DT-Web

DB01708 - Dehydroepiandrosterone


Identification
Name Dehydroepiandrosterone
Accession Number DB01708 (DB06593, EXPT00519)
Type small molecule
Description Dehydroepiandrosterone (DHEA) is a major C19 steroid produced by the adrenal cortex. It is also produced in small quantities in the testis and the ovary. Dehydroepiandrosterone (DHEA) can be converted to testosterone; androstenedione; estradiol; and estrone. Most of DHEA is sulfated (dehydroepiandrosterone sulfate) before secretion. In the United States, DHEA or DHEAS have been advertised with claims that they may be beneficial for a wide variety of ailments. DHEA and DHEAS are readily available in the United States, where they are marketed as over-the-counter dietary supplements. In Canada, a prescription is required to buy DHEA.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 288.4244
Groups nutraceutical
Monoisotopic Weight 288.20893014
Pharmacology
Indication DHEA is taken as a supplement for a variety of unsubstantiated indications. The following indications have shown promise and are backed up by some scientific evidence: schizophrenia (DHEA may be more effective in women than men); improving the appearance of older people's skin (taking DHEA by mouth seems to increase skin thickness and moisture, and decrease facial "age spots" in elderly men and women); improving ability to achieve an erection in men with sexual dysfunction. Additionally, DHEA has shown promise in improving symptoms of lupus (SLE). Taking DHEA by mouth along with conventional treatment may help reduce the number of times symptoms flare up and may allow a reduction in the dose of prescription drugs needed. DHEA may also help SLE symptoms such as muscle ache and mouth ulcers. DHEA also seems to strengthen bones in SLE patients being treated with high-dose steroids (corticosteroids). DHEA also shows promise in the treatment of osteoporosis. Taking DHEA by mouth daily seems to improve bone mineral density (BMD) in older women and men with osteoporosis or osteopenia (pre-osteoporosis). DHEA may also increase BMD in young women with the eating disorder called anorexia nervosa. DHEA is often prescribed in India for the induction of ovulation to improve chances of pregnancy.
Mechanism of action DHEA can be understood as a prohormone for the sex steroids. DHEAS may be viewed as buffer and reservoir. As most DHEA is produced by the zona reticularis of the adrenal cortex, it is argued that there is a role in the immune and stress response. As almost all DHEA is derived from the adrenal glands, blood measurements of DHEAS/DHEA are useful to detect excess adrenal activity as seen in adrenal cancer or hyperplasia, including certain forms of congenital adrenal hyperplasia. Women with polycystic ovary syndrome tend to have elevated levels of DHEAS.
Absorption Following a 50-mg DHEA PO dose in cynomolgus monkeys, systemic availability was only 3.1 +/- 0.4%. [PMID: 12970301]
Protein binding Not Available
Biotransformation Hepatic. As shown by their high conversion ratios (in a study involving cynomolgus monkeys), the major circulating metabolites of DHEA are DHEA-S, androsterone glucuronide, and androstane-3 alpha,17 beta-diol-glucuronide. [PMID: 12970301]
Route of elimination Not Available
Toxicity Acute oral toxicity (LD50): >10000 mg/kg [Rat]. Lowest Published Toxic Dose (TDL) [Man] - Route: Oral; Dose: 10 mg/kg/2W intermittent.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Steroid Delta-isomerase
Name Steroid Delta-isomerase
Gene Name ksi
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.7665
Bile salt sulfotransferase
Name Bile salt sulfotransferase
Gene Name SULT2A1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.7744
Cholesterol oxidase
Name Cholesterol oxidase
Gene Name choB
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.3975
Estradiol 17-beta-dehydrogenase 1
Name Estradiol 17-beta-dehydrogenase 1
Gene Name HSD17B1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.8295
Sulfotransferase family cytosolic 2B member 1
Name Sulfotransferase family cytosolic 2B member 1
Gene Name SULT2B1
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.9992

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4163
Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2641

Predictions


Id Partner name Gene Name Score
2920 Steroid Delta-isomerase ksi 0.7665
2822 Cholesterol oxidase choA 0.3975
4118 Cytochrome P450 3A5 CYP3A5 0.1502
4119 Cytochrome P450 2D6 CYP2D6 0.1151
3497 Ribonuclease PH rph 0.1124
5214 Phosphoprotein P/V 0.1124
1588 Multidrug resistance protein 1 ABCB1 0.1053
4824 Dehydrogenase/reductase SDR family member 8 HSD17B11 0.0948
3444 Cyanovirin-N Not Available 0.0904
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0885
6559 Cytochrome c oxidase subunit 2 ctaC 0.0885
6669 Cytochrome c oxidase subunit 2 ctaC 0.0885
6557 Lactaldehyde dehydrogenase aldA 0.0884
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0884
6558 Cytochrome c oxidase subunit 1 ctaD 0.0884
4382 Sulfotransferase family cytosolic 1B member 1 SULT1B1 0.0858
3317 Holo-[acyl-carrier-protein] synthase acpS 0.0855
4381 Holo-[acyl-carrier-protein] synthase acpS 0.0855
4380 Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 NDST1 0.0854
3127 Nitrite reductase nirS 0.0852
3284 Nitrite reductase nirS 0.0852
4757 Cytochrome P450 2C9 CYP2C9 0.0831
4924 Cytochrome P450 2C8 CYP2C8 0.0813
4990 PpcA ppcA 0.0773
6016 Cytochrome P450 2C19 CYP2C19 0.0743
4200 Cytochrome P450 1A2 CYP1A2 0.0729
2540 Choloylglycine hydrolase cbh 0.071
3307 Acriflavine resistance protein B acrB 0.071
6556 Elongation factor Tu GTP-binding domain-containing protein 1 EFTUD1 0.071
2390 Nonsecretory ribonuclease RNASE2 0.0693
1192 Sulfotransferase 1A1 SULT1A1 0.0674
1275 Estrogen sulfotransferase SULT1E1 0.0662
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.0619
6307 Ig gamma-2 chain C region IGHG2 0.0605
380 Cytochrome P450 17A1 CYP17A1 0.0524
2972 6-deoxyerythronolide B hydroxylase eryF 0.0493
6030 Cytochrome P450 2B6 CYP2B6 0.0475
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0457
6013 Cytochrome P450 2E1 CYP2E1 0.0444
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0429
5682 Ribonuclease pancreatic RNASE1 0.0428
587 Serum albumin ALB 0.0368
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0354
862 Multidrug resistance-associated protein 1 ABCC1 0.0338
6024 Cytochrome P450 1A1 CYP1A1 0.0334
3811 Cytochrome P450 19A1 CYP19A1 0.0329
