DT-Web

DB03612 - 3-Hydroxybutyryl-Coenzyme A


Identification
Name 3-Hydroxybutyryl-Coenzyme A
Accession Number DB03612 (EXPT00172)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 853.623
Groups experimental
Monoisotopic Weight 853.151987801
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
Name Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial
Gene Name HADH
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.5507

Predictions


Id Partner name Gene Name Score
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0662
4574 PROBABLE NAPHTHOATE SYNTHASE MENB menB 0.0661
4601 HMG-CoA synthase mvaS 0.0643
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0626
4589 3-hydroxy-3-methylglutaryl CoA synthase mvaS 0.061
2596 Acetyl-CoA acetyltransferase phbA 0.0482
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0064
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0064
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0064
816 Biliverdin reductase A BLVRA 0.0064
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0059
646 Malate dehydrogenase, cytoplasmic MDH1 0.0059
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0059
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0059
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0059
328 Sorbitol dehydrogenase SORD 0.0058
597 Dihydropteridine reductase QDPR 0.0058
396 Alcohol dehydrogenase 4 ADH4 0.0058
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0058
77 L-lactate dehydrogenase B chain LDHB 0.0054
12 Alcohol dehydrogenase class 3 ADH5 0.0054
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0054
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0053
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0053
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0053
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0053
473 L-lactate dehydrogenase A chain LDHA 0.0052
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0052
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.005
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0049
569 Retinal dehydrogenase 2 ALDH1A2 0.0048
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0047
611 Retinal dehydrogenase 1 ALDH1A1 0.0047
251 Alcohol dehydrogenase 1A ADH1A 0.0046
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0045
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0044
444 Alcohol dehydrogenase 1B ADH1B 0.0043
714 Glutathione reductase, mitochondrial GSR 0.004
4449 ADP-ribosyltransferase Not Available 0.004
4471 CDP-D-glucose-4,6-dehydratase ascB 0.004
4495 3-oxoacyl-(Acyl carrier protein) reductase TM_1169 0.004
4435 L-aspartate dehydrogenase nadX 0.004
4466 Glutathione-independent formaldehyde dehydrogenase fdhA 0.004
4446 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase Not Available 0.004
4472 Glucose 1-dehydrogenase Not Available 0.004
4423 Levodione reductase lvr 0.004
4505 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase bphB 0.004
4455 Glycerol dehydrogenase gldA 0.004
4443 Quinate/shikimate dehydrogenase ydiB 0.004
4456 Inorganic polyphosphate/ATP-NAD kinase ppnK 0.004
4448 L-2-hydroxyisocaproate dehydrogenase Not Available 0.004
4447 Hypothetical protein yhfP yhfP 0.004
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.004
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.004
3381 Alcohol dehydrogenase Not Available 0.004
4508 Alcohol dehydrogenase adhA 0.004
4414 Dehydrogenase TT_P0035 0.004
2350 3-isopropylmalate dehydrogenase leuB 0.004
3092 3-isopropylmalate dehydrogenase leuB 0.004
4507 Alanine dehydrogenase ald 0.004
4475 Hypothetical protein Rv0046c/MT0052 ino1 0.004
4428 Redox-sensing transcriptional repressor rex rex 0.004
3735 NAD(P) transhydrogenase subunit alpha part 1 pntAA 0.004
4502 Formate dehydrogenase Not Available 0.004
4487 Transcriptional regulator nadR nadR 0.004
3729 Citrate synthase gltA 0.004
4575 Citrate synthase cit 0.004
4580 Citrate synthase gltA 0.004
4451 Vip2Ac vip2Ac 0.004
4467 Alpha-glucosidase, putative TM_0752 0.004
4500 L-lactate dehydrogenase 2 ldh2 0.004
4418 AGR_L_3209p AGR_L_3209 0.004
4497 Benzyl alcohol dehydrogenase xylB 0.004
4506 Myo-inositol-1-phosphate synthase-related protein TM_1419 0.004
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0039
517 Alcohol dehydrogenase 1C ADH1C 0.0038
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0034
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0034
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0034
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0034
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0034
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0034
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0034
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0034
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0034
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0034
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0034
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0034
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0034
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0034
