DT-Web

DB01645 - Genistein


Identification
Name Genistein
Accession Number DB01645 (EXPT01582)
Type small molecule
Description An isoflavonoid derived from soy products. It inhibits protein-tyrosine kinase and topoisomerase-II (DNA topoisomerases, type II) activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce G2 phase arrest in human and murine cell lines. Additionally, genistein has antihelmintic activity. It has been determined to be the active ingredient in Felmingia vestita, which is a plant traditionally used against worms. It has also been demonstrated to be effective against intestinal parasites such as the common liver fluke, pork trematode and poultry cestode. [Wikipedia] Further, genistein is a phytoestrogen which has selective estrogen receptor modulator properties. It has been investigated in clinical trials as an alternative to classical hormone therapy to help prevent cardiovascular disease in postmenopausal women. [1] Genistein can be found in food sources such as tofu, fava beans, soybeans, kudzu, and lupin. It is also present in certain cell cultures and medicinal plants. [Wikipedia]
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 270.2369
Groups Not Available
Monoisotopic Weight 270.05282343
Pharmacology
Indication Currently Genistein is being studied in clinical trials as a treatment for prostate cancer.
Mechanism of action Genistein may inhibit cancer cell growth by blocking enzymes required for cell growth. Genistein may decrease cardiovascular risk in postmenopausal women by interacting with the nuclear estrogen receptors to alter the transcription of cell specific genes. In randomized clinical trials, genistein was seen to increase the ratio of nitric oxide to endothelin and improved flow-mediated endothelium dependent vasodilation in healthy postmenopausal women. [1] In addition, genistein may have beneficial effects on glucose metabolism by inhibiting islet tyrosine kinase activity as well as insulin release dependent on glucose and sulfonylurea. [1]
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Humans and other mammals
  • Helminthic Microorganisms
  • Parasitic nematodes and other roundworms
Interactions
Drug Interactions Not Available
Food Interactions Not Available

Targets


Estrogen receptor beta
Name Estrogen receptor beta
Gene Name ESR2
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.2944
DNA topoisomerase 2-alpha
Name DNA topoisomerase 2-alpha
Gene Name TOP2A
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.4432
Protein tyrosine kinase 2 beta
Name Protein tyrosine kinase 2 beta
Gene Name PTK2B
Pharmacological action unknown
Actions Not Available
References
  • Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. - Pubmed
  • Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. - Pubmed
DTHybrid score 0.7219
Nuclear receptor coactivator 1
Name Nuclear receptor coactivator 1
Gene Name NCOA1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.0845
Estrogen receptor
Name Estrogen receptor
Gene Name ESR1
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.2875
Nuclear receptor coactivator 2
Name Nuclear receptor coactivator 2
Gene Name NCOA2
Pharmacological action unknown
Actions Not Available
References
  • Berman HM, Westbrook J, Feng Z, Gilliland G, Bhat TN, Weissig H, Shindyalov IN, Bourne PE: The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42. - Pubmed
DTHybrid score 1.1525

Enzymes


Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate
References
  • Hu M, Krausz K, Chen J, Ge X, Li J, Gelboin HL, Gonzalez FJ: Identification of CYP1A2 as the main isoform for the phase I hydroxylated metabolism of genistein and a prodrug converting enzyme of methylated isoflavones. Drug Metab Dispos. 2003 Jul;31(7):924-31. - Pubmed
DTHybrid score 0.3799

Transporters


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions inhibitor
References
  • Castro AF, Altenberg GA: Inhibition of drug transport by genistein in multidrug-resistant cells expressing P-glycoprotein. Biochem Pharmacol. 1997 Jan 10;53(1):89-93. - Pubmed
  • Versantvoort CH, Rhodes T, Twentyman PR: Acceleration of MRP-associated efflux of rhodamine 123 by genistein and related compounds. Br J Cancer. 1996 Dec;74(12):1949-54. - Pubmed
  • Nagy H, Goda K, Fenyvesi F, Bacso Z, Szilasi M, Kappelmayer J, Lustyik G, Cianfriglia M, Szabo G Jr: Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochem Biophys Res Commun. 2004 Mar 19;315(4):942-9. - Pubmed
DTHybrid score 0.4236
Multidrug resistance-associated protein 1
Name Multidrug resistance-associated protein 1
Gene Name ABCC1
Actions inhibitor
References
  • Pec MK, Aguirre A, Fernandez JJ, Souto ML, Dorta JF, Villar J: Dehydrothyrsiferol does not modulate multidrug resistance-associated protein 1 resistance: a functional screening system for MRP1 substrates. Int J Mol Med. 2002 Nov;10(5):605-8. - Pubmed
  • Nguyen H, Zhang S, Morris ME: Effect of flavonoids on MRP1-mediated transport in Panc-1 cells. J Pharm Sci. 2003 Feb;92(2):250-7. - Pubmed
  • Hong J, Lambert JD, Lee SH, Sinko PJ, Yang CS: Involvement of multidrug resistance-associated proteins in regulating cellular levels of (-)-epigallocatechin-3-gallate and its methyl metabolites. Biochem Biophys Res Commun. 2003 Oct 10;310(1):222-7. - Pubmed
  • Versantvoort CH, Rhodes T, Twentyman PR: Acceleration of MRP-associated efflux of rhodamine 123 by genistein and related compounds. Br J Cancer. 1996 Dec;74(12):1949-54. - Pubmed
DTHybrid score 0.2652
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions inhibitor
References
  • Imai Y, Tsukahara S, Asada S, Sugimoto Y: Phytoestrogens/flavonoids reverse breast cancer resistance protein/ABCG2-mediated multidrug resistance. Cancer Res. 2004 Jun 15;64(12):4346-52. - Pubmed
  • Zhang S, Yang X, Morris ME: Flavonoids are inhibitors of breast cancer resistance protein (ABCG2)-mediated transport. Mol Pharmacol. 2004 May;65(5):1208-16. - Pubmed
  • Perez M, Real R, Mendoza G, Merino G, Prieto JG, Alvarez AI: Milk secretion of nitrofurantoin, as a specific BCRP/ABCG2 substrate, in assaf sheep: modulation by isoflavones. J Vet Pharmacol Ther. 2009 Oct;32(5):498-502. - Pubmed
DTHybrid score 0.3256

Carriers


Multidrug resistance protein 1
