DT-Web

DB02383 - Tolrestat


Identification
Name Tolrestat
Accession Number DB02383 (EXPT03082)
Type small molecule
Description Tolrestat (INN) (AY-27773) is an aldose reductase inhibitor which was approved for the control of certain diabetic complications. While it was approved for marketed in several countries, it failed a Phase III trial in the U.S. due to toxicity and never received FDA approval. It was discontinued by Wyeth in 1997 because of the risk of severe liver toxicity and death. It was sold under the tradename Alredase. [Wikipedia]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 357.347
Groups withdrawn
Monoisotopic Weight 357.064648624
Pharmacology
Indication For the pharmacological control of certain diabetic complications.
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Oral, mouse: LD50 = 300 mg/kg; Oral, rabbit: LD50 = 3200 mg/kg; Oral, rat: LD50 = 980 mg/kg.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Aldose reductase
Name Aldose reductase
Gene Name AKR1B1
Pharmacological action unknown
Actions inhibitor
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.8658
Alcohol dehydrogenase [NADP+]
Name Alcohol dehydrogenase [NADP+]
Gene Name AKR1A1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.3228
Aldo-keto reductase family 1 member B10
Name Aldo-keto reductase family 1 member B10
Gene Name AKR1B10
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.7628

Predictions


Id Partner name Gene Name Score
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.023
6447 Guanine nucleotide-binding protein G(t) subunit alpha-1 GNAT1 0.0225
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0218
5346 Oxidoreductase, aldo/keto reductase family TM_1009 0.0214
5330 General stress protein 69 yhdN 0.0214
4403 Protein iolS iolS 0.0214
5322 Oxidoreductase ydhF ydhF 0.0214
5326 Oxidoreductase, short chain dehydrogenase/reductase family TM_0441 0.0214
5157 Dehydrogenase/reductase SDR family member 11 DHRS11 0.0214
5332 MtdA bifunctional protein mtdA 0.0214
3772 3-oxoacyl-[acyl-carrier-protein] reductase fabG 0.0214
5342 NADH-dependent butanol dehydrogenase, putative TM_0820 0.0214
5333 Alcohol dehydrogenase, iron-containing TM_0920 0.0214
5343 NADP-dependent fatty aldehyde dehydrogenase aldH 0.0214
3778 NAD(P) transhydrogenase subunit beta pntB 0.0214
646 Malate dehydrogenase, cytoplasmic MDH1 0.0212
5328 Prostaglandin F synthase Tb11.02.2310 0.02
291 Nitric-oxide synthase, endothelial NOS3 0.0195
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0192
666 NADP-dependent malic enzyme ME1 0.0192
2375 ADP-L-glycero-D-manno-heptose-6-epimerase hldD 0.0186
5073 Ferredoxin--NADP reductase petH 0.0186
5076 Ferredoxin--NADP reductase fpr 0.0186
5119 Ferredoxin--NADP reductase petH 0.0186
5121 Ferredoxin--NADP reductase fpr 0.0186
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0186
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0185
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0185
4582 Putative pteridine reductase 2 ptr2 0.0184
76 Nitric-oxide synthase, brain NOS1 0.0184
4628 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase gapN 0.0184
989 L-xylulose reductase DCXR 0.0184
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0184
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0184
2636 Shikimate dehydrogenase aroE 0.0184
3515 Shikimate dehydrogenase aroE 0.0184
2305 Isocitrate dehydrogenase [NADP] cytoplasmic IDH1 0.0184
3446 NADP-dependent alcohol dehydrogenase adh 0.0184
2286 Isocitrate dehydrogenase [NADP] icd 0.0184
2302 Isocitrate dehydrogenase [NADP] icd 0.0184
2771 Isocitrate dehydrogenase [NADP] icd 0.0184
4120 NADPH--cytochrome P450 reductase POR 0.0184
864 Gag-Pol polyprotein gag-pol 0.018
2237 Gag-Pol polyprotein gag-pol 0.018
2326 Gag-Pol polyprotein gag-pol 0.018
2451 Gag-Pol polyprotein gag-pol 0.018
2901 Gag-Pol polyprotein gag-pol 0.018
3165 Gag-Pol polyprotein gag-pol 0.018
3722 Gag-Pol polyprotein gag-pol 0.018
6306 Gag-Pol polyprotein gag-pol 0.018
6624 Gag-Pol polyprotein gag-pol 0.018
4531 Putative ketoacyl reductase actIII 0.017
6297 Prostaglandin reductase 1 PTGR1 0.0169
3062 Aspartate-semialdehyde dehydrogenase asd 0.0169
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0163
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0162
2675 Pteridine reductase 1 PTR1 0.0161
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0161
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.016
1124 Sepiapterin reductase SPR 0.016
444 Alcohol dehydrogenase 1B ADH1B 0.016
2159 Quinone oxidoreductase CRYZ 0.0157
654 Flavin reductase BLVRB 0.0155
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0149
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0146
