DT-Web

DB00772 - Malathion


Identification
Name Malathion
Accession Number DB00772 (APRD01081)
Type small molecule
Description A wide spectrum aliphatic organophosphate insecticide widely used for both domestic and commercial agricultural purposes. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 330.358
Groups approved
Monoisotopic Weight 330.036066232
Pharmacology
Indication For patients infected with Pediculus humanus capitis (head lice and their ova) of the scalp hair.
Mechanism of action Malathion is a nonsystemic, wide-spectrum organophosphate insecticide. It inhibits acetylcholinesterase activity of most eukaryotes. Malathion is toxic to aquatic organisms, but has a relatively low toxicity for birds and mammals. The major metabolites of malathion are mono- and di-carboxylic acid derivatives, and malaoxon is a minor metabolite. However, it is malaoxon that is the strongest cholinesterase inhibitor. Cholinesterases catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. Because of its essential function, chemicals that interfere with the action of cholinesterase are potent neurotoxins, causing muscle spasms and ultimately death.
Absorption Malathion in an acetone vehicle has been reported to be absorbed through normal human skin only to the extent of 8% of the applied dose. Absorption may be increased when malathion is applied to damaged skin. Malathion is rapidly and effectively absorbed by practically all routes including the gastrointestinal tract, skin, mucous membranes, and lungs. However, it is readily excreted in the urine, and does not accumulate in organs or tissues.
Protein binding Not Available
Biotransformation The major metabolites of malathion are the diacid and monoacid metabolites, namely, malathion dicarboxylic acid (DCA) and malathion monocarboxylic acid (MCA). Malaoxon, the active cholinesterase-inhibiting metabolite of malathion, is a minor metabolite. Both malathion and malaoxon are detoxified by carboxyesterases leading to polar, water-soluble compounds that are excreted.
Route of elimination Not Available
Toxicity Malathion is slightly toxic via the oral route, with reported oral LD50 values of 1000 mg/kg to greater than 10,000 mg/kg in the rat. It is also slightly toxic via the dermal route, with reported dermal LD50 values of greater than 4000 mg/kg in rats. Moderate poisoning can result in chest tightness, difficulty breathing, bradycardia, tachycardia, tremor/ataxia, blurred vision, and confusion. Severe, life-threatening signs include coma, seizures, respiratory arrest, and paralysis. Malathion may also be irritating to the skin and eyes.
Affected organisms
  • Head lice
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Cholinesterase
Name Cholinesterase
Gene Name BCHE
Pharmacological action yes
Actions inhibitor
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Ramos ZR, Fortunato JJ, Agostinho FR, Martins MR, Correa M, Schetinger MR, Dal-Pizzol F, Quevedo J: Influence of malathion on acetylcholinesterase activity in rats submitted to a forced swimming test. Neurotox Res. 2006 Jun;9(4):285-90. - Pubmed
  • Ahmed M, Rocha JB, Mazzanti CM, Morsch AL, Cargnelutti D, Correa M, Loro V, Morsch VM, Schetinger MR: Malathion, carbofuran and paraquat inhibit Bungarus sindanus (krait) venom acetylcholinesterase and human serum butyrylcholinesterase in vitro. Ecotoxicology. 2007 May;16(4):363-9. Epub 2007 Mar 16. - Pubmed
  • da Silva AP, Meotti FC, Santos AR, Farina M: Lactational exposure to malathion inhibits brain acetylcholinesterase in mice. Neurotoxicology. 2006 Dec;27(6):1101-5. Epub 2006 Apr 28. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 0.5677

Enzymes


Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2556
Cytochrome P450 2B6
Name Cytochrome P450 2B6
Gene Name CYP2B6
Actions substrate
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2021

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.1492
4119 Cytochrome P450 2D6 CYP2D6 0.1052
4757 Cytochrome P450 2C9 CYP2C9 0.0963
474 Acetylcholinesterase ACHE 0.0953
6016 Cytochrome P450 2C19 CYP2C19 0.091
1588 Multidrug resistance protein 1 ABCB1 0.0821
4924 Cytochrome P450 2C8 CYP2C8 0.0627
6013 Cytochrome P450 2E1 CYP2E1 0.0594
6024 Cytochrome P450 1A1 CYP1A1 0.054
4118 Cytochrome P450 3A5 CYP3A5 0.05
5718 Cytochrome P450 2A6 CYP2A6 0.0421
6107 Cytochrome P450 3A7 CYP3A7 0.0375
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0373
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0356
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0343
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0287
766 Beta-2 adrenergic receptor ADRB2 0.0282
587 Serum albumin ALB 0.028
20 Prostaglandin G/H synthase 1 PTGS1 0.0277
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0264
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0262
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.026
36 Insulin receptor INSR 0.0258
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0243
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0237
831 D(2) dopamine receptor DRD2 0.0236
6106 Cytochrome P450 2C18 CYP2C18 0.0233
556 Alpha-1A adrenergic receptor ADRA1A 0.0227