Name Multidrug resistance protein 1
Gene Name ABCB1
Actions
References Not Available
DTHybrid score 0.4236
Multidrug resistance-associated protein 1
Name Multidrug resistance-associated protein 1
Gene Name ABCC1
Actions
References Not Available
DTHybrid score 0.2652
ATP-binding cassette sub-family G member 2
Name ATP-binding cassette sub-family G member 2
Gene Name ABCG2
Actions
References Not Available
DTHybrid score 0.3256

Predictions


Id Partner name Gene Name Score
4512 Cytochrome P450 3A4 CYP3A4 0.2923
4757 Cytochrome P450 2C9 CYP2C9 0.1855
477 DNA topoisomerase 4 subunit A parC 0.1581
886 DNA topoisomerase 4 subunit A parC 0.1581
6226 DNA topoisomerase 4 subunit A parC 0.1581
404 DNA gyrase subunit A gyrA 0.1553
6224 DNA gyrase subunit A gyrA 0.1553
4119 Cytochrome P450 2D6 CYP2D6 0.1403
6016 Cytochrome P450 2C19 CYP2C19 0.1304
4118 Cytochrome P450 3A5 CYP3A5 0.1249
4924 Cytochrome P450 2C8 CYP2C8 0.1192
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.1172
238 Peroxisome proliferator-activated receptor gamma PPARG 0.1118
459 Retinoic acid receptor RXR-alpha RXRA 0.0995
6024 Cytochrome P450 1A1 CYP1A1 0.0955
614 Progesterone receptor PGR 0.0894
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0879
6030 Cytochrome P450 2B6 CYP2B6 0.0817
6107 Cytochrome P450 3A7 CYP3A7 0.0798
587 Serum albumin ALB 0.0758
6013 Cytochrome P450 2E1 CYP2E1 0.0751
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0743
856 Vitamin D3 receptor VDR 0.0703
6220 Aryl hydrocarbon receptor AHR 0.0702
6283 Oxysterols receptor LXR-alpha NR1H3 0.0701
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0652
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0617
1898 Cytochrome P450 1B1 CYP1B1 0.0603
1729 Solute carrier family 22 member 6 SLC22A6 0.0591
3233 Bile acid receptor NR1H4 0.0588
3811 Cytochrome P450 19A1 CYP19A1 0.0567
756 Sex hormone-binding globulin SHBG 0.0547
776 Bile salt export pump ABCB11 0.0529
6560 Nuclear receptor coactivator 5 NCOA5 0.0526
4192 DNA topoisomerase 2-beta TOP2B 0.0523
5718 Cytochrome P450 2A6 CYP2A6 0.0486
6137 Multidrug resistance-associated protein 6 ABCC6 0.0482
118 Organic cation/carnitine transporter 2 SLC22A5 0.0476
88 Retinoic acid receptor RXR-beta RXRB 0.0458
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0437
6145 Solute carrier family 22 member 1 SLC22A1 0.0431
3437 Eosinophil lysophospholipase CLC 0.0424
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0421
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0417
1353 DNA topoisomerase 1 TOP1 0.0406
3552 DNA topoisomerase 1 topA 0.0406
6144 Solute carrier family 22 member 2 SLC22A2 0.0398
20 Prostaglandin G/H synthase 1 PTGS1 0.0393
1181 Alpha-1-acid glycoprotein 1 ORM1 0.039
146 Androgen receptor AR 0.0389
6148 Multidrug resistance-associated protein 7 ABCC10 0.0379
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0375
2907 Oxysterols receptor LXR-beta NR1H2 0.0357
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0355
6142 Solute carrier family 22 member 8 SLC22A8 0.0334
290 Prostaglandin G/H synthase 2 PTGS2 0.0331
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0318
6350 Nuclear receptor subfamily 1 group I member 3 NR1I3 0.0318
2164 Multidrug resistance-associated protein 4 ABCC4 0.0305
4180 DNA-(apurinic or apyrimidinic site) lyase APEX1 0.0305
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0302
588 Chromodomain-helicase-DNA-binding protein 1 CHD1 0.0283
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0272
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0268
737 Mineralocorticoid receptor NR3C2 0.0268
6141 Sodium/bile acid cotransporter SLC10A1 0.026
36 Insulin receptor INSR 0.0258
1275 Estrogen sulfotransferase SULT1E1 0.0254
161 Tubulin beta chain TUBB 0.0246
312 Tubulin beta chain TUB2 0.0246
6143 Solute carrier family 22 member 7 SLC22A7 0.0246
1852 Microtubule-associated protein 2 MAP2 0.0246
731 HIV-1 protease HIV-1 protease 0.0244
6147 Solute carrier family 22 member 3 SLC22A3 0.0241
844 Epidermal growth factor receptor EGFR 0.0229
833 Organic cation/carnitine transporter 1 SLC22A4 0.0227
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0226
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0225
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0224
2107 Microtubule-associated protein 1A MAP1A 0.0224
2539 Tubulin alpha-1 chain TUBA4A 0.0213
556 Alpha-1A adrenergic receptor ADRA1A 0.0207
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0206
871 Glucocorticoid receptor NR3C1 0.0204
1024 Solute carrier family 22 member 11 SLC22A11 0.0201
6599 HTH-type transcriptional regulator ttgR ttgR 0.0198
824 Sodium-dependent serotonin transporter SLC6A4 0.0197
6106 Cytochrome P450 2C18 CYP2C18 0.0196
6258 Protein S100-A7 S100A7 0.0191
492 Histamine H1 receptor HRH1 0.0189
831 D(2) dopamine receptor DRD2 0.0188
4120 NADPH--cytochrome P450 reductase POR 0.0186
2404 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform PIK3CG 0.0185
723 Cytosolic phospholipase A2 PLA2G4A 0.0184
578 Endothelin-1 receptor EDNRA 0.0182
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.0181
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0178
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0173
502 5-hydroxytryptamine 2A receptor HTR2A 0.0172
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0166
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0165
318 Alpha-2A adrenergic receptor ADRA2A 0.0162
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.016
3941 Amine oxidase [flavin-containing] A MAOA 0.0159
3947 Xanthine dehydrogenase/oxidase XDH 0.0158
3923 Cholinesterase BCHE 0.0156
193 Beta-1 adrenergic receptor ADRB1 0.0156
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0153
504 Mast/stem cell growth factor receptor KIT 0.0152
4604 Liver carboxylesterase 1 CES1 0.015
3809 Estrogen-related receptor gamma ESRRG 0.0149
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0147
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0146
885 5-hydroxytryptamine 1B receptor HTR1B 0.0145
3810 Catechol O-methyltransferase COMT 0.0143
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0142
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0142
