DT-Web: DB02659

Identification
Name	Cholic Acid
Accession Number	DB02659 (EXPT00906)
Type	small molecule
Description	A major primary bile acid produced in the liver and usually conjugated with glycine or taurine. It facilitates fat absorption and cholesterol excretion. [PubChem]
Structure	MOL SDF PDB SMILES InChI
Categories ^(*)
Molecular Weight	408.5714
Groups	experimental
Monoisotopic Weight	408.28757439
Pharmacology
Indication	Not Available
Mechanism of action	Not Available
Absorption	Not Available
Protein binding	Not Available
Biotransformation	Not Available
Route of elimination	Not Available
Toxicity	Not Available
Affected organisms	Not Available
Interactions
Drug Interactions	Not Available
Food Interactions	Not Available

Ferrochelatase, mitochondrial
Name	Ferrochelatase, mitochondrial
Gene Name	FECH
Pharmacological action	unknown
Actions	Not Available
References	Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.5743
Alcohol dehydrogenase 1C
Name	Alcohol dehydrogenase 1C
Gene Name	ADH1C
Pharmacological action	unknown
Actions	Not Available
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	1.5145
Estrogen-related receptor gamma
Name	Estrogen-related receptor gamma
Gene Name	ESRRG
Pharmacological action	unknown
Actions	Not Available
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	1.2365
Gastrotropin
Name	Gastrotropin
Gene Name	FABP6
Pharmacological action	unknown
Actions	Not Available
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.7071
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Name	Cytochrome c oxidase subunit 4 isoform 1, mitochondrial
Gene Name	COX4I1
Pharmacological action	unknown
Actions	Not Available
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.7426
Cytochrome c oxidase subunit 1
Name	Cytochrome c oxidase subunit 1
Gene Name	MT-CO1
Pharmacological action	unknown
Actions	Not Available
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.7417
Cytochrome c oxidase subunit 2
Name	Cytochrome c oxidase subunit 2
Gene Name	MT-CO2
Pharmacological action	unknown
Actions	Not Available
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.7423
Cytochrome c oxidase subunit 3
Name	Cytochrome c oxidase subunit 3
Gene Name	MT-CO3
Pharmacological action	unknown
Actions	Not Available
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.7422
Cytochrome c oxidase subunit 5A, mitochondrial
Name	Cytochrome c oxidase subunit 5A, mitochondrial
Gene Name	COX5A
Pharmacological action	unknown
Actions	Not Available
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.7429
Cytochrome c oxidase subunit 5B, mitochondrial
Name	Cytochrome c oxidase subunit 5B, mitochondrial
Gene Name	COX5B
Pharmacological action	unknown
Actions	Not Available
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	Not Available
Cytochrome c oxidase subunit 6C
Name	Cytochrome c oxidase subunit 6C
Gene Name	COX6C
Pharmacological action	unknown
Actions	Not Available
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.7436
Cytochrome c oxidase subunit 7B, mitochondrial
Name	Cytochrome c oxidase subunit 7B, mitochondrial
Gene Name	COX7B
Pharmacological action	unknown
Actions	Not Available
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.7432
Cytochrome c oxidase subunit 7C, mitochondrial
Name	Cytochrome c oxidase subunit 7C, mitochondrial
Gene Name	COX7C
Pharmacological action	unknown
Actions	Not Available
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.7435
Cytochrome c oxidase subunit 8A, mitochondrial
Name	Cytochrome c oxidase subunit 8A, mitochondrial
Gene Name	COX8A
Pharmacological action	unknown
Actions	Not Available
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.7437
Cytochrome c oxidase subunit 6A2, mitochondrial
Name	Cytochrome c oxidase subunit 6A2, mitochondrial
Gene Name	COX6A2
Pharmacological action	unknown
Actions	Not Available
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.7433
Cytochrome c oxidase subunit 6B1
Name	Cytochrome c oxidase subunit 6B1
Gene Name	COX6B1
Pharmacological action	unknown
Actions	Not Available
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.7432
Cytochrome c oxidase polypeptide 7A1, mitochondrial
Name	Cytochrome c oxidase polypeptide 7A1, mitochondrial
Gene Name	COX7A1
Pharmacological action	unknown
Actions	Not Available
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.7433
Phospholipase A2
Name	Phospholipase A2
Gene Name	PLA2G1B
Pharmacological action	unknown
Actions	Not Available
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	1.4478
Liver carboxylesterase 1
Name	Liver carboxylesterase 1
Gene Name	CES1
Pharmacological action	unknown
Actions	Not Available
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.7931
Ferrochelatase
Name	Ferrochelatase
Gene Name	DKFZp686P18130
Pharmacological action	unknown
Actions	Not Available
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.5744
Choloylglycine hydrolase
Name	Choloylglycine hydrolase
Gene Name	cbh
Pharmacological action	unknown
Actions	Not Available
References	Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score	0.8664

Bile salt export pump
Name	Bile salt export pump
Gene Name	ABCB11
Actions	substrate,inhibitor,inducer
References	Hartmann G, Cheung AK, Piquette-Miller M: Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia. J Pharmacol Exp Ther. 2002 Oct;303(1):273-81. - Pubmed Green RM, Hoda F, Ward KL: Molecular cloning and characterization of the murine bile salt export pump. Gene. 2000 Jan 4;241(1):117-23. - Pubmed Mita S, Suzuki H, Akita H, Stieger B, Meier PJ, Hofmann AF, Sugiyama Y: Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump. Am J Physiol Gastrointest Liver Physiol. 2005 Jan;288(1):G159-67. Epub 2004 Aug 5. - Pubmed
DTHybrid score	0.5705
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions	inducer
References	Fickert P, Zollner G, Fuchsbichler A, Stumptner C, Pojer C, Zenz R, Lammert F, Stieger B, Meier PJ, Zatloukal K, Denk H, Trauner M: Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver. Gastroenterology. 2001 Jul;121(1):170-83. - Pubmed
DTHybrid score	0.6919
Multidrug resistance-associated protein 1
Name	Multidrug resistance-associated protein 1
Gene Name	ABCC1
Actions	inducer
References	Hartmann G, Cheung AK, Piquette-Miller M: Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia. J Pharmacol Exp Ther. 2002 Oct;303(1):273-81. - Pubmed
DTHybrid score	0.5156
Solute carrier organic anion transporter family member 1A2
Name	Solute carrier organic anion transporter family member 1A2
Gene Name	SLCO1A2
Actions	substrate,inhibitor,inducer
References	Fickert P, Zollner G, Fuchsbichler A, Stumptner C, Pojer C, Zenz R, Lammert F, Stieger B, Meier PJ, Zatloukal K, Denk H, Trauner M: Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver. Gastroenterology. 2001 Jul;121(1):170-83. - Pubmed Kullak-Ublick GA, Hagenbuch B, Stieger B, Schteingart CD, Hofmann AF, Wolkoff AW, Meier PJ: Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology. 1995 Oct;109(4):1274-82. - Pubmed Kullak-Ublick GA, Hagenbuch B, Stieger B, Wolkoff AW, Meier PJ: Functional characterization of the basolateral rat liver organic anion transporting polypeptide. Hepatology. 1994 Aug;20(2):411-6. - Pubmed Kanai N, Lu R, Bao Y, Wolkoff AW, Schuster VL: Transient expression of oatp organic anion transporter in mammalian cells: identification of candidate substrates. Am J Physiol. 1996 Feb;270(2 Pt 2):F319-25. - Pubmed Hata S, Wang P, Eftychiou N, Ananthanarayanan M, Batta A, Salen G, Pang KS, Wolkoff AW: Substrate specificities of rat oatp1 and ntcp: implications for hepatic organic anion uptake. Am J Physiol Gastrointest Liver Physiol. 2003 Nov;285(5):G829-39. Epub 2003 Jul 3. - Pubmed Jacquemin E, Hagenbuch B, Stieger B, Wolkoff AW, Meier PJ: Expression cloning of a rat liver Na(+)-independent organic anion transporter. Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):133-7. - Pubmed Kouzuki H, Suzuki H, Ito K, Ohashi R, Sugiyama Y: Contribution of organic anion transporting polypeptide to uptake of its possible substrates into rat hepatocytes. J Pharmacol Exp Ther. 1999 Feb;288(2):627-34. - Pubmed Eckhardt U, Schroeder A, Stieger B, Hochli M, Landmann L, Tynes R, Meier PJ, Hagenbuch B: Polyspecific substrate uptake by the hepatic organic anion transporter Oatp1 in stably transfected CHO cells. Am J Physiol. 1999 Apr;276(4 Pt 1):G1037-42. - Pubmed
DTHybrid score	0.7291
Ileal sodium/bile acid cotransporter
Name	Ileal sodium/bile acid cotransporter
Gene Name	SLC10A2
Actions	substrate,inhibitor,inducer
References	Fickert P, Zollner G, Fuchsbichler A, Stumptner C, Pojer C, Zenz R, Lammert F, Stieger B, Meier PJ, Zatloukal K, Denk H, Trauner M: Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver. Gastroenterology. 2001 Jul;121(1):170-83. - Pubmed Craddock AL, Love MW, Daniel RW, Kirby LC, Walters HC, Wong MH, Dawson PA: Expression and transport properties of the human ileal and renal sodium-dependent bile acid transporter. Am J Physiol. 1998 Jan;274(1 Pt 1):G157-69. - Pubmed Saeki T, Matoba K, Furukawa H, Kirifuji K, Kanamoto R, Iwami K: Characterization, cDNA cloning, and functional expression of mouse ileal sodium-dependent bile acid transporter. J Biochem. 1999 Apr;125(4):846-51. - Pubmed Saeki T, Takahashi N, Kanamoto R, Iwami K: Characterization of cloned mouse Na+/taurocholate cotransporting polypeptide by transient expression in COS-7 cells. Biosci Biotechnol Biochem. 2002 May;66(5):1116-8. - Pubmed Walters HC, Craddock AL, Fusegawa H, Willingham MC, Dawson PA: Expression, transport properties, and chromosomal location of organic anion transporter subtype 3. Am J Physiol Gastrointest Liver Physiol. 2000 Dec;279(6):G1188-200. - Pubmed
DTHybrid score	0.643
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions	inducer
References	Fickert P, Zollner G, Fuchsbichler A, Stumptner C, Pojer C, Zenz R, Lammert F, Stieger B, Meier PJ, Zatloukal K, Denk H, Trauner M: Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver. Gastroenterology. 2001 Jul;121(1):170-83. - Pubmed
DTHybrid score	0.624
Solute carrier organic anion transporter family member 1B1
Name	Solute carrier organic anion transporter family member 1B1
Gene Name	SLCO1B1
Actions	substrate,inhibitor,inducer
