DT-Web

DB00974 - Edetic Acid


Identification
Name Edetic Acid
Accession Number DB00974 (APRD01327)
Type small molecule
Description A chelating agent (chelating agents) that sequesters a variety of polyvalent cations. It is used in pharmaceutical manufacturing and as a food additive. [PubChem]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 292.2426
Groups approved
Monoisotopic Weight 292.090665498
Pharmacology
Indication For the reduction of blood levels and depot stores of lead in lead poisoning (acute and chronic) and lead encephalopathy, in both pediatric populations and adults.
Mechanism of action The pharmacologic effects of edetate calcium disodium are due to the formation of chelates with divalent and trivalent metals. A stable chelate will form with any metal that has the ability to displace calcium from the molecule, a feature shared by lead, zinc, cadmium, manganese, iron and mercury. The amounts of manganese and iron metabolized are not significant. Copper is not mobilized and mercury is unavailable for chelation because it is too tightly bound to body ligands or it is stored in inaccessible body compartments. The excretion of calcium by the body is not increased following intravenous administration of edetate calcium disodium, but the excretion of zinc is considerably increased.
Absorption Poorly absorbed from the gastrointestinal tract. Well absorbed following intramuscular injection.
Protein binding Not Available
Biotransformation Almost none of the compound is metabolized.
Route of elimination It is excreted primarily by the kidney, with about 50% excreted in one hour and over 95% within 24 hours.2 Almost none of the compound is metabolized.
Toxicity Inadvertent administration of 5 times the recommended dose, infused intravenously over a 24 hour period, to an asymptomatic 16 month old patient with a blood lead content of 56 mcg/dl did not cause any ill effects. Edetate calcium disodium can aggravate the symptoms of severe lead poisoning, therefore, most toxic effects (cerebral edema, renal tubular necrosis) appear to be associated with lead poisoning. Because of cerebral edema, a therapeutic dose may be lethal to an adult or a pediatric patient with lead encephalopathy. Higher dosage of edetate calcium disodium may produce a more severe zinc deficiency.
Affected organisms
  • Humans and other mammals
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Lead
Name Lead
Gene Name Not Available
Pharmacological action yes
Actions chelator
References
  • Onnby L, Giorgi C, Plieva FM, Mattiasson B: Removal of heavy metals from water effluents using supermacroporous metal chelating cryogels. Biotechnol Prog. 2010 Sep;26(5):1295-302. - Pubmed
  • Chakraborty N, Banerjee A, Pal R: Accumulation of lead by free and immobilized cyanobacteria with special reference to accumulation factor and recovery. Bioresour Technol. 2010 Dec 13. - Pubmed
  • Tian SK, Lu LL, Yang XE, Huang HG, Brown P, Labavitch J, Liao HB, He ZL: The impact of EDTA on lead distribution and speciation in the accumulator Sedum alfredii by synchrotron X-ray investigation. Environ Pollut. 2010 Dec 17. - Pubmed
DTHybrid score Not Available
Iron
Name Iron
Gene Name Not Available
Pharmacological action unknown
Actions chelator
References
  • Hasegawa H, Rahman IM, Kinoshita S, Maki T, Furusho Y: Separation of dissolved iron from the aqueous system with excess ligand. Chemosphere. 2011 Jan 3. - Pubmed
DTHybrid score Not Available
manganese
Name manganese
Gene Name Not Available
Pharmacological action unknown
Actions chelator
References
  • Broncel M, Wagner SC, Paul K, Hackenberger CP, Koksch B: Towards understanding secondary structure transitions: phosphorylation and metal coordination in model peptides. Org Biomol Chem. 2010 Jun 7;8(11):2575-9. Epub 2010 Mar 29. - Pubmed
DTHybrid score Not Available

Enzymes


Adenosine deaminase
Name Adenosine deaminase
Gene Name ADA
Actions inhibitor
References
  • Abu-Shady MR, Elshafei AM, el-Beih FM, Mohamed LA: Properties of adenosine deaminase in extracts of Asperigillus terricola. Acta Microbiol Pol. 1994;43(3-4):305-11. - Pubmed
DTHybrid score 1.4094
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions inhibitor
References