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0138
29 Tubulin beta-1 chain TUBB1 0.0137
33 Cystine/glutamate transporter SLC7A11 0.0137
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0137
23 D(1A) dopamine receptor DRD1 0.0137
6020 Aldehyde oxidase AOX1 0.0135
725 5-hydroxytryptamine 1D receptor HTR1D 0.0133
468 Cytochrome P450 4A11 CYP4A11 0.0132
520 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0132
2306 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0132
2367 UDP-N-acetylglucosamine 1-carboxyvinyltransferase murA 0.0132
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0131
632 Alpha-1B adrenergic receptor ADRA1B 0.0131
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0131
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.013
3307 Acriflavine resistance protein B acrB 0.013
320 5-hydroxytryptamine 1A receptor HTR1A 0.013
117 Sterol O-acyltransferase 1 SOAT1 0.0129
273 Apoptosis regulator Bcl-2 BCL2 0.0126
6136 Multidrug resistance-associated protein 5 ABCC5 0.0123
908 Glutathione S-transferase theta-1 GSTT1 0.0122
6085 Fatty acid-binding protein, intestinal FABP2 0.012
2183 Fatty acid-binding protein, adipocyte FABP4 0.0119
687 Tyrosine-protein phosphatase non-receptor type 1 PTPN1 0.0118
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0118
2331 HTH-type transcriptional regulator qacR qacR 0.0118
6461 HTH-type transcriptional regulator qacR qacR 0.0118
465 Calmodulin CALM1 0.0118
766 Beta-2 adrenergic receptor ADRB2 0.0117
1192 Sulfotransferase 1A1 SULT1A1 0.0116
228 Beta platelet-derived growth factor receptor PDGFRB 0.0116
380 Cytochrome P450 17A1 CYP17A1 0.0115
789 Alpha-1D adrenergic receptor ADRA1D 0.0113
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0113
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0112
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0112
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0112
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0112
904 Glutathione S-transferase P GSTP1 0.0112
738 Monocarboxylate transporter 1 SLC16A1 0.0111
590 5-hydroxytryptamine 2C receptor HTR2C 0.0109
243 Ribosyldihydronicotinamide dehydrogenase [quinone] NQO2 0.0105
26 Vascular endothelial growth factor receptor 3 FLT4 0.0105
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0105
4773 Deoxycytidine kinase DCK 0.0104
32 Vascular endothelial growth factor receptor 1 FLT1 0.01
594 Thyroxine-binding globulin SERPINA7 0.0099
3939 Amine oxidase [flavin-containing] B MAOB 0.0099
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
758 Thyroid hormone receptor alpha THRA 0.0096
5787 Angiopoietin-1 receptor TEK 0.0095
6058 Geranylgeranyl pyrophosphate synthetase GGPS1 0.0095
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0094
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0094
407 Vascular endothelial growth factor receptor 2 KDR 0.0094
381 Prolactin receptor PRLR 0.0093
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0093
346 Thyroid hormone receptor beta-1 THRB 0.0093
853 Farnesyl pyrophosphate synthetase FDPS 0.0092
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0092
629 Alpha-2B adrenergic receptor ADRA2B 0.0091
713 Sodium-dependent dopamine transporter SLC6A3 0.009
847 Mu-type opioid receptor OPRM1 0.0089
461 Glycine receptor subunit alpha-3 GLRA3 0.0089
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.0088
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0088
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0087
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0087
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0086
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0084
5923 Microtubule-associated protein tau MAPT 0.0084
5924 Microtubule-associated protein 4 MAP4 0.0084
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0084
952 Dipeptidyl peptidase 4 DPP4 0.0084
6182 Cytochrome P450 2J2 CYP2J2 0.0083
467 Delta-type opioid receptor OPRD1 0.0083
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0083
638 D(3) dopamine receptor DRD3 0.0083
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0083
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.0082
696 Kappa-type opioid receptor OPRK1 0.0082
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0081
1757 Myeloperoxidase MPO 0.0081
6167 Organic solute transporter subunit beta OSTB 0.008
6166 Organic solute transporter subunit alpha OSTA 0.008
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.008
4238 50S ribosomal protein L4 rplD 0.0078
5578 50S ribosomal protein L4 rplD 0.0078
6173 50S ribosomal protein L4 rplD 0.0078
6219 50S ribosomal protein L4 rplD 0.0078
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0077
511 5-hydroxytryptamine 1F receptor HTR1F 0.0077
70 Type-1 angiotensin II receptor AGTR1 0.0075
603 DNA polymerase alpha catalytic subunit POLA1 0.0074
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0074
571 Melatonin receptor type 1A MTNR1A 0.0072
362 Melatonin receptor type 1B MTNR1B 0.0072
4237 50S ribosomal protein L22 rplV 0.0072
2449 Tubulin alpha-3 chain TUBA1A 0.0072
777 Tumor necrosis factor TNF 0.0071
16 Adenosine A1 receptor ADORA1 0.0071
2616 Ganglioside GM2 activator GM2A 0.0071
6149 Solute carrier family 22 member 10 SLC22A10 0.0071
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0071
378 Alpha-2C adrenergic receptor ADRA2C 0.0071
183 Vascular endothelial growth factor A VEGFA 0.007
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0068
436 5-hydroxytryptamine 2B receptor HTR2B 0.0068
4210 Toll-like receptor 4 TLR4 0.0067
1178 Adenosine A2a receptor ADORA2A 0.0067
341 5-hydroxytryptamine 3 receptor HTR3A 0.0065
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0065
6138 Multidrug resistance protein 3 ABCB4 0.0065
1650 Heme carrier protein 1 SLC46A1 0.0065
260 Cytochrome P450 51 ERG11 0.0064
761 Cytochrome P450 51 ERG11 0.0064
3163 Cytochrome P450 51 cyp51 0.0064
3432 Multidrug-efflux transporter 1 regulator bmrR 0.0063
244 Angiotensin-converting enzyme ACE 0.0063
4476 Mannitol dehydrogenase mtlD 0.0063
124 Histamine H2 receptor HRH2 0.0063
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.0062
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0061
176 30S ribosomal protein S10 rpsJ 0.006