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0146
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0146
2538 6-phospho-beta-glucosidase bglT bglT 0.0137
2393 Maltose-6'-phosphate glucosidase glvA 0.0137
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0135
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0133
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0121
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0121
365 Dihydrofolate reductase DHFR 0.0117
2381 Dihydrofolate reductase DFR1 0.0117
2833 Dihydrofolate reductase Not Available 0.0117
2931 Dihydrofolate reductase folA 0.0117
3544 Dihydrofolate reductase folA 0.0117
3682 Dihydrofolate reductase folA 0.0117
6642 Dihydrofolate reductase folA 0.0117
6756 Dihydrofolate reductase dfrA 0.0117
6168 Solute carrier family 22 member 16 SLC22A16 0.011
1881 Hexokinase-1 HK1 0.0095
2439 Alpha,alpha-trehalose-phosphate synthase [UDP-forming] otsA 0.0095
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0091
2503 Phosphomannomutase/phosphoglucomutase algC 0.009
2597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] glmS 0.0087
3947 Xanthine dehydrogenase/oxidase XDH 0.0085
2206 Glucose-6-phosphate isomerase GPI 0.0082
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0079
6137 Multidrug resistance-associated protein 6 ABCC6 0.0078
6148 Multidrug resistance-associated protein 7 ABCC10 0.0073
6043 Putative G-protein coupled receptor 44 GPR44 0.007
1714 Mitogen-activated protein kinase 3 MAPK3 0.007
7 Nitric oxide synthase, inducible NOS2 0.0069
817 DNA topoisomerase 2-alpha TOP2A 0.0068
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0064
1898 Cytochrome P450 1B1 CYP1B1 0.0062
776 Bile salt export pump ABCB11 0.0062
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0061
862 Multidrug resistance-associated protein 1 ABCC1 0.0057
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0057
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0057
816 Biliverdin reductase A BLVRA 0.0057
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0057
1152 Glycogen phosphorylase, muscle form PYGM 0.0057
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0053
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0053
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0052
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0052
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0052
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0052
328 Sorbitol dehydrogenase SORD 0.0051
396 Alcohol dehydrogenase 4 ADH4 0.0051
597 Dihydropteridine reductase QDPR 0.0051
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0051
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0049
77 L-lactate dehydrogenase B chain LDHB 0.0048
12 Alcohol dehydrogenase class 3 ADH5 0.0048
6030 Cytochrome P450 2B6 CYP2B6 0.0048
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0048
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0047
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0047
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0047
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0047
473 L-lactate dehydrogenase A chain LDHA 0.0046
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0046
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0044
569 Retinal dehydrogenase 2 ALDH1A2 0.0043
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0043
611 Retinal dehydrogenase 1 ALDH1A1 0.0042
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0042
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0042
251 Alcohol dehydrogenase 1A ADH1A 0.0041
1588 Multidrug resistance protein 1 ABCB1 0.0041
857 Malate dehydrogenase, mitochondrial MDH2 0.0041
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.004
4119 Cytochrome P450 2D6 CYP2D6 0.004
4512 Cytochrome P450 3A4 CYP3A4 0.0036
714 Glutathione reductase, mitochondrial GSR 0.0036
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0035
290 Prostaglandin G/H synthase 2 PTGS2 0.0035
517 Alcohol dehydrogenase 1C ADH1C 0.0034
4428 Redox-sensing transcriptional repressor rex rex 0.0033
4449 ADP-ribosyltransferase Not Available 0.0033
4418 AGR_L_3209p AGR_L_3209 0.0033
4435 L-aspartate dehydrogenase nadX 0.0033
4446 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase Not Available 0.0033
4423 Levodione reductase lvr 0.0033
4505 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase bphB 0.0033
4443 Quinate/shikimate dehydrogenase ydiB 0.0033
4456 Inorganic polyphosphate/ATP-NAD kinase ppnK 0.0033
4448 L-2-hydroxyisocaproate dehydrogenase Not Available 0.0033
4447 Hypothetical protein yhfP yhfP 0.0033
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.0033
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.0033
3381 Alcohol dehydrogenase Not Available 0.0033