5718 Cytochrome P450 2A6 CYP2A6 0.03
756 Sex hormone-binding globulin SHBG 0.0273
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0245
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0229
847 Mu-type opioid receptor OPRM1 0.0221
20 Prostaglandin G/H synthase 1 PTGS1 0.0218
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0209
871 Glucocorticoid receptor NR3C1 0.0206
146 Androgen receptor AR 0.0199
492 Histamine H1 receptor HRH1 0.0188
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0184
1729 Solute carrier family 22 member 6 SLC22A6 0.018
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0176
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0173
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0172
6106 Cytochrome P450 2C18 CYP2C18 0.0169
6031 Cytochrome P450 3A43 CYP3A43 0.0166
320 5-hydroxytryptamine 1A receptor HTR1A 0.0148
467 Delta-type opioid receptor OPRD1 0.0148
824 Sodium-dependent serotonin transporter SLC6A4 0.0148
5073 Ferredoxin--NADP reductase petH 0.0146
5076 Ferredoxin--NADP reductase fpr 0.0146
5119 Ferredoxin--NADP reductase petH 0.0146
5121 Ferredoxin--NADP reductase fpr 0.0146
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0146
6145 Solute carrier family 22 member 1 SLC22A1 0.0143
502 5-hydroxytryptamine 2A receptor HTR2A 0.0137
831 D(2) dopamine receptor DRD2 0.0137
6102 Arylamine N-acetyltransferase 2 NAT2 0.0132
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0131
556 Alpha-1A adrenergic receptor ADRA1A 0.0131
290 Prostaglandin G/H synthase 2 PTGS2 0.013
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0127
731 HIV-1 protease HIV-1 protease 0.0126
696 Kappa-type opioid receptor OPRK1 0.0125
776 Bile salt export pump ABCB11 0.0124
4439 Ferredoxin reductase bphA4 0.0123
4486 Phenol 2-hydroxylase component B pheA2 0.0123
4477 Dihydrolipoyl dehydrogenase lpdV 0.0123
5077 Dihydrolipoyl dehydrogenase Not Available 0.0123
5117 Dihydrolipoyl dehydrogenase lpd 0.0123
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0122
3763 5,10-methylenetetrahydrofolate reductase metF 0.0122
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0122
5094 5,10-methylenetetrahydrofolate reductase metF 0.0122
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0122
526 Thioredoxin reductase trxB 0.0122
3767 Thioredoxin reductase trxB 0.0122
5078 Amine oxidase, flavin-containing PSPTO1126 0.0122
5122 Mersacidin decarboxylase mrsD 0.0122
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0122
5115 FkbI fkbI 0.0122
3133 UDP-galactopyranose mutase glf 0.0122
5099 UDP-galactopyranose mutase glf 0.0122
5095 Putidaredoxin reductase camA 0.0122
5109 Outer membrane protein p64k or PM-6 m-6 0.0122
5083 Cryptochrome DASH cry 0.0122
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0122
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0122
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0122
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0122
5081 L-aspartate oxidase nadB 0.0122
5111 Phenylacetone monooxygenase pamO 0.0122
1410 Oxidoreductase HSD17B6 0.0122
4725 Oxidoreductase Not Available 0.0122
5124 Oxidoreductase Not Available 0.0122
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0122
4120 NADPH--cytochrome P450 reductase POR 0.012
260 Cytochrome P450 51 ERG11 0.0119
761 Cytochrome P450 51 ERG11 0.0119
3163 Cytochrome P450 51 cyp51 0.0119
614 Progesterone receptor PGR 0.0118
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0117
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0117
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0117
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0116
136 Estrogen receptor ESR1 0.0115
1898 Cytochrome P450 1B1 CYP1B1 0.0114
4440 NADH peroxidase npr 0.0113
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0112
318 Alpha-2A adrenergic receptor ADRA2A 0.0112
6144 Solute carrier family 22 member 2 SLC22A2 0.0109
4148 Serine/threonine-protein kinase mTOR MTOR 0.0108
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0106
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0106
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0106
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0106
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0106
3594 Deoxyribodipyrimidine photo-lyase phr 0.0106
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0106
5080 Deoxyribodipyrimidine photo-lyase phr 0.0106
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0106
2526 NADPH-ferredoxin reductase fprA fprA 0.0106
2470 Pyruvate oxidase pox5 0.0106
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0106
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0106
5072 N,N-dimethylglycine oxidase dmg 0.0106
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0102
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0101
327 Glutathione reductase gor 0.0099
5110 Glutathione reductase GR2 0.0099
3102 Flavohemoprotein hmp 0.0099
4969 Flavohemoprotein hmp 0.0099
2893 Glycine oxidase thiO 0.0098
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.0098
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0098
638 D(3) dopamine receptor DRD3 0.0097
232 Corticosteroid-binding globulin SERPINA6 0.0097
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0095
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0094
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0094
605 Fumarate reductase flavoprotein subunit frdA 0.0093
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0093
3673 Fumarate reductase flavoprotein subunit fccA 0.0093
4912 Fumarate reductase flavoprotein subunit ifcA 0.0093
6549 Fumarate reductase flavoprotein subunit frdA 0.0093
6143 Solute carrier family 22 member 7 SLC22A7 0.0093
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0093
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0093
2567 Thymidylate synthase thyX thyX 0.0093
2823 Trypanothione reductase TPR 0.0093
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0092
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0092
2769 P-hydroxybenzoate hydroxylase pobA 0.0089
2809 P-hydroxybenzoate hydroxylase pobA 0.0089
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0088
590 5-hydroxytryptamine 2C receptor HTR2C 0.0088
23 D(1A) dopamine receptor DRD1 0.0087
341 5-hydroxytryptamine 3 receptor HTR3A 0.0087
76 Nitric-oxide synthase, brain NOS1 0.0086
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0086
