DT-Web

DB01621 - Pipotiazine


Identification
Name Pipotiazine
Accession Number DB01621
Type small molecule
Description Pipotiazine has actions similar to those of other phenothiazines. Among the different phenothiazine derivatives, it appears to be less sedating and to have a weak propensity for causing hypotension or potentiating the effects of CNS depressants and anesthetics. However, it produces a high incidence of extra pyramidal reactions. It is used for the maintenance treatment of chronic non-agitated schizophrenic patients. Symptoms of overdose include severe extrapyramidal manifestations, hypotension, lethargy and sedation.
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 475.667
Groups approved
Monoisotopic Weight 475.196333317
Pharmacology
Indication For the maintenance treatment of chronic non-agitated schizophrenic patients.
Mechanism of action Pipotiazine acts as an antagonist (blocking agent) on different postsysnaptic receptors -on dopaminergic-receptors (subtypes D1, D2, D3 and D4 - different antipsychotic properties on productive and unproductive symptoms), on serotonergic-receptors (5-HT1 and 5-HT2, with anxiolytic, antidepressive and antiaggressive properties as well as an attenuation of extrapypramidal side-effects, but also leading to weight gain, fall in blood pressure, sedation and ejaculation difficulties), on histaminergic-receptors (H1-receptors, sedation, antiemesis, vertigo, fall in blood pressure and weight gain), alpha1/alpha2-receptors (antisympathomimetic properties, lowering of blood pressure, reflex tachycardia, vertigo, sedation, hypersalivation and incontinence as well as sexual dysfunction, but may also attenuate pseudoparkinsonism - controversial) and finally on muscarinic (cholinergic) M1/M2-receptors (causing anticholinergic symptoms like dry mouth, blurred vision, obstipation, difficulty/inability to urinate, sinus tachycardia, ECG-changes and loss of memory, but the anticholinergic action may attenuate extrapyramidal side-effects).
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Symptoms of overdose include severe extrapyramidal manifestations, hypotension, lethargy and sedation.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Donepezil Possible antagonism of action
Galantamine Possible antagonism of action
Telithromycin Telithromycin may reduce clearance of Pipotiazine. Consider alternate therapy or monitor for changes in the therapeutic/adverse effects of Pipotiazine if Telithromycin is initiated, discontinued or dose changed.
Terbinafine Terbinafine may reduce the metabolism and clearance of Pipotiazine. Consider alternate therapy or monitor for therapeutic/adverse effects of Pipotiazine if Terbinafine is initiated, discontinued or dose changed.
Triprolidine The antihistamine, Triprolidine, may increase the arrhythmogenic effect of the phenothiazine, Pipotiazine. Monitor for symptoms of ventricular arrhythmias.
Voriconazole Voriconazole, a strong CYP3A4 inhibitor, may increase the serum concentration of pipotiazine by decreasing its metabolism. Monitor for changes in the therapeutic and adverse effects of pipotiazine if voriconazole is initiated, discontinued or dose changed.
Food Interactions
  • Avoid alcohol
  • Take with food to decrease irritation

Targets


D(2) dopamine receptor
Name D(2) dopamine receptor
Gene Name DRD2
Pharmacological action yes
Actions antagonist
References
  • Oades RD, Rao ML, Bender S, Sartory G, Muller BW: Neuropsychological and conditioned blocking performance in patients with schizophrenia: assessment of the contribution of neuroleptic dose, serum levels and dopamine D2-receptor occupancy. Behav Pharmacol. 2000 Jun;11(3-4):317-30. - Pubmed
  • Seeman P: Atypical antipsychotics: mechanism of action. Can J Psychiatry. 2002 Feb;47(1):27-38. - Pubmed
  • Wu S, Xing Q, Gao R, Li X, Gu N, Feng G, He L: Response to chlorpromazine treatment may be associated with polymorphisms of the DRD2 gene in Chinese schizophrenic patients. Neurosci Lett. 2005 Mar 7;376(1):1-4. Epub 2004 Dec 2. - Pubmed
  • Wu SN, Gao R, Xing QH, Li HF, Shen YF, Gu NF, Feng GY, He L: Association of DRD2 polymorphisms and chlorpromazine-induced extrapyramidal syndrome in Chinese schizophrenic patients. Acta Pharmacol Sin. 2006 Aug;27(8):966-70. - Pubmed
  • Chen X, Ji ZL, Chen YZ: TTD: Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5. - Pubmed
  • Seeman P: Dopamine D2 receptors as treatment targets in schizophrenia. Clin Schizophr Relat Psychoses. 2010 Apr;4(1):56-73. - Pubmed
  • Boireau A, Chambry J, Dubedat P, Farges G, Carruette AM, Zundel JL, Blanchard JC: Enhancing effect of dopamine blockers on evoked acetylcholine release in rat striatal slices: a classical D-2 antagonist response? Eur J Pharmacol. 1986 Aug 22;128(1-2):93-8. - Pubmed
DTHybrid score 0.499
D(1A) dopamine receptor
Name D(1A) dopamine receptor
Gene Name DRD1
Pharmacological action yes
Actions antagonist
References
  • Kanba S, Suzuki E, Nomura S, Nakaki T, Yagi G, Asai M, Richelson E: Affinity of neuroleptics for D1 receptor of human brain striatum. J Psychiatry Neurosci. 1994 Jul;19(4):265-9. - Pubmed
DTHybrid score 0.3837
5-hydroxytryptamine 2A receptor
Name 5-hydroxytryptamine 2A receptor
Gene Name HTR2A
Pharmacological action yes
Actions antagonist
References
  • Kusumi I, Takahashi Y, Suzuki K, Kameda K, Koyama T: Differential effects of subchronic treatments with atypical antipsychotic drugs on dopamine D2 and serotonin 5-HT2A receptors in the rat brain. J Neural Transm. 2000;107(3):295-302. - Pubmed
  • Yamada J, Sugimoto Y, Horisaka K: Serotonin2 (5-HT2) receptor agonist 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) inhibits chlorpromazine- and haloperidol-induced hypothermia in mice. Biol Pharm Bull. 1995 Nov;18(11):1580-3. - Pubmed
DTHybrid score 0.4134
5-hydroxytryptamine 1A receptor
Name 5-hydroxytryptamine 1A receptor
Gene Name HTR1A
Pharmacological action yes
Actions antagonist
References
  • Cosi C, Koek W: Agonist, antagonist, and inverse agonist properties of antipsychotics at human recombinant 5-HT(1A) receptors expressed in HeLa cells. Eur J Pharmacol. 2001 Dec 14;433(1):55-62. - Pubmed
  • Newman-Tancredi A, Gavaudan S, Conte C, Chaput C, Touzard M, Verriele L, Audinot V, Millan MJ: Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a [35S]GTPgammaS binding study. Eur J Pharmacol. 1998 Aug 21;355(2-3):245-56. - Pubmed
DTHybrid score 0.3399

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate
References
  • -
  • Wojcikowski J, Boksa J, Daniel WA: Main contribution of the cytochrome P450 isoenzyme 1A2 (CYP1A2) to N-demethylation and 5-sulfoxidation of the phenothiazine neuroleptic chlorpromazine in human liver--A comparison with other phenothiazines. Biochem Pharmacol. 2010 Oct 15;80(8):1252-9. Epub 2010 Jul 6. - Pubmed
DTHybrid score 0.6279
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions substrate,inhibitor
References
  • -
  • Zhou SF: Polymorphism of human cytochrome P450 2D6 and its clinical significance: part II. Clin Pharmacokinet. 2009;48(12):761-804. doi: 10.2165/11318070-000000000-00000. - Pubmed
