DT-Web

DB00756 - Hexachlorophene


Identification
Name Hexachlorophene
Accession Number DB00756 (APRD00722)
Type small molecule
Description A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797)
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 406.904
Groups approved
Monoisotopic Weight 403.849895678
Pharmacology
Indication For use as a surgical scrub and a bacteriostatic skin cleanser. It may also be used to control an outbreak of gram-positive infection where other infection control procedures have been unsuccessful.
Mechanism of action The primary mechanism of action of hexachlorophene, based on studies with Bacillus megatherium, is to inhibit the membrane-bound part of the electron transport chain, respiratory D-lactate dehydrogenase. It induces leakage, causes protoplast lysis, and inhibits respiration.
Absorption Detectable blood levels of hexachlorophene following absorption through intact skin have been found in subjects who regularly scrubbed with hexachlorophene.
Protein binding 92%
Biotransformation Not Available
Route of elimination Not Available
Toxicity Oral, rat LD50: 66 mg/kg. Signs of overdose include anorexia, vomiting, abdominal cramps, diarrhea, dehydration, convulsions, hypotension, and shock, and in several reported instances, fatalities.
Affected organisms
  • Enteric bacteria and other eubacteria
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


D-lactate dehydrogenase
Name D-lactate dehydrogenase
Gene Name dld
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Wang JL, Buhler DR: Inhibition of dehydrogenase enzymes by hexachlorophene. Biochem Pharmacol. 1978;27(24):2947-53. - Pubmed
DTHybrid score 0.5045
Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
Name Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial
Gene Name SDHD
Pharmacological action yes
Actions inhibitor
References
  • Lokanatha V, Sailaja P, Rajendra W: In vitro kinetics of the rat brain succinate dehydrogenase inhibition by hexachlorophene. J Biochem Mol Toxicol. 1999;13(6):303-6. - Pubmed
DTHybrid score 0.4662
Glutamate dehydrogenase 1, mitochondrial
Name Glutamate dehydrogenase 1, mitochondrial
Gene Name GLUD1
Pharmacological action unknown
Actions inhibitor
References
  • Li M, Smith CJ, Walker MT, Smith TJ: Novel inhibitors complexed with glutamate dehydrogenase: allosteric regulation by control of protein dynamics. J Biol Chem. 2009 Aug 21;284(34):22988-3000. Epub 2009 Jun 15. - Pubmed
  • Wang JL, Buhler DR: Inhibition of dehydrogenase enzymes by hexachlorophene. Biochem Pharmacol. 1978;27(24):2947-53. - Pubmed
DTHybrid score 0.4195

Predictions


Id Partner name Gene Name Score
3545 D-lactate dehydrogenase Not Available 0.5045
4510 D-lactate dehydrogenase ldhA 0.5045
4006 Succinate dehydrogenase cytochrome b560 subunit, mitochondrial SDHC 0.0625
4001 Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial SDHB 0.0622
197 Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SDHA 0.0574
6890 Hypothetical membrane spanning protein TT_C0153 0.0344
6886 Thiol:disulfide interchange protein dsbA dsbA 0.0344
6888 NrfC protein nrfC 0.0344
6889 Thiosulfate reductase TT_C0155 0.0343
6887 Disulfide bond formation protein B dsbB 0.03
6389 Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial ETFDH 0.0299
6353 Reaction center protein L chain pufL 0.0229
6454 Reaction center protein L chain pufL 0.0229
6683 Reaction center protein L chain pufL 0.0229
6354 Reaction center protein M chain pufM 0.0228
6455 Reaction center protein M chain pufM 0.0228
6684 Reaction center protein M chain pufM 0.0228
6352 Reaction center protein H chain puhA 0.0228
6456 Reaction center protein H chain puhA 0.0228
6682 Reaction center protein H chain puhA 0.0228
6351 Photosynthetic reaction center cytochrome c subunit pufC 0.0228
1673 GTP cyclohydrolase I GCH1 0.0225
3302 GTP cyclohydrolase I folE 0.0225
3209 Ornithine decarboxylase, inducible odcI 0.0225
6359 Cytochrome b-c1 complex subunit 8 UQCRQ 0.02
6358 Cytochrome b-c1 complex subunit 6, mitochondrial UQCRH 0.02
6357 Cytochrome b-c1 complex subunit 2, mitochondrial UQCRC2 0.0199
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0197
3335 Probable GTP-binding protein engB engB 0.0196
3354 Ras-related protein Rap-2a RAP2A 0.0196
6363 Cytochrome b-c1 complex subunit 9 UQCR10 0.0195
6362 Cytochrome b-c1 complex subunit 7 UQCRB 0.0195
3311 mRNA-capping enzyme A103R 0.0195
