DT-Web

DB04478 - Cp-166572, 2-Hydroxymethyl-4-(4-N,N-Dimethylaminosulfonyl-1-Piperazino)-Pyrimidine


Identification
Name Cp-166572, 2-Hydroxymethyl-4-(4-N,N-Dimethylaminosulfonyl-1-Piperazino)-Pyrimidine
Accession Number DB04478 (EXPT00235)
Type small molecule
Description Not Available
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 301.365
Groups experimental
Monoisotopic Weight 301.120860189
Pharmacology
Indication Not Available
Mechanism of action Not Available
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms Not Available
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Sorbitol dehydrogenase
Name Sorbitol dehydrogenase
Gene Name SORD
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.6249

Predictions


Id Partner name Gene Name Score
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0079
816 Biliverdin reductase A BLVRA 0.0079
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0079
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0079
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.0073
646 Malate dehydrogenase, cytoplasmic MDH1 0.0073
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0073
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0073
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.0073
597 Dihydropteridine reductase QDPR 0.0071
396 Alcohol dehydrogenase 4 ADH4 0.0071
363 NADP-dependent malic enzyme, mitochondrial ME3 0.0071
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.0069
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0068
77 L-lactate dehydrogenase B chain LDHB 0.0067
12 Alcohol dehydrogenase class 3 ADH5 0.0067
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0066
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0066
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0066
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0066
473 L-lactate dehydrogenase A chain LDHA 0.0064
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0064
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0063
569 Retinal dehydrogenase 2 ALDH1A2 0.0062
166 NAD-dependent malic enzyme, mitochondrial ME2 0.006
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.006
611 Retinal dehydrogenase 1 ALDH1A1 0.0059
251 Alcohol dehydrogenase 1A ADH1A 0.0058
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0057
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0054
444 Alcohol dehydrogenase 1B ADH1B 0.0053
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.005
4497 Benzyl alcohol dehydrogenase xylB 0.005
4428 Redox-sensing transcriptional repressor rex rex 0.005
4449 ADP-ribosyltransferase Not Available 0.005
2350 3-isopropylmalate dehydrogenase leuB 0.005
3092 3-isopropylmalate dehydrogenase leuB 0.005
4495 3-oxoacyl-(Acyl carrier protein) reductase TM_1169 0.005
3735 NAD(P) transhydrogenase subunit alpha part 1 pntAA 0.005
4466 Glutathione-independent formaldehyde dehydrogenase fdhA 0.005
4446 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase Not Available 0.005
4472 Glucose 1-dehydrogenase Not Available 0.005
4423 Levodione reductase lvr 0.005
4487 Transcriptional regulator nadR nadR 0.005
3729 Citrate synthase gltA 0.005
4575 Citrate synthase cit 0.005
4580 Citrate synthase gltA 0.005
4505 Cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase bphB 0.005
4451 Vip2Ac vip2Ac 0.005
4443 Quinate/shikimate dehydrogenase ydiB 0.005
4456 Inorganic polyphosphate/ATP-NAD kinase ppnK 0.005
4500 L-lactate dehydrogenase 2 ldh2 0.005
3381 Alcohol dehydrogenase Not Available 0.005
4508 Alcohol dehydrogenase adhA 0.005
4447 Hypothetical protein yhfP yhfP 0.005
4336 Glyceraldehyde 3-phosphate dehydrogenase Not Available 0.005
4436 Glyceraldehyde 3-phosphate dehydrogenase tthHB8IM 0.005
4414 Dehydrogenase TT_P0035 0.005
4471 CDP-D-glucose-4,6-dehydratase ascB 0.005
4418 AGR_L_3209p AGR_L_3209 0.005
4507 Alanine dehydrogenase ald 0.005
4475 Hypothetical protein Rv0046c/MT0052 ino1 0.005
4455 Glycerol dehydrogenase gldA 0.005
4502 Formate dehydrogenase Not Available 0.005
4435 L-aspartate dehydrogenase nadX 0.005
4506 Myo-inositol-1-phosphate synthase-related protein TM_1419 0.005
4448 L-2-hydroxyisocaproate dehydrogenase Not Available 0.005
4467 Alpha-glucosidase, putative TM_0752 0.005
714 Glutathione reductase, mitochondrial GSR 0.005
517 Alcohol dehydrogenase 1C ADH1C 0.0047
4484 2,5-diketo-D-gluconic acid reductase A dkgA 0.0042
4486 Phenol 2-hydroxylase component B pheA2 0.0042
4439 Ferredoxin reductase bphA4 0.0042
4477 Dihydrolipoyl dehydrogenase lpdV 0.0042
5077 Dihydrolipoyl dehydrogenase Not Available 0.0042
5117 Dihydrolipoyl dehydrogenase lpd 0.0042
3598 dTDP-4-dehydrorhamnose reductase rfbD 0.0042
4427 TDP-glucose-4,6-dehydratase desIV 0.0042
3177 dTDP-glucose 4,6-dehydratase rfbB 0.0042
4499 dTDP-glucose 4,6-dehydratase rmlB 0.0042
4482 UDP-galactose 4-epimerase galE 0.0042
2967 CDP-paratose 2-epimerase rfbE 0.0042
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.0042
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.0042
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.0042
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.0042
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.0042
