DT-Web

DB00242 - Cladribine


Identification
Name Cladribine
Accession Number DB00242 (APRD00260)
Type small molecule
Description An antineoplastic agent used in the treatment of lymphoproliferative diseases including hairy-cell leukemia. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 285.687
Groups approved
Monoisotopic Weight 285.062866982
Pharmacology
Indication For the treatment of active hairy cell leukemia (leukemic reticuloendotheliosis) as defined by clinically significant anemia, neutropenia, thrombocytopenia, or disease-related symptoms. Also used as an alternative agent for the treatment of chronic lymphocytic leukemia (CLL), low-grade non-Hodgkin's lymphoma, and cutaneous T-cell lymphoma.
Mechanism of action Cladribine is structurally related to fludarabine and pentostatin but has a different mechanism of action. Although the exact mechanism of action has not been fully determined, evidence shows that cladribine is phosphorylated by deoxycytidine kinase to the nucleotidecladribine triphosphate (CdATP; 2-chloro-2?-deoxyadenosine 5?-triphosphate), which accumulates and is incorporated into DNA in cells such as lymphocytes that contain high levels of deoxycytidine kinase and low levels of deoxynucleotidase, resulting in DNA strand breakage and inhibition of DNA synthesis and repair. High levels of CdATP also appear to inhibit ribonucleotide reductase, which leads to an imbalance in triphosphorylated deoxynucleotide (dNTP) pools and subsequent DNA strand breaks, inhibition of DNA synthesis and repair, nicotinamide adenine dinucleotide (NAD) and ATP depletion, and cell death. Unlike other antimetabolite drugs, cladribine has cytotoxic effects on resting as well as proliferating lymphocytes. However, it does cause cells to accumulate at the G1/S phase junction, suggesting that cytotoxicity is associated with events critical to cell entry into S phase. It also binds purine nucleoside phosphorylase (PNP), however no relationship between this binding and a mechanism of action has been established.
Absorption Oral bioavailability is 34 to 48%.
Protein binding 20%
Biotransformation Metabolized in all cells with deoxycytidine kinase activity to 2-chloro-2'-deoxyadenosine-5'-triphosphate
Route of elimination Not Available
Toxicity Symptoms of overdose include irreversible neurologic toxicity (paraparesis/quadriparesis), acute nephrotoxicity, and severe bone marrow suppression resulting in neutropenia, anemia and thrombocytopenia.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions
Drug Mechanism of interaction
Leflunomide Immunosuppressants such as cladribine may enhance the adverse/toxic effect of leflunomide. Specifically, the risk for hematologic toxicity such as pancytopenia, agranulocytosis, and/or thrombocytopenia may be increased. Consider eliminating the use of a leflunomide loading dose in patients who are receiving other immunosuppressants in order to reduce the risk for serious adverse events such as hematologic toxicity. Also, patients receiving both leflunomide and another immunosuppressive medication should be monitored for bone marrow suppression at least monthly throughout the duration of concurrent therapy.
Natalizumab Immunosuppressants such as cladribine may enhance the adverse/toxic effect of natalizumab. Specifically, the risk of concurrent infection may be increased. Patients receiving natalizumab should not use concurrent immunosuppressants, and patients receiving chronic corticosteroids prior to natalizumab should be tapered off of steroids prior to starting natalizumab.
Pimecrolimus Pimecrolimus may enhance the adverse/toxic effect of immunosuppressants such as cladribine. Avoid use of pimecrolimus cream in patients receiving immunosuppressants.
Roflumilast Roflumilast may enhance the immunosuppressive effect of immunosuppressants such as cladribine. The Canadian roflumilast product monograph recommends avoiding concurrent use of roflumilast with any immunosuppressant medications due to the antiinflammatory/immune altering effects of roflumilast and the lack of relevant clinical experience with such use. Of note, this recommendation to avoid concurrent use does not apply to either inhaled corticosteroids (which have much more limited systemic immune-suppressing actions) or short-term systemic corticosteroid use. U.S. prescribing information does not contain this warning; but it appears prudent to avoid this combination when possible.
Tacrolimus Tacrolimus (Topical) may enhance the adverse/toxic effect of immunosuppressants such as tacrolimus. Avoid use of tacrolimus ointment in patients receiving immunosuppressants.
Trastuzumab Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Food Interactions
  • Echinacea should be used with caution, if at all, in patients receiving therapeutic immunosuppressants. Monitor for reduced efficacy of the immunosuppressant during concomitant use.