3811 Cytochrome P450 19A1 CYP19A1 0.0226
492 Histamine H1 receptor HRH1 0.0226
2433 Capsid protein P40 UL80 0.0213
3569 Capsid protein P40 BVRF2 0.0213
290 Prostaglandin G/H synthase 2 PTGS2 0.0212
318 Alpha-2A adrenergic receptor ADRA2A 0.0199
2049 Gastrin/cholecystokinin type B receptor CCKBR 0.0191
713 Sodium-dependent dopamine transporter SLC6A3 0.019
6145 Solute carrier family 22 member 1 SLC22A1 0.0189
3076 Antigen 85-C fbpC 0.0187
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0185
824 Sodium-dependent serotonin transporter SLC6A4 0.0181
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0177
502 5-hydroxytryptamine 2A receptor HTR2A 0.0171
6144 Solute carrier family 22 member 2 SLC22A2 0.0168
465 Calmodulin CALM1 0.0167
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0164
341 5-hydroxytryptamine 3 receptor HTR3A 0.0156
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.015
2796 Parathion hydrolase opd 0.0147
6539 Parathion hydrolase opd 0.0147
3454 Esterase estA 0.0141
468 Cytochrome P450 4A11 CYP4A11 0.0139
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0136
23 D(1A) dopamine receptor DRD1 0.0136
118 Organic cation/carnitine transporter 2 SLC22A5 0.0132
638 D(3) dopamine receptor DRD3 0.0132
3941 Amine oxidase [flavin-containing] A MAOA 0.0131
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.013
862 Multidrug resistance-associated protein 1 ABCC1 0.0129
1898 Cytochrome P450 1B1 CYP1B1 0.0128
477 DNA topoisomerase 4 subunit A parC 0.0127
886 DNA topoisomerase 4 subunit A parC 0.0127
6226 DNA topoisomerase 4 subunit A parC 0.0127
404 DNA gyrase subunit A gyrA 0.0125
6224 DNA gyrase subunit A gyrA 0.0125
2929 (S)-2-haloacid dehalogenase dhlB 0.0124
2995 (S)-2-haloacid dehalogenase Not Available 0.0124
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0121
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0118
590 5-hydroxytryptamine 2C receptor HTR2C 0.0113
124 Histamine H2 receptor HRH2 0.0113
6147 Solute carrier family 22 member 3 SLC22A3 0.011
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0105
275 Arachidonate 5-lipoxygenase ALOX5 0.0102
958 Insulin-like growth factor 1 receptor IGF1R 0.0102
244 Angiotensin-converting enzyme ACE 0.0101
817 DNA topoisomerase 2-alpha TOP2A 0.01
4674 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase cumD 0.0097
1656 CYP2B protein CYP2B 0.0097
136 Estrogen receptor ESR1 0.0097
833 Organic cation/carnitine transporter 1 SLC22A4 0.0096
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0094
632 Alpha-1B adrenergic receptor ADRA1B 0.0092
1729 Solute carrier family 22 member 6 SLC22A6 0.0092
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0092
3939 Amine oxidase [flavin-containing] B MAOB 0.0091
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.009
885 5-hydroxytryptamine 1B receptor HTR1B 0.009
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0089
3947 Xanthine dehydrogenase/oxidase XDH 0.0088
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0088
1178 Adenosine A2a receptor ADORA2A 0.0084
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0083
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0083
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0082
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0082
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0081
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0081
776 Bile salt export pump ABCB11 0.0079
6220 Aryl hydrocarbon receptor AHR 0.0078
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0078
122 P2Y purinoceptor 12 P2RY12 0.0078
320 5-hydroxytryptamine 1A receptor HTR1A 0.0078
146 Androgen receptor AR 0.0077
725 5-hydroxytryptamine 1D receptor HTR1D 0.0077
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0076
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0076
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0076
731 HIV-1 protease HIV-1 protease 0.0073
131 Synaptic vesicular amine transporter SLC18A2 0.0071
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0071
174 Sigma 1-type opioid receptor SIGMAR1 0.007
193 Beta-1 adrenergic receptor ADRB1 0.0067
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0067
16 Adenosine A1 receptor ADORA1 0.0066
260 Cytochrome P450 51 ERG11 0.0065
761 Cytochrome P450 51 ERG11 0.0065
3163 Cytochrome P450 51 cyp51 0.0065
85 Growth hormone receptor GHR 0.0065
789 Alpha-1D adrenergic receptor ADRA1D 0.0064
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0064
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0063
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0063
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0063
818 50S ribosomal protein L10 rplJ 0.0063
482 Glycine receptor subunit alpha-1 GLRA1 0.0062
629 Alpha-2B adrenergic receptor ADRA2B 0.0062
1757 Myeloperoxidase MPO 0.0061
871 Glucocorticoid receptor NR3C1 0.0061
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0061
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.006
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.006
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.006
847 Mu-type opioid receptor OPRM1 0.0059
6142 Solute carrier family 22 member 8 SLC22A8 0.0059