  • Bournique B, Petry M, Gousset G: Usefulness of statistic experimental designs in enzymology: example with recombinant hCYP3A4 and 1A2. Anal Biochem. 1999 Dec 1;276(1):18-26. - Pubmed
DTHybrid score 0.2902
Serum paraoxonase/lactonase 3
Name Serum paraoxonase/lactonase 3
Gene Name PON3
Actions inhibitor
References
  • Pla A, Rodrigo L, Hernandez AF, Gil F, Lopez O: Effect of metal ions and calcium on purified PON1 and PON3 from rat liver. Chem Biol Interact. 2007 Apr 5;167(1):63-70. Epub 2007 Jan 16. - Pubmed
DTHybrid score 0.2877
Cytochrome P450 19A1
Name Cytochrome P450 19A1
Gene Name CYP19A1
Actions substrate
References
  • Moslemi S, Vibet A, Papadopoulos V, Camoin L, Silberzahn P, Gaillard JL: Purification and characterization of equine testicular cytochrome P-450 aromatase: comparison with the human enzyme. Comp Biochem Physiol B Biochem Mol Biol. 1997 Sep;118(1):217-27. - Pubmed
  • Bellino FL, Holben L: Placental estrogen synthetase (aromatase): evidence for phosphatase-dependent inactivation. Biochem Biophys Res Commun. 1989 Jul 14;162(1):498-504. - Pubmed
  • Zhang F, Zhou D, Kao YC, Ye J, Chen S: Expression and purification of a recombinant form of human aromatase from Escherichia coli. Biochem Pharmacol. 2002 Nov 1;64(9):1317-24. - Pubmed
  • Milczarek R, Sokolowska E, Hallmann A, Kaletha K, Klimek J: NADPH- and iron-dependent lipid peroxidation inhibit aromatase activity in human placental microsomes. J Steroid Biochem Mol Biol. 2008 Jun;110(3-5):230-5. Epub 2008 Apr 20. - Pubmed
DTHybrid score 0.4082

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.1351
4757 Cytochrome P450 2C9 CYP2C9 0.0768
6016 Cytochrome P450 2C19 CYP2C19 0.0726
4119 Cytochrome P450 2D6 CYP2D6 0.0698
1588 Multidrug resistance protein 1 ABCB1 0.0643
146 Androgen receptor AR 0.0626
4924 Cytochrome P450 2C8 CYP2C8 0.0551
6013 Cytochrome P450 2E1 CYP2E1 0.0512
6024 Cytochrome P450 1A1 CYP1A1 0.0476
4118 Cytochrome P450 3A5 CYP3A5 0.0449
6030 Cytochrome P450 2B6 CYP2B6 0.0432
6107 Cytochrome P450 3A7 CYP3A7 0.0407
338 DNA polymerase UL30 0.0376
379 DNA polymerase UL54 0.0376
697 DNA polymerase ORF28 0.0376
2482 DNA polymerase 43 0.0376
4104 DNA polymerase BALF5 0.0376
136 Estrogen receptor ESR1 0.0368
5718 Cytochrome P450 2A6 CYP2A6 0.0343
4122 Histone deacetylase 2 HDAC2 0.0328
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0289
756 Sex hormone-binding globulin SHBG 0.0287
509 Thymidine kinase TK 0.0282
570 Thymidine kinase TK 0.0282
2559 Thymidine kinase TK 0.0282
3430 Thymidine kinase tdk 0.0282
3518 Thymidine kinase TK 0.0282
5301 Thymidine kinase tdk 0.0282
5771 Thymidine kinase ORF36 0.0282
7009 Thymidine kinase ORF36 0.0282
6083 Deoxyguanosine kinase, mitochondrial DGUOK 0.0278
572 Integrin alpha-L ITGAL 0.0262
36 Insulin receptor INSR 0.0258
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0254
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0251
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0247
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0244
260 Cytochrome P450 51 ERG11 0.0235
761 Cytochrome P450 51 ERG11 0.0235
3163 Cytochrome P450 51 cyp51 0.0235
1178 Adenosine A2a receptor ADORA2A 0.0235
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0235
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0219
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0219
563 Thyroid peroxidase TPO 0.0218
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0214
603 DNA polymerase alpha catalytic subunit POLA1 0.0209
4116 Dihydropteroate synthetase Not Available 0.0199
16 Adenosine A1 receptor ADORA1 0.0197
226 Gonadotropin-releasing hormone receptor GNRHR 0.0193
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0192
3941 Amine oxidase [flavin-containing] A MAOA 0.0184
268 Adenosine A2b receptor ADORA2B 0.0182
1898 Cytochrome P450 1B1 CYP1B1 0.0177
148 Lutropin-choriogonadotropic hormone receptor LHCGR 0.0175
4773 Deoxycytidine kinase DCK 0.0165
587 Serum albumin ALB 0.0162
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0155
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0153
20 Prostaglandin G/H synthase 1 PTGS1 0.0153
390 Adenosine A3 receptor ADORA3 0.0146
3939 Amine oxidase [flavin-containing] B MAOB 0.0137
290 Prostaglandin G/H synthase 2 PTGS2 0.0131
477 DNA topoisomerase 4 subunit A parC 0.0127