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.0042
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.0042
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.0042
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.0042
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.0042
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.0042
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.0041
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.0041
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.0041
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.0041
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.0041
602 Acyl carrier protein, mitochondrial NDUFAB1 0.0041
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.0041
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.0041
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.0041
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.0041
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.0041
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.0041
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.0041
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.0041
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.0041
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.0041
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.0041
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.0041
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.0041
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.0041
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.0041
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.0041
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.0041
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.0041
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.0041
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.0041
644 Heme oxygenase 2 HMOX2 0.0041
4982 Heme oxygenase 2 pbsA2 0.0041
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.0041
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.0041
729 GDP-L-fucose synthetase TSTA3 0.0041
3463 GDP-L-fucose synthetase fcl 0.0041
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.0041
4503 NADPH-flavin oxidoreductase frp 0.0041
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.0041
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.0041
206 3-keto-steroid reductase HSD17B7 0.0041
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.0041
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.0041
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.0041
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.0041
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.0041
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.0041
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.0041
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.0041
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.0041
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.0041
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.0041
662 Fatty aldehyde dehydrogenase ALDH3A2 0.0041
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.0041
711 UDP-glucose 6-dehydrogenase UGDH 0.0041
3672 UDP-glucose 6-dehydrogenase hasB 0.0041
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.0041
107 C-4 methylsterol oxidase SC4MOL 0.0041
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.0041
3726 D-3-phosphoglycerate dehydrogenase serA 0.0041
4291 D-3-phosphoglycerate dehydrogenase serA 0.0041
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.0041
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.0041
167 L-lactate dehydrogenase C chain LDHC 0.0041
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.0041
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.0041
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.0041
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.0041
643 Peroxisomal bifunctional enzyme EHHADH 0.0041
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.0041
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.0041
34 7-dehydrocholesterol reductase DHCR7 0.0041
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.0041
2507 Diphtheria toxin Not Available 0.0041
2538 6-phospho-beta-glucosidase bglT bglT 0.0041
2393 Maltose-6'-phosphate glucosidase glvA 0.0041
4509 Acetoin(diacetyl) reductase budC 0.0041
3081 3-dehydroquinate synthase aroB 0.0041
2591 Urocanate hydratase hutU 0.0041
4450 Iota toxin component Ia Not Available 0.0041
3671 7-alpha-hydroxysteroid dehydrogenase hdhA 0.0041
3615 Dihydrodipicolinate reductase dapB 0.0041
3618 Dihydrodipicolinate reductase dapB 0.0041
4462 Dihydrodipicolinate reductase dapB 0.0041
2424 L-lactate dehydrogenase ldh 0.0041
2641 L-lactate dehydrogenase Not Available 0.0041
4437 L-lactate dehydrogenase ldh 0.0041
4442 L-lactate dehydrogenase ldh 0.0041
126 D-lactate dehydrogenase dld 0.0041
3545 D-lactate dehydrogenase Not Available 0.0041
4510 D-lactate dehydrogenase ldhA 0.0041
6698 Dehydrogenase/reductase SDR family member 4-like 2 DHRS4L2 0.0041
1199 GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1 ART1 0.0041