436 5-hydroxytryptamine 2B receptor HTR2B 0.0059
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0058
1517 Beta-3 adrenergic receptor ADRB3 0.0058
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0057
2164 Multidrug resistance-associated protein 4 ABCC4 0.0057
4120 NADPH--cytochrome P450 reductase POR 0.0055
6143 Solute carrier family 22 member 7 SLC22A7 0.0054
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0053
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0052
4604 Liver carboxylesterase 1 CES1 0.0052
571 Melatonin receptor type 1A MTNR1A 0.0052
362 Melatonin receptor type 1B MTNR1B 0.0052
737 Mineralocorticoid receptor NR3C2 0.0052
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0051
537 ATP synthase delta chain, mitochondrial ATP5D 0.005
378 Alpha-2C adrenergic receptor ADRA2C 0.005
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0049
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0049
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0048
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0048
6014 Cytochrome P450 2A13 CYP2A13 0.0047
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0047
6136 Multidrug resistance-associated protein 5 ABCC5 0.0047
696 Kappa-type opioid receptor OPRK1 0.0047
504 Mast/stem cell growth factor receptor KIT 0.0047
614 Progesterone receptor PGR 0.0047
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0046
705 Glutamate receptor 1 GRIA1 0.0046
4784 Beta-mannosidase manB 0.0046
6695 Beta-mannosidase BT_0458 0.0046
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0045
777 Tumor necrosis factor TNF 0.0044
869 Estrogen receptor beta ESR2 0.0044
6137 Multidrug resistance-associated protein 6 ABCC6 0.0043
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0043
232 Corticosteroid-binding globulin SERPINA6 0.0043
467 Delta-type opioid receptor OPRD1 0.0042
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0042
714 Glutathione reductase, mitochondrial GSR 0.0042
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0042
1010 Cytochrome P450 51A1 CYP51A1 0.0042
3480 Mannan endo-1,4-beta-mannosidase manA 0.0041
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.004
432 D(4) dopamine receptor DRD4 0.004
2998 Sialic acid-binding Ig-like lectin 7 SIGLEC7 0.004
6020 Aldehyde oxidase AOX1 0.0039
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0039
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0039
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0039
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0039
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0038
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0038
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0038
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
94 5-hydroxytryptamine 4 receptor HTR4 0.0038
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0037
26 Vascular endothelial growth factor receptor 3 FLT4 0.0037
427 Substance-P receptor TACR1 0.0037
511 5-hydroxytryptamine 1F receptor HTR1F 0.0037
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0036
921 Glutamate receptor 2 GRIA2 0.0036
4787 Envelope glycoprotein gp160 env 0.0036
4820 Envelope glycoprotein gp160 env 0.0036
5727 Envelope glycoprotein gp160 env 0.0036
756 Sex hormone-binding globulin SHBG 0.0036
144 Hemoglobin subunit alpha HBA1 0.0036
32 Vascular endothelial growth factor receptor 1 FLT1 0.0035
904 Glutathione S-transferase P GSTP1 0.0035
5998 Toll-like receptor 8 TLR8 0.0035
273 Apoptosis regulator Bcl-2 BCL2 0.0034
2297 Genome polyprotein Not Available 0.0034
2322 Genome polyprotein Not Available 0.0034
2694 Genome polyprotein Not Available 0.0034
2719 Genome polyprotein Not Available 0.0034
2860 Genome polyprotein Not Available 0.0034
2928 Genome polyprotein Not Available 0.0034
3160 Genome polyprotein Not Available 0.0034
3260 Genome polyprotein Not Available 0.0034
4783 Genome polyprotein Not Available 0.0034
5726 Genome polyprotein Not Available 0.0034
5779 Genome polyprotein Not Available 0.0034
5867 Genome polyprotein Not Available 0.0034
6253 Genome polyprotein Not Available 0.0034
6301 Genome polyprotein Not Available 0.0034
6380 Genome polyprotein Not Available 0.0034
6381 Genome polyprotein Not Available 0.0034
6437 Genome polyprotein Not Available 0.0034
6520 Genome polyprotein Not Available 0.0034
6521 Genome polyprotein Not Available 0.0034
6652 Genome polyprotein Not Available 0.0034
6734 Genome polyprotein Not Available 0.0034
6735 Genome polyprotein Not Available 0.0034
6736 Genome polyprotein Not Available 0.0034
6737 Genome polyprotein Not Available 0.0034
6738 Genome polyprotein Not Available 0.0034
6739 Genome polyprotein Not Available 0.0034
6744 Genome polyprotein Not Available 0.0034
6748 Genome polyprotein Not Available 0.0034
6894 Genome polyprotein Not Available 0.0034
6898 Genome polyprotein Not Available 0.0034
565 Extracellular calcium-sensing receptor CASR 0.0034
712 Tubulin alpha chain TUB1 0.0034
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0034
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0034
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0034
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0033
