DT-Web

DB01087 - Primaquine


Identification
Name Primaquine
Accession Number DB01087 (APRD00604)
Type small molecule
Description An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
Structure
MOL SDF PDB SMILES InChI
Categories (*)
Molecular Weight 259.3467
Groups approved
Monoisotopic Weight 259.168462309
Pharmacology
Indication For the treatment of malaria.
Mechanism of action Primaquine's mechanism of action is not well understood. It may be acting by generating reactive oxygen species or by interfering with the electron transport in the parasite. Also, although its mechanism of action is unclear, primaquine may bind to and alter the properties of protozoal DNA.
Absorption Not Available
Protein binding Not Available
Biotransformation Not Available
Route of elimination Not Available
Toxicity Not Available
Affected organisms
  • Plasmodium
Interactions
Drug Interactions
Drug Mechanism of interaction
Artemether Primaquine may increase the adverse effects of artemether. Combination therapy is contraindicated unless there are no other treatment options.
Lumefantrine Primaquine may increase the adverse effects of lumefantrine. Combination therapy is contraindicated unless there are no other treatment options.
Tacrine The metabolism of Tacrine, a CYP1A2 substrate, may be reduced by strong CYP1A2 inhibitors such as Primaquine. Consider modifying therapy to avoid Tacrine toxicity. Monitor the efficacy and toxicity of Tacrine if Primaquine is initiated, discontinued or if the dose is changed.
Thiothixene The strong CYP1A2 inhibitor, Primaquine, may decrease the metabolism and clearance of Thiothixene, a CYP1A2 substrate. Consider alternate therapy or monitor for changes in Thiothixene therapeutic and adverse effects if Primaquine is initiated, discontinued or dose changed.
Tizanidine Primaquine may decrease the metabolism and clearance of Tizanidine. Consider alternate therapy or use caution during co-administration.
Food Interactions
  • Take with food to decrease dyspepsia.

Targets


Ferriprotoporphyrin IX
Name Ferriprotoporphyrin IX
Gene Name Not Available
Pharmacological action yes
Actions antagonist
References
  • Dorn A, Vippagunta SR, Matile H, Jaquet C, Vennerstrom JL, Ridley RG: An assessment of drug-haematin binding as a mechanism for inhibition of haematin polymerisation by quinoline antimalarials. Biochem Pharmacol. 1998 Mar 15;55(6):727-36. - Pubmed
  • Fitch CD: Ferriprotoporphyrin IX, phospholipids, and the antimalarial actions of quinoline drugs. Life Sci. 2004 Mar 5;74(16):1957-72. - Pubmed
DTHybrid score Not Available
Keratin, type II cytoskeletal 7
Name Keratin, type II cytoskeletal 7
Gene Name KRT7
Pharmacological action unknown
Actions other/unknown
References
  • Heard CM, Monk BV, Modley AJ: Binding of primaquine to epidermal membranes and keratin. Int J Pharm. 2003 May 12;257(1-2):237-44. - Pubmed
  • Basso LG, Rodrigues RZ, Naal RM, Costa-Filho AJ: Effects of the antimalarial drug primaquine on the dynamic structure of lipid model membranes. Biochim Biophys Acta. 2010 Aug 14. - Pubmed
DTHybrid score 0.3263
Ribosyldihydronicotinamide dehydrogenase [quinone]
Name Ribosyldihydronicotinamide dehydrogenase [quinone]
Gene Name NQO2
Pharmacological action unknown
Actions inhibitor
References
  • Graves PR, Kwiek JJ, Fadden P, Ray R, Hardeman K, Coley AM, Foley M, Haystead TA: Discovery of novel targets of quinoline drugs in the human purine binding proteome. Mol Pharmacol. 2002 Dec;62(6):1364-72. - Pubmed
DTHybrid score 0.8146

Enzymes


Cytochrome P450 3A4
Name Cytochrome P450 3A4
Gene Name CYP3A4
Actions substrate,inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.5182
Cytochrome P450 1A2
Name Cytochrome P450 1A2
Gene Name CYP1A2
Actions substrate,inhibitor,inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.4611
Cytochrome P450 2D6
Name Cytochrome P450 2D6
Gene Name CYP2D6
Actions inhibitor
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.437
Cytochrome P450 1A1
Name Cytochrome P450 1A1
Gene Name CYP1A1
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.3583
Cytochrome P450 1B1
Name Cytochrome P450 1B1
Gene Name CYP1B1
Actions inducer
References
  • Preissner S, Kroll K, Dunkel M, Senger C, Goldsobel G, Kuzman D, Guenther S, Winnenburg R, Schroeder M, Preissner R: SuperCYP: a comprehensive database on Cytochrome P450 enzymes including a tool for analysis of CYP-drug interactions. Nucleic Acids Res. 2010 Jan;38(Database issue):D237-43. Epub 2009 Nov 24. - Pubmed
DTHybrid score 0.2629

Predictions


Id Partner name Gene Name Score
4757 Cytochrome P450 2C9 CYP2C9 0.1919
1588 Multidrug resistance protein 1 ABCB1 0.1817
6016 Cytochrome P450 2C19 CYP2C19 0.1736
4118 Cytochrome P450 3A5 CYP3A5 0.1494
4924 Cytochrome P450 2C8 CYP2C8 0.1395
6013 Cytochrome P450 2E1 CYP2E1 0.1264
6030 Cytochrome P450 2B6 CYP2B6 0.1103
6107 Cytochrome P450 3A7 CYP3A7 0.1008
5718 Cytochrome P450 2A6 CYP2A6 0.082
1732 ATP-binding cassette sub-family G member 2 ABCG2 0.0749
2936 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.068
5184 Oxygen-insensitive NAD(P)H nitroreductase nfnB 0.068
492 Histamine H1 receptor HRH1 0.0533
587 Serum albumin ALB 0.0511
20 Prostaglandin G/H synthase 1 PTGS1 0.0498
824 Sodium-dependent serotonin transporter SLC6A4 0.0411
1181 Alpha-1-acid glycoprotein 1 ORM1 0.0405
3811 Cytochrome P450 19A1 CYP19A1 0.0405
540 Sodium-dependent noradrenaline transporter SLC6A2 0.0403
831 D(2) dopamine receptor DRD2 0.0392
862 Multidrug resistance-associated protein 1 ABCC1 0.039
3947 Xanthine dehydrogenase/oxidase XDH 0.0385
502 5-hydroxytryptamine 2A receptor HTR2A 0.0382
556 Alpha-1A adrenergic receptor ADRA1A 0.0379
1735 Canalicular multispecific organic anion transporter 1 ABCC2 0.0375
6106 Cytochrome P450 2C18 CYP2C18 0.0364
6145 Solute carrier family 22 member 1 SLC22A1 0.0364
318 Alpha-2A adrenergic receptor ADRA2A 0.0347
136 Estrogen receptor ESR1 0.0347
193 Beta-1 adrenergic receptor ADRB1 0.0332
766 Beta-2 adrenergic receptor ADRB2 0.033
290 Prostaglandin G/H synthase 2 PTGS2 0.0328
776 Bile salt export pump ABCB11 0.0322
103 Muscarinic acetylcholine receptor M1 CHRM1 0.0321
6144 Solute carrier family 22 member 2 SLC22A2 0.032
1490 Solute carrier organic anion transporter family member 1B1 SLCO1B1 0.0319
6018 UDP-glucuronosyltransferase 1-9 UGT1A9 0.0308
220 Sodium channel protein type 5 subunit alpha SCN5A 0.0302
6139 Solute carrier organic anion transporter family member 1A2 SLCO1A2 0.0294
6017 Cholesterol side-chain cleavage enzyme, mitochondrial CYP11A1 0.0289
468 Cytochrome P450 4A11 CYP4A11 0.0288
817 DNA topoisomerase 2-alpha TOP2A 0.0282
320 5-hydroxytryptamine 1A receptor HTR1A 0.0279
590 5-hydroxytryptamine 2C receptor HTR2C 0.027
23 D(1A) dopamine receptor DRD1 0.0268
871 Glucocorticoid receptor NR3C1 0.0267
1729 Solute carrier family 22 member 6 SLC22A6 0.0267
6022 UDP-glucuronosyltransferase 1-1 UGT1A1 0.0266
36 Insulin receptor INSR 0.0258
6178 UDP-glucuronosyltransferase 2B7 UGT2B7 0.0256
118 Organic cation/carnitine transporter 2 SLC22A5 0.0249
385 Potassium-transporting ATPase alpha chain 1 ATP4A 0.0238
713 Sodium-dependent dopamine transporter SLC6A3 0.0238
341 5-hydroxytryptamine 3 receptor HTR3A 0.0236
632 Alpha-1B adrenergic receptor ADRA1B 0.0236
617 Muscarinic acetylcholine receptor M2 CHRM2 0.0232
465 Calmodulin CALM1 0.023
101 Potassium voltage-gated channel subfamily H member 2 KCNH2 0.0226
3941 Amine oxidase [flavin-containing] A MAOA 0.0224
6147 Solute carrier family 22 member 3 SLC22A3 0.0219
4604 Liver carboxylesterase 1 CES1 0.0218
51 Muscarinic acetylcholine receptor M3 CHRM3 0.0218
885 5-hydroxytryptamine 1B receptor HTR1B 0.0214
847 Mu-type opioid receptor OPRM1 0.0211
6142 Solute carrier family 22 member 8 SLC22A8 0.0209
