DT-Web

DB04355 - Uridine-5'-Monophosphate Glucopyranosyl-Monophosphateester


Identification
Name Uridine-5'-Monophosphate Glucopyranosyl-Monophosphateester
Accession Number DB04355 (EXPT03198)
Type small molecule
Description A key intermediate in carbohydrate metabolism. Serves as a precursor of glycogen, can be metabolized into UDPgalactose and UDPglucuronic acid which can then be incorporated into polysaccharides as galactose and glucuronic acid. Also serves as a precursor of sucrose lipopolysaccharides, and glycosphingolipids. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 566.3018
Groups experimental
Monoisotopic Weight 566.055020376
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


WbpP
Name WbpP
Gene Name Not Available
Pharmacological action unknown
Actions Not Available
References Not Available
DTHybrid score 0.7122
Glycogenin-1
Name Glycogenin-1
Gene Name GYG1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available
UDP-glucose 4-epimerase
Name UDP-glucose 4-epimerase
Gene Name GALE
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.2005
Alpha,alpha-trehalose-phosphate synthase [UDP-forming]
Name Alpha,alpha-trehalose-phosphate synthase [UDP-forming]
Gene Name otsA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.1921
Glucose-1-phosphate thymidylyltransferase
Name Glucose-1-phosphate thymidylyltransferase
Gene Name rmlA
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7081
UDP-glucose 4-epimerase
Name UDP-glucose 4-epimerase
Gene Name galE
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.2005
DNA beta-glucosyltransferase
Name DNA beta-glucosyltransferase
Gene Name bgt
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7471
Glycosyltransferase 6 domain-containing protein 1
Name Glycosyltransferase 6 domain-containing protein 1
Gene Name GLT6D1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score Not Available

