DT-Web

DB08604 - TRICLOSAN


Identification
Name TRICLOSAN
Accession Number DB08604
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 289.542
Groups experimental
Monoisotopic Weight 287.951162589
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Enoyl-[acyl-carrier-protein] reductase [NADH]
Name Enoyl-[acyl-carrier-protein] reductase [NADH]
Gene Name fabI
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.9018
2,4-dienoyl-CoA reductase, mitochondrial
Name 2,4-dienoyl-CoA reductase, mitochondrial
Gene Name DECR1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.0332
Enoyl-[acyl-carrier-protein] reductase [NADH]
Name Enoyl-[acyl-carrier-protein] reductase [NADH]
Gene Name inhA
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.9018
Enoyl-[acyl-carrier-protein] reductase [NADH]
Name Enoyl-[acyl-carrier-protein] reductase [NADH]
Gene Name fabI
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.9018
Enoyl-(Acyl-carrier-protein) reductase
Name Enoyl-(Acyl-carrier-protein) reductase
Gene Name fabI
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.9194
Enoyl-[acyl-carrier-protein] reductase [NADH]
Name Enoyl-[acyl-carrier-protein] reductase [NADH]
Gene Name fabI
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.9018

Predictions


Id Partner name Gene Name Score
6877 Enoyl-(Acyl-carrier-protein) reductase fabK 0.9194
518 Peroxidase/catalase T katG 0.0785
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0191
646 Malate dehydrogenase, cytoplasmic MDH1 0.0161
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0142
4509 Acetoin(diacetyl) reductase budC 0.0135
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0128
444 Alcohol dehydrogenase 1B ADH1B 0.0127
4435 L-aspartate dehydrogenase nadX 0.0123
4495 3-oxoacyl-(Acyl carrier protein) reductase TM_1169 0.0123
4428 Redox-sensing transcriptional repressor rex rex 0.0123
4423 Levodione reductase lvr 0.0123
4472 Glucose 1-dehydrogenase Not Available 0.0123
4447 Hypothetical protein yhfP yhfP 0.0123
4449 ADP-ribosyltransferase Not Available 0.0123
4448 L-2-hydroxyisocaproate dehydrogenase Not Available 0.0123
2350 3-isopropylmalate dehydrogenase leuB 0.0123
3092 3-isopropylmalate dehydrogenase leuB 0.0123
4455 Glycerol dehydrogenase gldA 0.0123
4456 Inorganic polyphosphate/ATP-NAD kinase ppnK 0.0123
4507 Alanine dehydrogenase ald 0.0123
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.0123
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.0123
4505 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase bphB 0.0123
4418 AGR_L_3209p AGR_L_3209 0.0123
4443 Quinate/shikimate dehydrogenase ydiB 0.0123
4497 Benzyl alcohol dehydrogenase xylB 0.0123
4500 L-lactate dehydrogenase 2 ldh2 0.0123
4446 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase Not Available 0.0123
4471 CDP-D-glucose-4,6-dehydratase ascB 0.0123
3735 NAD(P) transhydrogenase subunit alpha part 1 pntAA 0.0123
4475 Hypothetical protein Rv0046c/MT0052 ino1 0.0123
3381 Alcohol dehydrogenase Not Available 0.0123
4508 Alcohol dehydrogenase adhA 0.0123
4467 Alpha-glucosidase, putative TM_0752 0.0123
3729 Citrate synthase gltA 0.0123
4575 Citrate synthase cit 0.0123
4580 Citrate synthase gltA 0.0123
4414 Dehydrogenase TT_P0035 0.0123
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0123
3726 D-3-phosphoglycerate dehydrogenase serA 0.0123
4291 D-3-phosphoglycerate dehydrogenase serA 0.0123
4451 Vip2Ac vip2Ac 0.0123
4466 Glutathione-independent formaldehyde dehydrogenase fdhA 0.0123
4502 Formate dehydrogenase Not Available 0.0123
4487 Transcriptional regulator nadR nadR 0.0123
4506 Myo-inositol-1-phosphate synthase-related protein TM_1419 0.0123
2826 Glucose--fructose oxidoreductase gfo 0.0117
1199 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 ART1 0.0107
3615 Dihydrodipicolinate reductase dapB 0.0107
3618 Dihydrodipicolinate reductase dapB 0.0107
4462 Dihydrodipicolinate reductase dapB 0.0107
6698 Dehydrogenase/reductase SDR family member 4-like 2 DHRS4L2 0.0107
