DT-Web

DB01213 - Fomepizole


Identification
Name Fomepizole
Accession Number DB01213 (APRD00985)
Type small molecule
Description Fomepizole is used as an antidote in confirmed or suspected methanol or ethylene glycol poisoning. Fomepizole is a competitive inhibitor of alcohol dehydrogenase, the enzyme that catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 82.1038
Groups approved
Monoisotopic Weight 82.053098202
Pharmacology
Indication Antizol is indicated as an antidote for ethylene glycol (such as antifreeze) or methanol poisoning, or for use in suspected ethylene glycol or methanol ingestion, either alone or in combination with hemodialysis
Mechanism of action Antizol (fomepizole) is a competitive inhibitor of alcohol dehydrogenase. Alcohol dehydrogenase catalyzes the oxidation of ethanol to acetaldehyde. Alcohol dehydrogenase also catalyzes the initial steps in the metabolism of ethylene glycol and methanol to their toxic metabolites.
Absorption Rapid and complete
Protein binding Not Available
Biotransformation Primarily hepaticm the primary metabolite is 4-carboxypyrazole (approximately 80 to 85% of an administered dose). Other metabolites include 4-hydroxymethylpyrazole and the N -glucuronide conjugates of 4-carboxypyrazole and 4-hydroxymethylpyrazole.
Route of elimination In healthy volunteers, only 1-3.5% of the administered dose of Antizol(R) (7-20 mg/kg oral and IV) was excreted unchanged in the urine, indicating that metabolism is the major route of elimination. In humans, the primary metabolite of Antizol(R) is 4-carboxypyrazole (approximately 80-85% of administered dose), which is excreted in the urine. The metabolites of Antizol(R) are excreted renally.
Toxicity Headache, nausea, dizziness
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Alcohol dehydrogenase 1A
Name Alcohol dehydrogenase 1A
Gene Name ADH1A
Pharmacological action yes
Actions inhibitor
References
  • Nagata H, Sekizuka E, Morishita T, Tatemichi M, Kurokawa T, Mizuki A, Ishii H: Adenosine A2-receptor mediates ethanol-induced arteriolar dilation in rat stomach. Am J Physiol. 1996 Dec;271(6 Pt 1):G1028-33. - Pubmed
  • Mukherjee PK, Mohamed S, Chandra J, Kuhn D, Liu S, Antar OS, Munyon R, Mitchell AP, Andes D, Chance MR, Rouabhia M, Ghannoum MA: Alcohol dehydrogenase restricts the ability of the pathogen Candida albicans to form a biofilm on catheter surfaces through an ethanol-based mechanism. Infect Immun. 2006 Jul;74(7):3804-16. - Pubmed
  • Nussrallah BA, Dam R, Wagner FW: Characterization of Coturnix quail liver alcohol dehydrogenase enzymes. Biochemistry. 1989 Jul 25;28(15):6245-51. - Pubmed
  • Brent J: Fomepizole for ethylene glycol and methanol poisoning. N Engl J Med. 2009 May 21;360(21):2216-23. - Pubmed
  • Calello DP, Osterhoudt KC, Henretig FM: New and novel antidotes in pediatrics. Pediatr Emerg Care. 2006 Jul;22(7):523-30. - Pubmed
  • Betten DP, Vohra RB, Cook MD, Matteucci MJ, Clark RF: Antidote use in the critically ill poisoned patient. J Intensive Care Med. 2006 Sep-Oct;21(5):255-77. - Pubmed
DTHybrid score 0.6702
Alcohol dehydrogenase 1B
Name Alcohol dehydrogenase 1B
Gene Name ADH1B
Pharmacological action yes
Actions inhibitor
References
  • Yin SJ, Liao CS, Chen CM, Fan FT, Lee SC: Genetic polymorphism and activities of human lung alcohol and aldehyde dehydrogenases: implications for ethanol metabolism and cytotoxicity. Biochem Genet. 1992 Apr;30(3-4):203-15. - Pubmed
  • Eriksson CJ, Fukunaga T, Sarkola T, Chen WJ, Chen CC, Ju JM, Cheng AT, Yamamoto H, Kohlenberg-Muller K, Kimura M, Murayama M, Matsushita S, Kashima H, Higuchi S, Carr L, Viljoen D, Brooke L, Stewart T, Foroud T, Su J, Li TK, Whitfield JB: Functional relevance of human adh polymorphism. Alcohol Clin Exp Res. 2001 May;25(5 Suppl ISBRA):157S-163S. - Pubmed
  • Kassam JP, Tang BK, Kadar D, Kalow W: In vitro studies of human liver alcohol dehydrogenase variants using a variety of substrates. Drug Metab Dispos. 1989 Sep-Oct;17(5):567-72. - Pubmed
  • Brent J: Fomepizole for ethylene glycol and methanol poisoning. N Engl J Med. 2009 May 21;360(21):2216-23. - Pubmed
  • Calello DP, Osterhoudt KC, Henretig FM: New and novel antidotes in pediatrics. Pediatr Emerg Care. 2006 Jul;22(7):523-30. - Pubmed
  • Betten DP, Vohra RB, Cook MD, Matteucci MJ, Clark RF: Antidote use in the critically ill poisoned patient. J Intensive Care Med. 2006 Sep-Oct;21(5):255-77. - Pubmed
DTHybrid score 0.8861
Alcohol dehydrogenase 1C
Name Alcohol dehydrogenase 1C
Gene Name ADH1C
Pharmacological action yes
Actions inhibitor
References
  • Eriksson CJ, Fukunaga T, Sarkola T, Chen WJ, Chen CC, Ju JM, Cheng AT, Yamamoto H, Kohlenberg-Muller K, Kimura M, Murayama M, Matsushita S, Kashima H, Higuchi S, Carr L, Viljoen D, Brooke L, Stewart T, Foroud T, Su J, Li TK, Whitfield JB: Functional relevance of human adh polymorphism. Alcohol Clin Exp Res. 2001 May;25(5 Suppl ISBRA):157S-163S. - Pubmed
  • Brent J: Fomepizole for ethylene glycol and methanol poisoning. N Engl J Med. 2009 May 21;360(21):2216-23. - Pubmed
  • Calello DP, Osterhoudt KC, Henretig FM: New and novel antidotes in pediatrics. Pediatr Emerg Care. 2006 Jul;22(7):523-30. - Pubmed
  • Betten DP, Vohra RB, Cook MD, Matteucci MJ, Clark RF: Antidote use in the critically ill poisoned patient. J Intensive Care Med. 2006 Sep-Oct;21(5):255-77. - Pubmed
DTHybrid score 1.4916
Catalase
Name Catalase
Gene Name CAT
Pharmacological action yes
Actions inhibitor
References
  • Thurman RG, McKenna WR, Brentzel HJ Jr, Hesse S: Significant pathways of hepatic ethanol metabolism. Fed Proc. 1975 Oct;34(11):2075-81. - Pubmed
  • Handler JA, Thurman RG: Catalase-dependent ethanol oxidation in perfused rat liver. Requirement for fatty-acid-stimulated H2O2 production by peroxisomes. Eur J Biochem. 1988 Sep 15;176(2):477-84. - Pubmed
  • Bradford BU, Forman DT, Thurman RG: 4-Methylpyrazole inhibits fatty acyl coenzyme synthetase and diminishes catalase-dependent alcohol metabolism: has the contribution of alcohol dehydrogenase to alcohol metabolism been previously overestimated? Mol Pharmacol. 1993 Jan;43(1):115-9. - Pubmed
DTHybrid score 0.2908

Enzymes


Cytochrome P450 2E1