  • Bhoopathy S, Xin B, Unger SE, Karnes HT: A novel incubation direct injection LC/MS/MS technique for in vitro drug metabolism screening studies involving the CYP 2D6 and the CYP 3A4 isozymes. J Pharm Biomed Anal. 2005 Apr 1;37(4):739-49. Epub 2004 Dec 30. - Pubmed
DTHybrid score 0.5738
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • -
  • Wojcikowski J, Boksa J, Daniel WA: Main contribution of the cytochrome P450 isoenzyme 1A2 (CYP1A2) to N-demethylation and 5-sulfoxidation of the phenothiazine neuroleptic chlorpromazine in human liver--A comparison with other phenothiazines. Biochem Pharmacol. 2010 Oct 15;80(8):1252-9. Epub 2010 Jul 6. - Pubmed
DTHybrid score 0.4593
Cytochrome P450 2C19
Name Cytochrome P450 2C19
Gene Name CYP2C19
Actions substrate
References
  • -
  • Wojcikowski J, Boksa J, Daniel WA: Main contribution of the cytochrome P450 isoenzyme 1A2 (CYP1A2) to N-demethylation and 5-sulfoxidation of the phenothiazine neuroleptic chlorpromazine in human liver--A comparison with other phenothiazines. Biochem Pharmacol. 2010 Oct 15;80(8):1252-9. Epub 2010 Jul 6. - Pubmed
DTHybrid score 0.3655

Transporters


Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions Not Available
References
  • Bednarczyk D, Ekins S, Wikel JH, Wright SH: Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1. Mol Pharmacol. 2003 Mar;63(3):489-98. - Pubmed
DTHybrid score 0.2708

Carriers


Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions
References Not Available
DTHybrid score 0.2708

Predictions


Id Partner name Gene Name Score
4757 Cytochrome P450 2C9 CYP2C9 0.3015
1588 Multidrug resistance protein 1 ABCB1 0.2693
4118 Cytochrome P450 3A5 CYP3A5 0.2008
556 Alpha-1A adrenergic receptor ADRA1A 0.1993
4924 Cytochrome P450 2C8 CYP2C8 0.1781
590 5-hydroxytryptamine 2C receptor HTR2C 0.1758
318 Alpha-2A adrenergic receptor ADRA2A 0.1723
638 D(3) dopamine receptor DRD3 0.1569
6013 Cytochrome P450 2E1 CYP2E1 0.1497
6107 Cytochrome P450 3A7 CYP3A7 0.1487
6030 Cytochrome P450 2B6 CYP2B6 0.1475
432 D(4) dopamine receptor DRD4 0.1443
632 Alpha-1B adrenergic receptor ADRA1B 0.1392
492 Histamine H1 receptor HRH1 0.1374
629 Alpha-2B adrenergic receptor ADRA2B 0.1241
163 D(1B) dopamine receptor DRD5 0.1232
378 Alpha-2C adrenergic receptor ADRA2C 0.123
885 5-hydroxytryptamine 1B receptor HTR1B 0.1207
103 Muscarinic acetylcholine receptor M1 CHRM1 0.1123
725 5-hydroxytryptamine 1D receptor HTR1D 0.1101
6024 Cytochrome P450 1A1 CYP1A1 0.1067
436 5-hydroxytryptamine 2B receptor HTR2B 0.1039
824 Sodium-dependent serotonin transporter SLC6A4 0.1022
6144 Solute carrier family 22 member 2 SLC22A2 0.1016
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0998
716 5-hydroxytryptamine 7 receptor HTR7 0.0882
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0815
5718 Cytochrome P450 2A6 CYP2A6 0.0774
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0756
20 Prostaglandin G/H synthase 1 PTGS1 0.0746
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0707
193 Beta-1 adrenergic receptor ADRB1 0.0703
766 Beta-2 adrenergic receptor ADRB2 0.07
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0699
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0646
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0628
1729 Solute carrier family 22 member 6 SLC22A6 0.0624
789 Alpha-1D adrenergic receptor ADRA1D 0.062
118 Organic cation/carnitine transporter 2 SLC22A5 0.0569
3941 Amine oxidase [flavin-containing] A MAOA 0.056
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0555
6106 Cytochrome P450 2C18 CYP2C18 0.055
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0537
341 5-hydroxytryptamine 3 receptor HTR3A 0.052
1256 5-hydroxytryptamine 6 receptor HTR6 0.052
713 Sodium-dependent dopamine transporter SLC6A3 0.0495
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0493
6147 Solute carrier family 22 member 3 SLC22A3 0.0466
6142 Solute carrier family 22 member 8 SLC22A8 0.0431
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0422
94 5-hydroxytryptamine 4 receptor HTR4 0.0419
290 Prostaglandin G/H synthase 2 PTGS2 0.0411
862 Multidrug resistance-associated protein 1 ABCC1 0.0399
3923 Cholinesterase BCHE 0.0398
833 Organic cation/carnitine transporter 1 SLC22A4 0.0397
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0392
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0389
465 Calmodulin CALM1 0.037
3811 Cytochrome P450 19A1 CYP19A1 0.0342
1898 Cytochrome P450 1B1 CYP1B1 0.0334
36 Insulin receptor INSR 0.0325
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.032
776 Bile salt export pump ABCB11 0.03
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0298
3939 Amine oxidase [flavin-containing] B MAOB 0.0293
847 Mu-type opioid receptor OPRM1 0.029
6143 Solute carrier family 22 member 7 SLC22A7 0.0284
731 HIV-1 protease HIV-1 protease 0.0284
474 Acetylcholinesterase ACHE 0.0284
528 5-hydroxytryptamine 1E receptor HTR1E 0.0283
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0283
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.028
511 5-hydroxytryptamine 1F receptor HTR1F 0.027
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0261
891 Dihydropteroate synthase folP 0.0261
5359 Dihydropteroate synthase folP 0.0261
7175 Dihydropteroate synthase sulI 0.0261
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0259
124 Histamine H2 receptor HRH2 0.0258
136 Estrogen receptor ESR1 0.0247
696 Kappa-type opioid receptor OPRK1 0.0245
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0243
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0242
2164 Multidrug resistance-associated protein 4 ABCC4 0.0236
467 Delta-type opioid receptor OPRD1 0.0233
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0231
871 Glucocorticoid receptor NR3C1 0.023
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0229
174 Sigma 1-type opioid receptor SIGMAR1 0.0225
131 Synaptic vesicular amine transporter SLC18A2 0.0224
1024 Solute carrier family 22 member 11 SLC22A11 0.0222
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0219
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0203
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0201
817 DNA topoisomerase 2-alpha TOP2A 0.0193
260 Cytochrome P450 51 ERG11 0.0192
761 Cytochrome P450 51 ERG11 0.0192
3163 Cytochrome P450 51 cyp51 0.0192
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0191
1517 Beta-3 adrenergic receptor ADRB3 0.0182
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.018
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0176
1389 Transforming growth factor beta-1 TGFB1 0.0169
756 Sex hormone-binding globulin SHBG 0.0164
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0163
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0163
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0163
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0163
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0159
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0157
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0155
