DT-Web

DB03811 - Histidinol


Identification
Name Histidinol
Accession Number DB03811 (EXPT01786)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 139.1552
Groups experimental
Monoisotopic Weight 139.074561925
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Histidinol dehydrogenase
Name Histidinol dehydrogenase
Gene Name hisD
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.6687
Histidyl-tRNA synthetase
Name Histidyl-tRNA synthetase
Gene Name hisS
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 1.2446

Predictions


Id Partner name Gene Name Score
3392 Histidyl-tRNA synthetase hisS 1.2446
5410 Unsaturated glucuronyl hydrolase ugl 0.0256
5670 Organic hydroperoxide resistance protein ohr 0.0256
5669 50S ribosomal protein L27 rpmA 0.0256
5675 Chaperone protein torD torD 0.0256
5672 Molybdenum cofactor biosynthesis protein A moaA 0.0255
5676 Axin-1 AXIN1 0.0255
5673 C protein alpha-antigen bca 0.0255
3116 Bacterioferritin bfr 0.0244
4906 Bacterioferritin bfr 0.0244
4965 Bacterioferritin bfr 0.0244
3709 Glycerol uptake facilitator protein glpF 0.0244
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0244
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0244
3238 Multidrug resistance protein mexA mexA 0.0244
3173 Enolase eno 0.0244
3393 TGF-beta receptor type-2 TGFBR2 0.0244
3317 Holo-[acyl-carrier-protein] synthase acpS 0.0223
4381 Holo-[acyl-carrier-protein] synthase acpS 0.0223
3125 Protease synthase and sporulation negative regulatory protein PAI 1 paiA 0.0222
2636 Shikimate dehydrogenase aroE 0.0222
3515 Shikimate dehydrogenase aroE 0.0222
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0222
2852 DNA mismatch repair protein mutL mutL 0.0213
2280 Listeriolysin regulatory protein prfA 0.0205
6579 Calcium/calmodulin-dependent protein kinase type II alpha chain CAMK2A 0.0205
4811 Amylosucrase ams 0.0205
6459 Glycodelin PAEP 0.0196
191 Peptide methionine sulfoxide reductase MSRA 0.0193
909 Maleylacetoacetate isomerase GSTZ1 0.0191
4084 Peptidyl-prolyl cis-trans isomerase B PPIB 0.0188
3221 Cytochrome c4 cc4 0.0185
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0185
740 Argininosuccinate synthase ASS1 0.018
865 Argininosuccinate synthase ASS1 0.018
2680 Argininosuccinate synthase argG 0.018
3194 Argininosuccinate synthase argG 0.018
4692 A/G-specific adenine glycosylase mutY 0.0177
4311 tRNA TRDMT1 0.0176
4325 tRNA trmD 0.0176
4328 tRNA trmD 0.0176
611 Retinal dehydrogenase 1 ALDH1A1 0.0175
2802 Endoglucanase G celCCG 0.0171
6316 ADP-ribosylation factor 1 ARF1 0.0166
444 Alcohol dehydrogenase 1B ADH1B 0.0164
2314 Triosephosphate isomerase TPI 0.0155
3417 Triosephosphate isomerase tpiA 0.0155
3443 Triosephosphate isomerase tpiA 0.0155
6346 Triosephosphate isomerase TPI1 0.0155
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0147
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0141
24 Thymidylate synthase TMP1 0.0138
359 Thymidylate synthase TYMS 0.0138
2626 Thymidylate synthase thyA 0.0138
2729 Thymidylate synthase thyA 0.0138
5352 Thymidylate synthase THYA 0.0138
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0125
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0125
904 Glutathione S-transferase P GSTP1 0.0116
6013 Cytochrome P450 2E1 CYP2E1 0.0069
1588 Multidrug resistance protein 1 ABCB1 0.006
4472 Glucose 1-dehydrogenase Not Available 0.004
4443 Quinate/shikimate dehydrogenase ydiB 0.004
4428 Redox-sensing transcriptional repressor rex rex 0.004
4449 ADP-ribosyltransferase Not Available 0.004
2350 3-isopropylmalate dehydrogenase leuB 0.004
3092 3-isopropylmalate dehydrogenase leuB 0.004
4455 Glycerol dehydrogenase gldA 0.004
4495 3-oxoacyl-(Acyl carrier protein) reductase TM_1169 0.004