373 Transthyretin TTR 0.0205
872 Gamma-aminobutyric-acid receptor subunit alpha-1 GABRA1 0.0199
2236 Casein kinase II subunit alpha CSNK2A1 0.0197
638 D(3) dopamine receptor DRD3 0.0194
24 Thymidylate synthase TMP1 0.0193
359 Thymidylate synthase TYMS 0.0193
2626 Thymidylate synthase thyA 0.0193
2729 Thymidylate synthase thyA 0.0193
5352 Thymidylate synthase THYA 0.0193
629 Alpha-2B adrenergic receptor ADRA2B 0.019
6148 Multidrug resistance-associated protein 7 ABCC10 0.0188
54 Prothrombin F2 0.0187
571 Melatonin receptor type 1A MTNR1A 0.0184
362 Melatonin receptor type 1B MTNR1B 0.0184
6220 Aryl hydrocarbon receptor AHR 0.018
833 Organic cation/carnitine transporter 1 SLC22A4 0.0177
6157 Solute carrier organic anion transporter family member 1B3 SLCO1B3 0.0174
725 5-hydroxytryptamine 1D receptor HTR1D 0.0173
6014 Cytochrome P450 2A13 CYP2A13 0.017
1757 Myeloperoxidase MPO 0.017
378 Alpha-2C adrenergic receptor ADRA2C 0.017
16 Adenosine A1 receptor ADORA1 0.0168
467 Delta-type opioid receptor OPRD1 0.0167
477 DNA topoisomerase 4 subunit A parC 0.0162
886 DNA topoisomerase 4 subunit A parC 0.0162
6226 DNA topoisomerase 4 subunit A parC 0.0162
1178 Adenosine A2a receptor ADORA2A 0.0162
274 Muscarinic acetylcholine receptor M5 CHRM5 0.0162
731 HIV-1 protease HIV-1 protease 0.016
404 DNA gyrase subunit A gyrA 0.016
6224 DNA gyrase subunit A gyrA 0.016
3830 Calreticulin CALR 0.0159
450 Muscarinic acetylcholine receptor M4 CHRM4 0.0157
485 cGMP-inhibited 3',5'-cyclic phosphodiesterase A PDE3A 0.0156
6143 Solute carrier family 22 member 7 SLC22A7 0.0156
789 Alpha-1D adrenergic receptor ADRA1D 0.0154
1709 Canalicular multispecific organic anion transporter 2 ABCC3 0.0153
777 Tumor necrosis factor TNF 0.0153
6034 Hydroxyindole O-methyltransferase ASMT 0.0152
6035 Nuclear receptor ROR-beta RORB 0.0152
6036 Eosinophil peroxidase EPX 0.0152
696 Kappa-type opioid receptor OPRK1 0.0151
1284 Nuclear receptor subfamily 1 group I member 2 NR1I2 0.0149
6101 Dimethylaniline monooxygenase [N-oxide-forming] 3 FMO3 0.0148
4115 Voltage-dependent L-type calcium channel subunit alpha-1D CACNA1D 0.0147
3939 Amine oxidase [flavin-containing] B MAOB 0.0147
432 D(4) dopamine receptor DRD4 0.0146
964 Voltage-dependent T-type calcium channel subunit alpha-1H CACNA1H 0.0144
478 Voltage-dependent L-type calcium channel subunit alpha-1C CACNA1C 0.0144
4203 Histamine N-methyltransferase HNMT 0.0143
6104 Dimethylaniline monooxygenase [N-oxide-forming] 1 FMO1 0.0143
4111 Voltage-dependent L-type calcium channel subunit alpha-1S CACNA1S 0.0142
204 cGMP-specific 3',5'-cyclic phosphodiesterase PDE5A 0.0137
3923 Cholinesterase BCHE 0.0137
146 Androgen receptor AR 0.0135
6031 Cytochrome P450 3A43 CYP3A43 0.0134
198 Sodium channel protein type 10 subunit alpha SCN10A 0.0132
260 Cytochrome P450 51 ERG11 0.0131
761 Cytochrome P450 51 ERG11 0.0131
3163 Cytochrome P450 51 cyp51 0.0131
765 Indoleamine 2,3-dioxygenase IDO1 0.0131
787 Vitamin K epoxide reductase complex subunit 1 VKORC1 0.0131
2157 NAD(P)H dehydrogenase [quinone] 1 NQO1 0.013
1632 Solute carrier organic anion transporter family member 2B1 SLCO2B1 0.0129
380 Cytochrome P450 17A1 CYP17A1 0.0125
844 Epidermal growth factor receptor EGFR 0.0124
613 Atrial natriuretic peptide receptor A NPR1 0.0122
605 Fumarate reductase flavoprotein subunit frdA 0.0121
2709 Fumarate reductase flavoprotein subunit SO_0970 0.0121
3673 Fumarate reductase flavoprotein subunit fccA 0.0121
4912 Fumarate reductase flavoprotein subunit ifcA 0.0121
6549 Fumarate reductase flavoprotein subunit frdA 0.0121
48 Pyridoxal kinase PDXK 0.0116
1517 Beta-3 adrenergic receptor ADRB3 0.0115
2449 Tubulin alpha-3 chain TUBA1A 0.0113
2499 Tubulin beta-2C chain TUBB2C 0.0113
6020 Aldehyde oxidase AOX1 0.0111
541 cAMP-specific 3',5'-cyclic phosphodiesterase 4B PDE4B 0.011
805 Cytochrome P450 11B1, mitochondrial CYP11B1 0.011
436 5-hydroxytryptamine 2B receptor HTR2B 0.0109
4110 Voltage-dependent L-type calcium channel subunit beta-2 CACNB2 0.0109
1629 Transcription factor AP-1 JUN 0.0108
6176 UDP-glucuronosyltransferase 1-3 UGT1A3 0.0107
4099 Gamma-aminobutyric-acid receptor subunit beta-3 GABRB3 0.0106
400 Coagulation factor IX F9 0.0105
5461 Coagulation factor IX F9 0.0105
4120 NADPH--cytochrome P450 reductase POR 0.0102
273 Apoptosis regulator Bcl-2 BCL2 0.0102
474 Acetylcholinesterase ACHE 0.0102
580 Gamma-aminobutyric-acid receptor subunit alpha-3 GABRA3 0.0102
614 Progesterone receptor PGR 0.0101
423 Gamma-aminobutyric-acid receptor subunit alpha-2 GABRA2 0.0101
1714 Mitogen-activated protein kinase 3 MAPK3 0.0101
1010 Cytochrome P450 51A1 CYP51A1 0.0101
6025 UDP-glucuronosyltransferase 1-4 UGT1A4 0.0101
535 Voltage-dependent T-type calcium channel subunit alpha-1G CACNA1G 0.01
2164 Multidrug resistance-associated protein 4 ABCC4 0.01
504 Mast/stem cell growth factor receptor KIT 0.01
15 Voltage-dependent T-type calcium channel subunit alpha-1I CACNA1I 0.0099
814 Ryanodine receptor 1 RYR1 0.0099
80 Peroxisome proliferator-activated receptor alpha PPARA 0.0097
4081 Vitamin K epoxide reductase complex subunit 1-like protein 1 VKORC1L1 0.0097
604 Vitamin K-dependent protein Z PROZ 0.0097
958 Insulin-like growth factor 1 receptor IGF1R 0.0097
163 D(1B) dopamine receptor DRD5 0.0096
4122 Histone deacetylase 2 HDAC2 0.0095
29 Tubulin beta-1 chain TUBB1 0.0094
6182 Cytochrome P450 2J2 CYP2J2 0.0094
716 5-hydroxytryptamine 7 receptor HTR7 0.0093
232 Corticosteroid-binding globulin SERPINA6 0.0093
147 Aldehyde dehydrogenase, mitochondrial ALDH2 0.0092
6137 Multidrug resistance-associated protein 6 ABCC6 0.0092
818 50S ribosomal protein L10 rplJ 0.0089
228 Beta platelet-derived growth factor receptor PDGFRB 0.0088
523 Gamma-aminobutyric-acid receptor subunit alpha-5 GABRA5 0.0088
422 Vitamin K-dependent protein C PROC 0.0087
1245 Vitamin K-dependent protein S PROS1 0.0087
3804 Sodium channel protein type 4 subunit alpha SCN4A 0.0086
756 Sex hormone-binding globulin SHBG 0.0086
1569 G1/S-specific cyclin-D1 CCND1 0.0085
869 Estrogen receptor beta ESR2 0.0084
4113 Voltage-dependent L-type calcium channel subunit alpha-1F CACNA1F 0.0084
790 DNA polymerase subunit alpha B POLA2 0.0084
1852 Microtubule-associated protein 2 MAP2 0.0081
565 Extracellular calcium-sensing receptor CASR 0.008
3610 Thioredoxin reductase 1, cytoplasmic TXNRD1 0.008
2112 Toll-like receptor 9 TLR9 0.008
798 Osteocalcin BGLAP 0.008
122 P2Y purinoceptor 12 P2RY12 0.008
173 Toll-like receptor 7 TLR7 0.0079
6146 High affinity copper uptake protein 1 SLC31A1 0.0078
762 Voltage-dependent calcium channel subunit alpha-2/delta-1 CACNA2D1 0.0078
1256 5-hydroxytryptamine 6 receptor HTR6 0.0078
448 Vitamin K-dependent gamma-carboxylase GGCX 0.0077
5923 Microtubule-associated protein tau MAPT 0.0077
5924 Microtubule-associated protein 4 MAP4 0.0077
1176 Mitogen-activated protein kinase 1 MAPK1 0.0077
238 Peroxisome proliferator-activated receptor gamma PPARG 0.0076
6141 Sodium/bile acid cotransporter SLC10A1 0.0075
239 Coagulation factor X F10 0.0075
3932 Glutathione S-transferase A2 GSTA2 0.0075
6181 UDP-glucuronosyltransferase 1-8 UGT1A8 0.0074
1971 cAMP-specific 3',5'-cyclic phosphodiesterase 4A PDE4A 0.0074
369 Coagulation factor VII F7 0.0074
6158 Solute carrier organic anion transporter family member 1C1 SLCO1C1 0.0073
530 Gamma-aminobutyric-acid receptor subunit alpha-4 GABRA4 0.0073
4148 Serine/threonine-protein kinase mTOR MTOR 0.0073
4100 Gamma-aminobutyric-acid receptor subunit beta-2 GABRB2 0.0072
17 Proto-oncogene tyrosine-protein kinase ABL1 ABL1 0.0072
841 Gamma-aminobutyric-acid receptor subunit alpha-6 GABRA6 0.0072
1024 Solute carrier family 22 member 11 SLC22A11 0.0071
81 Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial MCCC2 0.007
