DT-Web

DB01114 - Chlorpheniramine


Identification
Name Chlorpheniramine
Accession Number DB01114 (APRD00001)
Type small molecule
Description A histamine H1 antagonist used in allergic reactions, hay fever, rhinitis, urticaria, and asthma. It has also been used in veterinary applications. One of the most widely used of the classical antihistaminics, it generally causes less drowsiness and sedation than promethazine. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 274.788
Groups approved
Monoisotopic Weight 274.123676325
Pharmacology
Indication For the treatment of rhinitis, urticaria, allergy, common cold, asthma and hay fever.
Mechanism of action Chlorpheniramine binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine.
Absorption Well absorbed in the gastrointestinal tract.
Protein binding 72%
Biotransformation Primarily hepatic via Cytochrome P450 (CYP450) enzymes.
Route of elimination Not Available
Toxicity Oral LD50 (rat): 306 mg/kg; Oral LD50 (mice): 130 mg/kg; Oral LD50 (guinea pig): 198 mg/kg [Registry of Toxic Effects of Chemical Substances. Ed. D. Sweet, US Dept. of Health & Human Services: Cincinatti, 2010.] Also a mild reproductive toxin to women of childbearing age.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Donepezil Possible antagonism of action
Ethotoin The antihistamine increases the effect of hydantoin
Fosphenytoin The antihistamine increases the effect of hydantoin
Galantamine Possible antagonism of action
Mephenytoin The antihistamine increases the effect of hydantoin
Phenytoin The antihistamine increases the effect of hydantoin
Rivastigmine Possible antagonism of action
Tacrine The therapeutic effects of the central acetylcholinesterase inhibitor, Tacrine, and/or the anticholinergic, Chlorpheniramine, may be reduced due to antagonism. The interaction may be beneficial when the anticholinergic action is a side effect. Monitor for decreased efficacy of both agents.
Telithromycin Telithromycin may reduce clearance of Chlorpheniramine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Chlorpheniramine if Telithromycin is initiated, discontinued or dose changed.
Trimethobenzamide Trimethobenzamide and Chlorpheniramine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Triprolidine Triprolidine and Chlorpheniramine, two anticholinergics, may cause additive anticholinergic effects and enhance their adverse/toxic effects. Additive CNS depressant effects may also occur. Monitor for enhanced anticholinergic and CNS depressant effects.
Trospium Trospium and Chlorpheniramine, two anticholinergics, may cause additive anticholinergic effects and enhanced adverse/toxic effects. Monitor for enhanced anticholinergic effects.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of chlorpheniramine by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of chlorpheniramine if voriconazole is initiated, discontinued or dose changed.
Food Interactions
  • Take with food.
  • Avoid alcohol.

Targets


Histamine H1 receptor
Name Histamine H1 receptor
Gene Name HRH1
Pharmacological action yes
Actions antagonist
References
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Tagawa M, Kano M, Okamura N, Higuchi M, Matsuda M, Mizuki Y, Arai H, Iwata R, Fujii T, Komemushi S, Ido T, Itoh M, Sasaki H, Watanabe T, Yanai K: Neuroimaging of histamine H1-receptor occupancy in human brain by positron emission tomography (PET): a comparative study of ebastine, a second-generation antihistamine, and (+)-chlorpheniramine, a classical antihistamine. Br J Clin Pharmacol. 2001 Nov;52(5):501-9. - Pubmed
  • Salata JJ, Jurkiewicz NK, Wallace AA, Stupienski RF 3rd, Guinosso PJ Jr, Lynch JJ Jr: Cardiac electrophysiological actions of the histamine H1-receptor antagonists astemizole and terfenadine compared with chlorpheniramine and pyrilamine. Circ Res. 1995 Jan;76(1):110-9. - Pubmed
  • Hasenohrl RU, Kuhlen A, Frisch C, Galosi R, Brandao ML, Huston JP: Comparison of intra-accumbens injection of histamine with histamine H1-receptor antagonist chlorpheniramine in effects on reinforcement and memory parameters. Behav Brain Res. 2001 Oct 15;124(2):203-11. - Pubmed
  • Yasuda SU, Wellstein A, Likhari P, Barbey JT, Woosley RL: Chlorpheniramine plasma concentration and histamine H1-receptor occupancy. Clin Pharmacol Ther. 1995 Aug;58(2):210-20. - Pubmed
  • Nicholson AN, Pascoe PA, Turner C, Ganellin CR, Greengrass PM, Casy AF, Mercer AD: Sedation and histamine H1-receptor antagonism: studies in man with the enantiomers of chlorpheniramine and dimethindene. Br J Pharmacol. 1991 Sep;104(1):270-6. - Pubmed
DTHybrid score 0.6
Sodium-dependent serotonin transporter
Name Sodium-dependent serotonin transporter
Gene Name SLC6A4
Pharmacological action unknown
Actions inhibitor
References
  • Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed
DTHybrid score 0.4779
Sodium-dependent noradrenaline transporter
Name Sodium-dependent noradrenaline transporter
Gene Name SLC6A2
Pharmacological action unknown
Actions inhibitor
References
  • Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed
DTHybrid score 0.6342
Sodium-dependent dopamine transporter
Name Sodium-dependent dopamine transporter
Gene Name SLC6A3
Pharmacological action unknown
Actions inhibitor
References