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0086
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0086
2380 Monomeric sarcosine oxidase soxA 0.0085
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0085
126 D-lactate dehydrogenase dld 0.0085
3545 D-lactate dehydrogenase Not Available 0.0085
4510 D-lactate dehydrogenase ldhA 0.0085
737 Mineralocorticoid receptor NR3C2 0.0085
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0085
714 Glutathione reductase, mitochondrial GSR 0.0085
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0084
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0084
632 Alpha-1B adrenergic receptor ADRA1B 0.0082
6645 D-amino-acid oxidase DAO 0.0081
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0079
818 50S ribosomal protein L10 rplJ 0.0079
766 Beta-2 adrenergic receptor ADRB2 0.0078
3947 Xanthine dehydrogenase/oxidase XDH 0.0078
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0078
118 Organic cation/carnitine transporter 2 SLC22A5 0.0077
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0076
6148 Multidrug resistance-associated protein 7 ABCC10 0.0076
3941 Amine oxidase [flavin-containing] A MAOA 0.0075
811 Translocator protein TSPO 0.0075
713 Sodium-dependent dopamine transporter SLC6A3 0.0075
885 5-hydroxytryptamine 1B receptor HTR1B 0.0073
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0073
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0073
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0073
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0072
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0072
6182 Cytochrome P450 2J2 CYP2J2 0.0071
3939 Amine oxidase [flavin-containing] B MAOB 0.0071
2164 Multidrug resistance-associated protein 4 ABCC4 0.007
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0068
378 Alpha-2C adrenergic receptor ADRA2C 0.0068
6147 Solute carrier family 22 member 3 SLC22A3 0.0068
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0066
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0066
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0065
817 DNA topoisomerase 2-alpha TOP2A 0.0065
468 Cytochrome P450 4A11 CYP4A11 0.0065
6020 Aldehyde oxidase AOX1 0.0065
646 Malate dehydrogenase, cytoplasmic MDH1 0.0064
629 Alpha-2B adrenergic receptor ADRA2B 0.0064
6142 Solute carrier family 22 member 8 SLC22A8 0.0064
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0061
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0061
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0061
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0061
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.006
725 5-hydroxytryptamine 1D receptor HTR1D 0.0059
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0059
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0059
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0059
29 Tubulin beta-1 chain TUBB1 0.0058
432 D(4) dopamine receptor DRD4 0.0058
833 Organic cation/carnitine transporter 1 SLC22A4 0.0058
3923 Cholinesterase BCHE 0.0057
768 FK506-binding protein 1A FKBP1A 0.0057
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0057
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0057
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0057
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0057
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0057
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0057
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0057
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0056
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0056
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0056
789 Alpha-1D adrenergic receptor ADRA1D 0.0055
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0055
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0055
4237 50S ribosomal protein L22 rplV 0.0054
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0054
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0054
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0053
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0052
716 5-hydroxytryptamine 7 receptor HTR7 0.0052
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0051
444 Alcohol dehydrogenase 1B ADH1B 0.0051
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.005
477 DNA topoisomerase 4 subunit A parC 0.005
886 DNA topoisomerase 4 subunit A parC 0.005
6226 DNA topoisomerase 4 subunit A parC 0.005
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.005
193 Beta-1 adrenergic receptor ADRB1 0.005
666 NADP-dependent malic enzyme ME1 0.005
404 DNA gyrase subunit A gyrA 0.0049
6224 DNA gyrase subunit A gyrA 0.0049
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0049
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0048
723 Cytosolic phospholipase A2 PLA2G4A 0.0047
161 Tubulin beta chain TUBB 0.0046
312 Tubulin beta chain TUB2 0.0046
504 Mast/stem cell growth factor receptor KIT 0.0046
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0046
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0045
5330 General stress protein 69 yhdN 0.0045
5343 NADP-dependent fatty aldehyde dehydrogenase aldH 0.0045
3772 3-oxoacyl-[acyl-carrier-protein] reductase fabG 0.0045
5326 Oxidoreductase, short chain dehydrogenase/reductase family TM_0441 0.0045
5157 Dehydrogenase/reductase SDR family member 11 DHRS11 0.0045
5346 Oxidoreductase, aldo/keto reductase family TM_1009 0.0045
4403 Protein iolS iolS 0.0045
5333 Alcohol dehydrogenase, iron-containing TM_0920 0.0045
5332 MtdA bifunctional protein mtdA 0.0045
3778 NAD(P) transhydrogenase subunit beta pntB 0.0045
5322 Oxidoreductase ydhF ydhF 0.0045
5342 NADH-dependent butanol dehydrogenase, putative TM_0820 0.0045
814 Ryanodine receptor 1 RYR1 0.0045
952 Dipeptidyl peptidase 4 DPP4 0.0045
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0044
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0044
465 Calmodulin CALM1 0.0043
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0043
427 Substance-P receptor TACR1 0.0043
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0042
228 Beta platelet-derived growth factor receptor PDGFRB 0.0042
1256 5-hydroxytryptamine 6 receptor HTR6 0.0042
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0041
365 Dihydrofolate reductase DHFR 0.0041
2381 Dihydrofolate reductase DFR1 0.0041
2833 Dihydrofolate reductase Not Available 0.0041
2931 Dihydrofolate reductase folA 0.0041