886 DNA topoisomerase 4 subunit A parC 0.0127
6226 DNA topoisomerase 4 subunit A parC 0.0127
404 DNA gyrase subunit A gyrA 0.0125
6224 DNA gyrase subunit A gyrA 0.0125
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0119
6021 Adenosine kinase ADK 0.0117
318 Alpha-2A adrenergic receptor ADRA2A 0.0116
3923 Cholinesterase BCHE 0.0116
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0113
2164 Multidrug resistance-associated protein 4 ABCC4 0.011
629 Alpha-2B adrenergic receptor ADRA2B 0.0109
492 Histamine H1 receptor HRH1 0.0108
6171 Solute carrier family 28 member 3 SLC28A3 0.0107
502 5-hydroxytryptamine 2A receptor HTR2A 0.0107
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0106
6136 Multidrug resistance-associated protein 5 ABCC5 0.0104
6145 Solute carrier family 22 member 1 SLC22A1 0.0103
871 Glucocorticoid receptor NR3C1 0.0101
831 D(2) dopamine receptor DRD2 0.01
869 Estrogen receptor beta ESR2 0.01
614 Progesterone receptor PGR 0.0099
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
817 DNA topoisomerase 2-alpha TOP2A 0.0096
6106 Cytochrome P450 2C18 CYP2C18 0.0095
6142 Solute carrier family 22 member 8 SLC22A8 0.0093
556 Alpha-1A adrenergic receptor ADRA1A 0.009
885 5-hydroxytryptamine 1B receptor HTR1B 0.009
23 D(1A) dopamine receptor DRD1 0.0089
6143 Solute carrier family 22 member 7 SLC22A7 0.0089
1729 Solute carrier family 22 member 6 SLC22A6 0.0087
1656 CYP2B protein CYP2B 0.0085
3947 Xanthine dehydrogenase/oxidase XDH 0.0084
380 Cytochrome P450 17A1 CYP17A1 0.0083
824 Sodium-dependent serotonin transporter SLC6A4 0.0082
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0081
590 5-hydroxytryptamine 2C receptor HTR2C 0.0079
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0078
571 Melatonin receptor type 1A MTNR1A 0.0078
1680 Solute carrier family 2, facilitated glucose transporter member 1 SLC2A1 0.0078
362 Melatonin receptor type 1B MTNR1B 0.0078
725 5-hydroxytryptamine 1D receptor HTR1D 0.0077
776 Bile salt export pump ABCB11 0.0075
6144 Solute carrier family 22 member 2 SLC22A2 0.0075
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0071
118 Organic cation/carnitine transporter 2 SLC22A5 0.007
847 Mu-type opioid receptor OPRM1 0.007
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0069
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0069
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0068
862 Multidrug resistance-associated protein 1 ABCC1 0.0068
6020 Aldehyde oxidase AOX1 0.0067
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0067
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0065
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0064
193 Beta-1 adrenergic receptor ADRB1 0.0063
320 5-hydroxytryptamine 1A receptor HTR1A 0.0063
465 Calmodulin CALM1 0.0062
1649 Small inducible cytokine A2 CCL2 0.0062
1010 Cytochrome P450 51A1 CYP51A1 0.0062
632 Alpha-1B adrenergic receptor ADRA1B 0.0062
198 Sodium channel protein type 10 subunit alpha SCN10A 0.006
341 5-hydroxytryptamine 3 receptor HTR3A 0.006
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0058
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0057
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0057
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0056
273 Apoptosis regulator Bcl-2 BCL2 0.0056
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0055
634 Squalene monooxygenase SQLE 0.0053
7196 Squalene monooxygenase ERG1 0.0053
780 Retinoic acid receptor RXR-gamma RXRG 0.0052
229 Retinoic acid receptor beta RARB 0.0052
638 D(3) dopamine receptor DRD3 0.0052
5934 Cytochrome P450 26A1 CYP26A1 0.0052
1757 Myeloperoxidase MPO 0.0052
713 Sodium-dependent dopamine transporter SLC6A3 0.0052
730 Retinoic acid receptor alpha RARA 0.0051
6014 Cytochrome P450 2A13 CYP2A13 0.0051
789 Alpha-1D adrenergic receptor ADRA1D 0.0051
833 Organic cation/carnitine transporter 1 SLC22A4 0.005
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.005
378 Alpha-2C adrenergic receptor ADRA2C 0.005
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.005
144 Hemoglobin subunit alpha HBA1 0.0049
474 Acetylcholinesterase ACHE 0.0049
3809 Estrogen-related receptor gamma ESRRG 0.0048
459 Retinoic acid receptor RXR-alpha RXRA 0.0048
88 Retinoic acid receptor RXR-beta RXRB 0.0048
162 Retinoic acid receptor gamma-1 RARG 0.0047