547 Propionyl-CoA carboxylase alpha chain, mitochondrial PCCA 0.007
495 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial MCCC1 0.007
177 Biotin--protein ligase HLCS 0.007
690 Acetyl-CoA carboxylase 1 ACACA 0.007
610 Calcium-activated potassium channel subunit alpha 1 KCNMA1 0.0069
1638 Solute carrier family 2, facilitated glucose transporter member 2 SLC2A2 0.0069
5251 Carbonyl reductase [NADPH] 1 CBR1 0.0069
1539 Oligopeptide transporter, small intestine isoform SLC15A1 0.0069
1063 Signal transducer and activator of transcription 5B STAT5B 0.0067
935 Proto-oncogene tyrosine-protein kinase Yes YES1 0.0067
105 Sodium-dependent multivitamin transporter SLC5A6 0.0067
1192 Sulfotransferase 1A1 SULT1A1 0.0067
94 5-hydroxytryptamine 4 receptor HTR4 0.0067
2038 Inhibitor of nuclear factor kappa-B kinase subunit beta IKBKB 0.0067
142 Gamma-aminobutyric-acid receptor subunit rho-1 GABRR1 0.0067
124 Histamine H2 receptor HRH2 0.0066
4095 Neuronal acetylcholine receptor subunit alpha-7 CHRNA7 0.0065
947 Neuronal acetylcholine receptor subunit alpha-4 CHRNA4 0.0065
606 Cytochrome P450 27, mitochondrial CYP27A1 0.0065
6043 Putative G-protein coupled receptor 44 GPR44 0.0065
706 Glutamate [NMDA] receptor subunit 3A GRIN3A 0.0065
476 RAC-alpha serine/threonine-protein kinase AKT1 0.0065
3917 Methylenetetrahydrofolate reductase MTHFR 0.0064
1820 Beta-nerve growth factor NGF 0.0064
631 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR 0.0064
3387 3-hydroxy-3-methylglutaryl-coenzyme A reductase mvaA 0.0064
6068 Guanylate cyclase soluble subunit alpha-2 GUCY1A2 0.0063
268 Adenosine A2b receptor ADORA2B 0.0063
714 Glutathione reductase, mitochondrial GSR 0.0063
1502 Peroxisome proliferator-activated receptor delta PPARD 0.0062
33 Cystine/glutamate transporter SLC7A11 0.0061
952 Dipeptidyl peptidase 4 DPP4 0.0061
737 Mineralocorticoid receptor NR3C2 0.0061
1995 Sodium channel protein type 9 subunit alpha SCN9A 0.0061
6040 6-phosphogluconate dehydrogenase, decarboxylating PGD 0.0061
904 Glutathione S-transferase P GSTP1 0.006
68 Cannabinoid receptor 1 CNR1 0.006
5934 Cytochrome P450 26A1 CYP26A1 0.006
601 Propionyl-CoA carboxylase beta chain, mitochondrial PCCB 0.006
820 Glycine receptor subunit alpha-2 GLRA2 0.0059
4192 DNA topoisomerase 2-beta TOP2B 0.0059
3957 Adenosine deaminase ADA 0.0059
131 Synaptic vesicular amine transporter SLC18A2 0.0059
161 Tubulin beta chain TUBB 0.0058
312 Tubulin beta chain TUB2 0.0058
934 Proto-oncogene tyrosine-protein kinase Fyn FYN 0.0058
6766 O-GlcNAcase BT_4395 BT_4395 0.0058
1656 CYP2B protein CYP2B 0.0057
936 Ephrin type-A receptor 2 EPHA2 0.0057
771 Pyruvate carboxylase, mitochondrial PC 0.0056
528 5-hydroxytryptamine 1E receptor HTR1E 0.0056
4311 tRNA TRDMT1 0.0056
4325 tRNA trmD 0.0056
4328 tRNA trmD 0.0056
295 Carbonic anhydrase 1 CA1 0.0055
6102 Arylamine N-acetyltransferase 2 NAT2 0.0055
6506 Stathmin-4 STMN4 0.0055
84 Nuclear receptor 0B1 NR0B1 0.0055
4160 Voltage-dependent calcium channel subunit alpha-2/delta-2 CACNA2D2 0.0055
462 Intermediate conductance calcium-activated potassium channel protein 4 KCNN4 0.0054
484 Tyrosine-protein kinase ABL2 ABL2 0.0054
856 Vitamin D3 receptor VDR 0.0054
3802 Sodium channel protein type 2 subunit alpha SCN2A 0.0054
650 Aldo-keto reductase family 1 member C3 AKR1C3 0.0053
5998 Toll-like receptor 8 TLR8 0.0053
6023 Cytochrome P450 11B2, mitochondrial CYP11B2 0.0053
6339 Ig kappa chain V-II region RPMI 6410 Not Available 0.0052
407 Vascular endothelial growth factor receptor 2 KDR 0.0052
712 Tubulin alpha chain TUB1 0.0052
259 Microsomal triglyceride transfer protein large subunit MTTP 0.0052
775 Acetyl-CoA carboxylase 2 ACACB 0.0052
6177 UDP-glucuronosyltransferase 1-10 UGT1A10 0.0052
908 Glutathione S-transferase theta-1 GSTT1 0.0052
620 Bifunctional dihydrofolate reductase-thymidylate synthase Not Available 0.0051
4199 Sphingosine 1-phosphate receptor Edg-8 S1PR5 0.005
26 Vascular endothelial growth factor receptor 3 FLT4 0.0049
3937 Fatty-acid amide hydrolase FAAH 0.0048
6163 Copper-transporting ATPase 2 ATP7B 0.0048
6165 Copper-transporting ATPase 1 ATP7A 0.0048
6079 Neuronal acetylcholine receptor subunit alpha-3 CHRNA3 0.0048
284 DNA-directed RNA polymerase beta chain rpoB 0.0048
5773 DNA-directed RNA polymerase beta chain rpoB 0.0048
1050 Bile salt sulfotransferase SULT2A1 0.0047
937 Proto-oncogene tyrosine-protein kinase LCK LCK 0.0047
32 Vascular endothelial growth factor receptor 1 FLT1 0.0047
592 Carbonic anhydrase 4 CA4 0.0047
918 Glutamate receptor, ionotropic kainate 2 GRIK2 0.0047
511 5-hydroxytryptamine 1F receptor HTR1F 0.0046
365 Dihydrofolate reductase DHFR 0.0046
2381 Dihydrofolate reductase DFR1 0.0046
2833 Dihydrofolate reductase Not Available 0.0046
2931 Dihydrofolate reductase folA 0.0046
3544 Dihydrofolate reductase folA 0.0046
3682 Dihydrofolate reductase folA 0.0046
6642 Dihydrofolate reductase folA 0.0046
6756 Dihydrofolate reductase dfrA 0.0046
896 Glutathione S-transferase Mu 1 GSTM1 0.0046
7 Nitric oxide synthase, inducible NOS2 0.0046
464 Glutamate [NMDA] receptor subunit epsilon-2 GRIN2B 0.0046
4237 50S ribosomal protein L22 rplV 0.0046
70 Type-1 angiotensin II receptor AGTR1 0.0045
1787 Nuclear factor NF-kappa-B p105 subunit NFKB1 0.0045
698 B-Raf proto-oncogene serine/threonine-protein kinase BRAF 0.0045
6087 Gamma-aminobutyric acid receptor subunit gamma-1 GABRG1 0.0044
6093 Gamma-aminobutyric acid receptor subunit delta GABRD 0.0044
6089 Gamma-aminobutyric acid receptor subunit epsilon GABRE 0.0044
4152 Superoxide dismutase [Cu-Zn] SOD1 0.0044
750 Voltage-dependent calcium channel gamma-1 subunit CACNG1 0.0044
522 26S proteasome non-ATPase regulatory subunit 2 PSMD2 0.0044
515 26S proteasome non-ATPase regulatory subunit 1 PSMD1 0.0044
6150 Solute carrier organic anion transporter family member 4C1 SLCO4C1 0.0044
482 Glycine receptor subunit alpha-1 GLRA1 0.0043
4098 Gamma-aminobutyric-acid receptor subunit beta-1 GABRB1 0.0043
6136 Multidrug resistance-associated protein 5 ABCC5 0.0043
461 Glycine receptor subunit alpha-3 GLRA3 0.0043
921 Glutamate receptor 2 GRIA2 0.0043
858 Potassium voltage-gated channel subfamily A member 1 KCNA1 0.0043
164 Histamine H4 receptor HRH4 0.0042
6038 Retinal cone rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6H 0.0042
811 Translocator protein TSPO 0.0042
6045 Voltage-dependent calcium channel subunit alpha-2/delta-3 CACNA2D3 0.0042
469 Annexin A1 ANXA1 0.0041
581 Cytochrome P450 2R1 CYP2R1 0.0041
4112 Voltage-dependent L-type calcium channel subunit beta-4 CACNB4 0.0041
4114 Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 0.0041
933 Proto-oncogene tyrosine-protein kinase Src SRC 0.0041
6086 Gamma-aminobutyric acid receptor subunit gamma-2 GABRG2 0.0041
3997 Cytochrome P450 24A1, mitochondrial CYP24A1 0.0041
6090 Gamma-aminobutyric acid receptor subunit pi GABRP 0.004
6092 Gamma-aminobutyric acid receptor subunit rho-2 GABRR2 0.004
6088 Gamma-aminobutyric acid receptor subunit gamma-3 GABRG3 0.004
6115 Gamma-aminobutyric acid receptor subunit rho-3 GABRR3 0.004
73 Prostaglandin E2 receptor, EP1 subtype PTGER1 0.004
6153 Solute carrier organic anion transporter family member 4A1 SLCO4A1 0.004
823 Fibroblast growth factor receptor 2 FGFR2 0.004
6032 PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) fas 0.004
813 Neuronal acetylcholine receptor subunit alpha-2 CHRNA2 0.004
6037 Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma PDE6G 0.004
3426 Glutamine synthetase glnA 0.0039
3987 Glutamine synthetase GLUL 0.0039
360 Ribonucleoside-diphosphate reductase large subunit RRM1 0.0039
4146 Phosphatidylinositol 3-kinase regulatory subunit gamma PIK3R3 0.0039