4508 Alcohol dehydrogenase adhA 0.0033
4414 Dehydrogenase TT_P0035 0.0033
2350 3-isopropylmalate dehydrogenase leuB 0.0033
3092 3-isopropylmalate dehydrogenase leuB 0.0033
4471 CDP-D-glucose-4,6-dehydratase ascB 0.0033
4507 Alanine dehydrogenase ald 0.0033
4475 Hypothetical protein Rv0046c/MT0052 ino1 0.0033
4455 Glycerol dehydrogenase gldA 0.0033
4497 Benzyl alcohol dehydrogenase xylB 0.0033
3735 NAD(P) transhydrogenase subunit alpha part 1 pntAA 0.0033
4466 Glutathione-independent formaldehyde dehydrogenase fdhA 0.0033
4487 Transcriptional regulator nadR nadR 0.0033
4495 3-oxoacyl-(Acyl carrier protein) reductase TM_1169 0.0033
3729 Citrate synthase gltA 0.0033
4575 Citrate synthase cit 0.0033
4580 Citrate synthase gltA 0.0033
4451 Vip2Ac vip2Ac 0.0033
4472 Glucose 1-dehydrogenase Not Available 0.0033
4506 Myo-inositol-1-phosphate synthase-related protein TM_1419 0.0033
20 Prostaglandin G/H synthase 1 PTGS1 0.0033
4500 L-lactate dehydrogenase 2 ldh2 0.0033
4502 Formate dehydrogenase Not Available 0.0033
4467 Alpha-glucosidase, putative TM_0752 0.0033
587 Serum albumin ALB 0.0031
6024 Cytochrome P450 1A1 CYP1A1 0.0031
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0031
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0031
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0031
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0031
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0031
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0031
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0031
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0031
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0031
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0031
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0031
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0031
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0031
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0031
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0031
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0031
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0031
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0031
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0031
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0031
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0031
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0031
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0031
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0031
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0031
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0031
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0031
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0031
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0031
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0031
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0031
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0031
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0031
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0031
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0031
167 L-lactate dehydrogenase C chain LDHC 0.0031
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0031
729 GDP-L-fucose synthetase TSTA3 0.0031
3463 GDP-L-fucose synthetase fcl 0.0031
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0031
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0031
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0031
644 Heme oxygenase 2 HMOX2 0.0031
4982 Heme oxygenase 2 pbsA2 0.0031
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0031
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0031
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0031
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0031
206 3-keto-steroid reductase HSD17B7 0.0031
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0031
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0031
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0031
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0031
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0031
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0031
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0031
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0031
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0031
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0031
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0031
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0031
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0031
3726 D-3-phosphoglycerate dehydrogenase serA 0.0031
4291 D-3-phosphoglycerate dehydrogenase serA 0.0031