Targets


Ribonucleoside-diphosphate reductase large subunit
Name Ribonucleoside-diphosphate reductase large subunit
Gene Name RRM1
Pharmacological action yes
Actions inhibitor
References
  • Sampat K, Kantarjian H, Borthakur G: Clofarabine: emerging role in leukemias. Expert Opin Investig Drugs. 2009 Oct;18(10):1559-64. - Pubmed
  • Kantarjian HM, Jeha S, Gandhi V, Wess M, Faderl S: Clofarabine: past, present, and future. Leuk Lymphoma. 2007 Oct;48(10):1922-30. - Pubmed
  • Zhenchuk A, Lotfi K, Juliusson G, Albertioni F: Mechanisms of anti-cancer action and pharmacology of clofarabine. Biochem Pharmacol. 2009 Dec 1;78(11):1351-9. Epub 2009 Jul 1. - Pubmed
  • Kline JP, Larson RA: Clofarabine in the treatment of acute myeloid leukaemia and acute lymphoblastic leukaemia: a review. Expert Opin Pharmacother. 2005 Dec;6(15):2711-8. - Pubmed
  • Takahashi T, Kanazawa J, Akinaga S, Tamaoki T, Okabe M: Antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) adenine, a novel deoxyadenosine analog, against human colon tumor xenografts by oral administration. Cancer Chemother Pharmacol. 1999;43(3):233-40. - Pubmed
DTHybrid score 1.1398
Ribonucleoside-diphosphate reductase M2 subunit
Name Ribonucleoside-diphosphate reductase M2 subunit
Gene Name RRM2
Pharmacological action yes
Actions inhibitor
References
  • Sampat K, Kantarjian H, Borthakur G: Clofarabine: emerging role in leukemias. Expert Opin Investig Drugs. 2009 Oct;18(10):1559-64. - Pubmed
  • Kantarjian HM, Jeha S, Gandhi V, Wess M, Faderl S: Clofarabine: past, present, and future. Leuk Lymphoma. 2007 Oct;48(10):1922-30. - Pubmed
  • Zhenchuk A, Lotfi K, Juliusson G, Albertioni F: Mechanisms of anti-cancer action and pharmacology of clofarabine. Biochem Pharmacol. 2009 Dec 1;78(11):1351-9. Epub 2009 Jul 1. - Pubmed
  • Kline JP, Larson RA: Clofarabine in the treatment of acute myeloid leukaemia and acute lymphoblastic leukaemia: a review. Expert Opin Pharmacother. 2005 Dec;6(15):2711-8. - Pubmed
  • Takahashi T, Kanazawa J, Akinaga S, Tamaoki T, Okabe M: Antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) adenine, a novel deoxyadenosine analog, against human colon tumor xenografts by oral administration. Cancer Chemother Pharmacol. 1999;43(3):233-40. - Pubmed
DTHybrid score 0.7172
Ribonucleoside-diphosphate reductase subunit M2 B
Name Ribonucleoside-diphosphate reductase subunit M2 B
Gene Name RRM2B
Pharmacological action yes
Actions inhibitor
References
  • Sampat K, Kantarjian H, Borthakur G: Clofarabine: emerging role in leukemias. Expert Opin Investig Drugs. 2009 Oct;18(10):1559-64. - Pubmed
  • Kantarjian HM, Jeha S, Gandhi V, Wess M, Faderl S: Clofarabine: past, present, and future. Leuk Lymphoma. 2007 Oct;48(10):1922-30. - Pubmed
  • Zhenchuk A, Lotfi K, Juliusson G, Albertioni F: Mechanisms of anti-cancer action and pharmacology of clofarabine. Biochem Pharmacol. 2009 Dec 1;78(11):1351-9. Epub 2009 Jul 1. - Pubmed
  • Kline JP, Larson RA: Clofarabine in the treatment of acute myeloid leukaemia and acute lymphoblastic leukaemia: a review. Expert Opin Pharmacother. 2005 Dec;6(15):2711-8. - Pubmed
  • Takahashi T, Kanazawa J, Akinaga S, Tamaoki T, Okabe M: Antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) adenine, a novel deoxyadenosine analog, against human colon tumor xenografts by oral administration. Cancer Chemother Pharmacol. 1999;43(3):233-40. - Pubmed
DTHybrid score 0.8097
DNA
Name DNA
Gene Name Not Available
Pharmacological action yes
Actions other/unknown
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Sampat K, Kantarjian H, Borthakur G: Clofarabine: emerging role in leukemias. Expert Opin Investig Drugs. 2009 Oct;18(10):1559-64. - Pubmed
  • Kantarjian HM, Jeha S, Gandhi V, Wess M, Faderl S: Clofarabine: past, present, and future. Leuk Lymphoma. 2007 Oct;48(10):1922-30. - Pubmed
  • Zhenchuk A, Lotfi K, Juliusson G, Albertioni F: Mechanisms of anti-cancer action and pharmacology of clofarabine. Biochem Pharmacol. 2009 Dec 1;78(11):1351-9. Epub 2009 Jul 1. - Pubmed
  • Kline JP, Larson RA: Clofarabine in the treatment of acute myeloid leukaemia and acute lymphoblastic leukaemia: a review. Expert Opin Pharmacother. 2005 Dec;6(15):2711-8. - Pubmed
  • Hartman WR, Hentosh P: The antileukemia drug 2-chloro-2'-deoxyadenosine: an intrinsic transcriptional antagonist. Mol Pharmacol. 2004 Jan;65(1):227-34. - Pubmed
DTHybrid score Not Available
DNA polymerase alpha catalytic subunit
Name DNA polymerase alpha catalytic subunit
Gene Name POLA1
Pharmacological action yes
Actions inhibitor
References
  • Zhenchuk A, Lotfi K, Juliusson G, Albertioni F: Mechanisms of anti-cancer action and pharmacology of clofarabine. Biochem Pharmacol. 2009 Dec 1;78(11):1351-9. Epub 2009 Jul 1. - Pubmed
  • Kline JP, Larson RA: Clofarabine in the treatment of acute myeloid leukaemia and acute lymphoblastic leukaemia: a review. Expert Opin Pharmacother. 2005 Dec;6(15):2711-8. - Pubmed
  • Takahashi T, Kanazawa J, Akinaga S, Tamaoki T, Okabe M: Antitumor activity of 2-chloro-9-(2-deoxy-2-fluoro-beta-D-arabinofuranosyl) adenine, a novel deoxyadenosine analog, against human colon tumor xenografts by oral administration. Cancer Chemother Pharmacol. 1999;43(3):233-40. - Pubmed
  • Hartman WR, Hentosh P: The antileukemia drug 2-chloro-2'-deoxyadenosine: an intrinsic transcriptional antagonist. Mol Pharmacol. 2004 Jan;65(1):227-34. - Pubmed
DTHybrid score 1.182
DNA polymerase epsilon catalytic subunit A
Name DNA polymerase epsilon catalytic subunit A
Gene Name POLE
Pharmacological action yes
Actions inhibitor
References
  • Zhenchuk A, Lotfi K, Juliusson G, Albertioni F: Mechanisms of anti-cancer action and pharmacology of clofarabine. Biochem Pharmacol. 2009 Dec 1;78(11):1351-9. Epub 2009 Jul 1. - Pubmed
DTHybrid score 0.8025
DNA polymerase epsilon subunit 2
Name DNA polymerase epsilon subunit 2
Gene Name POLE2