References	Hartmann G, Cheung AK, Piquette-Miller M: Inflammatory cytokines, but not bile acids, regulate expression of murine hepatic anion transporters in endotoxemia. J Pharmacol Exp Ther. 2002 Oct;303(1):273-81. - Pubmed Konig J, Cui Y, Nies AT, Keppler D: A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. Am J Physiol Gastrointest Liver Physiol. 2000 Jan;278(1):G156-64. - Pubmed Cui Y, Konig J, Leier I, Buchholz U, Keppler D: Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6. J Biol Chem. 2001 Mar 30;276(13):9626-30. Epub 2000 Dec 27. - Pubmed
DTHybrid score	0.6877
Canalicular multispecific organic anion transporter 2
Name	Canalicular multispecific organic anion transporter 2
Gene Name	ABCC3
Actions	inhibitor
References	Hirohashi T, Suzuki H, Takikawa H, Sugiyama Y: ATP-dependent transport of bile salts by rat multidrug resistance-associated protein 3 (Mrp3). J Biol Chem. 2000 Jan 28;275(4):2905-10. - Pubmed
DTHybrid score	0.4424
Multidrug resistance-associated protein 4
Name	Multidrug resistance-associated protein 4
Gene Name	ABCC4
Actions	inhibitor
References	Rius M, Nies AT, Hummel-Eisenbeiss J, Jedlitschky G, Keppler D: Cotransport of reduced glutathione with bile salts by MRP4 (ABCC4) localized to the basolateral hepatocyte membrane. Hepatology. 2003 Aug;38(2):374-84. - Pubmed Bai J, Lai L, Yeo HC, Goh BC, Tan TM: Multidrug resistance protein 4 (MRP4/ABCC4) mediates efflux of bimane-glutathione. Int J Biochem Cell Biol. 2004 Feb;36(2):247-57. - Pubmed
DTHybrid score	0.5071
Sodium/bile acid cotransporter
Name	Sodium/bile acid cotransporter
Gene Name	SLC10A1
Actions	substrate,inhibitor
References	Hagenbuch B, Stieger B, Foguet M, Lubbert H, Meier PJ: Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10629-33. - Pubmed Schroeder A, Eckhardt U, Stieger B, Tynes R, Schteingart CD, Hofmann AF, Meier PJ, Hagenbuch B: Substrate specificity of the rat liver Na(+)-bile salt cotransporter in Xenopus laevis oocytes and in CHO cells. Am J Physiol. 1998 Feb;274(2 Pt 1):G370-5. - Pubmed Hata S, Wang P, Eftychiou N, Ananthanarayanan M, Batta A, Salen G, Pang KS, Wolkoff AW: Substrate specificities of rat oatp1 and ntcp: implications for hepatic organic anion uptake. Am J Physiol Gastrointest Liver Physiol. 2003 Nov;285(5):G829-39. Epub 2003 Jul 3. - Pubmed Mita S, Suzuki H, Akita H, Stieger B, Meier PJ, Hofmann AF, Sugiyama Y: Vectorial transport of bile salts across MDCK cells expressing both rat Na+-taurocholate cotransporting polypeptide and rat bile salt export pump. Am J Physiol Gastrointest Liver Physiol. 2005 Jan;288(1):G159-67. Epub 2004 Aug 5. - Pubmed Platte HD, Honscha W, Schuh K, Petzinger E: Functional characterization of the hepatic sodium-dependent taurocholate transporter stably transfected into an immortalized liver-derived cell line and V79 fibroblasts. Eur J Cell Biol. 1996 May;70(1):54-60. - Pubmed
DTHybrid score	0.5965
Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Actions	inhibitor
References	Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. Mol Pharmacol. 2001 May;59(5):1277-86. - Pubmed Kusuhara H, Sekine T, Utsunomiya-Tate N, Tsuda M, Kojima R, Cha SH, Sugiyama Y, Kanai Y, Endou H: Molecular cloning and characterization of a new multispecific organic anion transporter from rat brain. J Biol Chem. 1999 May 7;274(19):13675-80. - Pubmed
DTHybrid score	0.5769
Solute carrier family 22 member 7
Name	Solute carrier family 22 member 7
Gene Name	SLC22A7
Actions	inhibitor
References	Sekine T, Cha SH, Tsuda M, Apiwattanakul N, Nakajima N, Kanai Y, Endou H: Identification of multispecific organic anion transporter 2 expressed predominantly in the liver. FEBS Lett. 1998 Jun 12;429(2):179-82. - Pubmed
DTHybrid score	0.4267
Solute carrier organic anion transporter family member 1B3
Name	Solute carrier organic anion transporter family member 1B3
Gene Name	SLCO1B3
Actions	substrate
References	Cui Y, Konig J, Leier I, Buchholz U, Keppler D: Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6. J Biol Chem. 2001 Mar 30;276(13):9626-30. Epub 2000 Dec 27. - Pubmed
DTHybrid score	0.6177

Bile salt export pump
Name	Bile salt export pump
Gene Name	ABCB11
Actions
References	Not Available
DTHybrid score	0.5705
Multidrug resistance protein 1
Name	Multidrug resistance protein 1
Gene Name	ABCB1
Actions
References	Not Available
DTHybrid score	0.6919
Multidrug resistance-associated protein 1
Name	Multidrug resistance-associated protein 1
Gene Name	ABCC1
Actions
References	Not Available
DTHybrid score	0.5156
Solute carrier organic anion transporter family member 1A2
Name	Solute carrier organic anion transporter family member 1A2
Gene Name	SLCO1A2
Actions
References	Not Available
DTHybrid score	0.7291
Ileal sodium/bile acid cotransporter
Name	Ileal sodium/bile acid cotransporter
Gene Name	SLC10A2
Actions
References	Not Available
DTHybrid score	0.643
Canalicular multispecific organic anion transporter 1
Name	Canalicular multispecific organic anion transporter 1
Gene Name	ABCC2
Actions
References	Not Available
DTHybrid score	0.624
Solute carrier organic anion transporter family member 1B1
Name	Solute carrier organic anion transporter family member 1B1
Gene Name	SLCO1B1
Actions
References	Not Available
DTHybrid score	0.6877
Canalicular multispecific organic anion transporter 2
Name	Canalicular multispecific organic anion transporter 2
Gene Name	ABCC3
Actions
References	Not Available
DTHybrid score	0.4424
Multidrug resistance-associated protein 4
Name	Multidrug resistance-associated protein 4
Gene Name	ABCC4
Actions
References	Not Available
DTHybrid score	0.5071
Sodium/bile acid cotransporter
Name	Sodium/bile acid cotransporter
Gene Name	SLC10A1
Actions
References	Not Available
DTHybrid score	0.5965
Solute carrier family 22 member 8
Name	Solute carrier family 22 member 8
Gene Name	SLC22A8
Actions
References	Not Available
DTHybrid score	0.5769
Solute carrier family 22 member 7
Name	Solute carrier family 22 member 7
Gene Name	SLC22A7
Actions
References	Not Available
DTHybrid score	0.4267
Solute carrier organic anion transporter family member 1B3
Name	Solute carrier organic anion transporter family member 1B3
Gene Name	SLCO1B3
Actions
References	Not Available
DTHybrid score	0.6177

Id	Partner name	Gene Name	Score
6559	Cytochrome c oxidase subunit 2	ctaC	0.7423
6669	Cytochrome c oxidase subunit 2	ctaC	0.7423
6558	Cytochrome c oxidase subunit 1	ctaD	0.7417
2391	Ferrochelatase	hemH	0.5744
4512	Cytochrome P450 3A4	CYP3A4	0.3593
2529	Alpha-ketoglutarate-dependent taurine dioxygenase	tauD	0.3538
1729	Solute carrier family 22 member 6	SLC22A6	0.3098
6589	Delta-hemolysin	hld	0.2879
6423	Light-harvesting protein B-800/820 alpha chain	Not Available	0.2878
6424	Light-harvesting protein B-800/820 beta chain	Not Available	0.2877
6587	Rubredoxin	rub	0.2875
6586	Protein S100-G	S100G	0.2874
6591	ATP synthase C chain	atpH	0.2874
4718	Putative ATP-dependent Clp protease proteolytic subunit, mitochondrial	CLPP	0.2867
6588	Methionyl-tRNA formyltransferase	fmt	0.2867
6585	HLA class I histocompatibility antigen, B-27 alpha chain	HLA-B	0.2866
6592	Probable L-ascorbate-6-phosphate lactonase ulaG	ulaG	0.2866
6593	Immunoglobulin G-binding protein G	spg	0.2864
1732	ATP-binding cassette sub-family G member 2	ABCG2	0.277
6279	Beta-2-microglobulin	B2M	0.25
6319	Respiratory nitrate reductase 1 gamma chain	narI	0.2497
3175	Glutamate--cysteine ligase	gshA	0.2494
6318	Respiratory nitrate reductase 1 beta chain	narH	0.2494
6317	Respiratory nitrate reductase 1 alpha chain	narG	0.2492
4757	Cytochrome P450 2C9	CYP2C9	0.2491
4924	Cytochrome P450 2C8	CYP2C8	0.2469
6428	Light-harvesting protein B-800/850 beta chain	Not Available	0.2309
6427	Light-harvesting protein B-800/850 alpha chain	Not Available	0.2308
6533	Light-harvesting protein B-800/850 alpha chain	A1	0.2308
6576	Geranylgeranyl transferase type-2 subunit beta	RABGGTB	0.2173
6575	Geranylgeranyl transferase type-2 subunit alpha	RABGGTA	0.2171
4118	Cytochrome P450 3A5	CYP3A5	0.2067
587	Serum albumin	ALB	0.205
2132	Protein S100-B	S100B	0.1922
6352	Reaction center protein H chain	puhA	0.1892
6456	Reaction center protein H chain	puhA	0.1892
6682	Reaction center protein H chain	puhA	0.1892
6353	Reaction center protein L chain	pufL	0.1892
6454	Reaction center protein L chain	pufL	0.1892
6683	Reaction center protein L chain	pufL	0.1892
6354	Reaction center protein M chain	pufM	0.1891
6455	Reaction center protein M chain	pufM	0.1891
6684	Reaction center protein M chain	pufM	0.1891
6351	Photosynthetic reaction center cytochrome c subunit	pufC	0.1891
1024	Solute carrier family 22 member 11	SLC22A11	0.1868
6016	Cytochrome P450 2C19	CYP2C19	0.1776
3027	Streptavidin	Not Available	0.1669
6243	Nuclear receptor-interacting protein 1	NRIP1	0.1619
1632	Solute carrier organic anion transporter family member 2B1	SLCO2B1	0.1604
309	Antithrombin-III	SERPINC1	0.1556
6107	Cytochrome P450 3A7	CYP3A7	0.1512
4200	Cytochrome P450 1A2	CYP1A2	0.1483
4119	Cytochrome P450 2D6	CYP2D6	0.1483
5682	Ribonuclease pancreatic	RNASE1	0.1452
1999	Methylated-DNA--protein-cysteine methyltransferase	MGMT	0.1368
6145	Solute carrier family 22 member 1	SLC22A1	0.1352
6158	Solute carrier organic anion transporter family member 1C1	SLCO1C1	0.1324
1243	Cathepsin D	CTSD	0.1272
559	NADH-ubiquinone oxidoreductase chain 1	MT-ND1	0.122
6030	Cytochrome P450 2B6	CYP2B6	0.1164
6148	Multidrug resistance-associated protein 7	ABCC10	0.1163
6270	Group IIE secretory phospholipase A2	PLA2G2E	0.1132
6013	Cytochrome P450 2E1	CYP2E1	0.1118
6153	Solute carrier organic anion transporter family member 4A1	SLCO4A1	0.107
6155	ATP-binding cassette transporter sub-family C member 11	ABCC11	0.1069
3671	7-alpha-hydroxysteroid dehydrogenase	hdhA	0.1055
6022	UDP-glucuronosyltransferase 1-1	UGT1A1	0.0977
6178	UDP-glucuronosyltransferase 2B7	UGT2B7	0.0953
6136	Multidrug resistance-associated protein 5	ABCC5	0.0952
2616	Ganglioside GM2 activator	GM2A	0.0932
631	3-hydroxy-3-methylglutaryl-coenzyme A reductase	HMGCR	0.092
3387	3-hydroxy-3-methylglutaryl-coenzyme A reductase	mvaA	0.092
738	Monocarboxylate transporter 1	SLC16A1	0.0919
6160	Solute carrier organic anion transporter family member 3A1	SLCO3A1	0.0907
6024	Cytochrome P450 1A1	CYP1A1	0.0907
6557	Lactaldehyde dehydrogenase	aldA	0.0884
6150	Solute carrier organic anion transporter family member 4C1	SLCO4C1	0.0865
6144	Solute carrier family 22 member 2	SLC22A2	0.0855