4145 Phosphatidylinositol 3-kinase regulatory subunit beta PIK3R2 0.0039
1129 C-C chemokine receptor type 5 CCR5 0.0039
734 D1 dopamine receptor-interacting protein calcyon CALY 0.0039
275 Arachidonate 5-lipoxygenase ALOX5 0.0038
950 Alpha platelet-derived growth factor receptor PDGFRA 0.0038
194 NADH dehydrogenase [ubiquinone] 1 subunit C2 NDUFC2 0.0038
333 Voltage-dependent L-type calcium channel subunit beta-1 CACNB1 0.0037
891 Dihydropteroate synthase folP 0.0037
5359 Dihydropteroate synthase folP 0.0037
7175 Dihydropteroate synthase sulI 0.0037
806 Sodium/potassium-transporting ATPase alpha-1 chain ATP1A1 0.0037
337 NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial NDUFS7 0.0037
214 NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial NDUFS3 0.0037
803 NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial NDUFS2 0.0037
705 Glutamate receptor 1 GRIA1 0.0037
327 Glutathione reductase gor 0.0036
5110 Glutathione reductase GR2 0.0036
6044 Serum paraoxonase/lactonase 3 PON3 0.0036
634 Squalene monooxygenase SQLE 0.0036
7196 Squalene monooxygenase ERG1 0.0036
458 Neuronal acetylcholine receptor subunit alpha-10 CHRNA10 0.0036
6861 Alcohol dehydrogenase [NADP+] AKR1A1 0.0036
543 Penicillin-binding protein 1B mrcB 0.0035
6186 Penicillin-binding protein 1B ponB 0.0035
6822 Penicillin-binding protein 1b pbp1b 0.0035
6844 Penicillin-binding protein 1b pbp1b 0.0035
158 Sodium channel protein type 1 subunit alpha SCN1A 0.0035
976 Platelet glycoprotein IX GP9 0.0035
185 Vasopressin V1a receptor AVPR1A 0.0035
778 Cysteinyl leukotriene receptor 1 CYSLTR1 0.0035
357 Carbonic anhydrase 2 CA2 0.0035
117 Sterol O-acyltransferase 1 SOAT1 0.0035
569 Retinal dehydrogenase 2 ALDH1A2 0.0035
159 Penicillin-binding protein 2B penA 0.0035
6121 Penicillin-binding protein 2B penA 0.0035
1374 Natriuretic peptides B NPPB 0.0035
939 50S ribosomal protein L3 rplC 0.0035
1827 Gap junction alpha-1 protein GJA1 0.0035
1908 Vascular cell adhesion protein 1 VCAM1 0.0035
6432 Transporter snf 0.0035
322 Vasopressin V2 receptor AVPR2 0.0034
4103 Proteasome subunit beta type 2 PSMB2 0.0034
4102 Proteasome subunit beta type 5 PSMB5 0.0034
4101 Proteasome subunit beta type 1 PSMB1 0.0034
6172 ATP-binding cassette sub-family B member 8, mitochondrial ABCB8 0.0034
514 Potassium voltage-gated channel subfamily H member 6 KCNH6 0.0034
772 Potassium voltage-gated channel subfamily H member 7 KCNH7 0.0034
596 3-oxo-5-alpha-steroid 4-dehydrogenase 1 SRD5A1 0.0033
1281 Phosphatidylinositol 3-kinase regulatory subunit alpha PIK3R1 0.0033
251 Alcohol dehydrogenase 1A ADH1A 0.0033
6078 Neuronal acetylcholine receptor subunit beta-4 CHRNB4 0.0033
611 Retinal dehydrogenase 1 ALDH1A1 0.0033
6180 UDP-glucuronosyltransferase 2B4 UGT2B4 0.0033
106 Cannabinoid receptor 2 CNR2 0.0033
6085 Fatty acid-binding protein, intestinal FABP2 0.0033
6091 Gamma-aminobutyric acid receptor subunit theta GABRQ 0.0032
183 Vascular endothelial growth factor A VEGFA 0.0032
780 Retinoic acid receptor RXR-gamma RXRG 0.0032
140 30S ribosomal protein S9 rpsI 0.0031
6719 30S ribosomal protein S9 rpsI 0.0031
6725 30S ribosomal protein S9 rpsI 0.0031
276 Sodium- and chloride-dependent GABA transporter 1 SLC6A1 0.0031
6206 DNA-directed RNA polymerase subunit beta' rpoC 0.0031
1636 Trace amine-associated receptor 1 TAAR1 0.0031
6046 Voltage-gated calcium channel beta 1 subunit splice variant CavB1d CACNB1 0.0031
76 Nitric-oxide synthase, brain NOS1 0.0031
4177 Proto-oncogene tyrosine-protein kinase receptor ret RET 0.0031
427 Substance-P receptor TACR1 0.0031
2268 Cholesterol oxidase choB 0.0031
2822 Cholesterol oxidase choA 0.0031
200 Carnitine O-palmitoyltransferase 2, mitochondrial CPT2 0.0031
451 Carnitine O-palmitoyltransferase I, liver isoform CPT1A 0.0031
6126 Carbonic anhydrase 7 CA7 0.003
2578 Tubulin beta-3 chain TUBB3 0.003
2285 Streptogramin A acetyltransferase vatD 0.003
2222 Equilibrative nucleoside transporter 1 SLC29A1 0.003
444 Alcohol dehydrogenase 1B ADH1B 0.003
1457 Long-chain-fatty-acid--CoA ligase 4 ACSL4 0.003
6080 Neuronal acetylcholine receptor subunit alpha-5 CHRNA5 0.003
6082 Neuronal acetylcholine receptor subunit beta-3 CHRNB3 0.003
948 Neuronal acetylcholine receptor subunit beta-2 CHRNB2 0.003
741 Potassium voltage-gated channel subfamily KQT member 1 KCNQ1 0.003
822 Aldose reductase AKR1B1 0.0029
4238 50S ribosomal protein L4 rplD 0.0029
5578 50S ribosomal protein L4 rplD 0.0029
6173 50S ribosomal protein L4 rplD 0.0029
6219 50S ribosomal protein L4 rplD 0.0029
1992 Vitamin D-binding protein GC 0.0029
559 NADH-ubiquinone oxidoreductase chain 1 MT-ND1 0.0029
88 Retinoic acid receptor RXR-beta RXRB 0.0029
178 NADH-cytochrome b5 reductase 3 CYB5R3 0.0029
812 Dihydrolipoyl dehydrogenase, mitochondrial DLD 0.0029
512 DNA-directed RNA polymerase alpha chain rpoA 0.0029
5772 DNA-directed RNA polymerase alpha chain rpoA 0.0029
992 Protein tyrosine kinase 2 beta PTK2B 0.0028
6168 Solute carrier family 22 member 16 SLC22A16 0.0028
518 Peroxidase/catalase T katG 0.0028
473 L-lactate dehydrogenase A chain LDHA 0.0028
3970 Voltage-dependent N-type calcium channel subunit alpha-1B CACNA1B 0.0028
839 Short-chain specific acyl-CoA dehydrogenase, mitochondrial ACADS 0.0028
6081 Neuronal acetylcholine receptor subunit alpha-6 CHRNA6 0.0028
723 Cytosolic phospholipase A2 PLA2G4A 0.0027
4097 Neuronal acetylcholine receptor subunit alpha-9 CHRNA9 0.0027
230 ATP-binding cassette transporter sub-family C member 8 ABCC8 0.0027
4173 Tyrosine-protein kinase JAK2 JAK2 0.0027
3856 Fibroblast growth factor receptor 3 FGFR3 0.0027
6152 Solute carrier organic anion transporter family member 2A1 SLCO2A1 0.0027
3849 Insulin-like growth factor-binding protein 7 IGFBP7 0.0027
2009 Protein NOV homolog NOV 0.0027
3847 Neuroendocrine convertase 2 PCSK2 0.0027
1949 Carboxypeptidase E CPE 0.0027
3850 Synaptotagmin-like protein 4 SYTL4 0.0027
3848 Neuroendocrine convertase 1 PCSK1 0.0027
3846 Retinoblastoma-associated protein RB1 0.0027
392 Voltage-dependent P/Q-type calcium channel subunit alpha-1A CACNA1A 0.0026
567 Receptor tyrosine-protein kinase erbB-2 ERBB2 0.0026
517 Alcohol dehydrogenase 1C ADH1C 0.0026
563 Thyroid peroxidase TPO 0.0026
1648 Elastin ELN 0.0026
49 Endothelin B receptor EDNRB 0.0026
1974 Oligopeptide transporter, kidney isoform SLC15A2 0.0025
5880 Thrombopoietin receptor MPL 0.0025
241 Calcium-transporting ATPase type 2C member 1 ATP2C1 0.0025
390 Adenosine A3 receptor ADORA3 0.0025
768 FK506-binding protein 1A FKBP1A 0.0025
5095 Putidaredoxin reductase camA 0.0025
526 Thioredoxin reductase trxB 0.0025
3767 Thioredoxin reductase trxB 0.0025
5107 Alkyl hydroperoxide reductase subunit F ahpF 0.0025
5118 Alkyl hydroperoxide reductase subunit F ahpF 0.0025
5122 Mersacidin decarboxylase mrsD 0.0025
5112 Benzoate 1,2-dioxygenase electron transfer component benC 0.0025
5115 FkbI fkbI 0.0025
3133 UDP-galactopyranose mutase glf 0.0025
5099 UDP-galactopyranose mutase glf 0.0025
5114 Putative acyl-CoA dehydrogenase TT_C0779 0.0025
5083 Cryptochrome DASH cry 0.0025
5097 PROBABLE DIHYDROLIPOAMIDE DEHYDROGENASE LPDA lpdA 0.0025
3763 5,10-methylenetetrahydrofolate reductase metF 0.0025
3918 5,10-methylenetetrahydrofolate reductase MTHFR 0.0025
5094 5,10-methylenetetrahydrofolate reductase metF 0.0025
5078 Amine oxidase, flavin-containing PSPTO1126 0.0025
1329 Apoptosis-inducing factor 1, mitochondrial AIFM1 0.0025
5100 Gamma-aminobutyrate metabolism dehydratase/isomerase abfD 0.0025
5102 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit pchF 0.0025
5081 L-aspartate oxidase nadB 0.0025
5111 Phenylacetone monooxygenase pamO 0.0025
1410 Oxidoreductase HSD17B6 0.0025
4725 Oxidoreductase Not Available 0.0025
5124 Oxidoreductase Not Available 0.0025
