DT-Web

DB03280 - P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate


Identification
Name P1-(5'-Adenosyl)P5-(5'-Thymidyl)Pentaphosphate
Accession Number DB03280 (EXPT02996)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 891.3541
Groups experimental
Monoisotopic Weight 891.008112861
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Thymidylate kinase
Name Thymidylate kinase
Gene Name DTYMK
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.1977
Thymidylate kinase
Name Thymidylate kinase
Gene Name tmk
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.1977
Thymidine kinase
Name Thymidine kinase
Gene Name TK
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.6636
Thymidine kinase
Name Thymidine kinase
Gene Name TK
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.6636
Thymidylate kinase
Name Thymidylate kinase
Gene Name tmk
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.1977

Predictions


Id Partner name Gene Name Score
509 Thymidine kinase TK 1.6636
570 Thymidine kinase TK 1.6636
3430 Thymidine kinase tdk 1.6636
5301 Thymidine kinase tdk 1.6636
5771 Thymidine kinase ORF36 1.6636
7009 Thymidine kinase ORF36 1.6636
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.1359
2257 Uridine phosphorylase udp 0.0981
5132 Uridine phosphorylase udp 0.0981
6171 Solute carrier family 28 member 3 SLC28A3 0.0867
4275 PCZA361.16 Not Available 0.0811
4276 DNA polymerase III subunit epsilon dnaQ 0.0811
1353 DNA topoisomerase 1 TOP1 0.0708
3552 DNA topoisomerase 1 topA 0.0708
6145 Solute carrier family 22 member 1 SLC22A1 0.0663
2632 Adenylosuccinate synthetase purA 0.0459
3323 Adenylosuccinate synthetase purA 0.0459
3975 Adenylosuccinate synthetase ADSS 0.0459
4598 Adenylosuccinate synthetase Adss 0.0459
6817 Adenylosuccinate synthetase purA 0.0459
2756 Geranyltranstransferase ispA 0.0458
2434 NH(3)-dependent NAD(+) synthetase nadE 0.044
2910 NH(3)-dependent NAD(+) synthetase nadE 0.044
3217 NH(3)-dependent NAD(+) synthetase nadE 0.044
24 Thymidylate synthase TMP1 0.0428
359 Thymidylate synthase TYMS 0.0428
2626 Thymidylate synthase thyA 0.0428
2729 Thymidylate synthase thyA 0.0428
5352 Thymidylate synthase THYA 0.0428
2586 Isopentenyl-diphosphate Delta-isomerase idi 0.0415
5187 Isopentenyl-diphosphate delta-isomerase fni 0.0415
5199 Isopentenyl-diphosphate delta-isomerase fni 0.0415
3481 Glucose-1-phosphate thymidylyltransferase 2 rmlA2 0.0392
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.034
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.034
3299 DNA primase/helicase 4 0.0339
2427 Ferrichrome-iron receptor fhuA 0.0318
3244 Ribonucleoside-diphosphate reductase 2 alpha subunit nrdE 0.0313
2633 Anaerobic ribonucleoside-triphosphate reductase NRDD 0.0294
338 DNA polymerase UL30 0.0289
379 DNA polymerase UL54 0.0289
697 DNA polymerase ORF28 0.0289
2482 DNA polymerase 43 0.0289
4104 DNA polymerase BALF5 0.0289
2320 Thymidine kinase, cytosolic TK1 0.0266
6142 Solute carrier family 22 member 8 SLC22A8 0.0168
1729 Solute carrier family 22 member 6 SLC22A6 0.0153
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0152
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0152
5646 Galactokinase GALK1 0.0152
5302 TrwB trwB 0.0152
5265 FtsH ftsH 0.0152
5312 Kinesin-like protein KIF1A KIF1A 0.014
2615 Chemotaxis protein cheA cheA 0.0132
1881 Hexokinase-1 HK1 0.0132
2371 Pantothenate kinase coaA 0.0132
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0132
2892 Acetylglutamate kinase argB 0.0131
3550 Acetylglutamate kinase argB 0.0131
825 Arsenical pump-driving ATPase ASNA1 0.0131
3435 Arsenical pump-driving ATPase arsA 0.0131
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.013
2727 S-adenosylmethionine synthetase metK 0.0126
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0123
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0121
2874 Nitrogenase iron protein 1 nifH1 0.0113
5287 Signaling protein Not Available 0.0113
5304 UPF0166 protein TM_0021 TM_0021 0.0113
5288 Shikimate kinase aroK 0.0113
5283 D-alanine--D-alanine ligase B ddlB 0.0113
3199 Phosphopantetheine adenylyltransferase coaD 0.0113
3543 Phosphopantetheine adenylyltransferase coaD 0.0113
3567 Phosphopantetheine adenylyltransferase coaD 0.0113
5289 Phosphopantetheine adenylyltransferase coaD 0.0113
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0113
5266 Activator of hgdC 0.0113
5292 Putative partitioning protein TT_C1605 0.0113
5293 Shikimate kinase 2 aroL 0.0113
4346 Polynucleotide kinase pseT 0.0113
5281 Plasmid segregation protein parM parM 0.0113
5299 D-alanine--D-alanine ligase ddl 0.0113
6598 D-alanine--D-alanine ligase ddl 0.0113
5276 Chromosomal replication initiator protein dnaA dnaA 0.0113
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0113
5259 Transcriptional regulator ntrC1 0.0113
6699 Transcriptional regulator Cgl2612 0.0113
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0113
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0113
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0113
5291 Glycogen synthase 1 glgA1 0.0113
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0113
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0113
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0113
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0113