Name Cytochrome P450 2E1
Gene Name CYP2E1
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3042
Cytochrome P450 2A6
Name Cytochrome P450 2A6
Gene Name CYP2A6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3431

Predictions


Id Partner name Gene Name Score
3249 Catalase katA 0.2908
3625 Catalase katA 0.2908
4539 Catalase katA 0.2908
4941 Catalase katB 0.2908
3411 Cytochrome P450 121 cyp121 0.1585
4512 Cytochrome P450 3A4 CYP3A4 0.1219
4757 Cytochrome P450 2C9 CYP2C9 0.1002
4200 Cytochrome P450 1A2 CYP1A2 0.0949
6016 Cytochrome P450 2C19 CYP2C19 0.0882
6030 Cytochrome P450 2B6 CYP2B6 0.0781
4119 Cytochrome P450 2D6 CYP2D6 0.076
6024 Cytochrome P450 1A1 CYP1A1 0.0655
396 Alcohol dehydrogenase 4 ADH4 0.0632
4924 Cytochrome P450 2C8 CYP2C8 0.0586
3381 Alcohol dehydrogenase Not Available 0.049
4508 Alcohol dehydrogenase adhA 0.049
1588 Multidrug resistance protein 1 ABCB1 0.0447
468 Cytochrome P450 4A11 CYP4A11 0.0372
1758 GTPase HRas HRAS 0.0355
482 Glycine receptor subunit alpha-1 GLRA1 0.0348
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0323
4118 Cytochrome P450 3A5 CYP3A5 0.0316
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0297
820 Glycine receptor subunit alpha-2 GLRA2 0.0287
6107 Cytochrome P450 3A7 CYP3A7 0.0256
20 Prostaglandin G/H synthase 1 PTGS1 0.0234
3811 Cytochrome P450 19A1 CYP19A1 0.0219
6106 Cytochrome P450 2C18 CYP2C18 0.0209
587 Serum albumin ALB 0.0151
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0146
3221 Cytochrome c4 cc4 0.0145
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0136
6014 Cytochrome P450 2A13 CYP2A13 0.0132
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0131
3191 Histidinol dehydrogenase hisD 0.013
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0125
492 Histamine H1 receptor HRH1 0.0123
442 Envelope glycoprotein gp41 0.012
4859 Envelope glycoprotein env 0.012
260 Cytochrome P450 51 ERG11 0.012
761 Cytochrome P450 51 ERG11 0.012
3163 Cytochrome P450 51 cyp51 0.012
1898 Cytochrome P450 1B1 CYP1B1 0.0116
290 Prostaglandin G/H synthase 2 PTGS2 0.0116
3116 Bacterioferritin bfr 0.0115
4906 Bacterioferritin bfr 0.0115
4965 Bacterioferritin bfr 0.0115
3709 Glycerol uptake facilitator protein glpF 0.0115
3238 Multidrug resistance protein mexA mexA 0.0115
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0115
3393 TGF-beta receptor type-2 TGFBR2 0.0115
3173 Enolase eno 0.0115
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0115
646 Malate dehydrogenase, cytoplasmic MDH1 0.0112
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0112
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0112
518 Peroxidase/catalase T katG 0.0111
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0111
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0111
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0107
537 ATP synthase delta chain, mitochondrial ATP5D 0.0105
776 Bile salt export pump ABCB11 0.0104
6102 Arylamine N-acetyltransferase 2 NAT2 0.0104
1729 Solute carrier family 22 member 6 SLC22A6 0.0103
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0103
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0102
2852 DNA mismatch repair protein mutL mutL 0.01
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0098
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0098
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0098
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0098
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0096
473 L-lactate dehydrogenase A chain LDHA 0.0095
705 Glutamate receptor 1 GRIA1 0.0094
824 Sodium-dependent serotonin transporter SLC6A4 0.0094
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0091
6459 Glycodelin PAEP 0.0091
2298 Cytochrome P450-cam camC 0.0091
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0091
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0089
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0089
3941 Amine oxidase [flavin-containing] A MAOA 0.0088
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0088
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0087
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0086
4952 Catalase/peroxidase katA 0.0086
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0086
740 Argininosuccinate synthase ASS1 0.0086
865 Argininosuccinate synthase ASS1 0.0086
2680 Argininosuccinate synthase argG 0.0086
3194 Argininosuccinate synthase argG 0.0086
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0086
3093 Catalase HPII katE 0.0086
6144 Solute carrier family 22 member 2 SLC22A2 0.0085
816 Biliverdin reductase A BLVRA 0.0085
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0085
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0085
4954 Soluble cytochrome b558 Not Available 0.0085
4916 Cyanoglobin glbN 0.0085
4942 Diheme cytochrome c napB napB 0.0085
4936 Cytochrome c2 iso-2 Not Available 0.0085
4935 Cytochrome c-554 cycA1 0.0085
4984 Neuroglobin NGB 0.0085
4943 Cytochrome c6 petJ 0.0085
4934 Cytochrome c-551 nirM 0.0085
5218 Cytochrome c-551 nirM 0.0085
4905 Cytochrome c2 Not Available 0.0085
4939 Cytochrome c2 cycA 0.0085
4964 Cytochrome c2 cycA 0.0085
4979 Cytochrome c2 cycA 0.0085
6673 Cytochrome c2 cycA 0.0085
4907 Cytochrome c-L moxG 0.0085
6865 Cytochrome c-L moxG 0.0085
4981 Iron-starvation protein PigA pigA 0.0085
4909 CooA protein cooA 0.0085
4994 Hemoglobin-like protein HbO glbO 0.0085
4915 Cytochrome c-550 psbV 0.0085
4959 Cytochrome c-550 psbV 0.0085
5216 Cytochrome c-550 psbV 0.0085
4925 Cytochrome c-type protein SHP shp 0.0085
4998 Hemoglobin-like protein yjbI yjbI 0.0085
4947 Bacterial hemoglobin vhb 0.0085
4975 Cytochrome c-556 RPA3973 0.0085
5000 HemO hemO 0.0085
4937 Cytochrome oxidase subunit II rcoxA 0.0085
4971 Nonaheme cytochrome c hmcA 0.0085
4961 Hemophore HasA hasA 0.0085
4910 Cytoglobin CYGB 0.0085
4976 Apocytochrome f petA 0.0085
6407 Apocytochrome f petA 0.0085
4904 Cytochrome c family protein GSU1996 0.0085
4903 Methyl-accepting chemotaxis protein Tar4 0.0085
4999 Cytochrome P450 165B3 CYP165B3 0.0085
4972 P450cin cinA 0.0085
4764 Cytochrome P450 165C4 CYP165C4 0.0085
4960 Putative cytochrome P450-family protein SCO7417 0.0085