716 5-hydroxytryptamine 7 receptor HTR7 0.0033
228 Beta platelet-derived growth factor receptor PDGFRB 0.0033
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0033
4122 Histone deacetylase 2 HDAC2 0.0033
3426 Glutamine synthetase glnA 0.0033
3987 Glutamine synthetase GLUL 0.0033
613 Atrial natriuretic peptide receptor A NPR1 0.0033
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0032
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0032
6146 High affinity copper uptake protein 1 SLC31A1 0.0032
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0032
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0031
6031 Cytochrome P450 3A43 CYP3A43 0.0031
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0031
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0031
6148 Multidrug resistance-associated protein 7 ABCC10 0.0031
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0031
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0031
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0031
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0031
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0031
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0031
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0031
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0031
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.003
2207 Rhodopsin RHO 0.003
3437 Eosinophil lysophospholipase CLC 0.003
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.003
259 Microsomal triglyceride transfer protein large subunit MTTP 0.003
563 Thyroid peroxidase TPO 0.003
173 Toll-like receptor 7 TLR7 0.003
117 Sterol O-acyltransferase 1 SOAT1 0.003
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.003
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0029
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0029
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0029
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0029
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0029
908 Glutathione S-transferase theta-1 GSTT1 0.0029
992 Protein tyrosine kinase 2 beta PTK2B 0.0028
407 Vascular endothelial growth factor receptor 2 KDR 0.0028
163 D(1B) dopamine receptor DRD5 0.0028
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0028
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0028
6044 Serum paraoxonase/lactonase 3 PON3 0.0028
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0028
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0028
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0028
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0027
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
6432 Transporter snf 0.0027
811 Translocator protein TSPO 0.0027
1353 DNA topoisomerase 1 TOP1 0.0027
3552 DNA topoisomerase 1 topA 0.0027
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0026
6163 Copper-transporting ATPase 2 ATP7B 0.0026
6165 Copper-transporting ATPase 1 ATP7A 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
6131 Carbonic anhydrase 14 CA14 0.0026
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0026
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0026
284 DNA-directed RNA polymerase beta chain rpoB 0.0026
5773 DNA-directed RNA polymerase beta chain rpoB 0.0026
891 Dihydropteroate synthase folP 0.0025
5359 Dihydropteroate synthase folP 0.0025
7175 Dihydropteroate synthase sulI 0.0025
5880 Thrombopoietin receptor MPL 0.0025
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0024
6070 Nischarin NISCH 0.0024
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0024
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.0023
844 Epidermal growth factor receptor EGFR 0.0023
3957 Adenosine deaminase ADA 0.0023
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0023
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0022
6182 Cytochrome P450 2J2 CYP2J2 0.0022
4785 Ig gamma-1 chain C region IGHG1 0.0022
896 Glutathione S-transferase Mu 1 GSTM1 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
1618 High affinity nerve growth factor receptor NTRK1 0.0021
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
1243 Cathepsin D CTSD 0.0021
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.002
373 Transthyretin TTR 0.002
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.002
1820 Beta-nerve growth factor NGF 0.002
4228 Keratin, type II cytoskeletal 7 KRT7 0.002
3932 Glutathione S-transferase A2 GSTA2 0.0019
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0019
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0019
6138 Multidrug resistance protein 3 ABCB4 0.0019
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0019
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0019
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0019
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0019
380 Cytochrome P450 17A1 CYP17A1 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
251 Alcohol dehydrogenase 1A ADH1A 0.0018
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0018
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0018
33 Cystine/glutamate transporter SLC7A11 0.0018
