DT-Web

DB00654 - Latanoprost


Identification
Name Latanoprost
Accession Number DB00654 (APRD01065)
Type small molecule
Description Latanoprost ophthalmic solution is a topical medication used for controlling the progression of glaucoma or ocular hypertension, by reducing intraocular pressure. It is a prostaglandin analogue that works by increasing the outflow of aqueous fluid from the eyes. It is also known by the brand name of Xalatan manufactured by Pfizer.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 432.5928
Groups approved
Monoisotopic Weight 432.28757439
Pharmacology
Indication For the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension.
Mechanism of action Latanoprost is a prostaglandin F2a analogue. Specifically, Latanoprost is a prostanoid selective FP receptor agonist that is believed to reduce the intraocular pressure (IOP) by increasing the outflow of aqueous humor. Studies in animals and man suggest that the main mechanism of action is increased uveoscleral outflow. Elevated IOP represents a major risk factor for glaucomatous field loss. The higher the level of IOP, the greater the likelihood of optic nerve damage and visual field loss.
Absorption Latanoprost is well absorbed through the cornea where the isopropyl ester prodrug is hydrolyzed to the acid form. Peak concentration is reached 2 hrs after topical administration.
Protein binding Not Available
Biotransformation Primarily hepatic (none except hydrolysis in the eye). Latanoprost is an isopropyl ester prodrug. It is hydrolyzed by esterases in the cornea to latanoprost acid, which is biologically active. The portion of the latanoprost acid that reaches the systemic circulation is metabolized primarily by the liver to 1,2-dinor and 1,2,3,4-tetranor metabolites by fatty acid beta-oxidation.
Route of elimination Not Available
Toxicity Symptoms of overdose include bloodshot eyes and eye irritation.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Bimatoprost The concomitant use of bimatoprost and latanoprost may result in increased intraocular pressure. Consider avoiding this combination of therapy. Monitor for paradoxical increases in intraocular pressure during concomitant use.
Food Interactions Not Available

Targets


Prostaglandin F2-alpha receptor
Name Prostaglandin F2-alpha receptor
Gene Name PTGFR
Pharmacological action yes
Actions agonist
References
  • Ota T, Aihara M, Narumiya S, Araie M: The effects of prostaglandin analogues on IOP in prostanoid FP-receptor-deficient mice. Invest Ophthalmol Vis Sci. 2005 Nov;46(11):4159-63. - Pubmed
  • Nakajima T, Matsugi T, Goto W, Kageyama M, Mori N, Matsumura Y, Hara H: New fluoroprostaglandin F(2alpha) derivatives with prostanoid FP-receptor agonistic activity as potent ocular-hypotensive agents. Biol Pharm Bull. 2003 Dec;26(12):1691-5. - Pubmed
  • Takagi Y, Nakajima T, Shimazaki A, Kageyama M, Matsugi T, Matsumura Y, Gabelt BT, Kaufman PL, Hara H: Pharmacological characteristics of AFP-168 (tafluprost), a new prostanoid FP receptor agonist, as an ocular hypotensive drug. Exp Eye Res. 2004 Apr;78(4):767-76. - Pubmed
  • Ocklind A: Effect of latanoprost on the extracellular matrix of the ciliary muscle. A study on cultured cells and tissue sections. Exp Eye Res. 1998 Aug;67(2):179-91. - Pubmed
  • Maxey KM, Johnson JL, LaBrecque J: The hydrolysis of bimatoprost in corneal tissue generates a potent prostanoid FP receptor agonist. Surv Ophthalmol. 2002 Aug;47 Suppl 1:S34-40. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
DTHybrid score 0.7621

Transporters


Solute carrier organic anion transporter family member 2B1
Name Solute carrier organic anion transporter family member 2B1
Gene Name SLCO2B1
Actions substrate
References
  • Kraft ME, Glaeser H, Mandery K, Konig J, Auge D, Fromm MF, Schlotzer-Schrehardt U, Welge-Lussen U, Kruse FE, Zolk O: The prostaglandin transporter OATP2A1 is expressed in human ocular tissues and transports the antiglaucoma prostanoid latanoprost. Invest Ophthalmol Vis Sci. 2010 May;51(5):2504-11. Epub 2009 Dec 17. - Pubmed
DTHybrid score 0.2377
Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions Not Available
References
  • Kimura H, Takeda M, Narikawa S, Enomoto A, Ichida K, Endou H: Human organic anion transporters and human organic cation transporters mediate renal transport of prostaglandins. J Pharmacol Exp Ther. 2002 Apr;301(1):293-8. - Pubmed
DTHybrid score 0.2381

Predictions


Id Partner name Gene Name Score
6144 Solute carrier family 22 member 2 SLC22A2 0.0779
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.075