6175 30S ribosomal protein S10 rpsJ 0.006
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.006
4117 Probable pyruvate-flavodoxin oxidoreductase ydbK 0.006
165 FL cytokine receptor FLT3 0.0059
275 Arachidonate 5-lipoxygenase ALOX5 0.0058
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0057
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0057
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0057
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0057
818 50S ribosomal protein L10 rplJ 0.0057
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0057
685 Oxygen-insensitive NADPH nitroreductase nfsA 0.0057
6945 Oxygen-insensitive NADPH nitroreductase rdxA 0.0057
6168 Solute carrier family 22 member 16 SLC22A16 0.0056
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0056
6146 High affinity copper uptake protein 1 SLC31A1 0.0056
474 Acetylcholinesterase ACHE 0.0055
199 Monocarboxylate transporter 8 SLC16A2 0.0055
6031 Cytochrome P450 3A43 CYP3A43 0.0055
3917 Methylenetetrahydrofolate reductase MTHFR 0.0055
122 P2Y purinoceptor 12 P2RY12 0.0054
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0054
5626 Nucleoside diphosphate kinase B NME2 0.0054
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0054
3856 Fibroblast growth factor receptor 3 FGFR3 0.0053
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0053
2236 Casein kinase II subunit alpha CSNK2A1 0.0053
432 D(4) dopamine receptor DRD4 0.0052
887 DNA gyrase subunit B gyrB 0.0051
4150 DNA gyrase subunit B gyrB 0.0051
6225 DNA gyrase subunit B gyrB 0.0051
6836 3-hydroxyisobutyryl-CoA hydrolase, mitochondrial HIBCH 0.0051
6837 Serine/threonine-protein kinase 17B STK17B 0.0051
702 UMP-CMP kinase CMPK1 0.0051
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0051
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0051
1050 Bile salt sulfotransferase SULT2A1 0.0051
6163 Copper-transporting ATPase 2 ATP7B 0.0051
6165 Copper-transporting ATPase 1 ATP7A 0.0051
1629 Transcription factor AP-1 JUN 0.005
2599 Tyrosine-protein kinase HCK HCK 0.005
24 Thymidylate synthase TMP1 0.0049
359 Thymidylate synthase TYMS 0.0049
2626 Thymidylate synthase thyA 0.0049
2729 Thymidylate synthase thyA 0.0049
5352 Thymidylate synthase THYA 0.0049
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0049
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0049
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0049
714 Glutathione reductase, mitochondrial GSR 0.0049
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0049
896 Glutathione S-transferase Mu 1 GSTM1 0.0048
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0048
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0048
293 Gamma-glutamyl hydrolase GGH 0.0047
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0047
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0047
6014 Cytochrome P450 2A13 CYP2A13 0.0047
7 Nitric oxide synthase, inducible NOS2 0.0047
342 P protein [Includes: DNA-directed DNA polymerase P 0.0046
612 P protein [Includes: DNA-directed DNA polymerase P 0.0046
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0046
2499 Tubulin beta-2C chain TUBB2C 0.0046
239 Coagulation factor X F10 0.0046
1649 Small inducible cytokine A2 CCL2 0.0046
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0045
677 Choline-phosphate cytidylyltransferase A PCYT1A 0.0045
2981 Phospholipase A2, membrane associated PLA2G2A 0.0045
6656 UDP-glucuronosyltransferase 3A1 UGT3A1 0.0045
5294 Nucleoside diphosphate kinase A NME1 0.0044
489 Monocarboxylate transporter 2 SLC16A7 0.0044
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0044
3587 Gastrotropin FABP6 0.0044
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.0043
6755 Poliovirus receptor PVR 0.0043
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0043
1291 cAMP response element-binding protein CREB1 0.0042
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0042
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0042
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0042
6151 Monocarboxylate transporter 10 SLC16A10 0.0042
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0041
936 Ephrin type-A receptor 2 EPHA2 0.0041
716 5-hydroxytryptamine 7 receptor HTR7 0.0041
469 Annexin A1 ANXA1 0.0041
823 Fibroblast growth factor receptor 2 FGFR2 0.004
2450 Tyrosine-protein kinase ITK/TSK ITK 0.004
226 Gonadotropin-releasing hormone receptor GNRHR 0.004
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.004
6212 Tubulin gamma-1 chain TUBG1 0.004
6210 Tubulin delta chain TUBD1 0.004
6211 Tubulin epsilon chain TUBE1 0.004
1618 High affinity nerve growth factor receptor NTRK1 0.004
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.004
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.004
1517 Beta-3 adrenergic receptor ADRB3 0.0039
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0039
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0039
605 Fumarate reductase flavoprotein subunit frdA 0.0038
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0038
3673 Fumarate reductase flavoprotein subunit fccA 0.0038
4912 Fumarate reductase flavoprotein subunit ifcA 0.0038
6549 Fumarate reductase flavoprotein subunit frdA 0.0038
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0038
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0038
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0038
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.0038
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0038
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0038
4122 Histone deacetylase 2 HDAC2 0.0038
106 Cannabinoid receptor 2 CNR2 0.0037
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0037
291 Nitric-oxide synthase, endothelial NOS3 0.0037
6344 ATP synthase subunit gamma, mitochondrial ATP5C1 0.0037
6343 ATP synthase subunit beta, mitochondrial ATP5B 0.0037
6342 ATP synthase subunit alpha, mitochondrial ATP5A1 0.0037
1656 CYP2B protein CYP2B 0.0037
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0036
76 Nitric-oxide synthase, brain NOS1 0.0036
68 Cannabinoid receptor 1 CNR1 0.0036
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0036
365 Dihydrofolate reductase DHFR 0.0035
2381 Dihydrofolate reductase DFR1 0.0035