4931 Cytochrome P450 167A1 CYP167A1 0.0085
4989 Cytochrome c551 peroxidase ccp 0.0085
5222 Cytochrome c551 peroxidase ccpA 0.0085
4926 Heme-based aerotactic transducer hemAT hemAT 0.0085
4922 Cytochrome c, putative SO_4144 0.0085
4993 Hydroxylamine oxidoreductase hao1 0.0085
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0085
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0085
4311 tRNA TRDMT1 0.0085
4325 tRNA trmD 0.0085
4328 tRNA trmD 0.0085
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0085
4692 A/G-specific adenine glycosylase mutY 0.0085
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0084
766 Beta-2 adrenergic receptor ADRB2 0.0083
118 Organic cation/carnitine transporter 2 SLC22A5 0.0083
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0082
6031 Cytochrome P450 3A43 CYP3A43 0.0082
341 5-hydroxytryptamine 3 receptor HTR3A 0.0081
569 Retinal dehydrogenase 2 ALDH1A2 0.008
590 5-hydroxytryptamine 2C receptor HTR2C 0.008
2802 Endoglucanase G celCCG 0.008
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.008
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0079
862 Multidrug resistance-associated protein 1 ABCC1 0.0079
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0079
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0079
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0079
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0079
328 Sorbitol dehydrogenase SORD 0.0079
597 Dihydropteridine reductase QDPR 0.0078
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0078
465 Calmodulin CALM1 0.0078
611 Retinal dehydrogenase 1 ALDH1A1 0.0078
6316 ADP-ribosylation factor 1 ARF1 0.0078
6147 Solute carrier family 22 member 3 SLC22A3 0.0078
12 Alcohol dehydrogenase class 3 ADH5 0.0077
3939 Amine oxidase [flavin-containing] B MAOB 0.0076
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0075
136 Estrogen receptor ESR1 0.0075
358 Cystathionine beta-synthase CBS 0.0075
77 L-lactate dehydrogenase B chain LDHB 0.0074
810 Heme oxygenase 1 HMOX1 0.0074
3391 Heme oxygenase 1 pbsA1 0.0074
275 Arachidonate 5-lipoxygenase ALOX5 0.0074
502 5-hydroxytryptamine 2A receptor HTR2A 0.0073
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0072
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0072
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0072
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0072
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0072
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0072
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0072
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0071
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0071
666 NADP-dependent malic enzyme ME1 0.0071
16 Adenosine A1 receptor ADORA1 0.007
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.007
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.0069
904 Glutathione S-transferase P GSTP1 0.0069
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0068
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0068
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0068
2164 Multidrug resistance-associated protein 4 ABCC4 0.0068
4920 Peroxidase/catalase katG 0.0068
556 Alpha-1A adrenergic receptor ADRA1A 0.0068
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0067
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0067
4948 Cytochrome c-553 Not Available 0.0067
4923 Cytochrome c3 DvMF_2499 0.0067
4945 Cytochrome c3 Not Available 0.0067
4949 Cytochrome c3 DVU_3171 0.0067
4968 Cytochrome c3 cytc3 0.0067
4997 Cytochrome c3 SO_2727 0.0067
5219 Cytochrome c3 cyd 0.0067
2119 Cytochrome b5 CYB5A 0.0067
4902 Nine-heme cytochrome c Ddes_2038 0.0067
3189 High-molecular-weight cytochrome c hmcA 0.0067
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0067
4990 PpcA ppcA 0.0067
3375 Acidic cytochrome c3 Not Available 0.0067
4813 Heme oxygenase hmuO 0.0066
5769 Heme oxygenase Not Available 0.0066
4385 Cytochrome c' Not Available 0.0066
4967 Cytochrome c' cycA 0.0066
5038 Cytochrome c' Not Available 0.0066
5223 Cytochrome c' cycP 0.0066
4037 Hypothetical protein GPX1 0.0066
4297 Hypothetical protein SP_1951 0.0066
4521 Hypothetical protein BC_2969 0.0066
4540 Hypothetical protein TM_1070 0.0066
4555 Hypothetical protein MT1739 0.0066
4569 Hypothetical protein mshD 0.0066
4578 Hypothetical protein PA3270 0.0066
4747 Hypothetical protein PA3967 0.0066
5177 Hypothetical protein TM_0096 0.0066
5194 Hypothetical protein PA1204 0.0066
5240 Hypothetical protein Rv2991 0.0066
5370 Hypothetical protein TM_1158 0.0066
5710 Hypothetical protein Tb927.5.1360 0.0066
4992 Cytochrome c peroxidase Not Available 0.0066
4289 Cytochrome P450 TT_P0059 0.0066
6262 Cytochrome P450 staP 0.0066
3570 Cytochrome P450 152A1 cypC 0.0066
4988 Sulfite oxidase, mitochondrial SUOX 0.0066
2915 Sensor protein fixL fixL 0.0066
4944 Sensor protein fixL fixL 0.0066
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0065
831 D(2) dopamine receptor DRD2 0.0065
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0065
891 Dihydropteroate synthase folP 0.0064
5359 Dihydropteroate synthase folP 0.0064
7175 Dihydropteroate synthase sulI 0.0064
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0063
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0063
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0063
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0063
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.0063
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0062
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0062
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0061
6143 Solute carrier family 22 member 7 SLC22A7 0.0061
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0061
3947 Xanthine dehydrogenase/oxidase XDH 0.006
3670 Soluble cytochrome b562 precursor cybC 0.006
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.006
3291 Cytochrome c-552 cycA 0.006
4927 Cytochrome c-552 nrfA 0.006
4938 Cytochrome c-552 cycA 0.006
4953 Cytochrome c-552 nrfA 0.006
5217 Cytochrome c-552 cycM 0.006
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0059
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0059