4503 NADPH-flavin oxidoreductase frp 0.0107
4486 Phenol 2-hydroxylase component B pheA2 0.0107
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0107
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.0107
3059 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase fabG3 0.0107
2967 CDP-paratose 2-epimerase rfbE 0.0107
2424 L-lactate dehydrogenase ldh 0.0107
2641 L-lactate dehydrogenase Not Available 0.0107
4437 L-lactate dehydrogenase ldh 0.0107
4442 L-lactate dehydrogenase ldh 0.0107
4427 TDP-glucose-4,6-dehydratase desIV 0.0107
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0107
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0107
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.0107
4482 UDP-galactose 4-epimerase galE 0.0107
126 D-lactate dehydrogenase dld 0.0107
3545 D-lactate dehydrogenase Not Available 0.0107
4510 D-lactate dehydrogenase ldhA 0.0107
2336 2,3-diketo-L-gulonate reductase dlgD 0.0107
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.0107
3177 dTDP-glucose 4,6-dehydratase rfbB 0.0107
4499 dTDP-glucose 4,6-dehydratase rmlB 0.0107
4450 Iota toxin component Ia Not Available 0.0107
4439 Ferredoxin reductase bphA4 0.0107
2591 Urocanate hydratase hutU 0.0107
4477 Dihydrolipoyl dehydrogenase lpdV 0.0107
5077 Dihydrolipoyl dehydrogenase Not Available 0.0107
5117 Dihydrolipoyl dehydrogenase lpd 0.0107
2018 Deoxyhypusine synthase DHPS 0.0107
3081 3-dehydroquinate synthase aroB 0.0107
2507 Diphtheria toxin Not Available 0.0107
2393 Maltose-6'-phosphate glucosidase glvA 0.0107
4498 Ornithine cyclodeaminase PP3533 0.0107
2881 Gamma-aminobutyraldehyde dehydrogenase prr 0.0107
4496 C-terminal-binding protein 1 CTBP1 0.0107
2538 6-phospho-beta-glucosidase bglT bglT 0.0107
2683 Mono-ADP-ribosyltransferase C3 C3 0.0098
3296 Nicotinamide mononucleotide adenylyltransferase 1 NMNAT1 0.0098
4504 WbpP Not Available 0.0098
2799 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Not Available 0.0098
711 UDP-glucose 6-dehydrogenase UGDH 0.0098
3672 UDP-glucose 6-dehydrogenase hasB 0.0098
4440 NADH peroxidase npr 0.0098
3367 GDP-mannose 6-dehydrogenase algD 0.0098
4318 Siroheme synthase cysG 0.0098
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0098
4343 Alpha-glucosidase aglA 0.0098
5326 Oxidoreductase, short chain dehydrogenase/reductase family TM_0441 0.0097
3772 3-oxoacyl-[acyl-carrier-protein] reductase fabG 0.0097
5157 Dehydrogenase/reductase SDR family member 11 DHRS11 0.0097
3778 NAD(P) transhydrogenase subunit beta pntB 0.0097
5322 Oxidoreductase ydhF ydhF 0.0097
4403 Protein iolS iolS 0.0097
5330 General stress protein 69 yhdN 0.0097
5346 Oxidoreductase, aldo/keto reductase family TM_1009 0.0097
5342 NADH-dependent butanol dehydrogenase, putative TM_0820 0.0097
5332 MtdA bifunctional protein mtdA 0.0097
5333 Alcohol dehydrogenase, iron-containing TM_0920 0.0097
5343 NADP-dependent fatty aldehyde dehydrogenase aldH 0.0097
6102 Arylamine N-acetyltransferase 2 NAT2 0.0096
2617 Nitric oxide synthase oxygenase nos 0.0093
2701 Nitric oxide synthase oxygenase nos 0.0093
3333 Nicotinamide mononucleotide adenylyltransferase 3 NMNAT3 0.0093
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0093
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0093
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0093
3191 Histidinol dehydrogenase hisD 0.0093
3070 Adenosylhomocysteinase AHCY 0.0093
4424 Adenosylhomocysteinase PFE1050w 0.0093
6278 Adenosylhomocysteinase ahcY 0.0093
63 Malate dehydrogenase mdh 0.0092
2329 Malate dehydrogenase mdh 0.0092
3445 Malate dehydrogenase mdh 0.0092
4420 Malate dehydrogenase mdh 0.0092
4438 Malate dehydrogenase mdh 0.0092
816 Biliverdin reductase A BLVRA 0.0092
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0092
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0092
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0092
4476 Mannitol dehydrogenase mtlD 0.0091
327 Glutathione reductase gor 0.0089
5110 Glutathione reductase GR2 0.0089