3307	Acriflavine resistance protein B	acrB	0.0839
1539	Oligopeptide transporter, small intestine isoform	SLC15A1	0.0834
20	Prostaglandin G/H synthase 1	PTGS1	0.0786
290	Prostaglandin G/H synthase 2	PTGS2	0.0785
6167	Organic solute transporter subunit beta	OSTB	0.0777
6166	Organic solute transporter subunit alpha	OSTA	0.0777
118	Organic cation/carnitine transporter 2	SLC22A5	0.0776
4990	PpcA	ppcA	0.0771
2283	Steroid Delta-isomerase	ksi	0.071
2920	Steroid Delta-isomerase	ksi	0.071
6556	Elongation factor Tu GTP-binding domain-containing protein 1	EFTUD1	0.0709
5718	Cytochrome P450 2A6	CYP2A6	0.0704
6018	UDP-glucuronosyltransferase 1-9	UGT1A9	0.0704
6137	Multidrug resistance-associated protein 6	ABCC6	0.0694
136	Estrogen receptor	ESR1	0.0679
1898	Cytochrome P450 1B1	CYP1B1	0.0665
33	Cystine/glutamate transporter	SLC7A11	0.0657
1758	GTPase HRas	HRAS	0.0637
6176	UDP-glucuronosyltransferase 1-3	UGT1A3	0.062
2981	Phospholipase A2, membrane associated	PLA2G2A	0.061
1284	Nuclear receptor subfamily 1 group I member 2	NR1I2	0.0598
396	Alcohol dehydrogenase 4	ADH4	0.0567
686	Aldo-keto reductase family 1 member C2	AKR1C2	0.0561
6147	Solute carrier family 22 member 3	SLC22A3	0.0547
2853	14 kDa fatty acid-binding protein	Not Available	0.0545
1974	Oligopeptide transporter, kidney isoform	SLC15A2	0.0541
338	DNA polymerase	UL30	0.054
379	DNA polymerase	UL54	0.054
697	DNA polymerase	ORF28	0.054
2482	DNA polymerase	43	0.054
4104	DNA polymerase	BALF5	0.054
3811	Cytochrome P450 19A1	CYP19A1	0.0517
251	Alcohol dehydrogenase 1A	ADH1A	0.0516
70	Type-1 angiotensin II receptor	AGTR1	0.051
2211	Fatty acid-binding protein, heart	FABP3	0.0509
444	Alcohol dehydrogenase 1B	ADH1B	0.0499
24	Thymidylate synthase	TMP1	0.0497
359	Thymidylate synthase	TYMS	0.0497
2626	Thymidylate synthase	thyA	0.0497
2729	Thymidylate synthase	thyA	0.0497
5352	Thymidylate synthase	THYA	0.0497
3381	Alcohol dehydrogenase	Not Available	0.049
4508	Alcohol dehydrogenase	adhA	0.049
833	Organic cation/carnitine transporter 1	SLC22A4	0.0485
6677	Myelin P2 protein	PMP2	0.0482
6017	Cholesterol side-chain cleavage enzyme, mitochondrial	CYP11A1	0.0478
817	DNA topoisomerase 2-alpha	TOP2A	0.0474
132	ATP-binding cassette sub-family A member 1	ABCA1	0.0471
1181	Alpha-1-acid glycoprotein 1	ORM1	0.047
238	Peroxisome proliferator-activated receptor gamma	PPARG	0.045
3382	Glycolipid transfer protein	GLTP	0.0449
871	Glucocorticoid receptor	NR3C1	0.0435
373	Transthyretin	TTR	0.0425
758	Thyroid hormone receptor alpha	THRA	0.0415
594	Thyroxine-binding globulin	SERPINA7	0.0404
3947	Xanthine dehydrogenase/oxidase	XDH	0.0399
4615	Chain A, Red Copper Protein Nitrosocyanin	NE0143	0.0389
6149	Solute carrier family 22 member 10	SLC22A10	0.0386
2183	Fatty acid-binding protein, adipocyte	FABP4	0.038
1992	Vitamin D-binding protein	GC	0.0379
197	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial	SDHA	0.0374
346	Thyroid hormone receptor beta-1	THRB	0.0372
244	Angiotensin-converting enzyme	ACE	0.0364
731	HIV-1 protease	HIV-1 protease	0.0363
3312	Fatty acid-binding protein, brain	FABP7	0.0362
805	Cytochrome P450 11B1, mitochondrial	CYP11B1	0.0355
2184	Cystic fibrosis transmembrane conductance regulator	CFTR	0.0352
6606	Platelet-activating factor acetylhydrolase IB subunit gamma	PAFAH1B3	0.0348
4175	Platelet-activating factor acetylhydrolase	PLA2G7	0.0348
2751	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0339
4755	Holliday junction ATP-dependent DNA helicase ruvB	ruvB	0.0339
762	Voltage-dependent calcium channel subunit alpha-2/delta-1	CACNA2D1	0.032
869	Estrogen receptor beta	ESR2	0.0317
5626	Nucleoside diphosphate kinase B	NME2	0.0316
489	Monocarboxylate transporter 2	SLC16A7	0.0314
29	Tubulin beta-1 chain	TUBB1	0.0313
468	Cytochrome P450 4A11	CYP4A11	0.031
6154	Multidrug and toxin extrusion protein 1	SLC47A1	0.031
6020	Aldehyde oxidase	AOX1	0.03
3411	Cytochrome P450 121	cyp121	0.03
806	Sodium/potassium-transporting ATPase alpha-1 chain	ATP1A1	0.0297
4132	Chloride channel protein ClC-Ka	CLCNKA	0.0292
3868	Calcineurin subunit B isoform 2	PPP3R2	0.0285
421	Calcium signal-modulating cyclophilin ligand	CAMLG	0.0285
2222	Equilibrative nucleoside transporter 1	SLC29A1	0.0263
87	Hypoxanthine-guanine phosphoribosyltransferase	HPRT1	0.0262
6152	Solute carrier organic anion transporter family member 2A1	SLCO2A1	0.026
5294	Nucleoside diphosphate kinase A	NME1	0.0256
3917	Methylenetetrahydrofolate reductase	MTHFR	0.0255
904	Glutathione S-transferase P	GSTP1	0.0254
3810	Catechol O-methyltransferase	COMT	0.0252
161	Tubulin beta chain	TUBB	0.0252
312	Tubulin beta chain	TUB2	0.0252
509	Thymidine kinase	TK	0.025
570	Thymidine kinase	TK	0.025
2559	Thymidine kinase	TK	0.025
3430	Thymidine kinase	tdk	0.025
3518	Thymidine kinase	TK	0.025
5301	Thymidine kinase	tdk	0.025
5771	Thymidine kinase	ORF36	0.025
7009	Thymidine kinase	ORF36	0.025
245	Large neutral amino acids transporter small subunit 1	SLC7A5	0.025
273	Apoptosis regulator Bcl-2	BCL2	0.025
1141	Sialidase-1	NEU1	0.0249
64	Neuraminidase	NA	0.0249
641	Neuraminidase	NA	0.0249
2676	Neuraminidase	NA	0.0249
3026	Neuraminidase	NA	0.0249
3519	Neuraminidase	NA	0.0249
6007	Neuraminidase	NA	0.0249
471	Sodium- and chloride-dependent neutral and basic amino acid transporter B(0+)	SLC6A14	0.0247
6031	Cytochrome P450 3A43	CYP3A43	0.0246
6085	Fatty acid-binding protein, intestinal	FABP2	0.0245
2539	Tubulin alpha-1 chain	TUBA4A	0.0242
293	Gamma-glutamyl hydrolase	GGH	0.0241
6106	Cytochrome P450 2C18	CYP2C18	0.024
1650	Heme carrier protein 1	SLC46A1	0.0236
6177	UDP-glucuronosyltransferase 1-10	UGT1A10	0.0233
6181	UDP-glucuronosyltransferase 1-8	UGT1A8	0.0232
1524	Peptidyl-prolyl cis-trans isomerase A	PPIA	0.0226
6700	Peptidyl-prolyl cis-trans isomerase A	ppiA	0.0226
2300	Lysozyme	E	0.0221
3633	Lysozyme	R	0.0221
5597	Lysozyme	17	0.0221
5923	Microtubule-associated protein tau	MAPT	0.0221
5924	Microtubule-associated protein 4	MAP4	0.0221
3923	Cholinesterase	BCHE	0.022
380	Cytochrome P450 17A1	CYP17A1	0.022
1852	Microtubule-associated protein 2	MAP2	0.0219
756	Sex hormone-binding globulin	SHBG	0.0215
723	Cytosolic phospholipase A2	PLA2G4A	0.021
2417	Chloramphenicol acetyltransferase	cat	0.0207
3278	Chloramphenicol acetyltransferase	cat	0.0207
477	DNA topoisomerase 4 subunit A	parC	0.0206
886	DNA topoisomerase 4 subunit A	parC	0.0206
6226	DNA topoisomerase 4 subunit A	parC	0.0206
22	30S ribosomal protein S4	rpsD	0.0206
6714	30S ribosomal protein S4	rpsD	0.0206
199	Monocarboxylate transporter 8	SLC16A2	0.0205
5482	Sialidase-2	NEU2	0.0204
404	DNA gyrase subunit A	gyrA	0.0203
6224	DNA gyrase subunit A	gyrA	0.0203
230	ATP-binding cassette transporter sub-family C member 8	ABCC8	0.0202
737	Mineralocorticoid receptor	NR3C2	0.0199
6151	Monocarboxylate transporter 10	SLC16A10	0.0196
6025	UDP-glucuronosyltransferase 1-4	UGT1A4	0.0196
6040	6-phosphogluconate dehydrogenase, decarboxylating	PGD	0.0196
614	Progesterone receptor	PGR	0.0196
6339	Ig kappa chain V-II region RPMI 6410	Not Available	0.0196
698	B-Raf proto-oncogene serine/threonine-protein kinase	BRAF	0.0194
140	30S ribosomal protein S9	rpsI	0.0194
6719	30S ribosomal protein S9	rpsI	0.0194
6725	30S ribosomal protein S9	rpsI	0.0194
6042	Prostaglandin reductase 2	PTGR2	0.0192
492	Histamine H1 receptor	HRH1	0.0191
198	Sodium channel protein type 10 subunit alpha	SCN10A	0.0191
952	Dipeptidyl peptidase 4	DPP4	0.019
275	Arachidonate 5-lipoxygenase	ALOX5	0.0189
2230	Catalase	CAT	0.0188
3249	Catalase	katA	0.0188
3625	Catalase	katA	0.0188
4539	Catalase	katA	0.0188
4941	Catalase	katB	0.0188
2404	Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform	PIK3CG	0.0186
683	Potassium transporter	GK0582	0.0185
1313	Lactoylglutathione lyase	GLO1	0.0182
3270	Elongation factor G	fusA	0.0181
1302	Dihydropyrimidine dehydrogenase [NADP+]	DPYD	0.018
101	Potassium voltage-gated channel subfamily H member 2	KCNH2	0.018
6218	Pannexin-1	PANX1	0.0179
663	Solute carrier family 12 member 4	SLC12A4	0.0178
53	Solute carrier family 12 member 5	SLC12A5	0.0178
40	RAF proto-oncogene serine/threonine-protein kinase	RAF1	0.0178
3639	Thymidine phosphorylase	deoA	0.0177
3936	Thymidine phosphorylase	TYMP	0.0177
146	Androgen receptor	AR	0.0176
6043	Putative G-protein coupled receptor 44	GPR44	0.0174
2808	Chloramphenicol acetyltransferase 3	cat3	0.0174
6168	Solute carrier family 22 member 16	SLC22A16	0.0171
558	Solute carrier family 12 member 1	SLC12A1	0.0169
310	Solute carrier family 12 member 2	SLC12A2	0.0166
26	Vascular endothelial growth factor receptor 3	FLT4	0.0165
908	Glutathione S-transferase theta-1	GSTT1	0.0163
6033	High affinity interleukin-8 receptor A	CXCR1	0.0163
887	DNA gyrase subunit B	gyrB	0.0162
4150	DNA gyrase subunit B	gyrB	0.0162
6225	DNA gyrase subunit B	gyrB	0.0162
3685	Catabolite gene activator	crp	0.0162
4655	Adenylate cyclase	cyaC	0.0162
4759	Adenylate cyclase	cyaB2	0.0162
6023	Cytochrome P450 11B2, mitochondrial	CYP11B2	0.0161
781	ATP-sensitive inward rectifier potassium channel 11	KCNJ11	0.0161
159	Penicillin-binding protein 2B	penA	0.016
6121	Penicillin-binding protein 2B	penA	0.016
5818	Folate receptor alpha	FOLR1	0.016
13	Aminomethyltransferase, mitochondrial	AMT	0.016
124	Histamine H2 receptor	HRH2	0.0159
32	Vascular endothelial growth factor receptor 1	FLT1	0.0158
3970	Voltage-dependent N-type calcium channel subunit alpha-1B	CACNA1B	0.0155
4238	50S ribosomal protein L4	rplD	0.0153
5578	50S ribosomal protein L4	rplD	0.0153
6173	50S ribosomal protein L4	rplD	0.0153
6219	50S ribosomal protein L4	rplD	0.0153
521	ATP-binding cassette transporter sub-family C member 9	ABCC9	0.0152
6180	UDP-glucuronosyltransferase 2B4	UGT2B4	0.0151
407	Vascular endothelial growth factor receptor 2	KDR	0.015
2261	Major NAD(P)H-flavin oxidoreductase	Not Available	0.0149
6221	Steroid hormone receptor ERR1	ESRRA	0.0147
4120	NADPH--cytochrome P450 reductase	POR	0.0146
6104	Dimethylaniline monooxygenase [N-oxide-forming] 1	FMO1	0.0145
232	Corticosteroid-binding globulin	SERPINA6	0.0145
3961	G protein-activated inward rectifier potassium channel 4	KCNJ5	0.0145
1457	Long-chain-fatty-acid--CoA ligase 4	ACSL4	0.0143
406	Prostaglandin E2 receptor, EP2 subtype	PTGER2	0.0143
220	Sodium channel protein type 5 subunit alpha	SCN5A	0.0142
6599	HTH-type transcriptional regulator ttgR	ttgR	0.0142
267	Plasminogen activator inhibitor 1	SERPINE1	0.0141