  • Tatsumi M, Groshan K, Blakely RD, Richelson E: Pharmacological profile of antidepressants and related compounds at human monoamine transporters. Eur J Pharmacol. 1997 Dec 11;340(2-3):249-58. - Pubmed
DTHybrid score 0.5806

Enzymes


Cytochrome P450 3A7
Name Cytochrome P450 3A7
Gene Name CYP3A7
Actions substrate
References
DTHybrid score 0.3148
Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
DTHybrid score 0.6798
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • Hamelin BA, Bouayad A, Drolet B, Gravel A, Turgeon J: In vitro characterization of cytochrome P450 2D6 inhibition by classic histamine H1 receptor antagonists. Drug Metab Dispos. 1998 Jun;26(6):536-9. - Pubmed
  • Flockhart DA. - Drug Interactions: Cytochrome P450 Drug Interaction Table
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.6403
Cytochrome P450 3A5
Name Cytochrome P450 3A5
Gene Name CYP3A5
Actions substrate
References
DTHybrid score 0.3898

Transporters


Solute carrier family 22 member 2
Name Solute carrier family 22 member 2
Gene Name SLC22A2
Actions inhibitor
References
  • Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001 Nov;18(11):1528-34. - Pubmed
DTHybrid score 0.2476
Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions inhibitor
References
  • Urakami Y, Okuda M, Masuda S, Akazawa M, Saito H, Inui K: Distinct characteristics of organic cation transporters, OCT1 and OCT2, in the basolateral membrane of renal tubules. Pharm Res. 2001 Nov;18(11):1528-34. - Pubmed
DTHybrid score 0.3031

Predictions


Id Partner name Gene Name Score
1588 Multidrug resistance protein 1 ABCB1 0.3043
6016 Cytochrome P450 2C19 CYP2C19 0.2645
4200 Cytochrome P450 1A2 CYP1A2 0.2534
4757 Cytochrome P450 2C9 CYP2C9 0.2524
6030 Cytochrome P450 2B6 CYP2B6 0.1672
4924 Cytochrome P450 2C8 CYP2C8 0.1664
556 Alpha-1A adrenergic receptor ADRA1A 0.1642
502 5-hydroxytryptamine 2A receptor HTR2A 0.1284
6013 Cytochrome P450 2E1 CYP2E1 0.1198
103 Muscarinic acetylcholine receptor M1 CHRM1 0.1118
318 Alpha-2A adrenergic receptor ADRA2A 0.1089
131 Synaptic vesicular amine transporter SLC18A2 0.101
632 Alpha-1B adrenergic receptor ADRA1B 0.0961
6147 Solute carrier family 22 member 3 SLC22A3 0.0948
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0943
118 Organic cation/carnitine transporter 2 SLC22A5 0.0942
3941 Amine oxidase [flavin-containing] A MAOA 0.0942
590 5-hydroxytryptamine 2C receptor HTR2C 0.0904
6024 Cytochrome P450 1A1 CYP1A1 0.0889
831 D(2) dopamine receptor DRD2 0.0842
3939 Amine oxidase [flavin-containing] B MAOB 0.0829
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0785
320 5-hydroxytryptamine 1A receptor HTR1A 0.0769
766 Beta-2 adrenergic receptor ADRB2 0.0731
5718 Cytochrome P450 2A6 CYP2A6 0.0727
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0712
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0711
587 Serum albumin ALB 0.0683
833 Organic cation/carnitine transporter 1 SLC22A4 0.0664
193 Beta-1 adrenergic receptor ADRB1 0.065
629 Alpha-2B adrenergic receptor ADRA2B 0.0615
23 D(1A) dopamine receptor DRD1 0.0607
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0603
341 5-hydroxytryptamine 3 receptor HTR3A 0.0585
378 Alpha-2C adrenergic receptor ADRA2C 0.0576
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0521
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0516
847 Mu-type opioid receptor OPRM1 0.0515
862 Multidrug resistance-associated protein 1 ABCC1 0.0513
6106 Cytochrome P450 2C18 CYP2C18 0.0509
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0499
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0486
1729 Solute carrier family 22 member 6 SLC22A6 0.0463
436 5-hydroxytryptamine 2B receptor HTR2B 0.0463
220 Sodium channel protein type 5 subunit alpha SCN5A 0.046
6142 Solute carrier family 22 member 8 SLC22A8 0.0426
467 Delta-type opioid receptor OPRD1 0.0413
789 Alpha-1D adrenergic receptor ADRA1D 0.0413
776 Bile salt export pump ABCB11 0.0409
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0403
696 Kappa-type opioid receptor OPRK1 0.0396
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.039
3923 Cholinesterase BCHE 0.0382
638 D(3) dopamine receptor DRD3 0.0376
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0376
20 Prostaglandin G/H synthase 1 PTGS1 0.0372
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0366
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0359
1636 Trace amine-associated receptor 1 TAAR1 0.0344
1656 CYP2B protein CYP2B 0.0344
1898 Cytochrome P450 1B1 CYP1B1 0.0322
432 D(4) dopamine receptor DRD4 0.0311
6031 Cytochrome P450 3A43 CYP3A43 0.0311
6182 Cytochrome P450 2J2 CYP2J2 0.0306
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0304
6143 Solute carrier family 22 member 7 SLC22A7 0.0301
124 Histamine H2 receptor HRH2 0.0298
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0295
474 Acetylcholinesterase ACHE 0.0291
871 Glucocorticoid receptor NR3C1 0.0285
3811 Cytochrome P450 19A1 CYP19A1 0.027
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0267
731 HIV-1 protease HIV-1 protease 0.0266
1341 Histamine H3 receptor HRH3 0.0249
885 5-hydroxytryptamine 1B receptor HTR1B 0.0249
6148 Multidrug resistance-associated protein 7 ABCC10 0.024
1517 Beta-3 adrenergic receptor ADRB3 0.0232
