 0.01
5176 YtnJ moxC 0.01
2705 Dimethyl sulfoxide reductase dmsA 0.01
3923 Cholinesterase BCHE 0.0099
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0097
862 Multidrug resistance-associated protein 1 ABCC1 0.0097
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0092
2531 Alpha-amylase amyE 0.0092
2948 Alpha-amylase amy 0.0092
3169 Alpha-amylase Not Available 0.0092
3547 Enterotoxin type B entB 0.0092
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0092
3091 Maltodextrin phosphorylase malP 0.0092
2606 Neopullulanase 2 tvaII 0.0092
2541 Neopullulanase 1 tvaI 0.0092
3747 Cellulase B precursor celB 0.0092
4811 Amylosucrase ams 0.0092
2324 Botulinum neurotoxin type B botB 0.0092
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0092
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0089
1881 Hexokinase-1 HK1 0.0087
2826 Glucose--fructose oxidoreductase gfo 0.0087
3225 Shiga toxin B-chain stxB 0.0087
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0083
2508 Cyclomaltodextrin glucanotransferase cgt 0.0083
2523 Cyclomaltodextrin glucanotransferase cgt 0.0083
3207 Cyclomaltodextrin glucanotransferase amyA 0.0083
6614 Lactase-like protein LCTL 0.0083
1675 Glucokinase GCK 0.0083
4662 Glucokinase glk 0.0083
1024 Solute carrier family 22 member 11 SLC22A11 0.008
4692 A/G-specific adenine glycosylase mutY 0.008
3668 Maltose-binding periplasmic protein precursor malE 0.008
2802 Endoglucanase G celCCG 0.008
2570 Tetanus toxin tetX 0.008
4272 POSSIBLE CELLULASE CELA1 celA1 0.0079
6143 Solute carrier family 22 member 7 SLC22A7 0.0079
2440 Endoglucanase F celCCF 0.0075
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0072
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0072
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0072
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0072
6142 Solute carrier family 22 member 8 SLC22A8 0.007
2252 Endoglucanase 5A cel5A 0.007
2245 Xylose isomerase xylA 0.0069
2253 Xylose isomerase xylA 0.0069
2260 Xylose isomerase xylA 0.0069
2431 Xylose isomerase xylA 0.0069
10 Glycogen phosphorylase, liver form PYGL 0.0065
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0064
3947 Xanthine dehydrogenase/oxidase XDH 0.0064
2427 Ferrichrome-iron receptor fhuA 0.0064
1729 Solute carrier family 22 member 6 SLC22A6 0.0064
4936 Cytochrome c2 iso-2 Not Available 0.0063
4905 Cytochrome c2 Not Available 0.0062
4939 Cytochrome c2 cycA 0.0062
4979 Cytochrome c2 cycA 0.0062
6673 Cytochrome c2 cycA 0.0062
4934 Cytochrome c-551 nirM 0.0062
5218 Cytochrome c-551 nirM 0.0062
4916 Cyanoglobin glbN 0.0062
5000 HemO hemO 0.0062
4925 Cytochrome c-type protein SHP shp 0.0062
4975 Cytochrome c-556 RPA3973 0.0062
4942 Diheme cytochrome c napB napB 0.0062
4984 Neuroglobin NGB 0.0062
4904 Cytochrome c family protein GSU1996 0.0062
4943 Cytochrome c6 petJ 0.0062
4954 Soluble cytochrome b558 Not Available 0.0062
4961 Hemophore HasA hasA 0.0062
4907 Cytochrome c-L moxG 0.0062
6865 Cytochrome c-L moxG 0.0062
4994 Hemoglobin-like protein HbO glbO 0.0062
4915 Cytochrome c-550 psbV 0.0062
4959 Cytochrome c-550 psbV 0.0062
5216 Cytochrome c-550 psbV 0.0062
4998 Hemoglobin-like protein yjbI yjbI 0.0062
4947 Bacterial hemoglobin vhb 0.0062
3116 Bacterioferritin bfr 0.0062
4906 Bacterioferritin bfr 0.0062
4965 Bacterioferritin bfr 0.0062
4960 Putative cytochrome P450-family protein SCO7417 0.0062
4937 Cytochrome oxidase subunit II rcoxA 0.0062
4971 Nonaheme cytochrome c hmcA 0.0062
4989 Cytochrome c551 peroxidase ccp 0.0062
5222 Cytochrome c551 peroxidase ccpA 0.0062
4910 Cytoglobin CYGB 0.0062
4976 Apocytochrome f petA 0.0062
6407 Apocytochrome f petA 0.0062
4981 Iron-starvation protein PigA pigA 0.0062
4909 CooA protein cooA 0.0062
4972 P450cin cinA 0.0062
4764 Cytochrome P450 165C4 CYP165C4 0.0062
4935 Cytochrome c-554 cycA1 0.0062
4926 Heme-based aerotactic transducer hemAT hemAT 0.0062
644 Heme oxygenase 2 HMOX2 0.0062