766 Beta-2 adrenergic receptor ADRB2 0.0047
468 Cytochrome P450 4A11 CYP4A11 0.0046
6220 Aryl hydrocarbon receptor AHR 0.0045
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0045
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0044
777 Tumor necrosis factor TNF 0.0044
6147 Solute carrier family 22 member 3 SLC22A3 0.0043
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0043
714 Glutathione reductase, mitochondrial GSR 0.0042
3830 Calreticulin CALR 0.0042
6031 Cytochrome P450 3A43 CYP3A43 0.0042
844 Epidermal growth factor receptor EGFR 0.0041
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0041
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.004
103 Muscarinic acetylcholine receptor M1 CHRM1 0.004
432 D(4) dopamine receptor DRD4 0.004
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.004
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.004
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0039
6035 Nuclear receptor ROR-beta RORB 0.0039
6034 Hydroxyindole O-methyltransferase ASMT 0.0039
6036 Eosinophil peroxidase EPX 0.0039
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0039
6148 Multidrug resistance-associated protein 7 ABCC10 0.0039
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0038
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0038
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0037
373 Transthyretin TTR 0.0037
2782 Complement C1s subcomponent C1S 0.0037
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0037
511 5-hydroxytryptamine 1F receptor HTR1F 0.0037
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0035
5998 Toll-like receptor 8 TLR8 0.0035
3815 Complement C1q subcomponent subunit A C1QA 0.0034
3816 Complement C1q subcomponent subunit B C1QB 0.0034
3817 Complement C1q subcomponent subunit C C1QC 0.0034
765 Indoleamine 2,3-dioxygenase IDO1 0.0034
565 Extracellular calcium-sensing receptor CASR 0.0034
3818 Low affinity immunoglobulin gamma Fc region receptor III-A FCGR3A 0.0034
712 Tubulin alpha chain TUB1 0.0034
161 Tubulin beta chain TUBB 0.0034
312 Tubulin beta chain TUB2 0.0034
3819 Low affinity immunoglobulin gamma Fc region receptor II-a FCGR2A 0.0034
1102 Low affinity immunoglobulin gamma Fc region receptor III-B FCGR3B 0.0034
3821 Low affinity immunoglobulin gamma Fc region receptor II-c FCGR2C 0.0034
3814 Complement C1r subcomponent C1R 0.0034
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0034
3820 Low affinity immunoglobulin gamma Fc region receptor II-b FCGR2B 0.0034
3810 Catechol O-methyltransferase COMT 0.0033
613 Atrial natriuretic peptide receptor A NPR1 0.0033
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0032
784 High affinity immunoglobulin gamma Fc receptor I FCGR1A 0.0032
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0031
818 50S ribosomal protein L10 rplJ 0.003
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.003
259 Microsomal triglyceride transfer protein large subunit MTTP 0.003
173 Toll-like receptor 7 TLR7 0.003
117 Sterol O-acyltransferase 1 SOAT1 0.003
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0029
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0029
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0029
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0029
467 Delta-type opioid receptor OPRD1 0.0029
992 Protein tyrosine kinase 2 beta PTK2B 0.0028
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0028
163 D(1B) dopamine receptor DRD5 0.0028
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0028
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0028
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.0028
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0028
436 5-hydroxytryptamine 2B receptor HTR2B 0.0028
1192 Sulfotransferase 1A1 SULT1A1 0.0028
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0027
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0027
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0027
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0027
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0027
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0026
6167 Organic solute transporter subunit beta OSTB 0.0026
6166 Organic solute transporter subunit alpha OSTA 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