597 Dihydropteridine reductase QDPR 0.0089
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0089
328 Sorbitol dehydrogenase SORD 0.0089
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0089
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0089
396 Alcohol dehydrogenase 4 ADH4 0.0089
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0089
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0089
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0089
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0086
77 L-lactate dehydrogenase B chain LDHB 0.0086
12 Alcohol dehydrogenase class 3 ADH5 0.0086
4491 DNA ligase, NAD-dependent ligA 0.0085
989 L-xylulose reductase DCXR 0.0084
2636 Shikimate dehydrogenase aroE 0.0084
3515 Shikimate dehydrogenase aroE 0.0084
5328 Prostaglandin F synthase Tb11.02.2310 0.0084
4582 Putative pteridine reductase 2 ptr2 0.0084
2375 ADP-L-glycero-D-manno-heptose-6-epimerase hldD 0.0084
5073 Ferredoxin--NADP reductase petH 0.0084
5076 Ferredoxin--NADP reductase fpr 0.0084
5119 Ferredoxin--NADP reductase petH 0.0084
5121 Ferredoxin--NADP reductase fpr 0.0084
3446 NADP-dependent alcohol dehydrogenase adh 0.0084
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0084
2305 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 0.0084
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0084
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0084
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0084
729 GDP-L-fucose synthetase TSTA3 0.0084
3463 GDP-L-fucose synthetase fcl 0.0084
2286 Isocitrate dehydrogenase [NADP] icd 0.0084
2302 Isocitrate dehydrogenase [NADP] icd 0.0084
2771 Isocitrate dehydrogenase [NADP] icd 0.0084
473 L-lactate dehydrogenase A chain LDHA 0.0084
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0084
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0084
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0084
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0084
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0084
2762 UDP-glucose 4-epimerase GALE 0.0083
3461 UDP-glucose 4-epimerase galE 0.0083
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0081
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0079
4531 Putative ketoacyl reductase actIII 0.0078
6297 Prostaglandin reductase 1 PTGR1 0.0078
3062 Aspartate-semialdehyde dehydrogenase asd 0.0078
6862 Aldo-keto reductase family 1 member B10 AKR1B10 0.0078
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0074
666 NADP-dependent malic enzyme ME1 0.0074
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0074
1124 Sepiapterin reductase SPR 0.0073
2675 Pteridine reductase 1 PTR1 0.0073
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0073
251 Alcohol dehydrogenase 1A ADH1A 0.0073
611 Retinal dehydrogenase 1 ALDH1A1 0.0073
2159 Quinone oxidoreductase CRYZ 0.0073
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0072
569 Retinal dehydrogenase 2 ALDH1A2 0.0072
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0071
714 Glutathione reductase, mitochondrial GSR 0.0067
517 Alcohol dehydrogenase 1C ADH1C 0.0064
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0064
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0063
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0063
654 Flavin reductase BLVRB 0.0061
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0059
5718 Cytochrome P450 2A6 CYP2A6 0.0056
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0055
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0053
6013 Cytochrome P450 2E1 CYP2E1 0.005
76 Nitric-oxide synthase, brain NOS1 0.0049
822 Aldose reductase AKR1B1 0.0049
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0048
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0048
4120 NADPH--cytochrome P450 reductase POR 0.0048
4924 Cytochrome P450 2C8 CYP2C8 0.0047
365 Dihydrofolate reductase DHFR 0.0046
2381 Dihydrofolate reductase DFR1 0.0046
2833 Dihydrofolate reductase Not Available 0.0046
2931 Dihydrofolate reductase folA 0.0046