6356 Cytochrome c1, heme protein, mitochondrial CYC1 0.0195
1495 Ubiquinol-cytochrome-c reductase complex core protein 1, mitochondrial UQCRC1 0.0195
1227 Cytochrome b MT-CYB 0.0195
6386 Cytochrome b petB 0.0195
6937 Cytochrome b MT-CYB 0.0195
6360 Cytochrome b-c1 complex subunit Rieske, mitochondrial UQCRFS1 0.0195
2647 RNA-directed RNA polymerase P2 0.0193
237 Histo-blood group ABO system transferase ABO 0.0179
1750 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 1 PFKFB1 0.0161
1758 GTPase HRas HRAS 0.016
6316 ADP-ribosylation factor 1 ARF1 0.015
3978 Adenylosuccinate synthetase isozyme 1 ADSSL1 0.015
4002 Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial SUCLG1 0.0145
498 Solute carrier family 13 member 2 SLC13A2 0.0145
4008 Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial OXCT2 0.0145
1410 Oxidoreductase HSD17B6 0.0145
4725 Oxidoreductase Not Available 0.0145
5124 Oxidoreductase Not Available 0.0145
391 Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial SUCLG2 0.0145
4009 Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial SUCLA2 0.0145
4010 Mitochondrial dicarboxylate carrier SLC25A10 0.0145
4007 Succinate receptor 1 SUCNR1 0.0145
25 Solute carrier family 13 member 1 SLC13A1 0.0145
673 Solute carrier family 13 member 3 SLC13A3 0.0145
4003 Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial OXCT1 0.0138
585 Aspartyl/asparaginyl beta-hydroxylase ASPH 0.0124
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0122
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0122
4000 Prolyl 4-hydroxylase subunit alpha-2 P4HA2 0.012
3940 Gamma-butyrobetaine dioxygenase BBOX1 0.0119
3964 Trimethyllysine dioxygenase, mitochondrial TMLHE 0.0119
97 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 PLOD1 0.0119
3938 Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 PLOD3 0.0119
4486 Phenol 2-hydroxylase component B pheA2 0.0119
4439 Ferredoxin reductase bphA4 0.0119
4477 Dihydrolipoyl dehydrogenase lpdV 0.0119
5077 Dihydrolipoyl dehydrogenase Not Available 0.0119
5117 Dihydrolipoyl dehydrogenase lpd 0.0119
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0116
2297 Genome polyprotein Not Available 0.0114
2322 Genome polyprotein Not Available 0.0114
2694 Genome polyprotein Not Available 0.0114
2719 Genome polyprotein Not Available 0.0114
2860 Genome polyprotein Not Available 0.0114
2928 Genome polyprotein Not Available 0.0114
3160 Genome polyprotein Not Available 0.0114
3260 Genome polyprotein Not Available 0.0114
4783 Genome polyprotein Not Available 0.0114
5726 Genome polyprotein Not Available 0.0114
5779 Genome polyprotein Not Available 0.0114
5867 Genome polyprotein Not Available 0.0114
6253 Genome polyprotein Not Available 0.0114
6301 Genome polyprotein Not Available 0.0114
6380 Genome polyprotein Not Available 0.0114
6381 Genome polyprotein Not Available 0.0114
6437 Genome polyprotein Not Available 0.0114
6520 Genome polyprotein Not Available 0.0114
6521 Genome polyprotein Not Available 0.0114
6652 Genome polyprotein Not Available 0.0114
6734 Genome polyprotein Not Available 0.0114
6735 Genome polyprotein Not Available 0.0114
6736 Genome polyprotein Not Available 0.0114
6737 Genome polyprotein Not Available 0.0114
6738 Genome polyprotein Not Available 0.0114
6739 Genome polyprotein Not Available 0.0114
6744 Genome polyprotein Not Available 0.0114
6748 Genome polyprotein Not Available 0.0114
6894 Genome polyprotein Not Available 0.0114
6898 Genome polyprotein Not Available 0.0114
3951 Prolyl 3-hydroxylase 3 LEPREL2 0.0108
3949 Prolyl 3-hydroxylase 2 LEPREL1 0.0108
3945 Prolyl 3-hydroxylase 1 LEPRE1 0.0108
4440 NADH peroxidase npr 0.0105
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.01
327 Glutathione reductase gor 0.0099
5110 Glutathione reductase GR2 0.0099
5115 FkbI fkbI 0.0098
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0098
3763 5,10-methylenetetrahydrofolate reductase metF 0.0098
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0098
5094 5,10-methylenetetrahydrofolate reductase metF 0.0098
526 Thioredoxin reductase trxB 0.0098
3767 Thioredoxin reductase trxB 0.0098
5078 Amine oxidase, flavin-containing PSPTO1126 0.0098
5122 Mersacidin decarboxylase mrsD 0.0098
5081 L-aspartate oxidase nadB 0.0098
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0098
3133 UDP-galactopyranose mutase glf 0.0098
5099 UDP-galactopyranose mutase glf 0.0098