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0738
290 Prostaglandin G/H synthase 2 PTGS2 0.0703
6142 Solute carrier family 22 member 8 SLC22A8 0.0544
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0529
1588 Multidrug resistance protein 1 ABCB1 0.048
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0472
738 Monocarboxylate transporter 1 SLC16A1 0.0423
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0405
4512 Cytochrome P450 3A4 CYP3A4 0.0378
1729 Solute carrier family 22 member 6 SLC22A6 0.0375
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0374
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0366
4119 Cytochrome P450 2D6 CYP2D6 0.0355
527 Prostacyclin receptor PTGIR 0.035
1024 Solute carrier family 22 member 11 SLC22A11 0.0331
118 Organic cation/carnitine transporter 2 SLC22A5 0.0327
6143 Solute carrier family 22 member 7 SLC22A7 0.0315
4757 Cytochrome P450 2C9 CYP2C9 0.0304
6147 Solute carrier family 22 member 3 SLC22A3 0.0301
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0281
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0278
833 Organic cation/carnitine transporter 1 SLC22A4 0.0266
4200 Cytochrome P450 1A2 CYP1A2 0.0245
862 Multidrug resistance-associated protein 1 ABCC1 0.0243
587 Serum albumin ALB 0.023
4118 Cytochrome P450 3A5 CYP3A5 0.0228
6016 Cytochrome P450 2C19 CYP2C19 0.0223
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0203
4924 Cytochrome P450 2C8 CYP2C8 0.0201
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0186
776 Bile salt export pump ABCB11 0.0175
2164 Multidrug resistance-associated protein 4 ABCC4 0.0172
556 Alpha-1A adrenergic receptor ADRA1A 0.0166
6599 HTH-type transcriptional regulator ttgR ttgR 0.0163
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0163
320 5-hydroxytryptamine 1A receptor HTR1A 0.0147
6107 Cytochrome P450 3A7 CYP3A7 0.0142
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.013
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0128
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0128
831 D(2) dopamine receptor DRD2 0.0128
318 Alpha-2A adrenergic receptor ADRA2A 0.0123
6167 Organic solute transporter subunit beta OSTB 0.0123
6166 Organic solute transporter subunit alpha OSTA 0.0123
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.012
6136 Multidrug resistance-associated protein 5 ABCC5 0.012
23 D(1A) dopamine receptor DRD1 0.0116
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0113
6024 Cytochrome P450 1A1 CYP1A1 0.0112
6030 Cytochrome P450 2B6 CYP2B6 0.0112
502 5-hydroxytryptamine 2A receptor HTR2A 0.0111
500 Monocarboxylate transporter 4 SLC16A3 0.0111
492 Histamine H1 receptor HRH1 0.0105
5650 NimA-related protein DR_0842 0.0098
509 Thymidine kinase TK 0.0097
570 Thymidine kinase TK 0.0097
2559 Thymidine kinase TK 0.0097
3430 Thymidine kinase tdk 0.0097
3518 Thymidine kinase TK 0.0097
5301 Thymidine kinase tdk 0.0097
5771 Thymidine kinase ORF36 0.0097
7009 Thymidine kinase ORF36 0.0097
6141 Sodium/bile acid cotransporter SLC10A1 0.0096
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0095
489 Monocarboxylate transporter 2 SLC16A7 0.0093
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0092
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0092
632 Alpha-1B adrenergic receptor ADRA1B 0.0092
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.009
20 Prostaglandin G/H synthase 1 PTGS1 0.0089
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0088
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0088
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0087
474 Acetylcholinesterase ACHE 0.0086
341 5-hydroxytryptamine 3 receptor HTR3A 0.0083
6013 Cytochrome P450 2E1 CYP2E1 0.0083
766 Beta-2 adrenergic receptor ADRB2 0.0081
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0081
378 Alpha-2C adrenergic receptor ADRA2C 0.008
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.008
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0079
136 Estrogen receptor ESR1 0.0079
860 Nicotinamide N-methyltransferase NNMT 0.0078
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0078
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0078
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0078
699 Nicotinic acid receptor 1 GPR109A 0.0078
928 Nicotinic acid receptor 2 GPR109B 0.0078
6149 Solute carrier family 22 member 10 SLC22A10 0.0078
1792 Tissue-type plasminogen activator PLAT 0.0077
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0077
338 DNA polymerase UL30 0.0073
379 DNA polymerase UL54 0.0073
697 DNA polymerase ORF28 0.0073