4386 Hemoglobin-like protein HbN glbN 0.0059
2617 Nitric oxide synthase oxygenase nos 0.0059
2701 Nitric oxide synthase oxygenase nos 0.0059
3102 Flavohemoprotein hmp 0.0059
4969 Flavohemoprotein hmp 0.0059
4238 50S ribosomal protein L4 rplD 0.0059
5578 50S ribosomal protein L4 rplD 0.0059
6173 50S ribosomal protein L4 rplD 0.0059
6219 50S ribosomal protein L4 rplD 0.0059
3809 Estrogen-related receptor gamma ESRRG 0.0059
4497 Benzyl alcohol dehydrogenase xylB 0.0059
4423 Levodione reductase lvr 0.0059
4428 Redox-sensing transcriptional repressor rex rex 0.0059
4500 L-lactate dehydrogenase 2 ldh2 0.0059
4449 ADP-ribosyltransferase Not Available 0.0059
4495 3-oxoacyl-(Acyl carrier protein) reductase TM_1169 0.0059
4435 L-aspartate dehydrogenase nadX 0.0059
4446 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase Not Available 0.0059
3729 Citrate synthase gltA 0.0059
4575 Citrate synthase cit 0.0059
4580 Citrate synthase gltA 0.0059
4505 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase bphB 0.0059
4447 Hypothetical protein yhfP yhfP 0.0059
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.0059
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.0059
4487 Transcriptional regulator nadR nadR 0.0059
3735 NAD(P) transhydrogenase subunit alpha part 1 pntAA 0.0059
4414 Dehydrogenase TT_P0035 0.0059
2350 3-isopropylmalate dehydrogenase leuB 0.0059
3092 3-isopropylmalate dehydrogenase leuB 0.0059
4418 AGR_L_3209p AGR_L_3209 0.0059
4507 Alanine dehydrogenase ald 0.0059
4475 Hypothetical protein Rv0046c/MT0052 ino1 0.0059
4506 Myo-inositol-1-phosphate synthase-related protein TM_1419 0.0059
4448 L-2-hydroxyisocaproate dehydrogenase Not Available 0.0059
4466 Glutathione-independent formaldehyde dehydrogenase fdhA 0.0059
4502 Formate dehydrogenase Not Available 0.0059
4455 Glycerol dehydrogenase gldA 0.0059
4451 Vip2Ac vip2Ac 0.0059
4472 Glucose 1-dehydrogenase Not Available 0.0059
4456 Inorganic polyphosphate/ATP-NAD kinase ppnK 0.0059
4443 Quinate/shikimate dehydrogenase ydiB 0.0059
4467 Alpha-glucosidase, putative TM_0752 0.0059
4471 CDP-D-glucose-4,6-dehydratase ascB 0.0059
365 Dihydrofolate reductase DHFR 0.0058
2381 Dihydrofolate reductase DFR1 0.0058
2833 Dihydrofolate reductase Not Available 0.0058
2931 Dihydrofolate reductase folA 0.0058
3544 Dihydrofolate reductase folA 0.0058
3682 Dihydrofolate reductase folA 0.0058
6642 Dihydrofolate reductase folA 0.0058
6756 Dihydrofolate reductase dfrA 0.0058
76 Nitric-oxide synthase, brain NOS1 0.0057
654 Flavin reductase BLVRB 0.0057
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0057
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0057
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0057
713 Sodium-dependent dopamine transporter SLC6A3 0.0057
6145 Solute carrier family 22 member 1 SLC22A1 0.0057
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0057
7 Nitric oxide synthase, inducible NOS2 0.0056
613 Atrial natriuretic peptide receptor A NPR1 0.0056
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0056
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0056
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0056
714 Glutathione reductase, mitochondrial GSR 0.0055
605 Fumarate reductase flavoprotein subunit frdA 0.0055
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0055
3673 Fumarate reductase flavoprotein subunit fccA 0.0055
4912 Fumarate reductase flavoprotein subunit ifcA 0.0055
6549 Fumarate reductase flavoprotein subunit frdA 0.0055
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0055
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0055
3127 Nitrite reductase nirS 0.0055
3284 Nitrite reductase nirS 0.0055
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0055
2972 6-deoxyerythronolide B hydroxylase eryF 0.0055
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0055
4237 50S ribosomal protein L22 rplV 0.0054
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0054
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0054
380 Cytochrome P450 17A1 CYP17A1 0.0053
4604 Liver carboxylesterase 1 CES1 0.0053
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0053
4608 Putative cytochrome P450 SCO1207 0.0052
4963 Putative cytochrome P450 SCO2884 0.0052
6254 Putative cytochrome P450 SCO6998 0.0052
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0052
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0052
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0051
1181 Alpha-1-acid glycoprotein 1 ORM1 0.005
94 5-hydroxytryptamine 4 receptor HTR4 0.005
80 Peroxisome proliferator-activated receptor alpha PPARA 0.005
450 Muscarinic acetylcholine receptor M4 CHRM4 0.005
23 D(1A) dopamine receptor DRD1 0.005
320 5-hydroxytryptamine 1A receptor HTR1A 0.005
1010 Cytochrome P450 51A1 CYP51A1 0.0049
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0049
3932 Glutathione S-transferase A2 GSTA2 0.0049
1178 Adenosine A2a receptor ADORA2A 0.0048
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0048
563 Thyroid peroxidase TPO 0.0048
1507 Cytochrome c CYCS 0.0048
4427 TDP-glucose-4,6-dehydratase desIV 0.0048
3177 dTDP-glucose 4,6-dehydratase rfbB 0.0048
4499 dTDP-glucose 4,6-dehydratase rmlB 0.0048
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.0048
4486 Phenol 2-hydroxylase component B pheA2 0.0048
4439 Ferredoxin reductase bphA4 0.0048
4477 Dihydrolipoyl dehydrogenase lpdV 0.0048
5077 Dihydrolipoyl dehydrogenase Not Available 0.0048
5117 Dihydrolipoyl dehydrogenase lpd 0.0048
2967 CDP-paratose 2-epimerase rfbE 0.0048
4482 UDP-galactose 4-epimerase galE 0.0048
4503 NADPH-flavin oxidoreductase frp 0.0048
2507 Diphtheria toxin Not Available 0.0048
4509 Acetoin(diacetyl) reductase budC 0.0047
1199 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 ART1 0.0047
3615 Dihydrodipicolinate reductase dapB 0.0047
3618 Dihydrodipicolinate reductase dapB 0.0047
4462 Dihydrodipicolinate reductase dapB 0.0047
2591 Urocanate hydratase hutU 0.0047
2393 Maltose-6'-phosphate glucosidase glvA 0.0047
2538 6-phospho-beta-glucosidase bglT bglT 0.0047
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0047
3081 3-dehydroquinate synthase aroB 0.0047
6698 Dehydrogenase/reductase SDR family member 4-like 2 DHRS4L2 0.0047