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0098
5095 Putidaredoxin reductase camA 0.0098
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0098
5083 Cryptochrome DASH cry 0.0098
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0098
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0098
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0098
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0098
5111 Phenylacetone monooxygenase pamO 0.0098
5109 Outer membrane protein p64k or PM-6 m-6 0.0098
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0094
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0094
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0086
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0086
3594 Deoxyribodipyrimidine photo-lyase phr 0.0086
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0086
5080 Deoxyribodipyrimidine photo-lyase phr 0.0086
5073 Ferredoxin--NADP reductase petH 0.0085
5076 Ferredoxin--NADP reductase fpr 0.0085
5119 Ferredoxin--NADP reductase petH 0.0085
5121 Ferredoxin--NADP reductase fpr 0.0085
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0085
2470 Pyruvate oxidase pox5 0.0085
5072 N,N-dimethylglycine oxidase dmg 0.0085
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0085
2526 NADPH-ferredoxin reductase fprA fprA 0.0085
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0085
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0085
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0085
3102 Flavohemoprotein hmp 0.0085
4969 Flavohemoprotein hmp 0.0085
2268 Cholesterol oxidase choB 0.0085
2822 Cholesterol oxidase choA 0.0085
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0085
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0085
714 Glutathione reductase, mitochondrial GSR 0.0083
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0078
2893 Glycine oxidase thiO 0.0078
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0078
605 Fumarate reductase flavoprotein subunit frdA 0.0075
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0075
3673 Fumarate reductase flavoprotein subunit fccA 0.0075
4912 Fumarate reductase flavoprotein subunit ifcA 0.0075
6549 Fumarate reductase flavoprotein subunit frdA 0.0075
2567 Thymidylate synthase thyX thyX 0.0075
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0075
2823 Trypanothione reductase TPR 0.0074
2769 P-hydroxybenzoate hydroxylase pobA 0.0073
2809 P-hydroxybenzoate hydroxylase pobA 0.0073
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0069
2380 Monomeric sarcosine oxidase soxA 0.0068
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0067
6645 D-amino-acid oxidase DAO 0.0066
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0061
6142 Solute carrier family 22 member 8 SLC22A8 0.0057
3947 Xanthine dehydrogenase/oxidase XDH 0.0055
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0053
76 Nitric-oxide synthase, brain NOS1 0.0051
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0051
4120 NADPH--cytochrome P450 reductase POR 0.0051
2683 Mono-ADP-ribosyltransferase C3 C3 0.005
4024 Mitochondrial glutamate carrier 2 SLC25A18 0.0045
4025 Mitochondrial glutamate carrier 1 SLC25A22 0.0045
4026 Aspartyl aminopeptidase DNPEP 0.0045
915 Delta 1-pyrroline-5-carboxylate synthetase ALDH18A1 0.0045
4022 Glutamate--ammonia ligase domain-containing protein 1 LGSN 0.0045
4021 Probable glutamyl-tRNA synthetase, mitochondrial EARS2 0.0045
4023 N-acetylglutamate synthase, mitochondrial NAGS 0.0045
1912 Excitatory amino acid transporter 1 SLC1A3 0.0045
4016 Excitatory amino acid transporter 5 SLC1A7 0.0045
4019 Excitatory amino acid transporter 4 SLC1A6 0.0045
1047 Excitatory amino acid transporter 2 SLC1A2 0.0045
927 Metabotropic glutamate receptor 8 GRM8 0.0045
664 Glutamate decarboxylase 2 GAD2 0.0045
3890 Glutamate decarboxylase 2 GAD2 0.0045
926 Metabotropic glutamate receptor 7 GRM7 0.0045
4018 Glutamate receptor delta-2 subunit GRID2 0.0045
4027 Glutamate receptor delta-1 subunit GRID1 0.0045
4017 5-oxoprolinase OPLAH 0.0045
922 Glutamate receptor 4 GRIA4 0.0045
925 Metabotropic glutamate receptor 4 GRM4 0.0045
924 Glutamate receptor, ionotropic kainate 3 GRIK3 0.0045
919 Glutamate receptor, ionotropic kainate 4 GRIK4 0.0045
4020 Glutamyl aminopeptidase ENPEP 0.0045
920 Glutamate receptor, ionotropic kainate 5 GRIK5 0.0045
816 Biliverdin reductase A BLVRA 0.0045