2482 DNA polymerase 43 0.0073
4104 DNA polymerase BALF5 0.0073
6010 Thiamine transporter 1 SLC19A2 0.0073
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0073
6148 Multidrug resistance-associated protein 7 ABCC10 0.0072
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0071
629 Alpha-2B adrenergic receptor ADRA2B 0.0069
6106 Cytochrome P450 2C18 CYP2C18 0.0068
3560 Gentamicin 3'-acetyltransferase aacC1 0.0067
175 Thiamin pyrophosphokinase 1 TPK1 0.0066
5718 Cytochrome P450 2A6 CYP2A6 0.0066
193 Beta-1 adrenergic receptor ADRB1 0.0065
1898 Cytochrome P450 1B1 CYP1B1 0.0065
3923 Cholinesterase BCHE 0.0063
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0063
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0061
33 Cystine/glutamate transporter SLC7A11 0.006
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0059
756 Sex hormone-binding globulin SHBG 0.0059
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0059
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0057
4773 Deoxycytidine kinase DCK 0.0057
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0056
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0056
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0054
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0053
124 Histamine H2 receptor HRH2 0.0053
275 Arachidonate 5-lipoxygenase ALOX5 0.0053
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0052
4109 cAMP-specific 3',5'-cyclic phosphodiesterase 4C PDE4C 0.005
6171 Solute carrier family 28 member 3 SLC28A3 0.0049
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0048
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0048
789 Alpha-1D adrenergic receptor ADRA1D 0.0048
731 HIV-1 protease HIV-1 protease 0.0047
6085 Fatty acid-binding protein, intestinal FABP2 0.0047
3014 Ribonuclease UK114 HRSP12 0.0046
3718 Hydrogen peroxide-inducible genes activator oxyR 0.0046
5428 Replication protein repA 0.0046
3617 Non-heme chloroperoxidase cpo 0.0046
5426 Non-heme chloroperoxidase cpo 0.0046
5427 Hydroxyquinol 1,2-dioxygenase chqB 0.0046
3018 HTH-type transcriptional regulator malT malT 0.0046
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0045
303 Diamine acetyltransferase 2 SAT2 0.0045
623 Spermine oxidase SMOX 0.0045
1317 Spermine synthase SMS 0.0045
869 Estrogen receptor beta ESR2 0.0044
6151 Monocarboxylate transporter 10 SLC16A10 0.0044
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.0043
468 Cytochrome P450 4A11 CYP4A11 0.0042
6837 Serine/threonine-protein kinase 17B STK17B 0.0042
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0042
2358 cAMP-specific 3',5'-cyclic phosphodiesterase 4D PDE4D 0.0042
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0041
6070 Nischarin NISCH 0.0041
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0041
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0041
123 Diamine acetyltransferase 1 SAT1 0.004
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.004
540 Sodium-dependent noradrenaline transporter SLC6A2 0.004
2958 Probable tautomerase ydcE pptA 0.004
2573 Cocaine esterase cocE 0.004
7263 Cocaine esterase Not Available 0.004
3939 Amine oxidase [flavin-containing] B MAOB 0.0039
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0039
694 Matrix protein 2 M 0.0039
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0039
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0039
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0039
3115 Ras-related protein Rab-9 RAB9A 0.0039
3603 Chlorocatechol 1,2-dioxygenase clcA 0.0039
2472 Voltage-gated potassium channel kcsA 0.0038
6366 Voltage-gated potassium channel kcsA 0.0038
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0038
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0038
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0037
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0037
3587 Gastrotropin FABP6 0.0037
1830 5'-nucleotidase NT5E 0.0035
824 Sodium-dependent serotonin transporter SLC6A4 0.0034
125 DNA polymerase beta POLB 0.0034
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0034
131 Synaptic vesicular amine transporter SLC18A2 0.0034
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0034
2251 Thymidylate kinase tmk 0.0033
2254 Thymidylate kinase DTYMK 0.0033
3522 Thymidylate kinase tmk 0.0033
2599 Tyrosine-protein kinase HCK HCK 0.0032
828 Phenylalanine-4-hydroxylase PAH 0.0032
3109 Phenylalanine-4-hydroxylase phhA 0.0032
2257 Uridine phosphorylase udp 0.0031
5132 Uridine phosphorylase udp 0.0031
449 Ornithine decarboxylase ODC1 0.0031