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0227
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0223
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0223
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0219
725 5-hydroxytryptamine 1D receptor HTR1D 0.0214
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0211
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0206
465 Calmodulin CALM1 0.0205
2164 Multidrug resistance-associated protein 4 ABCC4 0.0204
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0201
163 D(1B) dopamine receptor DRD5 0.0197
6432 Transporter snf 0.0196
614 Progesterone receptor PGR 0.0192
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0188
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0184
817 DNA topoisomerase 2-alpha TOP2A 0.0184
136 Estrogen receptor ESR1 0.0184
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0184
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0183
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.018
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.018
716 5-hydroxytryptamine 7 receptor HTR7 0.0171
737 Mineralocorticoid receptor NR3C2 0.017
1024 Solute carrier family 22 member 11 SLC22A11 0.017
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0168
516 Neurotensin receptor type 2 NTSR2 0.0168
1757 Myeloperoxidase MPO 0.0167
4773 Deoxycytidine kinase DCK 0.0166
260 Cytochrome P450 51 ERG11 0.0161
761 Cytochrome P450 51 ERG11 0.0161
3163 Cytochrome P450 51 cyp51 0.0161
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.016
6010 Thiamine transporter 1 SLC19A2 0.0159
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0159
4148 Serine/threonine-protein kinase mTOR MTOR 0.0159
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0156
232 Corticosteroid-binding globulin SERPINA6 0.0156
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0155
756 Sex hormone-binding globulin SHBG 0.0153
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0153
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0153
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0151
4203 Histamine N-methyltransferase HNMT 0.0148
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0147
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0147
1256 5-hydroxytryptamine 6 receptor HTR6 0.0145
175 Thiamin pyrophosphokinase 1 TPK1 0.0142
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0142
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0137
4120 NADPH--cytochrome P450 reductase POR 0.0136
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0134
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0134
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0133
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0133
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0133
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0132
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0131
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.013
477 DNA topoisomerase 4 subunit A parC 0.013
886 DNA topoisomerase 4 subunit A parC 0.013
6226 DNA topoisomerase 4 subunit A parC 0.013
7 Nitric oxide synthase, inducible NOS2 0.0128
404 DNA gyrase subunit A gyrA 0.0128
6224 DNA gyrase subunit A gyrA 0.0128
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0127
94 5-hydroxytryptamine 4 receptor HTR4 0.0127
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0126
672 Prostaglandin F2-alpha receptor PTGFR 0.0125
6137 Multidrug resistance-associated protein 6 ABCC6 0.0123
468 Cytochrome P450 4A11 CYP4A11 0.0122
504 Mast/stem cell growth factor receptor KIT 0.0122
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0121
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0121
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0121
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0119
290 Prostaglandin G/H synthase 2 PTGS2 0.0119
6136 Multidrug resistance-associated protein 5 ABCC5 0.0118
828 Phenylalanine-4-hydroxylase PAH 0.0115
3109 Phenylalanine-4-hydroxylase phhA 0.0115
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0115
723 Cytosolic phospholipase A2 PLA2G4A 0.0113
380 Cytochrome P450 17A1 CYP17A1 0.0112
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.011
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.011
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0109
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0109
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0108
164 Histamine H4 receptor HRH4 0.0106
811 Translocator protein TSPO 0.0106
6141 Sodium/bile acid cotransporter SLC10A1 0.0106
228 Beta platelet-derived growth factor receptor PDGFRB 0.0106
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0103
161 Tubulin beta chain TUBB 0.0101
312 Tubulin beta chain TUB2 0.0101
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0099
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0099
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0099
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0099
904 Glutathione S-transferase P GSTP1 0.0099
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0098
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0098
509 Thymidine kinase TK 0.0097
570 Thymidine kinase TK 0.0097