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0045
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0045
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0045
3939 Amine oxidase [flavin-containing] B MAOB 0.0043
3941 Amine oxidase [flavin-containing] A MAOA 0.0041
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.004
646 Malate dehydrogenase, cytoplasmic MDH1 0.004
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.004
363 NADP-dependent malic enzyme, mitochondrial ME3 0.004
328 Sorbitol dehydrogenase SORD 0.0039
597 Dihydropteridine reductase QDPR 0.0039
396 Alcohol dehydrogenase 4 ADH4 0.0039
3984 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L 0.0039
5 Glutaminase liver isoform, mitochondrial GLS2 0.0039
917 Glutaminase kidney isoform, mitochondrial GLS 0.0039
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0039
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0039
3991 Glutamine-dependent NAD(+) synthetase NADSYN1 0.0039
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0039
5261 Phosphoribosylformylglycinamidine synthase purL 0.0039
668 Glutamate--cysteine ligase regulatory subunit GCLM 0.0039
3895 Kynurenine--oxoglutarate transaminase 3 CCBL2 0.0038
665 Phosphoserine aminotransferase PSAT1 0.0038
4652 Phosphoserine aminotransferase serC 0.0038
801 Kynurenine/alpha-aminoadipate aminotransferase mitochondrial AADAT 0.0038
5304 UPF0166 protein TM_0021 TM_0021 0.0038
420 Glutamate decarboxylase 1 GAD1 0.0038
3900 Glutamate decarboxylase 1 GAD1 0.0038
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0038
5293 Shikimate kinase 2 aroL 0.0038
5288 Shikimate kinase aroK 0.0038
5287 Signaling protein Not Available 0.0038
5292 Putative partitioning protein TT_C1605 0.0038
5266 Activator of hgdC 0.0038
3199 Phosphopantetheine adenylyltransferase coaD 0.0038
3543 Phosphopantetheine adenylyltransferase coaD 0.0038
3567 Phosphopantetheine adenylyltransferase coaD 0.0038
5289 Phosphopantetheine adenylyltransferase coaD 0.0038
2874 Nitrogenase iron protein 1 nifH1 0.0038
5283 D-alanine--D-alanine ligase B ddlB 0.0038
5281 Plasmid segregation protein parM parM 0.0038
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0038
5299 D-alanine--D-alanine ligase ddl 0.0038
6598 D-alanine--D-alanine ligase ddl 0.0038
5276 Chromosomal replication initiator protein dnaA dnaA 0.0038
5259 Transcriptional regulator ntrC1 0.0038
6699 Transcriptional regulator Cgl2612 0.0038
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0038
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0038
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0038
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0038
5291 Glycogen synthase 1 glgA1 0.0038
4346 Polynucleotide kinase pseT 0.0038
5264 DNA replication protein REP 0.0038
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0038
5308 Preprotein translocase secA 1 subunit secA1 0.0038
5285 Kinesin heavy chain KIF5B 0.0038
5315 Chaperone protein htpG htpG 0.0038
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0038
5284 Large T antigen Not Available 0.0038
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0038
5277 Preprotein translocase subunit secA secA 0.0038
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0038
625 Glutamate carboxypeptidase 2 FOLH1 0.0037
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0037
12 Alcohol dehydrogenase class 3 ADH5 0.0037
77 L-lactate dehydrogenase B chain LDHB 0.0037
916 Metabotropic glutamate receptor 1 GRM1 0.0036
923 Glutamate receptor 3 GRIA3 0.0036
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0035
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0035
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0035
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0035
186 Glutamate--cysteine ligase catalytic subunit GCLC 0.0035
1671 Excitatory amino acid transporter 3 SLC1A1 0.0035
3877 Growth-inhibiting protein 18 GIG18 0.0035
569 Retinal dehydrogenase 2 ALDH1A2 0.0035
473 L-lactate dehydrogenase A chain LDHA 0.0035
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0035
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0034
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0034
914 Formimidoyltransferase-cyclodeaminase FTCD 0.0034
426 Aspartate aminotransferase, mitochondrial GOT2 0.0034
210 Bifunctional aminoacyl-tRNA synthetase [Includes: Glutamyl-tRNA synthetase EPRS 0.0033