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0031
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0031
2021 Thrombomodulin THBD 0.0031
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0031
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.003
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.003
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.003
2693 Heat-labile enterotoxin B chain eltB 0.003
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.003
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.003
3611 Cytidine deaminase cdd 0.003
3707 Cytidine deaminase cdd 0.003
4211 Cytidine deaminase CDA 0.003
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.003
6645 D-amino-acid oxidase DAO 0.0029
5126 Arginase rocF 0.0029
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0029
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0029
713 Sodium-dependent dopamine transporter SLC6A3 0.0029
3811 Cytochrome P450 19A1 CYP19A1 0.0028
3810 Catechol O-methyltransferase COMT 0.0028
1341 Histamine H3 receptor HRH3 0.0028
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0027
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0027
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0027
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0027
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0027
6111 DNA polymerase epsilon subunit 4 POLE4 0.0027
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0027
740 Argininosuccinate synthase ASS1 0.0027
865 Argininosuccinate synthase ASS1 0.0027
2680 Argininosuccinate synthase argG 0.0027
3194 Argininosuccinate synthase argG 0.0027
6112 DNA polymerase epsilon subunit 3 POLE3 0.0027
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0026
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0026
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0026
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0026
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0026
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0026
6110 DNA polymerase epsilon subunit 2 POLE2 0.0026
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0026
164 Histamine H4 receptor HRH4 0.0026
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0026
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0026
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0025
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0025
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0025
3947 Xanthine dehydrogenase/oxidase XDH 0.0025
6031 Cytochrome P450 3A43 CYP3A43 0.0024
163 D(1B) dopamine receptor DRD5 0.0024
3941 Amine oxidase [flavin-containing] A MAOA 0.0023
624 Guanidinoacetate N-methyltransferase GAMT 0.0023
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0023
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0023
5682 Ribonuclease pancreatic RNASE1 0.0023
432 D(4) dopamine receptor DRD4 0.0023
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0023
6220 Aryl hydrocarbon receptor AHR 0.0023
638 D(3) dopamine receptor DRD3 0.0022
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0021
4203 Histamine N-methyltransferase HNMT 0.0021
976 Platelet glycoprotein IX GP9 0.0021
6014 Cytochrome P450 2A13 CYP2A13 0.0021
273 Apoptosis regulator Bcl-2 BCL2 0.0021
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.002
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.002
465 Calmodulin CALM1 0.002
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.002
342 P protein [Includes: DNA-directed DNA polymerase P 0.002
612 P protein [Includes: DNA-directed DNA polymerase P 0.002
603 DNA polymerase alpha catalytic subunit POLA1 0.002
284 DNA-directed RNA polymerase beta chain rpoB 0.002
5773 DNA-directed RNA polymerase beta chain rpoB 0.002
6432 Transporter snf 0.0019
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0019
467 Delta-type opioid receptor OPRD1 0.0019
696 Kappa-type opioid receptor OPRK1 0.0019
847 Mu-type opioid receptor OPRM1 0.0018
5626 Nucleoside diphosphate kinase B NME2 0.0017
702 UMP-CMP kinase CMPK1 0.0017
2300 Lysozyme E 0.0017
3633 Lysozyme R 0.0017
5597 Lysozyme 17 0.0017
1074 Urokinase-type plasminogen activator PLAU 0.0017
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0016
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0016
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0016
1686 Choline transporter-like protein 1 SLC44A1 0.0016
3926 Choline transporter-like protein 2 SLC44A2 0.0016
861 Choline kinase alpha CHKA 0.0016
3927 Choline transporter-like protein 3 SLC44A3 0.0016