5353	Glutamate decarboxylase alpha	gadA	0.0141
4237	50S ribosomal protein L22	rplV	0.0141
504	Mast/stem cell growth factor receptor	KIT	0.0141
1353	DNA topoisomerase 1	TOP1	0.014
3552	DNA topoisomerase 1	topA	0.014
6206	DNA-directed RNA polymerase subunit beta'	rpoC	0.014
543	Penicillin-binding protein 1B	mrcB	0.0139
6186	Penicillin-binding protein 1B	ponB	0.0139
6822	Penicillin-binding protein 1b	pbp1b	0.0139
6844	Penicillin-binding protein 1b	pbp1b	0.0139
890	Niemann-Pick C1-like protein 1	NPC1L1	0.0139
4760	Mll3241 protein	mll3241	0.0138
4122	Histone deacetylase 2	HDAC2	0.0138
645	Penicillin-binding protein 1A	mrcA	0.0137
5805	Penicillin-binding protein 1A	ponA	0.0137
6185	Penicillin-binding protein 1A	mrcA	0.0137
6799	Penicillin-binding protein 1A	pbpA	0.0137
2178	Metabotropic glutamate receptor 5	GRM5	0.0136
824	Sodium-dependent serotonin transporter	SLC6A4	0.0135
4773	Deoxycytidine kinase	DCK	0.0134
1757	Myeloperoxidase	MPO	0.0132
4192	DNA topoisomerase 2-beta	TOP2B	0.0131
5849	cAMP-dependent protein kinase type I-alpha regulatory subunit	PRKAR1A	0.013
6101	Dimethylaniline monooxygenase [N-oxide-forming] 3	FMO3	0.013
102	DNA topoisomerase I, mitochondrial	TOP1MT	0.013
284	DNA-directed RNA polymerase beta chain	rpoB	0.013
5773	DNA-directed RNA polymerase beta chain	rpoB	0.013
243	Ribosyldihydronicotinamide dehydrogenase [quinone]	NQO2	0.0129
3941	Amine oxidase [flavin-containing] A	MAOA	0.0129
1971	cAMP-specific 3',5'-cyclic phosphodiesterase 4A	PDE4A	0.0129
73	Prostaglandin E2 receptor, EP1 subtype	PTGER1	0.0125
1405	Thiopurine S-methyltransferase	TPMT	0.0124
556	Alpha-1A adrenergic receptor	ADRA1A	0.0124
1760	Aminopeptidase N	ANPEP	0.0123
6843	Aminopeptidase N	pepN	0.0123
773	Folylpolyglutamate synthase, mitochondrial	FPGS	0.0122
2287	Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase	ATIC	0.0122
117	Sterol O-acyltransferase 1	SOAT1	0.012
796	Inosine-5'-monophosphate dehydrogenase 2	IMPDH2	0.012
4110	Voltage-dependent L-type calcium channel subunit beta-2	CACNB2	0.0119
4094	Gamma-aminobutyric acid type B receptor, subunit 2	GABBR2	0.0119
4115	Voltage-dependent L-type calcium channel subunit alpha-1D	CACNA1D	0.0119
165	FL cytokine receptor	FLT3	0.0118
677	Choline-phosphate cytidylyltransferase A	PCYT1A	0.0118
2331	HTH-type transcriptional regulator qacR	qacR	0.0118
6461	HTH-type transcriptional regulator qacR	qacR	0.0118
1995	Sodium channel protein type 9 subunit alpha	SCN9A	0.0118
709	ATP-sensitive inward rectifier potassium channel 1	KCNJ1	0.0117
228	Beta platelet-derived growth factor receptor	PDGFRB	0.0117
299	Folate receptor beta	FOLR2	0.0117
718	Folate receptor gamma	FOLR3	0.0117
804	Mitochondrial folate transporter/carrier	SLC25A32	0.0116
478	Voltage-dependent L-type calcium channel subunit alpha-1C	CACNA1C	0.0116
4111	Voltage-dependent L-type calcium channel subunit alpha-1S	CACNA1S	0.0115
3611	Cytidine deaminase	cdd	0.0115
3707	Cytidine deaminase	cdd	0.0115
4211	Cytidine deaminase	CDA	0.0115
1629	Transcription factor AP-1	JUN	0.0115
4857	Zinc-alpha-2-glycoprotein	AZGP1	0.0115
2016	Dipeptidase 1	DPEP1	0.0115
702	UMP-CMP kinase	CMPK1	0.0115
1192	Sulfotransferase 1A1	SULT1A1	0.0114
950	Alpha platelet-derived growth factor receptor	PDGFRA	0.0114
342	P protein [Includes: DNA-directed DNA polymerase	P	0.0114
612	P protein [Includes: DNA-directed DNA polymerase	P	0.0114
139	Aldo-keto reductase family 1 member C1	AKR1C1	0.0114
49	Endothelin B receptor	EDNRB	0.0113
109	Mitochondrial carnitine/acylcarnitine carrier protein CACL	SLC25A29	0.0113
636	Mitochondrial carnitine/acylcarnitine carrier protein	SLC25A20	0.0113
1435	Synaptic vesicle glycoprotein 2A	SV2A	0.0112
320	5-hydroxytryptamine 1A receptor	HTR1A	0.0112
260	Cytochrome P450 51	ERG11	0.0111
761	Cytochrome P450 51	ERG11	0.0111
3163	Cytochrome P450 51	cyp51	0.0111
838	Inosine-5'-monophosphate dehydrogenase 1	IMPDH1	0.0111
6210	Tubulin delta chain	TUBD1	0.0109
6212	Tubulin gamma-1 chain	TUBG1	0.0109
6211	Tubulin epsilon chain	TUBE1	0.0109
4226	Uridine phosphorylase 2	UPP2	0.0108
2449	Tubulin alpha-3 chain	TUBA1A	0.0108
2443	Azurin	azu	0.0108
1867	Major prion protein	PRNP	0.0108
2157	NAD(P)H dehydrogenase [quinone] 1	NQO1	0.0108
3688	Branched-chain-amino-acid aminotransferase	ilvE	0.0107
204	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE5A	0.0107
578	Endothelin-1 receptor	EDNRA	0.0106
831	D(2) dopamine receptor	DRD2	0.0104
412	Peroxisomal carnitine O-octanoyltransferase	CROT	0.0103
551	Carnitine O-acetyltransferase	CRAT	0.0103
365	Dihydrofolate reductase	DHFR	0.0101
2381	Dihydrofolate reductase	DFR1	0.0101
2833	Dihydrofolate reductase	Not Available	0.0101
2931	Dihydrofolate reductase	folA	0.0101
3544	Dihydrofolate reductase	folA	0.0101
3682	Dihydrofolate reductase	folA	0.0101
6642	Dihydrofolate reductase	folA	0.0101
6756	Dihydrofolate reductase	dfrA	0.0101
385	Potassium-transporting ATPase alpha chain 1	ATP4A	0.0101
6220	Aryl hydrocarbon receptor	AHR	0.0101
122	P2Y purinoceptor 12	P2RY12	0.01
131	Synaptic vesicular amine transporter	SLC18A2	0.0099
4225	Uridine phosphorylase 1	UPP1	0.0098
200	Carnitine O-palmitoyltransferase 2, mitochondrial	CPT2	0.0098
451	Carnitine O-palmitoyltransferase I, liver isoform	CPT1A	0.0098
183	Vascular endothelial growth factor A	VEGFA	0.0097
185	Vasopressin V1a receptor	AVPR1A	0.0096
6058	Geranylgeranyl pyrophosphate synthetase	GGPS1	0.0095
322	Vasopressin V2 receptor	AVPR2	0.0093
413	Amidophosphoribosyltransferase	PPAT	0.0093
2515	Amidophosphoribosyltransferase	purF	0.0093
3714	Amidophosphoribosyltransferase	purF	0.0093
240	Gamma-aminobutyric acid type B receptor, subunit 1	GABBR1	0.0093
6207	30S ribosomal protein S14	rpsN	0.0093
6209	30S ribosomal protein S19	rpsS	0.0093
6712	30S ribosomal protein S19	rpsS	0.0093
6726	30S ribosomal protein S19	rpsS	0.0093
1178	Adenosine A2a receptor	ADORA2A	0.0093
193	Beta-1 adrenergic receptor	ADRB1	0.0093
461	Glycine receptor subunit alpha-3	GLRA3	0.0093
115	Penicillin-binding protein 2	mrdA	0.0092
6069	Penicillin-binding protein 2	mrdA	0.0092
6118	Penicillin-binding protein 2	penA	0.0092
6187	Penicillin-binding protein 2	pbpA	0.0092
6686	Penicillin-binding protein 2	pbp2	0.0092
6939	Penicillin-binding protein 2	mrdA	0.0092
7163	Penicillin-binding protein 2	pbpA	0.0092
853	Farnesyl pyrophosphate synthetase	FDPS	0.0092
4217	Telomerase reverse transcriptase	TERT	0.0092
588	Chromodomain-helicase-DNA-binding protein 1	CHD1	0.0091
896	Glutathione S-transferase Mu 1	GSTM1	0.0091
540	Sodium-dependent noradrenaline transporter	SLC6A2	0.009
933	Proto-oncogene tyrosine-protein kinase Src	SRC	0.0087
2249	Aspartate aminotransferase	aspC	0.0087
2671	Aspartate aminotransferase	aspC	0.0087
5490	Aspartate aminotransferase	Not Available	0.0087
617	Muscarinic acetylcholine receptor M2	CHRM2	0.0087
6172	ATP-binding cassette sub-family B member 8, mitochondrial	ABCB8	0.0087
392	Voltage-dependent P/Q-type calcium channel subunit alpha-1A	CACNA1A	0.0087
725	5-hydroxytryptamine 1D receptor	HTR1D	0.0086
1	Peptidoglycan synthetase ftsI	ftsI	0.0086
4155	Peptidoglycan synthetase ftsI	ftsI	0.0086
2021	Thrombomodulin	THBD	0.0086
885	5-hydroxytryptamine 1B receptor	HTR1B	0.0086
813	Neuronal acetylcholine receptor subunit alpha-2	CHRNA2	0.0085
16	Adenosine A1 receptor	ADORA1	0.0085
465	Calmodulin	CALM1	0.0085
6002	Prostaglandin E2 receptor EP4 subtype	PTGER4	0.0084
80	Peroxisome proliferator-activated receptor alpha	PPARA	0.0084
6861	Alcohol dehydrogenase [NADP+]	AKR1A1	0.0083
469	Annexin A1	ANXA1	0.0083
872	Gamma-aminobutyric-acid receptor subunit alpha-1	GABRA1	0.0082
511	5-hydroxytryptamine 1F receptor	HTR1F	0.0082
751	Potassium channel subfamily K member 6	KCNK6	0.0082
502	5-hydroxytryptamine 2A receptor	HTR2A	0.0082
844	Epidermal growth factor receptor	EGFR	0.0082
4114	Voltage-dependent L-type calcium channel subunit beta-3	CACNB3	0.0081
4112	Voltage-dependent L-type calcium channel subunit beta-4	CACNB4	0.0081
850	Vasopressin V1b receptor	AVPR1B	0.0081
5880	Thrombopoietin receptor	MPL	0.0081
6014	Cytochrome P450 2A13	CYP2A13	0.008
527	Prostacyclin receptor	PTGIR	0.0079
54	Prothrombin	F2	0.0079
818	50S ribosomal protein L10	rplJ	0.0079
337	NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial	NDUFS7	0.0079
214	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial	NDUFS3	0.0079
803	NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial	NDUFS2	0.0079
6171	Solute carrier family 28 member 3	SLC28A3	0.0079
4131	Prostaglandin E2 receptor, EP3 subtype	PTGER3	0.0078
4099	Gamma-aminobutyric-acid receptor subunit beta-3	GABRB3	0.0078
672	Prostaglandin F2-alpha receptor	PTGFR	0.0077
632	Alpha-1B adrenergic receptor	ADRA1B	0.0076
7	Nitric oxide synthase, inducible	NOS2	0.0076
1198	Serum paraoxonase/arylesterase 1	PON1	0.0076
6223	Penicillin-binding protein 1C	pbpC	0.0076
462	Intermediate conductance calcium-activated potassium channel protein 4	KCNN4	0.0076
172	Potassium channel subfamily K member 1	KCNK1	0.0076
4113	Voltage-dependent L-type calcium channel subunit alpha-1F	CACNA1F	0.0075
6165	Copper-transporting ATPase 1	ATP7A	0.0075
6163	Copper-transporting ATPase 2	ATP7B	0.0075
1630	Integrin beta-2	ITGB2	0.0075
76	Nitric-oxide synthase, brain	NOS1	0.0075
3957	Adenosine deaminase	ADA	0.0075
485	cGMP-inhibited 3',5'-cyclic phosphodiesterase A	PDE3A	0.0074
333	Voltage-dependent L-type calcium channel subunit beta-1	CACNB1	0.0074
867	Penicillin-binding protein 3	pbpC	0.0073
6119	Penicillin-binding protein 3	pbp3	0.0073
7154	Penicillin-binding protein 3	pbp3	0.0073
7157	Penicillin-binding protein 3	LMHCC_2184	0.0073
7162	Penicillin-binding protein 3	pbpB	0.0073
7172	Penicillin-binding protein 3	pbp3	0.0073
103	Muscarinic acetylcholine receptor M1	CHRM1	0.0072
1648	Elastin	ELN	0.0072
6146	High affinity copper uptake protein 1	SLC31A1	0.0072
1654	Interleukin-1 beta	IL1B	0.0072
5414	Fiber protein	L5	0.0071
5418	Fiber protein	L5	0.0071
4476	Mannitol dehydrogenase	mtlD	0.0071
567	Receptor tyrosine-protein kinase erbB-2	ERBB2	0.0071
1756	E-selectin	SELE	0.0071
438	Taste receptor type 1 member 2	TAS1R2	0.0071
2320	Thymidine kinase, cytosolic	TK1	0.0071
766	Beta-2 adrenergic receptor	ADRB2	0.007
15	Voltage-dependent T-type calcium channel subunit alpha-1I	CACNA1I	0.007
5787	Angiopoietin-1 receptor	TEK	0.007
4152	Superoxide dismutase [Cu-Zn]	SOD1	0.007
633	Penicillin-binding proteins 1A/1B	pbpA	0.0069