126 D-lactate dehydrogenase dld 0.0047
3545 D-lactate dehydrogenase Not Available 0.0047
4510 D-lactate dehydrogenase ldhA 0.0047
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0047
4450 Iota toxin component Ia Not Available 0.0047
2424 L-lactate dehydrogenase ldh 0.0047
2641 L-lactate dehydrogenase Not Available 0.0047
4437 L-lactate dehydrogenase ldh 0.0047
4442 L-lactate dehydrogenase ldh 0.0047
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.0047
3059 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase fabG3 0.0047
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.0047
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0047
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0047
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0047
4496 C-terminal-binding protein 1 CTBP1 0.0047
2881 Gamma-aminobutyraldehyde dehydrogenase prr 0.0047
2018 Deoxyhypusine synthase DHPS 0.0047
2336 2,3-diketo-L-gulonate reductase dlgD 0.0047
4498 Ornithine cyclodeaminase PP3533 0.0047
811 Translocator protein TSPO 0.0047
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0047
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0046
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0046
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0046
693 Hemoglobin subunit beta HBB 0.0046
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0045
6141 Sodium/bile acid cotransporter SLC10A1 0.0045
790 DNA polymerase subunit alpha B POLA2 0.0045
6268 Hydroxyacid oxidase 1 HAO1 0.0045
822 Aldose reductase AKR1B1 0.0045
2683 Mono-ADP-ribosyltransferase C3 C3 0.0045
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0045
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0045
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0044
291 Nitric-oxide synthase, endothelial NOS3 0.0044
6136 Multidrug resistance-associated protein 5 ABCC5 0.0044
3810 Catechol O-methyltransferase COMT 0.0044
3917 Methylenetetrahydrofolate reductase MTHFR 0.0043
4504 WbpP Not Available 0.0043
3296 Nicotinamide mononucleotide adenylyltransferase 1 NMNAT1 0.0043
1192 Sulfotransferase 1A1 SULT1A1 0.0043
885 5-hydroxytryptamine 1B receptor HTR1B 0.0043
3367 GDP-mannose 6-dehydrogenase algD 0.0043
2391 Ferrochelatase hemH 0.0043
6502 Ferrochelatase DKFZp686P18130 0.0043
1591 Ferrochelatase, mitochondrial FECH 0.0043
4440 NADH peroxidase npr 0.0043
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0043
4318 Siroheme synthase cysG 0.0043
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0043
4343 Alpha-glucosidase aglA 0.0042
2799 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Not Available 0.0042
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0042
4476 Mannitol dehydrogenase mtlD 0.0042
63 Malate dehydrogenase mdh 0.0042
2329 Malate dehydrogenase mdh 0.0042
3445 Malate dehydrogenase mdh 0.0042
4420 Malate dehydrogenase mdh 0.0042
4438 Malate dehydrogenase mdh 0.0042
5322 Oxidoreductase ydhF ydhF 0.0042
3772 3-oxoacyl-[acyl-carrier-protein] reductase fabG 0.0042
5326 Oxidoreductase, short chain dehydrogenase/reductase family TM_0441 0.0042
5332 MtdA bifunctional protein mtdA 0.0042
5330 General stress protein 69 yhdN 0.0042
5333 Alcohol dehydrogenase, iron-containing TM_0920 0.0042
5342 NADH-dependent butanol dehydrogenase, putative TM_0820 0.0042
5157 Dehydrogenase/reductase SDR family member 11 DHRS11 0.0042
3778 NAD(P) transhydrogenase subunit beta pntB 0.0042
5346 Oxidoreductase, aldo/keto reductase family TM_1009 0.0042
5343 NADP-dependent fatty aldehyde dehydrogenase aldH 0.0042
4403 Protein iolS iolS 0.0042
817 DNA topoisomerase 2-alpha TOP2A 0.0042
833 Organic cation/carnitine transporter 1 SLC22A4 0.0041
921 Glutamate receptor 2 GRIA2 0.0041
777 Tumor necrosis factor TNF 0.0041
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0041
2826 Glucose--fructose oxidoreductase gfo 0.004
6020 Aldehyde oxidase AOX1 0.004
3333 Nicotinamide mononucleotide adenylyltransferase 3 NMNAT3 0.004
2434 NH(3)-dependent NAD(+) synthetase nadE 0.004
2910 NH(3)-dependent NAD(+) synthetase nadE 0.004
3217 NH(3)-dependent NAD(+) synthetase nadE 0.004
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.004
3070 Adenosylhomocysteinase AHCY 0.004
4424 Adenosylhomocysteinase PFE1050w 0.004
6278 Adenosylhomocysteinase ahcY 0.004
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.004
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.004
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.004
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.004
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.004
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.004
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.004
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.004
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.004
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.004
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.004
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.004
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.004
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.004
602 Acyl carrier protein, mitochondrial NDUFAB1 0.004
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.004
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.004
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.004
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.004
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.004
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.004
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.004
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.004
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.004
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.004
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.004
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.004
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.004
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.004
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.004
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.004
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.004