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0153
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0153
923 Glutamate receptor 3 GRIA3 0.0149
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0149
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0148
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0147
477 DNA topoisomerase 4 subunit A parC 0.0146
886 DNA topoisomerase 4 subunit A parC 0.0146
6226 DNA topoisomerase 4 subunit A parC 0.0146
380 Cytochrome P450 17A1 CYP17A1 0.0145
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0144
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0144
404 DNA gyrase subunit A gyrA 0.0144
6224 DNA gyrase subunit A gyrA 0.0144
6541 Peptostreptococcal albumin-binding protein pab 0.0142
921 Glutamate receptor 2 GRIA2 0.0142
146 Androgen receptor AR 0.014
6031 Cytochrome P450 3A43 CYP3A43 0.0139
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0138
3426 Glutamine synthetase glnA 0.0136
3987 Glutamine synthetase GLUL 0.0136
468 Cytochrome P450 4A11 CYP4A11 0.0136
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0135
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0135
1656 CYP2B protein CYP2B 0.0134
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0133
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0132
238 Peroxisome proliferator-activated receptor gamma PPARG 0.013
6148 Multidrug resistance-associated protein 7 ABCC10 0.0128
122 P2Y purinoceptor 12 P2RY12 0.0126
6432 Transporter snf 0.0125
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0123
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0123
3947 Xanthine dehydrogenase/oxidase XDH 0.012
844 Epidermal growth factor receptor EGFR 0.0118
6141 Sodium/bile acid cotransporter SLC10A1 0.0117
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0115
614 Progesterone receptor PGR 0.0114
373 Transthyretin TTR 0.0114
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0114
6014 Cytochrome P450 2A13 CYP2A13 0.0112
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.011
6182 Cytochrome P450 2J2 CYP2J2 0.011
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0108
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0108
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0107
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0106
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0106
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0106
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0104
4604 Liver carboxylesterase 1 CES1 0.0103
70 Type-1 angiotensin II receptor AGTR1 0.0103
6220 Aryl hydrocarbon receptor AHR 0.0102
777 Tumor necrosis factor TNF 0.0102
869 Estrogen receptor beta ESR2 0.0102
818 50S ribosomal protein L10 rplJ 0.0102
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.01
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0099
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0099
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0099
738 Monocarboxylate transporter 1 SLC16A1 0.0099
2211 Fatty acid-binding protein, heart FABP3 0.0098
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0098
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0098
705 Glutamate receptor 1 GRIA1 0.0097
482 Glycine receptor subunit alpha-1 GLRA1 0.0097
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0097
509 Thymidine kinase TK 0.0097
570 Thymidine kinase TK 0.0097
2559 Thymidine kinase TK 0.0097
3430 Thymidine kinase tdk 0.0097
3518 Thymidine kinase TK 0.0097
5301 Thymidine kinase tdk 0.0097
5771 Thymidine kinase ORF36 0.0097
7009 Thymidine kinase ORF36 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0096
571 Melatonin receptor type 1A MTNR1A 0.0096
362 Melatonin receptor type 1B MTNR1B 0.0096
566 Serotransferrin TF 0.0094
183 Vascular endothelial growth factor A VEGFA 0.0094
232 Corticosteroid-binding globulin SERPINA6 0.0093
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0092
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0092
504 Mast/stem cell growth factor receptor KIT 0.0092
672 Prostaglandin F2-alpha receptor PTGFR 0.009
164 Histamine H4 receptor HRH4 0.0089
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0087
537 ATP synthase delta chain, mitochondrial ATP5D 0.0087
16 Adenosine A1 receptor ADORA1 0.0087
6136 Multidrug resistance-associated protein 5 ABCC5 0.0087
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0086
338 DNA polymerase UL30 0.0086
379 DNA polymerase UL54 0.0086
697 DNA polymerase ORF28 0.0086
2482 DNA polymerase 43 0.0086
4104 DNA polymerase BALF5 0.0086
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0084
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0083
1618 High affinity nerve growth factor receptor NTRK1 0.0083
6102 Arylamine N-acetyltransferase 2 NAT2 0.0083
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0083
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0083
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0083
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0083
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0082
427 Substance-P receptor TACR1 0.0082
1178 Adenosine A2a receptor ADORA2A 0.0082
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0082
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0082
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0081
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0081
565 Extracellular calcium-sensing receptor CASR 0.008
6525 Group IID secretory phospholipase A2 PLA2G2D 0.008
811 Translocator protein TSPO 0.0079
228 Beta platelet-derived growth factor receptor PDGFRB 0.0079
173 Toll-like receptor 7 TLR7 0.0079
161 Tubulin beta chain TUBB 0.0079
312 Tubulin beta chain TUB2 0.0079
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0078
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0078
694 Matrix protein 2 M 0.0078
645 Penicillin-binding protein 1A mrcA 0.0078
5805 Penicillin-binding protein 1A ponA 0.0078
6185 Penicillin-binding protein 1A mrcA 0.0078
6799 Penicillin-binding protein 1A pbpA 0.0078
442 Envelope glycoprotein gp41 0.0078
4859 Envelope glycoprotein env 0.0078
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0078
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0078
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0077
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0077
6137 Multidrug resistance-associated protein 6 ABCC6 0.0077
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0077
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0076
1757 Myeloperoxidase MPO 0.0076
6085 Fatty acid-binding protein, intestinal FABP2 0.0075
904 Glutathione S-transferase P GSTP1 0.0074
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0073
4773 Deoxycytidine kinase DCK 0.0073
6010 Thiamine transporter 1 SLC19A2 0.0073
4148 Serine/threonine-protein kinase mTOR MTOR 0.0073
153 Dopamine beta-hydroxylase DBH 0.0073
543 Penicillin-binding protein 1B mrcB 0.0072
6186 Penicillin-binding protein 1B ponB 0.0072
6822 Penicillin-binding protein 1b pbp1b 0.0072
6844 Penicillin-binding protein 1b pbp1b 0.0072