Pharmacological action yes
Actions inhibitor
References
  • Zhenchuk A, Lotfi K, Juliusson G, Albertioni F: Mechanisms of anti-cancer action and pharmacology of clofarabine. Biochem Pharmacol. 2009 Dec 1;78(11):1351-9. Epub 2009 Jul 1. - Pubmed
DTHybrid score 0.8031
DNA polymerase epsilon subunit 3
Name DNA polymerase epsilon subunit 3
Gene Name POLE3
Pharmacological action yes
Actions inhibitor
References
  • Zhenchuk A, Lotfi K, Juliusson G, Albertioni F: Mechanisms of anti-cancer action and pharmacology of clofarabine. Biochem Pharmacol. 2009 Dec 1;78(11):1351-9. Epub 2009 Jul 1. - Pubmed
DTHybrid score 0.8042
DNA polymerase epsilon subunit 4
Name DNA polymerase epsilon subunit 4
Gene Name POLE4
Pharmacological action yes
Actions inhibitor
References
  • Zhenchuk A, Lotfi K, Juliusson G, Albertioni F: Mechanisms of anti-cancer action and pharmacology of clofarabine. Biochem Pharmacol. 2009 Dec 1;78(11):1351-9. Epub 2009 Jul 1. - Pubmed
DTHybrid score 0.8042
Purine nucleoside phosphorylase
Name Purine nucleoside phosphorylase
Gene Name PNP
Pharmacological action yes
Actions inducer
References
  • Bzowska A, Kazimierczuk Z: 2-Chloro-2'-deoxyadenosine (cladribine) and its analogues are good substrates and potent selective inhibitors of Escherichia coli purine-nucleoside phosphorylase. Eur J Biochem. 1995 Nov 1;233(3):886-90. - Pubmed
  • Dumontet C, Fabianowska-Majewska K, Mantincic D, Callet Bauchu E, Tigaud I, Gandhi V, Lepoivre M, Peters GJ, Rolland MO, Wyczechowska D, Fang X, Gazzo S, Voorn DA, Vanier-Viornery A, MacKey J: Common resistance mechanisms to deoxynucleoside analogues in variants of the human erythroleukaemic line K562. Br J Haematol. 1999 Jul;106(1):78-85. - Pubmed
  • Dumontet C, Bauchu EC, Fabianowska K, Lepoivre M, Wyczechowska D, Bodin F, Rolland MO: Common resistance mechanisms to nucleoside analogues in variants of the human erythroleukemic line K562. Adv Exp Med Biol. 1999;457:571-7. - Pubmed
  • Takimoto T, Kubota M, Tsuruta S, Kitoh T, Tanizawa A, Akiyama Y, Kiriyama Y, Mikawa H: Changes in sensitivity to anticancer drugs during TPA-induced cellular differentiation in a human T-lymphoblastoid cell line (MOLT-4). Leukemia. 1988 Jul;2(7):443-6. - Pubmed
  • Carson DA, Wasson DB, Lakow E, Kamatani N: Possible metabolic basis for the different immunodeficient states associated with genetic deficiencies of adenosine deaminase and purine nucleoside phosphorylase. Proc Natl Acad Sci U S A. 1982 Jun;79(12):3848-52. - Pubmed
DTHybrid score 1.7907

Enzymes


Deoxycytidine kinase
Name Deoxycytidine kinase
Gene Name DCK
Actions substrate
References
  • Warnke C, Wiendl H, Hartung HP, Stuve O, Kieseier BC: Identification of targets and new developments in the treatment of multiple sclerosis - focus on cladribine. Drug Des Devel Ther. 2010 Jul 21;4:117-26. - Pubmed
  • Sigal DS, Miller HJ, Schram ED, Saven A: Beyond hairy cell: the activity of cladribine in other hematologic malignancies. Blood. 2010 Jul 15. - Pubmed
  • Kantarjian HM, Jeha S, Gandhi V, Wess M, Faderl S: Clofarabine: past, present, and future. Leuk Lymphoma. 2007 Oct;48(10):1922-30. - Pubmed
  • Sampat K, Kantarjian H, Borthakur G: Clofarabine: emerging role in leukemias. Expert Opin Investig Drugs. 2009 Oct;18(10):1559-64. - Pubmed
  • Zhenchuk A, Lotfi K, Juliusson G, Albertioni F: Mechanisms of anti-cancer action and pharmacology of clofarabine. Biochem Pharmacol. 2009 Dec 1;78(11):1351-9. Epub 2009 Jul 1. - Pubmed
  • Larson ML, Venugopal P: Clofarabine: a new treatment option for patients with acute myeloid leukemia. Expert Opin Pharmacother. 2009 Jun;10(8):1353-7. - Pubmed
DTHybrid score 1.2302

Transporters


Solute carrier family 22 member 2
Name Solute carrier family 22 member 2
Gene Name SLC22A2
Actions substrate
References
  • Chen R, Nelson JA: Role of organic cation transporters in the renal secretion of nucleosides. Biochem Pharmacol. 2000 Jul 15;60(2):215-9. - Pubmed
DTHybrid score 0.4462
Solute carrier family 22 member 1
Name Solute carrier family 22 member 1
Gene Name SLC22A1
Actions substrate
References
  • Chen R, Nelson JA: Role of organic cation transporters in the renal secretion of nucleosides. Biochem Pharmacol. 2000 Jul 15;60(2):215-9. - Pubmed
DTHybrid score 0.5021
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions substrate
References
  • de Wolf C, Jansen R, Yamaguchi H, de Haas M, van de Wetering K, Wijnholds J, Beijnen J, Borst P: Contribution of the drug transporter ABCG2 (breast cancer resistance protein) to resistance against anticancer nucleosides. Mol Cancer Ther. 2008 Sep;7(9):3092-102. Epub 2008 Sep 2. - Pubmed
DTHybrid score 0.4674
Solute carrier family 28 member 3
Name Solute carrier family 28 member 3
Gene Name SLC28A3
Actions Not Available
References
  • Badagnani I, Chan W, Castro RA, Brett CM, Huang CC, Stryke D, Kawamoto M, Johns SJ, Ferrin TE, Carlson EJ, Burchard EG, Giacomini KM: Functional analysis of genetic variants in the human concentrative nucleoside transporter 3 (CNT3; SLC28A3). Pharmacogenomics J. 2005;5(3):157-65. - Pubmed
DTHybrid score 0.8352

Predictions


Id Partner name Gene Name Score
2870 Purine nucleoside phosphorylase punA 1.7907
2945 Purine nucleoside phosphorylase punA 1.7907
4659 Purine nucleoside phosphorylase TM_1596 1.7907
4825 Purine nucleoside phosphorylase TTHA1435 1.7907
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.3119
6083 Deoxyguanosine kinase, mitochondrial DGUOK 0.1744
1588 Multidrug resistance protein 1 ABCB1 0.1352
5142 Protein-tyrosine-phosphatase PPI 0.1295
4119 Cytochrome P450 2D6 CYP2D6 0.1153
6315 V-type proton ATPase subunit B, brain isoform ATP6V1B2 0.1127
1654 Interleukin-1 beta IL1B 0.1049
3957 Adenosine deaminase ADA 0.0993
3690 Class B acid phosphatase precursor aphA 0.0952
566 Serotransferrin TF 0.0922
4512 Cytochrome P450 3A4 CYP3A4 0.0891
798 Osteocalcin BGLAP 0.0862