3544 Dihydrofolate reductase folA 0.0041
3682 Dihydrofolate reductase folA 0.0041
6642 Dihydrofolate reductase folA 0.0041
6756 Dihydrofolate reductase dfrA 0.0041
407 Vascular endothelial growth factor receptor 2 KDR 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.004
238 Peroxisome proliferator-activated receptor gamma PPARG 0.004
1010 Cytochrome P450 51A1 CYP51A1 0.004
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.004
2375 ADP-L-glycero-D-manno-heptose-6-epimerase hldD 0.004
654 Flavin reductase BLVRB 0.004
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0039
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0039
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0039
4582 Putative pteridine reductase 2 ptr2 0.0039
989 L-xylulose reductase DCXR 0.0039
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0039
26 Vascular endothelial growth factor receptor 3 FLT4 0.0039
2305 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 0.0039
2636 Shikimate dehydrogenase aroE 0.0039
3515 Shikimate dehydrogenase aroE 0.0039
3446 NADP-dependent alcohol dehydrogenase adh 0.0039
5328 Prostaglandin F synthase Tb11.02.2310 0.0039
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0039
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0039
2286 Isocitrate dehydrogenase [NADP] icd 0.0039
2302 Isocitrate dehydrogenase [NADP] icd 0.0039
2771 Isocitrate dehydrogenase [NADP] icd 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0039
4238 50S ribosomal protein L4 rplD 0.0038
5578 50S ribosomal protein L4 rplD 0.0038
6173 50S ribosomal protein L4 rplD 0.0038
6219 50S ribosomal protein L4 rplD 0.0038
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0038
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0038
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0038
208 DNA-directed RNA polymerase beta' chain rpoC 0.0038
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0038
1483 Membrane copper amine oxidase AOC3 0.0038
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0037
4604 Liver carboxylesterase 1 CES1 0.0037
1852 Microtubule-associated protein 2 MAP2 0.0037
32 Vascular endothelial growth factor receptor 1 FLT1 0.0037
569 Retinal dehydrogenase 2 ALDH1A2 0.0037
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0036
68 Cannabinoid receptor 1 CNR1 0.0036
6297 Prostaglandin reductase 1 PTGR1 0.0036
4531 Putative ketoacyl reductase actIII 0.0036
284 DNA-directed RNA polymerase beta chain rpoB 0.0036
5773 DNA-directed RNA polymerase beta chain rpoB 0.0036
3062 Aspartate-semialdehyde dehydrogenase asd 0.0036
6862 Aldo-keto reductase family 1 member B10 AKR1B10 0.0036
122 P2Y purinoceptor 12 P2RY12 0.0035
611 Retinal dehydrogenase 1 ALDH1A1 0.0035
94 5-hydroxytryptamine 4 receptor HTR4 0.0035
856 Vitamin D3 receptor VDR 0.0035
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
939 50S ribosomal protein L3 rplC 0.0035
322 Vasopressin V2 receptor AVPR2 0.0034
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0034
163 D(1B) dopamine receptor DRD5 0.0034
2539 Tubulin alpha-1 chain TUBA4A 0.0034
2675 Pteridine reductase 1 PTR1 0.0034
2159 Quinone oxidoreductase CRYZ 0.0034
6136 Multidrug resistance-associated protein 5 ABCC5 0.0034
1124 Sepiapterin reductase SPR 0.0034
844 Epidermal growth factor receptor EGFR 0.0034
474 Acetylcholinesterase ACHE 0.0033
295 Carbonic anhydrase 1 CA1 0.0033
473 L-lactate dehydrogenase A chain LDHA 0.0033
1024 Solute carrier family 22 member 11 SLC22A11 0.0033
1656 CYP2B protein CYP2B 0.0033
592 Carbonic anhydrase 4 CA4 0.0032
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0032
869 Estrogen receptor beta ESR2 0.0032
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0032
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0032
6141 Sodium/bile acid cotransporter SLC10A1 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
822 Aldose reductase AKR1B1 0.0031
816 Biliverdin reductase A BLVRA 0.0031
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0031
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0031
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0031
2578 Tubulin beta-3 chain TUBB3 0.003
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
469 Annexin A1 ANXA1 0.003
80 Peroxisome proliferator-activated receptor alpha PPARA 0.003
5923 Microtubule-associated protein tau MAPT 0.003
5924 Microtubule-associated protein 4 MAP4 0.003
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.003
6220 Aryl hydrocarbon receptor AHR 0.003
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.003
6043 Putative G-protein coupled receptor 44 GPR44 0.003
165 FL cytokine receptor FLT3 0.003
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0028
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0028
396 Alcohol dehydrogenase 4 ADH4 0.0028
328 Sorbitol dehydrogenase SORD 0.0028
597 Dihydropteridine reductase QDPR 0.0028
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0028
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0028
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0028
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0028
528 5-hydroxytryptamine 1E receptor HTR1E 0.0028
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0028
6014 Cytochrome P450 2A13 CYP2A13 0.0027
436 5-hydroxytryptamine 2B receptor HTR2B 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0027
273 Apoptosis regulator Bcl-2 BCL2 0.0027
77 L-lactate dehydrogenase B chain LDHB 0.0027
12 Alcohol dehydrogenase class 3 ADH5 0.0027
1196 Complement decay-accelerating factor CD55 0.0026
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0026
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0026
251 Alcohol dehydrogenase 1A ADH1A 0.0026
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0026
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0026
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0026
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0026
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0026
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0026
49 Endothelin B receptor EDNRB 0.0026
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0026
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0026
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0025
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0025
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0025
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0025