4982 Heme oxygenase 2 pbsA2 0.0062
4922 Cytochrome c, putative SO_4144 0.0062
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0062
4903 Methyl-accepting chemotaxis protein Tar4 0.0062
4999 Cytochrome P450 165B3 CYP165B3 0.0062
4931 Cytochrome P450 167A1 CYP167A1 0.0062
3093 Catalase HPII katE 0.0062
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0062
4952 Catalase/peroxidase katA 0.0062
4993 Hydroxylamine oxidoreductase hao1 0.0061
193 Beta-1 adrenergic receptor ADRB1 0.0057
766 Beta-2 adrenergic receptor ADRB2 0.0056
76 Nitric-oxide synthase, brain NOS1 0.0054
4385 Cytochrome c' Not Available 0.0054
4967 Cytochrome c' cycA 0.0054
5223 Cytochrome c' cycP 0.0054
4990 PpcA ppcA 0.0054
4813 Heme oxygenase hmuO 0.0054
5769 Heme oxygenase Not Available 0.0054
3375 Acidic cytochrome c3 Not Available 0.0054
4037 Hypothetical protein GPX1 0.0054
4297 Hypothetical protein SP_1951 0.0054
4521 Hypothetical protein BC_2969 0.0054
4540 Hypothetical protein TM_1070 0.0054
4555 Hypothetical protein MT1739 0.0054
4569 Hypothetical protein mshD 0.0054
4578 Hypothetical protein PA3270 0.0054
4747 Hypothetical protein PA3967 0.0054
5177 Hypothetical protein TM_0096 0.0054
5194 Hypothetical protein PA1204 0.0054
5240 Hypothetical protein Rv2991 0.0054
5370 Hypothetical protein TM_1158 0.0054
5710 Hypothetical protein Tb927.5.1360 0.0054
2119 Cytochrome b5 CYB5A 0.0054
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0054
4988 Sulfite oxidase, mitochondrial SUOX 0.0054
2915 Sensor protein fixL fixL 0.0054
4944 Sensor protein fixL fixL 0.0054
4289 Cytochrome P450 TT_P0059 0.0054
6262 Cytochrome P450 staP 0.0054
3570 Cytochrome P450 152A1 cypC 0.0054
4920 Peroxidase/catalase katG 0.0054
1152 Glycogen phosphorylase, muscle form PYGM 0.0052
556 Alpha-1A adrenergic receptor ADRA1A 0.005
3670 Soluble cytochrome b562 precursor cybC 0.005
3291 Cytochrome c-552 cycA 0.005
4927 Cytochrome c-552 nrfA 0.005
4938 Cytochrome c-552 cycA 0.005
4953 Cytochrome c-552 nrfA 0.005
5217 Cytochrome c-552 cycM 0.005
3411 Cytochrome P450 121 cyp121 0.0049
3102 Flavohemoprotein hmp 0.0049
4969 Flavohemoprotein hmp 0.0049
2617 Nitric oxide synthase oxygenase nos 0.0049
2701 Nitric oxide synthase oxygenase nos 0.0049
6024 Cytochrome P450 1A1 CYP1A1 0.0048
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0047
2230 Catalase CAT 0.0046
3249 Catalase katA 0.0046
3625 Catalase katA 0.0046
4539 Catalase katA 0.0046
4941 Catalase katB 0.0046
6013 Cytochrome P450 2E1 CYP2E1 0.0045
4878 Glycoprotein hormones alpha chain CGA 0.0045
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0045
1072 Granzyme B GZMB 0.0045
4877 Beta-mannanase man 0.0044
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0044
757 Fusion glycoprotein F0 F 0.0044
4875 Fusion glycoprotein F0 F 0.0044
4880 Membrane cofactor protein CD46 0.0044
4856 CD209 antigen CD209 0.0044
4889 Ig epsilon chain C region IGHE 0.0044
4869 Major capsid protein A430L 0.0044
4852 Reticulon-4 receptor RTN4R 0.0044
4850 Beta-2-glycoprotein 1 APOH 0.0044
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0044
1354 Beta-glucuronidase GUSB 0.0044
442 Envelope glycoprotein gp41 0.0044
4859 Envelope glycoprotein env 0.0044
4189 Alpha-galactosidase A GLA 0.0044
3352 Structural polyprotein Not Available 0.0044
3628 Structural polyprotein Not Available 0.0044
4892 Structural polyprotein Not Available 0.0044
4845 ADAM 33 ADAM33 0.0044
4721 Beta-1,4-mannanase manA 0.0044
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0044
2972 6-deoxyerythronolide B hydroxylase eryF 0.0044
605 Fumarate reductase flavoprotein subunit frdA 0.0044
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0044
3673 Fumarate reductase flavoprotein subunit fccA 0.0044
4912 Fumarate reductase flavoprotein subunit ifcA 0.0044
6549 Fumarate reductase flavoprotein subunit frdA 0.0044
260 Cytochrome P450 51 ERG11 0.0042