2833 Dihydrofolate reductase Not Available 0.0035
2931 Dihydrofolate reductase folA 0.0035
3544 Dihydrofolate reductase folA 0.0035
3682 Dihydrofolate reductase folA 0.0035
6642 Dihydrofolate reductase folA 0.0035
6756 Dihydrofolate reductase dfrA 0.0035
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0035
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0035
163 D(1B) dopamine receptor DRD5 0.0035
284 DNA-directed RNA polymerase beta chain rpoB 0.0035
5773 DNA-directed RNA polymerase beta chain rpoB 0.0035
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0035
6161 Probable low affinity copper uptake protein 2 SLC31A2 0.0035
5998 Toll-like receptor 8 TLR8 0.0035
6766 O-GlcNAcase BT_4395 BT_4395 0.0034
565 Extracellular calcium-sensing receptor CASR 0.0034
712 Tubulin alpha chain TUB1 0.0034
768 FK506-binding protein 1A FKBP1A 0.0034
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0034
3830 Calreticulin CALR 0.0034
2297 Genome polyprotein Not Available 0.0034
2322 Genome polyprotein Not Available 0.0034
2694 Genome polyprotein Not Available 0.0034
2719 Genome polyprotein Not Available 0.0034
2860 Genome polyprotein Not Available 0.0034
2928 Genome polyprotein Not Available 0.0034
3160 Genome polyprotein Not Available 0.0034
3260 Genome polyprotein Not Available 0.0034
4783 Genome polyprotein Not Available 0.0034
5726 Genome polyprotein Not Available 0.0034
5779 Genome polyprotein Not Available 0.0034
5867 Genome polyprotein Not Available 0.0034
6253 Genome polyprotein Not Available 0.0034
6301 Genome polyprotein Not Available 0.0034
6380 Genome polyprotein Not Available 0.0034
6381 Genome polyprotein Not Available 0.0034
6437 Genome polyprotein Not Available 0.0034
6520 Genome polyprotein Not Available 0.0034
6521 Genome polyprotein Not Available 0.0034
6652 Genome polyprotein Not Available 0.0034
6734 Genome polyprotein Not Available 0.0034
6735 Genome polyprotein Not Available 0.0034
6736 Genome polyprotein Not Available 0.0034
6737 Genome polyprotein Not Available 0.0034
6738 Genome polyprotein Not Available 0.0034
6739 Genome polyprotein Not Available 0.0034
6744 Genome polyprotein Not Available 0.0034
6748 Genome polyprotein Not Available 0.0034
6894 Genome polyprotein Not Available 0.0034
6898 Genome polyprotein Not Available 0.0034
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0034
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0034
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0033
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0033
6044 Serum paraoxonase/lactonase 3 PON3 0.0033
2347 Proto-oncogene serine/threonine-protein kinase Pim-1 PIM1 0.0033
613 Atrial natriuretic peptide receptor A NPR1 0.0033
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0033
3957 Adenosine deaminase ADA 0.0032
1760 Aminopeptidase N ANPEP 0.0032
6843 Aminopeptidase N pepN 0.0032
6259 (3R)-hydroxymyristoyl-acyl carrier protein dehydratase fabZ 0.0032
5432 Trafficking protein particle complex subunit 3 TRAPPC3 0.0032
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0032
6753 Apolipoprotein M APOM 0.0032
2528 Fatty acid metabolism regulator protein fadR 0.0032
6740 Fatty acid metabolism regulator protein fadR 0.0032
394 Calcineurin subunit B isoform 1 PPP3R1 0.0032
6742 Recoverin RCVRN 0.0032
6752 Guanylyl cyclase-activating protein 1 GUCA1A 0.0032
6743 Non-fluorescent flavoprotein luxF 0.0032
6747 Chalcone/stilbene synthase family protein MT1417 0.0032
6741 Peroxisomal 3,2-trans-enoyl-CoA isomerase PECI 0.0032
6522 Hepatocyte nuclear factor 4-alpha HNF4A 0.0032
6746 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform PPP3CA 0.0032
6751 Gag polyprotein gag 0.0032
6749 Polyprotein Not Available 0.0032
6035 Nuclear receptor ROR-beta RORB 0.0031
6034 Hydroxyindole O-methyltransferase ASMT 0.0031
6036 Eosinophil peroxidase EPX 0.0031
4103 Proteasome subunit beta type 2 PSMB2 0.0031
4102 Proteasome subunit beta type 5 PSMB5 0.0031
4101 Proteasome subunit beta type 1 PSMB1 0.0031
1063 Signal transducer and activator of transcription 5B STAT5B 0.0031
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0031
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.003
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.003
173 Toll-like receptor 7 TLR7 0.003
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.003
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.003
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.003
6824 Tyrosine-protein kinase Lyn LYN 0.003
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.003
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0029
3950 Cell division protein kinase 9 CDK9 0.0029
3968 Cell division protein kinase 8 CDK8 0.0029
5818 Folate receptor alpha FOLR1 0.0029
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0029
1010 Cytochrome P450 51A1 CYP51A1 0.0029
683 Potassium transporter GK0582 0.0029
6043 Putative G-protein coupled receptor 44 GPR44 0.0028
1435 Synaptic vesicle glycoprotein 2A SV2A 0.0028
484 Tyrosine-protein kinase ABL2 ABL2 0.0028
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0028
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0028
78 Acetyl-CoA acetyltransferase, mitochondrial ACAT1 0.0028
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0028
5961 Insulin INS 0.0028
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0028
6527 Lymphocyte antigen 96 LY96 0.0028
6232 Guanine nucleotide-binding protein G(s) subunit alpha isoforms short GNAS 0.0027
6233 Adenylate cyclase type 2 ADCY2 0.0027
6234 Adenylate cyclase type 5 ADCY5 0.0027
6432 Transporter snf 0.0027
765 Indoleamine 2,3-dioxygenase IDO1 0.0027
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0026
427 Substance-P receptor TACR1 0.0026
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.0026
790 DNA polymerase subunit alpha B POLA2 0.0026
5997 Tumor necrosis factor ligand superfamily member 11 TNFSF11 0.0026
804 Mitochondrial folate transporter/carrier SLC25A32 0.0026
718 Folate receptor gamma FOLR3 0.0026
299 Folate receptor beta FOLR2 0.0026
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0026
6750 ADP-ribosylation factor 6 ARF6 0.0026
4373 Medium-chain-fatty-acid--CoA ligase Not Available 0.0025
6524 Protein tonB tonB 0.0025