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0024
705 Glutamate receptor 1 GRIA1 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
4773 Deoxycytidine kinase DCK 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
357 Carbonic anhydrase 2 CA2 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
124 Histamine H2 receptor HRH2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0024
1525 Heparin-binding growth factor 2 FGF2 0.0023
84 Nuclear receptor 0B1 NR0B1 0.0023
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0023
2808 Chloramphenicol acetyltransferase 3 cat3 0.0023
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0023
1353 DNA topoisomerase 1 TOP1 0.0023
3552 DNA topoisomerase 1 topA 0.0023
777 Tumor necrosis factor TNF 0.0023
16 Adenosine A1 receptor ADORA1 0.0023
70 Type-1 angiotensin II receptor AGTR1 0.0023
4122 Histone deacetylase 2 HDAC2 0.0023
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0022
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
517 Alcohol dehydrogenase 1C ADH1C 0.0022
1178 Adenosine A2a receptor ADORA2A 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
6137 Multidrug resistance-associated protein 6 ABCC6 0.0021
2449 Tubulin alpha-3 chain TUBA1A 0.0021
298 Renin REN 0.0021
6506 Stathmin-4 STMN4 0.0021
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0021
3601 Dihydropteroate synthase 1 folP1 0.0021
3807 Dihydropteroate synthase 1 folP1 0.0021
3808 Dihydropteroate synthase 2 folP2 0.0021
2417 Chloramphenicol acetyltransferase cat 0.0021
3278 Chloramphenicol acetyltransferase cat 0.0021
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0021
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0021
4423 Levodione reductase lvr 0.0021
4428 Redox-sensing transcriptional repressor rex rex 0.0021
4505 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase bphB 0.0021
4456 Inorganic polyphosphate/ATP-NAD kinase ppnK 0.0021
4447 Hypothetical protein yhfP yhfP 0.0021
4449 ADP-ribosyltransferase Not Available 0.0021
2350 3-isopropylmalate dehydrogenase leuB 0.0021
3092 3-isopropylmalate dehydrogenase leuB 0.0021
4495 3-oxoacyl-(Acyl carrier protein) reductase TM_1169 0.0021
4507 Alanine dehydrogenase ald 0.0021
4475 Hypothetical protein Rv0046c/MT0052 ino1 0.0021
4497 Benzyl alcohol dehydrogenase xylB 0.0021
4435 L-aspartate dehydrogenase nadX 0.0021
4446 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase Not Available 0.0021
4472 Glucose 1-dehydrogenase Not Available 0.0021
4418 AGR_L_3209p AGR_L_3209 0.0021
4443 Quinate/shikimate dehydrogenase ydiB 0.0021
4500 L-lactate dehydrogenase 2 ldh2 0.0021
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.0021
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.0021
3381 Alcohol dehydrogenase Not Available 0.0021
4508 Alcohol dehydrogenase adhA 0.0021
4414 Dehydrogenase TT_P0035 0.0021
4455 Glycerol dehydrogenase gldA 0.0021
4506 Myo-inositol-1-phosphate synthase-related protein TM_1419 0.0021
3735 NAD(P) transhydrogenase subunit alpha part 1 pntAA 0.0021
4466 Glutathione-independent formaldehyde dehydrogenase fdhA 0.0021
4502 Formate dehydrogenase Not Available 0.0021
4487 Transcriptional regulator nadR nadR 0.0021
3729 Citrate synthase gltA 0.0021
4575 Citrate synthase cit 0.0021
4580 Citrate synthase gltA 0.0021
4471 CDP-D-glucose-4,6-dehydratase ascB 0.0021
4451 Vip2Ac vip2Ac 0.0021
4467 Alpha-glucosidase, putative TM_0752 0.0021
4448 L-2-hydroxyisocaproate dehydrogenase Not Available 0.0021
780 Retinoic acid receptor RXR-gamma RXRG 0.0021
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0021
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.002
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.002
2810 Dr hemagglutinin structural subunit draA 0.002
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.002
215 Sodium channel protein type 11 subunit alpha SCN11A 0.002
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.002
1517 Beta-3 adrenergic receptor ADRB3 0.002
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.002
3913 Glutamic acid decarboxylase GAD65 0.002
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
373 Transthyretin TTR 0.0019
3932 Glutathione S-transferase A2 GSTA2 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
233 Potassium channel subfamily K member 2 KCNK2 0.0019
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0019
88 Retinoic acid receptor RXR-beta RXRB 0.0019
319 Opioid receptor, sigma 1 OPRS1 0.0019
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0019
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
565 Extracellular calcium-sensing receptor CASR 0.0018
1630 Integrin beta-2 ITGB2 0.0018
683 Potassium transporter GK0582 0.0018
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0018
976 Platelet glycoprotein IX GP9 0.0018
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0017
543 Penicillin-binding protein 1B mrcB 0.0017
6186 Penicillin-binding protein 1B ponB 0.0017
6822 Penicillin-binding protein 1b pbp1b 0.0017
6844 Penicillin-binding protein 1b pbp1b 0.0017
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0017
3177 dTDP-glucose 4,6-dehydratase rfbB 0.0017
4499 dTDP-glucose 4,6-dehydratase rmlB 0.0017
4427 TDP-glucose-4,6-dehydratase desIV 0.0017
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.0017
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.0017
3059 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase fabG3 0.0017
2967 CDP-paratose 2-epimerase rfbE 0.0017
4482 UDP-galactose 4-epimerase galE 0.0017
2538 6-phospho-beta-glucosidase bglT bglT 0.0017
2393 Maltose-6'-phosphate glucosidase glvA 0.0017
4509 Acetoin(diacetyl) reductase budC 0.0017
3081 3-dehydroquinate synthase aroB 0.0017
2507 Diphtheria toxin Not Available 0.0017
4503 NADPH-flavin oxidoreductase frp 0.0017
6698 Dehydrogenase/reductase SDR family member 4-like 2 DHRS4L2 0.0017
4450 Iota toxin component Ia Not Available 0.0017
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0017
159 Penicillin-binding protein 2B penA 0.0017
6121 Penicillin-binding protein 2B penA 0.0017
3615 Dihydrodipicolinate reductase dapB 0.0017
3618 Dihydrodipicolinate reductase dapB 0.0017
4462 Dihydrodipicolinate reductase dapB 0.0017
2591 Urocanate hydratase hutU 0.0017
1199 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 ART1 0.0017
4498 Ornithine cyclodeaminase PP3533 0.0017
2424 L-lactate dehydrogenase ldh 0.0017
2641 L-lactate dehydrogenase Not Available 0.0017
4437 L-lactate dehydrogenase ldh 0.0017