4435 L-aspartate dehydrogenase nadX 0.004
4506 Myo-inositol-1-phosphate synthase-related protein TM_1419 0.004
4500 L-lactate dehydrogenase 2 ldh2 0.004
4502 Formate dehydrogenase Not Available 0.004
4446 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase Not Available 0.004
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.004
3726 D-3-phosphoglycerate dehydrogenase serA 0.004
4291 D-3-phosphoglycerate dehydrogenase serA 0.004
4423 Levodione reductase lvr 0.004
3729 Citrate synthase gltA 0.004
4575 Citrate synthase cit 0.004
4580 Citrate synthase gltA 0.004
4505 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase bphB 0.004
4507 Alanine dehydrogenase ald 0.004
4456 Inorganic polyphosphate/ATP-NAD kinase ppnK 0.004
4466 Glutathione-independent formaldehyde dehydrogenase fdhA 0.004
4448 L-2-hydroxyisocaproate dehydrogenase Not Available 0.004
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.004
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.004
3381 Alcohol dehydrogenase Not Available 0.004
4508 Alcohol dehydrogenase adhA 0.004
4471 CDP-D-glucose-4,6-dehydratase ascB 0.004
4418 AGR_L_3209p AGR_L_3209 0.004
4475 Hypothetical protein Rv0046c/MT0052 ino1 0.004
4497 Benzyl alcohol dehydrogenase xylB 0.004
3735 NAD(P) transhydrogenase subunit alpha part 1 pntAA 0.004
4414 Dehydrogenase TT_P0035 0.004
4451 Vip2Ac vip2Ac 0.004
4467 Alpha-glucosidase, putative TM_0752 0.004
4447 Hypothetical protein yhfP yhfP 0.004
4487 Transcriptional regulator nadR nadR 0.004
4486 Phenol 2-hydroxylase component B pheA2 0.0034
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0034
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.0034
3059 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase fabG3 0.0034
2424 L-lactate dehydrogenase ldh 0.0034
2641 L-lactate dehydrogenase Not Available 0.0034
4437 L-lactate dehydrogenase ldh 0.0034
4442 L-lactate dehydrogenase ldh 0.0034
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0034
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0034
4498 Ornithine cyclodeaminase PP3533 0.0034
6698 Dehydrogenase/reductase SDR family member 4-like 2 DHRS4L2 0.0034
4503 NADPH-flavin oxidoreductase frp 0.0034
3615 Dihydrodipicolinate reductase dapB 0.0034
3618 Dihydrodipicolinate reductase dapB 0.0034
4462 Dihydrodipicolinate reductase dapB 0.0034
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0034
4509 Acetoin(diacetyl) reductase budC 0.0034
4439 Ferredoxin reductase bphA4 0.0034
2018 Deoxyhypusine synthase DHPS 0.0034
2393 Maltose-6'-phosphate glucosidase glvA 0.0034
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.0034
1199 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 ART1 0.0034
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.0034
126 D-lactate dehydrogenase dld 0.0034
3545 D-lactate dehydrogenase Not Available 0.0034
4510 D-lactate dehydrogenase ldhA 0.0034
4427 TDP-glucose-4,6-dehydratase desIV 0.0034
2967 CDP-paratose 2-epimerase rfbE 0.0034
3081 3-dehydroquinate synthase aroB 0.0034
4482 UDP-galactose 4-epimerase galE 0.0034
2538 6-phospho-beta-glucosidase bglT bglT 0.0034
4496 C-terminal-binding protein 1 CTBP1 0.0034
4450 Iota toxin component Ia Not Available 0.0034
3177 dTDP-glucose 4,6-dehydratase rfbB 0.0034
4499 dTDP-glucose 4,6-dehydratase rmlB 0.0034
4477 Dihydrolipoyl dehydrogenase lpdV 0.0034
5077 Dihydrolipoyl dehydrogenase Not Available 0.0034
5117 Dihydrolipoyl dehydrogenase lpd 0.0034
2881 Gamma-aminobutyraldehyde dehydrogenase prr 0.0034
2591 Urocanate hydratase hutU 0.0034
2507 Diphtheria toxin Not Available 0.0034
2336 2,3-diketo-L-gulonate reductase dlgD 0.0034
2683 Mono-ADP-ribosyltransferase C3 C3 0.0032
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0032