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0033
611 Retinal dehydrogenase 1 ALDH1A1 0.0033
763 Tyrosine aminotransferase TAT 0.0033
5493 Tyrosine aminotransferase Not Available 0.0033
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0033
735 Alanine aminotransferase 1 GPT 0.0033
3904 Alanine aminotransferase 2 GPT2 0.0033
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0033
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0033
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0032
586 Aspartate aminotransferase, cytoplasmic GOT1 0.0032
251 Alcohol dehydrogenase 1A ADH1A 0.0032
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0031
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0031
4837 Cag-alfa cag-alfa 0.0031
4839 DNA polymerase III subunit tau dnaX 0.0031
4838 PMS1 protein homolog 2 PMS2 0.0031
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0031
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0031
5302 TrwB trwB 0.0031
5646 Galactokinase GALK1 0.0031
5265 FtsH ftsH 0.0031
4106 Guanylate kinase GUK1 0.0031
4516 Guanylate kinase gmk 0.0031
6277 Heat shock cognate 71 kDa protein HSPA8 0.0031
413 Amidophosphoribosyltransferase PPAT 0.003
2515 Amidophosphoribosyltransferase purF 0.003
3714 Amidophosphoribosyltransferase purF 0.003
795 Branched-chain-amino-acid aminotransferase, mitochondrial BCAT2 0.003
5189 Trimethylamine dehydrogenase tmd 0.003
4774 NTPase P4 Not Available 0.003
340 Apoptotic protease-activating factor 1 APAF1 0.003
3175 Glutamate--cysteine ligase gshA 0.003
3426 Glutamine synthetase glnA 0.003
3987 Glutamine synthetase GLUL 0.003
2270 Dephospho-CoA kinase coaE 0.003
2284 Adenylate kinase adk 0.003
2296 Adenylate kinase adk 0.003
2311 Adenylate kinase adk 0.003
2312 Adenylate kinase Not Available 0.003
3470 Hypothetical protein MG245 homolog MPN_348 0.003
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.003
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.003
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.003
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.003
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.003
705 Glutamate receptor 1 GRIA1 0.003
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.003
33 Cystine/glutamate transporter SLC7A11 0.003
574 Branched-chain-amino-acid aminotransferase, cytosolic BCAT1 0.003
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.003
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.003
5300 Antigen peptide transporter 1 TAP1 0.0029
444 Alcohol dehydrogenase 1B ADH1B 0.0029
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0029
4495 3-oxoacyl-(Acyl carrier protein) reductase TM_1169 0.0029
4435 L-aspartate dehydrogenase nadX 0.0029
4428 Redox-sensing transcriptional repressor rex rex 0.0029
4449 ADP-ribosyltransferase Not Available 0.0029
4414 Dehydrogenase TT_P0035 0.0029
2350 3-isopropylmalate dehydrogenase leuB 0.0029
3092 3-isopropylmalate dehydrogenase leuB 0.0029
4455 Glycerol dehydrogenase gldA 0.0029
4497 Benzyl alcohol dehydrogenase xylB 0.0029
4466 Glutathione-independent formaldehyde dehydrogenase fdhA 0.0029
4446 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase Not Available 0.0029
4472 Glucose 1-dehydrogenase Not Available 0.0029
4423 Levodione reductase lvr 0.0029
4505 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase bphB 0.0029
4443 Quinate/shikimate dehydrogenase ydiB 0.0029
4456 Inorganic polyphosphate/ATP-NAD kinase ppnK 0.0029
4448 L-2-hydroxyisocaproate dehydrogenase Not Available 0.0029
4500 L-lactate dehydrogenase 2 ldh2 0.0029
4447 Hypothetical protein yhfP yhfP 0.0029
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.0029
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.0029
3381 Alcohol dehydrogenase Not Available 0.0029
4508 Alcohol dehydrogenase adhA 0.0029
4418 AGR_L_3209p AGR_L_3209 0.0029
4507 Alanine dehydrogenase ald 0.0029
4475 Hypothetical protein Rv0046c/MT0052 ino1 0.0029
4506 Myo-inositol-1-phosphate synthase-related protein TM_1419 0.0029
3735 NAD(P) transhydrogenase subunit alpha part 1 pntAA 0.0029
4502 Formate dehydrogenase Not Available 0.0029
4487 Transcriptional regulator nadR nadR 0.0029
3729 Citrate synthase gltA 0.0029
4575 Citrate synthase cit 0.0029
4580 Citrate synthase gltA 0.0029
4451 Vip2Ac vip2Ac 0.0029
4467 Alpha-glucosidase, putative TM_0752 0.0029