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.004
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.004
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.004
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.004
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.004
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.004
729 GDP-L-fucose synthetase TSTA3 0.004
3463 GDP-L-fucose synthetase fcl 0.004
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.004
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.004
167 L-lactate dehydrogenase C chain LDHC 0.004
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.004
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.004
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.004
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.004
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.004
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.004
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.004
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.004
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.004
107 C-4 methylsterol oxidase SC4MOL 0.004
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.004
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.004
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.004
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.004
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.004
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.004
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.004
206 3-keto-steroid reductase HSD17B7 0.004
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.004
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.004
662 Fatty aldehyde dehydrogenase ALDH3A2 0.004
711 UDP-glucose 6-dehydrogenase UGDH 0.004
3672 UDP-glucose 6-dehydrogenase hasB 0.004
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.004
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.004
3726 D-3-phosphoglycerate dehydrogenase serA 0.004
4291 D-3-phosphoglycerate dehydrogenase serA 0.004
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.004
644 Heme oxygenase 2 HMOX2 0.004
4982 Heme oxygenase 2 pbsA2 0.004
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.004
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.004
327 Glutathione reductase gor 0.004
5110 Glutathione reductase GR2 0.004
643 Peroxisomal bifunctional enzyme EHHADH 0.004
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.004
34 7-dehydrocholesterol reductase DHCR7 0.004
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.004
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.004
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.004
3823 Cytokine receptor common gamma chain IL2RG 0.0039
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0039
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0039
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0039
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0039
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0039
6142 Solute carrier family 22 member 8 SLC22A8 0.0039
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0038
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0038
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0038
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0038
4164 Potassium voltage-gated channel subfamily KQT member 5 KCNQ5 0.0038
4163 Potassium voltage-gated channel subfamily KQT member 4 KCNQ4 0.0038
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0038
857 Malate dehydrogenase, mitochondrial MDH2 0.0038
871 Glucocorticoid receptor NR3C1 0.0038
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0037
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0037
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0037
6493 Cytochrome c oxidase subunit 6C COX6C 0.0037
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0037
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0037
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0037
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0037
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0037
6558 Cytochrome c oxidase subunit 1 ctaD 0.0037
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0037
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0037
6559 Cytochrome c oxidase subunit 2 ctaC 0.0037
6669 Cytochrome c oxidase subunit 2 ctaC 0.0037
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0037
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0037
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0037
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0037
2375 ADP-L-glycero-D-manno-heptose-6-epimerase hldD 0.0037
869 Estrogen receptor beta ESR2 0.0037
5073 Ferredoxin--NADP reductase petH 0.0037
5076 Ferredoxin--NADP reductase fpr 0.0037
5119 Ferredoxin--NADP reductase petH 0.0037
5121 Ferredoxin--NADP reductase fpr 0.0037
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0037
3446 NADP-dependent alcohol dehydrogenase adh 0.0036
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0036
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0036
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0036
4582 Putative pteridine reductase 2 ptr2 0.0036
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0036
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0036
989 L-xylulose reductase DCXR 0.0036
2636 Shikimate dehydrogenase aroE 0.0036
3515 Shikimate dehydrogenase aroE 0.0036
5328 Prostaglandin F synthase Tb11.02.2310 0.0036
2305 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 0.0036
4491 DNA ligase, NAD-dependent ligA 0.0036
2286 Isocitrate dehydrogenase [NADP] icd 0.0036
2302 Isocitrate dehydrogenase [NADP] icd 0.0036
2771 Isocitrate dehydrogenase [NADP] icd 0.0036
318 Alpha-2A adrenergic receptor ADRA2A 0.0036
1636 Trace amine-associated receptor 1 TAAR1 0.0036
2762 UDP-glucose 4-epimerase GALE 0.0035
3461 UDP-glucose 4-epimerase galE 0.0035
6026 Alcohol dehydrogenase 6 ADH6 0.0035
3587 Gastrotropin FABP6 0.0034
2540 Choloylglycine hydrolase cbh 0.0034
724 Interleukin-2 receptor alpha chain IL2RA 0.0034
717 Interleukin-2 receptor subunit beta IL2RB 0.0034