3611 Cytidine deaminase cdd 0.0859
3707 Cytidine deaminase cdd 0.0859
4211 Cytidine deaminase CDA 0.0859
5421 Uridine phosphorylase, putative PFE0660c 0.0777
702 UMP-CMP kinase CMPK1 0.0755
2257 Uridine phosphorylase udp 0.0736
5132 Uridine phosphorylase udp 0.0736
6148 Multidrug resistance-associated protein 7 ABCC10 0.073
6147 Solute carrier family 22 member 3 SLC22A3 0.0717
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0704
24 Thymidylate synthase TMP1 0.0609
359 Thymidylate synthase TYMS 0.0609
2626 Thymidylate synthase thyA 0.0609
2729 Thymidylate synthase thyA 0.0609
5352 Thymidylate synthase THYA 0.0609
4200 Cytochrome P450 1A2 CYP1A2 0.0595
118 Organic cation/carnitine transporter 2 SLC22A5 0.0558
4757 Cytochrome P450 2C9 CYP2C9 0.0556
4118 Cytochrome P450 3A5 CYP3A5 0.055
6016 Cytochrome P450 2C19 CYP2C19 0.0542
1729 Solute carrier family 22 member 6 SLC22A6 0.0532
6021 Adenosine kinase ADK 0.0531
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0513
6142 Solute carrier family 22 member 8 SLC22A8 0.0491
862 Multidrug resistance-associated protein 1 ABCC1 0.0465
833 Organic cation/carnitine transporter 1 SLC22A4 0.044
6107 Cytochrome P450 3A7 CYP3A7 0.0378
3755 Nucleoside-specific channel-forming protein tsx precursor tsx 0.0357
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0354
4924 Cytochrome P450 2C8 CYP2C8 0.0352
311 RNA-directed RNA polymerase catalytic subunit PB1 0.0349
752 Large structural protein L 0.0349
390 Adenosine A3 receptor ADORA3 0.0339
2164 Multidrug resistance-associated protein 4 ABCC4 0.0329
268 Adenosine A2b receptor ADORA2B 0.0323
1673 GTP cyclohydrolase I GCH1 0.0311
3302 GTP cyclohydrolase I folE 0.0311
509 Thymidine kinase TK 0.0311
570 Thymidine kinase TK 0.0311
2559 Thymidine kinase TK 0.0311
3430 Thymidine kinase tdk 0.0311
3518 Thymidine kinase TK 0.0311
5301 Thymidine kinase tdk 0.0311
5771 Thymidine kinase ORF36 0.0311
7009 Thymidine kinase ORF36 0.0311
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0304
6024 Cytochrome P450 1A1 CYP1A1 0.0304
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0303
587 Serum albumin ALB 0.0295
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0281
776 Bile salt export pump ABCB11 0.0277
2837 Xanthosine phosphorylase xapA 0.0273
508 Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 ENPP1 0.0268
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0265
6143 Solute carrier family 22 member 7 SLC22A7 0.0265
2251 Thymidylate kinase tmk 0.0262
2254 Thymidylate kinase DTYMK 0.0262
3522 Thymidylate kinase tmk 0.0262
3478 Glucose-1-phosphate thymidylyltransferase rmlA 0.0257
4277 Glucose-1-phosphate thymidylyltransferase rmlA 0.0257
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0244
1830 5'-nucleotidase NT5E 0.024
6136 Multidrug resistance-associated protein 5 ABCC5 0.024
3300 Xanthine phosphoribosyltransferase xpt 0.0238
3681 Xanthine phosphoribosyltransferase gpt 0.0238
6030 Cytochrome P450 2B6 CYP2B6 0.0237
766 Beta-2 adrenergic receptor ADRB2 0.0237
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0236
16 Adenosine A1 receptor ADORA1 0.0236
1178 Adenosine A2a receptor ADORA2A 0.0236
125 DNA polymerase beta POLB 0.0227
3947 Xanthine dehydrogenase/oxidase XDH 0.0225
1898 Cytochrome P450 1B1 CYP1B1 0.0214
1043 Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase GART 0.0205
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0205
193 Beta-1 adrenergic receptor ADRB1 0.0203
6013 Cytochrome P450 2E1 CYP2E1 0.0198
556 Alpha-1A adrenergic receptor ADRA1A 0.0187
87 Hypoxanthine-guanine phosphoribosyltransferase HPRT1 0.0187
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0186
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.0183
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.018
1024 Solute carrier family 22 member 11 SLC22A11 0.0178
1405 Thiopurine S-methyltransferase TPMT 0.0178
831 D(2) dopamine receptor DRD2 0.0173
6137 Multidrug resistance-associated protein 6 ABCC6 0.0168
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0166
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0164
6020 Aldehyde oxidase AOX1 0.0162
342 P protein [Includes: DNA-directed DNA polymerase P 0.016
612 P protein [Includes: DNA-directed DNA polymerase P 0.016
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0159
6010 Thiamine transporter 1 SLC19A2 0.0159
341 5-hydroxytryptamine 3 receptor HTR3A 0.0159
378 Alpha-2C adrenergic receptor ADRA2C 0.0158
124 Histamine H2 receptor HRH2 0.0152
3923 Cholinesterase BCHE 0.0148
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0147
632 Alpha-1B adrenergic receptor ADRA1B 0.0146
175 Thiamin pyrophosphokinase 1 TPK1 0.0142
23 D(1A) dopamine receptor DRD1 0.0139
281 5'-AMP-activated protein kinase subunit beta-1 PRKAB1 0.0137
502 5-hydroxytryptamine 2A receptor HTR2A 0.0136
365 Dihydrofolate reductase DHFR 0.0136
2381 Dihydrofolate reductase DFR1 0.0136
2833 Dihydrofolate reductase Not Available 0.0136
2931 Dihydrofolate reductase folA 0.0136
3544 Dihydrofolate reductase folA 0.0136
3682 Dihydrofolate reductase folA 0.0136
6642 Dihydrofolate reductase folA 0.0136
6756 Dihydrofolate reductase dfrA 0.0136
474 Acetylcholinesterase ACHE 0.0136
5718 Cytochrome P450 2A6 CYP2A6 0.0135
1353 DNA topoisomerase 1 TOP1 0.0135
3552 DNA topoisomerase 1 topA 0.0135
844 Epidermal growth factor receptor EGFR 0.0134
629 Alpha-2B adrenergic receptor ADRA2B 0.0134
5626 Nucleoside diphosphate kinase B NME2 0.0132
504 Mast/stem cell growth factor receptor KIT 0.013
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.013
817 DNA topoisomerase 2-alpha TOP2A 0.0128
492 Histamine H1 receptor HRH1 0.0127
672 Prostaglandin F2-alpha receptor PTGFR 0.0125
320 5-hydroxytryptamine 1A receptor HTR1A 0.0125
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0123
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0122
7 Nitric oxide synthase, inducible NOS2 0.0121