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0034
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0034
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0034
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0034
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0034
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0034
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0034
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0034
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0034
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0034
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0034
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0034
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0034
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0034
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0034
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0034
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0034
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0034
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0034
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0034
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0034
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0034
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0034
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0034
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0034
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0034
107 C-4 methylsterol oxidase SC4MOL 0.0034
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0034
644 Heme oxygenase 2 HMOX2 0.0034
4982 Heme oxygenase 2 pbsA2 0.0034
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0034
729 GDP-L-fucose synthetase TSTA3 0.0034
3463 GDP-L-fucose synthetase fcl 0.0034
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0034
167 L-lactate dehydrogenase C chain LDHC 0.0034
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0034
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0034
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0034
206 3-keto-steroid reductase HSD17B7 0.0034
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0034
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0034
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0034
643 Peroxisomal bifunctional enzyme EHHADH 0.0034
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0034
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0034
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0034
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0034
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0034
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0034
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0034
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0034
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0034
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0034
711 UDP-glucose 6-dehydrogenase UGDH 0.0034
3672 UDP-glucose 6-dehydrogenase hasB 0.0034
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0034
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0034
3726 D-3-phosphoglycerate dehydrogenase serA 0.0034
4291 D-3-phosphoglycerate dehydrogenase serA 0.0034
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0034
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0034
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0034
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0034
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0034
34 7-dehydrocholesterol reductase DHCR7 0.0034
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0034
4486 Phenol 2-hydroxylase component B pheA2 0.0034
4439 Ferredoxin reductase bphA4 0.0034
4477 Dihydrolipoyl dehydrogenase lpdV 0.0034
5077 Dihydrolipoyl dehydrogenase Not Available 0.0034
5117 Dihydrolipoyl dehydrogenase lpd 0.0034
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.0034
4427 TDP-glucose-4,6-dehydratase desIV 0.0034
3177 dTDP-glucose 4,6-dehydratase rfbB 0.0034
4499 dTDP-glucose 4,6-dehydratase rmlB 0.0034
2967 CDP-paratose 2-epimerase rfbE 0.0033
4482 UDP-galactose 4-epimerase galE 0.0033
4503 NADPH-flavin oxidoreductase frp 0.0033
2507 Diphtheria toxin Not Available 0.0033
2538 6-phospho-beta-glucosidase bglT bglT 0.0033
2393 Maltose-6'-phosphate glucosidase glvA 0.0033
4509 Acetoin(diacetyl) reductase budC 0.0033
3081 3-dehydroquinate synthase aroB 0.0033
2591 Urocanate hydratase hutU 0.0033
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0033
3615 Dihydrodipicolinate reductase dapB 0.0033
3618 Dihydrodipicolinate reductase dapB 0.0033
4462 Dihydrodipicolinate reductase dapB 0.0033
1199 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 ART1 0.0033
4450 Iota toxin component Ia Not Available 0.0033
2424 L-lactate dehydrogenase ldh 0.0033
2641 L-lactate dehydrogenase Not Available 0.0033
4437 L-lactate dehydrogenase ldh 0.0033
4442 L-lactate dehydrogenase ldh 0.0033
6698 Dehydrogenase/reductase SDR family member 4-like 2 DHRS4L2 0.0033
126 D-lactate dehydrogenase dld 0.0033
3545 D-lactate dehydrogenase Not Available 0.0033