4471 CDP-D-glucose-4,6-dehydratase ascB 0.0029
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0028
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0028
5312 Kinesin-like protein KIF1A KIF1A 0.0027
2390 Nonsecretory ribonuclease RNASE2 0.0027
2282 Protein recA recA 0.0027
2315 Protein recA recA 0.0027
2332 Protein recA recA 0.0027
5263 Protein recA recA 0.0027
2922 Glycerol kinase glpK 0.0027
5271 Focal adhesion kinase 1 PTK2 0.0027
408 Riboflavin kinase RFK 0.0027
2615 Chemotaxis protein cheA cheA 0.0025
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0025
2892 Acetylglutamate kinase argB 0.0025
3550 Acetylglutamate kinase argB 0.0025
2371 Pantothenate kinase coaA 0.0025
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0025
517 Alcohol dehydrogenase 1C ADH1C 0.0025
1881 Hexokinase-1 HK1 0.0025
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0025
3669 Ribokinase rbsK 0.0025
825 Arsenical pump-driving ATPase ASNA1 0.0025
3435 Arsenical pump-driving ATPase arsA 0.0025
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0025
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0025
788 Creatine kinase M-type CKM 0.0024
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0024
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0024
738 Monocarboxylate transporter 1 SLC16A1 0.0024
2727 S-adenosylmethionine synthetase metK 0.0024
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0024
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0023
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0023
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0023
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0023
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0023
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0023
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0023
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0023
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0023
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0023
2697 Uridine-cytidine kinase 2 UCK2 0.0023
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0023
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0023
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0023
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0023
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0023
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0023
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0023
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0023
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0023
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0023
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0023
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0023
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0023
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0023
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0023
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0023
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0023
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0023
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0023
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0023
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0023
167 L-lactate dehydrogenase C chain LDHC 0.0023
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0023
206 3-keto-steroid reductase HSD17B7 0.0023
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0023
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0023
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0023
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0023
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0023
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0023
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0023
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0023
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0023
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0023
107 C-4 methylsterol oxidase SC4MOL 0.0023
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0023
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0023
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0023
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0023
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0023
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0023