318 Alpha-2A adrenergic receptor ADRA2A 0.0119
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0118
789 Alpha-1D adrenergic receptor ADRA1D 0.0116
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0116
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0115
6031 Cytochrome P450 3A43 CYP3A43 0.0115
5294 Nucleoside diphosphate kinase A NME1 0.0113
6106 Cytochrome P450 2C18 CYP2C18 0.0111
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0107
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0104
824 Sodium-dependent serotonin transporter SLC6A4 0.0102
136 Estrogen receptor ESR1 0.01
6141 Sodium/bile acid cotransporter SLC10A1 0.0098
228 Beta platelet-derived growth factor receptor PDGFRB 0.0095
33 Cystine/glutamate transporter SLC7A11 0.0094
908 Glutathione S-transferase theta-1 GSTT1 0.0093
20 Prostaglandin G/H synthase 1 PTGS1 0.0093
713 Sodium-dependent dopamine transporter SLC6A3 0.0093
117 Sterol O-acyltransferase 1 SOAT1 0.009
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.009
6163 Copper-transporting ATPase 2 ATP7B 0.009
6165 Copper-transporting ATPase 1 ATP7A 0.009
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0089
6070 Nischarin NISCH 0.0089
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0086
6146 High affinity copper uptake protein 1 SLC31A1 0.0086
694 Matrix protein 2 M 0.0086
3939 Amine oxidase [flavin-containing] B MAOB 0.0085
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0085
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0085
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0085
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0084
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0084
4203 Histamine N-methyltransferase HNMT 0.0083
756 Sex hormone-binding globulin SHBG 0.0083
731 HIV-1 protease HIV-1 protease 0.0083
738 Monocarboxylate transporter 1 SLC16A1 0.0082
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0081
2472 Voltage-gated potassium channel kcsA 0.0081
6366 Voltage-gated potassium channel kcsA 0.0081
869 Estrogen receptor beta ESR2 0.008
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0077
3704 Spermidine/putrescine-binding periplasmic protein precursor potD 0.0077
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0076
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0076
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0076
904 Glutathione S-transferase P GSTP1 0.0075
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0075
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0074
4120 NADPH--cytochrome P450 reductase POR 0.0074
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0074
131 Synaptic vesicular amine transporter SLC18A2 0.0074
338 DNA polymerase UL30 0.0073
379 DNA polymerase UL54 0.0073
697 DNA polymerase ORF28 0.0073
2482 DNA polymerase 43 0.0073
4104 DNA polymerase BALF5 0.0073
896 Glutathione S-transferase Mu 1 GSTM1 0.0073
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0073
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0072
6599 HTH-type transcriptional regulator ttgR ttgR 0.0071
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0071
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.007
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.007
102 DNA topoisomerase I, mitochondrial TOP1MT 0.007
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0069
828 Phenylalanine-4-hydroxylase PAH 0.0068
3109 Phenylalanine-4-hydroxylase phhA 0.0068
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0068
3560 Gentamicin 3'-acetyltransferase aacC1 0.0067
992 Protein tyrosine kinase 2 beta PTK2B 0.0067
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0067
1757 Myeloperoxidase MPO 0.0066
3941 Amine oxidase [flavin-containing] A MAOA 0.0066
749 Amiloride-sensitive cation channel 1, neuronal ACCN1 0.0066
5126 Arginase rocF 0.0064
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0062
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0062
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
1341 Histamine H3 receptor HRH3 0.006
3811 Cytochrome P450 19A1 CYP19A1 0.006
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.006
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.006
885 5-hydroxytryptamine 1B receptor HTR1B 0.0059
387 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0059
7187 Amiloride-sensitive amine oxidase [copper-containing] ABP1 0.0059
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0058
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0058
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0058
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0058
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0058
827 Sodium/hydrogen exchanger 1 SLC9A1 0.0058
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0058
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0058
164 Histamine H4 receptor HRH4 0.0058
740 Argininosuccinate synthase ASS1 0.0058
865 Argininosuccinate synthase ASS1 0.0058
2680 Argininosuccinate synthase argG 0.0058
3194 Argininosuccinate synthase argG 0.0058
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
477 DNA topoisomerase 4 subunit A parC 0.0056
886 DNA topoisomerase 4 subunit A parC 0.0056
6226 DNA topoisomerase 4 subunit A parC 0.0056
404 DNA gyrase subunit A gyrA 0.0055
6224 DNA gyrase subunit A gyrA 0.0055
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0055
1770 Phospholipase C PLCL1 0.0055
2841 Phospholipase C plc 0.0055
6167 Organic solute transporter subunit beta OSTB 0.0055
468 Cytochrome P450 4A11 CYP4A11 0.0055
6166 Organic solute transporter subunit alpha OSTA 0.0055
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0054
26 Vascular endothelial growth factor receptor 3 FLT4 0.0053
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0053
163 D(1B) dopamine receptor DRD5 0.0052
1517 Beta-3 adrenergic receptor ADRB3 0.0051