711 UDP-glucose 6-dehydrogenase UGDH 0.0032
3672 UDP-glucose 6-dehydrogenase hasB 0.0032
3296 Nicotinamide mononucleotide adenylyltransferase 1 NMNAT1 0.0032
4343 Alpha-glucosidase aglA 0.0032
4440 NADH peroxidase npr 0.0032
2799 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Not Available 0.0032
3367 GDP-mannose 6-dehydrogenase algD 0.0032
4318 Siroheme synthase cysG 0.0032
4504 WbpP Not Available 0.0032
4476 Mannitol dehydrogenase mtlD 0.0031
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.003
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.003
3333 Nicotinamide mononucleotide adenylyltransferase 3 NMNAT3 0.003
2434 NH(3)-dependent NAD(+) synthetase nadE 0.003
2910 NH(3)-dependent NAD(+) synthetase nadE 0.003
3217 NH(3)-dependent NAD(+) synthetase nadE 0.003
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.003
3070 Adenosylhomocysteinase AHCY 0.003
4424 Adenosylhomocysteinase PFE1050w 0.003
6278 Adenosylhomocysteinase ahcY 0.003
2826 Glucose--fructose oxidoreductase gfo 0.003
2617 Nitric oxide synthase oxygenase nos 0.003
2701 Nitric oxide synthase oxygenase nos 0.003
816 Biliverdin reductase A BLVRA 0.0029
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0029
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0029
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0029
63 Malate dehydrogenase mdh 0.0029
2329 Malate dehydrogenase mdh 0.0029
3445 Malate dehydrogenase mdh 0.0029
4420 Malate dehydrogenase mdh 0.0029
4438 Malate dehydrogenase mdh 0.0029
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0029
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0029
597 Dihydropteridine reductase QDPR 0.0029
646 Malate dehydrogenase, cytoplasmic MDH1 0.0029
328 Sorbitol dehydrogenase SORD 0.0029
396 Alcohol dehydrogenase 4 ADH4 0.0029
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0029
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0029
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0029
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0029
327 Glutathione reductase gor 0.0029
5110 Glutathione reductase GR2 0.0029
12 Alcohol dehydrogenase class 3 ADH5 0.0028
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0028
77 L-lactate dehydrogenase B chain LDHB 0.0028
2286 Isocitrate dehydrogenase [NADP] icd 0.0028
2302 Isocitrate dehydrogenase [NADP] icd 0.0028
2771 Isocitrate dehydrogenase [NADP] icd 0.0028
4491 DNA ligase, NAD-dependent ligA 0.0028
473 L-lactate dehydrogenase A chain LDHA 0.0027
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0027
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0027
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0027
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0027
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0027
2762 UDP-glucose 4-epimerase GALE 0.0027
3461 UDP-glucose 4-epimerase galE 0.0027
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0026
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0026
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0025
251 Alcohol dehydrogenase 1A ADH1A 0.0024
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0024
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0023
569 Retinal dehydrogenase 2 ALDH1A2 0.0023
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0023
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0022
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0022
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0022
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0022
714 Glutathione reductase, mitochondrial GSR 0.0022
517 Alcohol dehydrogenase 1C ADH1C 0.0021
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0021
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