5109 Outer membrane protein p64k or PM-6 m-6 0.0025
6154 Multidrug and toxin extrusion protein 1 SLC47A1 0.0024
6123 Carbonic anhydrase 5A, mitochondrial CA5A 0.0024
1275 Estrogen sulfotransferase SULT1E1 0.0024
578 Endothelin-1 receptor EDNRA 0.0024
544 Potassium voltage-gated channel subfamily E member 1 KCNE1 0.0024
564 Cellular retinoic acid-binding protein 1 CRABP1 0.0024
1483 Membrane copper amine oxidase AOC3 0.0024
6039 Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A PDE11A 0.0024
738 Monocarboxylate transporter 1 SLC16A1 0.0024
537 ATP synthase delta chain, mitochondrial ATP5D 0.0024
6070 Nischarin NISCH 0.0024
233 Potassium channel subfamily K member 2 KCNK2 0.0024
5852 Type-2 angiotensin II receptor AGTR2 0.0024
174 Sigma 1-type opioid receptor SIGMAR1 0.0024
1561 Troponin C, slow skeletal and cardiac muscles TNNC1 0.0023
642 3-oxo-5-alpha-steroid 4-dehydrogenase 2 SRD5A2 0.0023
3086 Plasmepsin-2 Not Available 0.0023
550 Amiloride-sensitive sodium channel subunit delta SCNN1D 0.0023
27 Amiloride-sensitive sodium channel subunit beta SCNN1B 0.0023
552 Amiloride-sensitive sodium channel subunit gamma SCNN1G 0.0023
213 Amiloride-sensitive sodium channel subunit alpha SCNN1A 0.0023
1830 5'-nucleotidase NT5E 0.0023
837 Glutamate [NMDA] receptor subunit epsilon-1 GRIN2A 0.0023
859 Cellular retinoic acid-binding protein 2 CRABP2 0.0023
751 Potassium channel subfamily K member 6 KCNK6 0.0023
4486 Phenol 2-hydroxylase component B pheA2 0.0023
4477 Dihydrolipoyl dehydrogenase lpdV 0.0023
5077 Dihydrolipoyl dehydrogenase Not Available 0.0023
5117 Dihydrolipoyl dehydrogenase lpd 0.0023
4439 Ferredoxin reductase bphA4 0.0023
291 Nitric-oxide synthase, endothelial NOS3 0.0022
208 DNA-directed RNA polymerase beta' chain rpoC 0.0022
5774 DNA-directed RNA polymerase beta' chain rpoC 0.0022
990 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 0.0022
6098 Potassium voltage-gated channel subfamily D member 2 KCND2 0.0022
6099 Potassium voltage-gated channel subfamily D member 3 KCND3 0.0022
6131 Carbonic anhydrase 14 CA14 0.0022
6047 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A PDE1A 0.0022
3404 Exotoxin A eta 0.0022
1086 Potassium voltage-gated channel subfamily KQT member 2 KCNQ2 0.0022
2155 Insulin-degrading enzyme IDE 0.0022
165 FL cytokine receptor FLT3 0.0021
298 Renin REN 0.0021
5075 Sulfite reductase [NADPH] flavoprotein alpha-component cysJ 0.0021
5073 Ferredoxin--NADP reductase petH 0.0021
5076 Ferredoxin--NADP reductase fpr 0.0021
5119 Ferredoxin--NADP reductase petH 0.0021
5121 Ferredoxin--NADP reductase fpr 0.0021
2526 NADPH-ferredoxin reductase fprA fprA 0.0021
440 Isovaleryl-CoA dehydrogenase, mitochondrial IVD 0.0021
5091 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0021
5093 UDP-N-acetylenolpyruvoylglucosamine reductase murB 0.0021
667 Acyl-CoA dehydrogenase family member 8, mitochondrial ACAD8 0.0021
5003 Acyl-CoA dehydrogenase, short-chain specific Not Available 0.0021
3594 Deoxyribodipyrimidine photo-lyase phr 0.0021
5079 Deoxyribodipyrimidine photo-lyase phrB 0.0021
5080 Deoxyribodipyrimidine photo-lyase phr 0.0021
3506 Glutaryl-CoA dehydrogenase, mitochondrial GCDH 0.0021
2091 Endoplasmin HSP90B1 0.0021
5072 N,N-dimethylglycine oxidase dmg 0.0021
1618 High affinity nerve growth factor receptor NTRK1 0.0021
2470 Pyruvate oxidase pox5 0.0021
6639 Peroxisomal acyl-coenzyme A oxidase 1 ACOX1 0.0021
3247 2-oxopropyl-CoM reductase, carboxylating xecC 0.0021
1244 Low-density lipoprotein receptor-related protein 2 LRP2 0.0021
3102 Flavohemoprotein hmp 0.0021
4969 Flavohemoprotein hmp 0.0021
172 Potassium channel subfamily K member 1 KCNK1 0.0021
2539 Tubulin alpha-1 chain TUBA4A 0.0021
63 Malate dehydrogenase mdh 0.0021
2329 Malate dehydrogenase mdh 0.0021
3445 Malate dehydrogenase mdh 0.0021
4420 Malate dehydrogenase mdh 0.0021
4438 Malate dehydrogenase mdh 0.0021
5692 Calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1B PDE1B 0.0021
4440 NADH peroxidase npr 0.002
6122 Carbonic anhydrase 3 CA3 0.002
3185 Medium-chain specific acyl-CoA dehydrogenase, mitochondrial ACADM 0.002
1302 Dihydropyrimidine dehydrogenase [NADP+] DPYD 0.002
162 Retinoic acid receptor gamma-1 RARG 0.0019
633 Penicillin-binding proteins 1A/1B pbpA 0.0019
2893 Glycine oxidase thiO 0.0019
627 11-cis retinol dehydrogenase RDH5 0.0019
640 Aldehyde dehydrogenase 1A3 ALDH1A3 0.0019
3254 Bifunctional protein putA [Includes: Proline dehydrogenase putA 0.0019
6164 POU domain, class 5, transcription factor 1 POU5F1 0.0019
5766 NAD-dependent deacetylase sirtuin-5 SIRT5 0.0019
40 RAF proto-oncogene serine/threonine-protein kinase RAF1 0.0019
368 Enoyl-[acyl-carrier-protein] reductase [NADH] inhA 0.0019
3228 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0019
3678 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0019
6856 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI 0.0019
3573 2,4-dienoyl-CoA reductase [NADPH] fadH 0.0019
2567 Thymidylate synthase thyX thyX 0.0019
153 Dopamine beta-hydroxylase DBH 0.0018
2823 Trypanothione reductase TPR 0.0018
893 [Citrate [pro-3S]-lyase] ligase citC 0.0018
126 D-lactate dehydrogenase dld 0.0018
3545 D-lactate dehydrogenase Not Available 0.0018
4510 D-lactate dehydrogenase ldhA 0.0018
845 Pyruvate dehydrogenase [cytochrome] poxB 0.0018
66 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type II HSD3B2 0.0018
3854 Basic fibroblast growth factor receptor 1 FGFR1 0.0018
1968 ATP-sensitive inward rectifier potassium channel 12 KCNJ12 0.0018
2769 P-hydroxybenzoate hydroxylase pobA 0.0018
2809 P-hydroxybenzoate hydroxylase pobA 0.0018
683 Potassium transporter GK0582 0.0018
748 5'-AMP-activated protein kinase catalytic subunit alpha-1 PRKAA1 0.0018
770 Retinoic acid-induced protein 3 GPRC5A 0.0018
719 Retinoic acid receptor responder protein 1 RARRES1 0.0018
459 Retinoic acid receptor RXR-alpha RXRA 0.0018
67 Prolyl 4-hydroxylase subunit alpha-1 P4HA1 0.0017
621 Periplasmic [Fe] hydrogenase 1 Not Available 0.0017
2450 Tyrosine-protein kinase ITK/TSK ITK 0.0017
2290 ADP-ribosyl cyclase 2 BST1 0.0017
439 Glutamate [NMDA] receptor subunit epsilon-4 GRIN2D 0.0017
2380 Monomeric sarcosine oxidase soxA 0.0017
144 Hemoglobin subunit alpha HBA1 0.0016
4209 ATP-sensitive inward rectifier potassium channel 8 KCNJ8 0.0016
4773 Deoxycytidine kinase DCK 0.0016
6645 D-amino-acid oxidase DAO 0.0016
1243 Cathepsin D CTSD 0.0016
102 DNA topoisomerase I, mitochondrial TOP1MT 0.0016
3810 Catechol O-methyltransferase COMT 0.0016
389 Amiloride-sensitive cation channel 2, neuronal ACCN2 0.0016
267 Plasminogen activator inhibitor 1 SERPINE1 0.0015
3233 Bile acid receptor NR1H4 0.0015
401 Glutamate [NMDA] receptor subunit zeta-1 GRIN1 0.0015
6124 Carbonic anhydrase 5B, mitochondrial CA5B 0.0015
5787 Angiopoietin-1 receptor TEK 0.0015
3126 Poly [ADP-ribose] polymerase 1 PARP1 0.0015
6138 Multidrug resistance protein 3 ABCB4 0.0015
982 Cocaine- and amphetamine-regulated transcript protein CARTPT 0.0015
217 Estradiol 17-beta-dehydrogenase 1 HSD17B1 0.0015
4162 Potassium voltage-gated channel subfamily KQT member 3 KCNQ3 0.0015
3809 Estrogen-related receptor gamma ESRRG 0.0015
828 Phenylalanine-4-hydroxylase PAH 0.0015
3109 Phenylalanine-4-hydroxylase phhA 0.0015
3844 HLA class II histocompatibility antigen, DQ(6) alpha chain HLA-DQA2 0.0015
1939 Heat shock protein HSP 90-alpha HSP90AA1 0.0015
182 2-oxoglutarate dehydrogenase E1 component, mitochondrial OGDH 0.0015
6824 Tyrosine-protein kinase Lyn LYN 0.0014
1541 Metalloproteinase mmp20 0.0014
951 Macrophage colony-stimulating factor 1 receptor CSF1R 0.0014
6167 Organic solute transporter subunit beta OSTB 0.0014
6166 Organic solute transporter subunit alpha OSTA 0.0014
6221 Steroid hormone receptor ERR1 ESRRA 0.0014
