DT-Web

DB02552 - Geranyl Diphosphate


Identification
Name Geranyl Diphosphate
Accession Number DB02552 (EXPT01640)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 314.2091
Groups experimental
Monoisotopic Weight 314.068426018
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Name 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Gene Name ispF
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.4903
IspD/ispF bifunctional enzyme [Includes: 2-C-methyl-D-erythritol 4- phosphate cytidylyltransferase
Name IspD/ispF bifunctional enzyme [Includes: 2-C-methyl-D-erythritol 4- phosphate cytidylyltransferase
Gene Name ispDF
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.8043
2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Name 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase
Gene Name ispF
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.4903
Farnesyl pyrophosphate synthetase
Name Farnesyl pyrophosphate synthetase
Gene Name FDPS
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.1205
Prenyltransferase
Name Prenyltransferase
Gene Name Not Available
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.8088
Geranylgeranyl pyrophosphate synthetase
Name Geranylgeranyl pyrophosphate synthetase
Gene Name GGPS1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.6248
Short-chain Z-isoprenyl diphosphate synthetase
Name Short-chain Z-isoprenyl diphosphate synthetase
Gene Name Rv1086
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.7761
Undecaprenyl pyrophosphate synthase
Name Undecaprenyl pyrophosphate synthase
Gene Name uppS
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available

Predictions


Id Partner name Gene Name Score
2937 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 1.4903
4620 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 1.4903
6594 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 1.4903
6646 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase ispF 1.4903
5744 Undecaprenyl pyrophosphate synthetase uppS 0.2626
4608 Putative cytochrome P450 SCO1207 0.2036
4963 Putative cytochrome P450 SCO2884 0.2036
6254 Putative cytochrome P450 SCO6998 0.2036
2909 Cytidylate kinase cmk 0.168
2765 3-deoxy-manno-octulosonate cytidylyltransferase kpsU 0.1607
3120 3-deoxy-manno-octulosonate cytidylyltransferase kdsB 0.1607
3779 Alpha-2,3/8-sialyltransferase cst-II 0.1539
6576 Geranylgeranyl transferase type-2 subunit beta RABGGTB 0.1439
6575 Geranylgeranyl transferase type-2 subunit alpha RABGGTA 0.1439
6548 4-hydroxy-3-methylbut-2-enyl diphosphate reductase ispH 0.1364
3692 Coenzyme A biosynthesis bifunctional protein coaBC coaBC 0.1339
6595 Lantibiotic nisin-Z nisZ 0.1286
4128 Protein farnesyltransferase subunit beta FNTB 0.12
2867 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ispE 0.1179
4129 Protein farnesyltransferase/geranylgeranyltransferase type I alpha subunit FNTA 0.1177
3019 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase ispD 0.1089
3344 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase ispD 0.1089
2697 Uridine-cytidine kinase 2 UCK2 0.1076
6574 GTPase KRas KRAS 0.1031
702 UMP-CMP kinase CMPK1 0.096
6547 Isopentenyl-diphosphate Delta-isomerase 1 IDI1 0.0696
2944 N-acylneuraminate cytidylyltransferase neuA 0.0678
7074 N-acylneuraminate cytidylyltransferase CMAS 0.0678
2967 CDP-paratose 2-epimerase rfbE 0.059
6597 Mevalonate kinase MVK 0.0565
6647 Geranyltranstransferase (Farnesyldiphosphate synthase) ispA 0.0522
1994 Geranylgeranyl transferase type-1 subunit beta PGGT1B 0.0496
862 Multidrug resistance-associated protein 1 ABCC1 0.0474
6368 Dehydrosqualene synthase crtM 0.0454
2756 Geranyltranstransferase ispA 0.042
6056 Receptor-type tyrosine-protein phosphatase epsilon PTPRE 0.0369
1376 Tyrosine-protein phosphatase non-receptor type 4 PTPN4 0.0369
290 Prostaglandin G/H synthase 2 PTGS2 0.0349
4284 Pentaerythritol tetranitrate reductase onr 0.0348
6055 Receptor-type tyrosine-protein phosphatase S PTPRS 0.0322
6057 V-type proton ATPase catalytic subunit A ATP6V1A 0.0301
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