5315 Chaperone protein htpG htpG 0.0113
5264 DNA replication protein REP 0.0113
5284 Large T antigen Not Available 0.0113
5277 Preprotein translocase subunit secA secA 0.0113
5308 Preprotein translocase secA 1 subunit secA1 0.0113
5285 Kinesin heavy chain KIF5B 0.0113
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0113
5261 Phosphoribosylformylglycinamidine synthase purL 0.0113
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0112
6143 Solute carrier family 22 member 7 SLC22A7 0.0108
207 Glutathione synthetase GSS 0.0102
5269 Glutathione synthetase gshB 0.0102
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0102
3822 Actin, alpha skeletal muscle ACTA1 0.0101
4106 Guanylate kinase GUK1 0.0098
4516 Guanylate kinase gmk 0.0098
413 Amidophosphoribosyltransferase PPAT 0.0098
2515 Amidophosphoribosyltransferase purF 0.0098
3714 Amidophosphoribosyltransferase purF 0.0098
4837 Cag-alfa cag-alfa 0.0098
4774 NTPase P4 Not Available 0.0098
4839 DNA polymerase III subunit tau dnaX 0.0098
4838 PMS1 protein homolog 2 PMS2 0.0097
5189 Trimethylamine dehydrogenase tmd 0.0097
2270 Dephospho-CoA kinase coaE 0.0097
6277 Heat shock cognate 71 kDa protein HSPA8 0.0097
2284 Adenylate kinase adk 0.0097
2296 Adenylate kinase adk 0.0097
2311 Adenylate kinase adk 0.0097
2312 Adenylate kinase Not Available 0.0097
3470 Hypothetical protein MG245 homolog MPN_348 0.0097
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0097
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0097
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0097
3175 Glutamate--cysteine ligase gshA 0.0097
3426 Glutamine synthetase glnA 0.0097
3987 Glutamine synthetase GLUL 0.0097
1721 Glycogen synthase kinase-3 beta GSK3B 0.0093
2390 Nonsecretory ribonuclease RNASE2 0.009
2683 Mono-ADP-ribosyltransferase C3 C3 0.009
2922 Glycerol kinase glpK 0.009
340 Apoptotic protease-activating factor 1 APAF1 0.0089
5271 Focal adhesion kinase 1 PTK2 0.0089
2282 Protein recA recA 0.0085
2315 Protein recA recA 0.0085
2332 Protein recA recA 0.0085
5263 Protein recA recA 0.0085
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0084
3669 Ribokinase rbsK 0.0084
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0084
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0084
5300 Antigen peptide transporter 1 TAP1 0.0084
408 Riboflavin kinase RFK 0.0083
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.008
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0078
2697 Uridine-cytidine kinase 2 UCK2 0.0078
788 Creatine kinase M-type CKM 0.0078
2334 Dethiobiotin synthetase bioD 0.0077
6555 Dethiobiotin synthetase bioD 0.0077
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0075
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0075
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0075
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0073
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0072
702 UMP-CMP kinase CMPK1 0.0072
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0071
6395 Myosin-14 MYH14 0.0071
48 Pyridoxal kinase PDXK 0.0071
2091 Endoplasmin HSP90B1 0.007
1422 Serine/threonine-protein kinase 6 AURKA 0.0068
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0068
3379 Kinesin-like protein KIF11 KIF11 0.0067
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0066
4178 DNA repair protein RAD51 homolog 1 RAD51 0.0062
5649 Potassium-transporting ATPase B chain kdpB 0.0062
3794 Osmolarity sensor protein envZ envZ 0.0062
5643 General secretion pathway protein E epsE 0.0062
5641 Rod shape-determining protein MreB TM_0588 0.0062
5645 DNA topoisomerase 4 subunit B parE 0.0062
6227 DNA topoisomerase 4 subunit B parE 0.0062
5642 Chaperone clpB clpB 0.0062
5644 Sensor protein phoQ phoQ 0.0062
504 Mast/stem cell growth factor receptor KIT 0.0062
5294 Nucleoside diphosphate kinase A NME1 0.0061
4773 Deoxycytidine kinase DCK 0.0057
5682 Ribonuclease pancreatic RNASE1 0.0056
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0055
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0055
2867 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase ispE 0.0054
6433 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 PFKFB4 0.0054
4751 Mitogen-activated protein kinase 12 MAPK12 0.0054
2397 Dihydroxyacetone kinase dhaK 0.0054
740 Argininosuccinate synthase ASS1 0.0054
865 Argininosuccinate synthase ASS1 0.0054
2680 Argininosuccinate synthase argG 0.0054
3194 Argininosuccinate synthase argG 0.0054
2852 DNA mismatch repair protein mutL mutL 0.0054
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0051
2299 UDP-N-acetylmuramate--L-alanine ligase murC 0.005
3231 Death-associated protein kinase 1 DAPK1 0.0049
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0049
887 DNA gyrase subunit B gyrB 0.0045
4150 DNA gyrase subunit B gyrB 0.0045
6225 DNA gyrase subunit B gyrB 0.0045
936 Ephrin type-A receptor 2 EPHA2 0.0044
958 Insulin-like growth factor 1 receptor IGF1R 0.0041
4192 DNA topoisomerase 2-beta TOP2B 0.0036
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0036
1836 Mitogen-activated protein kinase 10 MAPK10 0.0035
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0033
2236 Casein kinase II subunit alpha CSNK2A1 0.0032
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