DT-Web

DB01861 - Glucose-Uridine-C1,5'-Diphosphate


Identification
Name Glucose-Uridine-C1,5'-Diphosphate
Accession Number DB01861 (EXPT01669)
Type small molecule
Description A key intermediate in carbohydrate metabolism. Serves as a precursor of glycogen, can be metabolized into UDPgalactose and UDPglucuronic acid which can then be incorporated into polysaccharides as galactose and glucuronic acid. Also serves as a precursor of sucrose lipopolysaccharides, and glycosphingolipids. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 566.3018
Groups experimental
Monoisotopic Weight 566.055020376
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Galactose-1-phosphate uridylyltransferase
Name Galactose-1-phosphate uridylyltransferase
Gene Name galT
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.5997
UDP-glucose 4-epimerase
Name UDP-glucose 4-epimerase
Gene Name GALE
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.9083

Predictions


Id Partner name Gene Name Score
3461 UDP-glucose 4-epimerase galE 0.9083
237 Histo-blood group ABO system transferase ABO 0.1428
287 Beta-1,4-galactosyltransferase 1 B4GALT1 0.1258
2612 UDP-N-acetylhexosamine pyrophosphorylase UAP1 0.1042
3524 DNA beta-glucosyltransferase bgt 0.1034
2608 UDP-N-acetylglucosamine 2-epimerase wecB 0.1034
4504 WbpP Not Available 0.0982
2439 Alpha,alpha-trehalose-phosphate synthase [UDP-forming] otsA 0.09
3529 Interferon-stimulated gene 20 kDa protein ISG20 0.0708
3575 Uracil phosphoribosyltransferase upp 0.0708
3600 Uracil phosphoribosyltransferase upp 0.0708
3056 Orotidine 5'-phosphate decarboxylase pyrF 0.0707
3564 Orotidine 5'-phosphate decarboxylase pyrF 0.0707
2344 Ribosomal small subunit pseudouridine synthase A rsuA 0.0616
3706 Ribosomal small subunit pseudouridine synthase A rsuA 0.0616
3257 Bifunctional polymyxin resistance protein arnA arnA 0.0615
2651 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase murG 0.0599
520 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0598
2306 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0598
2367 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0598
5252 Bifunctional protein glmU glmU 0.0598
6789 Bifunctional protein glmU glmU 0.0598
3523 Spore coat polysaccharide biosynthesis protein spsA spsA 0.059
2966 PyrR bifunctional protein [Includes: Pyrimidine operon regulatory protein; Uracil phosphoribosyltransferase pyrR 0.0568
4482 UDP-galactose 4-epimerase galE 0.0535
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0521
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0521
3408 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3 B3GAT3 0.0513
2291 Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1 B3GAT1 0.0513
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.048
24 Thymidylate synthase TMP1 0.0433
359 Thymidylate synthase TYMS 0.0433
2626 Thymidylate synthase thyA 0.0433
2729 Thymidylate synthase thyA 0.0433
5352 Thymidylate synthase THYA 0.0433
2555 Pol polyprotein pol 0.0412
3242 Pol polyprotein gag-pol 0.0412
3471 Pol polyprotein gag-pro-pol 0.0412
5256 Pol polyprotein pol 0.0412
6469 Pol polyprotein gag-pol 0.0412
6565 Pol polyprotein Not Available 0.0412
702 UMP-CMP kinase CMPK1 0.0374
4447 Hypothetical protein yhfP yhfP 0.0025
4449 ADP-ribosyltransferase Not Available 0.0025
4505 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase bphB 0.0025
3381 Alcohol dehydrogenase Not Available 0.0025
4508 Alcohol dehydrogenase adhA 0.0025
4495 3-oxoacyl-(Acyl carrier protein) reductase TM_1169 0.0025
4435 L-aspartate dehydrogenase nadX 0.0025
4446 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase Not Available 0.0025
4472 Glucose 1-dehydrogenase Not Available 0.0025
4423 Levodione reductase lvr 0.0025
4428 Redox-sensing transcriptional repressor rex rex 0.0025
4497 Benzyl alcohol dehydrogenase xylB 0.0025
4443 Quinate/shikimate dehydrogenase ydiB 0.0025
4456 Inorganic polyphosphate/ATP-NAD kinase ppnK 0.0025
4448 L-2-hydroxyisocaproate dehydrogenase Not Available 0.0025
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.0025
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.0025
4414 Dehydrogenase TT_P0035 0.0025
2350 3-isopropylmalate dehydrogenase leuB 0.0025
3092 3-isopropylmalate dehydrogenase leuB 0.0025
4471 CDP-D-glucose-4,6-dehydratase ascB 0.0025
4418 AGR_L_3209p AGR_L_3209 0.0025
4507 Alanine dehydrogenase ald 0.0025
4475 Hypothetical protein Rv0046c/MT0052 ino1 0.0025
4455 Glycerol dehydrogenase gldA 0.0025
4506 Myo-inositol-1-phosphate synthase-related protein TM_1419 0.0025
3735 NAD(P) transhydrogenase subunit alpha part 1 pntAA 0.0025
4466 Glutathione-independent formaldehyde dehydrogenase fdhA 0.0025
4502 Formate dehydrogenase Not Available 0.0025
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0025
3726 D-3-phosphoglycerate dehydrogenase serA 0.0025
4291 D-3-phosphoglycerate dehydrogenase serA 0.0025
4487 Transcriptional regulator nadR nadR 0.0025
4451 Vip2Ac vip2Ac 0.0025
4467 Alpha-glucosidase, putative TM_0752 0.0025
4500 L-lactate dehydrogenase 2 ldh2 0.0025
3729 Citrate synthase gltA 0.0025
4575 Citrate synthase cit 0.0025
4580 Citrate synthase gltA 0.0025
4427 TDP-glucose-4,6-dehydratase desIV 0.0022
3177 dTDP-glucose 4,6-dehydratase rfbB 0.0022
4499 dTDP-glucose 4,6-dehydratase rmlB 0.0022
6698 Dehydrogenase/reductase SDR family member 4-like 2 DHRS4L2 0.0022
4486 Phenol 2-hydroxylase component B pheA2 0.0022
4509 Acetoin(diacetyl) reductase budC 0.0022
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0022