695	cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A	PDE10A	0.0068
2298	Cytochrome P450-cam	camC	0.0068
17	Proto-oncogene tyrosine-protein kinase ABL1	ABL1	0.0067
3856	Fibroblast growth factor receptor 3	FGFR3	0.0067
535	Voltage-dependent T-type calcium channel subunit alpha-1G	CACNA1G	0.0067
23	D(1A) dopamine receptor	DRD1	0.0066
847	Mu-type opioid receptor	OPRM1	0.0066
6161	Probable low affinity copper uptake protein 2	SLC31A2	0.0066
3686	Acyl-CoA thioesterase I precursor	tesA	0.0065
4177	Proto-oncogene tyrosine-protein kinase receptor ret	RET	0.0065
5251	Carbonyl reductase [NADPH] 1	CBR1	0.0065
6138	Multidrug resistance protein 3	ABCB4	0.0065
3432	Multidrug-efflux transporter 1 regulator	bmrR	0.0063
650	Aldo-keto reductase family 1 member C3	AKR1C3	0.0062
467	Delta-type opioid receptor	OPRD1	0.0062
706	Glutamate [NMDA] receptor subunit 3A	GRIN3A	0.0062
3629	Endo-N-acetylneuraminidase	Not Available	0.0062
5416	Coat protein VP1	Not Available	0.0061
1130	Lithostathine 1 alpha	REG1A	0.0061
964	Voltage-dependent T-type calcium channel subunit alpha-1H	CACNA1H	0.0061
6044	Serum paraoxonase/lactonase 3	PON3	0.0061
3854	Basic fibroblast growth factor receptor 1	FGFR1	0.0061
1792	Tissue-type plasminogen activator	PLAT	0.0059
4148	Serine/threonine-protein kinase mTOR	MTOR	0.0059
696	Kappa-type opioid receptor	OPRK1	0.0059
494	Caspase-1	CASP1	0.0058
65	Matrix metalloproteinase-9	Not Available	0.0057
951	Macrophage colony-stimulating factor 1 receptor	CSF1R	0.0057
2324	Botulinum neurotoxin type B	botB	0.0057
3547	Enterotoxin type B	entB	0.0057
2058	P-selectin	SELP	0.0056
572	Integrin alpha-L	ITGAL	0.0056
777	Tumor necrosis factor	TNF	0.0056
4878	Glycoprotein hormones alpha chain	CGA	0.0055
4877	Beta-mannanase	man	0.0055
1052	Cytotoxic T-lymphocyte protein 4	CTLA4	0.0055
4850	Beta-2-glycoprotein 1	APOH	0.0055
1507	Cytochrome c	CYCS	0.0055
1072	Granzyme B	GZMB	0.0055
4880	Membrane cofactor protein	CD46	0.0055
4889	Ig epsilon chain C region	IGHE	0.0055
4869	Major capsid protein	A430L	0.0055
4852	Reticulon-4 receptor	RTN4R	0.0055
4189	Alpha-galactosidase A	GLA	0.0055
4871	Endo-beta-N-acetylglucosaminidase F3	endOF3	0.0055
757	Fusion glycoprotein F0	F	0.0055
4875	Fusion glycoprotein F0	F	0.0055
4856	CD209 antigen	CD209	0.0055
1563	Platelet glycoprotein Ib alpha chain	GP1BA	0.0055
442	Envelope glycoprotein	gp41	0.0055
4859	Envelope glycoprotein	env	0.0055
4721	Beta-1,4-mannanase	manA	0.0055
4845	ADAM 33	ADAM33	0.0055
1558	Transient receptor potential cation channel subfamily V member 1	TRPV1	0.0055
1354	Beta-glucuronidase	GUSB	0.0055
4882	Dipeptidyl aminopeptidase-like protein 6	DPP6	0.0055
3352	Structural polyprotein	Not Available	0.0055
3628	Structural polyprotein	Not Available	0.0055
4892	Structural polyprotein	Not Available	0.0055
841	Gamma-aminobutyric-acid receptor subunit alpha-6	GABRA6	0.0053
530	Gamma-aminobutyric-acid receptor subunit alpha-4	GABRA4	0.0053
6182	Cytochrome P450 2J2	CYP2J2	0.0052
3760	Penicillin-binding protein 5 precursor	dacA	0.0052
6836	3-hydroxyisobutyryl-CoA hydrolase, mitochondrial	HIBCH	0.0052
6837	Serine/threonine-protein kinase 17B	STK17B	0.0052
476	RAC-alpha serine/threonine-protein kinase	AKT1	0.0052
580	Gamma-aminobutyric-acid receptor subunit alpha-3	GABRA3	0.0051
523	Gamma-aminobutyric-acid receptor subunit alpha-5	GABRA5	0.0051
341	5-hydroxytryptamine 3 receptor	HTR3A	0.0051
423	Gamma-aminobutyric-acid receptor subunit alpha-2	GABRA2	0.0051
364	Corticosteroid 11-beta-dehydrogenase isozyme 1	HSD11B1	0.0051
2038	Inhibitor of nuclear factor kappa-B kinase subunit beta	IKBKB	0.0051
1010	Cytochrome P450 51A1	CYP51A1	0.0051
274	Muscarinic acetylcholine receptor M5	CHRM5	0.0051
2599	Tyrosine-protein kinase HCK	HCK	0.005
789	Alpha-1D adrenergic receptor	ADRA1D	0.005
889	3-oxoacyl-[acyl-carrier-protein] synthase 1	fabB	0.005
6860	3-oxoacyl-[acyl-carrier-protein] synthase 1	kasA	0.005
1517	Beta-3 adrenergic receptor	ADRB3	0.005
84	Nuclear receptor 0B1	NR0B1	0.0049
450	Muscarinic acetylcholine receptor M4	CHRM4	0.0049
2570	Tetanus toxin	tetX	0.0049
6184	D-alanyl-D-alanine carboxypeptidase dacC	dacC	0.0049
51	Muscarinic acetylcholine receptor M3	CHRM3	0.0049
820	Glycine receptor subunit alpha-2	GLRA2	0.0049
2077	Caspase-3	CASP3	0.0048
6858	Inactive carboxylesterase 4	CES1P1	0.0048
793	T-cell surface antigen CD2	CD2	0.0048
4861	Interleukin-6 receptor alpha chain	IL6R	0.0048
4193	Atrial natriuretic peptide clearance receptor	NPR3	0.0048
3837	Cytokine receptor common beta chain	CSF2RB	0.0048
119	Carcinoembryonic antigen-related cell adhesion molecule 1	CEACAM1	0.0048
819	Penicillin-binding protein 4	dacB	0.0046
1379	Interleukin-12 subunit beta	IL12B	0.0046
4890	Hemagglutinin	HA	0.0046
6566	Hemagglutinin	Not Available	0.0046
4034	Glutaredoxin-1	GLRX	0.0046
1928	Leukotriene C4 synthase	LTC4S	0.0046
4043	Glutaredoxin-2, mitochondrial	GLRX2	0.0046
4037	Hypothetical protein	GPX1	0.0046
4297	Hypothetical protein	SP_1951	0.0046
4521	Hypothetical protein	BC_2969	0.0046
4540	Hypothetical protein	TM_1070	0.0046
4555	Hypothetical protein	MT1739	0.0046
4569	Hypothetical protein	mshD	0.0046
4578	Hypothetical protein	PA3270	0.0046
4747	Hypothetical protein	PA3967	0.0046
5177	Hypothetical protein	TM_0096	0.0046
5194	Hypothetical protein	PA1204	0.0046
5240	Hypothetical protein	Rv2991	0.0046
5370	Hypothetical protein	TM_1158	0.0046
5710	Hypothetical protein	Tb927.5.1360	0.0046
4029	Microsomal glutathione S-transferase 3	MGST3	0.0046
4030	Thioredoxin domain-containing protein 12	TXNDC12	0.0046
907	Glutathione peroxidase 2	GPX2	0.0046
4032	Microsomal glutathione S-transferase 1	MGST1	0.0046
910	Epididymal secretory glutathione peroxidase	GPX5	0.0046
4036	Glutathione peroxidase 6	GPX6	0.0046
903	Glutathione S-transferase A5	GSTA5	0.0046
4039	CDNA FLJ23636 fis, clone CAS07176	GPX8	0.0046
4040	Glutathione peroxidase 7	GPX7	0.0046
911	Glutathione peroxidase 3	GPX3	0.0046
906	Glutathione peroxidase 1	GPX1	0.0046
900	Glutathione S-transferase A4	GSTA4	0.0046
4035	Glutathione S-transferase Mu 5	GSTM5	0.0046
4033	S-formylglutathione hydrolase	ESD	0.0046
4042	Glutathione transferase omega-2	GSTO2	0.0046
4038	Glutathione peroxidase 4	GPX4	0.0046
1975	Phospholipid hydroperoxide glutathione peroxidase, mitochondrial	GPX4	0.0046
1056	Gamma-glutamyltranspeptidase 1	GGT1	0.0046
1184	Interferon beta	IFNB1	0.0046
332	Beta-lactamase	blaZ	0.0046
2478	Beta-lactamase	ampC	0.0046
2613	Beta-lactamase	ampC	0.0046
2635	Beta-lactamase	ampC	0.0046
2700	Beta-lactamase	penP	0.0046
5445	Beta-lactamase	blaB	0.0046
6019	Beta-lactamase	SHV-7	0.0046
6701	Beta-lactamase	cphA	0.0046
1050	Bile salt sulfotransferase	SULT2A1	0.0046
768	FK506-binding protein 1A	FKBP1A	0.0046
2180	3-phosphoinositide-dependent protein kinase 1	PDPK1	0.0046
389	Amiloride-sensitive cation channel 2, neuronal	ACCN2	0.0046
318	Alpha-2A adrenergic receptor	ADRA2A	0.0045
6656	UDP-glucuronosyltransferase 3A1	UGT3A1	0.0045
291	Nitric-oxide synthase, endothelial	NOS3	0.0045
4162	Potassium voltage-gated channel subfamily KQT member 3	KCNQ3	0.0044
482	Glycine receptor subunit alpha-1	GLRA1	0.0044
1086	Potassium voltage-gated channel subfamily KQT member 2	KCNQ2	0.0044
2998	Sialic acid-binding Ig-like lectin 7	SIGLEC7	0.0043
6120	Cation-independent mannose-6-phosphate receptor	IGF2R	0.0043
5934	Cytochrome P450 26A1	CYP26A1	0.0043
2461	D-alanyl-D-alanine carboxypeptidase	Not Available	0.0042
5756	D-alanyl-D-alanine carboxypeptidase	dac	0.0042
3319	Hydroxyacylglutathione hydrolase	HAGH	0.0042
6824	Tyrosine-protein kinase Lyn	LYN	0.0042
992	Protein tyrosine kinase 2 beta	PTK2B	0.0042
3444	Cyanovirin-N	Not Available	0.0042
1859	Prostatic acid phosphatase	ACPP	0.0042
3140	Hemagglutinin-neuraminidase	HN	0.0042
3609	Hemagglutinin-neuraminidase	HN	0.0042
1525	Heparin-binding growth factor 2	FGF2	0.0042
3258	Mannosyl-oligosaccharide alpha-1,2-mannosidase	MSDC	0.0042
898	Glutathione S-transferase A3	GSTA3	0.0042
897	Glutathione S-transferase kappa 1	GSTK1	0.0042
170	Succinate semialdehyde dehydrogenase, mitochondrial	ALDH5A1	0.0042
2723	Cholera enterotoxin subunit B	ctxB	0.0042
1291	cAMP response element-binding protein	CREB1	0.0041
909	Maleylacetoacetate isomerase	GSTZ1	0.0041
714	Glutathione reductase, mitochondrial	GSR	0.0041
4095	Neuronal acetylcholine receptor subunit alpha-7	CHRNA7	0.0041
947	Neuronal acetylcholine receptor subunit alpha-4	CHRNA4	0.0041
918	Glutamate receptor, ionotropic kainate 2	GRIK2	0.0041
2216	Fibroblast growth factor receptor 4	FGFR4	0.0041
4210	Toll-like receptor 4	TLR4	0.0041
905	Glutathione transferase omega-1	GSTO1	0.004
899	Glutathione S-transferase Mu 3	GSTM3	0.004
3804	Sodium channel protein type 4 subunit alpha	SCN4A	0.004
4787	Envelope glycoprotein gp160	env	0.004
4820	Envelope glycoprotein gp160	env	0.004
5727	Envelope glycoprotein gp160	env	0.004
436	5-hydroxytryptamine 2B receptor	HTR2B	0.004
3932	Glutathione S-transferase A2	GSTA2	0.004
1502	Peroxisome proliferator-activated receptor delta	PPARD	0.004
4041	Microsomal glutathione S-transferase 2	MGST2	0.004
4666	Fucose-binding lectin PA-IIL	lecB	0.004
2372	Bifunctional tail protein	9	0.004
474	Acetylcholinesterase	ACHE	0.004
18	High affinity immunoglobulin epsilon receptor subunit alpha	FCER1A	0.0039
554	Low-density lipoprotein receptor	LDLR	0.0039
852	Heparin cofactor 2	SERPIND1	0.0039
2450	Tyrosine-protein kinase ITK/TSK	ITK	0.0039
563	Thyroid peroxidase	TPO	0.0038
858	Potassium voltage-gated channel subfamily A member 1	KCNA1	0.0038
921	Glutamate receptor 2	GRIA2	0.0038
2577	Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase	MAN1B1	0.0038
2232	Interleukin-5	IL5	0.0037
1593	Mucin-2	MUC2	0.0037
2165	Glutathione S-transferase Mu 2	GSTM2	0.0037
182	2-oxoglutarate dehydrogenase E1 component, mitochondrial	OGDH	0.0037
6344	ATP synthase subunit gamma, mitochondrial	ATP5C1	0.0037
6343	ATP synthase subunit beta, mitochondrial	ATP5B	0.0037
6342	ATP synthase subunit alpha, mitochondrial	ATP5A1	0.0037
2472	Voltage-gated potassium channel	kcsA	0.0037
6366	Voltage-gated potassium channel	kcsA	0.0037
3480	Mannan endo-1,4-beta-mannosidase	manA	0.0037
207	Glutathione synthetase	GSS	0.0036
5269	Glutathione synthetase	gshB	0.0036
6038	Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6H	0.0036
595	Fibrinogen alpha chain	FGA	0.0036
1039	Histone deacetylase 9	HDAC9	0.0036