2559 Thymidine kinase TK 0.0097
3430 Thymidine kinase tdk 0.0097
3518 Thymidine kinase TK 0.0097
5301 Thymidine kinase tdk 0.0097
5771 Thymidine kinase ORF36 0.0097
7009 Thymidine kinase ORF36 0.0097
844 Epidermal growth factor receptor EGFR 0.0096
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0096
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0096
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0096
738 Monocarboxylate transporter 1 SLC16A1 0.0096
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0096
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0096
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0096
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0096
3947 Xanthine dehydrogenase/oxidase XDH 0.0096
818 50S ribosomal protein L10 rplJ 0.0095
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0095
528 5-hydroxytryptamine 1E receptor HTR1E 0.0095
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0095
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0093
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0093
1275 Estrogen sulfotransferase SULT1E1 0.0093
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0093
1618 High affinity nerve growth factor receptor NTRK1 0.0092
153 Dopamine beta-hydroxylase DBH 0.0092
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0092
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0089
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0089
6070 Nischarin NISCH 0.0089
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0089
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0088
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0087
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0087
1770 Phospholipase C PLCL1 0.0087
2841 Phospholipase C plc 0.0087
29 Tubulin beta-1 chain TUBB1 0.0086
694 Matrix protein 2 M 0.0086
338 DNA polymerase UL30 0.0086
379 DNA polymerase UL54 0.0086
697 DNA polymerase ORF28 0.0086
2482 DNA polymerase 43 0.0086
4104 DNA polymerase BALF5 0.0086
952 Dipeptidyl peptidase 4 DPP4 0.0084
1830 5'-nucleotidase NT5E 0.0084
768 FK506-binding protein 1A FKBP1A 0.0083
146 Androgen receptor AR 0.0082
1360 Sphingomyelin phosphodiesterase SMPD1 0.0082
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0082
2472 Voltage-gated potassium channel kcsA 0.0081
6366 Voltage-gated potassium channel kcsA 0.0081
6220 Aryl hydrocarbon receptor AHR 0.0081
125 DNA polymerase beta POLB 0.0081
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.008
976 Platelet glycoprotein IX GP9 0.008
869 Estrogen receptor beta ESR2 0.008
407 Vascular endothelial growth factor receptor 2 KDR 0.008
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0079
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0079
26 Vascular endothelial growth factor receptor 3 FLT4 0.0079
4604 Liver carboxylesterase 1 CES1 0.0078
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0077
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0077
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0076
6014 Cytochrome P450 2A13 CYP2A13 0.0076
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0076
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0075
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0075
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0075
32 Vascular endothelial growth factor receptor 1 FLT1 0.0075
6020 Aldehyde oxidase AOX1 0.0075
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0074
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0074
208 DNA-directed RNA polymerase beta' chain rpoC 0.0074
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0074
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0073
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0072
1010 Cytochrome P450 51A1 CYP51A1 0.0072
705 Glutamate receptor 1 GRIA1 0.0072
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0071
3611 Cytidine deaminase cdd 0.0071
3707 Cytidine deaminase cdd 0.0071
4211 Cytidine deaminase CDA 0.0071
174 Sigma 1-type opioid receptor SIGMAR1 0.0071
6171 Solute carrier family 28 member 3 SLC28A3 0.007
2112 Toll-like receptor 9 TLR9 0.0069
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0068
4237 50S ribosomal protein L22 rplV 0.0068
319 Opioid receptor, sigma 1 OPRS1 0.0067
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0067
3560 Gentamicin 3'-acetyltransferase aacC1 0.0067
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0066
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0066
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0065
5126 Arginase rocF 0.0064
427 Substance-P receptor TACR1 0.0064
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0062
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0062
814 Ryanodine receptor 1 RYR1 0.0061
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.006
6097 Protein S100-A2 S100A2 0.006
1810 Protein S100-A1 S100A1 0.006
165 FL cytokine receptor FLT3 0.006
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.006
777 Tumor necrosis factor TNF 0.006
482 Glycine receptor subunit alpha-1 GLRA1 0.006
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0059
2539 Tubulin alpha-1 chain TUBA4A 0.0059
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0059