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0023
644 Heme oxygenase 2 HMOX2 0.0023
4982 Heme oxygenase 2 pbsA2 0.0023
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0023
729 GDP-L-fucose synthetase TSTA3 0.0023
3463 GDP-L-fucose synthetase fcl 0.0023
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0023
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0023
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0023
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0023
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0023
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0023
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0023
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0023
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0023
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0023
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0023
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0023
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0023
34 7-dehydrocholesterol reductase DHCR7 0.0023
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.0023
711 UDP-glucose 6-dehydrogenase UGDH 0.0023
3672 UDP-glucose 6-dehydrogenase hasB 0.0023
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0023
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0023
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0023
3726 D-3-phosphoglycerate dehydrogenase serA 0.0023
4291 D-3-phosphoglycerate dehydrogenase serA 0.0023
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0023
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0023
643 Peroxisomal bifunctional enzyme EHHADH 0.0023
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0023
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0023
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0023
4427 TDP-glucose-4,6-dehydratase desIV 0.0023
3177 dTDP-glucose 4,6-dehydratase rfbB 0.0023
4499 dTDP-glucose 4,6-dehydratase rmlB 0.0023
4503 NADPH-flavin oxidoreductase frp 0.0023
4482 UDP-galactose 4-epimerase galE 0.0023
2967 CDP-paratose 2-epimerase rfbE 0.0023
3081 3-dehydroquinate synthase aroB 0.0023
2334 Dethiobiotin synthetase bioD 0.0023
6555 Dethiobiotin synthetase bioD 0.0023
2507 Diphtheria toxin Not Available 0.0023
3615 Dihydrodipicolinate reductase dapB 0.0023
3618 Dihydrodipicolinate reductase dapB 0.0023
4462 Dihydrodipicolinate reductase dapB 0.0023
2336 2,3-diketo-L-gulonate reductase dlgD 0.0023
2591 Urocanate hydratase hutU 0.0023
2538 6-phospho-beta-glucosidase bglT bglT 0.0023
2393 Maltose-6'-phosphate glucosidase glvA 0.0023
4496 C-terminal-binding protein 1 CTBP1 0.0023
1199 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 ART1 0.0023
2424 L-lactate dehydrogenase ldh 0.0023
2641 L-lactate dehydrogenase Not Available 0.0023
4437 L-lactate dehydrogenase ldh 0.0023
4442 L-lactate dehydrogenase ldh 0.0023
6698 Dehydrogenase/reductase SDR family member 4-like 2 DHRS4L2 0.0023
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.0022
4509 Acetoin(diacetyl) reductase budC 0.0022
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0022
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.0022
3059 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase fabG3 0.0022
2018 Deoxyhypusine synthase DHPS 0.0022
4498 Ornithine cyclodeaminase PP3533 0.0022
4450 Iota toxin component Ia Not Available 0.0022
2881 Gamma-aminobutyraldehyde dehydrogenase prr 0.0022
48 Pyridoxal kinase PDXK 0.0022
207 Glutathione synthetase GSS 0.0022
5269 Glutathione synthetase gshB 0.0022
6151 Monocarboxylate transporter 10 SLC16A10 0.0022
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0022
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0022
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0022
63 Malate dehydrogenase mdh 0.0022
2329 Malate dehydrogenase mdh 0.0022
3445 Malate dehydrogenase mdh 0.0022
4420 Malate dehydrogenase mdh 0.0022
4438 Malate dehydrogenase mdh 0.0022
4476 Mannitol dehydrogenase mtlD 0.0022
702 UMP-CMP kinase CMPK1 0.0021
921 Glutamate receptor 2 GRIA2 0.0021
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0021
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0021
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.0021
2091 Endoplasmin HSP90B1 0.0021
2251 Thymidylate kinase tmk 0.0021
2254 Thymidylate kinase DTYMK 0.0021
3522 Thymidylate kinase tmk 0.0021