1 Peptidoglycan synthetase ftsI ftsI 0.0071
4155 Peptidoglycan synthetase ftsI ftsI 0.0071
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0071
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0071
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0071
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0071
26 Vascular endothelial growth factor receptor 3 FLT4 0.0071
6043 Putative G-protein coupled receptor 44 GPR44 0.007
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.007
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0069
407 Vascular endothelial growth factor receptor 2 KDR 0.0069
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0068
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0068
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0068
32 Vascular endothelial growth factor receptor 1 FLT1 0.0068
3560 Gentamicin 3'-acetyltransferase aacC1 0.0067
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0067
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0066
175 Thiamin pyrophosphokinase 1 TPK1 0.0066
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0065
6070 Nischarin NISCH 0.0065
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0065
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0064
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0064
952 Dipeptidyl peptidase 4 DPP4 0.0064
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
1119 Peroxiredoxin-5, mitochondrial PRDX5 0.0063
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0063
592 Carbonic anhydrase 4 CA4 0.0062
4122 Histone deacetylase 2 HDAC2 0.0061
6020 Aldehyde oxidase AOX1 0.006
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.006
1010 Cytochrome P450 51A1 CYP51A1 0.006
633 Penicillin-binding proteins 1A/1B pbpA 0.0059
3810 Catechol O-methyltransferase COMT 0.0059
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0059
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0059
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0059
1830 5'-nucleotidase NT5E 0.0059
558 Solute carrier family 12 member 1 SLC12A1 0.0058
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0058
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0058
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0058
1050 Bile salt sulfotransferase SULT2A1 0.0057
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0057
3932 Glutathione S-transferase A2 GSTA2 0.0057
6151 Monocarboxylate transporter 10 SLC16A10 0.0057
4120 NADPH--cytochrome P450 reductase POR 0.0056
357 Carbonic anhydrase 2 CA2 0.0056
6859 Protein S100-A4 S100A4 0.0055
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0055
6506 Stathmin-4 STMN4 0.0055
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0054
365 Dihydrofolate reductase DHFR 0.0054
2381 Dihydrofolate reductase DFR1 0.0054
2833 Dihydrofolate reductase Not Available 0.0054
2931 Dihydrofolate reductase folA 0.0054
3544 Dihydrofolate reductase folA 0.0054
3682 Dihydrofolate reductase folA 0.0054
6642 Dihydrofolate reductase folA 0.0054
6756 Dihydrofolate reductase dfrA 0.0054
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0053
2853 14 kDa fatty acid-binding protein Not Available 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0053
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0053
49 Endothelin B receptor EDNRB 0.0052
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0052
712 Tubulin alpha chain TUB1 0.0052
284 DNA-directed RNA polymerase beta chain rpoB 0.0052
5773 DNA-directed RNA polymerase beta chain rpoB 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
273 Apoptosis regulator Bcl-2 BCL2 0.0052
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0051
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0051
4203 Histamine N-methyltransferase HNMT 0.0051
2112 Toll-like receptor 9 TLR9 0.0051
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0051
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.005
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.005
613 Atrial natriuretic peptide receptor A NPR1 0.005
6100 BDNF/NT-3 growth factors receptor NTRK2 0.005
295 Carbonic anhydrase 1 CA1 0.005
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.005
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.005
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.005
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.005
6027 Alkaline phosphatase, tissue-nonspecific isozyme ALPL 0.005
6171 Solute carrier family 28 member 3 SLC28A3 0.0049
578 Endothelin-1 receptor EDNRA 0.0049
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0048
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0048
6184 D-alanyl-D-alanine carboxypeptidase dacC dacC 0.0048
68 Cannabinoid receptor 1 CNR1 0.0048
33 Cystine/glutamate transporter SLC7A11 0.0048
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0048
459 Retinoic acid receptor RXR-alpha RXRA 0.0048
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0047
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0047
976 Platelet glycoprotein IX GP9 0.0047
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0047
856 Vitamin D3 receptor VDR 0.0047
737 Mineralocorticoid receptor NR3C2 0.0047
2183 Fatty acid-binding protein, adipocyte FABP4 0.0047
828 Phenylalanine-4-hydroxylase PAH 0.0046
3109 Phenylalanine-4-hydroxylase phhA 0.0046
3382 Glycolipid transfer protein GLTP 0.0046
4228 Keratin, type II cytoskeletal 7 KRT7 0.0046
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0046
814 Ryanodine receptor 1 RYR1 0.0046
4237 50S ribosomal protein L22 rplV 0.0046
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0045
6149 Solute carrier family 22 member 10 SLC22A10 0.0045
303 Diamine acetyltransferase 2 SAT2 0.0045
623 Spermine oxidase SMOX 0.0045
1317 Spermine synthase SMS 0.0045
768 FK506-binding protein 1A FKBP1A 0.0045
6146 High affinity copper uptake protein 1 SLC31A1 0.0045
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0044
115 Penicillin-binding protein 2 mrdA 0.0044
6069 Penicillin-binding protein 2 mrdA 0.0044
6118 Penicillin-binding protein 2 penA 0.0044
6187 Penicillin-binding protein 2 pbpA 0.0044
6686 Penicillin-binding protein 2 pbp2 0.0044
6939 Penicillin-binding protein 2 mrdA 0.0044
7163 Penicillin-binding protein 2 pbpA 0.0044
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0044
1864 RET proto-oncogene RET 0.0044
2178 Metabotropic glutamate receptor 5 GRM5 0.0044
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0044
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0044
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0044
5645 DNA topoisomerase 4 subunit B parE 0.0044
6227 DNA topoisomerase 4 subunit B parE 0.0044
887 DNA gyrase subunit B gyrB 0.0044
4150 DNA gyrase subunit B gyrB 0.0044
6225 DNA gyrase subunit B gyrB 0.0044
1360 Sphingomyelin phosphodiesterase SMPD1 0.0043
6044 Serum paraoxonase/lactonase 3 PON3 0.0043
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0043
518 Peroxidase/catalase T katG 0.0043
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.0043
2539 Tubulin alpha-1 chain TUBA4A 0.0043