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0059
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0059
1864 RET proto-oncogene RET 0.0059
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0058
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0058
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0058
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0058
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0058
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0058
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0058
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0058
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0058
6111 DNA polymerase epsilon subunit 4 POLE4 0.0058
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0058
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0058
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0058
6112 DNA polymerase epsilon subunit 3 POLE3 0.0058
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0058
6110 DNA polymerase epsilon subunit 2 POLE2 0.0058
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0058
740 Argininosuccinate synthase ASS1 0.0058
865 Argininosuccinate synthase ASS1 0.0058
2680 Argininosuccinate synthase argG 0.0058
3194 Argininosuccinate synthase argG 0.0058
6146 High affinity copper uptake protein 1 SLC31A1 0.0056
122 P2Y purinoceptor 12 P2RY12 0.0056
1050 Bile salt sulfotransferase SULT2A1 0.0055
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0055
1629 Transcription factor AP-1 JUN 0.0055
6506 Stathmin-4 STMN4 0.0055
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0054
1852 Microtubule-associated protein 2 MAP2 0.0054
4238 50S ribosomal protein L4 rplD 0.0054
5578 50S ribosomal protein L4 rplD 0.0054
6173 50S ribosomal protein L4 rplD 0.0054
6219 50S ribosomal protein L4 rplD 0.0054
908 Glutathione S-transferase theta-1 GSTT1 0.0054
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0053
3810 Catechol O-methyltransferase COMT 0.0053
1048 Protein S100-A13 S100A13 0.0052
2226 Protein S100-A12 S100A12 0.0052
469 Annexin A1 ANXA1 0.0051
624 Guanidinoacetate N-methyltransferase GAMT 0.005
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
5251 Carbonyl reductase [NADPH] 1 CBR1 0.005
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.005
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.005
6102 Arylamine N-acetyltransferase 2 NAT2 0.005
2449 Tubulin alpha-3 chain TUBA1A 0.0049
2132 Protein S100-B S100B 0.0049
173 Toll-like receptor 7 TLR7 0.0049
6165 Copper-transporting ATPase 1 ATP7A 0.0049
6163 Copper-transporting ATPase 2 ATP7B 0.0049
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0049
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0049
1483 Membrane copper amine oxidase AOC3 0.0048
5923 Microtubule-associated protein tau MAPT 0.0048
5924 Microtubule-associated protein 4 MAP4 0.0048
1178 Adenosine A2a receptor ADORA2A 0.0047
295 Carbonic anhydrase 1 CA1 0.0047
2300 Lysozyme E 0.0047
3633 Lysozyme R 0.0047
5597 Lysozyme 17 0.0047
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0047
896 Glutathione S-transferase Mu 1 GSTM1 0.0046
565 Extracellular calcium-sensing receptor CASR 0.0046
3086 Plasmepsin-2 Not Available 0.0046
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0046
2981 Phospholipase A2, membrane associated PLA2G2A 0.0045
751 Potassium channel subfamily K member 6 KCNK6 0.0045
303 Diamine acetyltransferase 2 SAT2 0.0045
623 Spermine oxidase SMOX 0.0045
1317 Spermine synthase SMS 0.0045
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0045
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0045
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0045
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0045
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0045
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0044
342 P protein [Includes: DNA-directed DNA polymerase P 0.0044
612 P protein [Includes: DNA-directed DNA polymerase P 0.0044
6211 Tubulin epsilon chain TUBE1 0.0044
6212 Tubulin gamma-1 chain TUBG1 0.0044
6210 Tubulin delta chain TUBD1 0.0044
603 DNA polymerase alpha catalytic subunit POLA1 0.0043
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0043
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.0043
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0042
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0042
273 Apoptosis regulator Bcl-2 BCL2 0.0042
6167 Organic solute transporter subunit beta OSTB 0.0042
6166 Organic solute transporter subunit alpha OSTA 0.0042
1196 Complement decay-accelerating factor CD55 0.0042
172 Potassium channel subfamily K member 1 KCNK1 0.0041
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0041
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0041
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0041
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0041
3932 Glutathione S-transferase A2 GSTA2 0.0041
284 DNA-directed RNA polymerase beta chain rpoB 0.0041
5773 DNA-directed RNA polymerase beta chain rpoB 0.0041
84 Nuclear receptor 0B1 NR0B1 0.0041
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0041
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
856 Vitamin D3 receptor VDR 0.004
123 Diamine acetyltransferase 1 SAT1 0.004