1341 Histamine H3 receptor HRH3 0.0014
1262 Corticotropin-lipotropin POMC 0.0014
6179 UDP-glucuronosyltransferase 2B17 UGT2B17 0.0014
6859 Protein S100-A4 S100A4 0.0014
2184 Cystic fibrosis transmembrane conductance regulator CFTR 0.0013
364 Corticosteroid 11-beta-dehydrogenase isozyme 1 HSD11B1 0.0013
1864 RET proto-oncogene RET 0.0013
1353 DNA topoisomerase 1 TOP1 0.0013
3552 DNA topoisomerase 1 topA 0.0013
1950 Epithelial discoidin domain-containing receptor 1 DDR1 0.0013
6094 BCR/ABL fusion protein isoform X9 BCR/ABL fusion 0.0013
6170 ATP-binding cassette sub-family A member 3 ABCA3 0.0013
244 Angiotensin-converting enzyme ACE 0.0013
561 Retinol-binding protein II, cellular RBP2 0.0013
35 Dehydrogenase/reductase SDR family member 4 DHRS4 0.0013
4073 Retinol dehydrogenase 11 RDH11 0.0013
4074 Retinol dehydrogenase 14 RDH14 0.0013
1097 Lecithin retinol acyltransferase LRAT 0.0013
589 Retinoid-binding protein 7 RBP7 0.0013
753 Retinol-binding protein III, cellular RBP5 0.0013
4071 Short-chain dehydrogenase/reductase 3 DHRS3 0.0013
4075 Photoreceptor outer segment all-trans retinol dehydrogenase RDH8 0.0013
863 Cellular retinaldehyde-binding protein RLBP1 0.0013
800 Retinol dehydrogenase 12 RDH12 0.0013
282 Interphotoreceptor retinoid-binding protein RBP3 0.0013
651 Retinol dehydrogenase 13 RDH13 0.0013
4072 All-trans-retinol 13,14-reductase RETSAT 0.0013
2180 3-phosphoinositide-dependent protein kinase 1 PDPK1 0.0013
6211 Tubulin epsilon chain TUBE1 0.0013
6212 Tubulin gamma-1 chain TUBG1 0.0013
6210 Tubulin delta chain TUBD1 0.0013
215 Sodium channel protein type 11 subunit alpha SCN11A 0.0013
170 Succinate semialdehyde dehydrogenase, mitochondrial ALDH5A1 0.0013
3007 Carbonic anhydrase 12 CA12 0.0013
4205 Carbonic anhydrase 9 CA9 0.0013
860 Nicotinamide N-methyltransferase NNMT 0.0013
5626 Nucleoside diphosphate kinase B NME2 0.0013
699 Nicotinic acid receptor 1 GPR109A 0.0013
928 Nicotinic acid receptor 2 GPR109B 0.0013
583 Nicotinate-nucleotide pyrophosphorylase [carboxylating] QPRT 0.0013
2442 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
2459 Nicotinate-nucleotide pyrophosphorylase [carboxylating] nadC 0.0013
424 Dihydroorotate dehydrogenase, mitochondrial DHODH 0.0013
6116 Gastric triacylglycerol lipase LIPF 0.0012
6933 Calcium-activated potassium channel subunit beta-4 KCNMB4 0.0012
6931 Calcium-activated potassium channel subunit beta-1 KCNMB1 0.0012
6932 Calcium-activated potassium channel subunit beta-3 KCNMB3 0.0012
6934 Small conductance calcium-activated potassium channel protein 1 KCNN1 0.0012
6935 Small conductance calcium-activated potassium channel protein 2 KCNN2 0.0012
6936 Small conductance calcium-activated potassium channel protein 3 KCNN3 0.0012
760 Fibroblast growth factor 1 FGF1 0.0012
3806 cGMP-dependent 3',5'-cyclic phosphodiesterase PDE2A 0.0012
3823 Cytokine receptor common gamma chain IL2RG 0.0012
85 Growth hormone receptor GHR 0.0012
2107 Microtubule-associated protein 1A MAP1A 0.0012
338 DNA polymerase UL30 0.0012
379 DNA polymerase UL54 0.0012
697 DNA polymerase ORF28 0.0012
2482 DNA polymerase 43 0.0012
4104 DNA polymerase BALF5 0.0012
997 Protein kinase C beta type PRKCB 0.0012
1295 Fatty acid synthase FASN 0.0012
331 Retinol-binding protein I, cellular RBP1 0.0012
5878 Alpha-7 nicotinic cholinergic receptor subunit CHRFAM7A 0.0012
505 Glutamate [NMDA] receptor subunit epsilon-3 GRIN2C 0.0011
2981 Phospholipase A2, membrane associated PLA2G2A 0.0011
1360 Sphingomyelin phosphodiesterase SMPD1 0.0011
1970 Protein kinase C alpha type PRKCA 0.0011
754 Pancreatic triacylglycerol lipase PNLIP 0.0011
319 Opioid receptor, sigma 1 OPRS1 0.0011
796 Inosine-5'-monophosphate dehydrogenase 2 IMPDH2 0.0011
707 72 kDa type IV collagenase MMP2 0.0011
5463 Calcium-activated potassium channel subunit beta 2 KCNMB2 0.0011
2408 Tyrosine-protein kinase SYK SYK 0.0011
816 Biliverdin reductase A BLVRA 0.0011
579 Alcohol dehydrogenase class 4 mu/sigma chain ADH7 0.0011
792 Aldehyde dehydrogenase, dimeric NADP-preferring ALDH3A1 0.0011
316 4-trimethylaminobutyraldehyde dehydrogenase ALDH9A1 0.0011
2178 Metabotropic glutamate receptor 5 GRM5 0.0011
724 Interleukin-2 receptor alpha chain IL2RA 0.0011
717 Interleukin-2 receptor subunit beta IL2RB 0.0011
838 Inosine-5'-monophosphate dehydrogenase 1 IMPDH1 0.001
2300 Lysozyme E 0.001
3633 Lysozyme R 0.001
5597 Lysozyme 17 0.001
1630 Integrin beta-2 ITGB2 0.001
591 Glutamate [NMDA] receptor subunit 3B GRIN3B 0.001
1810 Protein S100-A1 S100A1 0.001
6097 Protein S100-A2 S100A2 0.001
4116 Dihydropteroate synthetase Not Available 0.001
1144 Hepatocyte growth factor receptor MET 0.001
646 Malate dehydrogenase, cytoplasmic MDH1 0.001
350 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 0.001
493 25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial CYP27B1 0.001
454 Peroxisomal multifunctional enzyme type 2 HSD17B4 0.001
5294 Nucleoside diphosphate kinase A NME1 0.001
328 Sorbitol dehydrogenase SORD 0.001
635 Estradiol 17-beta-dehydrogenase 8 HSD17B8 0.001
666 NADP-dependent malic enzyme ME1 0.001
597 Dihydropteridine reductase QDPR 0.001
695 cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A PDE10A 0.001
363 NADP-dependent malic enzyme, mitochondrial ME3 0.001
396 Alcohol dehydrogenase 4 ADH4 0.001
2216 Fibroblast growth factor receptor 4 FGFR4 0.001
245 Large neutral amino acids transporter small subunit 1 SLC7A5 0.001
345 Plasma retinol-binding protein RBP4 0.001
5300 Antigen peptide transporter 1 TAP1 0.001
6100 BDNF/NT-3 growth factors receptor NTRK2 0.001
4041 Microsomal glutathione S-transferase 2 MGST2 0.001
857 Malate dehydrogenase, mitochondrial MDH2 0.001
446 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 NDUFA7 0.001
300 NADH-ubiquinone oxidoreductase chain 4L MT-ND4L 0.001
374 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 NDUFB1 0.001
219 NADH-ubiquinone oxidoreductase chain 3 MT-ND3 0.001
104 NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial NDUFS6 0.001
247 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 NDUFA1 0.001
236 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 NDUFA6 0.001
343 NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial NDUFC1 0.001
190 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4 NDUFA4 0.001
755 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 0.001
353 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 4-like 2 NDUFA4L2 0.001
602 Acyl carrier protein, mitochondrial NDUFAB1 0.001
313 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 NDUFB3 0.001
384 NADH-ubiquinone oxidoreductase chain 6 MT-ND6 0.001
607 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 NDUFA2 0.001
555 NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial NDUFS4 0.001
475 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial NDUFB2 0.001
99 NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 NDUFS5 0.001
270 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial NDUFB5 0.001
30 NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial NDUFV3 0.001
525 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 NDUFA5 0.001
41 NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial NDUFS8 0.001
417 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 NDUFB6 0.001
324 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 NDUFB4 0.001
568 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 NDUFB7 0.001
598 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 NDUFA11 0.001
152 NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial NDUFV2 0.001
582 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 NDUFA13 0.001
829 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 NDUFA12 0.001
107 C-4 methylsterol oxidase SC4MOL 0.001