2178 Metabotropic glutamate receptor 5 GRM5 0.0034
725 5-hydroxytryptamine 1D receptor HTR1D 0.0034
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0033
84 Nuclear receptor 0B1 NR0B1 0.0033
13 Aminomethyltransferase, mitochondrial AMT 0.0033
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0033
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0033
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0033
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0033
4116 Dihydropteroate synthetase Not Available 0.0033
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0033
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0033
627 11-cis retinol dehydrogenase RDH5 0.0033
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0033
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0033
6297 Prostaglandin reductase 1 PTGR1 0.0033
6862 Aldo-keto reductase family 1 member B10 AKR1B10 0.0033
4531 Putative ketoacyl reductase actIII 0.0033
3062 Aspartate-semialdehyde dehydrogenase asd 0.0033
626 Cysteine dioxygenase type 1 CDO1 0.0033
632 Alpha-1B adrenergic receptor ADRA1B 0.0033
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0033
4122 Histone deacetylase 2 HDAC2 0.0033
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0033
3937 Fatty-acid amide hydrolase FAAH 0.0033
400 Coagulation factor IX F9 0.0033
5461 Coagulation factor IX F9 0.0033
6501 Fatty acid-binding protein, liver FABP1 0.0032
716 5-hydroxytryptamine 7 receptor HTR7 0.0032
232 Corticosteroid-binding globulin SERPINA6 0.0032
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0032
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0032
2675 Pteridine reductase 1 PTR1 0.0032
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0032
6766 O-GlcNAcase BT_4395 BT_4395 0.0031
3090 Chitosanase csn 0.0031
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.0031
2159 Quinone oxidoreductase CRYZ 0.0031
1124 Sepiapterin reductase SPR 0.0031
106 Cannabinoid receptor 2 CNR2 0.0031
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0031
6174 50S ribosomal protein L32 rpmF 0.0031
638 D(3) dopamine receptor DRD3 0.003
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.003
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.003
604 Vitamin K-dependent protein Z PROZ 0.003
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0029
68 Cannabinoid receptor 1 CNR1 0.0029
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0029
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0029
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0029
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0029
279 Tyrosinase TYR 0.0029
131 Synaptic vesicular amine transporter SLC18A2 0.0029
153 Dopamine beta-hydroxylase DBH 0.0029
528 5-hydroxytryptamine 1E receptor HTR1E 0.0028
1253 Interferon gamma IFNG 0.0028
330 Spermidine synthase SRM 0.0028
3038 Spermidine synthase speE 0.0028
295 Carbonic anhydrase 1 CA1 0.0028
390 Adenosine A3 receptor ADORA3 0.0028
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0028
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0028
1757 Myeloperoxidase MPO 0.0028
422 Vitamin K-dependent protein C PROC 0.0028
1245 Vitamin K-dependent protein S PROS1 0.0028
436 5-hydroxytryptamine 2B receptor HTR2B 0.0027
3404 Exotoxin A eta 0.0027
373 Transthyretin TTR 0.0027
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0026
6500 Phospholipase A2 PLA2G1B 0.0026
6220 Aryl hydrocarbon receptor AHR 0.0025
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0025
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0025
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0024
789 Alpha-1D adrenergic receptor ADRA1D 0.0024
6126 Carbonic anhydrase 7 CA7 0.0024
334 S-adenosylmethionine synthetase isoform type-2 MAT2A 0.0024
1024 Solute carrier family 22 member 11 SLC22A11 0.0024
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0024
1275 Estrogen sulfotransferase SULT1E1 0.0023
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0023
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0023
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0023
1268 Neuropeptide S receptor NPSR1 0.0023
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0023
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0023
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0023
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0023
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0023
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0023
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0023
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0023
798 Osteocalcin BGLAP 0.0022
1050 Bile salt sulfotransferase SULT2A1 0.0022
113 S-adenosylmethionine decarboxylase proenzyme AMD1 0.0022
411 Glycine N-methyltransferase GNMT 0.0022
2290 ADP-ribosyl cyclase 2 BST1 0.0022
65 Matrix metalloproteinase-9 Not Available 0.0021
432 D(4) dopamine receptor DRD4 0.0021
6432 Transporter snf 0.0021
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0021
4120 NADPH--cytochrome P450 reductase POR 0.0021
6073 Potassium channel subfamily K member 9 KCNK9 0.0021
6072 Potassium channel subfamily K member 3 KCNK3 0.0021
1360 Sphingomyelin phosphodiesterase SMPD1 0.0021
369 Coagulation factor VII F7 0.002
378 Alpha-2C adrenergic receptor ADRA2C 0.002
847 Mu-type opioid receptor OPRM1 0.002
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.002
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.002
592 Carbonic anhydrase 4 CA4 0.002
477 DNA topoisomerase 4 subunit A parC 0.002
886 DNA topoisomerase 4 subunit A parC 0.002
6226 DNA topoisomerase 4 subunit A parC 0.002
4226 Uridine phosphorylase 2 UPP2 0.0019
4217 Telomerase reverse transcriptase TERT 0.0019
718 Folate receptor gamma FOLR3 0.0019
299 Folate receptor beta FOLR2 0.0019
804 Mitochondrial folate transporter/carrier SLC25A32 0.0019
404 DNA gyrase subunit A gyrA 0.0019
6224 DNA gyrase subunit A gyrA 0.0019
723 Cytosolic phospholipase A2 PLA2G4A 0.0019
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0019
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0019
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0019