4311 tRNA TRDMT1 0.0042
4325 tRNA trmD 0.0042
4328 tRNA trmD 0.0042
1629 Transcription factor AP-1 JUN 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0042
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0042
1341 Histamine H3 receptor HRH3 0.0042
65 Matrix metalloproteinase-9 Not Available 0.0041
125 DNA polymerase beta POLB 0.0041
275 Arachidonate 5-lipoxygenase ALOX5 0.0041
2300 Lysozyme E 0.0041
3633 Lysozyme R 0.0041
5597 Lysozyme 17 0.0041
2449 Tubulin alpha-3 chain TUBA1A 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
123 Diamine acetyltransferase 1 SAT1 0.004
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.004
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.004
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.004
29 Tubulin beta-1 chain TUBB1 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
6508 Putative uncharacterized protein srtB 0.004
6543 Putative uncharacterized protein tcp14 0.004
6615 Putative uncharacterized protein MT0785 0.004
6623 Putative uncharacterized protein Not Available 0.004
6806 Putative uncharacterized protein AGR_C_2535 0.004
6813 Putative uncharacterized protein SAV4671 0.004
6815 Putative uncharacterized protein AFE_1514 0.004
6819 Putative uncharacterized protein RUMGNA_03254 0.004
6825 Putative uncharacterized protein CV_3270 0.004
4161 Furin FURIN 0.004
1992 Vitamin D-binding protein GC 0.004
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0039
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
5787 Angiopoietin-1 receptor TEK 0.0039
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0039
563 Thyroid peroxidase TPO 0.0038
6067 Penicillin binding protein 2a mecA 0.0038
780 Retinoic acid receptor RXR-gamma RXRG 0.0038
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0038
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
2472 Voltage-gated potassium channel kcsA 0.0038
6366 Voltage-gated potassium channel kcsA 0.0038
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0038
85 Growth hormone receptor GHR 0.0038
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0037
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0037
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0037
6167 Organic solute transporter subunit beta OSTB 0.0036
6166 Organic solute transporter subunit alpha OSTA 0.0036
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0036
634 Squalene monooxygenase SQLE 0.0036
7196 Squalene monooxygenase ERG1 0.0036
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0036
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0036
594 Thyroxine-binding globulin SERPINA7 0.0036
819 Penicillin-binding protein 4 dacB 0.0036
5934 Cytochrome P450 26A1 CYP26A1 0.0036
3611 Cytidine deaminase cdd 0.0036
3707 Cytidine deaminase cdd 0.0036
4211 Cytidine deaminase CDA 0.0036
88 Retinoic acid receptor RXR-beta RXRB 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
117 Sterol O-acyltransferase 1 SOAT1 0.0035
939 50S ribosomal protein L3 rplC 0.0035
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0035
823 Fibroblast growth factor receptor 2 FGFR2 0.0034
322 Vasopressin V2 receptor AVPR2 0.0034
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0034
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0034
2499 Tubulin beta-2C chain TUBB2C 0.0034
6126 Carbonic anhydrase 7 CA7 0.0034
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0034
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0034
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0034
758 Thyroid hormone receptor alpha THRA 0.0033
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0033
233 Potassium channel subfamily K member 2 KCNK2 0.0033
1483 Membrane copper amine oxidase AOC3 0.0033
2251 Thymidylate kinase tmk 0.0033
2254 Thymidylate kinase DTYMK 0.0033
3522 Thymidylate kinase tmk 0.0033
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0032
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0032
707 72 kDa type IV collagenase MMP2 0.0032
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0032
6677 Myelin P2 protein PMP2 0.0032
1867 Major prion protein PRNP 0.0032
1714 Mitogen-activated protein kinase 3 MAPK3 0.0032
581 Cytochrome P450 2R1 CYP2R1 0.0032
595 Fibrinogen alpha chain FGA 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
2257 Uridine phosphorylase udp 0.0031
5132 Uridine phosphorylase udp 0.0031
449 Ornithine decarboxylase ODC1 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.0031
3760 Penicillin-binding protein 5 precursor dacA 0.0031
5300 Antigen peptide transporter 1 TAP1 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
6218 Pannexin-1 PANX1 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.003
1502 Peroxisome proliferator-activated receptor delta PPARD 0.003
5626 Nucleoside diphosphate kinase B NME2 0.003
346 Thyroid hormone receptor beta-1 THRB 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
239 Coagulation factor X F10 0.0029
6103 Arylamine N-acetyltransferase 1 NAT1 0.0029
3813 Fibrinogen gamma chain FGG 0.0029
3812 Fibrinogen beta chain [Contains: Fibrinopeptide B] FGB 0.0029
5126 Arginase rocF 0.0029
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0029
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0029
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0029
244 Angiotensin-converting enzyme ACE 0.0029
3957 Adenosine deaminase ADA 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
992 Protein tyrosine kinase 2 beta PTK2B 0.0028
1192 Sulfotransferase 1A1 SULT1A1 0.0028
6207 30S ribosomal protein S14 rpsN 0.0028
6209 30S ribosomal protein S19 rpsS 0.0028
6712 30S ribosomal protein S19 rpsS 0.0028
6726 30S ribosomal protein S19 rpsS 0.0028
3937 Fatty-acid amide hydrolase FAAH 0.0028
1525 Heparin-binding growth factor 2 FGF2 0.0028
1278 Pro-epidermal growth factor EGF 0.0028
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0027
723 Cytosolic phospholipase A2 PLA2G4A 0.0027
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0027
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0027
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0027
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0027
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0027
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0027
3856 Fibroblast growth factor receptor 3 FGFR3 0.0027
908 Glutathione S-transferase theta-1 GSTT1 0.0027
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0027
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0027
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
6111 DNA polymerase epsilon subunit 4 POLE4 0.0027
889 3-oxoacyl-[acyl-carrier-protein] synthase 1 fabB 0.0027
6860 3-oxoacyl-[acyl-carrier-protein] synthase 1 kasA 0.0027
740 Argininosuccinate synthase ASS1 0.0027
865 Argininosuccinate synthase ASS1 0.0027
2680 Argininosuccinate synthase argG 0.0027
3194 Argininosuccinate synthase argG 0.0027
6112 DNA polymerase epsilon subunit 3 POLE3 0.0027
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0026
4210 Toll-like receptor 4 TLR4 0.0026
6110 DNA polymerase epsilon subunit 2 POLE2 0.0026