1787	Nuclear factor NF-kappa-B p105 subunit	NFKB1	0.0036
1569	G1/S-specific cyclin-D1	CCND1	0.0036
130	Prostacyclin synthase	PTGIS	0.0036
4097	Neuronal acetylcholine receptor subunit alpha-9	CHRNA9	0.0035
340	Apoptotic protease-activating factor 1	APAF1	0.0035
259	Microsomal triglyceride transfer protein large subunit	MTTP	0.0035
1439	Lactotransferrin	LTF	0.0035
901	Glutathione S-transferase Mu 4	GSTM4	0.0035
958	Insulin-like growth factor 1 receptor	IGF1R	0.0035
2101	Glutathione-requiring prostaglandin D synthase	HPGDS	0.0034
2207	Rhodopsin	RHO	0.0034
6037	Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma	PDE6G	0.0034
1782	Neutrophil gelatinase-associated lipocalin	LCN2	0.0034
2430	Chondroitinase B	cslB	0.0033
2347	Proto-oncogene serine/threonine-protein kinase Pim-1	PIM1	0.0033
937	Proto-oncogene tyrosine-protein kinase LCK	LCK	0.0033
6259	(3R)-hydroxymyristoyl-acyl carrier protein dehydratase	fabZ	0.0033
6307	Ig gamma-2 chain C region	IGHG2	0.0033
2581	Chondroitinase AC	cslA	0.0033
823	Fibroblast growth factor receptor 2	FGFR2	0.0032
3939	Amine oxidase [flavin-containing] B	MAOB	0.0032
6847	Lactase-phlorizin hydrolase	LCT	0.0032
630	Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial	ACADSB	0.0031
2499	Tubulin beta-2C chain	TUBB2C	0.0031
2105	ATP-binding cassette sub-family G member 1	ABCG1	0.0031
825	Arsenical pump-driving ATPase	ASNA1	0.0031
3435	Arsenical pump-driving ATPase	arsA	0.0031
745	Anti-Muellerian hormone type-2 receptor	AMHR2	0.0031
486	Serine/threonine-protein kinase ALS2CR7	CDK15	0.0031
154	AFG3-like protein 2	AFG3L2	0.0031
510	Serine/threonine-protein kinase receptor R3	ACVRL1	0.0031
225	NEDD8-activating enzyme E1 regulatory subunit	NAE1	0.0031
733	Activin receptor type 1B	ACVR1B	0.0031
483	A-Raf proto-oncogene serine/threonine-protein kinase	ARAF	0.0031
377	Beta-adrenergic receptor kinase 1	ADRBK1	0.0031
21	Beta-adrenergic receptor kinase 2	ADRBK2	0.0031
395	ALK tyrosine kinase receptor	Not Available	0.0031
4031	Glutathione S-transferase A1	GSTA1	0.0031
1123	Eosinophil cationic protein	RNASE3	0.0031
484	Tyrosine-protein kinase ABL2	ABL2	0.0031
638	D(3) dopamine receptor	DRD3	0.0031
78	Acetyl-CoA acetyltransferase, mitochondrial	ACAT1	0.0031
3814	Complement C1r subcomponent	C1R	0.0031
6228	Nuclear receptor coactivator 1	NCOA1	0.003
514	Potassium voltage-gated channel subfamily H member 6	KCNH6	0.003
772	Potassium voltage-gated channel subfamily H member 7	KCNH7	0.003
590	5-hydroxytryptamine 2C receptor	HTR2C	0.003
976	Platelet glycoprotein IX	GP9	0.003
6241	Nuclear receptor coactivator 2	NCOA2	0.003
3426	Glutamine synthetase	glnA	0.003
3987	Glutamine synthetase	GLUL	0.003
147	Aldehyde dehydrogenase, mitochondrial	ALDH2	0.0029
1714	Mitogen-activated protein kinase 3	MAPK3	0.0029
268	Adenosine A2b receptor	ADORA2B	0.0029
357	Carbonic anhydrase 2	CA2	0.0029
292	Activin receptor type-1	ACVR1	0.0029
629	Alpha-2B adrenergic receptor	ADRA2B	0.0029
849	Activated CDC42 kinase 1	TNK2	0.0028
3610	Thioredoxin reductase 1, cytoplasmic	TXNRD1	0.0028
5126	Arginase	rocF	0.0027
821	Acetyl-coenzyme A synthetase 2-like, mitochondrial	ACSS1	0.0027
704	Long-chain-fatty-acid--CoA ligase 1	ACSL1	0.0027
386	Acetyl-coenzyme A synthetase, cytoplasmic	ACSS2	0.0027
297	Adenylate cyclase type 1	ADCY1	0.0027
6232	Guanine nucleotide-binding protein G(s) subunit alpha isoforms short	GNAS	0.0027
6233	Adenylate cyclase type 2	ADCY2	0.0027
6234	Adenylate cyclase type 5	ADCY5	0.0027
158	Sodium channel protein type 1 subunit alpha	SCN1A	0.0027
289	Cytosolic purine 5'-nucleotidase	NT5C2	0.0027
778	Cysteinyl leukotriene receptor 1	CYSLTR1	0.0027
4785	Ig gamma-1 chain C region	IGHG1	0.0027
5997	Tumor necrosis factor ligand superfamily member 11	TNFSF11	0.0026
748	5'-AMP-activated protein kinase catalytic subunit alpha-1	PRKAA1	0.0025
1385	Angiotensin-converting enzyme 2	ACE2	0.0025
319	Opioid receptor, sigma 1	OPRS1	0.0024
4160	Voltage-dependent calcium channel subunit alpha-2/delta-2	CACNA2D2	0.0024
1176	Mitogen-activated protein kinase 1	MAPK1	0.0024
3802	Sodium channel protein type 2 subunit alpha	SCN2A	0.0024
280	4-aminobutyrate aminotransferase, mitochondrial	ABAT	0.0023
217	Estradiol 17-beta-dehydrogenase 1	HSD17B1	0.0023
4103	Proteasome subunit beta type 2	PSMB2	0.0023
4102	Proteasome subunit beta type 5	PSMB5	0.0023
4101	Proteasome subunit beta type 1	PSMB1	0.0023
4221	Vascular endothelial growth factor	VEGF	0.0023
5816	Cadherin-5	CDH5	0.0023
740	Argininosuccinate synthase	ASS1	0.0023
865	Argininosuccinate synthase	ASS1	0.0023
2680	Argininosuccinate synthase	argG	0.0023
3194	Argininosuccinate synthase	argG	0.0023
713	Sodium-dependent dopamine transporter	SLC6A3	0.0023
661	ADP/ATP translocase 1	SLC25A4	0.0023
6021	Adenosine kinase	ADK	0.0023
624	Guanidinoacetate N-methyltransferase	GAMT	0.0022
242	Asparagine synthetase [glutamine-hydrolyzing]	ASNS	0.0022
541	cAMP-specific 3',5'-cyclic phosphodiesterase 4B	PDE4B	0.0022
3014	Ribonuclease UK114	HRSP12	0.0022
3718	Hydrogen peroxide-inducible genes activator	oxyR	0.0022
3617	Non-heme chloroperoxidase	cpo	0.0022
5426	Non-heme chloroperoxidase	cpo	0.0022
5428	Replication protein	repA	0.0022
5427	Hydroxyquinol 1,2-dioxygenase	chqB	0.0022
3018	HTH-type transcriptional regulator malT	malT	0.0022
3830	Calreticulin	CALR	0.0022
760	Fibroblast growth factor 1	FGF1	0.0022
716	5-hydroxytryptamine 7 receptor	HTR7	0.0021
296	Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial	MTHFD2	0.0021
378	Alpha-2C adrenergic receptor	ADRA2C	0.0021
3876	Aromatic-L-amino-acid decarboxylase	DDC	0.0021
1561	Troponin C, slow skeletal and cardiac muscles	TNNC1	0.002
1656	CYP2B protein	CYP2B	0.002
6034	Hydroxyindole O-methyltransferase	ASMT	0.002
6035	Nuclear receptor ROR-beta	RORB	0.002
6036	Eosinophil peroxidase	EPX	0.002
679	C-1-tetrahydrofolate synthase, cytoplasmic	MTHFD1	0.002
2107	Microtubule-associated protein 1A	MAP1A	0.002
6087	Gamma-aminobutyric acid receptor subunit gamma-1	GABRG1	0.0019
6093	Gamma-aminobutyric acid receptor subunit delta	GABRD	0.0019
6089	Gamma-aminobutyric acid receptor subunit epsilon	GABRE	0.0019
2958	Probable tautomerase ydcE	pptA	0.0019
2573	Cocaine esterase	cocE	0.0019
7263	Cocaine esterase	Not Available	0.0019
1638	Solute carrier family 2, facilitated glucose transporter member 2	SLC2A2	0.0019
239	Coagulation factor X	F10	0.0019
2936	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0019
5184	Oxygen-insensitive NAD(P)H nitroreductase	nfnB	0.0019
3115	Ras-related protein Rab-9	RAB9A	0.0019
4098	Gamma-aminobutyric-acid receptor subunit beta-1	GABRB1	0.0018
3603	Chlorocatechol 1,2-dioxygenase	clcA	0.0018
3920	Methylenetetrahydrofolate reductase intermediate form	MTHFR	0.0018
3763	5,10-methylenetetrahydrofolate reductase	metF	0.0018
3918	5,10-methylenetetrahydrofolate reductase	MTHFR	0.0018
5094	5,10-methylenetetrahydrofolate reductase	metF	0.0018
59	AMT protein	AMT	0.0018
3919	Methionyl-tRNA formyltransferase, mitochondrial	MTFMT	0.0018
1202	10-formyltetrahydrofolate dehydrogenase	ALDH1L1	0.0018
765	Indoleamine 2,3-dioxygenase	IDO1	0.0017
6047	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A	PDE1A	0.0017
1119	Peroxiredoxin-5, mitochondrial	PRDX5	0.0016
571	Melatonin receptor type 1A	MTNR1A	0.0016
362	Melatonin receptor type 1B	MTNR1B	0.0016
579	Alcohol dehydrogenase class 4 mu/sigma chain	ADH7	0.0016
5692	Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B	PDE1B	0.0016
6766	O-GlcNAcase BT_4395	BT_4395	0.0016
5300	Antigen peptide transporter 1	TAP1	0.0016
750	Voltage-dependent calcium channel gamma-1 subunit	CACNG1	0.0016
816	Biliverdin reductase A	BLVRA	0.0015
792	Aldehyde dehydrogenase, dimeric NADP-preferring	ALDH3A1	0.0015
316	4-trimethylaminobutyraldehyde dehydrogenase	ALDH9A1	0.0015
6755	Poliovirus receptor	PVR	0.0015
646	Malate dehydrogenase, cytoplasmic	MDH1	0.0015
350	3-hydroxyacyl-CoA dehydrogenase type-2	HSD17B10	0.0015
178	NADH-cytochrome b5 reductase 3	CYB5R3	0.0015
812	Dihydrolipoyl dehydrogenase, mitochondrial	DLD	0.0015
454	Peroxisomal multifunctional enzyme type 2	HSD17B4	0.0015
328	Sorbitol dehydrogenase	SORD	0.0015
597	Dihydropteridine reductase	QDPR	0.0015
363	NADP-dependent malic enzyme, mitochondrial	ME3	0.0015
12	Alcohol dehydrogenase class 3	ADH5	0.0015
605	Fumarate reductase flavoprotein subunit	frdA	0.0015
2709	Fumarate reductase flavoprotein subunit	SO_0970	0.0015
3673	Fumarate reductase flavoprotein subunit	fccA	0.0015
4912	Fumarate reductase flavoprotein subunit	ifcA	0.0015
6549	Fumarate reductase flavoprotein subunit	frdA	0.0015
1770	Phospholipase C	PLCL1	0.0015
2841	Phospholipase C	plc	0.0015
1759	85 kDa calcium-independent phospholipase A2	PLA2G6	0.0015
419	Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial	HADH	0.0014
77	L-lactate dehydrogenase B chain	LDHB	0.0014
2693	Heat-labile enterotoxin B chain	eltB	0.0014
4674	2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase	cumD	0.0014
3884	SHMT2 protein	SHMT2	0.0014
3901	SHMT2 protein	SHMT2	0.0014
3885	Hypothetical protein DKFZp686P09201	DKFZp686P09201	0.0014
3879	Serine hydroxymethyltransferase 2	Not Available	0.0014
321	Serine hydroxymethyltransferase, mitochondrial	SHMT2	0.0014
2129	Sucrase-isomaltase, intestinal	SI	0.0014
6645	D-amino-acid oxidase	DAO	0.0014
599	Glyceraldehyde-3-phosphate dehydrogenase	GAPDH	0.0014
4426	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0014
4454	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0014
4489	Glyceraldehyde-3-phosphate dehydrogenase	gap	0.0014
473	L-lactate dehydrogenase A chain	LDHA	0.0014
794	Glyceraldehyde-3-phosphate dehydrogenase, testis-specific	GAPDHS	0.0014
6169	ATP-binding cassette sub-family A member 5	ABCA5	0.0014
914	Formimidoyltransferase-cyclodeaminase	FTCD	0.0014
166	NAD-dependent malic enzyme, mitochondrial	ME2	0.0013
6091	Gamma-aminobutyric acid receptor subunit theta	GABRQ	0.0013
809	Methionine synthase	MTR	0.0013
2935	Methionine synthase	metH	0.0013
830	Glutamate dehydrogenase 2, mitochondrial	GLUD2	0.0013
528	5-hydroxytryptamine 1E receptor	HTR1E	0.0013
4010	Mitochondrial dicarboxylate carrier	SLC25A10	0.0013
1410	Oxidoreductase	HSD17B6	0.0013
4725	Oxidoreductase	Not Available	0.0013
5124	Oxidoreductase	Not Available	0.0013
4007	Succinate receptor 1	SUCNR1	0.0013
4008	Succinyl-CoA:3-ketoacid-coenzyme A transferase 2, mitochondrial	OXCT2	0.0013