Predictions


Id Partner name Gene Name Score
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.7081
2608 UDP-N-acetylglucosamine 2-epimerase wecB 0.2925
237 Histo-blood group ABO system transferase ABO 0.2728
2590 Galactose-1-phosphate uridylyltransferase galT 0.2712
2612 UDP-N-acetylhexosamine pyrophosphorylase UAP1 0.259
2651 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase murG 0.1777
3523 Spore coat polysaccharide biosynthesis protein spsA spsA 0.1583
4482 UDP-galactose 4-epimerase galE 0.1466
2291 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 B3GAT1 0.1378
3408 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 B3GAT3 0.1378
520 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.1197
2306 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.1197
2367 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.1197
5252 Bifunctional protein glmU glmU 0.1197
6789 Bifunctional protein glmU glmU 0.1197
3481 Glucose-1-phosphate thymidylyltransferase 2 rmlA2 0.1127
2555 Pol polyprotein pol 0.1105
3242 Pol polyprotein gag-pol 0.1105
3471 Pol polyprotein gag-pro-pol 0.1105
5256 Pol polyprotein pol 0.1105
6469 Pol polyprotein gag-pol 0.1105
6565 Pol polyprotein Not Available 0.1105
509 Thymidine kinase TK 0.1088
570 Thymidine kinase TK 0.1088
2559 Thymidine kinase TK 0.1088
3430 Thymidine kinase tdk 0.1088
3518 Thymidine kinase TK 0.1088
5301 Thymidine kinase tdk 0.1088
5771 Thymidine kinase ORF36 0.1088
7009 Thymidine kinase ORF36 0.1088
702 UMP-CMP kinase CMPK1 0.0997
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.0961
3299 DNA primase/helicase 4 0.0946
3244 Ribonucleoside-diphosphate reductase 2 alpha subunit nrdE 0.0872
2633 Anaerobic ribonucleoside-triphosphate reductase NRDD 0.0824
287 Beta-1,4-galactosyltransferase 1 B4GALT1 0.0796
2320 Thymidine kinase, cytosolic TK1 0.073
2251 Thymidylate kinase tmk 0.0721
2254 Thymidylate kinase DTYMK 0.0721
3522 Thymidylate kinase tmk 0.0721
2538 6-phospho-beta-glucosidase bglT bglT 0.0631
2393 Maltose-6'-phosphate glucosidase glvA 0.0631
1881 Hexokinase-1 HK1 0.0473
2503 Phosphomannomutase/phosphoglucomutase algC 0.0452
2597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] glmS 0.0436
2206 Glucose-6-phosphate isomerase GPI 0.0412
822 Aldose reductase AKR1B1 0.0311
1152 Glycogen phosphorylase, muscle form PYGM 0.0283
4435 L-aspartate dehydrogenase nadX 0.01
4428 Redox-sensing transcriptional repressor rex rex 0.01
4505 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase bphB 0.01
4447 Hypothetical protein yhfP yhfP 0.01
4472 Glucose 1-dehydrogenase Not Available 0.01
4423 Levodione reductase lvr 0.01
4495 3-oxoacyl-(Acyl carrier protein) reductase TM_1169 0.01
4449 ADP-ribosyltransferase Not Available 0.01
4443 Quinate/shikimate dehydrogenase ydiB 0.01
4475 Hypothetical protein Rv0046c/MT0052 ino1 0.01
3381 Alcohol dehydrogenase Not Available 0.01
4508 Alcohol dehydrogenase adhA 0.01
4448 L-2-hydroxyisocaproate dehydrogenase Not Available 0.01
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.01
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.01
3735 NAD(P) transhydrogenase subunit alpha part 1 pntAA 0.01
4414 Dehydrogenase TT_P0035 0.01
2350 3-isopropylmalate dehydrogenase leuB 0.01
3092 3-isopropylmalate dehydrogenase leuB 0.01
4497 Benzyl alcohol dehydrogenase xylB 0.01
4471 CDP-D-glucose-4,6-dehydratase ascB 0.01
4418 AGR_L_3209p AGR_L_3209 0.01
4507 Alanine dehydrogenase ald 0.01
4506 Myo-inositol-1-phosphate synthase-related protein TM_1419 0.01
4446 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase Not Available 0.01
4466 Glutathione-independent formaldehyde dehydrogenase fdhA 0.01
4456 Inorganic polyphosphate/ATP-NAD kinase ppnK 0.01
4502 Formate dehydrogenase Not Available 0.01
4451 Vip2Ac vip2Ac 0.01
4487 Transcriptional regulator nadR nadR 0.01
4455 Glycerol dehydrogenase gldA 0.01
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.01
3726 D-3-phosphoglycerate dehydrogenase serA 0.01
4291 D-3-phosphoglycerate dehydrogenase serA 0.01
4500 L-lactate dehydrogenase 2 ldh2 0.01
3729 Citrate synthase gltA 0.01
4575 Citrate synthase cit 0.01
4580 Citrate synthase gltA 0.01
4467 Alpha-glucosidase, putative TM_0752 0.01
4427 TDP-glucose-4,6-dehydratase desIV 0.0088
3177 dTDP-glucose 4,6-dehydratase rfbB 0.0088
4499 dTDP-glucose 4,6-dehydratase rmlB 0.0088
4486 Phenol 2-hydroxylase component B pheA2 0.0087
2967 CDP-paratose 2-epimerase rfbE 0.0087
4503 NADPH-flavin oxidoreductase frp 0.0087
4509 Acetoin(diacetyl) reductase budC 0.0087
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0087
6698 Dehydrogenase/reductase SDR family member 4-like 2 DHRS4L2 0.0087
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0087
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0087
4439 Ferredoxin reductase bphA4 0.0087
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.0087
3059 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase fabG3 0.0087
3081 3-dehydroquinate synthase aroB 0.0087
3615 Dihydrodipicolinate reductase dapB 0.0087
3618 Dihydrodipicolinate reductase dapB 0.0087