2831 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase Not Available 0.004
3059 3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase fabG3 0.004
3401 D-2-hydroxyisocaproate dehydrogenase Not Available 0.004
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.004
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.004
2336 2,3-diketo-L-gulonate reductase dlgD 0.004
2018 Deoxyhypusine synthase DHPS 0.004
4496 C-terminal-binding protein 1 CTBP1 0.004
2881 Gamma-aminobutyraldehyde dehydrogenase prr 0.004
4498 Ornithine cyclodeaminase PP3533 0.004
4504 WbpP Not Available 0.0038
2683 Mono-ADP-ribosyltransferase C3 C3 0.0038
3296 Nicotinamide mononucleotide adenylyltransferase 1 NMNAT1 0.0038
3367 GDP-mannose 6-dehydrogenase algD 0.0038
63 Malate dehydrogenase mdh 0.0038
2329 Malate dehydrogenase mdh 0.0038
3445 Malate dehydrogenase mdh 0.0038
4420 Malate dehydrogenase mdh 0.0038
4438 Malate dehydrogenase mdh 0.0038
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.0038
666 NADP-dependent malic enzyme ME1 0.0038
4476 Mannitol dehydrogenase mtlD 0.0038
4440 NADH peroxidase npr 0.0037
4318 Siroheme synthase cysG 0.0037
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0037
4343 Alpha-glucosidase aglA 0.0037
2799 Glyceraldehyde-3-phosphate dehydrogenase, glycosomal Not Available 0.0037
1799 Glucose-6-phosphate 1-dehydrogenase G6PD 0.0036
2630 Glucose-6-phosphate 1-dehydrogenase zwf 0.0036
857 Malate dehydrogenase, mitochondrial MDH2 0.0036
3333 Nicotinamide mononucleotide adenylyltransferase 3 NMNAT3 0.0036
327 Glutathione reductase gor 0.0036
5110 Glutathione reductase GR2 0.0036
2434 NH(3)-dependent NAD(+) synthetase nadE 0.0036
2910 NH(3)-dependent NAD(+) synthetase nadE 0.0036
3217 NH(3)-dependent NAD(+) synthetase nadE 0.0036
2617 Nitric oxide synthase oxygenase nos 0.0035
2701 Nitric oxide synthase oxygenase nos 0.0035
11 NAD(P) transhydrogenase, mitochondrial NNT 0.0035
2826 Glucose--fructose oxidoreductase gfo 0.0035
3070 Adenosylhomocysteinase AHCY 0.0035
4424 Adenosylhomocysteinase PFE1050w 0.0035
6278 Adenosylhomocysteinase ahcY 0.0035
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0035
5325 2,4-dienoyl-CoA reductase, mitochondrial DECR1 0.0035
6026 Alcohol dehydrogenase 6 ADH6 0.0034
3191 Histidinol dehydrogenase hisD 0.0034
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0034
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0034
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0033
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0033
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0033
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0033
627 11-cis retinol dehydrogenase RDH5 0.0033
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0033
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0033
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0033
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.0033
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0033
626 Cysteine dioxygenase type 1 CDO1 0.0033
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0033
13 Aminomethyltransferase, mitochondrial AMT 0.0032
2762 UDP-glucose 4-epimerase GALE 0.0031
3461 UDP-glucose 4-epimerase galE 0.0031
4491 DNA ligase, NAD-dependent ligA 0.0031
2286 Isocitrate dehydrogenase [NADP] icd 0.0031
2302 Isocitrate dehydrogenase [NADP] icd 0.0031
2771 Isocitrate dehydrogenase [NADP] icd 0.0031
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0031
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0031
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.003
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.003
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.003
654 Flavin reductase BLVRB 0.0028
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0028
279 Tyrosinase TYR 0.0028
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0028
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0027
810 Heme oxygenase 1 HMOX1 0.0026
3391 Heme oxygenase 1 pbsA1 0.0026
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0026
380 Cytochrome P450 17A1 CYP17A1 0.0025
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0025
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0025
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0025
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0025
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0024
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0024
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0023
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0023
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0023
468 Cytochrome P450 4A11 CYP4A11 0.0022
6020 Aldehyde oxidase AOX1 0.0022
822 Aldose reductase AKR1B1 0.0021
365 Dihydrofolate reductase DHFR 0.0021
2381 Dihydrofolate reductase DFR1 0.0021
2833 Dihydrofolate reductase Not Available 0.0021
2931 Dihydrofolate reductase folA 0.0021
3544 Dihydrofolate reductase folA 0.0021
3682 Dihydrofolate reductase folA 0.0021
6642 Dihydrofolate reductase folA 0.0021
6756 Dihydrofolate reductase dfrA 0.0021
3947 Xanthine dehydrogenase/oxidase XDH 0.002
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