94 5-hydroxytryptamine 4 receptor HTR4 0.0025
6859 Protein S100-A4 S100A4 0.0025
3959 Cell division protein kinase 4 CDK4 0.0025
2021 Thrombomodulin THBD 0.0025
1385 Angiotensin-converting enzyme 2 ACE2 0.0025
5880 Thrombopoietin receptor MPL 0.0025
6316 ADP-ribosylation factor 1 ARF1 0.0025
3482 Cell division protein kinase 7 CDK7 0.0025
921 Glutamate receptor 2 GRIA2 0.0025
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0024
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0024
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0024
185 Vasopressin V1a receptor AVPR1A 0.0024
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0024
4226 Uridine phosphorylase 2 UPP2 0.0024
319 Opioid receptor, sigma 1 OPRS1 0.0024
4148 Serine/threonine-protein kinase mTOR MTOR 0.0024
322 Vasopressin V2 receptor AVPR2 0.0024
6070 Nischarin NISCH 0.0024
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0024
1256 5-hydroxytryptamine 6 receptor HTR6 0.0024
6171 Solute carrier family 28 member 3 SLC28A3 0.0024
2216 Fibroblast growth factor receptor 4 FGFR4 0.0024
3955 Cell division protein kinase 6 CDK6 0.0023
4221 Vascular endothelial growth factor VEGF 0.0023
5816 Cadherin-5 CDH5 0.0023
4217 Telomerase reverse transcriptase TERT 0.0023
1864 RET proto-oncogene RET 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0023
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0023
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0023
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.0023
2435 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0023
6613 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase lpxC 0.0023
4225 Uridine phosphorylase 1 UPP1 0.0022
760 Fibroblast growth factor 1 FGF1 0.0022
773 Folylpolyglutamate synthase, mitochondrial FPGS 0.0022
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0022
6111 DNA polymerase epsilon subunit 4 POLE4 0.0022
6112 DNA polymerase epsilon subunit 3 POLE3 0.0022
6110 DNA polymerase epsilon subunit 2 POLE2 0.0022
6108 Ribonucleoside-diphosphate reductase subunit M2 B RRM2B 0.0022
6109 DNA polymerase epsilon catalytic subunit A POLE 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
1313 Lactoylglutathione lyase GLO1 0.0022
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0021
528 5-hydroxytryptamine 1E receptor HTR1E 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
6218 Pannexin-1 PANX1 0.0021
413 Amidophosphoribosyltransferase PPAT 0.0021
2515 Amidophosphoribosyltransferase purF 0.0021
3714 Amidophosphoribosyltransferase purF 0.0021
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0021
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0021
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0021
864 Gag-Pol polyprotein gag-pol 0.002
2237 Gag-Pol polyprotein gag-pol 0.002
2326 Gag-Pol polyprotein gag-pol 0.002
2451 Gag-Pol polyprotein gag-pol 0.002
2901 Gag-Pol polyprotein gag-pol 0.002
3165 Gag-Pol polyprotein gag-pol 0.002
3722 Gag-Pol polyprotein gag-pol 0.002
6306 Gag-Pol polyprotein gag-pol 0.002
6624 Gag-Pol polyprotein gag-pol 0.002
1742 D-HSCDK2 CDK2deltaT 0.002
1771 Cell division control protein 2 homolog CDK1 0.002
3321 Cell division control protein 2 homolog CRK2 0.002
2287 Bifunctional purine biosynthesis protein PURH [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase ATIC 0.002
4218 Ribonucleoside-diphosphate reductase M2 subunit RRM2 0.002
1820 Beta-nerve growth factor NGF 0.002
2240 Cell division protein kinase 2 CDK2 0.002
1058 Cell division protein kinase 5 CDK5 0.002
4228 Keratin, type II cytoskeletal 7 KRT7 0.002
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0019
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.0019
5798 Mitogen-activated protein kinase 11 MAPK11 0.0019
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0019
6042 Prostaglandin reductase 2 PTGR2 0.0019
512 DNA-directed RNA polymerase alpha chain rpoA 0.0019
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0019
2320 Thymidine kinase, cytosolic TK1 0.0019
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0019
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0018
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0018
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0018
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.0018
6102 Arylamine N-acetyltransferase 2 NAT2 0.0018
2391 Ferrochelatase hemH 0.0018
6502 Ferrochelatase DKFZp686P18130 0.0018
1591 Ferrochelatase, mitochondrial FECH 0.0018
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0018
2427 Ferrichrome-iron receptor fhuA 0.0018
1714 Mitogen-activated protein kinase 3 MAPK3 0.0018
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.0018
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.0018
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.0018
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.0018
811 Translocator protein TSPO 0.0018
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0018
1792 Tissue-type plasminogen activator PLAT 0.0017
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0017
229 Retinoic acid receptor beta RARB 0.0017
780 Retinoic acid receptor RXR-gamma RXRG 0.0017
3639 Thymidine phosphorylase deoA 0.0017
3936 Thymidine phosphorylase TYMP 0.0017
1648 Elastin ELN 0.0017
730 Retinoic acid receptor alpha RARA 0.0017
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0017
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.0017
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0017
1830 5'-nucleotidase NT5E 0.0016
4311 tRNA TRDMT1 0.0016
4325 tRNA trmD 0.0016
4328 tRNA trmD 0.0016
390 Adenosine A3 receptor ADORA3 0.0016
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0016
6264 cAMP-dependent protein kinase inhibitor alpha PKIA 0.0016
5300 Antigen peptide transporter 1 TAP1 0.0016
1243 Cathepsin D CTSD 0.0016
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0016
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0016
6495 Cytochrome c oxidase subunit 7C, mitochondrial COX7C 0.0016
6497 Cytochrome c oxidase subunit 6A2, mitochondrial COX6A2 0.0015
6493 Cytochrome c oxidase subunit 6C COX6C 0.0015
6494 Cytochrome c oxidase subunit 7B, mitochondrial COX7B 0.0015
6498 Cytochrome c oxidase subunit 6B1 COX6B1 0.0015