4462 Dihydrodipicolinate reductase dapB 0.0087
4477 Dihydrolipoyl dehydrogenase lpdV 0.0087
5077 Dihydrolipoyl dehydrogenase Not Available 0.0087
5117 Dihydrolipoyl dehydrogenase lpd 0.0087
1199 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 ART1 0.0087
2336 2,3-diketo-L-gulonate reductase dlgD 0.0087
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.0087
4498 Ornithine cyclodeaminase PP3533 0.0087
2018 Deoxyhypusine synthase DHPS 0.0087
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0087
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.0087
126 D-lactate dehydrogenase dld 0.0087
3545 D-lactate dehydrogenase Not Available 0.0087
4510 D-lactate dehydrogenase ldhA 0.0087
4496 C-terminal-binding protein 1 CTBP1 0.0087
2881 Gamma-aminobutyraldehyde dehydrogenase prr 0.0087
2424 L-lactate dehydrogenase ldh 0.0087
2641 L-lactate dehydrogenase Not Available 0.0087
4437 L-lactate dehydrogenase ldh 0.0087
4442 L-lactate dehydrogenase ldh 0.0087
2591 Urocanate hydratase hutU 0.0087
2507 Diphtheria toxin Not Available 0.0087
4450 Iota toxin component Ia Not Available 0.0087
2683 Mono-ADP-ribosyltransferase C3 C3 0.0081
2799 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Not Available 0.0081
3296 Nicotinamide mononucleotide adenylyltransferase 1 NMNAT1 0.0081
711 UDP-glucose 6-dehydrogenase UGDH 0.0081
3672 UDP-glucose 6-dehydrogenase hasB 0.0081
4318 Siroheme synthase cysG 0.0081
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0081
3367 GDP-mannose 6-dehydrogenase algD 0.0081
4440 NADH peroxidase npr 0.0081
4343 Alpha-glucosidase aglA 0.0081
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.008
816 Biliverdin reductase A BLVRA 0.008
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.008
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.008
4476 Mannitol dehydrogenase mtlD 0.0076
646 Malate dehydrogenase, cytoplasmic MDH1 0.0076
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0076
597 Dihydropteridine reductase QDPR 0.0076
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0076
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0076
396 Alcohol dehydrogenase 4 ADH4 0.0076
328 Sorbitol dehydrogenase SORD 0.0076
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0076
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0076
2617 Nitric oxide synthase oxygenase nos 0.0076
2701 Nitric oxide synthase oxygenase nos 0.0076
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0076
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0076
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0076
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0076
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0076
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0076
3333 Nicotinamide mononucleotide adenylyltransferase 3 NMNAT3 0.0076
3070 Adenosylhomocysteinase AHCY 0.0076
4424 Adenosylhomocysteinase PFE1050w 0.0076
6278 Adenosylhomocysteinase ahcY 0.0076
2826 Glucose--fructose oxidoreductase gfo 0.0076
3191 Histidinol dehydrogenase hisD 0.0076
63 Malate dehydrogenase mdh 0.0074
2329 Malate dehydrogenase mdh 0.0074
3445 Malate dehydrogenase mdh 0.0074
4420 Malate dehydrogenase mdh 0.0074
4438 Malate dehydrogenase mdh 0.0074
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0073
12 Alcohol dehydrogenase class 3 ADH5 0.0073
77 L-lactate dehydrogenase B chain LDHB 0.0073
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0073
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0073
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0073
327 Glutathione reductase gor 0.0072
5110 Glutathione reductase GR2 0.0072
473 L-lactate dehydrogenase A chain LDHA 0.007
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.007
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.007
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.007
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.007
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.007
2286 Isocitrate dehydrogenase [NADP] icd 0.007
2302 Isocitrate dehydrogenase [NADP] icd 0.007
2771 Isocitrate dehydrogenase [NADP] icd 0.007
4491 DNA ligase, NAD-dependent ligA 0.007
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0068
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0068
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0066
251 Alcohol dehydrogenase 1A ADH1A 0.0061
611 Retinal dehydrogenase 1 ALDH1A1 0.0061
569 Retinal dehydrogenase 2 ALDH1A2 0.0061
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0061
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.006
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0059
444 Alcohol dehydrogenase 1B ADH1B 0.0059
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0057
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0057
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0057
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0057
714 Glutathione reductase, mitochondrial GSR 0.0055
517 Alcohol dehydrogenase 1C ADH1C 0.0053
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0052
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