4442 L-lactate dehydrogenase ldh 0.0017
2018 Deoxyhypusine synthase DHPS 0.0017
2336 2,3-diketo-L-gulonate reductase dlgD 0.0017
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.0017
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0017
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0017
4496 C-terminal-binding protein 1 CTBP1 0.0017
2881 Gamma-aminobutyraldehyde dehydrogenase prr 0.0017
3904 Alanine aminotransferase 2 GPT2 0.0016
735 Alanine aminotransferase 1 GPT 0.0016
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0016
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0016
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0016
2683 Mono-ADP-ribosyltransferase C3 C3 0.0016
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0016
173 Toll-like receptor 7 TLR7 0.0016
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0016
174 Sigma 1-type opioid receptor SIGMAR1 0.0016
3233 Bile acid receptor NR1H4 0.0015
4504 WbpP Not Available 0.0015
3296 Nicotinamide mononucleotide adenylyltransferase 1 NMNAT1 0.0015
3367 GDP-mannose 6-dehydrogenase algD 0.0015
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0015
1757 Myeloperoxidase MPO 0.0015
4318 Siroheme synthase cysG 0.0015
738 Monocarboxylate transporter 1 SLC16A1 0.0015
6138 Multidrug resistance protein 3 ABCB4 0.0015
4343 Alpha-glucosidase aglA 0.0015
2799 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Not Available 0.0015
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0015
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0015
6048 Troponin C, skeletal muscle TNNC2 0.0015
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0015
921 Glutamate receptor 2 GRIA2 0.0015
719 Retinoic acid receptor responder protein 1 RARRES1 0.0015
770 Retinoic acid-induced protein 3 GPRC5A 0.0015
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0015
275 Arachidonate 5-lipoxygenase ALOX5 0.0015
1629 Transcription factor AP-1 JUN 0.0015
63 Malate dehydrogenase mdh 0.0015
2329 Malate dehydrogenase mdh 0.0015
3445 Malate dehydrogenase mdh 0.0015
4420 Malate dehydrogenase mdh 0.0015
4438 Malate dehydrogenase mdh 0.0015
4476 Mannitol dehydrogenase mtlD 0.0015
581 Cytochrome P450 2R1 CYP2R1 0.0015
1618 High affinity nerve growth factor receptor NTRK1 0.0015
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0015
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0015
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0015
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0015
206 3-keto-steroid reductase HSD17B7 0.0015
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0015
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0015
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0015
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0015
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0015
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0015
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0015
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0015
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0015
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0015
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0015
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0015
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0015
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0015
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0015
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0015
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0015
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0015
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0015
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0015
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0015
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0015
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0015
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0015
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0015
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0015
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0015
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0015
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0015
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0015
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0015
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0015
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0015
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0015
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0015
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0015
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0015
107 C-4 methylsterol oxidase SC4MOL 0.0015
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0015
729 GDP-L-fucose synthetase TSTA3 0.0015
3463 GDP-L-fucose synthetase fcl 0.0015
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0015
644 Heme oxygenase 2 HMOX2 0.0015
4982 Heme oxygenase 2 pbsA2 0.0015
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0015
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0015
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0015
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0015
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0015
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0015
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0015
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0015
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0014
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0014
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0014
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0014
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0014
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0014
34 7-dehydrocholesterol reductase DHCR7 0.0014
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0014
711 UDP-glucose 6-dehydrogenase UGDH 0.0014
3672 UDP-glucose 6-dehydrogenase hasB 0.0014
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0014
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0014
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0014
3726 D-3-phosphoglycerate dehydrogenase serA 0.0014
4291 D-3-phosphoglycerate dehydrogenase serA 0.0014
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0014
167 L-lactate dehydrogenase C chain LDHC 0.0014
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0014