1256 5-hydroxytryptamine 6 receptor HTR6 0.0019
6138 Multidrug resistance protein 3 ABCB4 0.0019
511 5-hydroxytryptamine 1F receptor HTR1F 0.0019
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0018
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0018
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0018
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0018
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0018
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0018
4225 Uridine phosphorylase 1 UPP1 0.0018
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0017
469 Annexin A1 ANXA1 0.0017
908 Glutathione S-transferase theta-1 GSTT1 0.0017
719 Retinoic acid receptor responder protein 1 RARRES1 0.0017
770 Retinoic acid-induced protein 3 GPRC5A 0.0017
284 DNA-directed RNA polymerase beta chain rpoB 0.0017
5773 DNA-directed RNA polymerase beta chain rpoB 0.0017
823 Fibroblast growth factor receptor 2 FGFR2 0.0017
293 Gamma-glutamyl hydrolase GGH 0.0017
413 Amidophosphoribosyltransferase PPAT 0.0017
2515 Amidophosphoribosyltransferase purF 0.0017
3714 Amidophosphoribosyltransferase purF 0.0017
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0017
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0017
6148 Multidrug resistance-associated protein 7 ABCC10 0.0016
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0016
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0016
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0016
193 Beta-1 adrenergic receptor ADRB1 0.0016
3601 Dihydropteroate synthase 1 folP1 0.0016
3807 Dihydropteroate synthase 1 folP1 0.0016
3808 Dihydropteroate synthase 2 folP2 0.0016
3923 Cholinesterase BCHE 0.0016
844 Epidermal growth factor receptor EGFR 0.0016
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0016
2207 Rhodopsin RHO 0.0016
239 Coagulation factor X F10 0.0015
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0015
2320 Thymidine kinase, cytosolic TK1 0.0015
122 P2Y purinoceptor 12 P2RY12 0.0015
467 Delta-type opioid receptor OPRD1 0.0015
696 Kappa-type opioid receptor OPRK1 0.0015
3913 Glutamic acid decarboxylase GAD65 0.0015
1650 Heme carrier protein 1 SLC46A1 0.0015
357 Carbonic anhydrase 2 CA2 0.0015
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0014
29 Tubulin beta-1 chain TUBB1 0.0014
161 Tubulin beta chain TUBB 0.0014
312 Tubulin beta chain TUB2 0.0014
1483 Membrane copper amine oxidase AOC3 0.0014
319 Opioid receptor, sigma 1 OPRS1 0.0014
3639 Thymidine phosphorylase deoA 0.0014
3936 Thymidine phosphorylase TYMP 0.0014
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0014
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0014
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0013
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0013
5934 Cytochrome P450 26A1 CYP26A1 0.0013
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0013
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0013
976 Platelet glycoprotein IX GP9 0.0013
629 Alpha-2B adrenergic receptor ADRA2B 0.0013
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0013
1039 Histone deacetylase 9 HDAC9 0.0013
164 Histamine H4 receptor HRH4 0.0013
1374 Natriuretic peptides B NPPB 0.0013
1827 Gap junction alpha-1 protein GJA1 0.0013
1908 Vascular cell adhesion protein 1 VCAM1 0.0013
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0013
54 Prothrombin F2 0.0013
814 Ryanodine receptor 1 RYR1 0.0012
735 Alanine aminotransferase 1 GPT 0.0012
3904 Alanine aminotransferase 2 GPT2 0.0012
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0012
780 Retinoic acid receptor RXR-gamma RXRG 0.0012
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0012
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0012
174 Sigma 1-type opioid receptor SIGMAR1 0.0012
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0011
24 Thymidylate synthase TMP1 0.0011
359 Thymidylate synthase TYMS 0.0011
2626 Thymidylate synthase thyA 0.0011
2729 Thymidylate synthase thyA 0.0011
5352 Thymidylate synthase THYA 0.0011
88 Retinoic acid receptor RXR-beta RXRB 0.0011
268 Adenosine A2b receptor ADORA2B 0.0011
162 Retinoic acid receptor gamma-1 RARG 0.0011
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.001
6131 Carbonic anhydrase 14 CA14 0.001
183 Vascular endothelial growth factor A VEGFA 0.001
737 Mineralocorticoid receptor NR3C2 0.001
6163 Copper-transporting ATPase 2 ATP7B 0.001
6165 Copper-transporting ATPase 1 ATP7A 0.001
997 Protein kinase C beta type PRKCB 0.0009
6122 Carbonic anhydrase 3 CA3 0.0009
6146 High affinity copper uptake protein 1 SLC31A1 0.0009
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0009
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0009
634 Squalene monooxygenase SQLE 0.0009
7196 Squalene monooxygenase ERG1 0.0009
614 Progesterone receptor PGR 0.0009
4192 DNA topoisomerase 2-beta TOP2B 0.0009
1970 Protein kinase C alpha type PRKCA 0.0009
2408 Tyrosine-protein kinase SYK SYK 0.0009
3007 Carbonic anhydrase 12 CA12 0.0009
4205 Carbonic anhydrase 9 CA9 0.0009
751 Potassium channel subfamily K member 6 KCNK6 0.0008
731 HIV-1 protease HIV-1 protease 0.0008
896 Glutathione S-transferase Mu 1 GSTM1 0.0008
172 Potassium channel subfamily K member 1 KCNK1 0.0008
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0008
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0008
6137 Multidrug resistance-associated protein 6 ABCC6 0.0008
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0007
738 Monocarboxylate transporter 1 SLC16A1 0.0007
3957 Adenosine deaminase ADA 0.0007
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0007
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0007
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0007
2236 Casein kinase II subunit alpha CSNK2A1 0.0007
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0006
163 D(1B) dopamine receptor DRD5 0.0006
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0006
1618 High affinity nerve growth factor receptor NTRK1 0.0006
124 Histamine H2 receptor HRH2 0.0006
2981 Phospholipase A2, membrane associated PLA2G2A 0.0005
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0005
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