3544 Dihydrofolate reductase folA 0.0046
3682 Dihydrofolate reductase folA 0.0046
6642 Dihydrofolate reductase folA 0.0046
6756 Dihydrofolate reductase dfrA 0.0046
6016 Cytochrome P450 2C19 CYP2C19 0.0045
4200 Cytochrome P450 1A2 CYP1A2 0.0044
4757 Cytochrome P450 2C9 CYP2C9 0.0043
4119 Cytochrome P450 2D6 CYP2D6 0.0042
4512 Cytochrome P450 3A4 CYP3A4 0.0038
3689 Endoglucanase A celA 0.0033
5411 Slt-IIvB stxB2e 0.0033
5563 Galectin-2 LGALS2 0.0033
5565 Inorganic polyphosphate/ATP-glucomannokinase ppgmk 0.0033
5046 Ecotin eco 0.0033
5554 D-galactose-binding periplasmic protein mglB 0.0033
3741 D-galactose-binding periplasmic protein precursor mglB 0.0033
4668 Laminarinase TM_0024 0.0033
1875 Pulmonary surfactant-associated protein D SFTPD 0.0033
3009 Beta-glucanase Not Available 0.0033
5562 Hexokinase Not Available 0.0033
3793 Aspartate ammonia-lyase aspA 0.0033
4670 Cellulase B celB 0.0033
5569 Endo-1,4-beta glucanase EngF engF 0.0033
5553 Endoglucanase E1 Acel_0614 0.0033
5568 Endoglucanase C307 celC307 0.0033
5570 Endoglucanase E-4 celD 0.0033
4667 BH0236 protein BH0236 0.0033
5559 Neopullulanase nplT 0.0033
4671 Endoglucanase C cenC 0.0033
3744 Endoglucanase SS precursor celS 0.0033
3525 ADP-ribose pyrophosphatase, mitochondrial NUDT9 0.0028
1503 Galectin-7 LGALS7 0.0028
1184 Interferon beta IFNB1 0.0028
5416 Coat protein VP1 Not Available 0.0028
5176 YtnJ moxC 0.0028
5498 Maltoporin lamB 0.0028
5561 Maltoporin lamB 0.0028
4622 Amylase Not Available 0.0028
5247 Endo-1,4-beta-xylanase Not Available 0.0028
5248 Endo-1,4-beta-xylanase xlnA 0.0028
5250 Endo-1,4-beta-xylanase xyl 0.0028
5056 Maltooligosyltrehalose trehalohydrolase, putative treZ 0.0028
4669 Endo-1,4-beta-xylanase A xynA 0.0028
4715 Endo-1,4-beta-xylanase A xlnA 0.0028
5560 Endo-1,4-beta-xylanase A xynA 0.0028
2705 Dimethyl sulfoxide reductase dmsA 0.0028
2728 Glucan 1,4-alpha-maltotetraohydrolase amyP 0.0028
3547 Enterotoxin type B entB 0.0026
2856 Glucosamine-6-phosphate isomerase GNPDA1 0.0026
3747 Cellulase B precursor celB 0.0026
3153 Quinoprotein glucose dehydrogenase-B gdhB 0.0026
2564 Glucan 1,4-alpha-maltohexaosidase Not Available 0.0026
4811 Amylosucrase ams 0.0026
2531 Alpha-amylase amyE 0.0026
2948 Alpha-amylase amy 0.0026
3169 Alpha-amylase Not Available 0.0026
2541 Neopullulanase 1 tvaI 0.0026
4819 Hydrolase Not Available 0.0026
5249 Hydrolase Not Available 0.0026
5436 Hydrolase Not Available 0.0026
3091 Maltodextrin phosphorylase malP 0.0026
2606 Neopullulanase 2 tvaII 0.0026
2324 Botulinum neurotoxin type B botB 0.0026
3225 Shiga toxin B-chain stxB 0.0025
4666 Fucose-binding lectin PA-IIL lecB 0.0025
4830 Aldose 1-epimerase galM 0.0025
3365 Beta-amylase spoII 0.0025
1881 Hexokinase-1 HK1 0.0025
2372 Bifunctional tail protein 9 0.0025
3030 Salivary alpha-amylase AMY1A 0.0024
6614 Lactase-like protein LCTL 0.0024
2293 Cyclomaltodextrin glucanotransferase Not Available 0.0024
2508 Cyclomaltodextrin glucanotransferase cgt 0.0024
2523 Cyclomaltodextrin glucanotransferase cgt 0.0024
3207 Cyclomaltodextrin glucanotransferase amyA 0.0024
1675 Glucokinase GCK 0.0024
4662 Glucokinase glk 0.0024
4692 A/G-specific adenine glycosylase mutY 0.0023
3668 Maltose-binding periplasmic protein precursor malE 0.0023
2802 Endoglucanase G celCCG 0.0023
2448 Exoglucanase/xylanase [Includes: Exoglucanase cex 0.0023
2570 Tetanus toxin tetX 0.0023
4272 POSSIBLE CELLULASE CELA1 celA1 0.0022
2440 Endoglucanase F celCCF 0.0021
2430 Chondroitinase B cslB 0.0021
2245 Xylose isomerase xylA 0.002
2253 Xylose isomerase xylA 0.002
2260 Xylose isomerase xylA 0.002
2431 Xylose isomerase xylA 0.002
2252 Endoglucanase 5A cel5A 0.0019
2723 Cholera enterotoxin subunit B ctxB 0.0019
10 Glycogen phosphorylase, liver form PYGL 0.0018
2427 Ferrichrome-iron receptor fhuA 0.0018
4513 Pancreatic alpha-amylase AMY2A 0.0018
1152 Glycogen phosphorylase, muscle form PYGM 0.0015
20 Prostaglandin G/H synthase 1 PTGS1 0.001
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