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0031
711 UDP-glucose 6-dehydrogenase UGDH 0.0031
3672 UDP-glucose 6-dehydrogenase hasB 0.0031
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0031
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0031
107 C-4 methylsterol oxidase SC4MOL 0.0031
34 7-dehydrocholesterol reductase DHCR7 0.0031
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0031
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0031
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0031
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0031
643 Peroxisomal bifunctional enzyme EHHADH 0.0031
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0031
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0031
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0031
1729 Solute carrier family 22 member 6 SLC22A6 0.003
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0027
4486 Phenol 2-hydroxylase component B pheA2 0.0027
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.0027
4439 Ferredoxin reductase bphA4 0.0027
4427 TDP-glucose-4,6-dehydratase desIV 0.0027
3177 dTDP-glucose 4,6-dehydratase rfbB 0.0027
4499 dTDP-glucose 4,6-dehydratase rmlB 0.0027
4477 Dihydrolipoyl dehydrogenase lpdV 0.0027
5077 Dihydrolipoyl dehydrogenase Not Available 0.0027
5117 Dihydrolipoyl dehydrogenase lpd 0.0027
4482 UDP-galactose 4-epimerase galE 0.0027
2967 CDP-paratose 2-epimerase rfbE 0.0027
4503 NADPH-flavin oxidoreductase frp 0.0027
2507 Diphtheria toxin Not Available 0.0027
4509 Acetoin(diacetyl) reductase budC 0.0027
3081 3-dehydroquinate synthase aroB 0.0027
1199 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 ART1 0.0027
6698 Dehydrogenase/reductase SDR family member 4-like 2 DHRS4L2 0.0027
3615 Dihydrodipicolinate reductase dapB 0.0027
3618 Dihydrodipicolinate reductase dapB 0.0027
4462 Dihydrodipicolinate reductase dapB 0.0027
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0027
2591 Urocanate hydratase hutU 0.0027
4450 Iota toxin component Ia Not Available 0.0027
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.0027
3059 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase fabG3 0.0027
126 D-lactate dehydrogenase dld 0.0027
3545 D-lactate dehydrogenase Not Available 0.0027
4510 D-lactate dehydrogenase ldhA 0.0027
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0027
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.0027
2424 L-lactate dehydrogenase ldh 0.0027
2641 L-lactate dehydrogenase Not Available 0.0027
4437 L-lactate dehydrogenase ldh 0.0027
4442 L-lactate dehydrogenase ldh 0.0027
4498 Ornithine cyclodeaminase PP3533 0.0026
4496 C-terminal-binding protein 1 CTBP1 0.0026
2881 Gamma-aminobutyraldehyde dehydrogenase prr 0.0026
2336 2,3-diketo-L-gulonate reductase dlgD 0.0026
2018 Deoxyhypusine synthase DHPS 0.0026
4200 Cytochrome P450 1A2 CYP1A2 0.0026
6026 Alcohol dehydrogenase 6 ADH6 0.0025
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0025
2683 Mono-ADP-ribosyltransferase C3 C3 0.0025
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0025
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0025
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0025
626 Cysteine dioxygenase type 1 CDO1 0.0025
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0025
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0025
627 11-cis retinol dehydrogenase RDH5 0.0025
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0025
13 Aminomethyltransferase, mitochondrial AMT 0.0025
4504 WbpP Not Available 0.0025
3296 Nicotinamide mononucleotide adenylyltransferase 1 NMNAT1 0.0024
3367 GDP-mannose 6-dehydrogenase algD 0.0024
63 Malate dehydrogenase mdh 0.0024
2329 Malate dehydrogenase mdh 0.0024
3445 Malate dehydrogenase mdh 0.0024
4420 Malate dehydrogenase mdh 0.0024
4438 Malate dehydrogenase mdh 0.0024
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0024
4476 Mannitol dehydrogenase mtlD 0.0024
4440 NADH peroxidase npr 0.0024
4318 Siroheme synthase cysG 0.0024
4343 Alpha-glucosidase aglA 0.0024
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0024
2799 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Not Available 0.0024
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0023
2617 Nitric oxide synthase oxygenase nos 0.0023
2701 Nitric oxide synthase oxygenase nos 0.0023
3333 Nicotinamide mononucleotide adenylyltransferase 3 NMNAT3 0.0023
327 Glutathione reductase gor 0.0023
5110 Glutathione reductase GR2 0.0023
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0023
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0023
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0023
2826 Glucose--fructose oxidoreductase gfo 0.0023
3070 Adenosylhomocysteinase AHCY 0.0023