4002	Succinyl-CoA ligase [GDP-forming] subunit alpha, mitochondrial	SUCLG1	0.0013
673	Solute carrier family 13 member 3	SLC13A3	0.0013
391	Succinyl-CoA ligase [GDP-forming] beta-chain, mitochondrial	SUCLG2	0.0013
4009	Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial	SUCLA2	0.0013
498	Solute carrier family 13 member 2	SLC13A2	0.0013
25	Solute carrier family 13 member 1	SLC13A1	0.0013
6432	Transporter	snf	0.0013
3191	Histidinol dehydrogenase	hisD	0.0012
6893	Calcium/calmodulin-dependent protein kinase type II gamma chain	CAMK2G	0.0012
367	Serine hydroxymethyltransferase, cytosolic	SHMT1	0.0012
6086	Gamma-aminobutyric acid receptor subunit gamma-2	GABRG2	0.0012
694	Matrix protein 2	M	0.0012
6090	Gamma-aminobutyric acid receptor subunit pi	GABRP	0.0012
6092	Gamma-aminobutyric acid receptor subunit rho-2	GABRR2	0.0012
6088	Gamma-aminobutyric acid receptor subunit gamma-3	GABRG3	0.0012
6115	Gamma-aminobutyric acid receptor subunit rho-3	GABRR3	0.0012
201	Glutamate dehydrogenase 1, mitochondrial	GLUD1	0.0012
4100	Gamma-aminobutyric-acid receptor subunit beta-2	GABRB2	0.0012
2297	Genome polyprotein	Not Available	0.0012
2322	Genome polyprotein	Not Available	0.0012
2694	Genome polyprotein	Not Available	0.0012
2719	Genome polyprotein	Not Available	0.0012
2860	Genome polyprotein	Not Available	0.0012
2928	Genome polyprotein	Not Available	0.0012
3160	Genome polyprotein	Not Available	0.0012
3260	Genome polyprotein	Not Available	0.0012
4783	Genome polyprotein	Not Available	0.0012
5726	Genome polyprotein	Not Available	0.0012
5779	Genome polyprotein	Not Available	0.0012
5867	Genome polyprotein	Not Available	0.0012
6253	Genome polyprotein	Not Available	0.0012
6301	Genome polyprotein	Not Available	0.0012
6380	Genome polyprotein	Not Available	0.0012
6381	Genome polyprotein	Not Available	0.0012
6437	Genome polyprotein	Not Available	0.0012
6520	Genome polyprotein	Not Available	0.0012
6521	Genome polyprotein	Not Available	0.0012
6652	Genome polyprotein	Not Available	0.0012
6734	Genome polyprotein	Not Available	0.0012
6735	Genome polyprotein	Not Available	0.0012
6736	Genome polyprotein	Not Available	0.0012
6737	Genome polyprotein	Not Available	0.0012
6738	Genome polyprotein	Not Available	0.0012
6739	Genome polyprotein	Not Available	0.0012
6744	Genome polyprotein	Not Available	0.0012
6748	Genome polyprotein	Not Available	0.0012
6894	Genome polyprotein	Not Available	0.0012
6898	Genome polyprotein	Not Available	0.0012
142	Gamma-aminobutyric-acid receptor subunit rho-1	GABRR1	0.0012
611	Retinal dehydrogenase 1	ALDH1A1	0.0012
569	Retinal dehydrogenase 2	ALDH1A2	0.0012
734	D1 dopamine receptor-interacting protein calcyon	CALY	0.0012
4003	Succinyl-CoA:3-ketoacid-coenzyme A transferase 1, mitochondrial	OXCT1	0.0012
6859	Protein S100-A4	S100A4	0.0012
432	D(4) dopamine receptor	DRD4	0.0012
194	NADH dehydrogenase [ubiquinone] 1 subunit C2	NDUFC2	0.0011
707	72 kDa type IV collagenase	MMP2	0.0011
2112	Toll-like receptor 9	TLR9	0.0011
4000	Prolyl 4-hydroxylase subunit alpha-2	P4HA2	0.0011
585	Aspartyl/asparaginyl beta-hydroxylase	ASPH	0.0011
4428	Redox-sensing transcriptional repressor rex	rex	0.0011
3940	Gamma-butyrobetaine dioxygenase	BBOX1	0.0011
4497	Benzyl alcohol dehydrogenase	xylB	0.0011
4423	Levodione reductase	lvr	0.0011
4500	L-lactate dehydrogenase 2	ldh2	0.0011
4449	ADP-ribosyltransferase	Not Available	0.0011
97	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	PLOD1	0.0011
3938	Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3	PLOD3	0.0011
3964	Trimethyllysine dioxygenase, mitochondrial	TMLHE	0.0011
4495	3-oxoacyl-(Acyl carrier protein) reductase	TM_1169	0.0011
4435	L-aspartate dehydrogenase	nadX	0.0011
4446	3alpha-hydroxysteroid dehydrogenase/carbonyl reductase	Not Available	0.0011
3729	Citrate synthase	gltA	0.0011
4575	Citrate synthase	cit	0.0011
4580	Citrate synthase	gltA	0.0011
4505	Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase	bphB	0.0011
4456	Inorganic polyphosphate/ATP-NAD kinase	ppnK	0.0011
4447	Hypothetical protein yhfP	yhfP	0.0011
4336	Glyceraldehyde 3-phosphate dehydrogenase	Not Available	0.0011
4436	Glyceraldehyde 3-phosphate dehydrogenase	tthHB8IM	0.0011
4414	Dehydrogenase	TT_P0035	0.0011
2350	3-isopropylmalate dehydrogenase	leuB	0.0011
3092	3-isopropylmalate dehydrogenase	leuB	0.0011
4418	AGR_L_3209p	AGR_L_3209	0.0011
4507	Alanine dehydrogenase	ald	0.0011
4475	Hypothetical protein Rv0046c/MT0052	ino1	0.0011
4455	Glycerol dehydrogenase	gldA	0.0011
4506	Myo-inositol-1-phosphate synthase-related protein	TM_1419	0.0011
3735	NAD(P) transhydrogenase subunit alpha part 1	pntAA	0.0011
4448	L-2-hydroxyisocaproate dehydrogenase	Not Available	0.0011
4466	Glutathione-independent formaldehyde dehydrogenase	fdhA	0.0011
4502	Formate dehydrogenase	Not Available	0.0011
4487	Transcriptional regulator nadR	nadR	0.0011
4451	Vip2Ac	vip2Ac	0.0011
4472	Glucose 1-dehydrogenase	Not Available	0.0011
4443	Quinate/shikimate dehydrogenase	ydiB	0.0011
4471	CDP-D-glucose-4,6-dehydratase	ascB	0.0011
4467	Alpha-glucosidase, putative	TM_0752	0.0011
6459	Glycodelin	PAEP	0.0011
1618	High affinity nerve growth factor receptor	NTRK1	0.0011
4006	Succinate dehydrogenase cytochrome b560 subunit, mitochondrial	SDHC	0.0011
4001	Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial	SDHB	0.0011
427	Substance-P receptor	TACR1	0.0011
144	Hemoglobin subunit alpha	HBA1	0.001
106	Cannabinoid receptor 2	CNR2	0.001
3949	Prolyl 3-hydroxylase 2	LEPREL1	0.001
3945	Prolyl 3-hydroxylase 1	LEPRE1	0.001
3951	Prolyl 3-hydroxylase 3	LEPREL2	0.001
6174	50S ribosomal protein L32	rpmF	0.001
4203	Histamine N-methyltransferase	HNMT	0.001
3999	Succinate dehydrogenase [ubiquinone] cytochrome b small subunit, mitochondrial	SDHD	0.001
811	Translocator protein	TSPO	0.001
2473	Tyrosine-protein kinase CSK	CSK	0.001
2398	Tyrosine-protein kinase ZAP-70	ZAP70	0.001
68	Cannabinoid receptor 1	CNR1	0.001
67	Prolyl 4-hydroxylase subunit alpha-1	P4HA1	0.001
936	Ephrin type-A receptor 2	EPHA2	0.0009
4486	Phenol 2-hydroxylase component B	pheA2	0.0009
4427	TDP-glucose-4,6-dehydratase	desIV	0.0009
3177	dTDP-glucose 4,6-dehydratase	rfbB	0.0009
4499	dTDP-glucose 4,6-dehydratase	rmlB	0.0009
4484	2,5-diketo-D-gluconic acid reductase A	dkgA	0.0009
3598	dTDP-4-dehydrorhamnose reductase	rfbD	0.0009
4439	Ferredoxin reductase	bphA4	0.0009
2967	CDP-paratose 2-epimerase	rfbE	0.0009
4482	UDP-galactose 4-epimerase	galE	0.0009
4503	NADPH-flavin oxidoreductase	frp	0.0009
4477	Dihydrolipoyl dehydrogenase	lpdV	0.0009
5077	Dihydrolipoyl dehydrogenase	Not Available	0.0009
5117	Dihydrolipoyl dehydrogenase	lpd	0.0009
2507	Diphtheria toxin	Not Available	0.0009
4509	Acetoin(diacetyl) reductase	budC	0.0009
3615	Dihydrodipicolinate reductase	dapB	0.0009
3618	Dihydrodipicolinate reductase	dapB	0.0009
4462	Dihydrodipicolinate reductase	dapB	0.0009
1199	GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1	ART1	0.0009
2393	Maltose-6'-phosphate glucosidase	glvA	0.0009
2591	Urocanate hydratase	hutU	0.0009
2538	6-phospho-beta-glucosidase bglT	bglT	0.0009
126	D-lactate dehydrogenase	dld	0.0009
3545	D-lactate dehydrogenase	Not Available	0.0009
4510	D-lactate dehydrogenase	ldhA	0.0009
6698	Dehydrogenase/reductase SDR family member 4-like 2	DHRS4L2	0.0009
3081	3-dehydroquinate synthase	aroB	0.0009
3087	Nicotinate-nucleotide adenylyltransferase	nadD	0.0009
4469	Nicotinate-nucleotide adenylyltransferase	nadD	0.0009
2831	3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	Not Available	0.0009
3059	3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase	fabG3	0.0009
2424	L-lactate dehydrogenase	ldh	0.0009
2641	L-lactate dehydrogenase	Not Available	0.0009
4437	L-lactate dehydrogenase	ldh	0.0009
4442	L-lactate dehydrogenase	ldh	0.0009
4450	Iota toxin component Ia	Not Available	0.0009
3401	D-2-hydroxyisocaproate dehydrogenase	Not Available	0.0009
4496	C-terminal-binding protein 1	CTBP1	0.0009
2881	Gamma-aminobutyraldehyde dehydrogenase	prr	0.0009
2018	Deoxyhypusine synthase	DHPS	0.0009
2336	2,3-diketo-L-gulonate reductase	dlgD	0.0009
4498	Ornithine cyclodeaminase	PP3533	0.0009
741	Potassium voltage-gated channel subfamily KQT member 1	KCNQ1	0.0009
990	Dual specificity mitogen-activated protein kinase kinase 1	MAP2K1	0.0009
360	Ribonucleoside-diphosphate reductase large subunit	RRM1	0.0009
2240	Cell division protein kinase 2	CDK2	0.0009
564	Cellular retinoic acid-binding protein 1	CRABP1	0.0009
859	Cellular retinoic acid-binding protein 2	CRABP2	0.0009
2683	Mono-ADP-ribosyltransferase C3	C3	0.0009
1262	Corticotropin-lipotropin	POMC	0.0009
4504	WbpP	Not Available	0.0008
3296	Nicotinamide mononucleotide adenylyltransferase 1	NMNAT1	0.0008
3367	GDP-mannose 6-dehydrogenase	algD	0.0008
4440	NADH peroxidase	npr	0.0008
4318	Siroheme synthase	cysG	0.0008
2799	Glyceraldehyde-3-phosphate dehydrogenase, glycosomal	Not Available	0.0008
4343	Alpha-glucosidase	aglA	0.0008
3736	Glyceraldehyde-3-phosphate dehydrogenase A	gapA	0.0008
3616	Fatty acid-binding protein, epidermal	FABP5	0.0008
5433	UPF0230 protein TM_1468	TM_1468	0.0008
5430	Hepatocyte nuclear factor 4-gamma	HNF4G	0.0008
5431	Lipid binding protein	Not Available	0.0008
2617	Nitric oxide synthase oxygenase	nos	0.0008
2701	Nitric oxide synthase oxygenase	nos	0.0008
229	Retinoic acid receptor beta	RARB	0.0008
780	Retinoic acid receptor RXR-gamma	RXRG	0.0008
2826	Glucose--fructose oxidoreductase	gfo	0.0008
1799	Glucose-6-phosphate 1-dehydrogenase	G6PD	0.0008
2630	Glucose-6-phosphate 1-dehydrogenase	zwf	0.0008
3333	Nicotinamide mononucleotide adenylyltransferase 3	NMNAT3	0.0008
2434	NH(3)-dependent NAD(+) synthetase	nadE	0.0008
2910	NH(3)-dependent NAD(+) synthetase	nadE	0.0008
3217	NH(3)-dependent NAD(+) synthetase	nadE	0.0008
3070	Adenosylhomocysteinase	AHCY	0.0008
4424	Adenosylhomocysteinase	PFE1050w	0.0008
6278	Adenosylhomocysteinase	ahcY	0.0008
5325	2,4-dienoyl-CoA reductase, mitochondrial	DECR1	0.0008
730	Retinoic acid receptor alpha	RARA	0.0008
63	Malate dehydrogenase	mdh	0.0008
2329	Malate dehydrogenase	mdh	0.0008
3445	Malate dehydrogenase	mdh	0.0008
4420	Malate dehydrogenase	mdh	0.0008
4438	Malate dehydrogenase	mdh	0.0008
6179	UDP-glucuronosyltransferase 2B17	UGT2B17	0.0008
2530	Protein kinase C theta type	PRKCQ	0.0008
5766	NAD-dependent deacetylase sirtuin-5	SIRT5	0.0008
327	Glutathione reductase	gor	0.0008
5110	Glutathione reductase	GR2	0.0008
459	Retinoic acid receptor RXR-alpha	RXRA	0.0007