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0026
165 FL cytokine receptor FLT3 0.0026
4103 Proteasome subunit beta type 2 PSMB2 0.0026
4102 Proteasome subunit beta type 5 PSMB5 0.0026
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0026
4101 Proteasome subunit beta type 1 PSMB1 0.0026
229 Retinoic acid receptor beta RARB 0.0026
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
1648 Elastin ELN 0.0026
162 Retinoic acid receptor gamma-1 RARG 0.0026
730 Retinoic acid receptor alpha RARA 0.0026
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0025
751 Potassium channel subfamily K member 6 KCNK6 0.0025
4252 Penicillin-binding protein 5 dacA 0.0025
5880 Thrombopoietin receptor MPL 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
896 Glutathione S-transferase Mu 1 GSTM1 0.0025
5294 Nucleoside diphosphate kinase A NME1 0.0024
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0024
159 Penicillin-binding protein 2B penA 0.0024
6121 Penicillin-binding protein 2B penA 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
4217 Telomerase reverse transcriptase TERT 0.0024
6231 Pepsin A PGA3 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
3086 Plasmepsin-2 Not Available 0.0023
624 Guanidinoacetate N-methyltransferase GAMT 0.0023
332 Beta-lactamase blaZ 0.0023
2478 Beta-lactamase ampC 0.0023
2613 Beta-lactamase ampC 0.0023
2635 Beta-lactamase ampC 0.0023
2700 Beta-lactamase penP 0.0023
5445 Beta-lactamase blaB 0.0023
6019 Beta-lactamase SHV-7 0.0023
6701 Beta-lactamase cphA 0.0023
172 Potassium channel subfamily K member 1 KCNK1 0.0023
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.0023
1291 cAMP response element-binding protein CREB1 0.0023
1353 DNA topoisomerase 1 TOP1 0.0023
3552 DNA topoisomerase 1 topA 0.0023
208 DNA-directed RNA polymerase beta' chain rpoC 0.0022
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0022
24 Thymidylate synthase TMP1 0.0022
359 Thymidylate synthase TYMS 0.0022
2626 Thymidylate synthase thyA 0.0022
2729 Thymidylate synthase thyA 0.0022
5352 Thymidylate synthase THYA 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
2981 Phospholipase A2, membrane associated PLA2G2A 0.0022
3404 Exotoxin A eta 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
199 Monocarboxylate transporter 8 SLC16A2 0.0022
298 Renin REN 0.0021
3917 Methylenetetrahydrofolate reductase MTHFR 0.0021
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
2091 Endoplasmin HSP90B1 0.0021
6165 Copper-transporting ATPase 1 ATP7A 0.0021
6163 Copper-transporting ATPase 2 ATP7B 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
2207 Rhodopsin RHO 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
331 Retinol-binding protein I, cellular RBP1 0.0021
7 Nitric oxide synthase, inducible NOS2 0.0021
3090 Chitosanase csn 0.002
4149 Nuclear factor NF-kappa-B p100 subunit NFKB2 0.002
6501 Fatty acid-binding protein, liver FABP1 0.002
342 P protein [Includes: DNA-directed DNA polymerase P 0.002
612 P protein [Includes: DNA-directed DNA polymerase P 0.002
319 Opioid receptor, sigma 1 OPRS1 0.002
603 DNA polymerase alpha catalytic subunit POLA1 0.002
1820 Beta-nerve growth factor NGF 0.002
4152 Superoxide dismutase [Cu-Zn] SOD1 0.002
822 Aldose reductase AKR1B1 0.002
106 Cannabinoid receptor 2 CNR2 0.002
489 Monocarboxylate transporter 2 SLC16A7 0.0019
6174 50S ribosomal protein L32 rpmF 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0019
4226 Uridine phosphorylase 2 UPP2 0.0019
1196 Complement decay-accelerating factor CD55 0.0019
473 L-lactate dehydrogenase A chain LDHA 0.0019
1630 Integrin beta-2 ITGB2 0.0019
2320 Thymidine kinase, cytosolic TK1 0.0019
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0019
6033 High affinity interleukin-8 receptor A CXCR1 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0018
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0018
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0018
1253 Interferon gamma IFNG 0.0018
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0018
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0018
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0018
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
327 Glutathione reductase gor 0.0018
5110 Glutathione reductase GR2 0.0018
251 Alcohol dehydrogenase 1A ADH1A 0.0018
1374 Natriuretic peptides B NPPB 0.0018
4225 Uridine phosphorylase 1 UPP1 0.0018
1827 Gap junction alpha-1 protein GJA1 0.0018
3312 Fatty acid-binding protein, brain FABP7 0.0018
1908 Vascular cell adhesion protein 1 VCAM1 0.0018
683 Potassium transporter GK0582 0.0018
1198 Serum paraoxonase/arylesterase 1 PON1 0.0018
6223 Penicillin-binding protein 1C pbpC 0.0018
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
3830 Calreticulin CALR 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0017
702 UMP-CMP kinase CMPK1 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0017
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0017
820 Glycine receptor subunit alpha-2 GLRA2 0.0017
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0017
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0017
5682 Ribonuclease pancreatic RNASE1 0.0017
936 Ephrin type-A receptor 2 EPHA2 0.0017
4192 DNA topoisomerase 2-beta TOP2B 0.0017
2021 Thrombomodulin THBD 0.0017
413 Amidophosphoribosyltransferase PPAT 0.0017
2515 Amidophosphoribosyltransferase purF 0.0017
3714 Amidophosphoribosyltransferase purF 0.0017
1074 Urokinase-type plasminogen activator PLAU 0.0017
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0016
2808 Chloramphenicol acetyltransferase 3 cat3 0.0016
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0016
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0016
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0016
1686 Choline transporter-like protein 1 SLC44A1 0.0016
3926 Choline transporter-like protein 2 SLC44A2 0.0016
861 Choline kinase alpha CHKA 0.0016
3927 Choline transporter-like protein 3 SLC44A3 0.0016
769 High-affinity choline transporter 1 SLC5A7 0.0016
700 Choline dehydrogenase, mitochondrial CHDH 0.0016
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0016
3925 Choline transporter-like protein 4 SLC44A4 0.0016
576 Choline O-acetyltransferase CHAT 0.0016
3922 Phospholipase D2 PLD2 0.0016
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0016
3924 Phospholipase D1 PLD1 0.0016
6034 Hydroxyindole O-methyltransferase ASMT 0.0016
6035 Nuclear receptor ROR-beta RORB 0.0016
6036 Eosinophil peroxidase EPX 0.0016
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0016
144 Hemoglobin subunit alpha HBA1 0.0016
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0016
1243 Cathepsin D CTSD 0.0016
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0016
3616 Fatty acid-binding protein, epidermal FABP5 0.0016
5431 Lipid binding protein Not Available 0.0016
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0016
5433 UPF0230 protein TM_1468 TM_1468 0.0016
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0016
444 Alcohol dehydrogenase 1B ADH1B 0.0016
1852 Microtubule-associated protein 2 MAP2 0.0016