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0018
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0018
7 Nitric oxide synthase, inducible NOS2 0.0017
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0017
820 Glycine receptor subunit alpha-2 GLRA2 0.0017
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0017
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0017
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0017
3927 Choline transporter-like protein 3 SLC44A3 0.0017
861 Choline kinase alpha CHKA 0.0017
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0017
769 High-affinity choline transporter 1 SLC5A7 0.0017
700 Choline dehydrogenase, mitochondrial CHDH 0.0017
1686 Choline transporter-like protein 1 SLC44A1 0.0017
3926 Choline transporter-like protein 2 SLC44A2 0.0017
3925 Choline transporter-like protein 4 SLC44A4 0.0017
576 Choline O-acetyltransferase CHAT 0.0017
3922 Phospholipase D2 PLD2 0.0017
3924 Phospholipase D1 PLD1 0.0017
780 Retinoic acid receptor RXR-gamma RXRG 0.0017
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0017
1192 Sulfotransferase 1A1 SULT1A1 0.0017
1262 Corticotropin-lipotropin POMC 0.0017
6085 Fatty acid-binding protein, intestinal FABP2 0.0017
823 Fibroblast growth factor receptor 2 FGFR2 0.0017
84 Nuclear receptor 0B1 NR0B1 0.0017
1256 5-hydroxytryptamine 6 receptor HTR6 0.0017
1648 Elastin ELN 0.0017
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0017
1024 Solute carrier family 22 member 11 SLC22A11 0.0017
444 Alcohol dehydrogenase 1B ADH1B 0.0017
1830 5'-nucleotidase NT5E 0.0016
390 Adenosine A3 receptor ADORA3 0.0016
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0016
88 Retinoic acid receptor RXR-beta RXRB 0.0016
162 Retinoic acid receptor gamma-1 RARG 0.0015
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0015
581 Cytochrome P450 2R1 CYP2R1 0.0015
70 Type-1 angiotensin II receptor AGTR1 0.0015
2499 Tubulin beta-2C chain TUBB2C 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
29 Tubulin beta-1 chain TUBB1 0.0014
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0014
161 Tubulin beta chain TUBB 0.0014
312 Tubulin beta chain TUB2 0.0014
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0014
517 Alcohol dehydrogenase 1C ADH1C 0.0014
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0014
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0014
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0014
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0014
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0014
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0014
1992 Vitamin D-binding protein GC 0.0014
6102 Arylamine N-acetyltransferase 2 NAT2 0.0014
936 Ephrin type-A receptor 2 EPHA2 0.0014
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0014
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0014
319 Opioid receptor, sigma 1 OPRS1 0.0014
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0014
2091 Endoplasmin HSP90B1 0.0014
5934 Cytochrome P450 26A1 CYP26A1 0.0014
6859 Protein S100-A4 S100A4 0.0014
2449 Tubulin alpha-3 chain TUBA1A 0.0014
518 Peroxidase/catalase T katG 0.0014
751 Potassium channel subfamily K member 6 KCNK6 0.0013
1039 Histone deacetylase 9 HDAC9 0.0013
1630 Integrin beta-2 ITGB2 0.0013
1360 Sphingomyelin phosphodiesterase SMPD1 0.0013
543 Penicillin-binding protein 1B mrcB 0.0013
6186 Penicillin-binding protein 1B ponB 0.0013
6822 Penicillin-binding protein 1b pbp1b 0.0013
6844 Penicillin-binding protein 1b pbp1b 0.0013
645 Penicillin-binding protein 1A mrcA 0.0013
5805 Penicillin-binding protein 1A ponA 0.0013
6185 Penicillin-binding protein 1A mrcA 0.0013
6799 Penicillin-binding protein 1A pbpA 0.0013
3937 Fatty-acid amide hydrolase FAAH 0.0013
159 Penicillin-binding protein 2B penA 0.0013
6121 Penicillin-binding protein 2B penA 0.0013
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
291 Nitric-oxide synthase, endothelial NOS3 0.0012
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0012
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0012
4498 Ornithine cyclodeaminase PP3533 0.0012
172 Potassium channel subfamily K member 1 KCNK1 0.0012
4311 tRNA TRDMT1 0.0012
4325 tRNA trmD 0.0012
4328 tRNA trmD 0.0012
165 FL cytokine receptor FLT3 0.0012
5449 Hypothetical gliding protein mglB 0.0012
5443 UPF0189 protein ymdB ymdB 0.0012
5440 UPF0067 protein yebR yebR 0.0012
4705 Manganese catalase Not Available 0.0012
5439 33 kDa chaperonin hslO 0.0012
5446 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase HI_1679 0.0012
2720 Copper-containing nitrite reductase nirK 0.0012
5448 Ribonuclease Z rnz 0.0012
3781 Thiol:disulfide interchange protein dsbC precursor dsbC 0.0012
5447 Lethal(3)malignant brain tumor-like protein L3MBTL1 0.0012
5454 Internalin-A inlA 0.0012
332 Beta-lactamase blaZ 0.0012
2478 Beta-lactamase ampC 0.0012
2613 Beta-lactamase ampC 0.0012
2635 Beta-lactamase ampC 0.0012
2700 Beta-lactamase penP 0.0012
5445 Beta-lactamase blaB 0.0012
6019 Beta-lactamase SHV-7 0.0012
6701 Beta-lactamase cphA 0.0012
6141 Sodium/bile acid cotransporter SLC10A1 0.0012
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0012
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0012