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0014
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0014
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0014
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0014
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0014
643 Peroxisomal bifunctional enzyme EHHADH 0.0014
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0014
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0014
6044 Serum paraoxonase/lactonase 3 PON3 0.0014
1541 Metalloproteinase mmp20 0.0014
3333 Nicotinamide mononucleotide adenylyltransferase 3 NMNAT3 0.0014
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0014
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0014
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0014
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0014
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0014
2826 Glucose--fructose oxidoreductase gfo 0.0014
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0014
3070 Adenosylhomocysteinase AHCY 0.0014
4424 Adenosylhomocysteinase PFE1050w 0.0014
6278 Adenosylhomocysteinase ahcY 0.0014
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0014
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0014
3191 Histidinol dehydrogenase hisD 0.0014
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0014
6432 Transporter snf 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0014
857 Malate dehydrogenase, mitochondrial MDH2 0.0014
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0014
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0013
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0013
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0013
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0013
572 Integrin alpha-L ITGAL 0.0013
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0013
267 Plasminogen activator inhibitor 1 SERPINE1 0.0013
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0013
3809 Estrogen-related receptor gamma ESRRG 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
4491 DNA ligase, NAD-dependent ligA 0.0013
1864 RET proto-oncogene RET 0.0013
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0013
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0013
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0013
2762 UDP-glucose 4-epimerase GALE 0.0013
3461 UDP-glucose 4-epimerase galE 0.0013
891 Dihydropteroate synthase folP 0.0013
5359 Dihydropteroate synthase folP 0.0013
7175 Dihydropteroate synthase sulI 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
6026 Alcohol dehydrogenase 6 ADH6 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
6126 Carbonic anhydrase 7 CA7 0.0012
627 11-cis retinol dehydrogenase RDH5 0.0012
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
571 Melatonin receptor type 1A MTNR1A 0.0012
362 Melatonin receptor type 1B MTNR1B 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0012
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0012
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0012
13 Aminomethyltransferase, mitochondrial AMT 0.0012
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0012
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0012
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0012
1295 Fatty acid synthase FASN 0.0012
904 Glutathione S-transferase P GSTP1 0.0012
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0012
626 Cysteine dioxygenase type 1 CDO1 0.0012
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0012
482 Glycine receptor subunit alpha-1 GLRA1 0.0012
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0012
5934 Cytochrome P450 26A1 CYP26A1 0.0012
6085 Fatty acid-binding protein, intestinal FABP2 0.0012
6221 Steroid hormone receptor ERR1 ESRRA 0.0012
751 Potassium channel subfamily K member 6 KCNK6 0.0011
239 Coagulation factor X F10 0.0011
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
810 Heme oxygenase 1 HMOX1 0.0011
3391 Heme oxygenase 1 pbsA1 0.0011
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0011
5787 Angiopoietin-1 receptor TEK 0.0011
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0011
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
172 Potassium channel subfamily K member 1 KCNK1 0.0011
54 Prothrombin F2 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4203 Histamine N-methyltransferase HNMT 0.001
4116 Dihydropteroate synthetase Not Available 0.001
4228 Keratin, type II cytoskeletal 7 KRT7 0.001
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.001
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.001
1144 Hepatocyte growth factor receptor MET 0.001
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.001
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
279 Tyrosinase TYR 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
5300 Antigen peptide transporter 1 TAP1 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
6824 Tyrosine-protein kinase Lyn LYN 0.001
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.001
162 Retinoic acid receptor gamma-1 RARG 0.0009
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0009
537 ATP synthase delta chain, mitochondrial ATP5D 0.0009
3086 Plasmepsin-2 Not Available 0.0009
459 Retinoic acid receptor RXR-alpha RXRA 0.0009
7 Nitric oxide synthase, inducible NOS2 0.0009
1048 Protein S100-A13 S100A13 0.0009
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0009
2226 Protein S100-A12 S100A12 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
1648 Elastin ELN 0.0009
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
153 Dopamine beta-hydroxylase DBH 0.0009
183 Vascular endothelial growth factor A VEGFA 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
2132 Protein S100-B S100B 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
3404 Exotoxin A eta 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0008
3856 Fibroblast growth factor receptor 3 FGFR3 0.0008
2091 Endoplasmin HSP90B1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0007
896 Glutathione S-transferase Mu 1 GSTM1 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0007
130 Prostacyclin synthase PTGIS 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0007
2112 Toll-like receptor 9 TLR9 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2298 Cytochrome P450-cam camC 0.0007
518 Peroxidase/catalase T katG 0.0007
2290 ADP-ribosyl cyclase 2 BST1 0.0007
24 Thymidylate synthase TMP1 0.0007