761 Cytochrome P450 51 ERG11 0.0042
3163 Cytochrome P450 51 cyp51 0.0042
518 Peroxidase/catalase T katG 0.0041
4200 Cytochrome P450 1A2 CYP1A2 0.004
693 Hemoglobin subunit beta HBB 0.0039
6268 Hydroxyacid oxidase 1 HAO1 0.0039
6858 Inactive carboxylesterase 4 CES1P1 0.0039
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0039
1379 Interleukin-12 subunit beta IL12B 0.0039
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0039
793 T-cell surface antigen CD2 CD2 0.0039
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0039
4890 Hemagglutinin HA 0.0039
6566 Hemagglutinin Not Available 0.0039
4861 Interleukin-6 receptor alpha chain IL6R 0.0039
3837 Cytokine receptor common beta chain CSF2RB 0.0039
1588 Multidrug resistance protein 1 ABCB1 0.0038
4119 Cytochrome P450 2D6 CYP2D6 0.0038
810 Heme oxygenase 1 HMOX1 0.0037
3391 Heme oxygenase 1 pbsA1 0.0037
358 Cystathionine beta-synthase CBS 0.0036
3444 Cyanovirin-N Not Available 0.0036
1859 Prostatic acid phosphatase ACPP 0.0036
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.0036
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0036
3140 Hemagglutinin-neuraminidase HN 0.0036
3609 Hemagglutinin-neuraminidase HN 0.0036
2297 Genome polyprotein Not Available 0.0036
2322 Genome polyprotein Not Available 0.0036
2694 Genome polyprotein Not Available 0.0036
2719 Genome polyprotein Not Available 0.0036
2860 Genome polyprotein Not Available 0.0036
2928 Genome polyprotein Not Available 0.0036
3160 Genome polyprotein Not Available 0.0036
3260 Genome polyprotein Not Available 0.0036
4783 Genome polyprotein Not Available 0.0036
5726 Genome polyprotein Not Available 0.0036
5779 Genome polyprotein Not Available 0.0036
5867 Genome polyprotein Not Available 0.0036
6253 Genome polyprotein Not Available 0.0036
6301 Genome polyprotein Not Available 0.0036
6380 Genome polyprotein Not Available 0.0036
6381 Genome polyprotein Not Available 0.0036
6437 Genome polyprotein Not Available 0.0036
6520 Genome polyprotein Not Available 0.0036
6521 Genome polyprotein Not Available 0.0036
6652 Genome polyprotein Not Available 0.0036
6734 Genome polyprotein Not Available 0.0036
6735 Genome polyprotein Not Available 0.0036
6736 Genome polyprotein Not Available 0.0036
6737 Genome polyprotein Not Available 0.0036
6738 Genome polyprotein Not Available 0.0036
6739 Genome polyprotein Not Available 0.0036
6744 Genome polyprotein Not Available 0.0036
6748 Genome polyprotein Not Available 0.0036
6894 Genome polyprotein Not Available 0.0036
6898 Genome polyprotein Not Available 0.0036
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0036
2298 Cytochrome P450-cam camC 0.0034
4787 Envelope glycoprotein gp160 env 0.0034
4820 Envelope glycoprotein gp160 env 0.0034
5727 Envelope glycoprotein gp160 env 0.0034
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0032
852 Heparin cofactor 2 SERPIND1 0.0032
554 Low-density lipoprotein receptor LDLR 0.0032
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0032
64 Neuraminidase NA 0.0031
641 Neuraminidase NA 0.0031
2676 Neuraminidase NA 0.0031
3026 Neuraminidase NA 0.0031
3519 Neuraminidase NA 0.0031
6007 Neuraminidase NA 0.0031
1439 Lactotransferrin LTF 0.003
595 Fibrinogen alpha chain FGA 0.0029
1243 Cathepsin D CTSD 0.0029
958 Insulin-like growth factor 1 receptor IGF1R 0.0029
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0029
7 Nitric oxide synthase, inducible NOS2 0.0029
291 Nitric-oxide synthase, endothelial NOS3 0.0028
6307 Ig gamma-2 chain C region IGHG2 0.0028
6500 Phospholipase A2 PLA2G1B 0.0027
2207 Rhodopsin RHO 0.0025
6106 Cytochrome P450 2C18 CYP2C18 0.0024
4785 Ig gamma-1 chain C region IGHG1 0.0023
290 Prostaglandin G/H synthase 2 PTGS2 0.0021
952 Dipeptidyl peptidase 4 DPP4 0.002
4604 Liver carboxylesterase 1 CES1 0.002
6030 Cytochrome P450 2B6 CYP2B6 0.0019
4924 Cytochrome P450 2C8 CYP2C8 0.0017
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