769 High-affinity choline transporter 1 SLC5A7 0.0016
700 Choline dehydrogenase, mitochondrial CHDH 0.0016
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0016
3925 Choline transporter-like protein 4 SLC44A4 0.0016
576 Choline O-acetyltransferase CHAT 0.0016
3922 Phospholipase D2 PLD2 0.0016
3924 Phospholipase D1 PLD1 0.0016
952 Dipeptidyl peptidase 4 DPP4 0.0016
6165 Copper-transporting ATPase 1 ATP7A 0.0016
6163 Copper-transporting ATPase 2 ATP7B 0.0016
1864 RET proto-oncogene RET 0.0015
277 Purine nucleoside phosphorylase PNP 0.0015
2870 Purine nucleoside phosphorylase punA 0.0015
2945 Purine nucleoside phosphorylase punA 0.0015
4659 Purine nucleoside phosphorylase TM_1596 0.0015
4825 Purine nucleoside phosphorylase TTHA1435 0.0015
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0015
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0015
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0015
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0015
6146 High affinity copper uptake protein 1 SLC31A1 0.0015
1517 Beta-3 adrenergic receptor ADRB3 0.0015
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0015
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0014
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0014
153 Dopamine beta-hydroxylase DBH 0.0014
908 Glutathione S-transferase theta-1 GSTT1 0.0014
5294 Nucleoside diphosphate kinase A NME1 0.0014
6218 Pannexin-1 PANX1 0.0014
751 Potassium channel subfamily K member 6 KCNK6 0.0014
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0013
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0013
436 5-hydroxytryptamine 2B receptor HTR2B 0.0013
1360 Sphingomyelin phosphodiesterase SMPD1 0.0013
896 Glutathione S-transferase Mu 1 GSTM1 0.0013
3087 Nicotinate-nucleotide adenylyltransferase nadD 0.0013
4469 Nicotinate-nucleotide adenylyltransferase nadD 0.0013
4992 Cytochrome c peroxidase Not Available 0.0013
1618 High affinity nerve growth factor receptor NTRK1 0.0013
172 Potassium channel subfamily K member 1 KCNK1 0.0012
5590 N utilization substance protein B homolog nusB 0.0012
5598 Glycerol uptake operon antiterminator-related protein TM_1436 0.0012
5586 Pleckstrin homology domain-containing family A member 1 PLEKHA1 0.0012
5577 N5-carboxyaminoimidazole ribonucleotide mutase purE 0.0012
3792 KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate aldolase eda 0.0012
2838 Ribose-5-phosphate isomerase A rpiA 0.0012
2952 Ribose-5-phosphate isomerase A rpiA 0.0012
5595 Ribose-5-phosphate isomerase A rpiA 0.0012
4695 UPF0124 protein yfiH yfiH 0.0012
5060 Intron-associated endonuclease 1 ITEVIR 0.0012
5593 Transferase Not Available 0.0012
5588 Cell division protein FtsY TM_0570 0.0012
5591 Complement component C8 gamma chain C8G 0.0012
5587 Iron(III)-binding periplasmic protein fbpA 0.0012
5583 RNA 3'-terminal phosphate cyclase rtcA 0.0012
5582 Regulator of transcription; stringent starvation protein A sspA 0.0012
4238 50S ribosomal protein L4 rplD 0.0012
5578 50S ribosomal protein L4 rplD 0.0012
6173 50S ribosomal protein L4 rplD 0.0012
6219 50S ribosomal protein L4 rplD 0.0012
5592 Ribonucleoside-diphosphate reductase subunit beta nrdF 0.0012
5581 Beta-fructosidase bfrA 0.0012
5600 Pyruvate decarboxylase pdc 0.0012
4375 Glutamine synthetase 1 glnA1 0.0012
5575 Short tail fiber protein 12 0.0012
5580 Hexon protein PII 0.0012
5574 Invasin YPTB1668 0.0012
725 5-hydroxytryptamine 1D receptor HTR1D 0.0012
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0012
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0012
885 5-hydroxytryptamine 1B receptor HTR1B 0.0012
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0012
1757 Myeloperoxidase MPO 0.0012
590 5-hydroxytryptamine 2C receptor HTR2C 0.0011
228 Beta platelet-derived growth factor receptor PDGFRB 0.0011
904 Glutathione S-transferase P GSTP1 0.0011
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0011
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0011
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0011
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0011
380 Cytochrome P450 17A1 CYP17A1 0.0011
1467 Tumor necrosis factor ligand superfamily member 13B TNFSF13B 0.0011
3132 Tryptophan synthase alpha chain trpA 0.0011
6568 Tryptophan synthase alpha chain trpA 0.0011
5006 RNASE4 protein RNASE4 0.0011
2555 Pol polyprotein pol 0.0011
3242 Pol polyprotein gag-pol 0.0011
3471 Pol polyprotein gag-pro-pol 0.0011
5256 Pol polyprotein pol 0.0011
6469 Pol polyprotein gag-pol 0.0011
6565 Pol polyprotein Not Available 0.0011
3085 Molybdopterin-guanine dinucleotide biosynthesis protein A mobA 0.0011