94 5-hydroxytryptamine 4 receptor HTR4 0.0025
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0025
5880 Thrombopoietin receptor MPL 0.0025
7 Nitric oxide synthase, inducible NOS2 0.0025
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0025
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0024
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0024
1517 Beta-3 adrenergic receptor ADRB3 0.0024
5923 Microtubule-associated protein tau MAPT 0.0024
5924 Microtubule-associated protein 4 MAP4 0.0024
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0024
1024 Solute carrier family 22 member 11 SLC22A11 0.0024
6070 Nischarin NISCH 0.0024
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
267 Plasminogen activator inhibitor 1 SERPINE1 0.0023
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0023
1852 Microtubule-associated protein 2 MAP2 0.0023
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0023
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0023
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0023
4604 Liver carboxylesterase 1 CES1 0.0023
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0022
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0022
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0022
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0022
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0022
26 Vascular endothelial growth factor receptor 3 FLT4 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
731 HIV-1 protease HIV-1 protease 0.0021
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0021
6221 Steroid hormone receptor ERR1 ESRRA 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.0021
32 Vascular endothelial growth factor receptor 1 FLT1 0.0021
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.002
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.002
1820 Beta-nerve growth factor NGF 0.002
4228 Keratin, type II cytoskeletal 7 KRT7 0.002
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.002
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.002
228 Beta platelet-derived growth factor receptor PDGFRB 0.0019
29 Tubulin beta-1 chain TUBB1 0.0019
6141 Sodium/bile acid cotransporter SLC10A1 0.0019
716 5-hydroxytryptamine 7 receptor HTR7 0.0019
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0019
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0019
124 Histamine H2 receptor HRH2 0.0019
84 Nuclear receptor 0B1 NR0B1 0.0019
284 DNA-directed RNA polymerase beta chain rpoB 0.0019
5773 DNA-directed RNA polymerase beta chain rpoB 0.0019
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
122 P2Y purinoceptor 12 P2RY12 0.0018
33 Cystine/glutamate transporter SLC7A11 0.0018
469 Annexin A1 ANXA1 0.0018
6766 O-GlcNAcase BT_4395 BT_4395 0.0018
504 Mast/stem cell growth factor receptor KIT 0.0018
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0018
1256 5-hydroxytryptamine 6 receptor HTR6 0.0017
1648 Elastin ELN 0.0017
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0017
275 Arachidonate 5-lipoxygenase ALOX5 0.0017
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0017
407 Vascular endothelial growth factor receptor 2 KDR 0.0017
1830 5'-nucleotidase NT5E 0.0016
1243 Cathepsin D CTSD 0.0016
427 Substance-P receptor TACR1 0.0016
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0016
921 Glutamate receptor 2 GRIA2 0.0015
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0015
70 Type-1 angiotensin II receptor AGTR1 0.0015
2499 Tubulin beta-2C chain TUBB2C 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
6432 Transporter snf 0.0015
6102 Arylamine N-acetyltransferase 2 NAT2 0.0014
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0014
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0014
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0014
2091 Endoplasmin HSP90B1 0.0014
6859 Protein S100-A4 S100A4 0.0014
904 Glutathione S-transferase P GSTP1 0.0014
2449 Tubulin alpha-3 chain TUBA1A 0.0014
291 Nitric-oxide synthase, endothelial NOS3 0.0013
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0013
543 Penicillin-binding protein 1B mrcB 0.0013
6186 Penicillin-binding protein 1B ponB 0.0013
6822 Penicillin-binding protein 1b pbp1b 0.0013