1629 Transcription factor AP-1 JUN 0.0012
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0012
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0012
828 Phenylalanine-4-hydroxylase PAH 0.0011
3109 Phenylalanine-4-hydroxylase phhA 0.0011
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0011
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0011
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0011
4238 50S ribosomal protein L4 rplD 0.0011
5578 50S ribosomal protein L4 rplD 0.0011
6173 50S ribosomal protein L4 rplD 0.0011
6219 50S ribosomal protein L4 rplD 0.0011
6043 Putative G-protein coupled receptor 44 GPR44 0.0011
719 Retinoic acid receptor responder protein 1 RARRES1 0.0011
770 Retinoic acid-induced protein 3 GPRC5A 0.0011
4608 Putative cytochrome P450 SCO1207 0.0011
4963 Putative cytochrome P450 SCO2884 0.0011
6254 Putative cytochrome P450 SCO6998 0.0011
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0011
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0011
4192 DNA topoisomerase 2-beta TOP2B 0.0011
3736 Glyceraldehyde-3-phosphate dehydrogenase A gapA 0.0011
856 Vitamin D3 receptor VDR 0.0011
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0011
5450 Prolyl endopeptidase Pep pep 0.0011
634 Squalene monooxygenase SQLE 0.001
7196 Squalene monooxygenase ERG1 0.001
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.001
3356 Diaminopimelate decarboxylase lysA 0.001
239 Coagulation factor X F10 0.001
4237 50S ribosomal protein L22 rplV 0.001
597 Dihydropteridine reductase QDPR 0.001
4771 Dissimilatory copper-containing nitrite reductase nir 0.001
3274 Hydroxylamine reductase hcp 0.001
4804 Hydroxylamine reductase hcp 0.001
2714 Chorismate mutase aroH 0.001
4611 Chorismate mutase aroG 0.001
1714 Mitogen-activated protein kinase 3 MAPK3 0.001
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.001
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.001
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.001
5798 Mitogen-activated protein kinase 11 MAPK11 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
295 Carbonic anhydrase 1 CA1 0.001
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.001
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.001
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.001
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.001
569 Retinal dehydrogenase 2 ALDH1A2 0.001
3462 Tyrosine-protein kinase transforming protein Abl ABL 0.001
267 Plasminogen activator inhibitor 1 SERPINE1 0.001
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.001
3399 Limonene-1,2-epoxide hydrolase limA 0.001
3697 Bifunctional protein glmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase glmU 0.001
76 Nitric-oxide synthase, brain NOS1 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
229 Retinoic acid receptor beta RARB 0.0009
5180 L(+)-mandelate dehydrogenase mdlB 0.0009
577 Argininosuccinate lyase ASL 0.0009
611 Retinal dehydrogenase 1 ALDH1A1 0.0009
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0009
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0009
1268 Neuropeptide S receptor NPSR1 0.0009
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
3917 Methylenetetrahydrofolate reductase MTHFR 0.0009
3500 Putative family 31 glucosidase yicI yicI 0.0009
4878 Glycoprotein hormones alpha chain CGA 0.0009
1052 Cytotoxic T-lymphocyte protein 4 CTLA4 0.0009
1072 Granzyme B GZMB 0.0009
4889 Ig epsilon chain C region IGHE 0.0009
4877 Beta-mannanase man 0.0009
4871 Endo-beta-N-acetylglucosaminidase F3 endOF3 0.0009
4189 Alpha-galactosidase A GLA 0.0009
4850 Beta-2-glycoprotein 1 APOH 0.0009
4880 Membrane cofactor protein CD46 0.0009
4856 CD209 antigen CD209 0.0009
1354 Beta-glucuronidase GUSB 0.0009
757 Fusion glycoprotein F0 F 0.0009
4875 Fusion glycoprotein F0 F 0.0009
4869 Major capsid protein A430L 0.0009
4852 Reticulon-4 receptor RTN4R 0.0009
4845 ADAM 33 ADAM33 0.0009
1563 Platelet glycoprotein Ib alpha chain GP1BA 0.0009
442 Envelope glycoprotein gp41 0.0009
4859 Envelope glycoprotein env 0.0009
4882 Dipeptidyl aminopeptidase-like protein 6 DPP6 0.0009
4721 Beta-1,4-mannanase manA 0.0009
3352 Structural polyprotein Not Available 0.0009
3628 Structural polyprotein Not Available 0.0009
4892 Structural polyprotein Not Available 0.0009
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0009
365 Dihydrofolate reductase DHFR 0.0009
2381 Dihydrofolate reductase DFR1 0.0009
2833 Dihydrofolate reductase Not Available 0.0009
2931 Dihydrofolate reductase folA 0.0009
3544 Dihydrofolate reductase folA 0.0009
3682 Dihydrofolate reductase folA 0.0009
6642 Dihydrofolate reductase folA 0.0009
6756 Dihydrofolate reductase dfrA 0.0009
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0009
1615 Chymase CMA1 0.0009
6221 Steroid hormone receptor ERR1 ESRRA 0.0009
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0009
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0008
459 Retinoic acid receptor RXR-alpha RXRA 0.0008
2981 Phospholipase A2, membrane associated PLA2G2A 0.0008
528 5-hydroxytryptamine 1E receptor HTR1E 0.0008
2236 Casein kinase II subunit alpha CSNK2A1 0.0008