887 DNA gyrase subunit B gyrB 0.0051
4150 DNA gyrase subunit B gyrB 0.0051
6225 DNA gyrase subunit B gyrB 0.0051
32 Vascular endothelial growth factor receptor 1 FLT1 0.0051
407 Vascular endothelial growth factor receptor 2 KDR 0.0051
624 Guanidinoacetate N-methyltransferase GAMT 0.005
1650 Heme carrier protein 1 SLC46A1 0.005
432 D(4) dopamine receptor DRD4 0.005
5787 Angiopoietin-1 receptor TEK 0.0049
29 Tubulin beta-1 chain TUBB1 0.0049
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0048
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0048
1618 High affinity nerve growth factor receptor NTRK1 0.0048
638 D(3) dopamine receptor DRD3 0.0048
3810 Catechol O-methyltransferase COMT 0.0047
1864 RET proto-oncogene RET 0.0046
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0046
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0046
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0046
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0046
976 Platelet glycoprotein IX GP9 0.0046
303 Diamine acetyltransferase 2 SAT2 0.0045
623 Spermine oxidase SMOX 0.0045
1317 Spermine synthase SMS 0.0045
2539 Tubulin alpha-1 chain TUBA4A 0.0045
725 5-hydroxytryptamine 1D receptor HTR1D 0.0045
4192 DNA topoisomerase 2-beta TOP2B 0.0044
5682 Ribonuclease pancreatic RNASE1 0.0044
465 Calmodulin CALM1 0.0044
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0043
6014 Cytochrome P450 2A13 CYP2A13 0.0042
4217 Telomerase reverse transcriptase TERT 0.0041
6432 Transporter snf 0.0041
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0041
123 Diamine acetyltransferase 1 SAT1 0.004
165 FL cytokine receptor FLT3 0.004
6220 Aryl hydrocarbon receptor AHR 0.0039
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0039
161 Tubulin beta chain TUBB 0.0037
312 Tubulin beta chain TUB2 0.0037
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0037
527 Prostacyclin receptor PTGIR 0.0036
2300 Lysozyme E 0.0036
3633 Lysozyme R 0.0036
5597 Lysozyme 17 0.0036
723 Cytosolic phospholipase A2 PLA2G4A 0.0036
3929 Phosphoethanolamine/phosphocholine phosphatase PHOSPHO1 0.0036
3926 Choline transporter-like protein 2 SLC44A2 0.0036
3933 Choline/ethanolaminephosphotransferase CEPT1 0.0036
1686 Choline transporter-like protein 1 SLC44A1 0.0036
3927 Choline transporter-like protein 3 SLC44A3 0.0036
861 Choline kinase alpha CHKA 0.0036
549 Choline-phosphate cytidylyltransferase B PCYT1B 0.0036
3925 Choline transporter-like protein 4 SLC44A4 0.0036
264 Choline/ethanolamine kinase [Includes: Choline kinase beta CHKB 0.0036
769 High-affinity choline transporter 1 SLC5A7 0.0036
700 Choline dehydrogenase, mitochondrial CHDH 0.0036
576 Choline O-acetyltransferase CHAT 0.0036
3922 Phospholipase D2 PLD2 0.0036
3924 Phospholipase D1 PLD1 0.0036
1074 Urokinase-type plasminogen activator PLAU 0.0036
6149 Solute carrier family 22 member 10 SLC22A10 0.0034
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0034
290 Prostaglandin G/H synthase 2 PTGS2 0.0034
3917 Methylenetetrahydrofolate reductase MTHFR 0.0034
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0034
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0033
3856 Fibroblast growth factor receptor 3 FGFR3 0.0033
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0032
380 Cytochrome P450 17A1 CYP17A1 0.0032
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0032
2320 Thymidine kinase, cytosolic TK1 0.0032
70 Type-1 angiotensin II receptor AGTR1 0.0032
461 Glycine receptor subunit alpha-3 GLRA3 0.0032
153 Dopamine beta-hydroxylase DBH 0.0031
449 Ornithine decarboxylase ODC1 0.0031
293 Gamma-glutamyl hydrolase GGH 0.0031
6212 Tubulin gamma-1 chain TUBG1 0.0031
6210 Tubulin delta chain TUBD1 0.0031
6211 Tubulin epsilon chain TUBE1 0.0031
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.003
6218 Pannexin-1 PANX1 0.003
5923 Microtubule-associated protein tau MAPT 0.003
5924 Microtubule-associated protein 4 MAP4 0.003
489 Monocarboxylate transporter 2 SLC16A7 0.003
751 Potassium channel subfamily K member 6 KCNK6 0.003
469 Annexin A1 ANXA1 0.003
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0029
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
467 Delta-type opioid receptor OPRD1 0.0029
696 Kappa-type opioid receptor OPRK1 0.0029
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0028
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0028
1360 Sphingomyelin phosphodiesterase SMPD1 0.0028
436 5-hydroxytryptamine 2B receptor HTR2B 0.0028
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0028
1852 Microtubule-associated protein 2 MAP2 0.0028
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0027
4604 Liver carboxylesterase 1 CES1 0.0027
847 Mu-type opioid receptor OPRM1 0.0027
172 Potassium channel subfamily K member 1 KCNK1 0.0027
106 Cannabinoid receptor 2 CNR2 0.0027
373 Transthyretin TTR 0.0027
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0027
6085 Fatty acid-binding protein, intestinal FABP2 0.0026
273 Apoptosis regulator Bcl-2 BCL2 0.0026
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0026
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0026
68 Cannabinoid receptor 1 CNR1 0.0026
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0026
804 Mitochondrial folate transporter/carrier SLC25A32 0.0026
718 Folate receptor gamma FOLR3 0.0026
299 Folate receptor beta FOLR2 0.0026
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0026
936 Ephrin type-A receptor 2 EPHA2 0.0026
3959 Cell division protein kinase 4 CDK4 0.0025
511 5-hydroxytryptamine 1F receptor HTR1F 0.0025
590 5-hydroxytryptamine 2C receptor HTR2C 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0025
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0025
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0025
183 Vascular endothelial growth factor A VEGFA 0.0024
1629 Transcription factor AP-1 JUN 0.0024
1760 Aminopeptidase N ANPEP 0.0024