6844 Penicillin-binding protein 1b pbp1b 0.0013
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0013
645 Penicillin-binding protein 1A mrcA 0.0013
5805 Penicillin-binding protein 1A ponA 0.0013
6185 Penicillin-binding protein 1A mrcA 0.0013
6799 Penicillin-binding protein 1A pbpA 0.0013
159 Penicillin-binding protein 2B penA 0.0013
6121 Penicillin-binding protein 2B penA 0.0013
696 Kappa-type opioid receptor OPRK1 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
6146 High affinity copper uptake protein 1 SLC31A1 0.0012
4311 tRNA TRDMT1 0.0012
4325 tRNA trmD 0.0012
4328 tRNA trmD 0.0012
518 Peroxidase/catalase T katG 0.0012
1629 Transcription factor AP-1 JUN 0.0012
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0012
482 Glycine receptor subunit alpha-1 GLRA1 0.0011
828 Phenylalanine-4-hydroxylase PAH 0.0011
3109 Phenylalanine-4-hydroxylase phhA 0.0011
4238 50S ribosomal protein L4 rplD 0.0011
5578 50S ribosomal protein L4 rplD 0.0011
6173 50S ribosomal protein L4 rplD 0.0011
6219 50S ribosomal protein L4 rplD 0.0011
6043 Putative G-protein coupled receptor 44 GPR44 0.0011
4192 DNA topoisomerase 2-beta TOP2B 0.0011
950 Alpha platelet-derived growth factor receptor PDGFRA 0.001
239 Coagulation factor X F10 0.001
4237 50S ribosomal protein L22 rplV 0.001
1714 Mitogen-activated protein kinase 3 MAPK3 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
908 Glutathione S-transferase theta-1 GSTT1 0.001
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.001
859 Cellular retinoic acid-binding protein 2 CRABP2 0.001
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.001
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.001
823 Fibroblast growth factor receptor 2 FGFR2 0.001
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
6137 Multidrug resistance-associated protein 6 ABCC6 0.0009
6182 Cytochrome P450 2J2 CYP2J2 0.0009
3917 Methylenetetrahydrofolate reductase MTHFR 0.0009
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0009
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0009
365 Dihydrofolate reductase DHFR 0.0009
2381 Dihydrofolate reductase DFR1 0.0009
2833 Dihydrofolate reductase Not Available 0.0009
2931 Dihydrofolate reductase folA 0.0009
3544 Dihydrofolate reductase folA 0.0009
3682 Dihydrofolate reductase folA 0.0009
6642 Dihydrofolate reductase folA 0.0009
6756 Dihydrofolate reductase dfrA 0.0009
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0009
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0009
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0009
528 5-hydroxytryptamine 1E receptor HTR1E 0.0008
2236 Casein kinase II subunit alpha CSNK2A1 0.0008
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0008
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0008
1618 High affinity nerve growth factor receptor NTRK1 0.0008
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0008
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0008
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0008
811 Translocator protein TSPO 0.0008
3856 Fibroblast growth factor receptor 3 FGFR3 0.0008
976 Platelet glycoprotein IX GP9 0.0008
1374 Natriuretic peptides B NPPB 0.0008
1827 Gap junction alpha-1 protein GJA1 0.0008
1908 Vascular cell adhesion protein 1 VCAM1 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
4103 Proteasome subunit beta type 2 PSMB2 0.0007
4102 Proteasome subunit beta type 5 PSMB5 0.0007
4101 Proteasome subunit beta type 1 PSMB1 0.0007
1063 Signal transducer and activator of transcription 5B STAT5B 0.0007
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0007
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0007
814 Ryanodine receptor 1 RYR1 0.0007
822 Aldose reductase AKR1B1 0.0007
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0007
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0007
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0007
251 Alcohol dehydrogenase 1A ADH1A 0.0007
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0007
4225 Uridine phosphorylase 1 UPP1 0.0007
705 Glutamate receptor 1 GRIA1 0.0007
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0007
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0006
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0006
820 Glycine receptor subunit alpha-2 GLRA2 0.0006