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0016
1268 Neuropeptide S receptor NPSR1 0.0016
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0016
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0016
3233 Bile acid receptor NR1H4 0.0015
277 Purine nucleoside phosphorylase PNP 0.0015
2870 Purine nucleoside phosphorylase punA 0.0015
2945 Purine nucleoside phosphorylase punA 0.0015
4659 Purine nucleoside phosphorylase TM_1596 0.0015
4825 Purine nucleoside phosphorylase TTHA1435 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
6138 Multidrug resistance protein 3 ABCB4 0.0015
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0015
3601 Dihydropteroate synthase 1 folP1 0.0015
3807 Dihydropteroate synthase 1 folP1 0.0015
3808 Dihydropteroate synthase 2 folP2 0.0015
2417 Chloramphenicol acetyltransferase cat 0.0015
3278 Chloramphenicol acetyltransferase cat 0.0015
268 Adenosine A2b receptor ADORA2B 0.0015
2810 Dr hemagglutinin structural subunit draA 0.0015
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
469 Annexin A1 ANXA1 0.0015
6824 Tyrosine-protein kinase Lyn LYN 0.0014
1541 Metalloproteinase mmp20 0.0014
572 Integrin alpha-L ITGAL 0.0014
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0014
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0014
765 Indoleamine 2,3-dioxygenase IDO1 0.0014
6073 Potassium channel subfamily K member 9 KCNK9 0.0014
6072 Potassium channel subfamily K member 3 KCNK3 0.0014
3913 Glutamic acid decarboxylase GAD65 0.0014
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0014
1262 Corticotropin-lipotropin POMC 0.0014
84 Nuclear receptor 0B1 NR0B1 0.0014
517 Alcohol dehydrogenase 1C ADH1C 0.0014
291 Nitric-oxide synthase, endothelial NOS3 0.0014
3639 Thymidine phosphorylase deoA 0.0014
3936 Thymidine phosphorylase TYMP 0.0014
54 Prothrombin F2 0.0013
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0013
283 SEC14-like protein 2 SEC14L2 0.0013
1039 Histone deacetylase 9 HDAC9 0.0013
2236 Casein kinase II subunit alpha CSNK2A1 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0013
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0013
6131 Carbonic anhydrase 14 CA14 0.0013
6459 Glycodelin PAEP 0.0013
1275 Estrogen sulfotransferase SULT1E1 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
1405 Thiopurine S-methyltransferase TPMT 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0012
760 Fibroblast growth factor 1 FGF1 0.0012
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0012
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
6042 Prostaglandin reductase 2 PTGR2 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
3587 Gastrotropin FABP6 0.0012
6122 Carbonic anhydrase 3 CA3 0.0012
1295 Fatty acid synthase FASN 0.0012
735 Alanine aminotransferase 1 GPT 0.0012
3904 Alanine aminotransferase 2 GPT2 0.0012
1792 Tissue-type plasminogen activator PLAT 0.0011
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0011
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0011
1063 Signal transducer and activator of transcription 5B STAT5B 0.0011
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0011
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
3809 Estrogen-related receptor gamma ESRRG 0.0011
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4116 Dihydropteroate synthetase Not Available 0.001
2461 D-alanyl-D-alanine carboxypeptidase Not Available 0.001
5756 D-alanyl-D-alanine carboxypeptidase dac 0.001
1144 Hepatocyte growth factor receptor MET 0.001
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
2216 Fibroblast growth factor receptor 4 FGFR4 0.001
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.001
6228 Nuclear receptor coactivator 1 NCOA1 0.001
1313 Lactoylglutathione lyase GLO1 0.001
2268 Cholesterol oxidase choB 0.0009
2822 Cholesterol oxidase choA 0.0009
5798 Mitogen-activated protein kinase 11 MAPK11 0.0009
267 Plasminogen activator inhibitor 1 SERPINE1 0.0009
484 Tyrosine-protein kinase ABL2 ABL2 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
6048 Troponin C, skeletal muscle TNNC2 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
2132 Protein S100-B S100B 0.0009
6221 Steroid hormone receptor ERR1 ESRRA 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
2298 Cytochrome P450-cam camC 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
1025 Aquaporin-1 AQP1 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
461 Glycine receptor subunit alpha-3 GLRA3 0.0007
130 Prostacyclin synthase PTGIS 0.0007
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0007
5818 Folate receptor alpha FOLR1 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6134 Sodium channel subunit beta-3 SCN3B 0.0007
6133 Sodium channel subunit beta-2 SCN2B 0.0007
6135 Sodium channel subunit beta-4 SCN4B 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
6132 Sodium channel subunit beta-1 SCN1B 0.0007
6129 Carbonic anhydrase-related protein 11 CA11 0.0007
6127 Carbonic anhydrase-related protein CA8 0.0007
6128 Carbonic anhydrase-related protein 10 CA10 0.0007
5924 Microtubule-associated protein 4 MAP4 0.0007
5923 Microtubule-associated protein tau MAPT 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
1245 Vitamin K-dependent protein S PROS1 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
293 Gamma-glutamyl hydrolase GGH 0.0006
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0006
6130 Carbonic anhydrase 13 CA13 0.0006
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0006
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0006
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0006
6168 Solute carrier family 22 member 16 SLC22A16 0.0006
1650 Heme carrier protein 1 SLC46A1 0.0006
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0006
1569 G1/S-specific cyclin-D1 CCND1 0.0006
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
76 Nitric-oxide synthase, brain NOS1 0.0005
6743 Non-fluorescent flavoprotein luxF 0.0005
6753 Apolipoprotein M APOM 0.0005
2528 Fatty acid metabolism regulator protein fadR 0.0005
6740 Fatty acid metabolism regulator protein fadR 0.0005
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0005
394 Calcineurin subunit B isoform 1 PPP3R1 0.0005
6742 Recoverin RCVRN 0.0005
6747 Chalcone/stilbene synthase family protein MT1417 0.0005
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0005
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0005
6751 Gag polyprotein gag 0.0005
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0005
6749 Polyprotein Not Available 0.0005
798 Osteocalcin BGLAP 0.0005
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0005
3007 Carbonic anhydrase 12 CA12 0.0005
4205 Carbonic anhydrase 9 CA9 0.0005
5961 Insulin INS 0.0005
369 Coagulation factor VII F7 0.0005
6527 Lymphocyte antigen 96 LY96 0.0005
6755 Poliovirus receptor PVR 0.0005
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0004
6750 ADP-ribosylation factor 6 ARF6 0.0004
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0004
6524 Protein tonB tonB 0.0004
4943 Cytochrome c6 petJ 0.0004