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0022
3615 Dihydrodipicolinate reductase dapB 0.0022
3618 Dihydrodipicolinate reductase dapB 0.0022
4462 Dihydrodipicolinate reductase dapB 0.0022
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.0022
3059 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase fabG3 0.0022
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0022
4439 Ferredoxin reductase bphA4 0.0022
4477 Dihydrolipoyl dehydrogenase lpdV 0.0022
5077 Dihydrolipoyl dehydrogenase Not Available 0.0022
5117 Dihydrolipoyl dehydrogenase lpd 0.0022
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.0022
1199 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 ART1 0.0022
2336 2,3-diketo-L-gulonate reductase dlgD 0.0022
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.0022
126 D-lactate dehydrogenase dld 0.0022
3545 D-lactate dehydrogenase Not Available 0.0022
4510 D-lactate dehydrogenase ldhA 0.0022
2967 CDP-paratose 2-epimerase rfbE 0.0022
4498 Ornithine cyclodeaminase PP3533 0.0022
2018 Deoxyhypusine synthase DHPS 0.0022
2424 L-lactate dehydrogenase ldh 0.0022
2641 L-lactate dehydrogenase Not Available 0.0022
4437 L-lactate dehydrogenase ldh 0.0022
4442 L-lactate dehydrogenase ldh 0.0022
2538 6-phospho-beta-glucosidase bglT bglT 0.0022
4503 NADPH-flavin oxidoreductase frp 0.0022
4496 C-terminal-binding protein 1 CTBP1 0.0022
2393 Maltose-6'-phosphate glucosidase glvA 0.0022
2881 Gamma-aminobutyraldehyde dehydrogenase prr 0.0022
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0022
2591 Urocanate hydratase hutU 0.0022
2507 Diphtheria toxin Not Available 0.0022
3081 3-dehydroquinate synthase aroB 0.0022
4450 Iota toxin component Ia Not Available 0.0022
2683 Mono-ADP-ribosyltransferase C3 C3 0.002
3296 Nicotinamide mononucleotide adenylyltransferase 1 NMNAT1 0.002
4318 Siroheme synthase cysG 0.002
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.002
2799 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Not Available 0.002
711 UDP-glucose 6-dehydrogenase UGDH 0.002
3672 UDP-glucose 6-dehydrogenase hasB 0.002
3367 GDP-mannose 6-dehydrogenase algD 0.002
4440 NADH peroxidase npr 0.002
4343 Alpha-glucosidase aglA 0.002
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.002
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.002
816 Biliverdin reductase A BLVRA 0.002
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.002
2826 Glucose--fructose oxidoreductase gfo 0.0019
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0019
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0019
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0019
2617 Nitric oxide synthase oxygenase nos 0.0019
2701 Nitric oxide synthase oxygenase nos 0.0019
3070 Adenosylhomocysteinase AHCY 0.0019
4424 Adenosylhomocysteinase PFE1050w 0.0019
6278 Adenosylhomocysteinase ahcY 0.0019
3191 Histidinol dehydrogenase hisD 0.0019
3333 Nicotinamide mononucleotide adenylyltransferase 3 NMNAT3 0.0019
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0019
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0019
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0019
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0019
646 Malate dehydrogenase, cytoplasmic MDH1 0.0019
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0019
597 Dihydropteridine reductase QDPR 0.0019
328 Sorbitol dehydrogenase SORD 0.0019
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0019
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0019
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0019
396 Alcohol dehydrogenase 4 ADH4 0.0019
4476 Mannitol dehydrogenase mtlD 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0018
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0018
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0018
63 Malate dehydrogenase mdh 0.0018
2329 Malate dehydrogenase mdh 0.0018
3445 Malate dehydrogenase mdh 0.0018
4420 Malate dehydrogenase mdh 0.0018
4438 Malate dehydrogenase mdh 0.0018
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0018
77 L-lactate dehydrogenase B chain LDHB 0.0018
12 Alcohol dehydrogenase class 3 ADH5 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
2286 Isocitrate dehydrogenase [NADP] icd 0.0018
2302 Isocitrate dehydrogenase [NADP] icd 0.0018
2771 Isocitrate dehydrogenase [NADP] icd 0.0018
4491 DNA ligase, NAD-dependent ligA 0.0018
473 L-lactate dehydrogenase A chain LDHA 0.0018
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0018
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0018
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0018
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0018
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0018
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0017
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0017
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0016
251 Alcohol dehydrogenase 1A ADH1A 0.0015
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0015
611 Retinal dehydrogenase 1 ALDH1A1 0.0015
569 Retinal dehydrogenase 2 ALDH1A2 0.0015
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0015
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0015
444 Alcohol dehydrogenase 1B ADH1B 0.0015
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0014
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0014
714 Glutathione reductase, mitochondrial GSR 0.0014
517 Alcohol dehydrogenase 1C ADH1C 0.0013
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0013
↑