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
537 ATP synthase delta chain, mitochondrial ATP5D 0.0006
936 Ephrin type-A receptor 2 EPHA2 0.0006
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0006
484 Tyrosine-protein kinase ABL2 ABL2 0.0006
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0006
444 Alcohol dehydrogenase 1B ADH1B 0.0006
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0006
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0006
183 Vascular endothelial growth factor A VEGFA 0.0006
6163 Copper-transporting ATPase 2 ATP7B 0.0006
6165 Copper-transporting ATPase 1 ATP7A 0.0006
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
1864 RET proto-oncogene RET 0.0006
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0006
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0006
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0006
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0006
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0006
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0006
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0006
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0006
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0006
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0006
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0006
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0005
1275 Estrogen sulfotransferase SULT1E1 0.0005
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0005
153 Dopamine beta-hydroxylase DBH 0.0005
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0005
3639 Thymidine phosphorylase deoA 0.0005
3936 Thymidine phosphorylase TYMP 0.0005
760 Fibroblast growth factor 1 FGF1 0.0005
517 Alcohol dehydrogenase 1C ADH1C 0.0005
798 Osteocalcin BGLAP 0.0005
1050 Bile salt sulfotransferase SULT2A1 0.0005
751 Potassium channel subfamily K member 6 KCNK6 0.0005
1039 Histone deacetylase 9 HDAC9 0.0005
4120 NADPH--cytochrome P450 reductase POR 0.0005
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0005
1360 Sphingomyelin phosphodiesterase SMPD1 0.0005
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0005
369 Coagulation factor VII F7 0.0005
896 Glutathione S-transferase Mu 1 GSTM1 0.0005
3937 Fatty-acid amide hydrolase FAAH 0.0005
172 Potassium channel subfamily K member 1 KCNK1 0.0005
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0004
6149 Solute carrier family 22 member 10 SLC22A10 0.0004
165 FL cytokine receptor FLT3 0.0004
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0004
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0004
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0004
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0004
24 Thymidylate synthase TMP1 0.0004
359 Thymidylate synthase TYMS 0.0004
2626 Thymidylate synthase thyA 0.0004
2729 Thymidylate synthase thyA 0.0004
5352 Thymidylate synthase THYA 0.0004
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0004
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0004
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0004
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0004
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0004
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0004
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0004
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0004
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0004
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0004
737 Mineralocorticoid receptor NR3C2 0.0004
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0004
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0004
295 Carbonic anhydrase 1 CA1 0.0004
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0004
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0003
6085 Fatty acid-binding protein, intestinal FABP2 0.0003
2981 Phospholipase A2, membrane associated PLA2G2A 0.0003
164 Histamine H4 receptor HRH4 0.0003
54 Prothrombin F2 0.0003
738 Monocarboxylate transporter 1 SLC16A1 0.0003
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0003
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0002
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0002
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