6843 Aminopeptidase N pepN 0.0024
3955 Cell division protein kinase 6 CDK6 0.0023
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0023
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0023
3587 Gastrotropin FABP6 0.0023
737 Mineralocorticoid receptor NR3C2 0.0022
823 Fibroblast growth factor receptor 2 FGFR2 0.0022
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0022
2449 Tubulin alpha-3 chain TUBA1A 0.0022
6182 Cytochrome P450 2J2 CYP2J2 0.0022
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0021
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0021
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0021
5287 Signaling protein Not Available 0.0021
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0021
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0021
5288 Shikimate kinase aroK 0.0021
5304 UPF0166 protein TM_0021 TM_0021 0.0021
5270 ATP-dependent Clp protease ATP-binding subunit clpX clpX 0.0021
5314 UPF0079 ATP-binding protein HI0065 HI_0065 0.0021
5259 Transcriptional regulator ntrC1 0.0021
6699 Transcriptional regulator Cgl2612 0.0021
5290 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0021
5638 ATP-dependent hsl protease ATP-binding subunit hslU hslU 0.0021
3199 Phosphopantetheine adenylyltransferase coaD 0.0021
3543 Phosphopantetheine adenylyltransferase coaD 0.0021
3567 Phosphopantetheine adenylyltransferase coaD 0.0021
5289 Phosphopantetheine adenylyltransferase coaD 0.0021
2874 Nitrogenase iron protein 1 nifH1 0.0021
4346 Polynucleotide kinase pseT 0.0021
5293 Shikimate kinase 2 aroL 0.0021
5292 Putative partitioning protein TT_C1605 0.0021
5281 Plasmid segregation protein parM parM 0.0021
5305 Phosphoribosylaminoimidazole carboxylase ATPase subunit purK 0.0021
5299 D-alanine--D-alanine ligase ddl 0.0021
6598 D-alanine--D-alanine ligase ddl 0.0021
5276 Chromosomal replication initiator protein dnaA dnaA 0.0021
5266 Activator of hgdC 0.0021
4794 Phosphoenolpyruvate carboxykinase [ATP] pckA 0.0021
5283 D-alanine--D-alanine ligase B ddlB 0.0021
5275 Multidrug resistance ABC transporter ATP-binding and permease protein lmrA 0.0021
5308 Preprotein translocase secA 1 subunit secA1 0.0021
5315 Chaperone protein htpG htpG 0.0021
1549 Heat shock 70 kDa protein 1 HSPA1A 0.0021
5284 Large T antigen Not Available 0.0021
3777 ATP-dependent Clp protease ATP-binding subunit clpA clpA 0.0021
3982 Phosphoribosylformylglycinamidine synthase PFAS 0.0021
5261 Phosphoribosylformylglycinamidine synthase purL 0.0021
5277 Preprotein translocase subunit secA secA 0.0021
5291 Glycogen synthase 1 glgA1 0.0021
5264 DNA replication protein REP 0.0021
5285 Kinesin heavy chain KIF5B 0.0021
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
614 Progesterone receptor PGR 0.002
1058 Cell division protein kinase 5 CDK5 0.002
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0019
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0019
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0019
6837 Serine/threonine-protein kinase 17B STK17B 0.0018
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0018
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0018
871 Glucocorticoid receptor NR3C1 0.0018
3809 Estrogen-related receptor gamma ESRRG 0.0018
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0018
275 Arachidonate 5-lipoxygenase ALOX5 0.0017
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0017
2216 Fibroblast growth factor receptor 4 FGFR4 0.0017
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0017
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0017
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0017
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0017
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0017
6228 Nuclear receptor coactivator 1 NCOA1 0.0017
1063 Signal transducer and activator of transcription 5B STAT5B 0.0017
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0017
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0017
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0017
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0017
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0017
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0017
6241 Nuclear receptor coactivator 2 NCOA2 0.0017
239 Coagulation factor X F10 0.0017
4226 Uridine phosphorylase 2 UPP2 0.0017
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0017
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0017
4106 Guanylate kinase GUK1 0.0016
4516 Guanylate kinase gmk 0.0016
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0016
6277 Heat shock cognate 71 kDa protein HSPA8 0.0016
3390 Aminoglycoside 3'-phosphotransferase aphA 0.0016
6029 Aminoglycoside 3'-phosphotransferase aphA1 0.0016
4837 Cag-alfa cag-alfa 0.0016
5646 Galactokinase GALK1 0.0016
5302 TrwB trwB 0.0016
4839 DNA polymerase III subunit tau dnaX 0.0016
4774 NTPase P4 Not Available 0.0016
4838 PMS1 protein homolog 2 PMS2 0.0016
5265 FtsH ftsH 0.0016
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0016
340 Apoptotic protease-activating factor 1 APAF1 0.0016
4225 Uridine phosphorylase 1 UPP1 0.0016
2270 Dephospho-CoA kinase coaE 0.0016
5189 Trimethylamine dehydrogenase tmd 0.0016
2284 Adenylate kinase adk 0.0016
2296 Adenylate kinase adk 0.0016
2311 Adenylate kinase adk 0.0016
2312 Adenylate kinase Not Available 0.0016
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0016
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0015
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0015
5295 2-keto-3-deoxy-gluconate kinase TT_P0036 0.0015
2751 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0015
4755 Holliday junction ATP-dependent DNA helicase ruvB ruvB 0.0015
3470 Hypothetical protein MG245 homolog MPN_348 0.0015
3175 Glutamate--cysteine ligase gshA 0.0015
3426 Glutamine synthetase glnA 0.0015
3987 Glutamine synthetase GLUL 0.0015