16 Adenosine A1 receptor ADORA1 0.0039
239 Coagulation factor X F10 0.0039
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0039
2268 Cholesterol oxidase choB 0.0039
2822 Cholesterol oxidase choA 0.0039
4192 DNA topoisomerase 2-beta TOP2B 0.0039
4122 Histone deacetylase 2 HDAC2 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
592 Carbonic anhydrase 4 CA4 0.0038
5626 Nucleoside diphosphate kinase B NME2 0.0038
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0038
70 Type-1 angiotensin II receptor AGTR1 0.0038
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0038
702 UMP-CMP kinase CMPK1 0.0037
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0037
1525 Heparin-binding growth factor 2 FGF2 0.0037
891 Dihydropteroate synthase folP 0.0037
5359 Dihydropteroate synthase folP 0.0037
7175 Dihydropteroate synthase sulI 0.0037
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0037
2283 Steroid Delta-isomerase ksi 0.0037
2920 Steroid Delta-isomerase ksi 0.0037
527 Prostacyclin receptor PTGIR 0.0036
2808 Chloramphenicol acetyltransferase 3 cat3 0.0036
54 Prothrombin F2 0.0036
5682 Ribonuclease pancreatic RNASE1 0.0036
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0036
3926 Choline transporter-like protein 2 SLC44A2 0.0036
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0036
1686 Choline transporter-like protein 1 SLC44A1 0.0036
3927 Choline transporter-like protein 3 SLC44A3 0.0036
861 Choline kinase alpha CHKA 0.0036
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0036
3925 Choline transporter-like protein 4 SLC44A4 0.0036
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0036
769 High-affinity choline transporter 1 SLC5A7 0.0036
700 Choline dehydrogenase, mitochondrial CHDH 0.0036
576 Choline O-acetyltransferase CHAT 0.0036
3922 Phospholipase D2 PLD2 0.0036
3924 Phospholipase D1 PLD1 0.0036
68 Cannabinoid receptor 1 CNR1 0.0036
1074 Urokinase-type plasminogen activator PLAU 0.0036
5300 Antigen peptide transporter 1 TAP1 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
6085 Fatty acid-binding protein, intestinal FABP2 0.0035
939 50S ribosomal protein L3 rplC 0.0035
1630 Integrin beta-2 ITGB2 0.0035
6217 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8B PDE8B 0.0035
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0034
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0034
373 Transthyretin TTR 0.0033
4311 tRNA TRDMT1 0.0033
4325 tRNA trmD 0.0033
4328 tRNA trmD 0.0033
3601 Dihydropteroate synthase 1 folP1 0.0033
3807 Dihydropteroate synthase 1 folP1 0.0033
3808 Dihydropteroate synthase 2 folP2 0.0033
2417 Chloramphenicol acetyltransferase cat 0.0033
3278 Chloramphenicol acetyltransferase cat 0.0033
277 Purine nucleoside phosphorylase PNP 0.0033
2870 Purine nucleoside phosphorylase punA 0.0033
2945 Purine nucleoside phosphorylase punA 0.0033
4659 Purine nucleoside phosphorylase TM_1596 0.0033
4825 Purine nucleoside phosphorylase TTHA1435 0.0033
6218 Pannexin-1 PANX1 0.0033
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0033
2251 Thymidylate kinase tmk 0.0033
2254 Thymidylate kinase DTYMK 0.0033
3522 Thymidylate kinase tmk 0.0033
2810 Dr hemagglutinin structural subunit draA 0.0032
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0032
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0032
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0032
33 Cystine/glutamate transporter SLC7A11 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
2257 Uridine phosphorylase udp 0.0031
5132 Uridine phosphorylase udp 0.0031
449 Ornithine decarboxylase ODC1 0.0031
3913 Glutamic acid decarboxylase GAD65 0.0031
365 Dihydrofolate reductase DHFR 0.0031
2381 Dihydrofolate reductase DFR1 0.0031
2833 Dihydrofolate reductase Not Available 0.0031
2931 Dihydrofolate reductase folA 0.0031
3544 Dihydrofolate reductase folA 0.0031
3682 Dihydrofolate reductase folA 0.0031
6642 Dihydrofolate reductase folA 0.0031
6756 Dihydrofolate reductase dfrA 0.0031
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0031
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
5294 Nucleoside diphosphate kinase A NME1 0.003
6216 High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A PDE8A 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
1353 DNA topoisomerase 1 TOP1 0.003
3552 DNA topoisomerase 1 topA 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
80 Peroxisome proliferator-activated receptor alpha PPARA 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
6043 Putative G-protein coupled receptor 44 GPR44 0.003
6048 Troponin C, skeletal muscle TNNC2 0.0029
823 Fibroblast growth factor receptor 2 FGFR2 0.0029
691 cAMP-specific 3',5'-cyclic phosphodiesterase 7B PDE7B 0.0029
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0029
6149 Solute carrier family 22 member 10 SLC22A10 0.0029
357 Carbonic anhydrase 2 CA2 0.0029
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0029
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0028
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0028
4217 Telomerase reverse transcriptase TERT 0.0028
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0028
6044 Serum paraoxonase/lactonase 3 PON3 0.0028
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0028