2597 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] glmS 0.0008
6073 Potassium channel subfamily K member 9 KCNK9 0.0008
6072 Potassium channel subfamily K member 3 KCNK3 0.0008
3830 Calreticulin CALR 0.0008
6167 Organic solute transporter subunit beta OSTB 0.0008
6166 Organic solute transporter subunit alpha OSTA 0.0008
287 Beta-1,4-galactosyltransferase 1 B4GALT1 0.0008
952 Dipeptidyl peptidase 4 DPP4 0.0008
4861 Interleukin-6 receptor alpha chain IL6R 0.0008
793 T-cell surface antigen CD2 CD2 0.0008
119 Carcinoembryonic antigen-related cell adhesion molecule 1 CEACAM1 0.0008
4193 Atrial natriuretic peptide clearance receptor NPR3 0.0008
3837 Cytokine receptor common beta chain CSF2RB 0.0008
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0008
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
6034 Hydroxyindole O-methyltransferase ASMT 0.0008
6035 Nuclear receptor ROR-beta RORB 0.0008
6036 Eosinophil peroxidase EPX 0.0008
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0008
3856 Fibroblast growth factor receptor 3 FGFR3 0.0008
976 Platelet glycoprotein IX GP9 0.0008
5787 Angiopoietin-1 receptor TEK 0.0008
738 Monocarboxylate transporter 1 SLC16A1 0.0008
1374 Natriuretic peptides B NPPB 0.0008
1827 Gap junction alpha-1 protein GJA1 0.0008
1908 Vascular cell adhesion protein 1 VCAM1 0.0008
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
4103 Proteasome subunit beta type 2 PSMB2 0.0007
4102 Proteasome subunit beta type 5 PSMB5 0.0007
4101 Proteasome subunit beta type 1 PSMB1 0.0007
1063 Signal transducer and activator of transcription 5B STAT5B 0.0007
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0007
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
3810 Catechol O-methyltransferase COMT 0.0007
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0007
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0007
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0007
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0007
6168 Solute carrier family 22 member 16 SLC22A16 0.0007
814 Ryanodine receptor 1 RYR1 0.0007
822 Aldose reductase AKR1B1 0.0007
3809 Estrogen-related receptor gamma ESRRG 0.0007
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0007
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
469 Annexin A1 ANXA1 0.0007
4890 Hemagglutinin HA 0.0007
6566 Hemagglutinin Not Available 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
1379 Interleukin-12 subunit beta IL12B 0.0007
4857 Zinc-alpha-2-glycoprotein AZGP1 0.0007
6858 Inactive carboxylesterase 4 CES1P1 0.0007
765 Indoleamine 2,3-dioxygenase IDO1 0.0007
1184 Interferon beta IFNB1 0.0007
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0007
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0007
4225 Uridine phosphorylase 1 UPP1 0.0007
6120 Cation-independent mannose-6-phosphate receptor IGF2R 0.0007
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0006
18 High affinity immunoglobulin epsilon receptor subunit alpha FCER1A 0.0006
554 Low-density lipoprotein receptor LDLR 0.0006
268 Adenosine A2b receptor ADORA2B 0.0006
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
852 Heparin cofactor 2 SERPIND1 0.0006
484 Tyrosine-protein kinase ABL2 ABL2 0.0006
1859 Prostatic acid phosphatase ACPP 0.0006
3444 Cyanovirin-N Not Available 0.0006
3140 Hemagglutinin-neuraminidase HN 0.0006
3609 Hemagglutinin-neuraminidase HN 0.0006
595 Fibrinogen alpha chain FGA 0.0006
3258 Mannosyl-oligosaccharide alpha-1,2-mannosidase MSDC 0.0006
183 Vascular endothelial growth factor A VEGFA 0.0006
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
1864 RET proto-oncogene RET 0.0006
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0006
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0006
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0006
4666 Fucose-binding lectin PA-IIL lecB 0.0005
2372 Bifunctional tail protein 9 0.0005
1275 Estrogen sulfotransferase SULT1E1 0.0005
153 Dopamine beta-hydroxylase DBH 0.0005
3639 Thymidine phosphorylase deoA 0.0005
3936 Thymidine phosphorylase TYMP 0.0005
760 Fibroblast growth factor 1 FGF1 0.0005
798 Osteocalcin BGLAP 0.0005
2577 Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase MAN1B1 0.0005
1050 Bile salt sulfotransferase SULT2A1 0.0005
3814 Complement C1r subcomponent C1R 0.0005
64 Neuraminidase NA 0.0005
641 Neuraminidase NA 0.0005
2676 Neuraminidase NA 0.0005
3026 Neuraminidase NA 0.0005
3519 Neuraminidase NA 0.0005
6007 Neuraminidase NA 0.0005
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0005
1439 Lactotransferrin LTF 0.0005
1782 Neutrophil gelatinase-associated lipocalin LCN2 0.0005
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0005
309 Antithrombin-III SERPINC1 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
369 Coagulation factor VII F7 0.0005
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0005
6149 Solute carrier family 22 member 10 SLC22A10 0.0004
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0004
2430 Chondroitinase B cslB 0.0004
6307 Ig gamma-2 chain C region IGHG2 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
2581 Chondroitinase AC cslA 0.0004
6847 Lactase-phlorizin hydrolase LCT 0.0004