405 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 NDUFA8 0.001
272 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 NDUFB10 0.001
372 Estradiol 17-beta-dehydrogenase 3 HSD17B3 0.001
711 UDP-glucose 6-dehydrogenase UGDH 0.001
3672 UDP-glucose 6-dehydrogenase hasB 0.001
656 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 NDUFB9 0.001
746 NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial NDUFB8 0.001
167 L-lactate dehydrogenase C chain LDHC 0.001
326 L-lactate dehydrogenase A-like 6A LDHAL6A 0.001
141 3-hydroxyisobutyrate dehydrogenase, mitochondrial HIBADH 0.001
206 3-keto-steroid reductase HSD17B7 0.001
721 NADH-ubiquinone oxidoreductase chain 2 MT-ND2 0.001
231 Glycerol-3-phosphate dehydrogenase [NAD+], cytoplasmic GPD1 0.001
91 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial NDUFA10 0.001
14 Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial IDH3A 0.001
50 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating NSDHL 0.001
112 L-lactate dehydrogenase A-like 6B LDHAL6B 0.001
216 Aldehyde dehydrogenase 3B2 ALDH3B2 0.001
616 Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial IDH3B 0.001
9 Estradiol 17-beta-dehydrogenase 2 HSD17B2 0.001
671 Pyruvate dehydrogenase E1 component alpha subunit, testis-specific form, mitochondrial PDHA2 0.001
628 Pyruvate dehydrogenase E1 component alpha subunit, somatic form, mitochondrial PDHA1 0.001
848 Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial IDH3G 0.001
145 Corticosteroid 11-beta-dehydrogenase isozyme 2 HSD11B2 0.001
539 NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial NDUFV1 0.001
609 15-hydroxyprostaglandin dehydrogenase [NAD+] HPGD 0.001
34 7-dehydrocholesterol reductase DHCR7 0.001
531 Aldehyde dehydrogenase X, mitochondrial ALDH1B1 0.001
180 D-3-phosphoglycerate dehydrogenase PHGDH 0.001
3726 D-3-phosphoglycerate dehydrogenase serA 0.001
4291 D-3-phosphoglycerate dehydrogenase serA 0.001
258 Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial ALDH6A1 0.001
644 Heme oxygenase 2 HMOX2 0.001
4982 Heme oxygenase 2 pbsA2 0.001
271 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 0.001
729 GDP-L-fucose synthetase TSTA3 0.001
3463 GDP-L-fucose synthetase fcl 0.001
487 Aldo-keto reductase family 1 member C4 AKR1C4 0.001
608 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 0.001
196 D-beta-hydroxybutyrate dehydrogenase, mitochondrial BDH1 0.001
149 Alpha-aminoadipic semialdehyde dehydrogenase ALDH7A1 0.001
335 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial NDUFA9 0.001
643 Peroxisomal bifunctional enzyme EHHADH 0.001
288 Trifunctional enzyme subunit alpha, mitochondrial HADHA 0.001
393 GDH/6PGL endoplasmic bifunctional protein [Includes: Glucose 1-dehydrogenase H6PD 0.001
496 Aldehyde dehydrogenase 3B1 ALDH3B1 0.001
662 Fatty aldehyde dehydrogenase ALDH3A2 0.001
548 NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial NDUFS1 0.001
637 NADH-ubiquinone oxidoreductase chain 5 MT-ND5 0.001
11 NAD(P) transhydrogenase, mitochondrial NNT 0.001
419 Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial HADH 0.001
77 L-lactate dehydrogenase B chain LDHB 0.001
12 Alcohol dehydrogenase class 3 ADH5 0.001
74 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial DLAT 0.001
599 Glyceraldehyde-3-phosphate dehydrogenase GAPDH 0.0009
4426 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0009
4454 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0009
4489 Glyceraldehyde-3-phosphate dehydrogenase gap 0.0009
794 Glyceraldehyde-3-phosphate dehydrogenase, testis-specific GAPDHS 0.0009
229 Retinoic acid receptor beta RARB 0.0009
1064 DNA (cytosine-5)-methyltransferase 1 DNMT1 0.0009
6105 3-oxo-5-beta-steroid 4-dehydrogenase AKR1D1 0.0009
65 Matrix metalloproteinase-9 Not Available 0.0009
730 Retinoic acid receptor alpha RARA 0.0009
1048 Protein S100-A13 S100A13 0.0009
2226 Protein S100-A12 S100A12 0.0009
6048 Troponin C, skeletal muscle TNNC2 0.0009
1759 85 kDa calcium-independent phospholipase A2 PLA2G6 0.0009
1770 Phospholipase C PLCL1 0.0009
2841 Phospholipase C plc 0.0009
830 Glutamate dehydrogenase 2, mitochondrial GLUD2 0.0009
6149 Solute carrier family 22 member 10 SLC22A10 0.0009
166 NAD-dependent malic enzyme, mitochondrial ME2 0.0009
6160 Solute carrier organic anion transporter family member 3A1 SLCO3A1 0.0009
2283 Steroid Delta-isomerase ksi 0.0009
2920 Steroid Delta-isomerase ksi 0.0009
13 Aminomethyltransferase, mitochondrial AMT 0.0009
6169 ATP-binding cassette sub-family A member 5 ABCA5 0.0009
2132 Protein S100-B S100B 0.0009
83 Alpha-aminoadipic semialdehyde synthase, mitochondrial AASS 0.0009
679 C-1-tetrahydrofolate synthase, cytoplasmic MTHFD1 0.0009
686 Aldo-keto reductase family 1 member C2 AKR1C2 0.0009
382 Glutamate receptor, ionotropic kainate 1 GRIK1 0.0008
296 Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial MTHFD2 0.0008
810 Heme oxygenase 1 HMOX1 0.0008
3391 Heme oxygenase 1 pbsA1 0.0008
6026 Alcohol dehydrogenase 6 ADH6 0.0008
22 30S ribosomal protein S4 rpsD 0.0008
6714 30S ribosomal protein S4 rpsD 0.0008
654 Flavin reductase BLVRB 0.0008
201 Glutamate dehydrogenase 1, mitochondrial GLUD1 0.0008
280 4-aminobutyrate aminotransferase, mitochondrial ABAT 0.0008
2325 Sulfotransferase family cytosolic 2B member 1 SULT2B1 0.0008
110 Pyruvate dehydrogenase E1 component subunit beta, mitochondrial PDHB 0.0008
248 Pyrroline-5-carboxylate reductase 1 PYCR1 0.0008
802 Pyrroline-5-carboxylate reductase 2 PYCR2 0.0008
626 Cysteine dioxygenase type 1 CDO1 0.0008
1867 Major prion protein PRNP 0.0008
139 Aldo-keto reductase family 1 member C1 AKR1C1 0.0008
572 Integrin alpha-L ITGAL 0.0008
2232 Interleukin-5 IL5 0.0008
1593 Mucin-2 MUC2 0.0008
4031 Glutathione S-transferase A1 GSTA1 0.0008
3868 Calcineurin subunit B isoform 2 PPP3R2 0.0008
421 Calcium signal-modulating cyclophilin ligand CAMLG 0.0008
500 Monocarboxylate transporter 4 SLC16A3 0.0008
1649 Small inducible cytokine A2 CCL2 0.0008
781 ATP-sensitive inward rectifier potassium channel 11 KCNJ11 0.0008
1025 Aquaporin-1 AQP1 0.0008
1039 Histone deacetylase 9 HDAC9 0.0008
6893 Calcium/calmodulin-dependent protein kinase type II gamma chain CAMK2G 0.0007
6155 ATP-binding cassette transporter sub-family C member 11 ABCC11 0.0007
866 Large neutral amino acids transporter small subunit 2 SLC7A8 0.0007
4226 Uridine phosphorylase 2 UPP2 0.0007
57 3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type I HSD3B1 0.0007
6263 cAMP-dependent protein kinase catalytic subunit alpha PRKACA 0.0007
130 Prostacyclin synthase PTGIS 0.0007
6103 Arylamine N-acetyltransferase 1 NAT1 0.0007
279 Tyrosinase TYR 0.0007
1768 Guanine nucleotide-binding protein G(I)/G(S)/G(O) gamma-2 subunit GNG2 0.0007
1268 Neuropeptide S receptor NPSR1 0.0007
1571 G protein-activated inward rectifier potassium channel 1 KCNJ3 0.0007
1581 G protein-activated inward rectifier potassium channel 2 KCNJ6 0.0007
6228 Nuclear receptor coactivator 1 NCOA1 0.0007
6207 30S ribosomal protein S14 rpsN 0.0007
6209 30S ribosomal protein S19 rpsS 0.0007
6712 30S ribosomal protein S19 rpsS 0.0007
6726 30S ribosomal protein S19 rpsS 0.0007
6241 Nuclear receptor coactivator 2 NCOA2 0.0007
645 Penicillin-binding protein 1A mrcA 0.0007
5805 Penicillin-binding protein 1A ponA 0.0007
6185 Penicillin-binding protein 1A mrcA 0.0007
6799 Penicillin-binding protein 1A pbpA 0.0007
3876 Aromatic-L-amino-acid decarboxylase DDC 0.0007
2298 Cytochrome P450-cam camC 0.0007
226 Gonadotropin-releasing hormone receptor GNRHR 0.0007
4225 Uridine phosphorylase 1 UPP1 0.0007
125 DNA polymerase beta POLB 0.0007
1123 Eosinophil cationic protein RNASE3 0.0007
2599 Tyrosine-protein kinase HCK HCK 0.0007
630 Short/branched chain specific acyl-CoA dehydrogenase, mitochondrial ACADSB 0.0007