4954 Soluble cytochrome b558 Not Available 0.0004
4942 Diheme cytochrome c napB napB 0.0004
4916 Cyanoglobin glbN 0.0004
4994 Hemoglobin-like protein HbO glbO 0.0004
5000 HemO hemO 0.0004
4981 Iron-starvation protein PigA pigA 0.0004
4984 Neuroglobin NGB 0.0004
4947 Bacterial hemoglobin vhb 0.0004
4935 Cytochrome c-554 cycA1 0.0004
4975 Cytochrome c-556 RPA3973 0.0004
4936 Cytochrome c2 iso-2 Not Available 0.0004
4934 Cytochrome c-551 nirM 0.0004
5218 Cytochrome c-551 nirM 0.0004
4905 Cytochrome c2 Not Available 0.0004
4939 Cytochrome c2 cycA 0.0004
4964 Cytochrome c2 cycA 0.0004
4979 Cytochrome c2 cycA 0.0004
6673 Cytochrome c2 cycA 0.0004
4910 Cytoglobin CYGB 0.0004
3116 Bacterioferritin bfr 0.0004
4906 Bacterioferritin bfr 0.0004
4965 Bacterioferritin bfr 0.0004
4915 Cytochrome c-550 psbV 0.0004
4959 Cytochrome c-550 psbV 0.0004
5216 Cytochrome c-550 psbV 0.0004
4925 Cytochrome c-type protein SHP shp 0.0004
4961 Hemophore HasA hasA 0.0004
4909 CooA protein cooA 0.0004
4998 Hemoglobin-like protein yjbI yjbI 0.0004
4904 Cytochrome c family protein GSU1996 0.0004
4931 Cytochrome P450 167A1 CYP167A1 0.0004
644 Heme oxygenase 2 HMOX2 0.0004
4982 Heme oxygenase 2 pbsA2 0.0004
4937 Cytochrome oxidase subunit II rcoxA 0.0004
4903 Methyl-accepting chemotaxis protein Tar4 0.0004
4971 Nonaheme cytochrome c hmcA 0.0004
4989 Cytochrome c551 peroxidase ccp 0.0004
5222 Cytochrome c551 peroxidase ccpA 0.0004
4976 Apocytochrome f petA 0.0004
6407 Apocytochrome f petA 0.0004
4907 Cytochrome c-L moxG 0.0004
6865 Cytochrome c-L moxG 0.0004
4972 P450cin cinA 0.0004
4960 Putative cytochrome P450-family protein SCO7417 0.0004
4764 Cytochrome P450 165C4 CYP165C4 0.0004
4926 Heme-based aerotactic transducer hemAT hemAT 0.0004
4999 Cytochrome P450 165B3 CYP165B3 0.0004
4952 Catalase/peroxidase katA 0.0004
4993 Hydroxylamine oxidoreductase hao1 0.0004
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0004
4922 Cytochrome c, putative SO_4144 0.0004
2616 Ganglioside GM2 activator GM2A 0.0004
3093 Catalase HPII katE 0.0004
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0004
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0004
1176 Mitogen-activated protein kinase 1 MAPK1 0.0004
2297 Genome polyprotein Not Available 0.0004
2322 Genome polyprotein Not Available 0.0004
2694 Genome polyprotein Not Available 0.0004
2719 Genome polyprotein Not Available 0.0004
2860 Genome polyprotein Not Available 0.0004
2928 Genome polyprotein Not Available 0.0004
3160 Genome polyprotein Not Available 0.0004
3260 Genome polyprotein Not Available 0.0004
4783 Genome polyprotein Not Available 0.0004
5726 Genome polyprotein Not Available 0.0004
5779 Genome polyprotein Not Available 0.0004
5867 Genome polyprotein Not Available 0.0004
6253 Genome polyprotein Not Available 0.0004
6301 Genome polyprotein Not Available 0.0004
6380 Genome polyprotein Not Available 0.0004
6381 Genome polyprotein Not Available 0.0004
6437 Genome polyprotein Not Available 0.0004
6520 Genome polyprotein Not Available 0.0004
6521 Genome polyprotein Not Available 0.0004
6652 Genome polyprotein Not Available 0.0004
6734 Genome polyprotein Not Available 0.0004
6735 Genome polyprotein Not Available 0.0004
6736 Genome polyprotein Not Available 0.0004
6737 Genome polyprotein Not Available 0.0004
6738 Genome polyprotein Not Available 0.0004
6739 Genome polyprotein Not Available 0.0004
6744 Genome polyprotein Not Available 0.0004
6748 Genome polyprotein Not Available 0.0004
6894 Genome polyprotein Not Available 0.0004
6898 Genome polyprotein Not Available 0.0004
6316 ADP-ribosylation factor 1 ARF1 0.0004
719 Retinoic acid receptor responder protein 1 RARRES1 0.0003
770 Retinoic acid-induced protein 3 GPRC5A 0.0003
864 Gag-Pol polyprotein gag-pol 0.0003
2237 Gag-Pol polyprotein gag-pol 0.0003
2326 Gag-Pol polyprotein gag-pol 0.0003
2451 Gag-Pol polyprotein gag-pol 0.0003
2901 Gag-Pol polyprotein gag-pol 0.0003
3165 Gag-Pol polyprotein gag-pol 0.0003
3722 Gag-Pol polyprotein gag-pol 0.0003
6306 Gag-Pol polyprotein gag-pol 0.0003
6624 Gag-Pol polyprotein gag-pol 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
569 Retinal dehydrogenase 2 ALDH1A2 0.0003
4920 Peroxidase/catalase katG 0.0003
4948 Cytochrome c-553 Not Available 0.0003
4923 Cytochrome c3 DvMF_2499 0.0003
4945 Cytochrome c3 Not Available 0.0003
4949 Cytochrome c3 DVU_3171 0.0003
4968 Cytochrome c3 cytc3 0.0003
4997 Cytochrome c3 SO_2727 0.0003
5219 Cytochrome c3 cyd 0.0003
2119 Cytochrome b5 CYB5A 0.0003
4902 Nine-heme cytochrome c Ddes_2038 0.0003
3189 High-molecular-weight cytochrome c hmcA 0.0003
4990 PpcA ppcA 0.0003
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0003
2427 Ferrichrome-iron receptor fhuA 0.0003
3375 Acidic cytochrome c3 Not Available 0.0003
4988 Sulfite oxidase, mitochondrial SUOX 0.0003
4037 Hypothetical protein GPX1 0.0003
4297 Hypothetical protein SP_1951 0.0003
4521 Hypothetical protein BC_2969 0.0003
4540 Hypothetical protein TM_1070 0.0003
4555 Hypothetical protein MT1739 0.0003
4569 Hypothetical protein mshD 0.0003
4578 Hypothetical protein PA3270 0.0003
4747 Hypothetical protein PA3967 0.0003
5177 Hypothetical protein TM_0096 0.0003
5194 Hypothetical protein PA1204 0.0003
5240 Hypothetical protein Rv2991 0.0003
5370 Hypothetical protein TM_1158 0.0003
5710 Hypothetical protein Tb927.5.1360 0.0003
3570 Cytochrome P450 152A1 cypC 0.0003
2915 Sensor protein fixL fixL 0.0003
4944 Sensor protein fixL fixL 0.0003
4289 Cytochrome P450 TT_P0059 0.0003
6262 Cytochrome P450 staP 0.0003
4813 Heme oxygenase hmuO 0.0003
5769 Heme oxygenase Not Available 0.0003
4992 Cytochrome c peroxidase Not Available 0.0003
4385 Cytochrome c' Not Available 0.0003
4967 Cytochrome c' cycA 0.0003
5038 Cytochrome c' Not Available 0.0003
5223 Cytochrome c' cycP 0.0003
611 Retinal dehydrogenase 1 ALDH1A1 0.0003
2230 Catalase CAT 0.0003
3249 Catalase katA 0.0003
3625 Catalase katA 0.0003
4539 Catalase katA 0.0003
4941 Catalase katB 0.0003
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0003
3670 Soluble cytochrome b562 precursor cybC 0.0003
3411 Cytochrome P450 121 cyp121 0.0003
3291 Cytochrome c-552 cycA 0.0003
4927 Cytochrome c-552 nrfA 0.0003
4938 Cytochrome c-552 cycA 0.0003
4953 Cytochrome c-552 nrfA 0.0003
5217 Cytochrome c-552 cycM 0.0003
2617 Nitric oxide synthase oxygenase nos 0.0003
2701 Nitric oxide synthase oxygenase nos 0.0003
3102 Flavohemoprotein hmp 0.0003
4969 Flavohemoprotein hmp 0.0003
4386 Hemoglobin-like protein HbN glbN 0.0003
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0003
3127 Nitrite reductase nirS 0.0002
3284 Nitrite reductase nirS 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
3221 Cytochrome c4 cc4 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
4608 Putative cytochrome P450 SCO1207 0.0002
4963 Putative cytochrome P450 SCO2884 0.0002
6254 Putative cytochrome P450 SCO6998 0.0002
358 Cystathionine beta-synthase CBS 0.0002
1507 Cytochrome c CYCS 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0002
810 Heme oxygenase 1 HMOX1 0.0002
3391 Heme oxygenase 1 pbsA1 0.0002
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