5328 Prostaglandin F synthase Tb11.02.2310 0.0011
4533 Glyoxalase family protein BC_1747 0.0011
3729 Citrate synthase gltA 0.0011
4575 Citrate synthase cit 0.0011
4580 Citrate synthase gltA 0.0011
5599 3-carboxy-cis,cis-muconate cycloisomerase pcaB 0.0011
355 GMP synthase [glutamine-hydrolyzing] GMPS 0.0011
4353 GMP synthase [glutamine-hydrolyzing] guaA 0.0011
504 Mast/stem cell growth factor receptor KIT 0.001
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.001
737 Mineralocorticoid receptor NR3C2 0.001
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.001
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.001
2603 Beta-lactamase II blm 0.001
2521 Cell division protein ftsZ ftsZ 0.001
3301 Cell division protein ftsZ ftsZ 0.001
2149 Angiogenin ANG 0.001
3583 6-phosphogluconolactonase pgl 0.001
857 Malate dehydrogenase, mitochondrial MDH2 0.001
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.001
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.001
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0009
941 Betaine--homocysteine S-methyltransferase 1 BHMT 0.0009
2942 Sialidase nanH 0.0009
3546 Sialidase nedA 0.0009
3486 Fumarate hydratase class II fumC 0.0009
1123 Eosinophil cationic protein RNASE3 0.0009
614 Progesterone receptor PGR 0.0009
332 Beta-lactamase blaZ 0.0009
2478 Beta-lactamase ampC 0.0009
2613 Beta-lactamase ampC 0.0009
2635 Beta-lactamase ampC 0.0009
2700 Beta-lactamase penP 0.0009
5445 Beta-lactamase blaB 0.0009
6019 Beta-lactamase SHV-7 0.0009
6701 Beta-lactamase cphA 0.0009
2869 1-deoxy-D-xylulose 5-phosphate reductoisomerase dxr 0.0009
2286 Isocitrate dehydrogenase [NADP] icd 0.0009
2302 Isocitrate dehydrogenase [NADP] icd 0.0009
2771 Isocitrate dehydrogenase [NADP] icd 0.0009
2452 Tryptophanyl-tRNA synthetase trpS 0.0009
2697 Uridine-cytidine kinase 2 UCK2 0.0009
2805 Heparan sulfate glucosamine 3-O-sulfotransferase 3A1 HS3ST3A1 0.0009
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0009
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0009
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.0009
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0009
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0009
411 Glycine N-methyltransferase GNMT 0.0009
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0009
6137 Multidrug resistance-associated protein 6 ABCC6 0.0008
5579 Carboxypeptidase B CPB1 0.0008
3384 Macrophage migration inhibitory factor MIF 0.0008
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0008
128 Adenine phosphoribosyltransferase APRT 0.0008
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0007
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0007
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0007
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0007
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0007
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0007
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0007
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0007
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0007
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0007
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0007
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0007
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0007
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0007
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0007
146 Androgen receptor AR 0.0007
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0007
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0007
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0007
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0007
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0007
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0007
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0007
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0007
822 Aldose reductase AKR1B1 0.0006
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0006
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0006
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0006
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0006
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0006
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0006
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0006
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0006
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0005
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