3856 Fibroblast growth factor receptor 3 FGFR3 0.0028
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0028
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
780 Retinoic acid receptor RXR-gamma RXRG 0.0027
1192 Sulfotransferase 1A1 SULT1A1 0.0027
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0027
4228 Keratin, type II cytoskeletal 7 KRT7 0.0027
779 High-affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A PDE7A 0.0026
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0026
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0026
3904 Alanine aminotransferase 2 GPT2 0.0026
735 Alanine aminotransferase 1 GPT 0.0026
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0026
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0026
572 Integrin alpha-L ITGAL 0.0026
49 Endothelin B receptor EDNRB 0.0026
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0025
275 Arachidonate 5-lipoxygenase ALOX5 0.0025
88 Retinoic acid receptor RXR-beta RXRB 0.0024
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
719 Retinoic acid receptor responder protein 1 RARRES1 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
770 Retinoic acid-induced protein 3 GPRC5A 0.0024
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0023
5934 Cytochrome P450 26A1 CYP26A1 0.0023
543 Penicillin-binding protein 1B mrcB 0.0023
6186 Penicillin-binding protein 1B ponB 0.0023
6822 Penicillin-binding protein 1b pbp1b 0.0023
6844 Penicillin-binding protein 1b pbp1b 0.0023
6151 Monocarboxylate transporter 10 SLC16A10 0.0023
6174 50S ribosomal protein L32 rpmF 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
5787 Angiopoietin-1 receptor TEK 0.0022
159 Penicillin-binding protein 2B penA 0.0022
6121 Penicillin-binding protein 2B penA 0.0022
581 Cytochrome P450 2R1 CYP2R1 0.0022
3404 Exotoxin A eta 0.0022
6824 Tyrosine-protein kinase Lyn LYN 0.0022
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0022
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0022
2320 Thymidine kinase, cytosolic TK1 0.0021
298 Renin REN 0.0021
569 Retinal dehydrogenase 2 ALDH1A2 0.0021
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0021
267 Plasminogen activator inhibitor 1 SERPINE1 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
489 Monocarboxylate transporter 2 SLC16A7 0.0021
6126 Carbonic anhydrase 7 CA7 0.002
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.002
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.002
2216 Fibroblast growth factor receptor 4 FGFR4 0.002
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.002
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.002
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.002
611 Retinal dehydrogenase 1 ALDH1A1 0.0019
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0019
2499 Tubulin beta-2C chain TUBB2C 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0019
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0019
3809 Estrogen-related receptor gamma ESRRG 0.0018
6221 Steroid hormone receptor ERR1 ESRRA 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
5998 Toll-like receptor 8 TLR8 0.0018
921 Glutamate receptor 2 GRIA2 0.0018
712 Tubulin alpha chain TUB1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
683 Potassium transporter GK0582 0.0018
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
537 ATP synthase delta chain, mitochondrial ATP5D 0.0017
613 Atrial natriuretic peptide receptor A NPR1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0017
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0017
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0017
518 Peroxidase/catalase T katG 0.0017
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0016
144 Hemoglobin subunit alpha HBA1 0.0016
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0016
3233 Bile acid receptor NR1H4 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
6138 Multidrug resistance protein 3 ABCB4 0.0015
563 Thyroid peroxidase TPO 0.0015
162 Retinoic acid receptor gamma-1 RARG 0.0015
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0015
1541 Metalloproteinase mmp20 0.0014
634 Squalene monooxygenase SQLE 0.0014
7196 Squalene monooxygenase ERG1 0.0014
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0014
936 Ephrin type-A receptor 2 EPHA2 0.0014
1063 Signal transducer and activator of transcription 5B STAT5B 0.0014
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0014
1262 Corticotropin-lipotropin POMC 0.0014
183 Vascular endothelial growth factor A VEGFA 0.0014
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0013
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0013
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0013
244 Angiotensin-converting enzyme ACE 0.0013
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0013
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
1650 Heme carrier protein 1 SLC46A1 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
571 Melatonin receptor type 1A MTNR1A 0.0012
362 Melatonin receptor type 1B MTNR1B 0.0012
3587 Gastrotropin FABP6 0.0012
1295 Fatty acid synthase FASN 0.0012
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0011
484 Tyrosine-protein kinase ABL2 ABL2 0.0011
1992 Vitamin D-binding protein GC 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0011