5300 Antigen peptide transporter 1 TAP1 0.0015
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0015
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0015
2683 Mono-ADP-ribosyltransferase C3 C3 0.0015
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0015
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0015
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0015
2390 Nonsecretory ribonuclease RNASE2 0.0014
413 Amidophosphoribosyltransferase PPAT 0.0014
2515 Amidophosphoribosyltransferase purF 0.0014
3714 Amidophosphoribosyltransferase purF 0.0014
5312 Kinesin-like protein KIF1A KIF1A 0.0014
484 Tyrosine-protein kinase ABL2 ABL2 0.0014
2282 Protein recA recA 0.0014
2315 Protein recA recA 0.0014
2332 Protein recA recA 0.0014
5263 Protein recA recA 0.0014
2599 Tyrosine-protein kinase HCK HCK 0.0014
5798 Mitogen-activated protein kinase 11 MAPK11 0.0014
2922 Glycerol kinase glpK 0.0014
408 Riboflavin kinase RFK 0.0014
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0014
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0013
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0013
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0013
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0013
6824 Tyrosine-protein kinase Lyn LYN 0.0013
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0013
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0013
5271 Focal adhesion kinase 1 PTK2 0.0013
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0013
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0013
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
2615 Chemotaxis protein cheA cheA 0.0013
146 Androgen receptor AR 0.0013
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0013
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0013
6832 Serine/threonine-protein kinase SRPK2 SRPK2 0.0013
1881 Hexokinase-1 HK1 0.0013
760 Fibroblast growth factor 1 FGF1 0.0013
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0013
2371 Pantothenate kinase coaA 0.0013
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0013
3669 Ribokinase rbsK 0.0013
2950 Inositol-trisphosphate 3-kinase A ITPKA 0.0012
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0012
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0012
2892 Acetylglutamate kinase argB 0.0012
3550 Acetylglutamate kinase argB 0.0012
4366 Riboflavin kinase/FMN adenylyltransferase TM_0857 0.0012
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0012
825 Arsenical pump-driving ATPase ASNA1 0.0012
3435 Arsenical pump-driving ATPase arsA 0.0012
3639 Thymidine phosphorylase deoA 0.0012
3936 Thymidine phosphorylase TYMP 0.0012
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0012
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0012
2697 Uridine-cytidine kinase 2 UCK2 0.0012
6857 [Pyruvate dehydrogenase [lipoamide]] kinase isozyme 2, mitochondrial PDK2 0.0012
2727 S-adenosylmethionine synthetase metK 0.0012
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0012
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0012
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0012
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0011
788 Creatine kinase M-type CKM 0.0011
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0011
2817 Phosphoribosylglycinamide formyltransferase 2 purT 0.0011
6390 Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 ATP2A1 0.0011
453 S-adenosylmethionine synthetase isoform type-1 MAT1A 0.0011
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0011
48 Pyridoxal kinase PDXK 0.0011
2240 Cell division protein kinase 2 CDK2 0.0011
61 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0011
2644 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0011
2710 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase folK 0.0011
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0011
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0011
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0011
207 Glutathione synthetase GSS 0.001
5269 Glutathione synthetase gshB 0.001
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.001
2334 Dethiobiotin synthetase bioD 0.001
6555 Dethiobiotin synthetase bioD 0.001
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.001
5818 Folate receptor alpha FOLR1 0.001
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.001
2091 Endoplasmin HSP90B1 0.001
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.001
1192 Sulfotransferase 1A1 SULT1A1 0.001
84 Nuclear receptor 0B1 NR0B1 0.001
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.001
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.001
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.001
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.001
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.001
6168 Solute carrier family 22 member 16 SLC22A16 0.001
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.001
2317 UDP-N-acetylmuramoylalanine--D-glutamate ligase murD 0.001
6395 Myosin-14 MYH14 0.0009
1422 Serine/threonine-protein kinase 6 AURKA 0.0009
3379 Kinesin-like protein KIF11 KIF11 0.0009
3456 Heat shock protein HSP 90-beta HSP90AB1 0.0009
3822 Actin, alpha skeletal muscle ACTA1 0.0009
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0008
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0008
1721 Glycogen synthase kinase-3 beta GSK3B 0.0008
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0008
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0008
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0007
76 Nitric-oxide synthase, brain NOS1 0.0007
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0007
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0007
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0006
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0006
291 Nitric-oxide synthase, endothelial NOS3 0.0006
↑