4510 D-lactate dehydrogenase ldhA 0.0033
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.0033
3059 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase fabG3 0.0033
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.0033
2336 2,3-diketo-L-gulonate reductase dlgD 0.0033
4498 Ornithine cyclodeaminase PP3533 0.0033
2018 Deoxyhypusine synthase DHPS 0.0033
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0033
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0033
4496 C-terminal-binding protein 1 CTBP1 0.0033
2881 Gamma-aminobutyraldehyde dehydrogenase prr 0.0033
4504 WbpP Not Available 0.0031
2683 Mono-ADP-ribosyltransferase C3 C3 0.0031
3296 Nicotinamide mononucleotide adenylyltransferase 1 NMNAT1 0.0031
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0031
666 NADP-dependent malic enzyme ME1 0.0031
3367 GDP-mannose 6-dehydrogenase algD 0.003
4440 NADH peroxidase npr 0.003
4318 Siroheme synthase cysG 0.003
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.003
4343 Alpha-glucosidase aglA 0.003
2799 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Not Available 0.003
857 Malate dehydrogenase, mitochondrial MDH2 0.003
63 Malate dehydrogenase mdh 0.0029
2329 Malate dehydrogenase mdh 0.0029
3445 Malate dehydrogenase mdh 0.0029
4420 Malate dehydrogenase mdh 0.0029
4438 Malate dehydrogenase mdh 0.0029
4476 Mannitol dehydrogenase mtlD 0.0029
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0029
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0029
3333 Nicotinamide mononucleotide adenylyltransferase 3 NMNAT3 0.0029
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0029
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0029
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0029
2617 Nitric oxide synthase oxygenase nos 0.0029
2701 Nitric oxide synthase oxygenase nos 0.0029
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0028
2826 Glucose--fructose oxidoreductase gfo 0.0028
3070 Adenosylhomocysteinase AHCY 0.0028
4424 Adenosylhomocysteinase PFE1050w 0.0028
6278 Adenosylhomocysteinase ahcY 0.0028
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0028
327 Glutathione reductase gor 0.0028
5110 Glutathione reductase GR2 0.0028
3191 Histidinol dehydrogenase hisD 0.0028
6026 Alcohol dehydrogenase 6 ADH6 0.0027
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0027
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0027
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0027
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0026
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0026
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0026
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0026
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0026
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0026
627 11-cis retinol dehydrogenase RDH5 0.0026
626 Cysteine dioxygenase type 1 CDO1 0.0026
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0026
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0026
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0026
2286 Isocitrate dehydrogenase [NADP] icd 0.0026
2302 Isocitrate dehydrogenase [NADP] icd 0.0026
2771 Isocitrate dehydrogenase [NADP] icd 0.0026
4491 DNA ligase, NAD-dependent ligA 0.0026
13 Aminomethyltransferase, mitochondrial AMT 0.0026
2762 UDP-glucose 4-epimerase GALE 0.0025
3461 UDP-glucose 4-epimerase galE 0.0025
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0025
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0025
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0024
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0024
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0023
654 Flavin reductase BLVRB 0.0023
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0022
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0022
279 Tyrosinase TYR 0.0021
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0021
810 Heme oxygenase 1 HMOX1 0.0021
3391 Heme oxygenase 1 pbsA1 0.0021
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0021
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0021
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0021
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0021
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0021
380 Cytochrome P450 17A1 CYP17A1 0.002
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.002
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0019
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0019
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0018
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0018
822 Aldose reductase AKR1B1 0.0017
468 Cytochrome P450 4A11 CYP4A11 0.0017
6020 Aldehyde oxidase AOX1 0.0017
365 Dihydrofolate reductase DHFR 0.0017
2381 Dihydrofolate reductase DFR1 0.0017
2833 Dihydrofolate reductase Not Available 0.0017
2931 Dihydrofolate reductase folA 0.0017
3544 Dihydrofolate reductase folA 0.0017
3682 Dihydrofolate reductase folA 0.0017
6642 Dihydrofolate reductase folA 0.0017
6756 Dihydrofolate reductase dfrA 0.0017
3947 Xanthine dehydrogenase/oxidase XDH 0.0016
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