4424 Adenosylhomocysteinase PFE1050w 0.0023
6278 Adenosylhomocysteinase ahcY 0.0023
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0022
3191 Histidinol dehydrogenase hisD 0.0022
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0022
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0021
810 Heme oxygenase 1 HMOX1 0.0021
3391 Heme oxygenase 1 pbsA1 0.0021
279 Tyrosinase TYR 0.0021
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0021
4491 DNA ligase, NAD-dependent ligA 0.002
2762 UDP-glucose 4-epimerase GALE 0.002
3461 UDP-glucose 4-epimerase galE 0.002
380 Cytochrome P450 17A1 CYP17A1 0.002
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.002
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0018
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0018
5582 Regulator of transcription; stringent starvation protein A sspA 0.0018
4238 50S ribosomal protein L4 rplD 0.0018
5578 50S ribosomal protein L4 rplD 0.0018
6173 50S ribosomal protein L4 rplD 0.0018
6219 50S ribosomal protein L4 rplD 0.0018
5590 N utilization substance protein B homolog nusB 0.0018
5588 Cell division protein FtsY TM_0570 0.0018
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0018
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0018
2300 Lysozyme E 0.0018
3633 Lysozyme R 0.0018
5597 Lysozyme 17 0.0018
5587 Iron(III)-binding periplasmic protein fbpA 0.0018
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0018
5591 Complement component C8 gamma chain C8G 0.0018
2838 Ribose-5-phosphate isomerase A rpiA 0.0018
2952 Ribose-5-phosphate isomerase A rpiA 0.0018
5595 Ribose-5-phosphate isomerase A rpiA 0.0018
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.0018
5593 Transferase Not Available 0.0018
4695 UPF0124 protein yfiH yfiH 0.0018
5060 Intron-associated endonuclease 1 ITEVIR 0.0018
4375 Glutamine synthetase 1 glnA1 0.0018
5575 Short tail fiber protein 12 0.0018
5581 Beta-fructosidase bfrA 0.0018
5600 Pyruvate decarboxylase pdc 0.0018
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0018
5580 Hexon protein PII 0.0017
5574 Invasin YPTB1668 0.0017
468 Cytochrome P450 4A11 CYP4A11 0.0017
6020 Aldehyde oxidase AOX1 0.0017
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0016
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0016
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0016
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0016
4992 Cytochrome c peroxidase Not Available 0.0015
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0015
3132 Tryptophan synthase alpha chain trpA 0.0015
6568 Tryptophan synthase alpha chain trpA 0.0015
5006 RNASE4 protein RNASE4 0.0015
4533 Glyoxalase family protein BC_1747 0.0015
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0015
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0015
2555 Pol polyprotein pol 0.0015
3242 Pol polyprotein gag-pol 0.0015
3471 Pol polyprotein gag-pro-pol 0.0015
5256 Pol polyprotein pol 0.0015
6469 Pol polyprotein gag-pol 0.0015
6565 Pol polyprotein Not Available 0.0015
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0015
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.0014
2521 Cell division protein ftsZ ftsZ 0.0014
3301 Cell division protein ftsZ ftsZ 0.0014
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0014
2149 Angiogenin ANG 0.0014
2603 Beta-lactamase II blm 0.0014
3583 6-phosphogluconolactonase pgl 0.0014
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0013
3486 Fumarate hydratase class II fumC 0.0013
2942 Sialidase nanH 0.0013
3546 Sialidase nedA 0.0013
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.0013
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.0013
1123 Eosinophil cationic protein RNASE3 0.0012
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0012
332 Beta-lactamase blaZ 0.0012
2478 Beta-lactamase ampC 0.0012
2613 Beta-lactamase ampC 0.0012
2635 Beta-lactamase ampC 0.0012
2700 Beta-lactamase penP 0.0012
5445 Beta-lactamase blaB 0.0012
6019 Beta-lactamase SHV-7 0.0012
6701 Beta-lactamase cphA 0.0012
2697 Uridine-cytidine kinase 2 UCK2 0.0012
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0012
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0012
2452 Tryptophanyl-tRNA synthetase trpS 0.0012
5579 Carboxypeptidase B CPB1 0.0012
3384 Macrophage migration inhibitory factor MIF 0.0011
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0011
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0011
411 Glycine N-methyltransferase GNMT 0.0011
128 Adenine phosphoribosyltransferase APRT 0.001
5682 Ribonuclease pancreatic RNASE1 0.0009
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0009
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0008
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0007
↑