359 Thymidylate synthase TYMS 0.0007
2626 Thymidylate synthase thyA 0.0007
2729 Thymidylate synthase thyA 0.0007
5352 Thymidylate synthase THYA 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
1830 5'-nucleotidase NT5E 0.0007
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0007
164 Histamine H4 receptor HRH4 0.0007
125 DNA polymerase beta POLB 0.0007
4311 tRNA TRDMT1 0.0007
4325 tRNA trmD 0.0007
4328 tRNA trmD 0.0007
131 Synaptic vesicular amine transporter SLC18A2 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
3937 Fatty-acid amide hydrolase FAAH 0.0006
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0006
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0006
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0006
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0006
144 Hemoglobin subunit alpha HBA1 0.0006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
106 Cannabinoid receptor 2 CNR2 0.0006
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0006
6174 50S ribosomal protein L32 rpmF 0.0006
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0006
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0006
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0006
563 Thyroid peroxidase TPO 0.0006
4192 DNA topoisomerase 2-beta TOP2B 0.0006
6167 Organic solute transporter subunit beta OSTB 0.0006
6166 Organic solute transporter subunit alpha OSTA 0.0006
3611 Cytidine deaminase cdd 0.0006
3707 Cytidine deaminase cdd 0.0006
4211 Cytidine deaminase CDA 0.0006
936 Ephrin type-A receptor 2 EPHA2 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
634 Squalene monooxygenase SQLE 0.0006
7196 Squalene monooxygenase ERG1 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
1341 Histamine H3 receptor HRH3 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
1262 Corticotropin-lipotropin POMC 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0005
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0005
244 Angiotensin-converting enzyme ACE 0.0005
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0005
6211 Tubulin epsilon chain TUBE1 0.0005
6212 Tubulin gamma-1 chain TUBG1 0.0005
6210 Tubulin delta chain TUBD1 0.0005
823 Fibroblast growth factor receptor 2 FGFR2 0.0005
3810 Catechol O-methyltransferase COMT 0.0005
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0005
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0005
1714 Mitogen-activated protein kinase 3 MAPK3 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0005
6149 Solute carrier family 22 member 10 SLC22A10 0.0005
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0004
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0004
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0004
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
1992 Vitamin D-binding protein GC 0.0004
4103 Proteasome subunit beta type 2 PSMB2 0.0004
4101 Proteasome subunit beta type 1 PSMB1 0.0004
4102 Proteasome subunit beta type 5 PSMB5 0.0004
1374 Natriuretic peptides B NPPB 0.0004
1827 Gap junction alpha-1 protein GJA1 0.0004
1908 Vascular cell adhesion protein 1 VCAM1 0.0004
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0004
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0004
1063 Signal transducer and activator of transcription 5B STAT5B 0.0004
2216 Fibroblast growth factor receptor 4 FGFR4 0.0004
4217 Telomerase reverse transcriptase TERT 0.0004
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0004
511 5-hydroxytryptamine 1F receptor HTR1F 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
6146 High affinity copper uptake protein 1 SLC31A1 0.0004
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0004
820 Glycine receptor subunit alpha-2 GLRA2 0.0003
268 Adenosine A2b receptor ADORA2B 0.0003
828 Phenylalanine-4-hydroxylase PAH 0.0003
3109 Phenylalanine-4-hydroxylase phhA 0.0003
758 Thyroid hormone receptor alpha THRA 0.0003
33 Cystine/glutamate transporter SLC7A11 0.0003
484 Tyrosine-protein kinase ABL2 ABL2 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0003
5798 Mitogen-activated protein kinase 11 MAPK11 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
2320 Thymidine kinase, cytosolic TK1 0.0003
291 Nitric-oxide synthase, endothelial NOS3 0.0003
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
760 Fibroblast growth factor 1 FGF1 0.0003
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0003
1268 Neuropeptide S receptor NPSR1 0.0003
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0003
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0003
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0003
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0003
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0003
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0003
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0003
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0003
6218 Pannexin-1 PANX1 0.0003
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0003
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0003
1039 Histone deacetylase 9 HDAC9 0.0003
908 Glutathione S-transferase theta-1 GSTT1 0.0003
6073 Potassium channel subfamily K member 9 KCNK9 0.0003
6072 Potassium channel subfamily K member 3 KCNK3 0.0003
1360 Sphingomyelin phosphodiesterase SMPD1 0.0003
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0002
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0002
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0002
3957 Adenosine deaminase ADA 0.0002
6168 Solute carrier family 22 member 16 SLC22A16 0.0002
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0002
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0002
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0002
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
2207 Rhodopsin RHO 0.0002
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0002
489 Monocarboxylate transporter 2 SLC16A7 0.0002
2981 Phospholipase A2, membrane associated PLA2G2A 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0001
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
3116 Bacterioferritin bfr 0.0001
4906 Bacterioferritin bfr 0.0001
4965 Bacterioferritin bfr 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
3221 Cytochrome c4 cc4 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0
1507 Cytochrome c CYCS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
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