6496 Cytochrome c oxidase subunit 8A, mitochondrial COX8A 0.0015
6499 Cytochrome c oxidase polypeptide 7A1, mitochondrial COX7A1 0.0015
6491 Cytochrome c oxidase subunit 5A, mitochondrial COX5A 0.0015
6489 Cytochrome c oxidase subunit 4 isoform 1, mitochondrial COX4I1 0.0015
6490 Cytochrome c oxidase subunit 3 MT-CO3 0.0015
5793 Cytochrome c oxidase subunit 2 MT-CO2 0.0015
6559 Cytochrome c oxidase subunit 2 ctaC 0.0015
6669 Cytochrome c oxidase subunit 2 ctaC 0.0015
162 Retinoic acid receptor gamma-1 RARG 0.0015
371 Cytochrome c oxidase subunit 1 MT-CO1 0.0015
6558 Cytochrome c oxidase subunit 1 ctaD 0.0015
3932 Glutathione S-transferase A2 GSTA2 0.0015
517 Alcohol dehydrogenase 1C ADH1C 0.0015
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1770 Phospholipase C PLCL1 0.0015
2841 Phospholipase C plc 0.0015
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0015
2540 Choloylglycine hydrolase cbh 0.0014
976 Platelet glycoprotein IX GP9 0.0014
2129 Sucrase-isomaltase, intestinal SI 0.0014
1374 Natriuretic peptides B NPPB 0.0014
1827 Gap junction alpha-1 protein GJA1 0.0014
1908 Vascular cell adhesion protein 1 VCAM1 0.0014
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0014
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0014
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0014
84 Nuclear receptor 0B1 NR0B1 0.0014
2091 Endoplasmin HSP90B1 0.0014
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0014
277 Purine nucleoside phosphorylase PNP 0.0014
2870 Purine nucleoside phosphorylase punA 0.0014
2945 Purine nucleoside phosphorylase punA 0.0014
4659 Purine nucleoside phosphorylase TM_1596 0.0014
4825 Purine nucleoside phosphorylase TTHA1435 0.0014
814 Ryanodine receptor 1 RYR1 0.0013
6501 Fatty acid-binding protein, liver FABP1 0.0013
1152 Glycogen phosphorylase, muscle form PYGM 0.0013
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0013
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0013
543 Penicillin-binding protein 1B mrcB 0.0013
6186 Penicillin-binding protein 1B ponB 0.0013
6822 Penicillin-binding protein 1b pbp1b 0.0013
6844 Penicillin-binding protein 1b pbp1b 0.0013
645 Penicillin-binding protein 1A mrcA 0.0013
5805 Penicillin-binding protein 1A ponA 0.0013
6185 Penicillin-binding protein 1A mrcA 0.0013
6799 Penicillin-binding protein 1A pbpA 0.0013
159 Penicillin-binding protein 2B penA 0.0013
6121 Penicillin-binding protein 2B penA 0.0013
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0013
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0012
3382 Glycolipid transfer protein GLTP 0.0012
694 Matrix protein 2 M 0.0012
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0012
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0012
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0012
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0012
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.0012
518 Peroxidase/catalase T katG 0.0012
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0012
54 Prothrombin F2 0.0011
482 Glycine receptor subunit alpha-1 GLRA1 0.0011
828 Phenylalanine-4-hydroxylase PAH 0.0011
3109 Phenylalanine-4-hydroxylase phhA 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
2112 Toll-like receptor 9 TLR9 0.0011
6500 Phospholipase A2 PLA2G1B 0.0011
563 Thyroid peroxidase TPO 0.0011
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0011
2300 Lysozyme E 0.0011
3633 Lysozyme R 0.0011
5597 Lysozyme 17 0.0011
6459 Glycodelin PAEP 0.0011
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0011
232 Corticosteroid-binding globulin SERPINA6 0.0011
131 Synaptic vesicular amine transporter SLC18A2 0.0011
634 Squalene monooxygenase SQLE 0.001
7196 Squalene monooxygenase ERG1 0.001
144 Hemoglobin subunit alpha HBA1 0.001
6174 50S ribosomal protein L32 rpmF 0.001
4203 Histamine N-methyltransferase HNMT 0.001
2101 Glutathione-requiring prostaglandin D synthase HPGDS 0.001
2473 Tyrosine-protein kinase CSK CSK 0.001
2398 Tyrosine-protein kinase ZAP-70 ZAP70 0.001
476 RAC-alpha serine/threonine-protein kinase AKT1 0.001
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.001
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.001
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.001
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.001
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.001
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.001
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.001
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.001
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.001
65 Matrix metalloproteinase-9 Not Available 0.001
1928 Leukotriene C4 synthase LTC4S 0.001
4043 Glutaredoxin-2, mitochondrial GLRX2 0.001
4034 Glutaredoxin-1 GLRX 0.001
910 Epididymal secretory glutathione peroxidase GPX5 0.001
4036 Glutathione peroxidase 6 GPX6 0.001
4037 Hypothetical protein GPX1 0.001
4297 Hypothetical protein SP_1951 0.001
4521 Hypothetical protein BC_2969 0.001
4540 Hypothetical protein TM_1070 0.001
4555 Hypothetical protein MT1739 0.001
4569 Hypothetical protein mshD 0.001
4578 Hypothetical protein PA3270 0.001
4747 Hypothetical protein PA3967 0.001
5177 Hypothetical protein TM_0096 0.001
5194 Hypothetical protein PA1204 0.001
5240 Hypothetical protein Rv2991 0.001
5370 Hypothetical protein TM_1158 0.001
5710 Hypothetical protein Tb927.5.1360 0.001
4029 Microsomal glutathione S-transferase 3 MGST3 0.001
900 Glutathione S-transferase A4 GSTA4 0.001
4030 Thioredoxin domain-containing protein 12 TXNDC12 0.001
911 Glutathione peroxidase 3 GPX3 0.001
4040 Glutathione peroxidase 7 GPX7 0.001
907 Glutathione peroxidase 2 GPX2 0.001
4032 Microsomal glutathione S-transferase 1 MGST1 0.001
906 Glutathione peroxidase 1 GPX1 0.001
4039 CDNA FLJ23636 fis, clone CAS07176 GPX8 0.001
4035 Glutathione S-transferase Mu 5 GSTM5 0.001
903 Glutathione S-transferase A5 GSTA5 0.001
4042 Glutathione transferase omega-2 GSTO2 0.001
4033 S-formylglutathione hydrolase ESD 0.001
4038 Glutathione peroxidase 4 GPX4 0.001
1975 Phospholipid hydroperoxide glutathione peroxidase, mitochondrial GPX4 0.001
1056 Gamma-glutamyltranspeptidase 1 GGT1 0.001
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.001