24 Thymidylate synthase TMP1 0.0004
359 Thymidylate synthase TYMS 0.0004
2626 Thymidylate synthase thyA 0.0004
2729 Thymidylate synthase thyA 0.0004
5352 Thymidylate synthase THYA 0.0004
6500 Phospholipase A2 PLA2G1B 0.0004
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0004
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0004
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0004
4925 Cytochrome c-type protein SHP shp 0.0003
4954 Soluble cytochrome b558 Not Available 0.0003
4916 Cyanoglobin glbN 0.0003
4994 Hemoglobin-like protein HbO glbO 0.0003
4915 Cytochrome c-550 psbV 0.0003
4959 Cytochrome c-550 psbV 0.0003
5216 Cytochrome c-550 psbV 0.0003
4947 Bacterial hemoglobin vhb 0.0003
4975 Cytochrome c-556 RPA3973 0.0003
4984 Neuroglobin NGB 0.0003
4943 Cytochrome c6 petJ 0.0003
3116 Bacterioferritin bfr 0.0003
4906 Bacterioferritin bfr 0.0003
4965 Bacterioferritin bfr 0.0003
4934 Cytochrome c-551 nirM 0.0003
5218 Cytochrome c-551 nirM 0.0003
4905 Cytochrome c2 Not Available 0.0003
4939 Cytochrome c2 cycA 0.0003
4964 Cytochrome c2 cycA 0.0003
4979 Cytochrome c2 cycA 0.0003
6673 Cytochrome c2 cycA 0.0003
4910 Cytoglobin CYGB 0.0003
4907 Cytochrome c-L moxG 0.0003
6865 Cytochrome c-L moxG 0.0003
4981 Iron-starvation protein PigA pigA 0.0003
4936 Cytochrome c2 iso-2 Not Available 0.0003
4909 CooA protein cooA 0.0003
5000 HemO hemO 0.0003
4998 Hemoglobin-like protein yjbI yjbI 0.0003
644 Heme oxygenase 2 HMOX2 0.0003
4982 Heme oxygenase 2 pbsA2 0.0003
4942 Diheme cytochrome c napB napB 0.0003
4935 Cytochrome c-554 cycA1 0.0003
4972 P450cin cinA 0.0003
4971 Nonaheme cytochrome c hmcA 0.0003
4961 Hemophore HasA hasA 0.0003
4976 Apocytochrome f petA 0.0003
6407 Apocytochrome f petA 0.0003
4903 Methyl-accepting chemotaxis protein Tar4 0.0003
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0003
4999 Cytochrome P450 165B3 CYP165B3 0.0003
4764 Cytochrome P450 165C4 CYP165C4 0.0003
4960 Putative cytochrome P450-family protein SCO7417 0.0003
4931 Cytochrome P450 167A1 CYP167A1 0.0003
4926 Heme-based aerotactic transducer hemAT hemAT 0.0003
4904 Cytochrome c family protein GSU1996 0.0003
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0003
4937 Cytochrome oxidase subunit II rcoxA 0.0003
4993 Hydroxylamine oxidoreductase hao1 0.0003
4922 Cytochrome c, putative SO_4144 0.0003
4989 Cytochrome c551 peroxidase ccp 0.0003
5222 Cytochrome c551 peroxidase ccpA 0.0003
3093 Catalase HPII katE 0.0003
4952 Catalase/peroxidase katA 0.0003
164 Histamine H4 receptor HRH4 0.0003
54 Prothrombin F2 0.0003
4920 Peroxidase/catalase katG 0.0002
4948 Cytochrome c-553 Not Available 0.0002
4923 Cytochrome c3 DvMF_2499 0.0002
4945 Cytochrome c3 Not Available 0.0002
4949 Cytochrome c3 DVU_3171 0.0002
4968 Cytochrome c3 cytc3 0.0002
4997 Cytochrome c3 SO_2727 0.0002
5219 Cytochrome c3 cyd 0.0002
4902 Nine-heme cytochrome c Ddes_2038 0.0002
2119 Cytochrome b5 CYB5A 0.0002
3189 High-molecular-weight cytochrome c hmcA 0.0002
4990 PpcA ppcA 0.0002
3375 Acidic cytochrome c3 Not Available 0.0002
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0002
2915 Sensor protein fixL fixL 0.0002
4944 Sensor protein fixL fixL 0.0002
4988 Sulfite oxidase, mitochondrial SUOX 0.0002
4385 Cytochrome c' Not Available 0.0002
4967 Cytochrome c' cycA 0.0002
5038 Cytochrome c' Not Available 0.0002
5223 Cytochrome c' cycP 0.0002
3570 Cytochrome P450 152A1 cypC 0.0002
4813 Heme oxygenase hmuO 0.0002
5769 Heme oxygenase Not Available 0.0002
4037 Hypothetical protein GPX1 0.0002
4297 Hypothetical protein SP_1951 0.0002
4521 Hypothetical protein BC_2969 0.0002
4540 Hypothetical protein TM_1070 0.0002
4555 Hypothetical protein MT1739 0.0002
4569 Hypothetical protein mshD 0.0002
4578 Hypothetical protein PA3270 0.0002
4747 Hypothetical protein PA3967 0.0002
5177 Hypothetical protein TM_0096 0.0002
5194 Hypothetical protein PA1204 0.0002
5240 Hypothetical protein Rv2991 0.0002
5370 Hypothetical protein TM_1158 0.0002
5710 Hypothetical protein Tb927.5.1360 0.0002
4289 Cytochrome P450 TT_P0059 0.0002
6262 Cytochrome P450 staP 0.0002
4992 Cytochrome c peroxidase Not Available 0.0002
2230 Catalase CAT 0.0002
3249 Catalase katA 0.0002
3625 Catalase katA 0.0002
4539 Catalase katA 0.0002
4941 Catalase katB 0.0002
3411 Cytochrome P450 121 cyp121 0.0002
3670 Soluble cytochrome b562 precursor cybC 0.0002
3291 Cytochrome c-552 cycA 0.0002
4927 Cytochrome c-552 nrfA 0.0002
4938 Cytochrome c-552 cycA 0.0002
4953 Cytochrome c-552 nrfA 0.0002
5217 Cytochrome c-552 cycM 0.0002
2617 Nitric oxide synthase oxygenase nos 0.0002
2701 Nitric oxide synthase oxygenase nos 0.0002
4386 Hemoglobin-like protein HbN glbN 0.0002
3102 Flavohemoprotein hmp 0.0002
4969 Flavohemoprotein hmp 0.0002
3127 Nitrite reductase nirS 0.0002
3284 Nitrite reductase nirS 0.0002
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0002
3221 Cytochrome c4 cc4 0.0002
2972 6-deoxyerythronolide B hydroxylase eryF 0.0002
358 Cystathionine beta-synthase CBS 0.0002
1507 Cytochrome c CYCS 0.0002
693 Hemoglobin subunit beta HBB 0.0002
6268 Hydroxyacid oxidase 1 HAO1 0.0001
810 Heme oxygenase 1 HMOX1 0.0001
3391 Heme oxygenase 1 pbsA1 0.0001
2298 Cytochrome P450-cam camC 0.0001
↑