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0011
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0011
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
4103 Proteasome subunit beta type 2 PSMB2 0.001
4102 Proteasome subunit beta type 5 PSMB5 0.001
4101 Proteasome subunit beta type 1 PSMB1 0.001
3937 Fatty-acid amide hydrolase FAAH 0.001
4116 Dihydropteroate synthetase Not Available 0.001
1374 Natriuretic peptides B NPPB 0.001
1827 Gap junction alpha-1 protein GJA1 0.001
1908 Vascular cell adhesion protein 1 VCAM1 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
2450 Tyrosine-protein kinase ITK/TSK ITK 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
512 DNA-directed RNA polymerase alpha chain rpoA 0.001
5772 DNA-directed RNA polymerase alpha chain rpoA 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
511 5-hydroxytryptamine 1F receptor HTR1F 0.001
605 Fumarate reductase flavoprotein subunit frdA 0.001
2709 Fumarate reductase flavoprotein subunit SO_0970 0.001
3673 Fumarate reductase flavoprotein subunit fccA 0.001
4912 Fumarate reductase flavoprotein subunit ifcA 0.001
6549 Fumarate reductase flavoprotein subunit frdA 0.001
1039 Histone deacetylase 9 HDAC9 0.0009
65 Matrix metalloproteinase-9 Not Available 0.0009
459 Retinoic acid receptor RXR-alpha RXRA 0.0009
1648 Elastin ELN 0.0009
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0009
6131 Carbonic anhydrase 14 CA14 0.0009
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0009
268 Adenosine A2b receptor ADORA2B 0.0009
390 Adenosine A3 receptor ADORA3 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
6122 Carbonic anhydrase 3 CA3 0.0008
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0008
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0008
1867 Major prion protein PRNP 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
2091 Endoplasmin HSP90B1 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
291 Nitric-oxide synthase, endothelial NOS3 0.0007
130 Prostacyclin synthase PTGIS 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
760 Fibroblast growth factor 1 FGF1 0.0007
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0007
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0007
1268 Neuropeptide S receptor NPSR1 0.0007
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0007
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0007
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0007
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0007
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0007
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0007
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0007
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
2298 Cytochrome P450-cam camC 0.0007
24 Thymidylate synthase TMP1 0.0007
359 Thymidylate synthase TYMS 0.0007
2626 Thymidylate synthase thyA 0.0007
2729 Thymidylate synthase thyA 0.0007
5352 Thymidylate synthase THYA 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
6073 Potassium channel subfamily K member 9 KCNK9 0.0006
6072 Potassium channel subfamily K member 3 KCNK3 0.0006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0006
106 Cannabinoid receptor 2 CNR2 0.0006
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0006
3426 Glutamine synthetase glnA 0.0006
3987 Glutamine synthetase GLUL 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0006
3957 Adenosine deaminase ADA 0.0006
6168 Solute carrier family 22 member 16 SLC22A16 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
117 Sterol O-acyltransferase 1 SOAT1 0.0005
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0005
2207 Rhodopsin RHO 0.0005
1714 Mitogen-activated protein kinase 3 MAPK3 0.0005
2236 Casein kinase II subunit alpha CSNK2A1 0.0005
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
76 Nitric-oxide synthase, brain NOS1 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
251 Alcohol dehydrogenase 1A ADH1A 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
820 Glycine receptor subunit alpha-2 GLRA2 0.0003
758 Thyroid hormone receptor alpha THRA 0.0003
444 Alcohol dehydrogenase 1B ADH1B 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0003
5798 Mitogen-activated protein kinase 11 MAPK11 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
517 Alcohol dehydrogenase 1C ADH1C 0.0003
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0003
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0002
3007 Carbonic anhydrase 12 CA12 0.0002
4205 Carbonic anhydrase 9 CA9 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
3116 Bacterioferritin bfr 0.0001
4906 Bacterioferritin bfr 0.0001
4965 Bacterioferritin bfr 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
644 Heme oxygenase 2 HMOX2 0.0001
4982 Heme oxygenase 2 pbsA2 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
3102 Flavohemoprotein hmp 0.0001
4969 Flavohemoprotein hmp 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
3221 Cytochrome c4 cc4 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0
1507 Cytochrome c CYCS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
810 Heme oxygenase 1 HMOX1 0
3391 Heme oxygenase 1 pbsA1 0
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