635	Estradiol 17-beta-dehydrogenase 8	HSD17B8	0.0007
666	NADP-dependent malic enzyme	ME1	0.0007
88	Retinoic acid receptor RXR-beta	RXRB	0.0007
857	Malate dehydrogenase, mitochondrial	MDH2	0.0007
4491	DNA ligase, NAD-dependent	ligA	0.0007
162	Retinoic acid receptor gamma-1	RARG	0.0007
2286	Isocitrate dehydrogenase [NADP]	icd	0.0007
2302	Isocitrate dehydrogenase [NADP]	icd	0.0007
2771	Isocitrate dehydrogenase [NADP]	icd	0.0007
11	NAD(P) transhydrogenase, mitochondrial	NNT	0.0007
839	Short-chain specific acyl-CoA dehydrogenase, mitochondrial	ACADS	0.0007
74	Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial	DLAT	0.0007
163	D(1B) dopamine receptor	DRD5	0.0007
2762	UDP-glucose 4-epimerase	GALE	0.0007
3461	UDP-glucose 4-epimerase	galE	0.0007
247	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1	NDUFA1	0.0007
190	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4	NDUFA4	0.0007
353	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2	NDUFA4L2	0.0007
598	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11	NDUFA11	0.0007
313	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3	NDUFB3	0.0007
607	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2	NDUFA2	0.0007
300	NADH-ubiquinone oxidoreductase chain 4L	MT-ND4L	0.0007
374	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NDUFB1	0.0007
475	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial	NDUFB2	0.0007
30	NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial	NDUFV3	0.0007
446	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7	NDUFA7	0.0007
417	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6	NDUFB6	0.0007
343	NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial	NDUFC1	0.0007
755	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3	NDUFA3	0.0007
602	Acyl carrier protein, mitochondrial	NDUFAB1	0.0007
405	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8	NDUFA8	0.0007
384	NADH-ubiquinone oxidoreductase chain 6	MT-ND6	0.0007
555	NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial	NDUFS4	0.0007
99	NADH dehydrogenase [ubiquinone] iron-sulfur protein 5	NDUFS5	0.0007
270	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial	NDUFB5	0.0007
525	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5	NDUFA5	0.0007
219	NADH-ubiquinone oxidoreductase chain 3	MT-ND3	0.0007
41	NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial	NDUFS8	0.0007
104	NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial	NDUFS6	0.0007
236	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6	NDUFA6	0.0007
324	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4	NDUFB4	0.0007
568	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7	NDUFB7	0.0007
152	NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial	NDUFV2	0.0007
582	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13	NDUFA13	0.0007
829	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12	NDUFA12	0.0007
609	15-hydroxyprostaglandin dehydrogenase [NAD+]	HPGD	0.0007
608	NADH-ubiquinone oxidoreductase chain 4	MT-ND4	0.0007
272	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10	NDUFB10	0.0007
372	Estradiol 17-beta-dehydrogenase 3	HSD17B3	0.0007
656	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9	NDUFB9	0.0007
729	GDP-L-fucose synthetase	TSTA3	0.0007
3463	GDP-L-fucose synthetase	fcl	0.0007
487	Aldo-keto reductase family 1 member C4	AKR1C4	0.0007
746	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial	NDUFB8	0.0007
531	Aldehyde dehydrogenase X, mitochondrial	ALDH1B1	0.0007
167	L-lactate dehydrogenase C chain	LDHC	0.0007
141	3-hydroxyisobutyrate dehydrogenase, mitochondrial	HIBADH	0.0007
288	Trifunctional enzyme subunit alpha, mitochondrial	HADHA	0.0007
258	Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial	ALDH6A1	0.0007
196	D-beta-hydroxybutyrate dehydrogenase, mitochondrial	BDH1	0.0007
721	NADH-ubiquinone oxidoreductase chain 2	MT-ND2	0.0007
231	Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic	GPD1	0.0007
91	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial	NDUFA10	0.0007
14	Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial	IDH3A	0.0007
112	L-lactate dehydrogenase A-like 6B	LDHAL6B	0.0007
216	Aldehyde dehydrogenase 3B2	ALDH3B2	0.0007
616	Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial	IDH3B	0.0007
9	Estradiol 17-beta-dehydrogenase 2	HSD17B2	0.0007
671	Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial	PDHA2	0.0007
628	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial	PDHA1	0.0007
848	Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial	IDH3G	0.0007
145	Corticosteroid 11-beta-dehydrogenase isozyme 2	HSD11B2	0.0007
496	Aldehyde dehydrogenase 3B1	ALDH3B1	0.0007
34	7-dehydrocholesterol reductase	DHCR7	0.0007
662	Fatty aldehyde dehydrogenase	ALDH3A2	0.0007
711	UDP-glucose 6-dehydrogenase	UGDH	0.0007
3672	UDP-glucose 6-dehydrogenase	hasB	0.0007
149	Alpha-aminoadipic semialdehyde dehydrogenase	ALDH7A1	0.0007
107	C-4 methylsterol oxidase	SC4MOL	0.0007
180	D-3-phosphoglycerate dehydrogenase	PHGDH	0.0007
3726	D-3-phosphoglycerate dehydrogenase	serA	0.0007
4291	D-3-phosphoglycerate dehydrogenase	serA	0.0007
644	Heme oxygenase 2	HMOX2	0.0007
4982	Heme oxygenase 2	pbsA2	0.0007
271	Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial	ALDH4A1	0.0007
326	L-lactate dehydrogenase A-like 6A	LDHAL6A	0.0007
637	NADH-ubiquinone oxidoreductase chain 5	MT-ND5	0.0007
206	3-keto-steroid reductase	HSD17B7	0.0007
50	Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating	NSDHL	0.0007
335	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial	NDUFA9	0.0007
643	Peroxisomal bifunctional enzyme	EHHADH	0.0007
548	NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial	NDUFS1	0.0007
393	GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase	H6PD	0.0007
539	NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial	NDUFV1	0.0007
283	SEC14-like protein 2	SEC14L2	0.0007
2408	Tyrosine-protein kinase SYK	SYK	0.0007
2511	MAP kinase-activated protein kinase 2	MAPKAPK2	0.0007
1256	5-hydroxytryptamine 6 receptor	HTR6	0.0007
5432	Trafficking protein particle complex subunit 3	TRAPPC3	0.0007
1374	Natriuretic peptides B	NPPB	0.0006
1827	Gap junction alpha-1 protein	GJA1	0.0006
1908	Vascular cell adhesion protein 1	VCAM1	0.0006
935	Proto-oncogene tyrosine-protein kinase Yes	YES1	0.0006
1063	Signal transducer and activator of transcription 5B	STAT5B	0.0006
83	Alpha-aminoadipic semialdehyde synthase, mitochondrial	AASS	0.0006
814	Ryanodine receptor 1	RYR1	0.0006
6026	Alcohol dehydrogenase 6	ADH6	0.0006
654	Flavin reductase	BLVRB	0.0006
6098	Potassium voltage-gated channel subfamily D member 2	KCND2	0.0006
6099	Potassium voltage-gated channel subfamily D member 3	KCND3	0.0006
810	Heme oxygenase 1	HMOX1	0.0006
3391	Heme oxygenase 1	pbsA1	0.0006
248	Pyrroline-5-carboxylate reductase 1	PYCR1	0.0006
802	Pyrroline-5-carboxylate reductase 2	PYCR2	0.0006
627	11-cis retinol dehydrogenase	RDH5	0.0006
640	Aldehyde dehydrogenase 1A3	ALDH1A3	0.0006
626	Cysteine dioxygenase type 1	CDO1	0.0006
174	Sigma 1-type opioid receptor	SIGMAR1	0.0006
368	Enoyl-[acyl-carrier-protein] reductase [NADH]	inhA	0.0006
3228	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0006
3678	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0006
6856	Enoyl-[acyl-carrier-protein] reductase [NADH]	fabI	0.0006
110	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	PDHB	0.0006
66	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II	HSD3B2	0.0006
6046	Voltage-gated calcium channel beta 1 subunit splice variant CavB1d	CACNB1	0.0006
934	Proto-oncogene tyrosine-protein kinase Fyn	FYN	0.0006
6048	Troponin C, skeletal muscle	TNNC2	0.0006
1721	Glycogen synthase kinase-3 beta	GSK3B	0.0005
57	3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I	HSD3B1	0.0005
3238	Multidrug resistance protein mexA	mexA	0.0005
3116	Bacterioferritin	bfr	0.0005
4906	Bacterioferritin	bfr	0.0005
4965	Bacterioferritin	bfr	0.0005
3173	Enolase	eno	0.0005
3709	Glycerol uptake facilitator protein	glpF	0.0005
3336	C4-dicarboxylate transport transcriptional regulatory protein dctD	dctD	0.0005
3393	TGF-beta receptor type-2	TGFBR2	0.0005
5489	Ribonucleoside-diphosphate reductase 1 subunit beta	nrdB	0.0005
6045	Voltage-dependent calcium channel subunit alpha-2/delta-3	CACNA2D3	0.0005
279	Tyrosinase	TYR	0.0005
5798	Mitogen-activated protein kinase 11	MAPK11	0.0005
464	Glutamate [NMDA] receptor subunit epsilon-2	GRIN2B	0.0005
822	Aldose reductase	AKR1B1	0.0005
458	Neuronal acetylcholine receptor subunit alpha-10	CHRNA10	0.0005
233	Potassium channel subfamily K member 2	KCNK2	0.0005
1864	RET proto-oncogene	RET	0.0005
1950	Epithelial discoidin domain-containing receptor 1	DDR1	0.0005
6170	ATP-binding cassette sub-family A member 3	ABCA3	0.0005
6094	BCR/ABL fusion protein isoform X9	BCR/ABL fusion	0.0005
2852	DNA mismatch repair protein mutL	mutL	0.0005
1275	Estrogen sulfotransferase	SULT1E1	0.0005
5278	Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1	PAPSS1	0.0005
3221	Cytochrome c4	cc4	0.0005
6933	Calcium-activated potassium channel subunit beta-4	KCNMB4	0.0004
6931	Calcium-activated potassium channel subunit beta-1	KCNMB1	0.0004
6934	Small conductance calcium-activated potassium channel protein 1	KCNN1	0.0004
6935	Small conductance calcium-activated potassium channel protein 2	KCNN2	0.0004
6932	Calcium-activated potassium channel subunit beta-3	KCNMB3	0.0004
6936	Small conductance calcium-activated potassium channel protein 3	KCNN3	0.0004
6102	Arylamine N-acetyltransferase 2	NAT2	0.0004
4311	tRNA	TRDMT1	0.0004
4325	tRNA	trmD	0.0004
4328	tRNA	trmD	0.0004
4692	A/G-specific adenine glycosylase	mutY	0.0004
1360	Sphingomyelin phosphodiesterase	SMPD1	0.0004
5463	Calcium-activated potassium channel subunit beta 2	KCNMB2	0.0004
276	Sodium- and chloride-dependent GABA transporter 1	SLC6A1	0.0004
2802	Endoglucanase G	celCCG	0.0004
6316	ADP-ribosylation factor 1	ARF1	0.0004
6100	BDNF/NT-3 growth factors receptor	NTRK2	0.0004
295	Carbonic anhydrase 1	CA1	0.0003
610	Calcium-activated potassium channel subunit alpha 1	KCNMA1	0.0003
164	Histamine H4 receptor	HRH4	0.0003

(*) Categorization taken from DrugBank: therapeutic category or general category of a drug (i.e. anti-convulsant, antibacterial, etc.)

DB02659 - Cholic Acid

Targets

Transporters

Carriers

Predictions