6073 Potassium channel subfamily K member 9 KCNK9 0.0006
6072 Potassium channel subfamily K member 3 KCNK3 0.0006
137 FolC bifunctional protein [Includes: Folylpolyglutamate synthase folC 0.0006
413 Amidophosphoribosyltransferase PPAT 0.0006
2515 Amidophosphoribosyltransferase purF 0.0006
3714 Amidophosphoribosyltransferase purF 0.0006
6174 50S ribosomal protein L32 rpmF 0.0006
1524 Peptidyl-prolyl cis-trans isomerase A PPIA 0.0006
6700 Peptidyl-prolyl cis-trans isomerase A ppiA 0.0006
1196 Complement decay-accelerating factor CD55 0.0006
890 Niemann-Pick C1-like protein 1 NPC1L1 0.0006
3611 Cytidine deaminase cdd 0.0006
3707 Cytidine deaminase cdd 0.0006
4211 Cytidine deaminase CDA 0.0006
1291 cAMP response element-binding protein CREB1 0.0006
1525 Heparin-binding growth factor 2 FGF2 0.0006
6140 Ileal sodium/bile acid cotransporter SLC10A2 0.0006
4210 Toll-like receptor 4 TLR4 0.0005
2808 Chloramphenicol acetyltransferase 3 cat3 0.0005
1760 Aminopeptidase N ANPEP 0.0005
6843 Aminopeptidase N pepN 0.0005
3639 Thymidine phosphorylase deoA 0.0005
3936 Thymidine phosphorylase TYMP 0.0005
6151 Monocarboxylate transporter 10 SLC16A10 0.0005
2207 Rhodopsin RHO 0.0005
2417 Chloramphenicol acetyltransferase cat 0.0005
3278 Chloramphenicol acetyltransferase cat 0.0005
2810 Dr hemagglutinin structural subunit draA 0.0005
2718 Chloramphenicol 3-O phosphotransferase Not Available 0.0005
3601 Dihydropteroate synthase 1 folP1 0.0005
3807 Dihydropteroate synthase 1 folP1 0.0005
3808 Dihydropteroate synthase 2 folP2 0.0005
6002 Prostaglandin E2 receptor EP4 subtype PTGER4 0.0005
3913 Glutamic acid decarboxylase GAD65 0.0005
4131 Prostaglandin E2 receptor, EP3 subtype PTGER3 0.0004
406 Prostaglandin E2 receptor, EP2 subtype PTGER2 0.0004
4217 Telomerase reverse transcriptase TERT 0.0004
735 Alanine aminotransferase 1 GPT 0.0004
3904 Alanine aminotransferase 2 GPT2 0.0004
594 Thyroxine-binding globulin SERPINA7 0.0004
758 Thyroid hormone receptor alpha THRA 0.0003
2240 Cell division protein kinase 2 CDK2 0.0003
3961 G protein-activated inward rectifier potassium channel 4 KCNJ5 0.0003
5798 Mitogen-activated protein kinase 11 MAPK11 0.0003
199 Monocarboxylate transporter 8 SLC16A2 0.0003
2320 Thymidine kinase, cytosolic TK1 0.0003
346 Thyroid hormone receptor beta-1 THRB 0.0003
6218 Pannexin-1 PANX1 0.0003
521 ATP-binding cassette transporter sub-family C member 9 ABCC9 0.0003
132 ATP-binding cassette sub-family A member 1 ABCA1 0.0002
6135 Sodium channel subunit beta-4 SCN4B 0.0002
6134 Sodium channel subunit beta-3 SCN3B 0.0002
6132 Sodium channel subunit beta-1 SCN1B 0.0002
6127 Carbonic anhydrase-related protein CA8 0.0002
6128 Carbonic anhydrase-related protein 10 CA10 0.0002
6133 Sodium channel subunit beta-2 SCN2B 0.0002
6129 Carbonic anhydrase-related protein 11 CA11 0.0002
709 ATP-sensitive inward rectifier potassium channel 1 KCNJ1 0.0002
3803 Sodium channel protein type 3 subunit alpha SCN3A 0.0002
6130 Carbonic anhydrase 13 CA13 0.0002
489 Monocarboxylate transporter 2 SLC16A7 0.0002
4936 Cytochrome c2 iso-2 Not Available 0.0001
4916 Cyanoglobin glbN 0.0001
4994 Hemoglobin-like protein HbO glbO 0.0001
4915 Cytochrome c-550 psbV 0.0001
4959 Cytochrome c-550 psbV 0.0001
5216 Cytochrome c-550 psbV 0.0001
4925 Cytochrome c-type protein SHP shp 0.0001
4904 Cytochrome c family protein GSU1996 0.0001
4943 Cytochrome c6 petJ 0.0001
3116 Bacterioferritin bfr 0.0001
4906 Bacterioferritin bfr 0.0001
4965 Bacterioferritin bfr 0.0001
4954 Soluble cytochrome b558 Not Available 0.0001
4934 Cytochrome c-551 nirM 0.0001
5218 Cytochrome c-551 nirM 0.0001
4905 Cytochrome c2 Not Available 0.0001
4939 Cytochrome c2 cycA 0.0001
4964 Cytochrome c2 cycA 0.0001
4979 Cytochrome c2 cycA 0.0001
6673 Cytochrome c2 cycA 0.0001
4910 Cytoglobin CYGB 0.0001
4984 Neuroglobin NGB 0.0001
4981 Iron-starvation protein PigA pigA 0.0001
4909 CooA protein cooA 0.0001
4998 Hemoglobin-like protein yjbI yjbI 0.0001
4935 Cytochrome c-554 cycA1 0.0001
4947 Bacterial hemoglobin vhb 0.0001
4975 Cytochrome c-556 RPA3973 0.0001
4942 Diheme cytochrome c napB napB 0.0001
4931 Cytochrome P450 167A1 CYP167A1 0.0001
5000 HemO hemO 0.0001
4972 P450cin cinA 0.0001
4960 Putative cytochrome P450-family protein SCO7417 0.0001
4971 Nonaheme cytochrome c hmcA 0.0001
4989 Cytochrome c551 peroxidase ccp 0.0001
5222 Cytochrome c551 peroxidase ccpA 0.0001
4961 Hemophore HasA hasA 0.0001
4976 Apocytochrome f petA 0.0001
6407 Apocytochrome f petA 0.0001
4907 Cytochrome c-L moxG 0.0001
6865 Cytochrome c-L moxG 0.0001
4993 Hydroxylamine oxidoreductase hao1 0.0001
4764 Cytochrome P450 165C4 CYP165C4 0.0001
4926 Heme-based aerotactic transducer hemAT hemAT 0.0001
4952 Catalase/peroxidase katA 0.0001
4970 Cytochrome c nitrite reductase catalytic subunit nrfA 0.0001
4937 Cytochrome oxidase subunit II rcoxA 0.0001
4903 Methyl-accepting chemotaxis protein Tar4 0.0001
4999 Cytochrome P450 165B3 CYP165B3 0.0001
3093 Catalase HPII katE 0.0001
4908 Heme-regulated cyclic AMP phosphodiesterase dosP 0.0001
4922 Cytochrome c, putative SO_4144 0.0001
4920 Peroxidase/catalase katG 0.0001
4990 PpcA ppcA 0.0001
4948 Cytochrome c-553 Not Available 0.0001
4923 Cytochrome c3 DvMF_2499 0.0001
4945 Cytochrome c3 Not Available 0.0001
4949 Cytochrome c3 DVU_3171 0.0001
4968 Cytochrome c3 cytc3 0.0001
4997 Cytochrome c3 SO_2727 0.0001
5219 Cytochrome c3 cyd 0.0001
2119 Cytochrome b5 CYB5A 0.0001
4902 Nine-heme cytochrome c Ddes_2038 0.0001
3189 High-molecular-weight cytochrome c hmcA 0.0001
4956 Quinohemoprotein alcohol dehydrogenase ADH IIB qbdA 0.0001
3375 Acidic cytochrome c3 Not Available 0.0001
4988 Sulfite oxidase, mitochondrial SUOX 0.0001
2915 Sensor protein fixL fixL 0.0001
4944 Sensor protein fixL fixL 0.0001
4813 Heme oxygenase hmuO 0.0001
5769 Heme oxygenase Not Available 0.0001
3570 Cytochrome P450 152A1 cypC 0.0001
4385 Cytochrome c' Not Available 0.0001
4967 Cytochrome c' cycA 0.0001
5038 Cytochrome c' Not Available 0.0001
5223 Cytochrome c' cycP 0.0001
4037 Hypothetical protein GPX1 0.0001
4297 Hypothetical protein SP_1951 0.0001
4521 Hypothetical protein BC_2969 0.0001
4540 Hypothetical protein TM_1070 0.0001
4555 Hypothetical protein MT1739 0.0001
4569 Hypothetical protein mshD 0.0001
4578 Hypothetical protein PA3270 0.0001
4747 Hypothetical protein PA3967 0.0001
5177 Hypothetical protein TM_0096 0.0001
5194 Hypothetical protein PA1204 0.0001
5240 Hypothetical protein Rv2991 0.0001
5370 Hypothetical protein TM_1158 0.0001
5710 Hypothetical protein Tb927.5.1360 0.0001
4289 Cytochrome P450 TT_P0059 0.0001
6262 Cytochrome P450 staP 0.0001
4992 Cytochrome c peroxidase Not Available 0.0001
2230 Catalase CAT 0.0001
3249 Catalase katA 0.0001
3625 Catalase katA 0.0001
4539 Catalase katA 0.0001
4941 Catalase katB 0.0001
3670 Soluble cytochrome b562 precursor cybC 0.0001
3411 Cytochrome P450 121 cyp121 0.0001
3291 Cytochrome c-552 cycA 0.0001
4927 Cytochrome c-552 nrfA 0.0001
4938 Cytochrome c-552 cycA 0.0001
4953 Cytochrome c-552 nrfA 0.0001
5217 Cytochrome c-552 cycM 0.0001
2617 Nitric oxide synthase oxygenase nos 0.0001
2701 Nitric oxide synthase oxygenase nos 0.0001
4386 Hemoglobin-like protein HbN glbN 0.0001
3127 Nitrite reductase nirS 0.0001
3284 Nitrite reductase nirS 0.0001
2845 Bifunctional P-450:NADPH-P450 reductase CYP102A1 0.0001
2972 6-deoxyerythronolide B hydroxylase eryF 0.0001
3221 Cytochrome c4 cc4 0.0001
4608 Putative cytochrome P450 SCO1207 0.0001
4963 Putative cytochrome P450 SCO2884 0.0001
6254 Putative cytochrome P450 SCO6998 0.0001
358 Cystathionine beta-synthase CBS 0
1507 Cytochrome c CYCS 0
693 Hemoglobin subunit beta HBB 0
6268 Hydroxyacid oxidase 1 HAO1 0
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