444 Alcohol dehydrogenase 1B ADH1B 0.0009
5934 Cytochrome P450 26A1 CYP26A1 0.0009
3611 Cytidine deaminase cdd 0.0009
3707 Cytidine deaminase cdd 0.0009
4211 Cytidine deaminase CDA 0.0009
751 Potassium channel subfamily K member 6 KCNK6 0.0009
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.0009
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0009
1525 Heparin-binding growth factor 2 FGF2 0.0009
1569 G1/S-specific cyclin-D1 CCND1 0.0009
3319 Hydroxyacylglutathione hydrolase HAGH 0.0009
898 Glutathione S-transferase A3 GSTA3 0.0009
897 Glutathione S-transferase kappa 1 GSTK1 0.0009
1360 Sphingomyelin phosphodiesterase SMPD1 0.0009
909 Maleylacetoacetate isomerase GSTZ1 0.0009
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0009
1262 Corticotropin-lipotropin POMC 0.0009
172 Potassium channel subfamily K member 1 KCNK1 0.0008
899 Glutathione S-transferase Mu 3 GSTM3 0.0008
905 Glutathione transferase omega-1 GSTO1 0.0008
4041 Microsomal glutathione S-transferase 2 MGST2 0.0008
3616 Fatty acid-binding protein, epidermal FABP5 0.0008
5433 UPF0230 protein TM_1468 TM_1468 0.0008
5430 Hepatocyte nuclear factor 4-gamma HNF4G 0.0008
5431 Lipid binding protein Not Available 0.0008
2165 Glutathione S-transferase Mu 2 GSTM2 0.0008
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0008
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0008
6100 BDNF/NT-3 growth factors receptor NTRK2 0.0008
2530 Protein kinase C theta type PRKCQ 0.0008
207 Glutathione synthetase GSS 0.0008
5269 Glutathione synthetase gshB 0.0008
400 Coagulation factor IX F9 0.0008
5461 Coagulation factor IX F9 0.0008
901 Glutathione S-transferase Mu 4 GSTM4 0.0007
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.0007
822 Aldose reductase AKR1B1 0.0007
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0007
604 Vitamin K-dependent protein Z PROZ 0.0007
283 SEC14-like protein 2 SEC14L2 0.0007
2408 Tyrosine-protein kinase SYK SYK 0.0007
2511 MAP kinase-activated protein kinase 2 MAPKAPK2 0.0007
251 Alcohol dehydrogenase 1A ADH1A 0.0007
295 Carbonic anhydrase 1 CA1 0.0007
705 Glutamate receptor 1 GRIA1 0.0007
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0007
4031 Glutathione S-transferase A1 GSTA1 0.0007
1630 Integrin beta-2 ITGB2 0.0007
2211 Fatty acid-binding protein, heart FABP3 0.0007
820 Glycine receptor subunit alpha-2 GLRA2 0.0006
268 Adenosine A2b receptor ADORA2B 0.0006
1245 Vitamin K-dependent protein S PROS1 0.0006
422 Vitamin K-dependent protein C PROC 0.0006
537 ATP synthase delta chain, mitochondrial ATP5D 0.0006
6677 Myelin P2 protein PMP2 0.0006
1176 Mitogen-activated protein kinase 1 MAPK1 0.0006
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0006
174 Sigma 1-type opioid receptor SIGMAR1 0.0006
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0006
6048 Troponin C, skeletal muscle TNNC2 0.0006
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0006
164 Histamine H4 receptor HRH4 0.0006
1721 Glycogen synthase kinase-3 beta GSK3B 0.0005
3238 Multidrug resistance protein mexA mexA 0.0005
3116 Bacterioferritin bfr 0.0005
4906 Bacterioferritin bfr 0.0005
4965 Bacterioferritin bfr 0.0005
3173 Enolase eno 0.0005
3709 Glycerol uptake facilitator protein glpF 0.0005
3336 C4-dicarboxylate transport transcriptional regulatory protein dctD dctD 0.0005
3393 TGF-beta receptor type-2 TGFBR2 0.0005
5489 Ribonucleoside-diphosphate reductase 1 subunit beta nrdB 0.0005
153 Dopamine beta-hydroxylase DBH 0.0005
798 Osteocalcin BGLAP 0.0005
2207 Rhodopsin RHO 0.0005
572 Integrin alpha-L ITGAL 0.0005
1039 Histone deacetylase 9 HDAC9 0.0005
233 Potassium channel subfamily K member 2 KCNK2 0.0005
2852 DNA mismatch repair protein mutL mutL 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
369 Coagulation factor VII F7 0.0005
3937 Fatty-acid amide hydrolase FAAH 0.0005
5278 Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthetase 1 PAPSS1 0.0005
3191 Histidinol dehydrogenase hisD 0.0005
3221 Cytochrome c4 cc4 0.0005
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0004
4692 A/G-specific adenine glycosylase mutY 0.0004
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.0004
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.0004
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.0004
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0004
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0004
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0004
2802 Endoglucanase G celCCG 0.0004
340 Apoptotic protease-activating factor 1 APAF1 0.0004
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0004
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0004
825 Arsenical pump-driving ATPase ASNA1 0.0003
3435 Arsenical pump-driving ATPase arsA 0.0003
486 Serine/threonine-protein kinase ALS2CR7 CDK15 0.0003
2105 ATP-binding cassette sub-family G member 1 ABCG1 0.0003
377 Beta-adrenergic receptor kinase 1 ADRBK1 0.0003
510 Serine/threonine-protein kinase receptor R3 ACVRL1 0.0003
733 Activin receptor type 1B ACVR1B 0.0003
225 NEDD8-activating enzyme E1 regulatory subunit NAE1 0.0003
745 Anti-Muellerian hormone type-2 receptor AMHR2 0.0003
483 A-Raf proto-oncogene serine/threonine-protein kinase ARAF 0.0003
21 Beta-adrenergic receptor kinase 2 ADRBK2 0.0003
154 AFG3-like protein 2 AFG3L2 0.0003
395 ALK tyrosine kinase receptor Not Available 0.0003
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0003
6270 Group IIE secretory phospholipase A2 PLA2G2E 0.0003
292 Activin receptor type-1 ACVR1 0.0003
849 Activated CDC42 kinase 1 TNK2 0.0003
704 Long-chain-fatty-acid--CoA ligase 1 ACSL1 0.0003
821 Acetyl-coenzyme A synthetase 2-like, mitochondrial ACSS1 0.0003
386 Acetyl-coenzyme A synthetase, cytoplasmic ACSS2 0.0003
297 Adenylate cyclase type 1 ADCY1 0.0003
289 Cytosolic purine 5'-nucleotidase NT5C2 0.0003
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0003
740 Argininosuccinate synthase ASS1 0.0002
865 Argininosuccinate synthase ASS1 0.0002
2680 Argininosuccinate synthase argG 0.0002
3194 Argininosuccinate synthase argG 0.0002
661 ADP/ATP translocase 1 SLC25A4 0.0002
6021 Adenosine kinase ADK 0.0002
242 Asparagine synthetase [glutamine-hydrolyzing] ASNS 0.0002
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