6395 Myosin-14 MYH14 0.002
3296 Nicotinamide mononucleotide adenylyltransferase 1 NMNAT1 0.002
4504 WbpP Not Available 0.002
4318 Siroheme synthase cysG 0.002
3367 GDP-mannose 6-dehydrogenase algD 0.002
4343 Alpha-glucosidase aglA 0.002
2799 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Not Available 0.002
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.002
666 NADP-dependent malic enzyme ME1 0.002
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.002
857 Malate dehydrogenase, mitochondrial MDH2 0.002
1422 Serine/threonine-protein kinase 6 AURKA 0.002
2617 Nitric oxide synthase oxygenase nos 0.002
2701 Nitric oxide synthase oxygenase nos 0.002
504 Mast/stem cell growth factor receptor KIT 0.0019
3379 Kinesin-like protein KIF11 KIF11 0.0019
6026 Alcohol dehydrogenase 6 ADH6 0.0019
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0019
626 Cysteine dioxygenase type 1 CDO1 0.0019
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0019
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0019
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0019
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0019
3333 Nicotinamide mononucleotide adenylyltransferase 3 NMNAT3 0.0019
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0019
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0019
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0019
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0019
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0019
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0019
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0019
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0019
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0019
3070 Adenosylhomocysteinase AHCY 0.0019
4424 Adenosylhomocysteinase PFE1050w 0.0019
6278 Adenosylhomocysteinase ahcY 0.0019
2826 Glucose--fructose oxidoreductase gfo 0.0019
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0019
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0019
627 11-cis retinol dehydrogenase RDH5 0.0019
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0019
3191 Histidinol dehydrogenase hisD 0.0019
3822 Actin, alpha skeletal muscle ACTA1 0.0018
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0018
509 Thymidine kinase TK 0.0018
570 Thymidine kinase TK 0.0018
2559 Thymidine kinase TK 0.0018
3430 Thymidine kinase tdk 0.0018
3518 Thymidine kinase TK 0.0018
5301 Thymidine kinase tdk 0.0018
5771 Thymidine kinase ORF36 0.0018
7009 Thymidine kinase ORF36 0.0018
4773 Deoxycytidine kinase DCK 0.0018
5294 Nucleoside diphosphate kinase A NME1 0.0018
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0018
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0018
13 Aminomethyltransferase, mitochondrial AMT 0.0018
1721 Glycogen synthase kinase-3 beta GSK3B 0.0017
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0017
2286 Isocitrate dehydrogenase [NADP] icd 0.0017
2302 Isocitrate dehydrogenase [NADP] icd 0.0017
2771 Isocitrate dehydrogenase [NADP] icd 0.0017
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0017
4491 DNA ligase, NAD-dependent ligA 0.0017
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0017
2762 UDP-glucose 4-epimerase GALE 0.0016
3461 UDP-glucose 4-epimerase galE 0.0016
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0016
5682 Ribonuclease pancreatic RNASE1 0.0016
279 Tyrosinase TYR 0.0016
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0016
654 Flavin reductase BLVRB 0.0015
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
810 Heme oxygenase 1 HMOX1 0.0014
3391 Heme oxygenase 1 pbsA1 0.0014
380 Cytochrome P450 17A1 CYP17A1 0.0014
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0014
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0014
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0014
468 Cytochrome P450 4A11 CYP4A11 0.0013
6020 Aldehyde oxidase AOX1 0.0012
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0012
822 Aldose reductase AKR1B1 0.0011
365 Dihydrofolate reductase DHFR 0.0011
2381 Dihydrofolate reductase DFR1 0.0011
2833 Dihydrofolate reductase Not Available 0.0011
2931 Dihydrofolate reductase folA 0.0011
3544 Dihydrofolate reductase folA 0.0011
3682 Dihydrofolate reductase folA 0.0011
6642 Dihydrofolate reductase folA 0.0011
6756 Dihydrofolate reductase dfrA 0.0011
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